JP4420195B2 - Heat seal structure and multi-chamber container - Google Patents

Description

  The present invention is a heat seal structure obtained by heat sealing a heat seal layer made of polyolefin resin and a heat seal layer made of polypropylene resin, and a plurality of containers each having a weak seal portion are connected by heat fusion. It is related with the multi-chamber container formed so that at least one container before connection can withstand high temperature sterilization treatment such as retort sterilization.

  For example, in the medical field, it is generally performed to store and circulate using a container in which a plurality of drug components are separated and stored, and to mix and administer immediately before administration. For example, infusion preparations for IVH include those containing carbohydrates and amino acids, which are nutrients, and electrolytes. However, liquids containing glucose and amino acids tend to be altered by the Maillard reaction, so until just before administration. Is generally stored in separate containers and mixed immediately before administration.

  Many multi-chamber containers in which such mixing can be performed in a sealed container and the inside is divided into a plurality of regions have been filed (for example, Patent Document 1: Japanese Patent No. 2675075, Patent Document 2: Patent) No. 2675049, Patent Literature 3: Japanese Utility Model Laid-Open No. 5-5138, Patent Literature 4: JP-A-8-229099, Patent Literature 5: JP-A-8-229100). These are provided with a weak seal part in a part of the container to make the inside of the container into multiple chambers, and when used, the weak seal part is broken (conducted) with hands or jigs, so that multiple contents can be kept under sealed conditions. The present invention relates to a multi-chamber container capable of mixing things.

  Here, in the multi-chamber container disclosed in Patent Document 1 and Patent Document 2, the seal layer involved in the weak seal portion is formed of a mixture of linear low-density polyethylene and polypropylene resin. The sterilization process at 121 ° C. cannot be performed with the contents of That is, when the contents contain a liquid, especially in the food and pharmaceutical fields where safety is a problem, several minutes to several tens of minutes at 121 ° C., which is a sterilization treatment according to the Food Sanitation Law or the Japanese Pharmacopoeia It is recommended to perform sterilization in the meantime. However, if the multi-chamber container as described above is placed at such a high temperature, the sealing layer may be softened to cause bag breakage or deformation of the container. Sterilization at a temperature of about ℃ must be adopted. It is difficult to perform complete sterilization at such sterilization temperatures, and thus it is necessary to place the liquid filling process under a very high level of management system, which is substantially at the same level as the aseptic filling process. Maintenance costs were enormous and contributed to the rise in product unit prices. Furthermore, when the heat seal layer is formed of a mixture of linear low density polyethylene and polypropylene resin as described above, the transparency immediately after the high temperature treatment is lowered as compared with a container using polyethylene or polypropylene alone. The problem may occur.

On the other hand, a multi-chamber container containing powdered medicine and liquid medicine is disclosed in Patent Document 6: Japanese Patent No. 3016347, Patent Document 7: Japanese Patent No. 3060132, Patent Document 8: Japanese Patent Laid-Open No. 8-280775, and the like. Has been.
As a material constituting the container on the side containing the powdered drug, a polyethylene-based resin is used as a material for forming the outermost layer from the viewpoint of safety of the powdered drug and a filling workability as a material for forming the innermost layer. From the viewpoint of imparting moisture resistance, a polyester-based resin on which silica, alumina, metal, or the like is deposited is often used. On the other hand, as a material constituting the container on the side containing the liquid medicine, a polypropylene resin is often used from the viewpoint of performing sterilization at a temperature of 121 ° C. or higher and forming a weak seal portion. That is, when configuring a multi-chamber container that contains a powder medicine and a liquid medicine, a polyolefin resin that constitutes a container that contains the powder medicine and a polypropylene resin that constitutes a container that contains the liquid medicine are bonded together. Technology is required.

However, polyethylene resin and polypropylene resin usually have various properties such as high melting point and crystallinity, so they are poorly compatible. By simply heat sealing, sufficient sealing strength can be achieved. Can not. Examples of such an adhesion method include a method using an adhesive, and a method in which a polypropylene resin layer is laminated as a container innermost layer structure on the side containing a powder drug, and the polypropylene resin is heat sealed. In the method according to the above, it is not easy to apply an adhesive at a predetermined position with a predetermined width and thickness to a predetermined position between the containers and press-bond for a predetermined time, and the layer structure of the container is simple from the viewpoint of manufacturing cost. It is desirable. In addition, when the polypropylene resin is used as the innermost layer of the container, it is not easy to completely eliminate the additive so as not to cause an interaction with the contents, and the container has flexibility and sealing properties. It is not easy to select a polypropylene resin.
A container for liquid medicine that can withstand sterilization at 121 ° C. without destroying the weak seal after housing the liquid medicine, and a container for powder medicine with an inner wall surface formed of a polyolefin resin typified by a polyethylene resin There has been a demand for a multi-chamber container obtained by joining the above and others by a heat sealing method, which is the simplest and practical method, and having a simple configuration.

Japanese Patent No. 2675075 Japanese Patent No. 2675049 Japanese Utility Model Publication No. 5-5138 JP-A-8-229099 JP-A-8-229100 Japanese Patent No. 3016347 Japanese Patent No. 3060132 JP-A-8-280775

  The present invention has been made in view of the above circumstances, and is one container that can withstand a sterilization process at 121 ° C. without deforming as a container after containing a liquid drug and retains a stable weak sealing property even after the sterilization process. And a multi-chamber container obtained by joining the other container having an inner wall surface formed of a polyolefin-based resin by heat sealing and having excellent transparency immediately after high-temperature treatment, and constituting the multi-chamber container Another object of the present invention is to provide a heat seal structure that can be suitably used for bonding a member with a polyolefin resin to a container having an inner layer surface formed of a polypropylene resin.

  As a result of intensive studies to achieve the above object, the present inventors have found that a polyolefin resin containing a linear low density polyethylene and / or a cyclic polyolefin as a main component and a polypropylene resin containing a specific component are good. The present inventors have found that the application of the technology is suitable in constructing a multi-chamber container that exhibits excellent heat-sealability and is particularly required for medical safety.

That is, the present invention provides the following heat seal structure and multi-chamber container.
Claim 1 :
A plurality of containers (I) formed by a resin film or sheet having a heat seal layer on at least one surface, and each formed with a weak seal portion provided by heat-sealing at least a part of the inner wall surface so as to be peelable; and (II) is a multi-chamber container obtained by separating and connecting each weak seal part so that they can communicate with each other, wherein the connecting part is an inner wall surface of one container (I) and the other container (II). Is formed by heat sealing with the outer wall surface of the container, and the inner wall surface of the container (I) is formed of a polyolefin resin,
The outer wall surface of the container (II) is composed of 10 to 60% by mass of the following (A) component obtained by the first stage polymerization and 90 to 40% by mass of the following (B) component obtained by the second stage polymerization. The content of the propylene unit in the total amount of the component (A) and the component (B) that contains the polymer as a main component and forms the sequential copolymer is 85 to 95% by mass, and the sequential copolymer The melting point peak temperature measured in accordance with JIS K7121 is 155 ° C. or higher, and the tensile yield stress measured in accordance with JIS K6921 of the sequential copolymer is 20 MPa or lower. ,
The inner wall surface of the container (II) contains the following component (C) and component (D) at a ratio of component (C): component (D) = 98: 2 to 50:50 (mass ratio). Formed of a polymer composition, and
The polyolefin resin forming the inner wall surface of the container (I) is a polyolefin resin containing linear low density polyethylene and / or cyclic polyolefin as a main component, or the component (C) and the component (D) ( C) component: (D) ingredient = 98: 2 to 50: 50 (multi-chamber container according to any der wherein Rukoto propylene copolymer composition in a proportion of weight ratio).
Component (A): A polymer component mainly composed of propylene having an isotactic index of 90% or more.
Component (B): It is composed of a copolymer of propylene and another α-olefin having 8 or less carbon atoms, containing propylene and ethylene as essential components, and components insoluble in xylene at room temperature are components (A) and ( B) Exceeding 20% by mass and 70% by mass or less of the total polymer combined with the component, and the component soluble in xylene at room temperature is 10% by mass in the total polymer combined with the component (A) and the component (B). A copolymer component having a content of α-olefin other than propylene in a component that is soluble in xylene at room temperature and is less than 20% by mass.
Component (C): a propylene-based copolymer component composed of propylene and ethylene and / or another α-olefin having 4 to 8 carbon atoms, and a temperature rising elution fractionation method (temperature: 0 to 140 ° C., solvent : O-dichlorobenzene), the proportion of elution at 0 ° C. is 15% by mass to 50% by mass and the proportion of elution at 60 ° C. to 90 ° C. A propylene-based copolymer component that is 5% by mass or more and less than 15% by mass with respect to the eluted amount.
Component (D): a propylene-based copolymer component composed of propylene and ethylene and / or another α-olefin having 4 to 8 carbon atoms, and a temperature rising elution fractionation method (temperature: 0 to 140 ° C., solvent : O-dichlorobenzene), the proportion of elution at 0 ° C. is 0% to 25% by mass and the proportion of elution at 60 ° C. to 90 ° C. A propylene-based copolymer component that is 15% by mass or more and 70% by mass or less with respect to the elution amount.
Claim 2 :
The polypropylene resin forming the outer wall surface of the container (II) further comprises the above component (D) (sequential copolymer comprising (A) component and (B) component): (D) component = 98: 2-50: 50 multi-chamber container according to claim 1, wherein a proportion (mass ratio).
Claim 3 :
A weak seal portion provided on the inner wall surface of the container (I) is formed of a propylene-based copolymer composition containing the component (C) and the component (D) as at least a surface layer. The multi-chamber container according to claim 1 or 2 , wherein an easy peel tape provided is inserted between the inner wall surfaces of the container (I).
Claim 4 :
The multi-chamber container according to any one of claims 1 to 3 , wherein the container (II) can be sterilized at 121 ° C.
Claim 5 :
The multi-chamber container according to any one of claims 1 to 4 , wherein the container (I) contains a powdered medicine and the container (II) contains a liquid medicine.

  The multi-chamber container of the present invention is formed by joining one housing part to which high temperature sterilization treatment such as retort sterilization can be applied and a housing part having an inner wall surface formed of a polyolefin-based resin excellent in sanitary safety by heat sealing. It is a multi-chamber container that can be obtained in a simple manner, and is excellent in transparency. In constructing the multi-chamber container, the heat seal structure of the present invention can be suitably used.

Hereinafter, the present invention will be described in more detail. FIG. 1 is a plan view showing an example of a multi-chamber container according to the present invention, and FIG. 2 is an XX cross-sectional view of the multi-chamber container shown in FIG.
The multi-chamber container 1 shown in FIGS. 1 and 2 is obtained by connecting a partial container 2 (corresponding to the container (I)) and a partial container 3 (corresponding to the container (II)). It is formed by heat sealing between the inner wall surface of the partial container 2 and the outer wall surface of the partial container 3. Moreover, the port part 4 can be suitably arrange | positioned in the partial container 3, and the injection | pouring and discharge of the content are possible through this port part. In addition, as such a port part, it is suitable to use the port part which can be closed after filling the contents or can be opened and closed.

In FIGS. 1 and 2, strong sealing portions 211 and 211 are formed on both side edges and the lower edge of the partial container 2 constituting the multi-chamber container 1 except for the center of the lower edge to be heat-sealed. The center portion of the lower edge portion is firmly heat-sealed after filling the contents to form a strong seal portion 212.
An easy peel tape 2a is interposed in the upper portion of the container 2 at a position slightly below the upper end edge. In this case, one surface of the easy peel tape 2a is firmly adhered to the upper inner wall surface of the partial container 2, and the other surface of the tape 2a is weakly sealed so as to be peelable from the upper inner wall surface of the partial container 2. 22 is formed. A resin sheet portion forming the container 2 extends above the position of the weak seal portion 22, and this portion is used as a joining allowance when the partial container 2 and the partial container 3 are joined.

On the other hand, strong seal parts 311 and 311 are formed at both side edges and the upper edge of the partial container 3 except for the center of the upper edge, and the port part 4 is inserted at the center of the upper edge. Thus, the outer peripheral surface of the port portion 4 and the central portion of the upper edge portion of the partial container 3 are firmly heat-sealed to form a strong seal portion 312. Further, a weak seal portion 32 is formed on the lower edge portion of the partial container 3 so as to be weakly peelable.
And the lower end part of the partial container 3 is inserted between two resin sheets that open and extend above the position of the weak seal portion 22 of the partial container 2, and the inner wall surface of the sheet of the partial container 2 and the partial container 3 The partial container 2 and the partial container 3 are joined by firmly heat-sealing the outer wall surface of the lower end part to form the strong seal part 213.

  Here, when the strong seal portion 213 is formed, it corresponds to the peripheral portion of the multi-chamber container 1 that is a connecting portion of both containers so that the contents do not leak from the connecting portions of the partial containers 2 and 3. The part is firmly heat sealed. In forming the strong seal portion 213, only the portion where the lower end portion of the partial container 3 and the two resin sheets extending above the partial container 2 overlap is heated, so that the seal surface of the weak seal portion 32 is strong. The weak seal portion 32 is maintained in a re-peelable state without being welded.

The partial containers 2 and 3 are each formed of a resin sheet having a three-layer structure including an outermost layer 2x or 3x, an intermediate layer 2y or 3y, and an innermost layer 2z or 3z. In the multi-chamber container 1, the separation of each chamber is ensured by the weak seal portions 22 and 32 provided in the partial containers 2 and 3, respectively. This is realized by the peeling of the innermost welding surface.
In the above, the partial containers 2 and 3 constituting the multi-chamber container 1 are formed by stacking and heat-sealing two multilayer resin sheets. In forming these partial containers, the raw material resin is formed by inflation molding. Thus, a cylindrical body of resin (either a single layer configuration or a multilayer configuration is possible) is prepared in advance, and then a partial container is formed by appropriately arranging a strong seal portion, a weak seal portion, and a port portion. A method is also suitable. The layer structure of the resin sheet constituting the partial container is not limited to three layers, and it is possible to appropriately adopt a two-layer structure or a four-layer structure or more in view of the required characteristics of the multi-chamber container.

A heat seal structure obtained by heat-sealing a heat seal layer made of a polyolefin resin and a heat seal layer made of a polypropylene resin of the present invention (hereinafter sometimes simply referred to as “heat seal structure”). Wherein the polyolefin-based resin contains linear low-density polyethylene and / or cyclic polyolefin as a main component, and the polypropylene-based resin is obtained by the first-stage polymerization and the following (A) component is 10 to 60% by mass and It is a heat seal structure characterized by including as a main component a sequential copolymer composed of 90 to 40% by mass of the following component (B) obtained by two-stage polymerization.
Component (A): A polymer component mainly composed of propylene having an isotactic index of 90% or more.
Component (B): It is composed of a copolymer of propylene and another α-olefin having 8 or less carbon atoms, containing propylene and ethylene as essential components, and components insoluble in xylene at room temperature are components (A) and ( B) Exceeding 20% by mass and 70% by mass or less of the total polymer combined with the component, and the component soluble in xylene at room temperature is 10% by mass in the total polymer combined with the component (A) and the component (B). A copolymer component having a content of α-olefin other than propylene in a component that is soluble in xylene at room temperature and is less than 20% by mass.

（式中、Ｒ¹，Ｒ²，Ｒ³，Ｒ⁴は互いに同一又は異種の炭素数１〜２０の有機基を示し、またＲ¹，Ｒ²，Ｒ³，Ｒ⁴は互いに環を形成していてもよい。ｍまたはｐは０または１以上の整数を示す。ｌおよびｎは１以上の整数を示す。）で表される構造単位を有する重合体である。
上記ポリオレフィン系樹脂には、本発明の目的を損なわない範囲で他の樹脂成分、例えば他のポリオレフィン系樹脂を配合したり、紫外線吸収剤や滑剤等の通常用いられる添加剤を配合したりすることも可能である。 The polyolefin resin constituting the heat seal structure of the present invention is mainly composed of linear low density polyethylene (hereinafter sometimes abbreviated as “LLDPE”) and / or cyclic polyolefin (the LLDPE and / or cyclic polyolefin). The proportion of the polyolefin resin in the polyolefin resin is 50% by mass or more, preferably 60% by mass or more, more preferably 70% by mass or more. It is preferable that it is LLDPE superposed | polymerized using. As such LLDPE, known ones can be used, and are not particularly limited. For example, those manufactured by Nippon Polyethylene Co., Ltd., manufactured by Nippon Polychem Co., Ltd., manufactured by Mitsui Chemicals, Inc., manufactured by Tosoh Co., Ltd., etc. It can be preferably used.
The cyclic polyolefin is a cyclic polyolefin obtained by polymerizing a monomer composition containing one or more cyclic olefin monomers selected from the group consisting of norbornenes such as dicyclopentadiene, norbornene, and tetracyclododecene. Any one or a combination thereof, and the following general formulas (1), (2),

(In the formula, R ¹ , R ² , R ³ and R ⁴ are the same or different organic groups having 1 to 20 carbon atoms, and R ¹ , R ² , R ³ and R ⁴ form a ring with each other. M or p represents 0 or an integer of 1 or more, and l and n represent an integer of 1 or more.
The polyolefin resin may be blended with other resin components such as other polyolefin resins within the range that does not impair the object of the present invention, or may be blended with commonly used additives such as ultraviolet absorbers and lubricants. Is also possible.

  In the present invention, the above-mentioned “propylene having an isotactic index of 90% or more” usually comprises a component insoluble in xylene at room temperature (crystalline component) and a component soluble in xylene at room temperature (amorphous component). However, the content of the crystalline component and the isotactic index are substantially correlated.

The component (A) is a polymer component whose main component is propylene having an isotactic index of 90% or more. The term “main component” as used herein refers to the component (A) in the polymer. It means that the proportion of “propylene having an isotactic index of 90% or more” in the total is 70% by mass or more. The proportion is preferably 90% by mass or more, more preferably 95% by mass or more, and particularly preferably 100% by mass (propylene homopolymer). If this ratio is less than 70% by mass, the container may be easily deformed or blocked due to pressure and heat sterilization at 121 ° C., resulting in poor heat resistance.
In addition, the isotactic index of polypropylene contained in the component (A) in the present invention is 90% or more, but when it is less than 90%, the container can be easily deformed at the time of heat sterilization at 121 ° C. The heat resistance is inferior, such as blocking.

  In the component (B) in the present invention, examples of other α-olefins having 8 or less carbon atoms include 1-butene, 3-methyl-1-butene, 1-pentene, and 4-methyl-1-pentene. , 1-hexene, 1-octene and the like. As the component (B) in the present invention, a propylene-ethylene copolymer is particularly preferably used.

In the component (B), the proportion of the component insoluble in xylene at room temperature in the sequential copolymer composed of the component (A) and the component (B) is more than 20% by mass and less than 70% by mass, preferably 25 to 65% by mass. %. When the proportion is 20% by mass or less, transparency of the polypropylene resin after high temperature treatment tends to be inferior, and when it exceeds 70% by mass, flexibility tends to be inferior.
In the component (B), the proportion of the component soluble in xylene at room temperature in the sequential copolymer composed of the component (A) and the component (B) is 10% by mass to 60% by mass, preferably It is 15-60 mass%. When the proportion is less than 10% by mass, the flexibility of the polypropylene-based resin tends to be inferior, and when it exceeds 60% by mass, the container is easily deformed or blocked during pressure heat sterilization at 121 ° C. The heat resistance tends to be inferior.
Furthermore, the content of α-olefin other than propylene in the “component soluble in xylene at room temperature” is less than 20% by mass, preferably 10 to 18% by mass. When the proportion is 20% by mass or more, the transparency of the polypropylene resin after high temperature treatment tends to deteriorate.

In the present invention, the polypropylene resin is composed of 10 to 60% by mass of the component (A) obtained by the first stage polymerization and 90 to 40% by mass of the component (B) obtained by the second stage polymerization. It is a polypropylene resin containing a coalescence as a main component. The “main component” as used herein means that the proportion of the sequential copolymer in the polypropylene resin is 70% by mass or more, preferably 80% by mass or more. In the polypropylene resin of the present invention, from the viewpoint of improving the weldability with the port, the later-described component (D) is a (sequential copolymer comprising (A) component and (B) component): (D) It is also suitable to mix | blend so that it may become a ratio of component = 98: 2-50: 50 (mass ratio).
The polypropylene resin may be blended with other resin components such as other polyolefin resins within the range not impairing the object of the present invention, or may be blended with commonly used additives such as ultraviolet absorbers and lubricants. Is possible.

  In the sequential copolymer contained as a main component in the polypropylene resin, the proportion of the component (A) is 10 to 60% by mass, preferably 20 to 50% by mass, while the proportion of the component (B) is 90%. It is -40 mass%, Preferably it is 50-80 mass%. When the proportion of the component (A) is less than 10% by mass and the proportion of the component (B) exceeds 90% by mass, the container is easily deformed or blocked during pressure heat sterilization at 121 ° C. When the ratio of the component (A) exceeds 60% by mass and the ratio of the component (B) is less than 40% by mass, the flexibility of the polypropylene-based resin and the transparency after the high-temperature treatment are increased. It becomes insufficient.

The sequential copolymer further satisfies the following conditions. That is,
(A) The content rate of the propylene unit which occupies for the total amount of (A) component and (B) component is 85-95 mass%.
(B) The melting point peak temperature measured according to JIS K7121 is 155 ° C. or higher.
(C) The tensile yield stress measured according to JIS K6921 is 20 MPa or less.

  Regarding the above condition (a), the propylene unit content in the sequential copolymer composed of the component (A) and the component (B) is 85 to 95% by mass, preferably 87 to 95% by mass, more preferably 88. It is -92 mass%. Therefore, the content of the α-olefin unit other than propylene having 4 to 8 carbon atoms constituting the sequential copolymer is 5 to 15% by mass, preferably 5 to 13% by mass, more preferably 8 to 12%. % By mass. If the content of the propylene unit in the sequential copolymer is too large, the flexibility of the polypropylene resin becomes poor, and if the content of the propylene unit in the sequential copolymer is too small, the transparency of the polypropylene resin decreases. It becomes a trend.

  The above condition (b) means that the polypropylene resin in the present invention has a melting point equivalent to that of a homopolymer of propylene and is excellent in heat resistance, and the above condition (c) Means that the polypropylene resin in the present invention is rich in flexibility.

  In the polypropylene resin, the component (A) is obtained by the first stage polymerization, and the component (B) is obtained by the second stage polymerization. That is, for example, after a propylene homopolymer is produced in the first stage, propylene and ethylene having 4 to 8 carbon atoms are essential components of propylene and ethylene in the presence of the polymer obtained in the previous stage in the second stage polymerization. The α-olefin is fed to produce a sequential copolymer.

  The catalyst used for such sequential polymerization is not particularly limited, but a catalyst composed of an organoaluminum compound and a solid component essentially comprising a titanium atom, a magnesium atom, a halogen atom, and an electron donating compound. preferable.

Here, as said organoaluminum compound, for example, general formula R ⁵ _m AlX _(3-m) (wherein R ⁵ is a hydrocarbon residue having 1 to 12 carbon atoms, X represents a halogen atom, m Is a number from 1 to 3). Specific examples of such organoaluminum compounds include trialkylaluminum halides such as trimethylaluminum chloride and triethylaluminum chloride, dialkylaluminum halides such as dimethylaluminum chloride and diethylaluminum chloride, alkyls such as methylaluminum sesquichloride and ethylaluminum sesquichloride. Examples include aluminum sesquihalides, alkylaluminum dihalides such as methylaluminum dichloride and ethylaluminum dichloride, and alkylaluminum hydrides such as diethylaluminum hydride.

In addition, as a solid component essentially including the titanium atom, magnesium atom, halogen atom, and electron donating compound, known components can be used in this kind of polymerization, and as a titanium compound serving as a titanium atom supply source, For example, the general formula Ti (OR ⁶ ) _(4-n) X _n (wherein R ⁶ is a hydrocarbon residue having 1 to 10 carbon atoms, X is a halogen atom, and n is a number from 0 to 4) A compound represented by the formula (1) is used. Of these, titanium tetrachloride, tetraethoxy titanium, tetrabutoxy titanium and the like are preferably used.

  Examples of the magnesium compound that serves as a supply source of the magnesium atom include dialkyl magnesium, magnesium dihalide, dialkoxy magnesium, and alkoxy magnesium halide. Among these, magnesium dihalide is preferable. Examples of the halogen atom include fluorine, chlorine, bromine and iodine. Among them, chlorine is preferable. The halogen atom is usually supplied from the above-described titanium compound or magnesium compound, but may be supplied from another halogen source such as an aluminum halide, a silicon halide, or a tungsten halide.

  Further, examples of the electron donating compound include alcohols, phenols, ketones, aldehydes, carboxylic acids, oxygen-containing compounds such as organic acids or inorganic acids and derivatives thereof, ammonia, amines, nitriles, and isocyanates. Among them, inorganic acid esters, organic acid esters, and organic acid halides are preferable, and silicic acid esters, phthalic acid esters, acetic acid cellosolve esters, and phthalic acid halides are particularly preferable.

Here, as said silicate ester, for example, the general formula R ⁷ R ⁸ _(3-p) Si (OR ⁹ ) _p (wherein R ⁷ is a branch having 3 to 20 carbon atoms (preferably 4 to 10). Represents an aliphatic hydrocarbon residue or a cyclic aliphatic hydrocarbon residue having 5 to 20 carbon atoms (preferably 6 to 10 carbon atoms), and R ⁸ represents a branch having 1 to 20 carbon atoms (preferably 1 to 10 carbon atoms) or A linear aliphatic hydrocarbon residue, R ⁹ represents an aliphatic hydrocarbon residue having 1 to 10 carbon atoms (preferably 1 to 4 carbon atoms, and p is a number of 1 to 3). Organic silicon compounds. Specific examples of such organosilicon compounds include t-butyl-methyl-dimethoxysilane, t-butyl-methyl-diethoxysilane, cyclohexyl-methyl-dimethoxysilane, and cyclohexyl-methyl-diethoxysilane.

  In producing the polypropylene-based resin in the present invention, propylene or propylene and a small amount of ethylene and / or other α-olefin having 4 to 8 carbon atoms are supplied during the first stage polymerization, and the presence of the catalyst as described above. The polymerization is carried out under the conditions of a polymerization temperature of 50 to 150 ° C., preferably 50 to 100 ° C., and a partial pressure of propylene of 0.5 to 4.5 MPa, preferably 1.0 to 3.5 MPa. In the polymerization, propylene and ethylene and / or α-olefin having 4 to 8 carbon atoms are supplied in the presence of the polymer obtained in the first stage polymerization, and the temperature is 50 to 150 ° C. in the presence of the catalyst, preferably Conditions of 50 to 100 ° C., partial pressure of propylene and ethylene and / or other α-olefin having 4 to 8 carbon atoms, each 0.3 to 4.5 MPa, preferably 0.5 to 3.5 MPa , It is possible to perform the copolymerization.

  In this case, the polymerization method may be any of batch, continuous, and semi-batch, but the first and second polymerizations are preferably carried out in the gas phase or liquid phase. The residence time of the stages can usually be 0.5 to 10 hours, preferably 1 to 5 hours, respectively. In addition, when there is a problem such as stickiness in the powder particles of the composition produced by such a method, the second-stage polymerization is performed after the first-stage polymerization for the purpose of imparting fluidity to the powder particles. Active hydrogen in the range of 100 to 1000 times mol of titanium atoms in the solid component of the catalyst and 2 to 5 times mol of the organoaluminum compound of the catalyst before the start of the polymerization or during the second stage polymerization It is preferable to add a containing compound. Examples of such active hydrogen-containing compounds include water, alcohols, phenols, aldehydes, carboxylic acids, acid amides, ammonia, amines and the like.

  The heat seal structure of the present invention includes a heat seal layer made of a polypropylene resin as described above and a heat seal layer made of a polyolefin resin mainly containing a linear low density polyethylene and / or a cyclic polyolefin. It is the heat seal structure obtained by doing. When performing heat sealing, a heat sealing layer such as an impulse sealing method, a high frequency sealing method, etc. in addition to a normal heat sealing method in which a target sealing portion is sandwiched between a pair of heating elements adjusted to a predetermined temperature and pressed. It is possible to employ a known method for sealing by inducing heat generation.

The multi-chamber container of the present invention is formed of a resin film or sheet having a heat seal layer on at least one side, and forms a weak seal portion provided by heat-sealing at least a part of the inner wall surface so as to be peelable. A plurality of containers (I) and (II) are obtained by connecting each of the weak seal portions so that they can be separated and communicated with each other, wherein the connection portion is an inner wall surface of one of the containers (I) And the outer wall surface of the other container (II), the inner wall surface of the container (I) is formed of a polyolefin-based resin, and the outer wall surface of the container (II) is A multi-chamber container formed of a polypropylene-based resin.
When forming a multi-chamber container that contains a powder medicine in one container and a liquid medicine in the other container, the material of the inner wall surface of the container that comes into contact with the powder medicine is a polyolefin resin, preferably polyethylene from the viewpoint of safety. Polyolefin resin containing as a main component a resin and / or a cyclic polyolefin resin is used. On the other hand, the material of the container inner wall surface in contact with the container inner wall surface in contact with the liquid drug is heat resistant from the viewpoint of applying high temperature sterilization treatment. Some materials, more specifically, polypropylene resins are preferably used.
In the present invention, when the containers (I) and (II) are configured, the inner wall surface of the container (I) is formed of a polyolefin resin, and the outer wall surface of the container (II) is formed of the specific polypropylene resin described above. By doing so, it is possible to ensure sufficient heat-sealability even with different materials. Therefore, when the weak seal portion formed in each container (I) and (II) is communicated, the polyolefin It is possible to provide a multi-chamber container in which the heat-welded surface between the polypropylene resin and the polypropylene resin is not destroyed, and the possibility that the contents are scattered outside the container is reduced as much as possible. Become.

As a material for the inner wall surface of the container (II), a propylene copolymer composition containing the following component (C) and component (D) from the viewpoint of forming a stable weak seal after sterilization at 121 ° C: Is preferably used.
Component (C): a propylene-based copolymer component composed of propylene and ethylene and / or another α-olefin having 4 to 8 carbon atoms, and a temperature rising elution fractionation method (temperature: 0 to 140 ° C., solvent : O-dichlorobenzene), the proportion of elution at 0 ° C. is 15% by mass to 50% by mass and the proportion of elution at 60 ° C. to 90 ° C. A propylene-based copolymer component that is 5% by mass or more and less than 15% by mass with respect to the eluted amount.
Component (D): a propylene-based copolymer component composed of propylene and ethylene and / or another α-olefin having 4 to 8 carbon atoms, and a temperature rising elution fractionation method (temperature: 0 to 140 ° C., solvent : O-dichlorobenzene), the proportion of elution at 0 ° C. is 0% to 25% by mass and the proportion of elution at 60 ° C. to 90 ° C. A propylene-based copolymer component that is 15% by mass or more and 70% by mass or less with respect to the elution amount.

  Here, temperature rising elution fractionation (TREF) is a known method for analyzing the composition distribution of a polymer, and in principle, since each polymer component has a different crystal structure, In this method, the composition distribution of the polymer is analyzed by utilizing the fact that the deposition rate or dissolution rate of the polymer is different for each polymer. That is, when a polymer is completely dissolved in a solvent at a high temperature and then gradually cooled in the presence of an inert carrier, first, a highly crystalline polymer component that is easily crystallized first precipitates on the surface of the inert carrier. A polymer layer is formed, and then a low crystalline or amorphous polymer component that is difficult to crystallize is deposited to form a polymer layer. Next, after the polymer layer is formed in this way, when the temperature is raised continuously or stepwise, the low crystalline or amorphous polymer component is eluted, and the high crystalline polymer component is finally eluted. Become. That is, it is possible to analyze the polymer composition distribution from the elution curve drawn by the elution amount and elution temperature at each temperature. In the present invention, o-dichlorobenzene is used as a solvent used in the temperature rising elution fractionation method, and a temperature range of 0 to 140 ° C. is employed.

  In the present invention, the proportion of the component (C) eluted at 0 ° C. accounts for 15% by mass or more, preferably 18% by mass or more, and the upper limit is 50% by mass or less, preferably 40% by mass. % Or less. If the ratio is too small, since the region where the change in the seal strength with respect to the change in the heat seal temperature of the propylene-based copolymer composition is hardly exhibited, the seal strength of the weak seal portion cannot be easily controlled. The effects of the present invention are not achieved, the flexibility is inferior, the touch of the created multi-chamber container is increased, and the drop strength tends to be inferior. On the other hand, if the ratio is too large, the inner wall surface blocks when the sterilization treatment at 121 ° C. is performed, and the contents cannot be filled.

  The proportion of the component (C) eluted at 60 ° C. or more and 90 ° C. or less is 5% by mass or more, preferably 6% by mass or more, and the upper limit is 15% by mass or less. It is 10 mass% or less. If the ratio is too small, the propylene-based copolymer composition is inferior in transparency after high-temperature treatment, while if the ratio is too large, the propylene-based copolymer composition is inferior in heat resistance and the resulting composite is obtained. The chamber container is deformed after sterilization at 121 ° C. )

  In the present invention, the proportion of the elution amount of the component (D) at 0 ° C. with respect to the total elution amount is 0% by mass or more, preferably 2% by mass or more, and the upper limit is 25% by mass or less, preferably 15% by mass. % Or less. When the ratio is too large, the inner surface of the container blocks when it is sterilized at 121 ° C., making it difficult to discharge the contents.

  The proportion of the component (D) eluted at 60 ° C. or more and 90 ° C. or less is 15% by mass or more, preferably 20% by mass or more, and the upper limit is 70% by mass or less, preferably 70% by mass or less. 60% by mass or less. If the ratio is too small, it is difficult to stably heat-seal the weakly sealed portion. On the other hand, if the ratio is too large, the heat resistance of the propylene-based copolymer composition is inferior, and the prepared container is 121. It tends to be deformed after sterilization at 0 ° C., and it becomes difficult to stably heat-seal the weakly sealed portion.

  The inner wall surface of the container (II) in the present invention is preferably formed of a propylene copolymer composition containing the component (C) and the component (D). Component C: Component (D) = 98: 2 to 50:50 (mass ratio), preferably 95: 5 to 60:40 (mass ratio). When the component (C) exceeds the range and the component (D) is less than the range, it tends to be difficult to stably heat-seal the weak seal portion. On the other hand, even when the component (C) is less than the above range and the component (C) exceeds the above range, it is difficult to stably heat-seal the weakly sealed portion, and the sealing performance with the port portion at the time of container preparation is poor. It becomes a trend.

  As the polyolefin resin forming the inner wall surface of the container (I), a polyolefin resin containing, as a main component, a linear low density polyethylene and / or a cyclic polyolefin resin having relatively little interaction with the contents, or From the viewpoint of forming a weak seal without insertion of an easy peel tape, a sequential copolymer composed of the component (A) and the component (B), or the component (C) as in the case of the inner wall surface of the container (II) And the above component (D) are preferably a propylene copolymer composition containing (C) component: (D) component = 98: 2 to 50:50 (mass ratio).

The propylene copolymer component of the component (C) and the component (D) is a propylene copolymer component composed of propylene and / or ethylene and / or another α-olefin having 4 to 8 carbon atoms.
Here, examples of the α-olefin having 4 to 8 carbon atoms include butene-1, 3-methylbutene-1, pentene-1, 4-methylpentene-1, hexene-1, octene-1, and the like. These can be used alone or in combination of two or more.
More specifically, the propylene copolymer component in the present invention is more specifically a copolymer component composed of propylene and ethylene, or a propylene copolymer composed of propylene, ethylene and another α-olefin having 4 to 8 carbon atoms. It is preferably a polymer component, and it is preferable to employ butene-1 as the other α-olefin having 4 to 8 carbon atoms.

  The propylene copolymer component of the component (C) and the component (D) in the present invention is the above-mentioned conditions, that is, in the temperature rising elution fractionation between 0-140 ° C. using o-dichlorobenzene as a solvent. The propylene copolymer component satisfying the ratio of the elution at 0 ° C. and the elution at 60 ° C. or more and 90 ° C. or less within the above ranges is not particularly limited. Various methods can be adopted as the method.

Examples of the method for producing the propylene copolymer component (C) and the component (D) include the following methods (i) to (iii):
(I) When carrying out sequential polymerization of at least two stages, at the time of the first stage polymerization, a propylene homopolymer, or a small amount of propylene and a small amount of ethylene and / or other α-olefins having 4 to 8 carbon atoms are introduced and randomly copolymerized. After the production of the polymer, a random copolymer of propylene and ethylene and / or another α-olefin having 4 to 8 carbon atoms in the presence of the polymer obtained in the previous stage in the second and subsequent polymerizations. Manufacturing method,
(Ii) a propylene homopolymer, or a random copolymer of propylene and a small amount of ethylene and / or another α-olefin having 4 to 8 carbon atoms, and ethylene and another α-olefin having 4 to 8 carbon atoms A random copolymer of
(Iii) Propylene homopolymer, or a random copolymer of propylene and a small amount of ethylene and / or other α-olefin having 4 to 8 carbon atoms, and random of ethylene and / or 4 to 8 carbon atoms and propylene A method of blending with a copolymer,
Can be adopted. Among these, it is preferable to use the method (i) from the viewpoint of economy.

  Here, with respect to the catalyst, polymerization method, polymerization method and the like used in the sequential polymerization of (i) above, the same conditions as those for producing the above (A) component and (B) component can be employed.

  In the present invention, the propylene-based copolymer component as the component (C) and the component (D) is eluted at 0 ° C. in the temperature rising elution fractionation between 0-140 ° C. using o-dichlorobenzene as a solvent. And the proportion of elution at 60 ° C. or higher and 90 ° C. or lower are adjusted so as to be in a specific range, respectively. Examples include a method for controlling the crystallinity of a propylene-based copolymer by multistage copolymerization of ethylene and / or an α-olefin having 4 to 8 carbon atoms, and a method for controlling the stereoregularity of propylene polymerization of a catalyst. .

In the propylene copolymer component of the component (C) and the component (D) in the present invention, a styrene elastomer having a styrene content of 25% by mass or less is used from the viewpoint of widening the heat seal temperature range for obtaining weak seal strength. It is suitable to mix. The blending amount is usually 1% by mass or more, preferably 5% by mass or more, and usually 10% by mass or less, preferably 8% by mass or less as an upper limit as a proportion of the propylene-based copolymer composition. When the proportion of the styrene-based elastomer in the propylene-based copolymer component is less than 1% by mass, the heat seal temperature range for obtaining weak seal strength may be narrowed, whereas when it exceeds 10% by mass, Procking may occur.
In the present invention, the proportion of the total amount of the component (C) and the component (D) in the propylene-based copolymer composition is usually 70% by mass or more, preferably 90% by mass or more, more preferably It is 95 mass% or more. If the ratio is too small, there may be no sufficient effect of expanding the heat seal temperature range for obtaining weak seal strength.

  The propylene copolymer composition of the present invention further includes various conventionally known antioxidants, light stabilizers, neutralizers, α crystal nucleating agents, β crystal nucleating agents, antiblocking agents, lubricants, and the like. You may mix | blend an additive suitably in the range which does not impair the objective of this invention.

  In the present invention, the container (I) and the container (II) are joined by heat-sealing the inner wall surface of the container (I) and the outer wall surface of the container (II), and the container (II) is sandwiched between the containers (I). Will be heat sealed. Therefore, since the heat sealing conditions when joining both containers tend to be severer conditions than the normal heat sealing conditions, a part of the container (II) is particularly thinned by thermal welding after joining, There is a risk of the contents leaking. In such a case, it is particularly preferable to reinforce by inserting an intermediate layer between the layer forming the inner wall surface and the layer forming the outer wall surface as a configuration of the container (II). By inserting, it is possible to reduce the risk of the content leakage due to the container sag by heat sealing or the thin film or sheet.

  As a material for forming such an intermediate layer, one or more selected from the group consisting of cyclic polyolefin, the above-mentioned components (A), (B), (C) and (D) and a metallocene plastomer A composition or a composition of one or more selected from the group consisting of the above components (A), (B), (C) and (D) and a thermoplastic elastomer is preferably used. In particular, when a composition of one or more selected from the group consisting of the components (A), (B), (C) and (D) and a metallocene plastomer is used as the intermediate layer material In addition, since the flexibility of the multi-chamber container of the present invention is improved and the compatibility between the intermediate layer and the layer in contact with the intermediate layer is improved, the transparency of the container is reduced even when sterilization is performed at 121 ° C. It is preferable because a container that does not occur can be obtained.

The metallocene plastomer has a melt flow rate at 190 ° C. of 0.5 to 10 g / 10 min and a density of 0.87 to 0.9 g / cm ³ from the viewpoint of high temperature processing resistance. A metallocene plastomer is preferred.
The thermoplastic elastomer is preferably a styrene elastomer having a styrene content of 25% by mass or less from the viewpoint of transparency after high temperature treatment.

  When the resin film or sheet in the present invention has a structure of three or more layers as described above, the laminating method is not particularly limited, but any of dry laminating method, extrusion laminating method, and multilayer coextrusion method Alternatively, a method of forming by a combination thereof is preferably used.

In the present invention, the weak seal portion means a seal portion that is detachable from the heat seal, and the seal strength is not particularly limited, but in JIS-Z0238 of the weak seal portion in the multi-chamber container of the present invention. The heat seal strength (180 ° peel strength) measured in conformity with the heat seal strength is preferably 1 to 6 N / 15 mm.
In addition, the heat seal condition for realizing the heat seal strength of such a weak seal portion is appropriately set in view of the material configuration, layer thickness, etc. of the resin film or sheet provided with the heat seal layer on at least one side. However, for example, as shown in the examples described later, the sealing temperature can be set to 145 to 180 ° C. with a sealing pressure of 0.2 MPa and a sealing time of 2 seconds. That is, it is possible to ensure a wide heat sealing temperature range of 30 ° C. or higher where a weak seal portion can be formed. Since the heat seal strength gradually increases as the heat seal temperature rises, the heat seal strength of the weak seal portion can be easily and freely controlled.
It should be noted that a condition of 0.1 to 0.6 MPa can be employed as the seal pressure when forming the weak seal portion, and a condition of 1 to 8 seconds can be employed as the seal time.

  As described above, when the heat seal layer forming the inner wall surface of the multi-chamber container of the present invention is formed of a propylene-based copolymer composition containing the component (C) and the component (D), it is weak. When the seal portion is formed, the seal strength can be easily and freely controlled. As a result, the heat seal strength can be set according to the volume or mass of the contents to be contained. That is, for example, when the total internal volume is less than 500 ml, the weak seal strength of the container is 1 to 3 N / 15 mm, and when the total internal volume is 500 ml or more, the weak seal strength of the container is 3 to 3 N / 15 mm. It is possible to easily set 6 N / 15 mm, and it is possible to control the optimum weak seal strength range depending on the inner volume of the container. If the seal strength of the weak seal part exceeds 3 N / 15 mm for a container with a total internal volume of less than 500 ml, not only is the work of peeling the weak seal part by pressing difficult, but other than the weak seal part of the multi-chamber container Part breakage may occur. Further, if the seal strength of the weak seal portion is less than 3 N / 15 mm for a container having a total content of 500 ml or more, the weak seal portion may be communicated during transportation or dropping.

In the multi-chamber container of the present invention, from the viewpoint of being applicable to a wide range of containers from a small capacity to a large capacity, the seal strength of the weak seal portion is 1 to 6 N / 15 mm, and the heat seal portion other than the weak seal portion, that is, It is preferable that the heat seal strength of the strong seal portion provided at the peripheral portion of the multi-chamber container is 20 N / 15 mm or more.
The heat seal condition for realizing such a strong seal portion is appropriately set in view of the material configuration, layer thickness, etc. of the resin film or sheet to be used. For example, the condition is 200 ° C. (pressure 0.2 MPa, time 2 seconds) Can be adopted. As a heat seal condition for forming a strong seal part, it is often unnecessary to set a strict seal condition compared to the case of forming the weak seal part, and it is usually 200 ° C. or higher, preferably 210 ° C. or higher. If the temperature is set, it is possible to form a strong seal part under normally used pressure conditions and time conditions, but the seal pressure when forming the strong seal part is 0.1 to 0.6 MPa, and the seal time is 0. The condition of 5 to 8 seconds can be adopted.

In forming the multi-chamber container of the present invention, when the container (I) and the container (II) are joined by heat sealing, or when the outer peripheral surface of each container is formed by heat sealing, the present invention The same sealing method as in the case of forming the above heat seal structure can be adopted.
Moreover, when providing a weak seal part, the tape for easy peel which equips each container with the heat seal layer which consists of a propylene-type copolymer composition containing the said (C) component and (D) component as a surface layer at least. A method of providing the portion by heat-sealing in a state where the portion is inserted between the opposing inner wall surfaces of the container (I) and the container (II) can also be suitably employed. By providing the weak seal portion in this way, the weak seal portion and the strong seal portion are placed under the same heat seal condition without providing a difference in the heat seal conditions between the weak seal portion and the other seal portions. The manufacturing process can be simplified.

  The container (II) constituting the multi-chamber container of the present invention has a total light transmittance of 80% or more, a haze of 25% or less, and a tensile modulus of 400 MPa or less immediately after sterilization at 121 ° C. for 30 minutes. It is preferable that In the present invention, “total light transmittance” and “haze” mean total light transmittance and haze measured in accordance with JIS-K7105, and “tensile modulus” in accordance with JIS-K7127. It means the measured tensile modulus.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example.

[Example 1]
Container (I-1)
After producing the sheet | seat by the structure shown in the following table 1, the single-sided transparent container (I-1) was obtained by heat-sealing innermost layers using a front sheet | seat on one side and a rear sheet | seat on one side. Each layer constituting the sheet is bonded by a dry laminating method using an ethyl acetate solution of an isocyanate curable urethane adhesive (“Takelac A520” manufactured by Mitsui Takeda Chemical Co., Ltd., adhesive layer thickness: 2 μm) as an adhesive. Combined. The weak seal part was prepared by mixing polyethylene and polypropylene in a ratio of 3: 7 (mass ratio), melt-extrusion using an extruder provided with a T die, and then producing a tape having a thickness of 100 μm. The tape was inserted into 1) and sealed from outside the container at 170 ° C. and a pressure of 0.4 MPa for 3 seconds. The heat seal strength of the weak seal part was 2 N / 15 mm. Here, “heat seal strength” means the heat seal strength (180 ° peel strength) measured in accordance with JIS-Z0238. The same applies hereinafter.
Container (II-1)
After producing a sheet having a three-layer structure shown in Table 1 below by multilayer coextrusion using an extruder provided with a T die, the innermost layers of the two sheets are heat-sealed to form a double-sided transparent container ( II-1) was obtained. The weak seal portion was provided by overlapping the innermost layers of the container and heat-sealing them from the outside of the container at 160 ° C. and a pressure of 0.2 MPa for 2 seconds. The heat seal strength of this weakly sealed portion was 3 N / 15 mm. In addition, the temperature range which can form this weak seal part was 145-180 degreeC as shown in the following table 2. It was found that a width of 35 ° C. was secured as the width of the temperature range in which the weak seal portion can be formed.

[Container (I-1)]
PET
“Ester E5102” manufactured by Toyobo Co., Ltd.
Alumina-deposited PET
Toppan Printing Co., Ltd. GL film.
LLDPE
“Harmolex” manufactured by Nippon Polyethylene Corporation.
Aluminum foil Aluminum foil made by Sun Aluminum Co., Ltd.
[Container (II-1)]
(A) + (B)
Successive copolymer obtained by multistage polymerization manufactured by Mitsubishi Chemical Co., Ltd. Polymerization type polypropylene TPO
(C)
Successive copolymer obtained by multistage polymerization manufactured by Mitsubishi Chemical Co., Ltd. Polymerization type polypropylene TPO
(C) + (D)
Sequential copolymer obtained by multistage polymerization manufactured by Mitsubishi Chemical Co., Ltd. Dry blend of polymerized polypropylene TPO and propylene copolymer manufactured by Mitsubishi Chemical Co., Ltd.

＊）ＪＩＳ−Ｚ０２３８に準拠して測定したヒートシール強度（１８０°剥離強度）。シール条件：圧力０．２ＭＰａ、シール時間２秒間。本発明においては、シール強度が６Ｎ／１５ｍｍ以下である場合、弱シール部と認定した。

*) Heat seal strength (180 ° peel strength) measured according to JIS-Z0238. Sealing conditions: pressure 0.2 MPa, sealing time 2 seconds. In the present invention, when the seal strength is 6 N / 15 mm or less, it is recognized as a weak seal portion.

The container (II-1) is provided with a port part by heat sealing, and after filling the port part with 100 ml of distilled water and sealing the port part, the container is sterilized with a sterilizer at 121 ° C. for 40 minutes. The weak seal part was not broken, and no deformation of the container was observed. The total light transmittance of the container (II-1) immediately after the high temperature sterilization treatment was 90%.
Then, when the outer wall surface of the container (II-1) and the inner wall surface of the container (I-1) were overlapped and heat sealed at 210 ° C., 0.4 MPa for 2 seconds, both containers had sufficient sealing strength. (25N / 15mm) was joined, and a one-bag type multi-chamber container could be obtained. At this time, there was no leakage of distilled water contained in the container (II-1), and no deformation of the container was observed.

[Example 2]
A one-bag type multi-chamber container was obtained in the same manner as in Example 1 except that the container (II-2) having the configuration described in Table 3 below was used instead of the container (II-1). The total light transmittance of the container (II-2) immediately after the high temperature sterilization treatment was 90%.
When heat sealing the outer wall surface of the container (II-2) and the inner wall surface of the container (I-1), conditions of 210 ° C., 0.4 MPa, and 2 seconds were employed. Both containers were joined with a sufficient seal strength (25 N / 15 mm). At this time, there was no leakage of distilled water for injection contained in the container (II-2), and no deformation of the container was observed.

（Ａ）＋（Ｂ）、及び（Ｃ）＋（Ｄ）
実施例１と同様である。
（Ｃ）＋メタロセンプラストマー
三菱化学（株）製の逐次共重合体（Ｃ）と日本ポリケム（株）製カーネルをドライブレンド

(A) + (B) and (C) + (D)
The same as in the first embodiment.
(C) + metallocene plastomer Dry blend of sequential copolymer (C) manufactured by Mitsubishi Chemical Co., Ltd. and kernel manufactured by Nippon Polychem Co., Ltd.

[ Reference Example 3]
A one-bag type multi-chamber container was obtained in the same manner as in Example 1 except that the container (II-3) having the configuration described in Table 4 below was used instead of the container (II-1). The total light transmittance of the container (II-3) immediately after the high temperature sterilization treatment was 92%.
When heat sealing the outer wall surface of the container (II-3) and the inner wall surface of the container (I-1), conditions of 210 ° C., 0.4 MPa, and 2 seconds were employed. Both containers were joined with sufficient sealing strength (25 N / 15 mm). At this time, there was no leakage of distilled water contained in the container (II-3), and no deformation of the container was observed.

（Ａ）＋（Ｂ）＋（Ｄ）
三菱化学製のＡとＢとからなる多段重合により得られる逐次共重合体とポリプロヒレン系共重合体とのドライブレンド
（Ｃ）＋熱可塑性エラストマー
三菱化学製の逐次共重合体Ｃとクラレ製ハイブラーとのドライブレンド
（Ｃ）＋（Ｄ）
実施例１と同様である。

(A) + (B) + (D)
Dry blend of sequential copolymer obtained by multi-stage polymerization of A and B made by Mitsubishi Chemical and polypropylene copolymer
(C) + thermoplastic elastomer Dry blend of sequential copolymer C made by Mitsubishi Chemical and Kuraray Hibler
(C) + (D)
The same as in the first embodiment.

Example 4
A single bag-type multi-chamber container was obtained in the same manner as in Example 1 except that the container (II-4) having the configuration shown in Table 5 below was used instead of the container (II-1). The total light transmittance of the container (II-4) immediately after the high temperature sterilization treatment was 93%.
When heat sealing the outer wall surface of the container (II-4) and the inner wall surface of the container (I-1), conditions of 210 ° C., 0.4 MPa, 3 seconds were employed. Both containers were joined with sufficient sealing strength (25 N / 15 mm). At this time, there was no leakage of distilled water contained in the container (II-4), and no deformation of the container was observed.

（Ａ）＋（Ｂ），及び（Ｃ）＋（Ｄ）
実施例１と同様である。
接着性樹脂
三菱化学（株）製モディック。
環状ポリオレフィン
日本ゼオン（株）製ゼオネックス。

(A) + (B), and (C) + (D)
The same as in the first embodiment.
Adhesive resin Modic manufactured by Mitsubishi Chemical Corporation.
Cyclic polyolefin Nippon Zeon Co., Ltd. ZEONEX.

Example 5
The innermost layer of the front sheet and rear sheet of the container (I-1) is a container (I-5) composed of (C) + (D) polypropylene resin (same as in Example 1), and a weak seal portion At the time of formation, the innermost layers of the container were overlapped and heat sealed from outside the container at 150 ° C. and a pressure of 0.4 MPa for 2 seconds, except that a weak seal portion having a seal strength of 2.5 N / 15 mm was formed. A single bag type multi-chamber container was obtained in the same manner as in Example 1.
When heat sealing the outer wall surface of the container (II-1) and the inner wall surface of the container (I-5), conditions of 210 ° C., 0.4 MPa, 3 seconds were employed. Both containers were joined with sufficient sealing strength (25 N / 15 mm). At this time, there was no leakage of distilled water contained in the container (II-1), and no deformation of the container was observed.

Example 6
The weak seal portion in the container (I-1) is first melt-extruded by using (C) + (D) polypropylene resin (same as in Example 1) using an extruder provided with a T die. A tape having a thickness of 100 μm was prepared, and then the tape was inserted into the container (I-1) and heat sealed at 180 ° C., a pressure of 0.4 MPa for 3 seconds from the outside of the container, and the same as in Example 1. Thus, a one-bag type multi-chamber container was obtained. The heat seal strength of the weak seal portion was 2.5 N / 15 mm.
As in Example 1, when heat sealing was performed at 210 ° C., 0.4 MPa for 3 seconds, both containers were joined with sufficient sealing strength (25 N / 15 mm) to obtain a one-bag type multi-chamber container. did it. At this time, there was no leakage of distilled water for injection contained in the container (II-1), and no deformation of the container was observed.

Example 7
The innermost layer of the front sheet and rear sheet of the container (I-1) is a container (I-7) composed of a cyclic polyolefin (ZEONOR 1020R manufactured by Nippon Zeon Co., Ltd.). ZEONOR 1020R) and linear low-density polyethylene (Idemitsu Petrochemical Motec) were blended at a ratio of 6: 4, and then melt-extruded using an extruder equipped with a T-die to produce a 100 μm thick tape. Then, in the same manner as in Example 1 except that the tape was inserted into the container (I-7) and heat sealed at 180 ° C., pressure 0.4 MPa, and 3 seconds from the outside of the container. A multi-chamber container was obtained. When heat sealing the outer wall surface of the container (II-1) and the inner wall surface of the container (I-7), conditions of 210 ° C., 0.4 MPa, 3 seconds were employed. Both containers were joined with sufficient sealing strength (25 N / 15 mm). At this time, there was no leakage of distilled water contained in the container (II-1), and no deformation of the container was observed.

[Comparative Example 1]
The outermost layer of the container (II-1) is made of random polypropylene (VSR manufactured by Chisso Corporation) and homopolypropylene (F300SP manufactured by Idemitsu Petrochemical Co., Ltd.), (random polypropylene): (homopolypropylene) = 9: 1 An attempt was made to obtain a single-bag type multi-chamber container in the same manner as in Example 1 except that it was formed using a polypropylene-based resin contained at a ratio of (mass ratio). (I) Container and (II) container Could not be joined together by welding, and a one-bag type multi-chamber container could not be obtained.

It is a top view which shows an example of the multiple chamber container of this invention. It is XX sectional drawing of the multi-chamber container shown in FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Multi-chamber container 2,3 Partial container 211,212,213 Strong seal part 22 Weak seal part 2a Easy peel tape 2x Outermost layer 2y Intermediate layer 2z Inner layer 311, 312 Strong seal part 32 Weak seal part 3x Outermost layer 3y Intermediate Layer 3z Innermost layer 4 Port part

Claims (5)

A plurality of containers (I) formed by a resin film or sheet having a heat seal layer on at least one surface, and each formed with a weak seal portion provided by heat-sealing at least a part of the inner wall surface so as to be peelable; and (II) is a multi-chamber container obtained by separating and connecting each weak seal part so that they can communicate with each other, wherein the connecting part is an inner wall surface of one container (I) and the other container (II). Is formed by heat sealing with the outer wall surface of the container, and the inner wall surface of the container (I) is formed of a polyolefin resin,
The outer wall surface of the container (II) is composed of 10 to 60% by mass of the following (A) component obtained by the first stage polymerization and 90 to 40% by mass of the following (B) component obtained by the second stage polymerization. The content of the propylene unit in the total amount of the component (A) and the component (B) that contains the polymer as a main component and forms the sequential copolymer is 85 to 95% by mass, and the sequential copolymer The melting point peak temperature measured in accordance with JIS K7121 is 155 ° C. or higher, and the tensile yield stress measured in accordance with JIS K6921 of the sequential copolymer is 20 MPa or lower. ,
The inner wall surface of the container (II) contains the following component (C) and component (D) at a ratio of component (C): component (D) = 98: 2 to 50:50 (mass ratio). Formed of a polymer composition, and
The polyolefin resin forming the inner wall surface of the container (I) is a polyolefin resin containing linear low density polyethylene and / or cyclic polyolefin as a main component, or the component (C) and the component (D) ( C) component: (D) ingredient = 98: 2 to 50: 50 (multi-chamber container according to any der wherein Rukoto propylene copolymer composition in a proportion of weight ratio).
Component (A): A polymer component mainly composed of propylene having an isotactic index of 90% or more.
Component (B): It is composed of a copolymer of propylene and another α-olefin having 8 or less carbon atoms, containing propylene and ethylene as essential components, and components insoluble in xylene at room temperature are components (A) and ( B) Exceeding 20% by mass and 70% by mass or less of the total polymer combined with the component, and the component soluble in xylene at room temperature is 10% by mass in the total polymer combined with the component (A) and the component (B). A copolymer component having a content of α-olefin other than propylene in a component that is soluble in xylene at room temperature and is less than 20% by mass.
Component (C): a propylene-based copolymer component composed of propylene and ethylene and / or another α-olefin having 4 to 8 carbon atoms, and a temperature rising elution fractionation method (temperature: 0 to 140 ° C., solvent : O-dichlorobenzene), the proportion of elution at 0 ° C. is 15% by mass to 50% by mass and the proportion of elution at 60 ° C. to 90 ° C. A propylene-based copolymer component that is 5% by mass or more and less than 15% by mass with respect to the eluted amount.
Component (D): a propylene-based copolymer component composed of propylene and ethylene and / or another α-olefin having 4 to 8 carbon atoms, and a temperature rising elution fractionation method (temperature: 0 to 140 ° C., solvent : O-dichlorobenzene), the proportion of elution at 0 ° C. is 0% to 25% by mass and the proportion of elution at 60 ° C. to 90 ° C. A propylene-based copolymer component that is 15% by mass or more and 70% by mass or less with respect to the elution amount. The polypropylene resin forming the outer wall surface of the container (II) further comprises the above component (D) (sequential copolymer comprising (A) component and (B) component): (D) component = 98: 2-50: 50 multi-chamber container according to claim 1, wherein a proportion (mass ratio). At least a heat seal layer in which the weak seal portion provided on the inner wall surface of the container (I) is formed of a propylene-based copolymer composition containing the component (C) and the component (D) is used as a surface layer. The multi-chamber container according to claim 1 or 2 , wherein an easy peel tape provided is inserted between the inner wall surfaces of the container (I). The multi-chamber container according to any one of claims 1 to 3 , wherein the container (II) can be sterilized at 121 ° C. The multi-chamber container according to any one of claims 1 to 4 , wherein the container (I) contains a powdered medicine and the container (II) contains a liquid medicine.

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