JP4568627B2 - Oral composition - Google Patents

Description

  The present invention relates to an oral composition excellent in plaque and color removal effects.

As a dentifrice containing cellulose, a dentifrice composition containing cellulose powder having an average particle size of 0.005 to 1 mm is disclosed as an alternative to an abrasive (Patent Document 1). However, it cannot be said that such cellulose powder has sufficient plaque removal ability, and it has been proposed to blend granulated cellulose having an average particle size of 50 to 1000 μm instead (Patent Document 2).
JP 55-98111 A JP-A-9-40537

  However, even the granulated cellulose is not sufficient in terms of color removal, and it has been desired that it can be used as non-granulated cellulose from the viewpoint of production cost.

  An object of this invention is to provide the composition for oral cavity excellent in the plaque and the coloring removal effect.

As a result of diligent research to solve the problem, the present inventor has found that when a specific amount of powdered cellulose and an abrasive are added to the oral composition, the effect of removing plaque and coloring is enhanced, and the present invention is completed. It came to do.
That is, this invention provides the composition for oral cavity containing 10-30 mass% of abrasive | polishing agents and 0.2-3 mass% of powdered cellulose.

  According to the present invention, it is possible to provide an oral composition excellent in plaque and color removal effect.

The composition for oral cavity of the present invention contains an abrasive and powdered cellulose.
As the powdered cellulose used in the present invention, it is possible to use one or more kinds of pulp powder, insoluble powdered cellulose, powdered α-cellulose, pulverized one obtained by chemically treating cellulose such as pulp, and the like. it can. The average degree of polymerization of powdered cellulose is preferably 350 or more, more preferably about 350 to 2250, and still more preferably about 440 to 2550 in terms of plaque and color removal effects. The powdered cellulose is preferably non-granulated powdered cellulose having an average particle size of 10 to 300 μm, more preferably 10 to 100 μm, and particularly preferably 15 to 40 μm.

  The content of the powdered cellulose is 0.2 to 3% by mass with respect to the whole composition, and is preferably 0.4% by mass or more from the viewpoint of plaque and color removal effect. Is preferably 2% by mass or less, particularly 1% by mass or less.

When producing the composition of the present invention, the powdered cellulose may be blended as a powder or a dispersion liquid dispersed in a liquid such as water, lower alcohol, polyhydric alcohol or the like. Examples of the lower alcohol include ethanol and isopropanol. Examples of the polyhydric alcohol include glycerin, polyethylene glycol, and propylene glycol.

Can be illustrated. In the production, it is preferable to use a dispersion liquid dispersed in a liquid such as water, lower alcohol or polyhydric alcohol.

  The abrasive used in the present invention is not particularly limited as long as it is generally used in oral compositions, but silica-based abrasives such as precipitated silica, silica gel, aluminosilicate, gluconosilicate, second It is preferable to use calcium phosphate dihydrate and anhydrous, calcium pyrophosphate, calcium carbonate, alumina, aluminum hydroxide, magnesium acetate, tribasic magnesium phosphate, zeolite, synthetic resin-based abrasive, etc. May be used alone, or two or more may be used in combination.

From the standpoint of preventing the dentin from wearing, the polishing power of the abrasive, that is, RDA (Radio-active dentin abrasion) is preferably 20 to 200, more preferably 60 to 150.
Moreover, it is possible to reduce the former abrasive | polishing agent by using the abrasive | polishing agent whose RDA is 60-150 in combination with the abrasive | polishing agent of RDA exceeding 150 and 200 or less. In this case, the blending ratio (mass ratio) of the abrasive having an RDA of 60 to 150 and the abrasive having an RDA of more than 150 and 200 or less is preferably 1: 1 to 10: 1, more preferably 2: 1. ~ 8: 1.
Here, RDA uses the value measured for 10% abrasive slurry according to the method of Hefferren et al. (J. Dent. Res. 55, 1967, pp 563).

  Content of an abrasive | polishing agent is 10-30 mass% with respect to the whole composition, Preferably it is 12-25 mass%, More preferably, it is about 14-20 mass%.

  The blending ratio of the abrasive to the powdered cellulose in the composition of the present invention is preferably such that the content of the abrasive is 10 to 50 parts by mass, more preferably, when the content of the powdered cellulose is 1 part by mass. It is 25-40 mass parts.

  Although powdered cellulose itself has almost no polishing power, the action of the abrasive is remarkably enhanced by adding a small amount. This is considered to be due to the presence of powdered cellulose between the toothbrush bristle and the abrasive particles, which contributes to the interaction (friction) between the abrasive particles and the tooth surface. In addition, powdered cellulose is considered to work as a cushioning material, and is considered advantageous in that it exhibits selective detergency that removes coloration with little wear on the dentin of the teeth. In particular, when an abrasive having a low RDA is used, it is necessary to blend a large amount of an ordinary abrasive, but the amount of abrasive can be reduced by blending powdered cellulose.

  It is preferable to add a binder to the composition of the present invention. As a binder, for example, sodium alginate, sodium carboxymethyl cellulose, carrageenan, xanthan gum, sodium polyacrylate, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, It is preferable to blend two or more selected from the group consisting of psyllium seed gum, polyvinyl alcohol, sodium chondroitin sulfate, and methoxyethylene maleic anhydride copolymer. The content of the binder is usually about 0.1 to 3% by mass, preferably about 0.2 to 1.5% by mass, based on the entire composition.

  The composition of the present invention can be produced according to a conventional method except that powdered cellulose and an abrasive are essential.

  In addition to the above components, the toothpaste composition of the present invention contains, for example, foaming agents, foaming aids, wetting agents, sweeteners, pH adjusters, fragrances, preservatives, enzymes, bactericides, medicinal ingredients, pigments, dyes and the like. It can be contained as appropriate.

  As the wetting agent, glycerin, sorbitol, propylene glycol, polyethylene glycol, xylitol, maltite, lactit, trehalose and the like are preferably used.

  Examples of the sweetening agent include saccharin sodium, aspartame, thaumatin, acesulfame potassium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, and perilartin.

  Examples of the pH adjuster include phosphoric acid and salts thereof (sodium phosphate, sodium hydrogen phosphate, etc.), citric acid and salts thereof (sodium citrate, etc.), citric acid and salts thereof, phosphoric acid and salts thereof, apple Acid and its salt, Gluconic acid and its salt, Maleic acid and its salt, Aspartic acid and its salt, Gluconic acid and its salt, Succinic acid and its salt, Glucuronic acid and its salt, Fumaric acid and its salt, Glutamic acid and its Examples thereof include salts, adipic acid and salts thereof, hydrochloric acid, sodium hydroxide, potassium hydroxide, sodium silicate and the like. The content of the pH adjusting agent is not particularly limited as long as the desired pH is reached, but is usually about 0.01 to 5% by mass, preferably about 0.1 to 3% by mass with respect to the entire composition. The pH of the composition of the present invention is not particularly limited as long as the effect of the present invention is exhibited, but is usually about 4 to 10.

  As a fragrance, 1-menthol, carvone, anethole, eugenol, limonene, peppermint oil, spearmint oil, ocimen, n-amyl alcohol, citronellol, α-terpineol, methyl salicylate, methyl acetate, citronole acetate, cineol, linalool, Examples include ethyl linalool, crocodile, thymol, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, perilla oil, clove oil, and eucalyptus oil.

  Other various active ingredients include water-soluble phosphate compounds such as potassium phosphate and sodium salt of orthophosphoric acid, allantochlorohydroxyaluminum, hinokitiol, lysozyme chloride, glycyrrhizic acid and its salts, sodium chloride, tranexamic acid, epsilon. Aminocaproic acid, dl-tocopherol acetate, azulene, glycyrrhetinic acid, copper compounds such as sodium chlorophyllin, copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite, dextranase , Mutanase, amylase, methoxyethylene-maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterin, dihydrocholesterol, zinc citrate, Float, cork tree bark, clove, rosemary, scutellaria, an extract of such safflower, alpha-bisabolol, chlorhexidine salts, triclosan, cetylpyridinium chloride, benzethonium chloride, trichlorocarbanilide, and the like.

  Although content of water can be suitably set according to a dosage form etc., it is about 0-60 mass% normally with respect to the whole composition, Preferably it is about 10-50 mass%.

Examples of the anionic surfactant to be blended in the oral composition of the present invention include acylamino acid salts such as sodium acylglutamate and acylsarcosine sodium, alkylphosphates such as sodium alkylphosphate, alkylsulfate esters, and higher fatty acid sulfones. Monoglyceride salt, fatty acid ester salt of isethionic acid, N-methyl long chain acyl taurine sodium salt, polyoxyethylene monoalkyl phosphate, and the like. Hydrophobic alkyl group, acyl group has 6 to 18 carbon atoms, especially 10 to 14 are preferable, and sodium salt is preferable.

However, an alkyl sulfate ester salt is particularly preferred because it has good foaming properties and can be obtained at low cost.
The anionic surfactant is preferably contained in the oral composition of the present invention in an amount of 0.1 to 5% by mass, particularly 0.2 to 2% by mass.

Nonionic surfactants include, for example, polyoxyalkylene addition surfactants, amine oxide surfactants, mono- or diethanolamide surfactants, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, sucrose. Mention may be made of fatty acid esters. Among these, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, and sucrose fatty acid ester are preferable, and polyglycerin fatty acid ester such as monostearic acid decaglycerin and monomyristic acid pentaglycerin is particularly preferable. In the present invention, one or more of these can be used.
The content of the nonionic surfactant is preferably 1.2 to 3% by mass, more preferably 1.3 to 2.5% by mass, and particularly preferably 1.3 to 2% by mass in the composition for oral cavity of the present invention.

  EXAMPLES Hereinafter, although an Example and a comparative example are given and this invention is demonstrated in more detail, this invention is not limited to these Examples. Unless otherwise specified, “%” in the blending amount represents “mass%”.

Examples 1 to 10 and Comparative Examples 1 to 3
A toothpaste was prepared according to the formulation described in Table 1.
Using the obtained dentifrice, the color stain removal effect of the interdental part was tested. That is, as shown in FIG. 1, an interdental model made of aluminum blocks in which curved surfaces of R4 face each other was created, and a video tape magnetic layer was attached as a coloring model on the surface of the interdental model. Using the brushing machine shown in FIG. 2, the created interdental model was cleaned with each of the dentifrices of Examples 1 to 5 and the dentifrices of Comparative Examples 1 and 2.
The cleaning conditions were evaluated using a toothbrush (Kao product: Check Standard) with a load of 300 g, a speed of 120 rpm, an amplitude of 30 mm, and the number of times of cleaning of 120 times. The region of 2πR4 × width 5 mm was used as the evaluation region of the interdental portion, and after the brushing, the video tape magnetic layer was developed and photographed with a digital camera and image analysis was performed. By image analysis, the area (mm ² ) of the portion where the magnetic layer was peeled off and whitened in the evaluation region was calculated to evaluate the color stain removal rate at the interdental portion. The evaluation results are shown in Table 1. The evaluation result was expressed as a relative value of the removal rate with respect to the color removal effect of the interdental portion according to Comparative Example 1 as a reference (100%).

  As is clear from Table 1, Examples 1 to 5 in which powdered cellulose was blended showed an excellent intercolor tooth removal effect as compared with Comparative Example 1 that did not contain powdered cellulose. On the other hand, Comparative Example 2 containing crystalline cellulose improved the color removal effect at the interdental part, but the effect as excellent as powdered cellulose was not confirmed. In addition, Examples 6 to 11 described later have a high color removal effect at the interdental portion, and Comparative Example 3 had a low color removal effect at the interdental portion.

It is a conceptual diagram which shows the interdental model and interdental part evaluation area | region used for the coloring stain removal effect test of an interdental part. It is the schematic of a brushing machine.

Claims (6)

An oral composition containing 10 to 30% by mass of an abrasive and an average degree of polymerization of 440 to 2250 and 0.2 to 3% by mass of non-granulated powdered cellulose having an average particle size of 10 to 100 μm.   The composition for oral cavity according to claim 1, wherein the content of non-granulated powdered cellulose is 0.4-2% by mass.   The composition for oral cavity according to claim 1 or 2, wherein the content of the abrasive is 10 to 50 parts by mass when the content of the non-granulated powdered cellulose is 1 part by mass.   The oral composition according to any one of claims 1 to 3, wherein the abrasive has an RDA of 20 to 200.   The abrasive is a combination of an abrasive having an RDA of 20 to 150 and an abrasive having an RDA of more than 150 and not more than 200, and the blending ratio (mass ratio) is 1: 1 to 10: 1. The composition for oral cavity of any one of -4.   The composition for oral cavity according to any one of claims 1 to 5, wherein the content of the abrasive is 12 to 20% by mass.