JP4739766B2 - Manufacturing method of patch material and manufacturing method of patch preparation - Google Patents

Description

  The present invention relates to a patch preparation such as a wound dressing or a bandage and a patch preparation capable of continuously administering a drug into a living body through the skin.

  Various products have been proposed in which an adhesive is formed on one side of a nonwoven fabric or a plastic film as a product such as a patch or a patch preparation. These products are distributed and stored in a state where they are packaged in a packaging container such as a packaging film or box. However, the cohesive force of the pressure-sensitive adhesive may become insufficient depending on the type of pressure-sensitive adhesive used and the type and amount of additives such as liquid components added to the pressure-sensitive adhesive. In such a case, a problem that the adhesive flows out from the edge portion of these products during distribution and storage, a so-called “glue sticking” occurs. When the paste overflows, these products adhere to the inner surface of the packaging container, making it difficult to remove from the packaging container. If paste sticks out in the patch preparation, the drug flows out from the edge portion together with the adhesive, and as a result, the amount of the drug contained in the patch preparation decreases, which leads to a decrease in drug efficacy.

  An effective solution for the paste is to chemically cross-link the adhesive. Patent Document 1 describes a method of forming a chemical crosslink using an adhesive having a functional group capable of forming a chemical crosslink and a crosslinker. In Patent Document 2, as a method for introducing pseudo-crosslinking to a pressure-sensitive adhesive that does not have a functional group capable of forming a chemical crosslink, an isocyanate compound and a polyhydroxyalkylamine type are added to a styrene-butadiene rubber that is a rubber-based pressure-sensitive adhesive. A method of adding a compound is described.

As a measure for preventing the sticking out of the chemical crosslinking or pseudo-crosslinking, there is a method in which the adhesive is physically hardened by adding a high Tg component such as polymer rubber or a filler such as powder. Regarding the use of the filler, Patent Document 3 discloses a technique for dispersing short fibers in the adhesive layer of the tape in order to reduce the resistance when the tape is drawn, in other words, the unwinding force of the tape. . In addition, blister packs are also used to suppress glue sticking out by avoiding pressure on products during distribution and storage. However, the blister pack has an economical problem that the packaging film itself is thick and the material cost is high, and further, the blister pack is bulky and thus the storage cost and the distribution cost are high.
Japanese Patent No. 2700835 JP 2004-217860 A Japanese Utility Model Publication No. 7-40756

  However, the method described in Patent Document 1 uses a pressure-sensitive adhesive that does not have a functional group capable of forming a chemical crosslink due to physical properties, drug stability, economy, or the like. It cannot be applied when the agent cannot be used. Since the method of Patent Document 2 is a method of introducing pseudo-crosslinking by a chemical reaction, it cannot be applied depending on the type of additive or drug compounded in the pressure-sensitive adhesive. Moreover, if the adhesive is physically hardened by the addition of a filler, the adhesive force of the adhesive is reduced even if the adhesive sticking can be suppressed, and the product becomes difficult to use. As described above, it is difficult to achieve both suppression of sticking out and securing of adhesive strength.

  In view of such a situation, the present invention can be applied regardless of the type of adhesive, and adhesive paste is less likely to stick out, preferably less adhesive force is reduced, and is economically advantageous. It is an object to provide a patch preparation using the same.

As a result of intensive studies to solve the above-mentioned problems, the present inventors have included a network structure formed by partially bonding fibers in the pressure-sensitive adhesive layer. As a result, the present invention was completed.
The features of the present invention are as follows.
(1) and a support and pressure-sensitive adhesive layer provided on a support, viscous Chakuzaiso contains reticulated structure fibers each other is partially bonded to each other, said fibers, A patch that is present throughout the pressure-sensitive adhesive layer .
(2) The adhesive material according to (1) the viscosity Chakuzaiso is characterized in that it contains 0.1 to 10% by weight of the fiber.
(3) above textiles each other form a net-like structure was partially fused together (1) or adhesive material according to (2).
(4) The patch according to any one of (1) to (3), wherein the fiber is a heat-fusible fiber having a length of 0.1 to 10 mm.
(5) The heat-fusible fiber is a fiber made of polyolefin having a melting point of 70 to 150 ° C., or a sheath made of polyolefin having a melting point of 70 to 150 ° C. and a core made of polyester or polypropylene having a melting point higher than that of the sheath. The patch according to (4) above, which is a sheath-core type composite fiber having
(6) above (1) to in viscosity Chakuzaiso that put on any one of the patch of (5), a patch preparation the drug is to be contained.
(7) A method for producing a patch comprising a support and a pressure-sensitive adhesive layer provided on the support, the pressure-sensitive adhesive layer containing a network structure in which fibers are partially bonded to each other Because
Manufacturing a heat-sensitive adhesive layer in which heat-fusible fibers are dispersed to form a network structure in which the heat-fusible fibers are partially fused with each other in the pressure-sensitive adhesive layer Method.
(8) The production method according to (7), wherein the heat-fusible fiber has a length of 0.1 to 10 mm.
(9) A method for producing a patch preparation comprising the pressure-sensitive adhesive layer provided on the support, wherein the drug is contained in the production method according to (7) above.

  In the patch material and patch preparation of the present invention having the above-described configuration, the network structure contained in the pressure-sensitive adhesive layer effectively inhibits the flow of the pressure-sensitive adhesive composition, and has an effect of suppressing glue sticking. Since this effect is exhibited even if the concentration of the fiber contained in the pressure-sensitive adhesive layer is low, it is possible to achieve both strong adhesive force and suppression of sticking out of the paste. The present invention can be widely applied regardless of the type of the pressure-sensitive adhesive composition used as the matrix portion of the pressure-sensitive adhesive layer. The adhesive patch or adhesive preparation of the present invention is economically advantageous because it can be stored in a flat bag shape because it is difficult for glue to protrude from the edge portion. The product is easy to remove from the flat bag. The medicated patch of the present invention can reduce the loss of the drug accompanying paste sticking. Even when the patch or patch preparation is in the form of a roll, the effect of the present invention is exhibited, and the product can be easily taken out from a packaging container such as a bag or a box.

Hereinafter, the present invention will be described in detail with reference to the drawings. FIG. 1 is a perspective view of a patch of the present invention, and FIG. 2 is a perspective perspective view of an adhesive layer . Figure 2 depicts greatly stressed fibers 111 in the pressure-sensitive adhesive layer 11.
Patch 1 of the present invention, and a support member 10 and the pressure-sensitive adhesive layer formed on a supporting member 10, viscous Chakuzaiso 11 contains a net-like structure made of a fiber 111.

  In the present specification, the “patch” is a member to be affixed to human skin or other articles, “patch preparation” further containing a drug intended for administration by transdermal absorption, and does not contain the drug. It is a concept including a tape (for example, a supporter for protecting the skin, a tape for fixing a catheter to the skin, and the like).

<Adhesive layer>
Adhesive layer 11 of adhesive material 1 of the present invention is eclipsed set on one side of the support 10. Thickness tacky Chakuzaiso is not particularly limited, but is usually in the range of 10Myuemu～3mm.

The pressure-sensitive adhesive layer exhibits adhesive strength by a pressure-sensitive adhesive composition containing a pressure-sensitive adhesive and, if necessary, an additive or a crosslinking agent. Hereinafter, in the description of the structure, a portion made of the pressure-sensitive adhesive composition in the pressure-sensitive adhesive layer 11 is also referred to as a matrix portion 110.
The tacky Chakuzaiso 11 patch 1 of the present invention include reticulated structure. The network structure is a structure in which the fibers 111 dispersed in the matrix portion 110 are partially bonded to each other. The patch preparation of the present invention, the drug is contained in the pressure-sensitive Chakuzaiso.

<Adhesive composition>
The pressure-sensitive adhesive used in the pressure-sensitive adhesive composition is not particularly limited, and for example, a pressure-sensitive adhesive generally used for a patch that can be applied to human skin can be used. Specific examples include acrylic adhesives; rubber adhesives such as natural rubber and synthetic rubber; silicone adhesives; vinyl adhesives and the like. A pressure-sensitive adhesive having a functional group capable of forming a chemical crosslink such as a carboxyl group, a hydroxyl group, or an amino group may be used, or a non-functional pressure-sensitive adhesive having no such functional group may be used. The utility value of the present invention is high when a non-functional adhesive is used. When using a pressure-sensitive adhesive having a functional group capable of forming a chemical crosslink, it is not necessary to form a chemical crosslink. A crosslink or a pseudocrosslink may be formed. Even when a non-functional pressure-sensitive adhesive is used, pseudo-crosslinking may or may not be formed.

  The adhesive composition for forming the adhesive layer of the patch of the present invention may contain an additive in addition to the adhesive. The additive may be added for any purpose such as adjustment of adhesive physical properties, improvement of adhesive physical properties and drug stability, and improvement of drug absorption. The additive refers to a component other than the fibers 111 and the drug described later among the constituent materials of the pressure-sensitive adhesive layer and cannot itself adhere to human skin. Examples of the form of the additive at normal temperature include various forms such as powder, paste, and liquid. The kind of additive may be arbitrary, and may be single and may mix multiple types. Usually, the content of the additive in the pressure-sensitive adhesive layer is 0.01 to 70% by weight, preferably about 1 to 65% by weight. If the content of the additive is 0.01% by weight or more, the effect of blending can be expected easily. In the patch 1 of the present invention, since the paste is prevented from sticking out, a larger amount of additive can be contained in the adhesive layer than in the conventional patch. Additives for improving the absorbability and utilization rate of drugs are more effective as they are added in a large amount, and are preferable from the viewpoint of treatment and economy. When the content of the additive is 70% by weight or less, it is difficult to cause a decrease in adhesive force or a concern about adhesive residue on the skin surface after skin application.

<Reticulated structure>
At least one pressure-sensitive adhesive layer 11 of the patch 1 of the present invention contains a network structure in which the fibers 111 are partially bonded to each other.
The fiber 111 is a long structure made of a material different from the pressure-sensitive adhesive composition constituting the matrix portion 110. The cross section perpendicular to the major axis direction of the fiber 111 may be any shape such as a circle, an ellipse, a polygon, or a multi-leaf shape. Further, the fiber 111 may be a hollow fiber.

  The thickness of the fiber 111 is preferably 0.1 to 40 μm, more preferably 1 to 20 μm. If the thickness of the fibers 111 is 0.1 μm or more, the fibers 111 can contact each other with a sufficient area, so that the bonds between the fibers 111 become strong, and the network structure is difficult to break even when a force is applied from the outside. . If the thickness of the fiber 111 is 40 μm or less, the pressure-sensitive adhesive layer 11 has suitable flexibility, and unevenness or the like hardly occurs in the pressure-sensitive adhesive layer 11, which is preferable in terms of appearance. The thickness of the fiber 111 is defined by the diameter of a circle having an area equal to the cross-sectional area perpendicular to the major axis direction of the fiber 111. The thickness of the fiber 111 is the thickness of the portion that is not bonded to the other fiber 111. The thickness 112 of the portion 112 in which the fibers 111 are woven, the portion 112 in which the fibers 111 intersect and are bonded by an adhesive, and the portion 112 in which the fibers 111 intersect and are fused together Is not considered to be the thickness of the fiber 111. However, when the plurality of fibers 111 are in parallel contact without crossing and are integrated by binding, adhesive, welding, fusion, or the like (not shown), the integrated plurality of fibers are combined into one Considering the fiber 111, the thickness is derived. The thickness of the fiber 111 can be measured by observation with an electron microscope or a digital microscope, and can be expressed by an average value of 10 measurements.

  The length of each fiber 111 is not particularly limited, and is preferably about 0.1 to 10 mm. If the length of the fiber 111 is 10 mm or less, the orientation of the fiber 111 is difficult to be aligned when the adhesive solution for forming the adhesive layer 11 is applied, and a network structure can be formed efficiently. If the length of the fiber 111 is 0.1 mm or more, the mesh of the mesh structure will have an appropriate size, and it will be easy to ensure the adhesive strength.

  The material of the fiber 111 is not particularly limited and is typically an organic resin, and is preferably a material that can be heat-sealed to each other. The resin 111 used in the present invention is configured to be capable of being thermally fused to each other preferably at 70 to 150 ° C., more preferably at 110 to 150 ° C. Preferred examples include thermoplastic resins such as various polyethylenes (LDPE, LLDPE, HDPE), polypropylene, polyolefin, vinyl chloride, polyester, ethylene-vinyl acetate copolymer (EVA), and additives such as softeners to the thermoplastic resins. And various thermoplastic resins having different melting points. Non-thermoplastic fibers such as rayon and cotton may be used as the fibers 111 alone or in combination with a thermoplastic resin. The fiber 111 may be a homogeneous fiber made of a single material, or may be a composite fiber formed by combining a plurality of materials. Examples of the composite fiber include a sheath-core composite fiber, a parallel composite fiber, and a split composite fiber. In the pressure-sensitive adhesive layer 11, only one kind of the above-mentioned fibers may be present, or a plurality of kinds of fibers may coexist.

Content of the fiber 111 which occupies for the adhesive layer 11 becomes like this. Preferably it is 0.1 to 10 weight%, More preferably, it is 0.5 to 7 weight%. If the content is 10% by weight or less, the filling effect of the fibers 111 is hardly caused to the extent that the pressure-sensitive adhesive is cured to cause a decrease in the pressure-sensitive adhesive force. If the content is 0.1% by weight or more, it is sufficient for the formation of a network structure, so that the paste can be prevented from protruding. The content of the fibers 111 in the pressure-sensitive adhesive layer 11 is calculated for each pressure-sensitive adhesive layer 11 in which the network structure including the fibers 111 is included . Optimum content of textiles 111 can be appropriately selected depending on the thickness of the fibers 111 in the above-mentioned range. In the case of a constant weight fiber, the thinner the fiber, the longer the total length of all the fibers, and the fibers are easily bonded together. For example, if the fiber diameter is ½, it has a length four times that of the same weight fiber. Therefore, if the fiber 111 is thin, a net-like structure can be formed even with a smaller content, and paste can be prevented from protruding.

  In the present invention, that the fibers 111 are partially bonded means that the fibers 111 are bonded at the intersection 112 of the fibers 111, and the bonding mode is arbitrary, and the fibers 111 are knitted. Bonding by mechanical entanglement that is rare, entangled or caught, bonding by adhesive between fibers 111, bonding by fusing or fusing fibers 111, bonding by other methods may be used . Whether or not there is a bond between the fibers 111 can be determined by one of the following two methods. In the present invention, if it is recognized that the fibers 111 are bonded in at least one of the following two methods, the fibers 111 are considered to be partially bonded.

  The first method is a method of observing the entangled portion 112 of the fiber 111 in the pressure-sensitive adhesive layer 11 using a digital microscope or the like. It is obvious that the interlaced portions 112 of the fine thrusts are knitted, the protruding structures branched from the main axis of the fiber 111 such as the branch portions or the bearded portions of the fibers 111 are entangled or caught. When the adhesive 111 or the melt of the fiber 111 is clearly present as an observation image between the fibers 111 that are mechanically entangled or cross-contacted, it is recognized that the fibers 111 are bonded to each other. . The second method is a method of dissolving and removing the pressure-sensitive adhesive by solvent immersion. If the fibers 111 remaining after the pressure-sensitive adhesive layer 11 is immersed in a solvent capable of dissolving the pressure-sensitive adhesive are bonded in the solvent, it is recognized that the fibers 111 are bonded.

Fibers 111 in the present invention has only to be present as a network-like structure in viscosity Chakuzaiso 11, reticulated structures, Ru three dimensions der as in FIG. The mode of bonding between the fibers 111 is not particularly limited, and is preferably fusion. The fusion means that the materials constituting the fibers 111 are mixed and integrated at the joint portion 112 of the fibers 111, and typically includes heat fusion described later.

  The method for forming the network structure in the pressure-sensitive adhesive layer 11 is not particularly limited, and the following method can be preferably used. The adhesive solution in which the adhesive composition constituting the matrix portion 110 of the adhesive layer 11 is dissolved is added with the fibers 111 configured to be heat-bonded to each other and dispersed, and then the adhesive solution is supported. The pressure-sensitive adhesive layer 11 containing the fibers 111 can be formed by coating the body 10 and removing the solvent by drying. Alternatively, the pressure-sensitive adhesive solution can be applied onto a release liner and dried to form the pressure-sensitive adhesive layer 11, which can then be bonded to the support 10. By heating the pressure-sensitive adhesive layer 11 to a temperature at which the fibers 111 can be heat-sealed during or after the drying, the fibers 111 in the pressure-sensitive adhesive layer 11 can be partially heat-sealed. Examples of the fibers 111 configured to be heat-bonded to each other include fibers made of a thermoplastic resin, fibers made of a sheath component made of a thermoplastic resin, and more specifically, a melting point of 70 to Polyester, polypropylene, etc. that have fibers made of polyethylene or polyolefin at 150 ° C., a sheath and a core, and the sheath is made of polyethylene or polyolefin with a melting point of 70 to 150 ° C., and whose core has a higher melting point than the sheath And sheath-core type composite fibers made of If the melting point of the material of the whole fiber or the material of the sheath part of the sheath-core type composite fiber is 150 ° C. or less, the fibers 111 can be formed with a small amount of energy such that the support 10 and the film as the liner are hardly thermally deformed. It can be heat-sealed and is economically efficient. If the melting point is 70 ° C. or higher, the fiber 111 has a suitable strength, so that the strength of the network structure is ensured and a sufficient suppression effect of the glue sticking is expected, and the fiber 111 is cut and manufactured into a desired shape. Is preferable because it is easy. The method of heat treatment for heat fusion is not particularly limited, and examples thereof include use of an oven, a heat roll, ultrasonic irradiation and the like.

  As described above, in the present invention, the pressure-sensitive adhesive layer 11 containing the fibers 111 that can be partially heat-bonded to each other is formed on the support 10, and the pressure-sensitive adhesive layer 11 is heat-bonded to the fibers 111. A method for producing a patch comprising heating to a possible temperature.

Examples of a method for forming the network structure in the pressure-sensitive adhesive layer 11 include a method using a nonwoven fabric or a woven fabric in addition to the heat fusion between the fibers 111. Nonwoven fabrics and woven fabrics are obtained by subjecting fibers to mechanical entanglement, the use of adhesives, fusing and welding. Pieces or to such a nonwoven fabric or woven fabric sink into the adhesive layer 11 adhesive solution before after at and drying was applied to for formation of the adhesive layer 11, a non-woven fabric or woven with a knife A pressure-sensitive adhesive layer 11 containing a network structure can be obtained by coating the support 10 with a pressure-sensitive adhesive solution that has been cut into pieces and blended with the small pieces and dried . In here, the small pieces are formed by fibers which preferably is configured to be heat-sealed to each other. When such a small piece is used, the heat treatment as described above can be performed to heat-bond the small pieces of fibers 111 to form a larger network structure, and the effect of sticking out can be increased. Of course, it can also be expected that the paste will increase the effect of mechanical entanglement between the small pieces .

<Support>
The support of the adhesive material of the present invention is not particularly limited in material and shape as long as an adhesive layer can be formed thereon. The support is preferably formed of a material that does not easily allow liquid components contained in the pressure-sensitive adhesive layer or a drug described below to pass through. If such a material is used, it is difficult for the liquid component or drug to pass through the support, and the content is difficult to decrease. Preferred examples of the support include polyester, nylon, saran, polyethylene, polypropylene, ethylene-vinyl acetate copolymer, polyvinyl chloride, ethylene-ethyl acrylate copolymer, polytetrafluoroethylene, surlyn, metal foil, and the like. A single layer film or a laminate film of these may be used. In order to improve the adhesiveness (throwing property) between the support and the pressure-sensitive adhesive layer, the support is made of a laminate sheet of a non-porous sheet and a porous sheet made of the above materials, and the pressure-sensitive adhesive layer is formed on the porous sheet side. You can also. Such a porous sheet is not particularly limited as long as the anchoring property with the pressure-sensitive adhesive layer is improved, and examples thereof include paper, woven fabric, non-woven fabric, mechanically perforated sheet, and particularly, paper, A woven fabric and a nonwoven fabric are preferable.

<Drug>
The medicated patch of the present invention comprises a drug contained in at least one pressure-sensitive adhesive layer 11 in the aforementioned patch. Here, the drug only needs to be administrable to humans by transdermal absorption, and can be arbitrarily selected according to the therapeutic purpose of the patch preparation. Examples of drugs include corticosteroids, analgesic anti-inflammatory agents, hypnotic sedatives, tranquilizers, antihypertensive agents, antihypertensive diuretics, antibiotics, anesthetics, antibacterial agents, antifungal agents, vitamins, coronary vasodilation Agents, antihistamines, antitussives, sex hormones, antidepressants, cerebral circulation improving agents, antiemetics, antitumor agents, biopharmaceuticals and the like. The drugs may be used alone or in combination of two or more as required.

  From the viewpoint of uniform dispersibility, solubility or transdermal absorbability in the pressure-sensitive adhesive layer, it is preferable to use a fat-soluble drug having a solubility in 100 mL of water of 0.4 g or less at room temperature. The content of the drug can be appropriately set according to the type of drug and the purpose of administration, and is usually 0.1 to 70% by weight, preferably about 1 to 65% by weight in the pressure-sensitive adhesive layer. If the content is 0.1% or more, a therapeutically effective amount can be expected, and if it is 70% by weight or less, it is economically advantageous. When the patch preparation of the present invention has a plurality of pressure-sensitive adhesive layers, the content of the drug in the pressure-sensitive adhesive layer is calculated for each pressure-sensitive adhesive layer.

  EXAMPLES Hereinafter, although this invention is demonstrated in more detail using an Example, these examples do not limit this invention at all. In the following description, unless otherwise specified, parts and% mean parts by weight and% by weight.

[Example 1]
Polyisobutylene-based adhesive (Vexanex MML-140 manufactured by Exxon Chemical Co., Ltd./High Mall 6H manufactured by Nippon Petrochemical Co., Ltd./Arcon P100 = 40 parts / 30 parts / 30 parts) 73.5%, isopropyl myristate 24.5% % And 2% heat-fusible fiber (sheath core type composite fiber (core PET, sheath HDPE), diameter 16 μm, length 5 mm) were mixed and dispersed in toluene to obtain a pressure-sensitive adhesive solution. This pressure-sensitive adhesive solution was applied onto a polyester liner so that the thickness after drying was 120 μm, and dried at 100 ° C. to form a pressure-sensitive adhesive layer 11. A polyester film (thickness 12 μm) as the support 10 was bonded to the pressure-sensitive adhesive layer 11 and subjected to heat treatment at 140 ° C. to obtain a patch 1. In this patch, it is considered that the fibers 111 are present in the entire pressure-sensitive adhesive layer 11 as shown in FIG.

[Example 2]
74.25% polyisobutylene pressure-sensitive adhesive used in Example 1, 24.75% isopropyl myristate, and 1% of the heat-fusible fiber used in Example 1 were mixed and dispersed in toluene to obtain a pressure-sensitive adhesive solution. Got. Thereafter, the patch 1 was obtained in the same manner as in Example 1.

Example 3
71.25% polyisobutylene pressure-sensitive adhesive used in Example 1, 23.75% isopropyl myristate, and 5% heat-fusible fiber used in Example 1 were mixed and dispersed in toluene to obtain a pressure-sensitive adhesive solution. Got. Thereafter, the patch 1 was obtained in the same manner as in Example 1.

Example 4
A patch 1 was obtained in the same manner as in Example 1 except that a sheath-core type composite fiber (core PP, sheath HDPE, diameter 15 μm, length 5 mm) was used as the heat-fusible fiber.

Example 5
A patch 1 was obtained in the same manner as Example 1 except that a fiber (diameter: 17 μm, length: 5 mm) made only of HDPE was used as the heat-fusible fiber.

[Example 6 ]
63.75% polyisobutylene pressure-sensitive adhesive used in Example 1, 21.25% isopropyl myristate, and 15% of the heat-fusible fiber used in Example 1 were mixed and dispersed in toluene to obtain a pressure-sensitive adhesive solution. Got. Thereafter, the patch 1 was obtained in the same manner as in Example 1.

[Example 7 ]
70.6% acrylic ester polymer obtained by copolymerizing 97 parts 2-ethylhexyl acrylate and 3 parts acrylic acid under inert gas atmosphere, 24.5% isopropyl myristate, lidocaine (drug ) 2.9% and 2% of the heat-fusible fiber used in Example 1 were mixed and dispersed in ethyl acetate to obtain an adhesive solution. Thereafter, a patch (a patch preparation) 1 was obtained in the same manner as in Example 1.

[Comparative Example 1]
The polyisobutylene pressure-sensitive adhesive 75% and isopropyl myristate 25% used in Example 1 were dissolved in toluene to obtain a pressure-sensitive adhesive solution. A patch was obtained in the same manner as in Example 1 except that this pressure-sensitive adhesive solution was used and heat treatment at 140 ° C. was not performed.

[Comparative Example 2]
A patch was obtained in the same manner as in Comparative Example 1 and further heat treated at 140 ° C.

[Comparative Example 3]
A patch was obtained in the same manner as in Example 1 except that the heat treatment at 140 ° C. was not performed.

[Comparative Example 4]
A patch was obtained in the same manner as in Example 2 except that the heat treatment at 140 ° C. was not performed.

[Comparative Example 5]
A patch was obtained in the same manner as in Example 3 except that the heat treatment at 140 ° C. was not performed.

[Comparative Example 6]
A patch was obtained in the same manner as in Example 4 except that the heat treatment at 140 ° C. was not performed.

[Comparative Example 7]
A patch was obtained in the same manner as in Example 5 except that the heat treatment at 140 ° C. was not performed.

[Comparative Example 8]
A patch preparation was obtained in the same manner as in Example 7 except that heat treatment at 140 ° C. was not performed.

[Comparative Example 9]
The pressure-sensitive adhesive solution was obtained by dissolving 72% acrylic ester polymer, 25% isopropyl myristate and 3% lidocaine (drug) used in Example 7 in ethyl acetate. Thereafter, a patch (a patch preparation) was obtained in the same manner as in Example 1.

[Comparative Example 10]
A patch preparation was obtained in the same manner as in Comparative Example 9 except that heat treatment at 140 ° C. was not performed.

[Fiber binding]
A small piece of each patch and patch preparation was immersed in a solvent capable of dissolving the adhesive, and it was visually confirmed whether or not the fibers were bound.

(Adhesion measurement)
A band-like sample obtained by cutting each patch and patch preparation to a width of 24 mm was stuck to a bakelite plate, and a roller with a load of 850 g was reciprocated once to bring it into close contact. Thereafter, the sample was peeled off at a speed of 300 mm / min in the 180 degree direction, and the peeling force at that time was regarded as the adhesive force (N / 24 mm).

[Measurement of glue sticking out]
Each patch and patch preparation was punched out to a size of 2.5 cm ² , and the length of the paste protruding from the edge when measured for 7 days at 50 ° C. with a weight of 35 g was measured. The maximum lengths were compared.

  The results of the above measurements are shown in Table 1 for the patch and Table 2 for the patch preparation.

Ru perspective view der the patch of the present invention. It is a perspective perspective view of the adhesive layer of the patch of the present invention .

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Adhesive material 10 Support body 11 Adhesive layer containing network structure
1 10 Matrix part 111 Fiber 112 Fiber bonding part

Claims (3)

And a pressure-sensitive adhesive layer provided on the support, and the pressure-sensitive adhesive layer is a method for producing a patch containing a network structure in which fibers are partially bonded to each other. ,
Manufacturing a heat-sensitive adhesive layer in which heat-fusible fibers are dispersed to form a network structure in which the heat-fusible fibers are partially fused with each other in the pressure-sensitive adhesive layer Method. The length of the heat-fusible fibers, the manufacturing method according to claim 1 is 0.1 to 10 mm. In the production method according to claim 1, the adhesive layer provided on a support, a manufacturing method of the patch preparation formed by incorporating a drug.

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