JP4875407B2 - When mixing container - Google Patents

Description

  The present invention relates to an in-use mixing container capable of separating and storing a lyophilized solid drug and a solvent or a dispersion medium, and mixing and using both at the time of use.

As this type of conventional mixing container, the applicants of the present application have conventionally developed the container disclosed in Japanese Patent Application Laid-Open No. 2004-18019. By storing the solid preparation and the liquid in separate containers, respectively, it is possible to maintain the sealed state of the mouth of the liquid container in particular until the containers are connected for mixing at the time of use. It is possible to reliably perform the mixing work at the time of use without spilling.
JP 2004-18019 A

  This conventional on-use mixing container includes a vial, a stopper removably attached to the mouth of the vial so as to seal the internal space of the vial from the outside air, a plastic bottle, and the mouth of the bottle. And a cap attached to the part. The cap has a guide member that is liquid-tightly attached to the mouth portion of the bottle, and a connection member that has a connection mouth portion that can be connected in a liquid-tight manner to the mouth portion of the vial and that fits the guide member in a liquid-tight manner. With. The connection member is directed from the first position where the internal space of the bottle is sealed from the outside air by the first and connection members to the guide member toward the second position positioned inward in the axial direction of the bottle from the first position. Are relatively movable. In addition, when the connecting member is in the second position, a communication path that connects the internal space of the vial connected to the connection port of the connecting member and the internal space of the bottle is formed in the cap. ing.

  According to the above-mentioned mixing container, at the time of distribution or storage, a solid component such as a freeze-dried preparation is stored in a sterile state in a vial, and the bottle is a liquid component that serves as a solvent or dispersion medium for the solid component. Can be stored in a sterile condition. In order for the patient or his / her attendant to mix the solid component and the liquid component at the time of use, first, the stopper is removed from the mouth portion of the vial, and the mouth portion opened upward is turned upside down. Connect the connection port of the connecting member of the bottle. At this time, since the connecting member is still in the first position and the mouth of the bottle is kept sealed, the liquid component in the bottle will not be spilled. Next, when the bottle with the connection port connected to the mouth of the vial is pushed in toward the vial, the connection member moves from the first position to the second position by being pushed by the vial, so that the inside of the cap The communication path is formed in the bottle, and the liquid component in the bottle can be transferred to the vial without spilling through the communication path. Then, after mixing (dissolving or dispersing) sufficiently, if the bottle is formed with the vial and the bottle connected, all of the liquid mixture from the inside of the upside down vial passes through the communication path into the bottle. It is transferred. Then, by removing the vial bottle and the cap from the mouth of the bottle and attaching a discharge device such as an eye drop nozzle or a pump spray device to the mouth of the bottle, the bottle can be used as a discharge container for the mixed liquid agent. .

  The invention of the present application further facilitates the flow of the liquid agent in the communication path when the liquid agent is transferred between the vial and the bottle in the above-described mixing container, and performs the mixing operation and the operation of filling the chemical liquid into the bottle. The purpose is to enable quick and reliable execution.

  The present invention includes a first container having a first mouth part, a second container having a second mouth part, and a connection member for connecting the first mouth part and the second mouth part. The connecting member moves from the first position sealing the second mouth part to the second mouth part toward the second position located inward in the axial direction of the second mouth part from the first position. The connecting member is attached to the second mouth part so as to be relatively movable, and the connection member includes a cylindrical connection mouth part detachably attached to the first mouth part, and the connection port part. A connecting cylinder portion provided in the axially inward direction; and a plug provided in the axially inward direction of the connecting cylinder portion, wherein the connecting cylinder portion has first and second openings that open radially outward. 2 openings are provided, the first and second openings are arranged in the circumferential direction, and when the connecting member is in the first position, the second mouth is sealed by the plug, and the connecting member is Second position When the first and second openings are opened in the internal space of the second container, the internal space of the first container and the internal space of the second container communicate with each other through the internal space of the connecting cylinder. In the mixing container, the axially inward end portion of the first opening and the axially inward end portion of the second opening are in positions shifted in the axial direction. Is.

  According to the present invention, the liquid flow flowing between the first container and the second container is unbalanced, so that the liquid flow can be prevented from stagnation due to the surface tension.

  In the above-mentioned mixing container for use according to the present invention, a plate for partitioning the internal space of the connection cylinder portion into the first communication path communicating with the first opening and the second communication path communicating with the second opening is provided in the connection cylinder portion. May be provided. According to this, it can prevent that the liquid flow which flows in from the 1st and 2nd opening part interferes, and can attain smoothing of the further liquid flow. This plate is preferably provided over the entire length in the axial direction of the connecting cylinder part, but can also be provided only in a part in the axial direction of the connecting cylinder part. Moreover, the said board may protrude in the front end side rather than the end surface of the connection port part provided in the axial direction outer end of the connection cylinder part.

  Moreover, it is preferable that the axially outer side surface of the plug constitutes the axially inner ends of the first and second openings. In this case, the outer surface of the plug is preferably a tapered surface. According to this, the liquid flow flows more smoothly along the tapered surface. Furthermore, by making the taper angle of the plug outer surface on the first opening side different from the taper angle of the plug outer surface on the second opening side, the balance of the liquid is made different from that of the first opening side. It can be further broken down on the second opening side, and the stagnation of the liquid flow due to the surface tension can be further prevented.

  Preferably, a guide member detachably attached to the second mouth portion can be further provided. The guide member may include a cylinder fitted in the second mouth portion, and when the connecting member is in the first position, the plug fits in the cylinder in a liquid-tight manner so that the second mouth portion is fitted. It is preferable that the first and second openings are opened in the internal space of the second container by detaching the plug axially inward from the cylinder when the connecting member is in the second position. .

  According to the present invention, when the first container and the second container are connected at the time of use to mix the solid component and the liquid component, the liquid component does not become zero, and it is ensured at a predetermined mixing ratio. A liquid mixture can be produced and can be handled hygienically. In addition, after performing the mixing operation, the mixed solution can be accommodated in the second container, and a discharge device can be attached to the container and used as a discharge container such as a spray container. The mixing at the time of use can be performed accurately while aiming at the reduction of. Furthermore, the flow of the liquid agent in the communication path when the liquid agent is transferred between the first container and the second container is made smoother, so that the mixing operation and the work of filling the chemical liquid into the bottle can be performed quickly and reliably. become.

  Hereinafter, preferred embodiments of the present invention will be described with reference to the drawings.

  1 to 7 show an in-use mixing container according to an embodiment of the present invention, and the in-use mixing container is a vial 1 (first container) for containing a solid component comprising a freeze-dried preparation. And a resin bottle 2 (second container) for containing a liquid component serving as a solvent or dispersion medium for the solid component. The liquid component itself may contain an active ingredient. This container can be suitably used as, for example, a dissolution-type nasal drop pump spray container for use, and can be used for other appropriate applications.

  The vial bottle 1 is made of glass, and integrally includes a cylindrical mouth portion 4 (first mouth portion) at the upper end of a bottomed cylindrical body portion 3. A rubber stopper such as butyl rubber is fitted into the mouth 4 in a liquid-tight manner before use. In addition, in order to prevent the plug body 5 from being accidentally detached and to improve the airtightness, a lid member (rubber plug presser) can be crowned so as to cover the plug body.

  In the bottle 2, a cylindrical mouth portion 22 (second mouth portion) is integrally formed at the upper end of a bottomed cylindrical body portion 21. A bottomed cylindrical base 23 is attached to the lower part of the bottle 2. The bottle 2 is formed so that the body portion 21 at the center in the axial direction bulges outward in the radial direction and gradually decreases in diameter as it moves from the center in the axial direction to the bottom side. The mouth portion 22 at the upper end of the bottle 2 has a cylindrical shape that opens upward.

  A cap 50 mainly composed of a cylindrical guide member 51 and a cylindrical connection member 52 is attached to the mouth portion 22 of the bottle 2 of the present embodiment, and the bottle 2 filled with a liquid component is transported. During storage or the like, the cap 22 seals the mouth portion 22 in an airtight and liquid-tight manner, while in use, the cap 50 is used as a connection adapter with the vial 1 for easy and reliable mixing of two agents. I can do it.

  The guide member 51 is a cylindrical first tube portion 51a that is screwed to the outer peripheral side of the bottle mouth portion 22, and is integrally connected to the first tube portion 51a via a flange portion 51e and is a first tube portion. A cylindrical second cylindrical portion 51b (cylinder) positioned radially inward of 51a, a cylindrical third cylindrical portion 51c connected to an axial end of the first cylindrical portion 51a, and the third The main part is composed of a substantially cup-shaped holder part 51d connected to the axial end of the cylinder part 51c. On the inner peripheral surface of the first tube portion 51a, a screw portion that is screwed into the screw portion 22a on the outer periphery of the bottle mouth portion is provided. The inner diameter and the outer diameter of the second cylinder portion 51 b are smaller than the inner diameter of the bottle mouth portion 22, and the second cylinder portion 51 b is inserted into the bottle mouth portion 22 in the illustrated example. The lower surface of the flange portion 51 e is opposed to the upper surface of the bottle mouth portion 22. A rubber packing 53 is interposed between the flange portion 51 e and the bottle mouth portion 22 in order to ensure liquid tightness and air tightness between the guide member 51 and the bottle mouth portion 22.

  The third cylinder part 51c is configured to be fitted onto the mouth part 4 of the vial 1, and when the third cylinder part 51c is fitted onto the mouth part 4, as shown in FIG. An engaging convex portion 54 that engages with the proximal end portion of the flange portion 7 in the axial direction is provided on the inner peripheral surface of the third cylindrical portion 51c. Further, as shown in FIGS. 2 and 3, the third cylindrical portion 51c is formed with a slit 55, and the tongue piece 57 provided at a predetermined circumferential portion of the third cylindrical portion 51c is elastically deformed radially outward. On the inner surface of the tongue piece 57, an engagement convex portion 58 that engages with a flange portion 52d described later in the axial direction is provided. The holder part 51d is shaped to fit the shape of the shoulder part and the body part of the vial 1 and when the third cylinder part 51c is fitted on the mouth part 4, the vial part 1 is formed by the inner peripheral surface of the holder part 51d. It is possible to hold the outer peripheral surface of the upper side.

  As shown in FIGS. 4 and 5, the connection member 52 includes a cylindrical connection port 52 a that is fitted in a liquid-tight and air-tight manner in the mouth 4 of the vial 1, and a continuous connection to the connection port 52 a. A cylindrical connecting tube portion 52b fitted in the second tube portion 51b so as to be slidable in the axial direction, and the second tube portion integrally provided at an end portion in the axial direction of the connecting tube portion 52b. A plug 52c fitted into the axial base end portion of 51b, a flange portion 52d formed radially outward from the axial base end portion of the connection port 52a, and a shaft central portion of the plug 52c. It is mainly composed of a center plate 52e extending toward the tip end in the axial direction. These components are integrally formed, and the plug 52c is also integrally formed with the connection member 52, so that the number of parts can be reduced, and the manufacturing cost can be reduced.

  The center plate 52e is provided over the entire length of the connecting cylinder portion 52b in the axial direction, and the front end portion of the center plate 52e protrudes from the front end of the connection port portion 52a in the illustrated embodiment. Is not particularly limited. The center plate 52e can prevent the liquid flows flowing from first and second openings 56a and 56b, which will be described later, from interfering with each other, and helps to further smooth the liquid flow.

  The connecting member 52 is located in the axially inward direction of the bottle 2 from the first position from the first position (see FIG. 4) where the guide member 51 and the connecting member 52 seal the internal space of the bottle 2 from the outside air. When it is movable relative to the guide member 51 and the bottle opening 22 toward the position (see FIG. 5) and the connecting member 52 is in the second position, the connecting opening 52a of the connecting member 52 A communication path that connects the internal space of the connected vial 1 and the internal space of the bottle 2 is formed in the cap 50. Further, when the connecting member 52 is in the first position, the flange 52d engages with the engaging convex portion 58 of the tongue piece 57 of the guide member 51 in the axial direction, so that the connecting member 52 is inadvertently pushed. Is preventing. When the connecting member 52 is pushed in strongly, the tongue piece 57 is deformed, so that the engagement between the flange portion 52d and the engaging convex portion 58 is released, and the connecting member 52 is pushed toward the second position.

  More specifically, two openings 56a and 56b penetrating inward and outward are provided on the peripheral wall in the vicinity of the connection end portion of the connection cylinder portion 52b with the plug 52c. In the present embodiment, axially inner ends of the openings 56a and 56b are configured by the axially outer surface of the plug 52c. And when the connection member 52 moves to the 2nd position, each opening part 56a, 56b will be exposed to the inner side of the bottle 2 rather than the base end part of the 2nd cylinder part 51b, and the said communicating path will be opened. It has become. On the other hand, when the connection member 52 is in the first position, the opening 56 is housed inside the second cylinder portion 51b, and the plug 52c can close the communication path. Note that the number of openings may be at least two, and three or more openings may be formed.

  Further, the axially outer surface of the plug 52c is a tapered surface, and the taper angle of the plug outer surface on the one opening 56a side is different from the taper angle of the plug outer surface on the other opening 56b side. Yes. Such a configuration also helps to break the balance of the liquid flowing between the bottle 2 and the vial 1 and prevent the occurrence of surface tension.

  The openings 56 are provided on the left and right sides of the center plate 52e, respectively, and the axially inner ends of the left and right openings 56a, 56b are in positions shifted in the axial direction, and the openings 56a, The opening area of 56b is formed to be different. Thereby, the balance of the liquid flow which flows between the bottle 2 and the vial bottle 1 can be lost, and it can be prevented that the liquid flow is stagnated due to the generation of surface tension.

  Further, the flange portion 52 d of the connection member 52 is fitted into the third tube portion 51 c of the guide member 51. When the connecting member 52 is in the first position, the flange portion 52d is engaged with the engaging convex portion 54 in the axial direction, thereby preventing the connecting member 52 from moving to the second position. As described above, since the predetermined portion in the circumferential direction of the third tube portion 51c can be elastically deformed radially outward, when the vial 1 connected to the connection port portion 52a is strongly pushed in, the third tube is formed by the flange portion 52d. Since the portion 51c is forcibly expanded outward in the radial direction and the engagement between the flange portion 52d and the engagement convex portion 54 is released, the relative movement to the second position becomes possible.

  A cover cap 45 is attached to the front end of the holder portion 51d to prevent the inner surfaces of the guide member 51 and the connection member 52 from being contaminated. Further, the cover cap 45 is formed in a cup shape, and the bottom thereof is close to the tip of the connecting member 52 in the first position, and the connecting member 52 is inadvertently moved outward in the axial direction of the bottle. The position is prevented from shifting.

  The inner surface in the axial direction of the plug 52c is formed in a tapered shape in order to minimize the residual liquid flowing into the bottle 2 from the vial bottle 1 as much as possible.

  Next, the mixing process of the above-mentioned in-use mixing container will be described with reference to FIGS.

  2 and 3 show the delivery form of the product, that is, the state of the bottle 2 during transportation and storage. When using, first, the lid member and the stopper are removed from the mouth portion 4 of the vial bottle 1 and the cover cap 45 of the bottle 2 is removed similarly to the other embodiments described above. Next, as shown in FIG. 4, the bottle 2 is turned upside down, and the connection opening 52 a is pushed into the opening 4 of the vial 1 to connect both containers 1 and 2. Next, when the bottle 2 is further pushed in, as shown in FIG. 5, the connecting member 52 moves in the axial direction relative to the guide member 51, and the opening 56 is exposed to the inner space of the bottle. A communication path is formed in 50 to connect the internal space of the vial 1 and the internal space of the bottle 2, and the liquid component in the bottle 2 flows into the vial 1 through the communication path.

  After sufficiently mixing the solid component and the liquid component, when the whole is turned upside down and the bottle 2 is positioned on the lower side and the vial bottle 1 is positioned on the upper side, all of the liquid mixture flows into the bottle 2. Then, the cap 50 is removed from the bottle mouth portion 22 together with the vial bottle 1 by holding the holder portion 51 d and rotating the entire guide member 51. Then, a discharge device 50 such as a pump spray device prepared separately is attached to the bottle mouth portion 22 as shown in FIGS. 6 and 7, so that the bottle 2 used as a liquid component container before mixing can be obtained. It can be used as a discharge container.

  FIGS. 8-14 has shown the mixing container for use which concerns on other embodiment of this invention, Since a structure and an effect are the same as that of the said embodiment, the same code | symbol is attached | subjected and detailed description is abbreviate | omitted.

It is a longitudinal cross-sectional view which shows the bottle and cap of the in-use mixing container which concern on one Embodiment of this invention. It is the whole bottle and cap front view. It is the whole bottle and cap side view. It is a longitudinal cross-sectional view which shows the use mixing process of the same use mixing container. It is a longitudinal cross-sectional view which shows the use mixing process of the same use mixing container. It is a whole front view of the use condition after use mixing of the same time use mixing container. It is a whole side view of the use condition after use mixing of the same time use mixing container. It is a longitudinal cross-sectional view which shows the use mixing process of the use mixing container which concerns on other embodiment of this invention. It is a front view of FIG. It is a side view of FIG. It is a longitudinal cross-sectional view which shows the use mixing process of the use mixing container which concerns on other embodiment. It is a front view of FIG. It is a side view of FIG. It is a three-plane figure which shows the use condition of the in-use mixing container which concerns on other embodiment.

Claims (6)

A first container having a first mouth, a second container having a second mouth, and a connection member for connecting the first mouth and the second mouth, the connection member Is relative to the second mouth from the first position sealing the second mouth toward the second position located axially inward of the second mouth from the first position. The connection member includes a cylindrical connection port portion that is detachably mounted on the first port portion, and a second port shaft of the connection port portion. A connecting tube portion provided inwardly in the direction and a plug provided in the axially inward direction of the connecting tube portion, wherein the connecting tube portion includes first and second openings that open radially outward. The first and second openings are disposed in the circumferential direction. When the connecting member is in the first position, the second mouth is sealed by the plug, and the connecting member is In position 2 When the first and second openings open into the internal space of the second container, the internal space of the first container and the internal space of the second container communicate with each other through the internal space of the connecting cylinder. In the container,
And the axial inner end of the first opening, and the axial inner end of the second opening, Ri position near the axially offset,
A plate for partitioning the internal space of the connecting cylinder part into a first communicating path communicating with the first opening and a second communicating path communicating with the second opening is provided in the connecting cylinder part. When used for mixing containers. The in-use mixing container according to claim 1 , wherein the plate is provided over the entire length in the axial direction of the connecting tube portion. The in-use mixing container according to claim 1 or 2 , wherein the axially outer surface of the plug constitutes the axially inner ends of the first and second openings. When used as a mixing container. The use mixing container according to claim 3 , wherein an outer side surface of the plug is a tapered surface. The use mixing container according to claim 4 , wherein a taper angle of the plug outer surface on the first opening side is different from a taper angle of the plug outer surface on the second opening side. When used for mixing containers. The use mixing container according to any one of claims 1 to 5 , further comprising a guide member detachably attached to the second mouth portion, and the guide member is fitted into the second mouth portion. And when the connecting member is in the first position, the plug is liquid-tightly fitted in the cylinder to seal the second mouth, and when the connecting member is in the second position, the plug is the cylinder. An in-use mixing container characterized in that the first and second openings are opened in the internal space of the second container by detaching inward in the axial direction.

Images