JP5264106B2 - Composition having antioxidative action - Google Patents

Abstract

[PROBLEMS] To provide: a composition having an excellent antioxidative activity; a food or beverage utilizing the composition; and a method for producing the composition. [MEANS FOR SOLVING PROBLEMS] Disclosed are: a composition comprising a processed product of a plant belonging to Cistache Tsubulosa (so-called "Kanka") and a processed product of a plant belonging to Withania sominifera (so-called "Ashwagandha"), wherein the composition may further comprise a processed product of a plant belonging to Panax ginseng and/or a processed product of a plant belonging to Lepidium meyanii; a food or beverage produced by using the composition; a method for producing the composition; and a method for increasing the antioxidative activity of a plant belonging to Cistache Tsubulosa.

Description

  The present invention relates to a composition containing an Ashwagandha processed product and a processed Kanka product.

It is known that about 1 to 2% of oxygen taken in by living organisms becomes active oxygen in the body. In addition to breathing, smoking, stress, ultraviolet rays, exhaust gas, and the like are known as causes for generating active oxygen. In addition, it is said that it is caused by oral intake of agricultural chemicals, dioxins, drugs, and the like. Active oxygen generated excessively in the body damages cells and tissues (oxidative stress), and causes various diseases such as arteriosclerosis, inflammatory reaction, and diabetes. Living organisms usually have substances that have anti-acid activity (antioxidants) to protect against such adverse reactions of active oxygen, but antioxidant activity is greatly affected by age and stress, and the activity is significantly reduced. There are things to do. Therefore, in recent years, for the purpose of improving the antioxidant activity, supplements, beverages and the like having an antioxidant action have been actively developed (for example, Patent Document 1). From such a background, development of foods and drinks and the like having further excellent antioxidant action is desired.
JP-A-6-9417

  The main object of the present invention is to provide a composition having an excellent antioxidant action, a food and drink using the composition, a method for producing the composition, and a method for enhancing antioxidant power.

  The present inventors have intensively studied to solve the above problems. Conventionally, Kanka and Ashwagandha have been known to have an antioxidant effect, but the present inventors used a combination of Kanka processed product and Ashwagandha processed product than when each processed product was used alone. It has been found that the antioxidant effect is improved. In addition, the present inventors have confirmed that a further excellent antioxidant action can be achieved by blending a Korean-participated product and a maca processed product in addition to the processed Ashwaganda product and the processed Kanka product. The present invention has been completed as a result of further research based on such knowledge.

That is, the present invention provides the following inventions:
Item 1. A composition containing an Ashwagandha processed product and a processed Kanka product.
Item 2. Item 2. The composition according to Item 1, wherein the processed product is any one selected from the group consisting of a pulverized product, a dried product, and a solvent extract.
Item 3. Item 3. The composition according to Item 1 or 2, comprising 3 parts by weight or more of Ashwagandha processed product with respect to 100 parts by weight of processed Kanka.
Item 4. Item 4. The composition according to any one of Items 1 to 3, further comprising a Korean participant work and / or a processed maca product.
Item 5. Item 5. The composition according to any one of Items 1 to 4, which is an oral composition.
Item 6. Item 6. The composition according to any one of Items 1 to 5, which is in the form of a food or drink.
Item 7. A method for enhancing the antioxidant power of kanka, which comprises blending a processed ashwaganda product with a processed kanka product.

  The composition of this invention can exhibit the outstanding antioxidant effect by containing a Kanka processed material and an Ashwagandha processed material. Moreover, the composition of this invention exhibits the more superior antioxidant effect by mix | blending the said predetermined amount with Kankan processed material and Ashwagandha processed material. The composition of the present invention can exhibit a further excellent antioxidation effect by using, in addition to the Kanka processed product and the Ashwagandha processed product, the Korean Participating Product and / or Maca Processed Product.

  The composition of the present invention is effective for the prevention and alleviation of symptoms such as lifestyle-related diseases, arteriosclerosis, and liver function deterioration caused by the adverse reaction of active oxygen due to the excellent antioxidant action.

  Since the composition of the present invention can be prepared in various food and drink forms as an oral composition, it can be easily taken continuously and is effective in preventing and alleviating the above symptoms. Moreover, by taking the composition of the present invention on a daily basis, excellent effects such as beautiful skin, prevention of aging, nourishing tonic, recovery from fatigue, and the like can be obtained.

  In addition, according to the method for enhancing antioxidant power of the present invention, the antioxidant power inherent in kanka can be further enhanced by blending the processed ashwaganda into the processed kanka. Moreover, according to the method of the composition having an antioxidant action of the present invention, the composition of the present invention can be easily obtained.

  The composition of the present invention contains a specific processed plant product in combination. Hereinafter, each component of the composition of this invention is explained in full detail.

(1) Composition The processed product included in the present invention is made from the following plants.

(i) Kanka Kanka (also known as Chinese Desert Ginseng) is also called Kankaniku Juyo, belongs to the crested crabs (scientific name: Cistache Tsubulosa), and parasitizes in the roots of red willow (Tamarix) growing in the desert in nature. As processed kanka, kanka extract powder (Eijin Shoji Co., Ltd.) and the like can be obtained commercially.

(ii) Ashwagandha Ashwagandha (also known as Indian ginseng), also called winter cherry or swordfish, belongs to the eggplant family (scientific name: Withania sominifera) and grows naturally in dry areas such as India and Nepal in nature. Sometimes cultivated on the Mediterranean coast. Ashwagandha powder W (Nippon Shinyaku Co., Ltd.) etc. can be obtained commercially as processed Ashwaganda.

(iii) Ginseng (also known as ginseng) Ginseng is also called ginseng or ginseng, and it is also called white ginseng, red ginseng, ginseng, or ginseng depending on the processing method. It belongs to the aralia family (scientific name: Panax ginseng) and is cultivated in the northeastern part of China, or in the northeastern part of China, Russia (Far East), North Korea, South Korea, Japan (Shimane, Ishikawa, Nagano, Iwate, etc.) There is something. As the Korean-participating works, extract powder (Nagaoka Jitsugyo Co., Ltd.) etc. can be obtained commercially.

(iv) Maca Maca (also known as Peruvian ginseng), also called Andean ginseng, belongs to the Brassicaceae (scientific name: Lepidium meyanii) and is cultivated in the Andean highlands at an altitude of 3500-4500m. As the processed maca product, maca extract powder MACAXS-HC (TOWA CORPORATION) can be obtained commercially.

  The composition of the present invention uses the processed plant product. In the present invention, the processed product includes a pulverized product, a dried product, and a solvent extract thereof. As for these processed materials, what processed the rhizome part of each plant is preferred.

  The pulverized product of the plant is not particularly limited as long as the plant is pulverized by a pulverizer known in the art such as a jet mill.

  The dried product is not particularly limited as long as the plant is dried as it is. According to a conventionally known method such as sun drying, far-infrared irradiation, dryer (hot air drying, cold air drying, vacuum freeze drying) and the like. Can be obtained. The water content in the dried product is preferably 10% by weight or less, and more preferably 8% by weight or less. In the present invention, the form of the dried product is not limited, and any of a dried product of the plant itself and a pulverized product of the dried product may be used. In the case of a dry pulverized product, it can be obtained according to the same method as the pulverized product. Moreover, in this invention, what was obtained by drying after making the plant body (preferably especially rhizome part) used as a raw material into a dried material after fermentation treatment or an enzyme treatment can also be used.

  The composition of the present invention comprises (i) processed kanka and (ii) processed ashwaganda as essential components. These plants have been conventionally known to have an antioxidant action, but the present inventors have found for the first time that the antioxidant action is synergistically improved by using Kanka and Ashwagandha in combination. It is a thing.

  The composition of the present invention comprises the above (i) processed kanka and (ii) processed ashwagandha as essential components, and preferably contains (iii) a Korean participant or (iv) processed maca Includes both (iii) Gorye-participating artifacts and (iv) Maca processed products.

  In the composition of the present invention, the blend ratio of each processed product is (ii) 3 parts by weight or more, preferably 10 parts by weight or more, more preferably 30 parts by weight of the processed product of Ashwagandha to 100 parts by weight of the processed product of Kanka. It is about 3 to 500 parts by weight, preferably about 10 to 300 parts by weight, more preferably about 30 to 200 parts by weight. In addition, the said compounding quantity is shown with the value converted into the weight of a raw material dried material. In the present specification, the “raw material dry product” refers to a dry product of a raw material plant (preferably a rhizome part of each plant) used as a processed product.

  By containing each processed product at such a blending ratio, the composition of the present invention can exhibit further excellent antioxidant action.

  Moreover, when using an extract as a plant processed material used for the composition of this invention, an extract can be obtained with the following method.

  The method for obtaining the extract is, for example, the above plants (i) to (iv), or dried or pulverized products thereof, water, hot water, organic solvent (ethanol, methanol, isopropanol, propylene glycol, 1,3- Examples include alcohols such as butylene glycol; hydrous alcohols such as hydrous ethanol and hydrous methanol; ethers, hexane, benzene, chloroform, acetone, pentane, ethyl acetate, etc.) or a mixture thereof, followed by filtration. The extraction conditions are not particularly limited as long as they are generally applied to plant extraction. For example, 1 to 500 parts by weight, preferably 10 to 200 parts by weight of water with respect to 1 part by weight of the dried product. Or an organic solvent, and after stirring for about 1 to 300 minutes, preferably about 30 to 200 minutes with stirring at room temperature to about 100 ° C., preferably about 30 to 70 ° C., the solid content is removed by filtration. Can be mentioned.

  The extract thus obtained is a liquid product in which the soluble components of the plants (i) to (iv) are dissolved in the extraction solvent. This liquid extract may be concentrated as necessary. As a concentration method, a conventional method such as an evaporator can be used. Moreover, refining operations such as deodorization and decolorization can be added as long as the nutrition of each raw material is not lost.

  For example, in the case of obtaining an extract containing glycosides (for example, acteoside which is an active ingredient of kanka) as an active ingredient, it was obtained after solvent extraction of alcohol (including hydrous alcohol) or the like. The extract is concentrated, and the residue is suspended in water, washed with an organic solvent, passed through a column packed with an ion exchange resin, and eluted with an organic solvent (for example, Integrated Essential natural protein). Chemical chemistry (5th revised edition), Osamu Tanaka, Shigeo Nozoe, Norio Aimi, Masahiro Nagai (see Nankodo Co., Ltd.).

  For example, an excipient such as dextrin can be added to the obtained extract and dried according to a method known in the art such as spray drying. For convenience, an extract that can be obtained commercially from the above vendor can be used as a processed product of each plant. In the present invention, it is not particularly limited as long as the effects of the present invention are not impaired, but it is preferable to use an extract of a dried product of each raw material (preferably a dried product of a rhizome). Even when an extract is used as each processed product, the blending amount of the extract can be set based on the blending amount converted to the weight of the dried raw material.

  In addition to the above (i) Kanka processed product and (ii) Ashwagandha processed product, each compounding amount in the case of using (iii) Goryeo-participated product and / or (iv) Maca processed product together has the effect of the present invention. There is no particular limitation as long as it is not impaired. When using a Korean participated product or processed maca product, it is usually about 0.01 to 1000 parts by weight, preferably about 0.01 to 1000 parts by weight, based on 100 parts by weight of the processed Kanka product, preferably About 0.05 to 700 parts by weight, more preferably about 0.1 to 500 parts by weight; Maca processed product about 0.01 to 1000 parts by weight, preferably about 0.05 to 700 parts by weight, more preferably 0.1 About 500 parts by weight.

  Each component is contained in the following ratios in the dried plant raw material used in the present invention.

  Acteoside is known as an active ingredient of kanka, and is contained in the kanka about 0.1 to 1% by weight (per raw material dry weight).

  Withanolide is known as an active ingredient of Ashwagandha, and is contained in Ashwaganda by about 0.02 to 0.3% by weight (per raw material dry weight).

  Ginsenoside is known as an active ingredient of ginseng, and is contained in ginseng at about 0.1 to 1% by weight (per raw material dry weight).

  As an active ingredient of maca, benzylglucosinolate is known, and it is contained in maca at about 0.05 to 1% by weight (per raw material dry weight).

  In the present invention, by measuring the amount of each component in the composition, based on the content of the component specific to each plant, a value obtained by converting the blended amount of each processed product in the composition into the raw material dry weight Can be calculated as For example, when 10 μg of acteoside is contained in the composition, the content of acteoside in the kanka is 0.1 to 1% by weight, so the amount of processed kanka contained in the composition is converted to the dry weight of the raw material. Then, it can be calculated to be 1000 to 10,000 μg.

(v) Other components In addition to the components (i) to (iv) above, conventionally known colorants, preservatives, fragrances, flavors, coating agents, emulsifiers as long as they do not impair the effects of the present invention. Etc. can also be mix | blended.

  In addition to the components (i) to (iv) above, the composition of the present invention further contains other processed plant products, functional components, or medicinal components as long as the effects of the present invention are not impaired. can do. In addition, these components may be used alone or in combination with the above components (i) to (iv), or any combination of two or more of the above (i) to (iv) It can also be used in combination with ingredients.

  As other plants, similar to the components (i) to (iv) used in the present invention, red-crowned wrinkles, oysters, mulberries, Hypericum perforatum, camellia, Chinese garage, Yaba Santa, Rosehip, Asunaro, Plant extracts such as Acacia catechu, Itadori, Ichiakuso, Apricot, Keikanka, Hakukayumatou, Birch, Hawthorn, Achillea millefolium, Tarayo, Dokudami, Torumenchira, Bakumondou, Hiba, Grape, Mukuroji, Mokka, Ganoderma, Roman katsurame For example, grape seeds, hijiki, moroheiya, hijiki, cereals such as hamasge, beans, rice and wheat, herbs such as myrrh, basil, thyme, cacao extract, coffee extract, plum extract, Sanza Examples thereof include plant extracts such as shrimp extract and chlorella; soybean extract and black cohosh extract having female hormone-like action; rice germ extract having blood pressure lowering action and mental stability.

  In addition, phytic acid, black garlic, black vinegar, royal jelly, black pepper, sorghum, tonkat ant, pafia, muirapuama, tahibo, seven ginseng, red ginseng , Rahan fruit, propolis, litchi, bitter gourd, caiapo, yacon, mate tea, horsetail, reindeer horn, etc.

  Examples of functional components include humectants, antioxidants, hypoglycemic agents, anticholesterol agents, and immunostimulants.

  Here, examples of the humectant include hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, glucosamine, collagen, ceramide, and betaine.

  Antioxidants include, but are not limited to, dry yeast, glutathione, lipoic acid, quercetin, catechin, coenzyme Q10, enzodinol, proanthocyanidins, anthocyanidins, anthocyanins, carotenes, lycopene, flavonoids, resaveratrol, isoflavones, Examples include zinc, ginkgo biloba, moon peach leaf, hibiscus, and melatonin. Among these, dry yeast is preferable because it contains a relatively large amount of glutathione known as an antioxidant and various minerals.

  Antihyperglycemic agents include, but are not limited to, indigestible dextrin, guava leaf, wheat albumin, L-arabinose, bean extract, mulberry leaf, ginger, salacia, alpha-linolenic acid, macaque, barley, yellow aloe, dandelion, daidai daidai , Korean thistle, garlic, pearl barley, banaba, bilberry, black cohosh, makomo, kotarahim, and tanaka.

  Anticholesterol agents include, but are not limited to, soy protein, phospholipid-bound soy peptide, chitosan, plant sterol ester, plant sterol, plant stanol ester, indigestible dextrin, sodium alginate, psyllium seed coat, astaxanthin, inositol, coenzyme A, Calcium, Magnesium, Carnitine, Silk Protein, Taurine, Methionine, α-Linolenic Acid, Gua Gum, Chondroitin Sulfate, Achacharu, Alfalfa, Ginkgo, Psyllium, Barley, Oats, Olive, Gadju, Gymnema, Cats Claw, Cuco, Chlorella, Spirulina , Western hawthorn, soy saponin, chili, garlic, bilberry, safflower, yucca, ruffa, agaricus, red yeast rice.

  Examples of immunostimulants include agaricus, lactoferrin, cordyceps, arginine, tryptophan, valine, leucine, chitin, chitosan, aloe, kidachia aloe, echinacea, ogi, cat's claw, wolfberry, spirulina, pearl barley, safflower, maca, makomo, and ruma be able to.

  Examples of medicinal ingredients include vitamins, amino acids, peptides, proteins, minerals (such as iron, zinc, magnesium, and iodine), and fatty acids (such as EPA and DHA). Here, as vitamins, vitamins belonging to the vitamin A group (for example, retinal, retinol, retinoic acid, carotene, dehydroretinal, lycopene and pharmacologically acceptable salts thereof (for example, retinol acetate, retinol palmitate, etc.) Etc.), vitamins belonging to the group B (eg thiamine, thiamine disulfide, discetiamine, octothiamine, chicotiamine, bisbutiamine, bisbenchamine, prosultiamine, benfotiamine, fursultiamine, riboflavin, flavin adenine dinucleotide , Pyridoxine, pyridoxal, hydroxocobalamin, cyanocobalamin, methylcobalamin, deoxyadenocobalamin, folic acid, tetrahydrofolate, dihydrofolate, nicotinic acid, nicotinamide Nicotinic alcohol, pantothenic acid, panthenol, biotin, choline, inositol, pangamic acid and their pharmacologically acceptable salts thereof (eg thiamine hydrochloride, thiamine nitrate, dicetiamine hydrochloride, fursultiamine hydrochloride, riboflavin butyrate) Flavin adenine dinucleotide sodium, pyridoxine hydrochloride, pyridoxal phosphate phosphate, pyridoxal phosphate calcium, hydroxocobalamin hydrochloride, hydroxocobalamin acetate, calcium pantothenate, sodium pantothenate, etc.), vitamins belonging to the vitamin C group (ascorbic acid and its Derivatives, erythorbic acid and its derivatives and pharmacologically acceptable salts thereof (for example, sodium ascorbate, sodium erythorbate, etc.), vitamin Vitamins belonging to group D (for example, ergocalciferol, cholecalciferol, hydroxycholecalciferol, dihydroxycholecalciferol, dihydrotaxosterol and their pharmacologically acceptable salts), vitamin E group Vitamins belonging to (for example, tocopherol and derivatives thereof, ubiquinone derivatives and pharmacologically acceptable salts thereof (such as tocopherol acetate, tocopherol nicotinate, tocopherol succinate, tocopherol calcium succinate, etc.)), other vitamins (for example, Carnitine, ferulic acid, γ-oryzanol, orotic acid, rutin (vitamin P), eriocitrin, hesperidin and pharmacologically acceptable salts thereof (such as carnitine chloride). .

  As amino acids, leucine, isoleucine, valine, methionine, threonine, alanine, phenylalanine, tryptophan, lysine, glycine, asparagine, aspartic acid, serine, glutamine, glutamic acid, proline, tyrosine, cysteine, histidine, ornithine, hydroxyproline, hydroxy Examples thereof include lysine, glycylglycine, aminoethylsulfonic acid (taurine), cystine or pharmacologically acceptable salts thereof (for example, potassium aspartate, magnesium aspartate, cysteine hydrochloride, etc.). Preferably, branched chain amino acids such as valine, leucine and isoleucine, glutathione, cysteine, glutamic acid, glycine, serine, tryptophan, tyrosine, phenylalanine, histidine, methionine, threonine, lysine, cystine, arginine, alanine, aspartic acid, proline, amino Ethyl sulfonic acid, collagen and calcium.

(2) Food / beverage products and cosmetics The composition of the present invention is preferably prepared as an oral composition containing the above components. Examples of the oral composition of the present invention include health foods having an antioxidant action (nutrient functional foods, foods for specified health use, supplements, etc.), foods for the sick, and the like. When preparing the food / beverage product composition of the present invention as such a food / beverage product, the above composition may be used as an oral composition as it is, or in order to facilitate continuous intake, for example, a granule (Including dry syrup), capsules (soft capsules, hard capsules), tablets (including chewables, etc.), powders (powder), pills and other solid preparations, or liquids for internal use (liquids, suspensions) It is desirable to prepare it in the form of liquid preparations such as suspensions and syrups). Among them, capsules and tablets are preferable from the viewpoint of stability of each component and ease of ingestion. Is not to be done. The food / beverage product composition of the present invention in the form of capsules or tablets can use a known pharmaceutically acceptable carrier, and can be prepared by a conventional formulation method adopted in the fields of medicine and food (especially supplements). Can be applied. For example, a tablet can be prepared by adding and blending each component according to the formulation, crushing, granulating, drying, sizing and mixing, and tableting the resulting preparation mixture.

  Furthermore, additives for formulation, for example, excipients, lubricants, binders, disintegrating agents, fluidizing agents, dispersing agents, wetting agents, preservatives, thickeners, pH adjustments as necessary An agent, a coloring agent, a flavoring agent, a surfactant, a solubilizing agent, and the like can be blended, and a coating tablet can also be formed using a coating agent. It can also be used as a paste glue. Moreover, even if it is a case where it prepares in another form, what is necessary is just to follow the conventional method. Further, the composition of the present invention in the form of granules, powders, liquids, etc. is added to various foods and drinks such as beverages, confectionery, breads and soups; various pet foods such as dog foods and cat foods, etc. It can also be prepared as various foods and drinks. The method for producing these foods and drinks is not particularly limited as long as the effects of the present invention are not impaired, and may follow the methods used by those skilled in the art for each application.

  When the composition of the present invention is prepared in the form of food or drink, the intake of the composition of the present invention is 0.01 to 10,000 mg / day, preferably 0.05 in terms of processed kanka, based on an adult weighing 60 kg. ˜5000 mg / day, more preferably 0.1 to 1000 mg / day.

  Moreover, when preparing the composition of the present invention as an external composition such as a cosmetic, the above-mentioned composition may be used as it is as an external composition, and if necessary, a liquid, emulsion, cream, Various external preparations such as ointments can be used.

  The formulation can be applied by the usual formulation method adopted in the field of external preparation for skin including cosmetics. Furthermore, additives for formulation, for example, excipients, disintegrants, fluidizers, dispersants, wetting agents, preservatives, thickeners, thickeners, pH adjusters, coloring, if necessary Agents, flavoring agents, surfactants, solubilizers, pigments, fragrances and the like can be blended, and moisturizers, whitening agents, and other nutritional components can be blended.

  The total proportion of the components (i) to (iv) blended in the external composition of the present invention is 2 to 90% by weight, preferably 10 to 90% by weight, in terms of the weight of the dried raw material. It is desirable to adjust so that it may become 30 to 90 weight% preferably.

(3) Antioxidant Strength Enhancement Method By blending the processed ash tree with the Ashwagandha processed product, the antioxidant power inherent in kanka can be further enhanced. Therefore, the present invention also provides a method for enhancing antioxidant power.

  In the method for enhancing antioxidant power of the present invention, the blending ratio of each processed product is (ii) 3 parts by weight or more, preferably 10 parts by weight or more, of Ashwagandha processed product with respect to 100 parts by weight of processed Kanka. The amount is preferably 30 parts by weight or more, usually about 3 to 500 parts by weight, preferably about 10 to 300 parts by weight, and more preferably about 30 to 200 parts by weight. In addition, the said compounding quantity is shown by the value converted into the raw material dry weight.

  In addition to the above (i) Kanka processed product and (ii) Ashwagandha processed product, each compounding amount in the case of using (iii) Korean Participated Product and / or (iv) Maca Processed Product together has the effect of the present invention. Although it is not particularly limited as long as it is not damaged, it is usually about 0.01 to 1000 parts by weight, preferably 0.05 to 700 parts by weight, of Korean-participated products with respect to 100 parts by weight of the processed Kanka product in terms of the weight of the dried raw material. About 0.1 parts by weight, more preferably about 0.1 to 500 parts by weight; maca processed product about 0.01 to 1000 parts by weight, preferably about 0.05 to 700 parts by weight, more preferably about 0.1 to 500 parts by weight It is.

  Furthermore, this invention also provides the manufacturing method of the composition which has an antioxidant effect | action characterized by mix | blending Kanka processed material and Ashwagandha processed material. The amount of each processed product is as described in the method for enhancing antioxidant power.

  The composition of the present invention obtained as described above and a food and drink using the composition have an excellent antioxidant action (reactive oxygen removal action), and improve symptoms caused by an active oxygen adverse reaction, Effective for mitigation and prevention. The antioxidant activity of the composition and food / drink of the present invention is determined from the SOD activity measurement (cytochrome c method, NBT method, epinephrine method, nitrous acid method, etc.), electron spin resonance method, low light emission measurement method, and radical scavenging ability. (Evaluation based on reaction with phenoxyl radical, DPPH method, ORAC method, PAO method, ABTS radical method, free radical evaluation system, superoxide scavenging activity, active oxygen scavenging activity, diene bond amount, β-carotene Etc.) can be confirmed according to a known method.

  Adverse reactions caused by active oxygen include lifestyle-related diseases (diabetes, hyperlipidemia), arteriosclerosis, decreased liver function, inflammation, eye diseases (cataracts, retinopathy), brain disorders (Parkinson's disease, dementia), immunity The composition of the present invention is effective in alleviating (improving) and preventing these diseases and symptoms by exerting an antioxidant action (removal action of active oxygen). Furthermore, since the antioxidant action is said to be effective for beautifying skin, aging prevention, nourishing tonicity, improving blood flow, recovering from fatigue, preventing obesity, preventing cancer, etc., the composition of the present invention also exhibits the same effect. It is possible.

  Hereinafter, although an example and a formulation example are given and the present invention is explained, the present invention is not limited to these examples.

Test Example 1
Prepare the aqueous solution by dissolving Kanka, Ashwagandha, Ginseng and Maca extracts shown in Table 1 below in purified water at various concentrations, and use SOD Assay Kit-WST (Dojindo Laboratories). SOD-like activity was measured.

  Moreover, as shown in Table 1, the content of acteoside in kanka is 0.48% by weight (per dry matter weight), and the content of witanolide in ashwaganda is 0.16% by weight (per dry matter weight). there were.

  Based on the obtained results, an SOD curve was prepared and IC50 was calculated. Table 2 shows the IC50 of each component.

Test Example 2
A composition was prepared according to the formulation shown in Table 3 below, and SOD-like activity was measured in the same manner as in Test Example 1 above. From the results obtained, the values in the examples and the values in the reference examples were compared to calculate the rate of increase, and evaluated according to the following criteria. The results are shown in Table 3 and FIG. Each component is as described in Table 1 above.

  In the composition of Example 1-d, 5 μg of acteoside and 0.6 μg of withanolide were contained. This roughly correlated with the use of 1030 μg of Kanka and 370 μg of Ashwagandha for the dried raw material.

  As is clear from Table 3 and FIG. 1, it is recognized that superior antioxidative action is exhibited by using Kanka and Ashwagandha in combination with Kanka alone and Ashwaganda alone (from Table 1). It was. In addition to Kanka and Ashwagandha, it has been shown that a superior antioxidant effect is exhibited by using ginseng and / or maca in combination. Specifically, Kanka, Ashwagandha and Maca (Example 3) or Kanka, Ashwagandha, Ginseng and Maca compared to the combination of Kanka and Ashwaganda (Example 1), Kanka, Ashwagandha and Ginseng (Example 2). It was shown that the combination of (Example 4) exhibited further superior antioxidant activity.

Test Example 3
A composition was prepared according to the formulation shown in Table 4 below, and SOD-like activity was measured in the same manner as in Test Example 1 above. The results are shown in Table 4. Each component is as described in Table 1 above.

  In the table, N.D. indicates that the SOD-like activity was too weak to be detected.

  As is clear from Table 4, compared to Kanka alone (Reference Example 1) or Ashwagandha alone (Reference Examples 2 to 4), it was shown that when Kanka and Ashwaganda were used in combination, superior SOD-like activity was exhibited. (Examples 5-7). Specifically, SOD-like activity could be improved by combining with kanka even at a concentration of Ashwagandha that does not show SOD-like activity alone. In particular, it was shown that when Ashwagandha 35-70 μg / mL was blended with 100 μg / mL of kanka, it exhibited an extremely excellent antioxidant effect.

Formulation example (tablet)
As excipients, crystalline cellulose (60-150 mg), starch (40-100 mg), calcium stearate (15-25 mg), dextrin (5-10 mg) and fine silicon dioxide (2-8 mg) were used, The formulation described in 10 was prepared as a tablet according to conventional methods. Specifically, each component was blended according to the formulation, pulverized, granulated, dried, sized and mixed, and tableted according to a conventional method to prepare tablets (150 to 450 mg).
(Soft capsule)
Beeswax (40-100 mg), safflower oil (15-150 mg), gelatin (5-10 mg) and glycerin (2-8 mg) are used as excipients, and the formulations described in Tables 6-11 are used in conventional manner. Were prepared as soft capsules. Specifically, each component was blended according to the formulation, and the outer skin preparation, core liquid preparation, ball making and drying were performed according to a conventional method to prepare soft capsules (150 to 480 mg).
(Granule)
Dextrin (500-1500 mg) and xanthan gum (200-400 mg) were used as excipients, and the formulations listed in Tables 6-11 were prepared as granules according to conventional methods. Specifically, each component was blended according to the formulation, and mixed, granulated, dried and sized according to a conventional method to prepare granules (710 mg to 2130 mg).

It is the graph which plotted the value of Examples 1-4 of Table 3 on the SOD curve.

Claims (5)

An SOD activator comprising an Ashwagandha processed product and a Kanka processed product, wherein the Ashwagandha processed product is an aqueous alcoholic extract of Ashwagandha. The SOD activator according to claim 1, wherein the processed product of Ashwagandha is an extract obtained by extracting a dried product of Ashwagandha with water-containing ethanol. 3. The SOD activation according to claim 1, wherein the processed product of Ashwagandha is a powder obtained by extracting a dried root of Ashwagandha with water-containing ethanol to obtain an extract, and then drying an extract obtained from the extract. Agent. The SOD activator according to any one of claims 1 to 3, comprising 3 parts by weight or more of Ashwagandha processed product with respect to 100 parts by weight of processed Kanka. Furthermore, the SOD activator according to any one of claims 1 to 4, further comprising a Korean participant work and / or a processed maca product.

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