JP5283458B2 - Powder composition, food composition, cosmetic composition and pharmaceutical composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a powder composition well exhibiting preservation stability, together with redissolvability, and transparency after redissolution. <P>SOLUTION: The powder composition is water-soluble, and includes an oily component containing at least one kind of functional oily component; a phospholipid; and an excipient. In the powder composition, [the total amount of calcium and magnesium] derived from water contained for 1 kg of the powder composition, and represented by (formula 1): total amount of calcium and magnesium (mg/kg)=[amount of calcium (mg/kg)]&times;2.5+[amount of magnesium (mg/kg)]&times;4.1 is within the range of 10-700 mg/kg. <P>COPYRIGHT: (C)2010,JPO&amp;INPIT

Description

  The present invention relates to a powder composition, a food composition, a cosmetic composition, and a pharmaceutical composition.

  Conventionally, an oil component has been added to beverages, foods, cosmetics or pharmaceuticals. However, since the oily component is insoluble or hardly soluble in water, it is common to mix the oily component in an aqueous medium as a so-called emulsion by using some emulsifying means. Since the emulsion scatters light depending on its particle size, the emulsion and food and cosmetics to which the emulsion is added may become turbid, which may be undesirable in appearance, and the emulsion particle size until the light scattering becomes very small. It has been desired to reduce the size. In addition, emulsions are generally in a metastable state, the particle size becomes large during storage, and separation of an aqueous phase and an oil phase after long-term storage has been a big problem.

  On the other hand, with the recent boom in healthcare products, there are many products such as foods and cosmetics containing various functional oil components. Even in such products such as foods and cosmetics, when a functional oily component that is insoluble or sparingly soluble in water is contained, various problems such as deterioration of the material itself and destruction of the emulsified state during storage as described above can be caused. Has been found to have

As one method that can handle an oily component in a more stable state, a method of forming a powdered composition through a step of drying an emulsion has been proposed (for example, Patent Documents 1 and 2). Pulverization is a desirable method in terms of improving handling properties such as improvement in storage stability by removing moisture and reduction in transportation costs.
Powdered fats and oils are known as a general purpose powder composition, and examples of applications include bread products, frozen foods, Western confectionery, Japanese confectionery, fried products, and noodle products. As another example, flavors (fragrances) are known, and application examples include chewing gum, powdered beverages, powdered desserts, various toiletry products, fibers, and the like.
In addition, in order to impart storage stability, a method of forming powder particles by coating a physiologically active substance such as an oil component so as to form a calcium salt shell has also been attempted (for example, patents). Reference 3).
JP 2003-55688 A JP 2007-289064 A JP-A-7-328416

Thus, when it is set as the powder composition for a long-term storage, while a powder composition is excellent in storage stability and re-dissolvability, it is necessary to not lose transparency, even if it re-dissolves. The powder composition may easily absorb moisture, particularly under high humidity conditions, and may partially solidify (aggregate) after storage under such conditions. When such partial solidification occurs, the re-solubility tends to deteriorate. As mentioned above, powder compositions such as powdered fats and oils have been known, but products that satisfy all the storage stability, redissolvability and transparency after redissolution of such powder compositions are It has not been provided yet.
Therefore, an object of the present invention is to provide a powder formulation, a food composition, a cosmetic composition, and a pharmaceutical composition that can well exhibit both storage stability, re-dissolution property, and transparency after re-dissolution. .

In view of the above circumstances, the present inventors have conducted intensive research and found that the above problems can be solved, thereby completing the present invention.
That is, the present invention is achieved by the following means.

<1> A water-soluble powder composition containing an oily component containing at least one functional oily component, a phospholipid, and an excipient, the powder composition containing the oily component in the presence of phospholipid Under emulsification in an aqueous medium composed of water having a hardness represented by the following (formula 2) of 10 mg / L to 140 mg / L to obtain an emulsion composition, and drying the emulsion composition It is manufactured by a manufacturing method that includes:
The oily component comprises a carotenoid pigment, dl-α-tocopherol, dl-β-tocopherol, dl-γ-tocopherol, dl-δ-tocopherol, α-tocotrienol, β-tocotrienol, γ-tocotrienol, and δ-tocotrienol. At least one selected from the group,
The powder composition whose "calcium and magnesium total amount" derived from water contained per 1 kg of the powder composition represented by the following (Formula 1) is in the range of 10 mg / kg to 700 mg / kg .
(Formula 1) Calcium and magnesium total amount (mg / kg) = [calcium amount (mg / kg)] × 2.5 + [magnesium amount (mg / kg)] × 4.1
(Formula 2) Calcium and magnesium total amount (mg / L) = [calcium amount (mg / L)] × 2.5 + [magnesium amount (mg / L)] × 4.1
<2> The powder composition according to <1>, wherein the “total amount of calcium and magnesium” represented by (Formula 1) is in the range of 140 mg / kg to 500 mg / kg .
<3> The powder composition contains (a) an oil component containing at least one functional oil component, (b) a sucrose fatty acid ester and / or a polyglycerol fatty acid ester, and (c) a phospholipid, The powder according to <1> or <2>, which is a powder composition obtained by drying an emulsion composition in which the composition ratio of (b) and (c) is the same or a larger ratio of (b) Composition.
<4> The average particle diameter before Symbol powder composition 1g emulsion particle obtained when dissolved in water 300mL is in the range of less than or 1 nm 130 nm <1> ~ powder composition according to any one of <3> object.
< 5 > The powder composition according to any one of <1> to < 4 >, wherein the phospholipid has two fatty acid residues in one molecule.
< 6 > The powder composition according to any one of <1> to < 5 >, wherein the excipient is a monosaccharide or a polysaccharide.
<7> the excipient, Ru inulin der powder composition according to <6>.

<8> The is 3.0% or less than 0.5% water content of the powder composition <1> to powder composition according to any one of <7>.
< 9 > A method for producing a water-soluble powder composition comprising an oily component containing at least one functional oily component, a phospholipid, and an excipient, wherein the oily component is added in the presence of phospholipid, The emulsion represented by the following (Formula 2) is emulsified in an aqueous medium composed of water having a hardness of 10 mg / L to 140 mg / L to obtain an emulsion composition, the emulsion composition is dried, and the following ( the "calcium and magnesium total" represented from water containing per the powder composition 1kg formula 1) to obtain a powder composition in the range of 10 mg / kg ~700mg / kg, only contains the The oil component is carotenoid pigment, dl-α-tocopherol, dl-β-tocopherol, dl-γ-tocopherol, dl-δ-tocopherol, α-tocotrienol, β-tocotri Nord, method of producing a powder composition which is to γ- tocotrienol and at least one selected from the group consisting of δ- tocotrienol.
(Formula 1) Calcium and magnesium total amount (mg / kg) = [calcium amount (mg / kg)] × 2.5 + [magnesium amount (mg / kg)] × 4.1
(Formula 2) Calcium and magnesium total amount (mg / L) = [calcium amount (mg / L)] × 2.5 + [magnesium amount (mg / L)] × 4.1
< 10 > The emulsion composition contains (a) an oily component containing at least one functional oily component, (b) a sucrose fatty acid ester and / or a polyglycerol fatty acid ester, and (c) a phospholipid. < 9 > The method for producing a powder composition according to < 9 >, wherein the composition ratio of (b) and (c) is the same or the ratio of (b) is larger.
<1 1 > A food composition containing the powder composition according to any one of <1> to < 8 >.
<1 2 > A cosmetic composition containing the powder composition according to any one of <1> to < 8 >.
<1 3 > A pharmaceutical composition comprising the powder composition according to any one of <1> to < 8 >.

  ADVANTAGE OF THE INVENTION According to this invention, the powder composition, food composition, cosmetic composition, and pharmaceutical composition which can show favorable both storage stability, re-dissolution property, and transparency after re-dissolution can be provided.

The powder composition of the present invention is a water-soluble powder composition containing an oily component containing at least one functional oily component, a phospholipid, and an excipient, and is represented by the following (formula 1): The “total amount of calcium and magnesium” derived from water contained per kg of the powder composition is in the range of 10 to 700 mg / kg.
(Formula 1) Calcium and magnesium total amount (mg / kg) = [calcium amount (mg / kg)] × 2.5 + [magnesium amount (mg / kg)] × 4.1

The method for producing a powder composition in the present invention is a method for producing a water-soluble powder composition containing an oily component containing at least one functional oily component, a phospholipid, and an excipient, the oily component Is emulsified in an aqueous medium composed of water having a hardness represented by the following (formula 2) of 10 mg / L to 140 mg / L in the presence of phospholipid to obtain an emulsion composition, the emulsion composition Drying the product to obtain a powder composition in which the “total amount of calcium and magnesium” derived from 1 kg of the powder composition represented by the following (formula 1) is in the range of 10 to 700 mg / kg, including.
(Formula 1) Calcium and magnesium total amount (mg / kg) = [calcium amount (mg / kg)] × 2.5 + [magnesium amount (mg / kg)] × 4.1
(Formula 2) Calcium and magnesium total amount (mg / L) = [calcium amount (mg / L)] × 2.5 + [magnesium amount (mg / L)] × 4.1

In this powder composition, when the “calcium and magnesium total amount” derived from water contained in 1 kg of the powder composition is in the range of 10 to 700 mg / kg, storage stability, re-dissolution property, and transparency after re-dissolution are achieved. Both powders can be made into a good powder composition.
The reason why such an effect is obtained is not clear, but calcium and magnesium were formed around the functional oily component by the interaction of the salt with emulsifiers and excipients. It is considered that the storage stability of the functional oil component is improved to reinforce the matrix. Further, many calcium and magnesium salts generally have low water solubility, and may precipitate in some cases and cause color unevenness after re-dissolution. For example, if the amount is sufficient to form a shell, the appearance of the powder tends to be mottled. For this reason, by using calcium and magnesium in appropriate amounts in the present invention, the storage stability and re-dissolution are good, and the transparency after re-dissolution, in particular, there is no color unevenness and a transparent powder composition with a uniform color tone. Can be obtained.

  The emulsion composition according to the present invention contains calcium and magnesium derived from water used in the production process. The “calcium and magnesium total amount” derived from water is a range of 10 mg / kg to 700 mg / kg of the total amount of calcium and magnesium derived from water contained in 1 kg of the powder composition when the powder composition is formed. From the viewpoint of storage stability of the powder, it is preferably 140 mg / kg to 500 mg / kg, more preferably 200 mg / L to 500 mg / kg. These calcium and magnesium are usually contained in the form of inorganic salts such as carbonates and silicates.

  For the “total amount of calcium and magnesium” derived from water of the present invention, the value measured by the measuring method described in JIS K 0400-50-20 or the measuring method described in the text of JIS K 0400-51-10 and the appendix is applied. And can be calculated. Moreover, it is also possible to calculate from the result of measuring the used water according to the method for producing the emulsion composition.

In general, the amount of calcium and magnesium in water is described using a value called hardness. The “hardness” of water is the amount of calcium and magnesium converted to the amount of calcium carbonate (CaCO ₃ ) and is expressed in mg / L or ppm. When this is expressed by a calculation formula, it can be generally calculated using the following simple formula (Formula 2), and the hardness in the present invention is according to this Formula (2).
(Formula 2) Hardness [mg / L] = (calcium amount [mg / L] × 2.5) + (magnesium amount [mg / L] × 4.1)

  Water is classified into hard water and soft water according to the hardness, and the hardness is determined by the amount of calcium ions and magnesium ions dissolved in the water. And water containing a lot of hardness is called "hard water". According to drinking water quality guidelines of the World Health Organization (WHO), soft water (hardness 0 to less than 60 mg / L), moderate soft water (hardness 60 to less than 120 mg / L), hard water (hardness 120 to less than 180 mg / L) And very hard water (hardness 180 mg / L or more).

The preferred hardness range of water used in the present invention is a hardness of 10 mg / L or more and 140 mg / L or less, preferably a hardness of 10 mg / L or more and 120 mg / L or less, from the viewpoint of storage stability of the finished powder composition. Water having a hardness of 10 mg / L or more and 80 mg / L or less is more preferable. Such water can be tap water, ground water (for example, mineral water) or the like, but generally water with hygiene management suitable for drinking is preferred. In addition, since water obtained through a pure water pure treatment device or the like in order to obtain chemically high quality water generally has a hardness of less than 10 mg / L, it is appropriately selected from organic and inorganic salts of calcium and magnesium. May be used to adjust the water used to form the emulsion composition in the present invention.
Examples of organic salts or inorganic salts that can be added to adjust the amount of calcium and magnesium include, for example, calcium carbonate, magnesium carbonate, calcium silicate, magnesium silicate, and the like. One or more types can be selected from the inside.

The method for producing an emulsion composition in the present invention is not particularly limited. For example, I) a step of obtaining a water phase by dissolving a surfactant in an aqueous medium (water or the like) composed of water having the hardness described above, II) A step of mixing and dissolving the oily component and phospholipid to obtain an oil phase, and III) A step of mixing an aqueous phase and an oil phase with stirring, emulsifying and dispersing to obtain an emulsion composition. The method is preferred.
Hereinafter, each component used for manufacture of an emulsion composition is demonstrated.

(A) Oily component Functional oily component The functional oily component used in the present invention represents an oily component that exhibits useful effects when used in foods, cosmetics, and pharmaceuticals. The oil-based component in the present invention refers to oil-soluble components such as oil that is liquid at normal temperature and oils and fats that are semi-solid or solid at normal temperature. In terms of chemical structure, there are oils and fats, hydrocarbons, waxes, esters, fatty acids, higher alcohols, polymers, oil-soluble pigments, oil-soluble proteins and the like. In addition, various plant-derived oils and animal-derived oils, which are mixtures thereof, are included, but are not particularly limited thereto.
In addition, from the functional aspect of the functional oil component, ultraviolet absorbers, antioxidants, anti-inflammatory agents, moisturizers, hair protecting agents, dispersants, solvents, whitening agents, anti-staining agents, cell activators, emollients, Examples include, but are not limited to, keratolytic agents, antistatic agents, vitamins, metabolic syndrome improving agents, antihypertensive agents, sedatives and the like.

Examples of preferable functional oily components used in the present invention are preferably at least one selected from the group consisting of carotenoids (carotenoid pigments), fat-soluble vitamins, and fat-soluble vitamin-like substances, which will be described later. Carotenoids, fat-soluble vitamins, fat-soluble vitamin-like substances (ubiquinones, ω-3 fats and oils (oils and fats containing EPA, DHA, linolenic acid, etc.)) and the like.
Many of these preferred functional oily components exhibit vivid colors. For example, according to the present invention, a powder composition containing a functional oily component having such a bright color is preferable because it has no color unevenness and looks uniform throughout.

  In the present invention, among these functional oil components, carotenoids, fat-soluble vitamins, ubiquinones, ω-3 oils and fats, especially carotenoids (also referred to as carotenoids) that are oil-soluble functional pigments are applied to the present invention. When dispersed in water, a powder composition having a remarkable effect of high transparency and excellent storage stability can be obtained.

Carotenoids Carotenoids in the present invention can preferably include carotenoids containing natural pigments, which are yellow to red terpenoid pigments, including those of plants, algae, and bacteria. .
Moreover, it is not limited to the thing of natural origin, Any thing will be contained in the carotenoid in this invention if it can be obtained in accordance with a conventional method. For example, many of the carotenoids of carotenoids described below are also produced by synthesis, and most of commercially available β-carotene is produced by synthesis.

  Examples of such carotenoids include hydrocarbons (carotenes) and their oxidized alcohol derivatives (xanthophylls). Among them, actinioerythrol, astaxanthin, bixin, canthaxanthin, capsanthin, capsorbin, β- Apo-8'-carotenal (apocarotenal), β-12'-apo-carotenal, α-carotene, β-carotene, “carotene” (mixture of α- and β-carotenes), γ-carotene, β-cryptoxanthin , Lutein, lycopene, violaxanthin, zeaxanthin, and esters of those containing hydroxyl or carboxyl can be preferably mentioned.

Many of the carotenoids occur naturally in the form of cis and trans isomers, but synthetics are often cis-trans mixtures.
Carotenoids can generally be extracted from plant materials. These carotenoids have a variety of functions, for example, lutein extracted from marigold petals is widely used as an ingredient in poultry food and colors poultry skin and fat and eggs produced by poultry There is a function.

  The carotenoids used in the present invention are preferably oily at normal temperature from the viewpoint of handling, and particularly preferably have an antioxidant effect, an anti-inflammatory effect, a skin aging preventive effect, a whitening effect, etc., yellow To at least one selected from derivatives such as esters of astaxanthin and astaxanthin (hereinafter sometimes collectively referred to as “astaxanthins”).

Astaxanthin is a red pigment with absorption maxima at 476 nm (ethanol) and 468 nm (hexane) and belongs to a kind of carotenoid xanthophyll (Davies, BH: In “Chemistry and Biochemistry of Plant Pigments”, TW Goodwin ed., 2nd. ed., 38-165, Academic Press, NY, 1976.). The chemical structure of astaxanthin is 3,3′-dihydroxy-β, β-carotene- ₄ , 4′-dione (C ₄₀ H ₅₂ O ₄ , molecular weight 596.82).

  Astaxanthin has a 3S, 3S′-form, 3S, 3R′-form (meso-form), 3R, 3R ′-, due to the configuration of the 3 (3 ′)-positioned hydroxyl groups of the ring structure present at both ends of the molecule. There are three isomers of the body. In addition, there are cis- and trans- isomers of conjugated double bonds at the center of the molecule. For example, all cis-, 9-cis and 13-cis isomers.

  The hydroxyl group at the 3 (3 ')-position can form an ester with a fatty acid. Astaxanthin obtained from krill is a diester (Yamaguchi, K., Miki, W., Toriu, N., Kondo, Y., Murakami, M., Konosu, S., Satake, M., Fujita). , T .: The composition of carotenoid pigments in the antarctic krill Euphausia superba, Bull. Jap. Sos. Sci. Fish., 1983, 49, p.1411-1415. The product obtained from Pluvialis is 3S, 3S'-, which contains many monoesters with one fatty acid (Renstrom, B., Liaaen-Jensen, S .: Fatty acids of some esterified carotenols, Comp. Biochem Physiol. B, Comp. Biochem., 1981, 69, p. 625-627.).

  Astaxanthin obtained from Phaffia Rhodozyma is 3R, 3R′-form (Andrewes, AG, Starr, MP: (3R, 3′R) -Asttaxanthin from the yeast Phaffa rhodozyma, Phytochem., 1976, 15, p.1009. -1011.) And has the opposite structure to the 3S, 3S′-form normally found in nature. It also exists in free form that does not form esters with fatty acids (Andrewes, AG, Phaffia, HJ, Starr, MP: Carotenids of Phaffia rhodozyma, a red pigmented fermenting yeast, Phytochem., 1976, 15, p. .1003-1007.)

  Astaxanthin and its ester are R.I. Kuhn et al. First isolated from lobster (Astacus gammarus L.) and disclosed its putative structure (Kuhn, R., Soerensen, NA: The coloring matters of the lobster (Astacus gammarus L.), Z. Angew. Chem. , 1938, 51, p.465-466.). Since then, it has been clarified that astaxanthin is widely distributed in nature and usually exists as an astaxanthin fatty acid ester, and also exists as an astaxanthin protein (oborbin, cluster cyanine) bound to proteins in crustaceans (Cheesman , DF: Ovorubin, a chromoprotein from the eggs of the gastropod mollusc Pomacea canaliculata, Proc. Roy. Soc. B, 1958, 149, p.571-587.).

The astaxanthin and its ester (astaxanthins) may be contained in the emulsion composition according to the present invention as an astaxanthin-containing oil separated and extracted from a natural product containing astaxanthin and / or its ester. Examples of such astaxanthin-containing oils include red yeast paffia, green algae hematococcus, marine bacteria, and the like, and extracts from the cultures, extracts from Antarctic krill, and the like.
It is known that hematococcus algae extract (haematococcus algae-derived pigment) differs from krill-derived pigment and synthesized astaxanthin in terms of the main component of fatty acid ester (monoester, diester, etc.). (Http://www.astaxanthin.co.jp/chemical/basic.htm)

  Astaxanthins that can be used in the present invention may be the above-mentioned extract, or a product obtained by appropriately purifying the extract as necessary, or a synthetic product. As the astaxanthins, those extracted from Haematococcus alga (also referred to as Haematococcus alga extract) are particularly preferred from the viewpoint of quality and productivity.

  Specific examples of the haematococcus alga extract that can be used in the present invention include Haematococcus pluviaris, Haematococcus lacustris, Examples thereof include Haematococcus droebakensis, Haematococcus zimbabiensis, and the like.

  The method for culturing Haematococcus algae that can be used in the present invention can employ various methods disclosed in JP-A-8-103288 and the like, and is not particularly limited. What is necessary is just to change the form to a cyst cell.

The Haematococcus alga extract that can be used in the present invention is prepared by using the above-mentioned raw materials, if necessary, by crushing the cell wall by a method disclosed in, for example, JP-A-5-68585, etc., and adding acetone, ether, chloroform, and alcohol. It can be obtained by adding an organic solvent such as (ethanol, methanol, etc.) or an extraction solvent such as supercritical carbon dioxide.
In the present invention, commercially available Haematococcus alga extract can be used. For example, ASTOTS-S, -2.5 O, -5 O, and -10 manufactured by Takeda Paper Instruments Co., Ltd. O, etc., Asteryl Oil 50F, 5F, etc. manufactured by Fuji Chemical Industry Co., Ltd., BioAstin SCE7 manufactured by Toyo Enzyme Chemical Co., Ltd., and the like.

The content of astaxanthin in the Haematococcus alga extract that can be used in the present invention is preferably 0.001 to 50 mass%, more preferably 0.01 to 25 mass%.
The Haematococcus alga extract that can be used in the present invention contains astaxanthin or an ester thereof as the pure pigment, as in the pigment described in JP-A-2-49091. % Or more, preferably 75 mol% or more, more preferably 90% mol or more.
Further details are described in “chemistry of astaxanthin”, 2005, Internet <URL: http://www.astaxanthin.co.jp/chemical/basic.htm>.

  These astaxanthins are more preferably extracted with supercritical carbon dioxide in terms of odor when powdered.

Ubiquinones Examples of ubiquinones include coenzyme Qs such as coenzyme Q10. Coenzyme Q10 was approved and sold in Japan in 1974 as an ethical drug for metabolic cardiotonic drugs. Since then, it has been treated as a medicine including OTC. On the other hand, overseas (mainly Europe and America) has been growing in demand for health food materials with high effectiveness and safety for the past 10 years. And in Japan, in 2001, the Ministry of Health, Labor and Welfare's Director General of Pharmacy “Revision of Standards on the Scope of Drugs” (Pharmaceutical Development No. 243) stated that Coenzyme Q10 is “essential as an ingredient that is recognized as a food unless it is intended to have a medicinal effect. (Raw materials) "list has been released and the regulation has been relaxed so that it can be handled as food. In Japan, attention has been paid to the various functions of this food material, and many general foods (so-called health foods) containing coenzyme Q10 are being commercialized.

  In order to take advantage of the function of coenzyme Q10, it is important to make this material, which is a fat-soluble substance, water-soluble. The purpose of water solubilization is that the fat-soluble physical property is considered to be low in vivo absorption if it is not ingested with meals. Is to ensure that These may be used alone or in combination.

Fat-soluble vitamins Examples of the fat-soluble vitamins in the present invention include fat-soluble vitamin Es, retinoids, vitamin Ds, oil-solubilized derivatives of ascorbic acid and erythorbic acid. It is preferable that the fat-soluble vitamin E is highly usable as a radical scavenger.
Fat-soluble vitamin Es include, but are not limited to, tocopherol and tocotrienol and their derivatives, such as dl-α-tocopherol, dl-β-tocopherol, dl-γ-tocopherol, dl-δ-tocopherol, acetic acid. dl-α-tocopherol, nicotinic acid-dl-α-tocopherol, linoleic acid-dl-α-tocopherol, tocopherols and their derivatives such as dl-α-tocopherol succinate, α-tocotrienol, β-tocotrienol, γ-tocotrienol, and δ-tocotrienol. These may be used singly or in combination, but are preferably used in the form of a mixture, and those in the form of a mixture include those called extracted tocopherol, mixed tocopherol and the like.

Examples of retinoids include retinol, 3-hydroretinol, retinal, 3-hydroretinal, retinoic acid, 3-dehydroretinoic acid, vitamin A acetate and other vitamin A; α, β, γ-carotene, β-cryptoxanthin, Examples thereof include carotenoids such as echinenone and provitamins A such as xanthophyll. Examples of vitamin Ds include vitamin Ds such as vitamins D _{2 to} D ₇ .
Examples of other fat-soluble vitamins substances, esters such as nicotinic acid vitamin E; may be mentioned vitamin K ₁ or vitamin K, such as K _3.
Examples of oil-solubilized derivatives such as ascorbic acid and erythorbic acid include stearic acid L-ascorbyl ester, tetraisopalmitic acid L-ascorbyl ester, palmitic acid L-ascorbyl ester, palmitic acid erythorbyl ester, tetraisopalmitic acid erythorbyl ester, Examples include fatty acid esters of vitamin C such as ascorbyl dioleate, and fatty acid esters of vitamin B ₆ such as pyridoxine dipalmitate, pyridoxine tripalmitate, pyridoxine dilaurate, and pyridoxine dioctanoate. Of these, oil-solubilized derivatives of ascorbic acid and erythorbic acid can also be used as radical scavengers.

ω-3 oils and fats Examples of ω-3 oils and fats include linolenic acid, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and fish oils containing these.

In addition to the above, compounds that can be used as oil components include liquid oils (fatty oils) and solid oils (fats) at room temperature.
Examples of the liquid oil include olive oil, camellia oil, macadamia nut oil, castor oil, avocado oil, evening primrose oil, turtle oil, corn oil, mink oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, and sasanca Oil, flaxseed oil, safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, cinnagari oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin, glycerin trioctanoate, Examples include glycerin triisopalmitate, salad oil, safflower oil (safflower oil), palm oil, coconut oil, peanut oil, almond oil, hazelnut oil, walnut oil, grape seed oil, squalene, and squalane.
Moreover, as the solid fats and oils, beef tallow, hardened beef tallow, beef leg fat, beef bone fat, mink oil, egg yolk oil, pork tallow, horse fat, sheep fat, hardened oil, cocoa butter, palm oil, hardened palm oil, Palm oil, palm hardened oil, owl, owl kernel oil, hardened castor oil and the like can be mentioned.

  In addition, as other oily components, usually UV absorbers, antioxidants, anti-inflammatory agents, moisturizers, hair protecting agents, dispersants, solvents, whitening agents, anti-staining agents, cell activators, emollients, keratolytic agents Other ingredients used as antistatic agents, vitamins, metabolic syndrome improving agents, antihypertensives, sedatives, etc. can also be used, such as liquid paraffin, paraffin, petrolatum, ceresin, microcrystalline wax, etc. Hydrocarbons, carnauba wax, candelilla wax, jojoba oil, beeswax, lanolin and other waxes, isopropyl myristate, 2-octyldodecyl myristate, cetyl 2-ethylhexanoate, diisostearyl malate, palmitic acid , Fats such as stearic acid, isostearic acid, linoleic acid, arachidonic acid , Cetyl alcohol, stearyl alcohol, isostearyl alcohol, higher alcohols such as 2-octyldodecanol, silicone oils such as methylpolysiloxane and methylphenylpolysiloxane, other polymers, oil-soluble pigments, oil-soluble proteins And so on. In addition, various plant-derived oils and animal-derived oils that are mixtures thereof are also included.

  In order to further improve the dispersibility in water, the oil component is preferably used in combination of two or more. As the oil component that can be used in combination for this purpose, DHA, squalene, and squalane are preferable, and squalene is particularly preferable. In particular, in the case of oily components that are solid at room temperature, such as Coenzyme Q10, it is particularly preferable to use in combination with DHA, squalene, squalane and the like.

The emulsion composition according to the present invention may contain a radical scavenger.
The radical scavenger is an additive that suppresses the generation of radicals and also captures the generated radicals as quickly as possible and plays a role in breaking the chain reaction (Source: “Oil Chemistry Handbook 4th Edition”, Japan Oil Chemists' Society). Ed. 2001).

As a direct method for confirming the function as the radical scavenger, there is known a method in which the state of trapping radicals by mixing with a reagent is measured by a spectrophotometer or an ESR (electron spin resonance apparatus). In these methods, DPPH (1,1-diphenyl-2-picrylhydrazyl) or galvinoxyl radical is used as a reagent.
In the present invention, the time required to raise the peroxide value (POV value) of fats and oils to 60 meq / kg using the autoxidation reaction of fats and oils under the following experimental conditions is more than twice that of the blank. Certain compounds are defined as “radical scavengers”. The peroxide value (POV value) of fats and oils is measured by a conventional method.

<Conditions>
Oil and fat: Olive oil Sample addition amount: 0.1% by mass based on oil and fat
Test method: The sample was heated at 190 ° C., the POV value was measured by a conventional method over time, and the time for 60 meq / kg was calculated.

  The radical scavenger in the present invention is preferably a radical scavenger in which the time required to reach the POV value of 60 meq / kg is 5 times or more that of the blank from the viewpoint of the stability against emulsion oxidation.

  Compounds that can be used as radical scavengers in the present invention are described in “Theory and Practice of Antioxidants” (Enomoto, Sanshobo 1984) and “Antioxidants Handbook” (Saruwatari, Nishino, Tabata, Taiseisha 1976). Of the various antioxidants described, it is sufficient that it functions as a radical scavenger. Specifically, compounds having phenolic OH, amine compounds such as phenylenediamine, and oils of ascorbic acid and erythorbic acid Examples include solubilized derivatives.

The content of the radical scavenger in the emulsion composition of the present invention is generally 0.001 to 5.0 mass%, preferably 0.01 to 3.0 mass%, more preferably 0.1 to 0.1 mass%. 2.0% by mass.
Preferred radical scavengers (antioxidants) are exemplified below, but the present invention is not limited to these.
The emulsion composition according to the present invention comprises a compound group (I) ascorbic acid or erythorbic acid or a salt thereof, or a compound group comprising an ascorbic acid derivative or an erythorbic acid derivative or a salt thereof as a radical scavenger, (II) a compound comprising a polyphenol It is preferable to contain at least two compounds selected from the group.

(I) Ascorbic acid or erythorbic acid or salts thereof Ascorbic acid or ascorbic acid derivatives or salts thereof include L-ascorbic acid, L-ascorbic acid Na, L-ascorbic acid K, L-ascorbic acid Ca, and L-ascorbic acid phosphorus Acid ester, magnesium salt of L-ascorbic acid phosphate, L-ascorbic acid sulfate, L-ascorbic acid sulfate disodium salt, L-ascorbic acid stearate, L-ascorbic acid 2-glucoside, L-ascorbyl Acid palmitate ester, tetraisopalmitate L-ascorbyl and the like can be mentioned. Among these, L-ascorbic acid, L-ascorbic acid Na, L-ascorbic acid stearate, L-ascorbic acid 2-glucoside, L-ascorbyl palmitate, magnesium salt of L-ascorbic acid phosphate, L-ascorbic acid sulfate disodium salt and L-ascorbyl tetraisopalmitate are particularly preferred.

  As erythorbic acid or erythorbic acid derivatives or salts thereof, erythorbic acid, erythorbic acid Na, erythorbic acid K, erythorbic acid Ca, erythorbic acid phosphate ester, erythorbic acid sulfate ester, erythorbic acid palmitic acid ester, tetraisopalmitic acid erythorbyl, etc. Is mentioned. Of these, erythorbic acid and erythorbic acid Na are particularly preferred.

  As the radical scavenger belonging to the compound group (I) used in the present invention, commercially available ones can be appropriately used. For example, L-ascorbic acid (Takeda Pharmaceutical, Fuso Chemical, BASF Japan, Daiichi Pharmaceutical, etc.), L-ascorbic acid Na (Takeda Pharmaceutical, Fuso Chemical, BASF Japan, Daiichi Pharmaceutical, etc.), Ascorbic acid 2-glucoside (Product name: AA-2G: Hayashibara Biochemical Research Institute), Mg as L-ascorbate phosphate (Product name: Ascorbic acid PM “SDK” (Showa Denko), Product name: NIKKOL VC-PMG (Nikko Chemicals), Product name: Seamate (Takeda) Pharmaceutical industry)), ascorbyl palmitate (DSM Nutrition Japan, Kongo Pharmaceutical, Merck, etc.).

(II) Compound group consisting of polyphenols As compound group consisting of polyphenols, flavonoids (catechin, anthocyanin, flavone, isoflavone, flavan, flavanone, rutin), phenolic acids (chlorogenic acid, ellagic acid, gallic acid, propyl gallate) ), Lignans, curcumins, coumarins and the like. Moreover, since these compounds are contained in a large amount in the following natural product-derived extracts, they can be used in the form of extracts.

  For example, licorice extract, cucumber extract, caquette extract, gentian (gentian) extract, Gentian extract, cholesterol and its derivatives, hawthorn extract, peonies extract, ginkgo biloba extract, scallop (Ogon) extract, carrot Extract, Maika (Maika, Hamanasu) extract, Sunpens (Kawara-Ketsumei) extract, Tormentilla extract, Parsley extract, Button (buttonpi) extract, Mokka (bokeh) extract, Melissa extract, Yashajitsu (Yasha) extract , Yukinoshita extract, Rosemary (mannenrou) extract, lettuce extract, tea extract (Oolong tea, black tea, green tea, etc.), microbial fermentation metabolites, Rakan fruit extract, etc. (in parentheses are plant aliases) , Herbal medicine name etc. were described.) Among these polyphenols, particularly preferred are catechin, rosemary extract, glucosyl rutin, ellagic acid, and gallic acid.

  As the radical scavenger belonging to the compound group (II) used in the present invention, commercially available ones can be appropriately used. For example, ellagic acid (Wako Pure Chemicals, etc.), rosemary extract (trade names RM-21A, RM-21E: Mitsubishi Chemical Foods, etc.), catechin (trade names Sancatol W-5, No. 1: Taiyo Kagaku, etc.) , Na gallate (trade name: Sancatol: Taiyo Kagaku, etc.), rutin, glucosylrutin, enzymatically-decomposed rutin (trade names: rutin K-2, P-10: Kiriya Chemical, trade name: αG rutin: Hayashibara Biochemical Laboratory, etc. ) And the like.

The content of the (a) oil component in the powder composition according to the present invention is preferably 1 to 50% by mass, more preferably 5 to 35% by mass, and still more preferably 10 to 30% by mass.
If the content of the oil component is 1% by mass or more, the amount is sufficient to obtain the effect of the oil component without using a large amount. On the other hand, if the content is 50% by mass or less, the oil component is added to the powder surface. This is preferable because it effectively suppresses oozing due to storage aging and improves handling.
In the present invention, when another oil component is used in combination with the above functional oil component, the functional oil component is preferably 10% by mass to 99% by mass, more preferably 50% by mass with respect to the entire oil component. It can be used at ˜99% by mass.

(B) Sucrose fatty acid ester and / or polyglycerol fatty acid ester The powder composition of the present invention contains sucrose fatty acid ester and / or polyglycerol fatty acid ester as component (b).
All of these act as a surfactant and can make the average particle diameter of the emulsion particles smaller when the emulsion composition is obtained.

The sucrose fatty acid ester used in the present invention preferably has a fatty acid having 12 or more carbon atoms, more preferably 12 to 20 from the viewpoint of surface activity. By setting it to 12 or more carbon atoms, it may be possible to make emulsion particles having a smaller average particle diameter.
Sucrose fatty acid esters include sucrose dioleate, sucrose distearate, sucrose dipalmitate, sucrose dimyristate, sucrose dilaurate, sucrose monooleate, sucrose monostearate Acid ester, sucrose monopalmitic acid ester, sucrose monomyristic acid ester, sucrose monolauric acid ester, etc., among which sucrose monoester is preferred, and in particular, sucrose monolauric acid ester, sucrose monooleic acid Esters are more preferred. In the present invention, these sucrose fatty acid esters can be used alone or in combination.

  Examples of commercially available products include Ryoto Sugar Esters S-070, S-170, S-270, S-370, S-370F, S-570, S-770, and S-970 manufactured by Mitsubishi Chemical Foods Corporation. , S-1170, S-1170F, S-1570, S-1670, P-070, P-170, P-1570, P-1670, M-1695, O-170, O-1570, OWA-1570, L -195, L-595, L-1695, LWA-1570, B-370, B-370F, ER-190, ER-290, POS-135, Monoester P, manufactured by Daiichi Kogyo Seiyaku Co., Ltd. DK ester SS, F160, F140, F110, F90, F70, F50, F-A50, F-20W, F-10, F-A10E, Cosmelike B-30, S-10, S-5 , S-70, S-110, S-160, S-190, SA-10, SA-50, P-10, P-160, M-160, L-10, L-50, L-160, L -150A, L-160A, R-10, R-20, O-10, O-150 and the like.

The polyglycerol fatty acid ester used in the present invention has an average degree of polymerization of 2 or more, preferably 6 to 15, more preferably 8 to 10 and a fatty acid having 8 to 18 carbon atoms such as caprylic acid and capric acid. And esters with lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, and linoleic acid. Preferred examples of polyglycerol fatty acid esters include hexaglycerol monooleate, hexaglycerol monostearate, hexaglycerol monopalmitate, hexaglycerol monomyristate, hexaglycerol monolaurate, decaglycerol monooleate , Decaglycerin monostearic acid ester, decaglycerin monopalmitic acid ester, decaglycerin monomyristic acid ester, decaglycerin monolauric acid ester and the like.
Among these, more preferably, decaglycerol monooleate (HLB = 12), decaglycerol monostearate (HLB = 12), decaglycerol monopalmitate (HLB = 13), decaglycerol monomyristate (HLB = 14), decaglycerin monolaurate (HLB = 16), and the like.
These polyglycerin fatty acid esters can be used alone or in combination.

  Examples of commercially available products include Nikko Chemicals, Inc., NIKKOL DGMS, NIKKOL DGMO-CV, NIKKOL DGMO-90V, NIKKOL DGDO, NIKKOL DGMIS, NIKKOL DGTI, NIKKOL DGTI, NIKKOL DGTI Tetraglyn 3-S, NIKKOL Tetraglyn 5-S, NIKKOL Tetraglyn 5-O, NIKKOL Hexaglyn 1-L, NIKKOL Hexaglyn 1-M, NIKKOL Hexaglyn 1-SV, NIKKOL Hexaglyn 1-O, NIKKOL Hexaglyn 3-S, NIKKOL Hexaglyn 4 -B, NIKKOL Hex aglyn 5-S, NIKKOL Hexaglyn 5-O, NIKKOL Hexaglyn PR-15, NIKKOL Decaglyn 1-L, NIKKOL Decaglyn 1-M, NIKKOL Decaglyn 1-SV, NIKKOL Decaglyn 1-50SV, NIKKOL Decaglyn 1-ISV, NIKKOL Decaglyn 1 -O, NIKKOL Decaglyn 1-OV, NIKKOL Decaglyn 1-LN, NIKKOL Decaglyn 2-SV, NIKKOL Decaglyn 2-ISV, NIKKOL Decaglyn 3-SV, NIKKOL Decaglyn 3-OV, NIKKOL Decaglyn 5-SV, NIKKOL Decaglyn 5- S, NIKKOL Decaglyn 5-IS, NIKKOL Decaglyn 5-OV, NIKKOL Decaglyn 5-O-R, NIKKOL Decaglyn 7-S, NIKKOL Decaglyn 7-O, NIKKOL Decaglyn 10-SV, NIKKOL Decaglyn 10-IS, NIKKOL Decaglyn 10- OV, NIKKOL Decaglyn 10-MAC, NIKKOL Decaglyn PR-20, Ryoto Polyglycerester L-7D, L-10D, M-10D, P-8D, SWA-10D, SWA-15D, manufactured by Mitsubishi Chemical Foods, Inc. SWA-20D, S-24D, S-28D, O-15D, O-50D, B-70D, B-100D, ER-60D, LOP-120 P, DS13W, DS3, HS11, HS9, TS4, TS2, DL15, DO13, Taiyo Chemical Co., Ltd. Sunsoft Q-17UL, Sunsoft Q-14S, Sunsoft A-141C, Riken Vitamin Co., Ltd. Examples include Poem DO-100 and Poem J-0021.

  The component (b) is preferably 1% by mass to 50% by mass, more preferably 5% by mass to 50% by mass with respect to the total powder composition from the viewpoint of emulsion stability and storage stability after re-dissolution. These components can be contained, and can be appropriately adjusted within this range depending on the intended use of the powder composition. In particular, from the viewpoint of absorbability in the body, the ratio of the component (b) to the total powder composition is more preferably as high as possible within the above range. On the other hand, from the viewpoint of refining the emulsion particles during re-dissolution, the component (b) The lower the ratio to the total powder, the more preferable. For example, the component (b) can be preferably 45% by mass or less, more preferably 40% by mass or less, with respect to the powder composition, from the viewpoint of atomization at the time of re-dissolution.

  The powder composition in this invention should just contain any one of these sucrose fatty acid ester and polyglycerol fatty acid ester, and it is preferable to use together from a viewpoint which improves the storage stability of powder more. When these sucrose fatty acid esters and polyglyceric acid esters are used in combination as these components (b), there is no particular limitation, but sucrose fatty acid esters and polyglycerin fatty acid esters can be used from the viewpoint of improving the storage stability of the powder. The mass ratio is preferably 10:90 to 90:10, and more preferably 20:80 to 80:20.

  As these sucrose fatty acid ester and polyglycerin fatty acid ester, those having HLB of 8 or more are preferable, those having 10 or more are more preferable, and those having 12 or more are particularly preferable. The upper limit value of the HLB value is not particularly limited, but is generally 18 or less, and preferably 17 or less.

Here, HLB is a hydrophilic-hydrophobic balance that is usually used in the field of surfactants, and a commonly used calculation formula such as the Kawakami formula can be used. In the present invention, the following Kawakami equation is adopted.
HLB = 7 + 11.7 log (M _w / M ₀ )
Here, the molecular weight M _w of the hydrophilic group, M ₀ is the molecular weight of the hydrophobic group.

Moreover, you may use the numerical value of HLB described in the catalog etc.
Further, as can be seen from the above formula, a surfactant having an arbitrary HLB value can be obtained by utilizing the additivity of HLB.

  Moreover, the powder composition in this invention may contain the surfactant mentioned below separately from the said (b) component and (c) component mentioned later. As the surfactant in the present invention, a nonionic surfactant (hydrophilic surfactant) that dissolves in an aqueous medium can greatly reduce the interfacial tension of the oil phase / water phase in the emulsion composition, As a result, it is preferable in that the particle diameter can be reduced.

  Examples of nonionic surfactants that can be used in the present invention include glycerin fatty acid esters, organic acid monoglycerides, propylene glycol fatty acid esters, polyglycerin condensed ricinoleic acid esters, sorbitan fatty acid esters, and polyoxyethylene sorbitan fatty acid esters. Etc. More preferred are sorbitan fatty acid esters and polyoxyethylene sorbitan fatty acid esters. In addition, the surfactant described above is not necessarily highly purified by distillation or the like, and may be a reaction mixture.

The sorbitan fatty acid ester used in the present invention preferably has 8 or more carbon atoms, more preferably 12 or more. Preferred examples of sorbitan fatty acid esters include sorbitan monocaprylate, sorbitan monolaurate, sorbitan monostearate, sorbitan sesquistearate, sorbitan tristearate, sorbitan isostearate, sorbitan sesquiisostearate, sorbitan oleate, sorbitan sesquioleate And sorbitan trioleate.
These sorbitan fatty acid esters can be used alone or in combination.

  As a commercial item, Nikko Chemicals Co., Ltd. make, NIKKOL SL-10, SP-10V, SS-10V, SS-10MV, SS-15V, SS-30V, SI-10RV, SI-15RV, SO-15 10V, SO-15MV, SO-15V, SO-30V, SO-10R, SO-15R, SO-30R, SO-15EX, manufactured by Daiichi Kogyo Seiyaku Co., Ltd., Sorgen 30V, 40V, 50V, 90, 110, manufactured by Kao Corporation, Rheodor AS-10V, AO-10V, AO-15V, SP-L10, SP-P10, SP-S10V, SP-S30V, SP-O10V, SP-O30V and the like. .

The polyoxyethylene sorbitan fatty acid ester used in the present invention preferably has a fatty acid having 8 or more carbon atoms, more preferably 12 or more. Moreover, as length (addition mole number) of the ethylene oxide of polyoxyethylene, 2-100 are preferable and 4-50 are more preferable.
Preferable examples of polyoxyethylene sorbitan fatty acid ester include sorbitan polyoxyethylene monocaprylate, sorbitan polyoxyethylene monolaurate, sorbitan polyoxyethylene monostearate, sorbitan polyoxyethylene dextearate, sorbitan polyoxyethylene tristearate Sorbitan polyoxyethylene isostearate, sorbitan polyoxyethylene sesquiisostearate, sorbitan polyoxyethylene oleate, sorbitan polyoxyethylene sesquioleate, sorbitan polyoxyethylene trioleate, and the like.
These polyoxyethylene sorbitan fatty acid esters can be used alone or in combination.

  As a commercial item, Nikko Chemicals Co., Ltd. make, NIKKOL TL-10, NIKKOL TP-10V, NIKKOL TS-10V, NIKKOL TS-10MV, NIKKOL TS-106V, NIKKOL TS-30V, NIKKOL TS-30V, NIKOL TS-30V NIKKOL TO-10V, NIKKOL TO-10MV, NIKKOL TO-106V, NIKKOL TO-30V, manufactured by Kao Corporation, Rheodor TW-L106, TW-L120, TW-P120, TW-S106V, TW-S120V, TW -S320V, TW-O106V, TW-O120V, TW-O320V, TW-IS399C, Rheodor Super SP-L10, TW-L120, manufactured by Daiichi Kogyo Seiyaku Co., Ltd., Sorgen TW-20, TW-60V TW-80V and the like.

  The amount of these other surfactants is preferably not more than 5 times the amount of the oil component, more preferably not more than 2 times, in order to easily obtain an emulsion having a fine particle size. The amount is more preferably 1.5 times or less, and particularly preferably 1 time or less. By making the amount of the surfactant 2 times or less, it is preferable in that the problem that foaming becomes severe tends to be eliminated.

0.01-30 mass% is preferable with respect to the whole powder composition, 0.1-30 mass% is more preferable, and, as for the addition amount of these arbitrary surfactants, 1-25 mass% is still more preferable.
By making the amount of the surfactant 0.01% by mass or more, it is easy to lower the interfacial tension between the oil phase / water phase when the emulsion composition is made, and by making it 30% by mass or less, This is preferable in that it does not easily cause problems such as the foaming of the emulsion composition becoming severe.

(C) Phospholipid The powder composition in the present invention contains phospholipid as the component (c).
The phospholipid here is an ester composed of fatty acid, alcohol, phosphoric acid and nitrogen compound among complex lipids, and is a group having phosphate ester and fatty acid ester, glycerophospholipid not containing glycerin, sphingolin containing sphingosine It refers to lipid.

Examples of glycerophospholipids that can be used in the present invention include phosphatidic acid, bisphosphatidic acid, lecithin (phosphatidylcholine), phosphatidylethanolamine, phosphatidylmethylethanolamine, phosphatidylserine, phosphatidylinositol, phosphatidylglycerin, diphosphatidylglycerin (cardiolipin) and the like. List of various lecithins derived from plants such as soybeans, corn, peanuts, rapeseed, wheat, etc., those derived from animals such as egg yolk and cows, and microorganisms such as Escherichia coli. Can do.
Examples of sphingophospholipids that can be used in the present invention include sphingomyelin.

In the present invention, the glycerophospholipid includes glycerophospholipid having one fatty acid residue in one molecule, that is, lysolecithin as a result of enzymatic degradation.
Such lysolecithin can be obtained by hydrolysis of lecithin with an acid or alkali catalyst, but it can also be obtained by hydrolysis of lecithin with phospholipase A ₁ or A ₂ .
Examples of such lysolecithin include lysophosphatidic acid, lysophosphatidylglycerin, lysophosphatidylinositol, lysophosphatidylethanolamine, lysophosphatidylmethylethanolamine, lysophosphatidylcholine (lysolecithin), lysophosphatidylserine and the like.

Furthermore, hydrogenated or hydroxylated glycerophospholipids typified by the above lecithin can also be used in the present invention.
The hydrogenation is performed, for example, by reacting lecithin with hydrogen in the presence of a catalyst, and the unsaturated bond of the fatty acid moiety is hydrogenated. Hydrogenation improves the oxidation stability of lecithin.
Moreover, the said hydroxylation heats a lecithin with high concentration hydrogen peroxide and organic acids, such as an acetic acid, tartaric acid, and butyric acid, and the unsaturated bond of a fatty-acid part is hydroxylated. Hydroxylation improves the hydrophilicity of lecithin.

  Among the above (c) phospholipids, those having two fatty acid residues in one molecule are preferable from the viewpoint of storage stability of the powder, and lecithin is particularly preferable.

Since the lecithin has a hydrophilic group and a hydrophobic group in the molecule, it has been widely used as an emulsifier in the food, pharmaceutical and cosmetic fields.
Further, hydrogenated and hydroxylated lecithin is particularly preferred for cosmetic use.

Although the lecithin having a purity of 60% by mass or more is industrially used as lecithin, in the present invention, a lecithin having a purity of 80% by mass or more generally called “high purity lecithin” is preferable. Preferably it is 90 mass% or more.
The lecithin purity (mass%) is determined by subtracting the weight of the toluene insoluble matter and the acetone soluble matter by utilizing the property that lecithin is easily dissolved in toluene and not dissolved in acetone. High-purity lecithin is preferred because it has higher lipophilicity than lysolecithin, and therefore, the compatibility between lecithin and the oil component is increased, and the emulsion stability can be improved.
The phospholipid used in the present invention can be used alone or in the form of a mixture of plural kinds.

In the powder composition of the present invention, the content of phospholipid is preferably 0.1 to 10% by mass, more preferably 0.2 to 8% by mass, and still more preferably 0 to the entire powder composition. 0.5 to 5% by mass.
When the content of the phospholipid is 0.1 mass or more, the emulsion stability of the emulsion composition tends to be good. Moreover, it is preferable from the viewpoint of the emulsion stability of an emulsion composition by making the said content into 10 mass% or less, without an excess phospholipid separating from an oil-based component and forming a phospholipid dispersion in water.

In the powder composition of the present invention, the composition ratio of the component (b) and the component (c) is the same or the component (b) is more. Since the component (b) is present in the powder composition in the same amount or more than the component (c), a fine particle size can be obtained, and the storage stability of the particle size and the storage stability of the emulsion can be improved. Can also be good.
The composition ratio of the component (b) and the component (c) is such that the amount of the component (b) is from the viewpoint of an appropriate amount for the finer particles and the emulsion stability, and from the viewpoint of adjusting foaming when the emulsion composition is used. It is preferably 1 to 100 times the component (c), more preferably more than 5 times and less than 80 times.

(D) Excipient The powder composition according to the present invention can preferably contain an excipient as the component (d) from the viewpoint of ease of pulverization.
The excipient may be any water-soluble substance that is generally used for stably granulating the oily component in the present powder composition. Glucose, fructose, lactose, maltose, deoxyribonucleic acid, sucrose Monosaccharides and polysaccharides such as dextrin, maltodextrin, cyclodextrin, maltose, fructose, inulin, trehalose; sugar alcohols such as sorbitol, mannitol, maltitol, lactose, maltotriitol, xylitol; sodium chloride, sodium sulfate, etc. Inorganic salts: Thickening polysaccharides such as gum arabic, guar gum, pectin, pullulan and sodium alginate; Cellulose derivatives such as methylcellulose and sodium carboxymethylcellulose; Denp subjected to esterification, etherification and terminal reduction treatment to starch Derivatives; Other modified starches, gelatin hydrolyzate, agar, and polyvinyl alcohol. Among these, monosaccharides, polysaccharides, sugar alcohols, and inorganic salts are preferable from the viewpoint of solubility, and gum arabic, inulin, dextrin, deoxyribonucleic acid, sugar alcohols, and inorganic salts are more preferable from the viewpoint of hygroscopicity and particle formation. Monosaccharides and polysaccharides are particularly preferred. Among them, gum arabic, inulin, dextrin, and deoxyribonucleic acid are particularly preferable, and inulin is most preferable. These can be used alone or in combination of two or more.
These excipients are preferably used in an amount of 20% by mass to 95% by mass, more preferably 30% by mass to 85% by mass with respect to the entire powder composition from the viewpoint of efficiently and satisfactorily retaining the oily component. .

In addition, although the powder composition in this invention can contain suitably another additive as needed, it is preferable not to contain the polyhydric alcohol liquid at normal temperature from a viewpoint of the ease of powderization. The polyhydric alcohol here means a dihydric or higher alcohol, for example, glycerin, diglycerin, triglycerin, polyglycerin, 3-methyl-1,3-butanediol, 1,3-butylene glycol, isoprene. Glycol, 1,2-pentanediol, 1,2-hexanediol, propylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol, diethylene glycol, pentaerythritol, neopentyl glycol, and the like. It can be used in the form of a mixture.
In the present invention, “not containing polyhydric alcohol that is liquid at room temperature” means 1% by mass or less, preferably 0.5% by mass or less, more preferably 0.1% by mass with respect to the entire powder composition. Most preferably, it is 0% by mass.

  A coating layer may be formed on the powder composition of the present invention. In order to form the coating layer, a solid or liquid coating treatment agent containing the above-mentioned emulsifier can be constituted. As such a coating treatment agent, when the coating layer is coated by a spray drying method, an aqueous solution in which the above surfactant is dissolved in an appropriate solvent such as water, alcohol, propylene glycol or the like, The emulsion composition containing the emulsifier may be a solid agent composed only of a surfactant. Content of the said surfactant in a coating processing agent can be suitably adjusted according to the dosage form of a coating processing agent.

As described above, the powder composition in the present invention uses the aqueous medium composed of water in which the hardness represented by (Formula 2) falls within a predetermined range, and the component (a) and the component (c) described above. It can be obtained by producing an emulsion composition containing etc. and drying it.
Preferably, using an aqueous medium composed of water having hardness as described above, the composition contains (a) component, (b) component, and (c) component, and the composition ratio of (b) and (c) is It can be obtained by a production method comprising a production step of producing an emulsion composition having the same or a larger ratio of (b) and a step of drying the obtained emulsion composition.

<Method for producing emulsion composition>
As described above, the method for producing an emulsion composition is as follows: I) a step of obtaining an aqueous phase using an aqueous medium composed of water in which the hardness represented by (Formula 2) is in a predetermined range; II) an oil phase Step of obtaining, III) A production method including a step of mixing an aqueous phase and an oil phase under stirring and emulsifying and dispersing to obtain an emulsion composition is preferred.
The components contained in the oil phase and the aqueous phase in the production method are the same as the constituents of the powder composition (or emulsion composition) of the present invention, and preferred examples and preferred amounts are also the same, and preferred combinations. Is more preferable.

The ratio (mass) of the oil phase to the aqueous phase in the emulsification dispersion is not particularly limited, but generally, the smaller the oil phase / water phase ratio, the smaller the particle diameter, but the oil phase If the / water phase ratio is too small, the active ingredient may be low, causing problems in practical use, and the surfactant concentration may be low, so that the emulsion stability of the emulsion composition may be deteriorated.
From the above viewpoint, the oil phase / water phase ratio (% by mass) is preferably 0.1 / 99.9 to 50/50, more preferably 0.5 / 99.5 to 30/70, and 1/99 to 20 /. 80 is more preferable.
At this time, the ratio of water in the emulsion composition is preferably 80% by mass or more, and more preferably 85% by mass or more from the viewpoint of miniaturization of the emulsion particles.

The emulsification dispersion may be carried out by one step of emulsification, but it is preferable to carry out two or more steps of emulsification from the viewpoint of obtaining uniform and fine emulsified particles.
Specifically, in addition to a one-step emulsification operation such as emulsification using a normal emulsification apparatus (for example, stirrer, impeller stirring, homomixer, continuous flow type shearing apparatus, etc.) utilizing a shearing action, a high-pressure homogenizer, etc. It is particularly preferable to use two or more types of emulsifiers together by a method such as emulsification. By using a high-pressure homogenizer, the emulsion can be arranged into even more uniform droplets of fine particles. Further, it may be performed a plurality of times for the purpose of forming a droplet having a more uniform particle diameter.

  The temperature condition for emulsifying and dispersing in the present invention is not particularly limited, but is preferably 10 to 100 ° C. from the viewpoint of the stability of the functional oil component, and depending on the melting point of the functional oil component to be handled, A preferable range can be appropriately selected.

Examples of the high-pressure homogenizer include a chamber-type high-pressure homogenizer having a chamber in which a flow path for processing liquid is fixed, and a homogeneous valve-type high-pressure homogenizer having a homogeneous valve. Among these, the homogeneous valve type high-pressure homogenizer can easily adjust the width of the flow path of the processing liquid and can arbitrarily set the pressure and flow rate during the operation, so that the operation range is wide, especially the emulsion composition according to the present invention. It is preferable for the manufacturing method of a thing.
In addition, although the degree of freedom of operation is low, a mechanism for increasing the pressure is easy to make. Therefore, when an ultra-high pressure is required, a chamber-type high-pressure homogenizer can be suitably used.

Examples of the chamber-type high-pressure homogenizer include a microfluidizer (manufactured by Microfluidics), a nanomizer (manufactured by Yoshida Kikai Kogyo Co., Ltd.), and an optimizer (manufactured by Sugino Machine Co., Ltd.).
As the homogeneous valve type high pressure homogenizer, Gorin type homogenizer (manufactured by APV), Lanier type homogenizer (manufactured by Lanier), high pressure homogenizer (manufactured by Niro Soavi), homogenizer (manufactured by Sanwa Machinery Co., Ltd.), high pressure homogenizer (Made by Izumi Food Machinery Co., Ltd.), ultrahigh pressure homogenizer (made by Ika Co., Ltd.) and the like.

In the present invention, the pressure of the high-pressure homogenizer is preferably 50 MPa or more, more preferably 50 to 250 MPa, and still more preferably 100 to 250 MPa.
Moreover, it is preferable from the viewpoint of maintaining the particle size of the dispersed particles that the emulsified liquid, which is an emulsified and dispersed composition, is cooled through some cooler within 30 seconds, preferably within 3 seconds immediately after passing through the chamber.

The emulsion composition obtained by such a process is an O / W emulsion in which emulsified particles containing an oil component are dispersed in an aqueous medium.
In particular, in the present invention, an emulsion composition in which fine emulsion particles are uniformly dispersed can be obtained.
The particle diameter (volume average particle diameter) of the emulsion composition obtained here is preferably 1 nm or more and 200 nm or less from the viewpoint of particle stability and transparency, and more preferably 130 nm from the viewpoint of transparency. Hereinafter, it is most preferably 90 nm or less.

In the present invention, the particle size of the emulsion composition can be measured with a commercially available particle size distribution meter or the like. Emulsion particle size distribution measurement methods include optical microscopy, confocal laser microscopy, electron microscopy, atomic force microscopy, static light scattering, laser diffraction, dynamic light scattering, centrifugal sedimentation, electricity A pulse measurement method, a chromatography method, an ultrasonic attenuation method, and the like are known, and apparatuses corresponding to the respective principles are commercially available.
In view of the particle size range and the ease of measurement in the present invention, the dynamic light scattering method is preferred for measuring the emulsion particle size in the present invention. As a commercially available measuring device using dynamic light scattering, Nanotrac UPA (Nikkiso Co., Ltd.), dynamic light scattering type particle size distribution measuring device LB-550 (Horiba, Ltd.), a concentrated particle size analyzer FPAR-1000 (Otsuka Electronics Co., Ltd.) etc. are mentioned.

The particle diameter in the present invention is a volume average particle diameter measured by a measuring method using a concentrated particle size analyzer FPAR-1000 (Otsuka Electronics Co., Ltd.). In the case of an emulsion composition, a 10% by mass aqueous solution is prepared, Measure under the standard measurement conditions of the equipment. On the other hand, in the case of a powder composition, a 1% by mass aqueous solution is prepared and measured under the same conditions as the emulsion composition.
In addition to the components of the emulsion composition, the particle size of the emulsion composition can be adjusted by factors such as the stirring conditions (shearing force / temperature / pressure) in the production method and the ratio of the oil phase to the water phase.

The emulsion composition obtained as described above is then subjected to drying in a drying step.
As a drying method applicable to this production method, any method usually used in this application may be used, and spray drying, freeze drying, vacuum drying, shelf drying, belt drying, drum drying are possible. And so on. Of these, spray drying and freeze drying are preferred from the viewpoint of handling the powder.
The emulsion drying process (powdering) and the method of forming the coating layer when it has a coating layer are described in "Highly functional powder and encapsulation technology for foods" published by Science Forum (2003), pages 163-145. Can be used.
For the drying process (pulverization), see pages 163-197. For the method of forming the coating layer, see 207-214 for fluidized bed coating. For devices that can be used for powdering and coating layer formation, see pages 223-245. Can be used.

By drying the emulsion composition by the above drying step, a powder composition in which the “total amount of calcium and magnesium” derived from water contained in 1 kg of the powder composition is in the range of 10 to 700 mg / kg can be obtained. .
In order to increase the total amount of calcium and magnesium within this range, for example, the above-mentioned water having a high hardness may be used, or the ratio of water necessary for making a powder composition may be increased, and conversely, the decrease In order to achieve this, water having a low hardness as described above may be used, or the proportion of water required to make a powder composition may be reduced.

The powder composition of the present invention thus obtained is an aqueous solution having good storage stability in terms of particle diameter, pigment and dispersibility of emulsion particles by re-dissolution in an aqueous medium according to the target product. An oil-type emulsion composition can be constituted.
The particle size in the emulsion composition obtained after re-dissolution should be an average particle size of 200 nm or less from the viewpoint of transparency and absorbability when an aqueous solution in which 1 g of the powder composition is dissolved in 300 mL of water. From the viewpoint of good transparency, dispersion stability, and various storage stability, it is preferably 1 nm or more and less than 130 nm.

The powder composition of the present invention has high water solubility. Here, “water-soluble” means that at least 0.1% by mass or more dissolves in water at 25 ° C.
On the other hand, the powder composition of the present invention has low hygroscopicity, and the water content as the powder composition is preferably in the range of 0.01% by mass to 10% by mass, and the water content is 0.1%. The range is more preferably from 5% by mass to 5% by mass, and still more preferably from 0.5% by mass to 3% by mass. The water content can be measured by a commonly used method such as a loss on drying method.

Thus, the powder composition of the present invention has not only transparency and dispersion stability, but also storage stability of the contained components, storage stability of the particle size, and storage stability as an emulsion. It is preferable to apply to compositions, cosmetic compositions and pharmaceutical compositions.
That is, the food composition, cosmetic composition, and pharmaceutical composition of the present invention each include the powder composition of the present invention.

Here, foods include beverages, frozen desserts, cosmetics include skin cosmetics (skin lotion, serum, milk, cream, etc.), lipsticks, sunscreen cosmetics, makeup cosmetics, etc. , Nourishment tonics and the like, but are not limited thereto.
In the case of preparing such a food composition, cosmetic composition, or pharmaceutical composition, the powder preparation of the present invention and any component that can be added to achieve the desired purpose are mixed by a conventional method. And get it.
Here, the present powder composition may be mixed with other components in a powdered state or redissolved in an aqueous medium according to the form of various target product compositions.

The amount of the powder composition of the present invention used for foods, cosmetics, pharmaceuticals and the like varies depending on the type and purpose of the product and cannot be specified unconditionally, but is 0.01 to 100% by mass based on the product A range is preferred. In addition, when adding to cosmetics, a foodstuff, and a pharmaceutical for the objective of coloring, it is preferable to add and use so that it may become the range of 0.05-50 mass%.
If the addition amount is 0.01% by mass or more, the content of the oily component containing at least one of the functional oily components is often a content that can be expected as a product, even if it is 50% by mass or more, In the case of uses such as tablets and hard capsules, appropriate effects can be exhibited.

  The powder composition of the present invention can be stored for a long time as a powder. In particular, it can be redissolved to dissolve in water-soluble products such as beverages (in the case of food), lotions, cosmetics, emulsions, cream packs / masks, packs, hair washing When used for cosmetics, fragrance cosmetics, liquid body cleansers, UV care cosmetics, deodorant cosmetics, oral care cosmetics (in the case of cosmetics), etc., a transparent product is obtained, and long-term storage or sterilization It is possible to suppress the occurrence of inconvenient phenomena such as precipitation, precipitation or neck ring of insoluble matter under severe conditions such as treatment.

  EXAMPLES Hereinafter, although an Example demonstrates this invention, this invention is not limited to this. In the following description, “parts” and “%” are based on mass unless otherwise specified.

[Example 1]
Preparation of Emulsion Composition EM-1-7 and Powder Composition PW-1-7 <1-1: Preparation of Emulsion Composition EM-1-7>
Emulsion composition EM-1 was prepared by the following composition and the following production method.

<Composition>
(Ingredient) (mass%)
(1) Haematococcus alga pigment (astaxanthin content 21% by mass) ^{* 1}
2.7
(2) Mixed tocopherol ^{* 2} 0.5
(3) Sucrose laurate ^{* 3} 2.0
(4) Polyglyceryl laurate-10 ^{* 4} 0.7
(5) Lecithin ^{* 5} 0.4
(6) Acacia gum ^{* 6} 11.4
(7) Water used (as listed in Table 1) 82.3
* 1: ASTOTS-S: Takeda Shiki Co., Ltd. * 2: RIKEN E Oil 800: Riken Vitamin Co., Ltd. * 3: Ryoto Sugar Ester L-1695: Mitsubishi Chemical Foods Co., Ltd. (HLB = 16)
* 4: NIKKOL Decaglyn 1-L: Nikko Chemicals Co., Ltd. (HLB = 15.5)
* 5: Recion P: Riken Vitamin Co., Ltd. * 6: INSTANTGUM AB: Colloid Naturel Japan Co., Ltd.

<Production method>
(A) The above components (1) to (2) are weighed into a container, heated and mixed with stirring in a thermostatic bath at 70 ° C., confirmed to be well mixed, and kept at 70 ° C. to obtain a mixture A It was.
(B) The above components (3) to (7) are weighed in a container, heated and mixed with stirring in a constant temperature bath at 70 ° C., confirmed to be well mixed, heated and mixed, and kept at 70 ° C., Mixture B was obtained.
(C) The mixture A was added to the mixture B, mixed, and uniformly emulsified. As the emulsifier, a homogenizer (manufactured by SMT) was used, and the mixture was stirred at 10,000 rpm for 5 minutes to obtain a mixture C.
(D) The mixture C was emulsified using a high-pressure homogenizer (Ultimizer HJP-25005: manufactured by Sugino Machine Co., Ltd.) at a pressure of 245 MPa and a liquid temperature of 60 ° C. to obtain an emulsion composition EM-1.
Subsequently, except having changed said (7) component [use water] into the component of Table 1, it carried out similarly to emulsion composition EM-1, and obtained emulsion composition EM-2-7.

<1-2: Preparation of powder composition PW-1-7>
The emulsion compositions EM-1 to EM-7 obtained in 1-1 are fed at a rate of 12 mL / min with a spray dryer (ADL310: manufactured by Yamato Scientific Co., Ltd.) and spray-dried by blowing air at 170 ° C. The powder compositions PW-1 to 7 were prepared. When the average particle diameter of each powder composition PW-1-7 was measured with the particle size distribution analyzer (Corporation | KK Japan laser, brand name: HELOS), all were 22 micrometers. The water content (%) of each powder composition PW-1 to 7 was measured by the loss on drying method. The results are shown in Table 1.
The re-dissolved particle size of each powder composition PW-1 to 7 is the average particle size of samples 1 to 7 in which 1 g of the powder composition is dissolved in 300 mL of water, using a particle size distribution meter (FPAR-1000: manufactured by Otsuka Electronics). It was measured. Table 1 shows the compositions and re-dissolved particle sizes of the powder compositions PW-1 to 7 (Samples 1 to 7).

[Example 2]
Preparation of Powder Composition PW-11-17 <2-1: Preparation of Powder Composition PW-11-17>
In place of the excipient acacia gum used in Example 1, powder compositions PW-11 to 17 were obtained in the same procedure as in Example 1 except that the same amount of excipient shown in Table 2 was used.

<Evaluation of powder composition>
Evaluation of the powder composition was performed as follows.
(1) Evaluation of re-solubility of powder composition A liquid sample was prepared by re-dissolving 0.5 g of the powder composition in 150 g of water, followed by stirring at 25 ° C for 2 to 10 minutes. Thereafter, the state of the sample after redissolving was observed visually and with an optical microscope.
Scores were assigned according to the following criteria, and the results are shown in Tables 3 to 4.
3: Complete dissolution in 2 minutes.
2: Complete dissolution in 10 minutes.
At the time when 1:10 minutes passed, some were not dissolved and so-called lumps were formed.
(2) Preservability of powder (preservation appearance)
The powder composition was stored for 30 days at a temperature of 40 ° C. and a relative humidity of 60%. The state of the subsequent powder composition was observed visually and with an optical microscope.
Scores were assigned according to the following criteria, and the results are shown in Tables 3 to 4.
3: Aggregation (solidification) of particles was not observed.
2: Although there was some aggregation (solidification) of the grains, it was not at a level causing a practical problem.
1: Agglomeration (solidification) of grains was observed.

(3) Evaluation of storage stability of emulsion (solubility after storage)
Each of the powder compositions was divided into two, one was filled in a 100 ml glass bottle without any gap and stored for 30 days at a temperature of 40 ° C. and a relative humidity of 60%. Store the other in the dark (5 ° C). Thereafter, 1 g of each powder composition was redissolved in 300 mL of water so that the content of the oil component was 0.58% by mass, and a liquid sample was prepared and stirred at 25 ° C. for 10 minutes. The transparency of the sample redissolved after being stored for 30 days and the sample redissolved after being stored in a refrigerated (5 ° C.) dark place were evaluated by the following measuring methods.

(Evaluation A)
Using pure water as a control, the absorbance at 750 nm of each measurement solution is measured with a spectrophotometer (manufactured by JASCO Corporation).
A score was assigned according to the following criteria based on the obtained absorbance. The results are shown in Tables 3-4.
3: Transparency did not deteriorate due to storage.
2: Transparency was slightly degraded by storage, but it was not at a level that would cause a practical problem.
1: Clearly the transparency deteriorated by storage.

(Evaluation B)
The particle size distribution meter (FPAR-1000: Otsuka) used for (Evaluation A) was measured for the average particle size of the sample redissolved after storage for 30 days and the sample redissolved after storage in the dark (5 ° C). Measured by Electronic).
The obtained average particle diameter was rated according to the following criteria. The results are shown in Tables 3-4.
3: The average particle diameter did not change by storage. (Less than ± 5nm)
2: Transparency was slightly degraded by storage, but it was not at a level that would cause a practical problem.
(± 5nm or more, less than 10nm)
1: Clearly the transparency deteriorated by storage. (± 10nm or more)

(4) Evaluation of powder appearance The appearance of the powder composition was visually observed.
Scores were assigned according to the following criteria, and the results are shown in Tables 3 to 4.
3: The whole looks uniform.
2: Although there was a part of nonuniformity (example: uneven color), it was not a practically problematic level.
1: A non-uniform portion (eg, uneven color) was observed.

As described above, the powder composition of the present example does not show aggregation or the like even under high humidity, has good storage stability and re-dissolution property, and exhibits good transparency even after re-dissolution. Can do. In addition, the powder composition is good without non-uniformity in appearance.
Therefore, according to the present invention, it is possible to provide a powder composition that exhibits good storage stability, re-dissolvability, and transparency after re-dissolution.

Claims (13)

A water-soluble powder composition comprising an oily component containing at least one functional oily component, a phospholipid, and an excipient, the powder composition comprising the oily component in the presence of a phospholipid, Emulsifying in an aqueous medium composed of water having a hardness of 10 mg / L to 140 mg / L expressed by the following (formula 2) to obtain an emulsion composition, and drying the emulsion composition It is manufactured by a manufacturing method including,
The functional oil component is carotenoid pigment, dl-α-tocopherol, dl-β-tocopherol, dl-γ-tocopherol, dl-δ-tocopherol, α-tocotrienol, β-tocotrienol, γ-tocotrienol, and δ-tocotrienol. At least one selected from the group consisting of:
The powder composition whose "calcium and magnesium total amount" derived from water contained per 1 kg of the powder composition represented by the following (Formula 1) is in the range of 10 mg / kg to 700 mg / kg .
(Formula 1) Calcium and magnesium total amount (mg / kg) = [calcium amount (mg / kg)] × 2.5 + [magnesium amount (mg / kg)] × 4.1
(Formula 2) Calcium and magnesium total amount (mg / L) = [calcium amount (mg / L)] × 2.5 + [magnesium amount (mg / L)] × 4.1 2. The powder composition according to claim 1, wherein the “total amount of calcium and magnesium” represented by (Formula 1) is in the range of 140 mg / kg to 500 mg / kg .   The powder composition contains (a) an oily component containing at least one functional oily component, (b) a sucrose fatty acid ester and / or a polyglycerol fatty acid ester, (c) a phospholipid, and (b) The powder composition according to claim 1 or 2, which is a powder composition obtained by drying an emulsion composition in which the composition ratio of (c) and (c) is the same or the ratio of (b) is greater. The powder composition according to any one of claims 1 to 3 , wherein an average particle diameter of emulsion particles obtained when 1 g of the powder composition is dissolved in 300 mL of water is in a range of 1 nm or more and less than 130 nm. The powder composition according to any one of claims 1 to 4 , wherein the phospholipid has two fatty acid residues in one molecule. The powder composition according to any one of claims 1 to 5 , wherein the excipient is a monosaccharide or a polysaccharide. The powder composition according to claim 6 , wherein the excipient is inulin. The powder composition according to any one of claims 1 to 7 , wherein a moisture content of the powder composition is 0.5% or more and 3.0% or less. A method for producing a water-soluble powder composition comprising an oily component containing at least one functional oily component and a phospholipid and an excipient,
Emulsifying the oily component in an aqueous medium composed of water having a hardness represented by the following (formula 2) of 10 mg / L to 140 mg / L in the presence of phospholipid to obtain an emulsion composition;
The emulsion composition is dried, and the water-derived “total amount of calcium and magnesium” contained in 1 kg of the powder composition represented by the following (formula 1) is in the range of 10 mg / kg to 700 mg / kg Obtaining a composition (Formula 1) Calcium and magnesium total amount (mg / kg) = [calcium amount (mg / kg)] × 2.5 + [magnesium amount (mg / kg)] × 4.1
(Formula 2) Calcium and magnesium total amount (mg / L) = [calcium amount (mg / L)] × 2.5 + [magnesium amount (mg / L)] × 4.1
Only contains the functional oil component, carotenoids, dl-alpha-tocopherol, dl-beta-tocopherol, dl-.gamma.-tocopherol, dl-.delta.-tocopherol, alpha-tocotrienol, beta-tocotrienol, .gamma.-tocotrienol, And a method for producing a powder composition which is at least one selected from the group consisting of δ-tocotrienol . The emulsion composition contains (a) an oily component containing at least one functional oily component, (b) a sucrose fatty acid ester and / or a polyglycerin fatty acid ester, (c) a phospholipid, and (b) 10. The method for producing a powder composition according to claim 9 , wherein the composition ratio of (c) and (c) is the same or the ratio of (b) is greater. The food composition containing the powder composition in any one of Claims 1-8 . A cosmetic composition comprising the powder composition according to any one of claims 1 to 8 . The pharmaceutical composition containing the powder composition in any one of Claims 1-8 .