JP5570693B2 - Makeup method - Google Patents

Description

  The present invention relates to a cosmetic method using a plurality of cosmetics in order to efficiently infiltrate ingredients effective as cosmetics.

  Cosmetics contain whitening agents, wrinkle improving agents, blood circulation promoters and the like as active ingredients, and these are used to penetrate the skin and improve the skin. However, the skin has a barrier function, which prevents the entry from the outside world and prevents the release of the body components to the outside. For this reason, there is a problem that it is difficult to sufficiently penetrate the skin with the active ingredient contained in the cosmetic.

  For such problems, as a method of infiltrating the active ingredient, a method of using a permeation promoting ingredient in combination with the active ingredient (Patent Document 1), a method of using a skin medicinal ingredient in combination with a specific fluorinated polymer (Patent Document) 2) is known. However, these methods are not satisfactory in terms of feeling of use because the active ingredient cannot be sufficiently permeated or the polymer film gives a sense of incongruity.

Moreover, although the method (patent document 3) which apply | coats alkaline cosmetics to skin and permeate | transmits an active ingredient is also known, stability of cosmetics and the usability | use_condition were not satisfied.
JP-A-10-194920 JP 2000-327556 A Special table 2004-500360 gazette

  An object of the present invention is to provide a cosmetic method having an excellent usability by efficiently penetrating an active ingredient contained in a cosmetic.

  The present inventors use a plurality of cosmetics, make the environment in which the active ingredient easily penetrates the skin with the first cosmetic, and then use the cosmetic containing the active ingredient to give the active ingredient. Finally, the present inventors have found a combination of cosmetics and a method of using the same as a system for protecting the skin by effectively infiltrating and finally returning the skin barrier function to a normal state.

That is, the present invention provides the following cosmetics (A), (B), and (C):
(A) a cosmetic having a pH of 6 to 8.5,
(B) 1 or more types of active ingredients which are pH 6-8.5, and are chosen from a whitening agent, a wrinkle improving agent, a ceramide production promoter, a blood circulation promoter, a moisturizer, an anti-inflammatory agent, an antioxidant, and a cell activator. Cosmetics containing,
(C) a cosmetic having a pH of 4.5 or more and less than 6;
A cosmetic method using the cosmetic, wherein the cosmetic (A) is first used, the cosmetic (B) is used, and the cosmetic (C) is further used.
Moreover, this invention is the following cosmetics (A), (B), and (C):
(A) a cosmetic having a pH of 6 to 8.5,
(B) 1 or more types of active ingredients which are pH 6-8.5, and are chosen from a whitening agent, a wrinkle improving agent, a ceramide production promoter, a blood circulation promoter, a moisturizer, an anti-inflammatory agent, an antioxidant, and a cell activator. Cosmetics containing,
(C) a cosmetic having a pH of 4.5 or more and less than 6;
And a cosmetic kit for using the cosmetic (B) and further using the cosmetic (C).

  According to the present invention, by using a plurality of cosmetics, the active ingredients contained in the cosmetics can be efficiently penetrated, and the feeling of use is excellent.

[Cosmetics (A)]
The cosmetic (A) used in the present invention is set to pH 6 to 8.5, preferably pH 6 to 8. By setting to this range, it is possible to create an environment in which the active ingredient easily penetrates into the skin efficiently. In addition, when a cosmetic material having a pH higher than 8.5 is used, it is possible to make the environment easy to penetrate, but the stability and feeling of use of the cosmetic material cannot be sufficiently satisfied.
For adjusting the pH, an organic acid, an inorganic acid, or a base can be used, and a monovalent to polyvalent acid or base can be used, respectively. These are preferably composed of acids and bases having valences which are not the same, and a part thereof may constitute a salt. By comprising an acid or base having valences which are not the same, it can have a buffering action. By applying a buffering action, a predetermined pH can be maintained for a long time when applied to the skin. By setting in this way, it is possible to set a skin environment in which an active ingredient contained in the cosmetic (B) to be used next easily penetrates.

  Examples of the acid component contained in the cosmetic (A) include citric acid, succinic acid, tartaric acid, acetic acid, malic acid, oxalic acid, lactic acid, boric acid, adipic acid and the like as organic acids, and hydrochloric acid as hydrochloric acid. , Phosphoric acid, sulfuric acid, sulfurous acid, nitric acid and the like. Examples of these acid salts include alkali metal salts such as sodium and potassium; alkanolamine salts such as monoethanolamine and triethanolamine; aminomethylpropanol salts and the like.

More specifically, citric acid, sodium citrate, phosphoric acid, sodium dihydrogen phosphate, sodium monohydrogen phosphate, succinic acid, sodium succinate, tartaric acid, sodium tartrate, acetic acid, sodium acetate, boric acid, lactic acid, Examples include sodium lactate, malic acid, oxalic acid, and adipic acid.
In particular, phosphoric acid and its salt, succinic acid and its salt, and citric acid and its salt are preferable.
Furthermore, a polyvalent acid having a buffering capacity and a salt thereof are preferable.

  The total mass of these acids and bases is preferably 0.01 to 10% by mass in the cosmetic (A), particularly 0.01 to 8% by mass, and more preferably 0.03 to 8%. It is preferable from the viewpoint of the setting of the skin environment that promotes the penetration of the active ingredient and from the point of feel after application.

Moreover, cosmetics (A) can contain guanidines and can further enhance the penetration effect.
As guanidines and salts thereof, general formulas (1), (2) and (3):

[In the formula (1), B and D are the same or different and each represents an alkylene group having 2 to 8 carbon atoms, and L represents a bond, —CO— or an optionally substituted carbon group having 1 to 6 carbon atoms. M represents a hydrogen atom, a lower alkyl group, an aralkyl group or an aryl group which may have a substituent, j represents a number of 1 to 6, and k represents a number of 0 to 6. R ¹ represents a hydrogen atom, a lower alkyl group, or — (BO) _j — (DO) _k -LM. In formula (2), m represents a number from 1 to 10, G represents a hydrogen atom, a hydroxy group, a carboxyl group, a sulfonic acid group or a phosphoric acid group, and R ¹ has the same meaning as described above.

A heterocyclic group selected from azetidine, pyrrolidine, piperidine, piperazine and morpholine, wherein R ² and R ³ are the same or different and each represents a hydrogen atom, an alkyl group, a hydroxyalkyl group, a carboxyl group, a carboxyalkyl group or an amidino group; Show)
The thing represented by is mentioned.

  In the general formula (1), the alkylene group having 2 to 8 carbon atoms represented by B and D may be either a straight chain or branched chain, for example, an ethylene group, a trimethylene group, a tetramethylene group, a pentamethylene group, Examples include a hexamethylene group and a propylene group. Among these, those having 2 to 6 carbon atoms are preferable, and those having 2 to 4 carbon atoms, ethylene group, trimethylene group and propylene group are particularly preferable.

  The alkylene group having 1 to 6 carbon atoms represented by L may be either a straight chain or branched chain, for example, methylene group, ethylene group, trimethylene group, tetramethylene group, pentamethylene group, hexamethylene group, propylene group. Etc.

Examples of the lower alkyl group represented by M or R ¹ include a linear or branched alkyl group having 1 to 5 carbon atoms, such as a methyl group, an ethyl group, an n-propyl group, an isopropyl group, and n-butyl. Group, sec-butyl group, tert-butyl group, pentyl group and the like, and methyl group is particularly preferable. Examples of the aralkyl group represented by M include those having 7 to 12 carbon atoms such as a benzyl group and a phenethyl group. Examples of the aryl group represented by M include a phenyl group and a naphthyl group. Examples of the substituent include an amino group which may be substituted with a lower alkyl group such as a methyl group; a nitro group; a cyano group; A hydroxyl group; a carboxylic acid residue which may be esterified with a lower alkyl group, a halogenated lower alkyl group or an aralkyl group; a carbamoyl group; a halogen atom such as fluorine, chlorine, bromine or iodine; a methyl group, an ethyl group, And lower alkyl groups such as propyl group and isopropyl group; lower alkoxyl groups such as methoxy group and ethoxy group.

  j shows the number of 1-6, and the number of 1-4 is preferable. k shows the number of 0-6, and 0-4 are preferable.

In general formula (2), R ¹ is the same as above. m shows the number of 1-10, and 1-5 are preferable. G is preferably a hydroxy group, a carboxyl group, or a phosphoric acid group.

  Examples of such guanidines represented by the general formula (1) or (2) include 2-hydroxyguanidine, 3-hydroxyguanidine, 2-hydroxypropylguanidine, 4-hydroxybutylguanidine, 5-hydroxypentylguanidine, 6-hydroxyhexylguanidine, 2- (2-hydroxyethoxy) ethylguanidine, 2- [2- (2-hydroxyethoxy) ethoxy] ethylguanidine, 1- (3-hydroxypropyl) -1-methylguanidine, 1- ( 2-hydroxypropyl) -1-methylguanidine, 1- (4-hydroxybutyl) -1-methylguanidine, (2-methoxyethyl) guanidine, (2-ethoxyethyl) guanidine, (3-methoxypropyl) guanidine, ( 2-Methoxypropyl) guanidine (4-methoxybutyl) guanidine, 1- (2-methoxyethyl) -1-methylguanidine, 1- (2-ethoxyethyl) -1-methylguanidine, 1- (3-methoxypropyl) -1-methylguanidine, 1- (2-methoxypropyl) -1-methylguanidine, 2-guanidinoethyl acetate, 3-guanidinopropyl acetate, 2-guanidino-2-propyl acetate, 4-guanidino-1-butyl acetate, 5-guanidino-1 acetate -Pentyl, 6-guanidino-1-hexyl acetate, 2- (2-guanidinoethoxy) ethyl acetate, 2-guanidinoethyl benzoate, 3-guanidinopropyl benzoate, 2-guanidino-2-propyl benzoate, benzoic acid 4 -Guanidino-1-butyl, 5-guanidino-1-pentyl benzoate, 6-guanidino benzoate 1-hexyl, 2- (2-guanidinoethoxy) ethyl benzoate, 2-guanidinoethyl salicylate, 3-guanidinopropyl salicylate, m or p-hydroxybenzoic acid 2-guanidinoethyl, m or p-hydroxybenzoic acid 3-guanidino Propyl, m or p-hydroxybenzoic acid 2-guanidino-2-propyl, m or p-hydroxybenzoic acid 4-guanidino-1-butyl, m or p-hydroxybenzoic acid 5-guanidino-1-pentyl, m or p Examples include 6-guanidino-1-hexyl-hydroxybenzoate, m or 2- (2-guanidinoethoxy) ethyl p-hydroxybenzoate.

  Of these, 2- (2-hydroxyethoxy) ethylguanidine, guanidinoethoxyethanol, guanidinopentanol, guanidinopropanoic acid, and guanidinoethylphosphoric acid are particularly preferable.

  In general formula (3), pyrrolidine, piperidine, piperazine and morpholine are preferred as the heterocyclic group.

The alkyl group represented by R ² and R ³ include linear or branched alkyl group having 1 to 6 carbon atoms, more preferably an alkyl group having 1 to 4 carbon atoms. Specific examples of the alkyl group include a methyl group, an ethyl group, an n-propyl group, and an isopropyl group, and a methyl group is particularly preferable. As a hydroxyalkyl group, a C1-C6 hydroxyalkyl group is mentioned, A C1-C4 hydroxyalkyl group is more preferable. Specific examples of the hydroxyalkyl group include a hydroxymethyl group, a hydroxyethyl group, a hydroxypropyl group, and the like, and a hydroxymethyl group and a hydroxyethyl group are particularly preferable. Moreover, as a carboxyalkyl group, a C2-C7 carboxyalkyl group is mentioned, A C2-C5 carboxyalkyl group is more preferable. Specific examples of the carboxyalkyl group include a carboxymethyl group, a carboxyethyl group, a carboxypropyl group, a carboxybutyl group, and the like, and a carboxymethyl group and a carboxyethyl group are particularly preferable.
R ² and R ³ may be the same or different.

  The guanidines (3) have stereoisomerism due to the presence of an asymmetric carbon atom. In the present invention, any of these stereoisomers and mixtures thereof can be used.

Specific examples of guanidines (3) include N-amidino-proline, 2-hydroxymethyl-1-pyrrolidinecarboxamidine, 3-hydroxy-1-pyrrolidinecarboxamidine, N-amidino-aziridine-2-carboxylic acid N-amidino-2-piperidinecarboxylic acid, N-amidino-3-piperidinecarboxylic acid, N-amidino-4-piperidinecarboxylic acid, N-amidino-4-piperidinepropionic acid, N-amidinopyrrolidine, N-amidinopiperidine N-amidino-2-methylpiperidine, N-amidino-3-methylpiperidine, N-amidino-4-methylpiperidine, N-amidino-2-methylmorpholine, N-amidino-3-methylmorpholine, N-amidino- N′-methylpiperazine, N-amidino-N′-hydroxyethyl Perazine, N, N'-diamidino - piperazine.
Of these guanidines (3), N-amidino-proline, 2-hydroxymethyl-1-pyrrolidinecarboxamidine, and 3-hydroxy-1-pyrrolidinecarboxamidine are particularly preferable.

The acid for forming the salt of these guanidines (1), (2), (3) may be either an organic acid or an inorganic acid. For example, formic acid, acetic acid, propionic acid, butyric acid, isobutyric acid, hexane Acid, heptanoic acid, octanoic acid, nonanoic acid, decanoic acid, lauric acid, myristic acid, palmitic acid, stearic acid, acrylic acid, methacrylic acid, crotonic acid, isocrotonic acid, phenylacetic acid, cinnamic acid, benzoic acid, sorbic acid Monocarboxylic acids such as nicotinic acid, urocanic acid, pyrrolidone carboxylic acid; oxalic acid, malonic acid, succinic acid, glutamic acid, adipic acid, pimelic acid, corkic acid, azelaic acid, sebacic acid, maleic acid, fumaric acid, phthalic acid , Dicarboxylic acids such as terephthalic acid; glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, o, m or p-hydro Hydroxy acids such as benzoic acid; glycine, alanine, β-alanine, valine, leucine, phenylalanine, tyrosine, serine, threonine, methionine, cysteine, cystine, proline, hydroxyproline, pipecolic acid, tryptophan, aspartic acid, asparagine, glutamic acid Amino acids such as glutamine, lysine, histidine, ornithine, arginine, and aminobenzoic acid; lower alkyl sulfonic acids such as methanesulfonic acid and trifluoromethanesulfonic acid; arylsulfonic acids such as benzenesulfonic acid and p-toluenesulfonic acid; Examples thereof include hydrohalic acids such as hydroacid, hydrochloric acid, hydrobromic acid and hydroiodic acid; and inorganic acids such as perchloric acid, sulfuric acid, nitric acid, phosphoric acid and carbonic acid.
Of the acids for forming these guanidine salts, succinic acid, glutamic acid, lactic acid, and citric acid are particularly preferable.

  One or more guanidines or salts thereof can be used, and 0.001 to 30% by mass, particularly 0.001 to 20% by mass, and more preferably 0.01 to 10% by mass in the cosmetic (A). It is preferable from the viewpoint of setting the skin environment that promotes the penetration of the active ingredient and from the viewpoint of feeling of use.

[Cosmetics (B)]
The cosmetic (B) used in the present invention is set to pH 6 to 8.5, preferably pH 6 to 8. By setting to this range, it is possible to create an environment in which the active ingredient easily penetrates into the skin efficiently. Examples of the acid and salt thereof contained in the cosmetic (B) include those used in the cosmetic (A), and the type of acid and salt is not limited.

  Further, the combined mass of these acids and bases is preferably 0.01 to 10% by mass, particularly 0.01 to 8% by mass, and more preferably 0.03 to 8% by mass. From the viewpoint of promoting penetration and from the point of touch after application, it is preferable.

  The cosmetic (B) contains one or more active ingredients selected from a whitening agent, a wrinkle improving agent, a ceramide production promoter, a blood circulation promoter, a moisturizer, an anti-inflammatory agent, an antioxidant and a cell activator. To do.

  The whitening agent is not particularly limited as long as it is used in normal cosmetics, for example, hydroquinones such as ascorbic acid and arbutin, kojic acids, tranexamic acids, ellagic acids, lucinols, linoleic acids, alkoxysalicylic acids, Chamomile extract, glutathione, tocotrienol, ferulic acid, raspberry ketone, adenosine monophosphate, levocarnitine chloride, polyphenols, acerola extract, almond extract, altea extract, aloe extract, ages (Nebara) extract, ougon ( Koganebana extract, fire spine extract, cuckoo extract, kiwi extract, gardenia extract, clara extract, chlora extract, rice bran extract, peony extract, jellyfish ) Extract, Sakuhakuhi ( Wa) extract, soybean extract, tea extract, safflower (cured) extract, melissa (perfume mint) extract, clove extract, Coix (Job's tears) extract, placental extract, and the like.

  Among these, ascorbic acids are not particularly limited. For example, ascorbic acid phosphate and its salt, ascorbic acid sulfate and its salt, ascorbic acid alkali metal salt, ascorbic earth metal salt, ascorbine Preferred examples include acid aluminum salts, 2-O-α-D-glucosyl-L-ascorbic acid, ascorbyl tetra-2-hexyldecanoate and the like. Among these whitening agents, L-ascorbic acid-2-O-glucoside, arbutin, kojic acid, linoleic acid, tranexamic acids, ellagic acid, lucinols, and chamomile extract are particularly preferable.

  One or more kinds of these whitening agents can be used, and 0.00001 to 30% by mass, particularly 0.0001 to 20% by mass, and further 0.0001 to 10% by mass are contained in the cosmetic (B). However, it is preferable because a sufficient whitening effect is obtained and the feeling of use and stability are excellent. However, when the active ingredient is an animal or plant extract, the dry solid content is used.

  The wrinkle improving agent is not particularly limited as long as it is used in normal cosmetics. For example, guanidines and salts thereof; animals or plants such as a foliage extract, a malonier extract, a lemon extract, a yeast extract, etc. An extract is mentioned.

  Examples of guanidines and salts thereof are the same as those used in the cosmetic (A), and the same are preferable.

  One or more kinds of wrinkle improving agents can be used, and 0.00001 to 50% by mass, particularly 0.0001 to 30% by mass, and further 0.0001 to 20% by mass are contained in the cosmetic (B). From the viewpoints of usability, moisturizing effect, skin roughness prevention / improvement effect, and wrinkle formation prevention / improvement effect. However, when the active ingredient is an animal or plant extract, the dry solid content is used.

The ceramide production promoter is not particularly limited as long as it is used in ordinary cosmetics, and examples thereof include eucalyptus extract.
One or more ceramide production promoters can be used, and 0.00001 to 30% by mass, particularly 0.0001 to 20% by mass, and further 0.0001 to 10% by mass in the cosmetic (B). However, a higher moisturizing effect, an effect of preventing and improving rough skin are obtained, and it is preferable in terms of feeling in use and stability. However, when the active ingredient is an animal or plant extract, the dry solid content is used.

  The blood circulation promoter is not particularly limited as long as it is used in normal cosmetics, and examples thereof include vitamin E esterified products, nicotinic acid esters, and orotic acid esters. Methyl and the like are used.

  In addition, as plant extracts having a blood circulation promoting effect, extracts specified in 1986, such as fragrance journal extra volume 6 published in 1986 and fragrance journal extra volume 1 published in 1979, such as Arnica, Hawthorn , Kina, Salvia, Bodaige, Panax ginseng, Tomato, Mannenrou, Hypericum, Ginkgo, Melissa, Ononis, Assembly, Garlic, Chamomile, Syme, Nettle, Pepper, Hops, Western Redwood, Lavender, Carrot, Pepper, Kay, Pine, Ginseng, Elderberry, Yamazeri, Hashirokokoro, Button, Yamamomo, Dokudami, Kouhone, Shibugaki, Tokisenko, Gibijinsou, Gentian, Grape, Amaranthus, Daidai, Yuzu, Shobu, Natsumikan, Hamamelis, Maryroth, Pagan, pepper, mugwort, Enmeisou, rice (rice germ), Clara, and the like can be used plant extracts such as clove.

  Among these, as the compound, tocopherol nicotinate, tocopherol acetate, and nicotinic acid amide are preferable, and as the plant extract, Yuzu extract, assembly extract, hypericum extract, ginkgo biloba extract, arnica extract, quina extract, clam essence extract, Tokinsenka extract, Prunus extract, salvia extract, kingfish extract, salamander extract, rice germ oil, body extract and extract are preferred.

  One or more kinds of these blood circulation promoters can be used, and 0.00001 to 30% by mass, particularly 0.0001 to 20% by mass, and further 0.0001 to 10% by mass are contained in the cosmetic (B). This is preferable from the viewpoints of a feeling of use and stability, and a higher moisturizing effect, an effect of preventing / improving rough skin, an effect of preventing / improving dullness of skin color, an effect of preventing / improving spots and freckles, and the like. However, when the active ingredient is an animal or plant extract, the dry solid content is used.

  The moisturizing agent is not particularly limited as long as it is used in normal cosmetics. Derivatives, chitin, chitosan, gelatin, pectin, pyrrolidone carboxylic acid or salts thereof, marine mucin, glycolic acid, heparin, chondroitin (sodium chondroitin sulfate), vegetable (phyto) ceramide, ceramide, trehalose, urea and other NMF components, Examples include phospholipids such as lecithin and hydrogenated lecithin, lactic acid or a salt thereof, sodium hyaluronate, lactoferrin, sulfated trehalose, and the like.

  Animal or plant extracts include alfalfa extract, akebi extract, fennel extract, witch hazel extract, turmeric extract, yellowfin extract, licorice extract, common mugwort extract, grape extract, comfrey ( Cypress extract, Savonso extract, Cactus extract, Hawthorn extract, Giant extract, Perilla extract, Birch extract, Horsetail extract, Mulberry extract, Soybean extract, Perilla extract Extract, butcher's bloom extract, loofah extract, mulberry extract, peach extract, yukinoshita extract, raspberry extract, lotus extract, rose extract, rosemary (mannenrou) , Lily extract, barley (malt root) extract, wheat extract, apricot extract, oat extract, corn extract, orange extract, strawberry extract, safflower extract, gentianana extract, mint extract, green lily (spearmint) extract, mint mint (Peppermint) extract, Mukuroji extract, Kumazaza extract, Odorikosou extract, Avocado extract, Prunes extract, Lime extract, Tormentilla extract, Olive extract, Olive extract, Safflower extract, Jojoba extract, Macadamia nut extract, Medhu home extract, Oyster extract (oyster meat extract), hydrolyzed elastin, hydrolyzed keratin solution, hydrolyzed collagen, hydrolyzed silk, soluble collagen, vegetable collagen, quince Doekisu, grapefruit extract, lactic acid bacteria culture fluid, Bifidobacterium metabolites, rice power extract, and the like.

  One or more kinds of these humectants can be used, and 0.00001 to 50% by mass, particularly 0.0001 to 40% by mass, and further 0.0001 to 30% by mass are contained in the cosmetic (B). However, it is preferable because a sufficient moisturizing effect is obtained and the feeling of use and stability are excellent. However, when the active ingredient is an animal or plant extract, the dry solid content is used.

  The anti-inflammatory agent is not particularly limited as long as it is used in normal cosmetics. Examples of the compound include allantoin and dipotassium glycyrrhizinate. Examples of animal or plant extracts include licorice extract, mugwort. Extract, peony root extract, rosemary extract, gardenia extract, sage extract, toki extract (toki extract) and the like.

  One or more kinds of these anti-inflammatory agents can be used, and 0.00001 to 30% by mass, particularly 0.0001 to 20% by mass, and further 0.0001 to 10% by mass are contained in the cosmetic (B). This is preferable because a sufficient anti-inflammatory effect is obtained and the feeling of use and stability are excellent. However, when the active ingredient is an animal or plant extract, the dry solid content is used.

  Antioxidants are not particularly limited as long as they are used in ordinary cosmetics. Examples of compounds include astaxanthin, alpha lipoic acid, ergothioneine, carotenoids, carotenes, catechins, coenzyme Q10, fullerenes, and platinum nanocolloids. Examples of the animal or plant extract include wild rose extract, gentian pepper extract, honeysuckle extract, yukinoshita extract, oil-soluble licorice extract, mugwort leaf extract and the like.

  One or more kinds of these antioxidants can be used, and 0.00001 to 30% by mass, particularly 0.0001 to 20% by mass, and further 0.0001 to 10% by mass are contained in the cosmetic (B). This is preferable because a sufficient antioxidant effect can be obtained and the feeling of use and stability are excellent. However, when the active ingredient is an animal or plant extract, the dry solid content is used.

  The cell activator is not particularly limited as long as it is used in ordinary cosmetics. For example, examples of the compound include retinol, cyanocobalamin, riboflavin, niacinamide, etc .; Examples include extracts, soybean isoflavones, camellia extract, cypress extract, beech sprout extract, and Ibukizasou extract.

  One or more kinds of these cell activators can be used, and 0.00001 to 30% by mass, particularly 0.0001 to 20% by mass, and further 0.0001 to 10% by mass are contained in the cosmetic (B). This is preferable because a sufficient cell activation effect is obtained and the feeling of use and stability are excellent. However, when the active ingredient is an animal or plant extract, the dry solid content is used.

  The plant extract used in component (B) is, for example, a method of extracting leaves, roots, stems, flowers, etc. of these plants using water and / or a hydrophilic organic solvent to obtain an extract; Examples thereof include a method of obtaining a powder from such an extract by freeze drying, spray drying, vacuum distillation or the like. Examples of the hydrophilic organic solvent include methanol, ethanol, glycols and the like, and ethanol is particularly preferable. These solvents may be used alone or in combination of two or more thereof, or water and these hydrophilic organic solvents may be mixed and used. The amount of these extraction solvents to be used is not particularly limited, and the obtained extract can be used as it is or after further concentration and purification. Moreover, the commercial item of these plant extracts can also be used suitably.

[Cosmetics (C)]
The cosmetic (C) used in the present invention has a pH of 4.5 or more and less than 6. Adjustment of pH can be performed similarly to cosmetics (A) and (B). By setting this range, the skin barrier function can be returned to the normal state.

The cosmetic (C) can further contain acidic amino acids, cholesterols, ceramides, etc., and is more effective for restoring the skin barrier function and protecting the skin.
Examples of acidic amino acids include aspartic acid and glutamic acid.
One or more acidic amino acids can be used, and 0.0001 to 30% by mass, particularly 0.001 to 20% by mass in the cosmetic (C) restores the skin barrier function and improves the skin. It is preferable from the viewpoints of protection and usability and stability.

  Cholesterols include animal sterols such as cholesterol, cholestanol, lanosterol, selegrosterol, dehydrocholesterol, and cobrostanol; plant sterols such as phytosterol, β-sitosterol, stigmasterol, campesterol, and ergosterol; Steroids derived from microorganisms such as mycosterol and timosterol, and fatty acid esters and sterols of these sterols and fatty acids obtained by decomposing natural fats and oils such as oleic acid, palmitic acid, stearic acid, isostearic acid and olive oil Alkyl (alkenyl) ether derivatives in which the hydrogen atom of the hydroxyl group is substituted with an alkyl group or an alkenyl group, alkyl (alkenyl) esters substituted with an acyl group, glycosides substituted with a sugar residue, etc. Conductor and the like.

  One or more kinds of cholesterols can be used, and it is contained in the cosmetic (C) in an amount of 0.00001 to 30% by mass, particularly 0.0001 to 20% by mass to restore the skin barrier function. It is preferable from the viewpoints of protection and usability and stability.

  Examples of ceramides include those represented by the general formula (4).

(In the formula, R ⁴ represents a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 4 to 30 carbon atoms or a hydrogen atom, which may be substituted by a hydroxyl group, a carbonyl group or an amino group. Z represents a methylene group, a methine group or an oxygen atom; X ² , X ³ and X ⁴ each independently represent a hydrogen atom, a hydroxyl group or an acetoxy group, and X ¹ represents a hydrogen atom, an acetyl group or a glyceryl group; or shown, together with the adjacent oxygen atom, forms an oxo group (provided that when Z is a methine group, one of X ² and X ³ are hydrogen atoms, is .X ¹ the other is absent X ⁴ is not present when forming an oxo group.); R ⁵ and R ⁶ each independently represent a hydrogen atom, a hydroxyl group, a hydroxymethyl group or an acetoxymethyl group; R ⁷ is a hydroxyl group, a carbonyl group or A A linear, branched or cyclic saturated or unsaturated hydrocarbon group having 5 to 60 carbon atoms which may have an ether bond, ester bond or amide bond in the main chain, which may be substituted by a mino group R ⁸ represents a hydrogen atom, or may have a substituent selected from a hydroxyl group, a hydroxyalkoxy group, an alkoxy group and an acetoxy group, and is a straight chain or branched chain having 1 to 30 carbon atoms in total A saturated or unsaturated hydrocarbon group (provided that when R ⁴ is a hydrogen atom and Z is an oxygen atom, R ⁸ is a hydrocarbon group having 10 to 30 carbon atoms in total, and R ⁴ is a hydrocarbon group; ⁸ is a hydrocarbon group having 1 to 8 carbon atoms in total); the broken line indicates that it may be an unsaturated bond)

In the formula, R ⁴ is a linear group having 4 to 30 carbon atoms, preferably a hydroxyl group 7 to 22 carbon atoms which may be substituted by a hydroxyl group, a carbonyl group or an amino group, A branched or cyclic saturated or unsaturated hydrocarbon group or a hydrogen atom.
Z represents a methylene group, a methine group or an oxygen atom.

X ² , X ³ and X ⁴ each independently represent a hydrogen atom, a hydroxyl group or an acetoxy group. In particular, it is preferable that 0 to 1 of X ² , X ³ and X ⁴ is a hydroxyl group and the remainder is a hydrogen atom. When Z is a methine group, only one of X ² and X ³ is a hydrogen atom, and the other does not exist. X ¹ is preferably a hydrogen atom or a glyceryl group.
R ⁵ and R ⁶ represent a hydrogen atom, a hydroxyl group, a hydroxymethyl group or an acetoxymethyl group, preferred R ⁵ is a hydrogen atom or a hydroxymethyl group, and preferred R ⁶ is a hydrogen atom.

R ⁷ may be a hydroxyl group, a carboxy group or an amino group, may be substituted, and the main chain may have an ether bond, an ester bond or an amide bond, a straight chain having 5 to 60 carbon atoms, a branched chain or A cyclic saturated or unsaturated hydrocarbon group is shown. Preferably, the hydroxyl group or amino group may be substituted a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 5 to 35 carbon atoms, or a hydroxyl group at the ω position of the hydrocarbon group In which a linear, branched, or cyclic saturated or unsaturated fatty acid having 8 to 22 carbon atoms, which may be substituted, is an ester bond or an amide bond. As the fatty acid to be bonded, isostearic acid, 12-hydroxystearic acid or linoleic acid is preferable.

R ⁸ represents a hydrogen atom, or may have a substituent selected from a hydroxyl group, a hydroxyalkoxy group, an alkoxy group, and an acetoxy group. It is a saturated hydrocarbon group. In particular, when R ⁴ is a hydrogen atom and Z is an oxygen atom, R ⁸ is a hydrocarbon group having 10 to 30 carbon atoms in total. When R ⁴ is a hydrocarbon group, R ⁸ is a hydrocarbon group having 1 to 8 carbon atoms in total. Among these, a hydrogen atom or a hydrocarbon group having 1 to 8 carbon atoms in which 1 to 3 groups selected from a hydroxyl group, a hydroxyalkoxy group and an alkoxy group may be substituted is preferable. Here, as a hydroxy alkoxy group and an alkoxy group, a C1-C7 thing is preferable.

The ceramides represented by the general formula (4) are particularly preferably ceramides represented by the following general formula (5) or (6).
(I) Natural or natural ceramides represented by the general formula (5) and derivatives thereof (hereinafter referred to as natural ceramide).

(Wherein R ¹¹ represents a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 7 to 19 carbon atoms which may be substituted by a hydroxyl group; Z ₁ represents a methylene group or a methine group; X ⁵ , X ⁶ and X ⁷ each independently represents a hydrogen atom, a hydroxyl group or an acetoxy group; X ⁸ represents a hydrogen atom or together with an adjacent oxygen atom, forms an oxo group. (However, when Z ₁ is a methine group, _one of X ⁵ and X ⁶ is a hydrogen atom and the other does not exist. When X ⁸ forms an oxo group, X ⁷ does not exist.); R ¹² represents a hydroxymethyl group or an acetoxymethyl group; R ¹³ represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R ¹⁴ has 5 to 30 carbon atoms which may be substituted by a hydroxyl group Whether it is a linear, branched or cyclic saturated or unsaturated hydrocarbon group Or a linear or branched saturated or unsaturated fatty acid having 8 to 22 carbon atoms which may be substituted with a hydroxyl group at the ω-terminal of the alkyl group; Indicates that it may be a bond.)

Preferably, R ¹¹ is a linear alkyl group having 7 to 19 carbon atoms, more preferably 13 to 15 carbon atoms; R ¹⁴ is a linear alkyl group having 9 to 27 carbon atoms which may be substituted by a hydroxyl group or linole The compound which is a C9-C27 linear alkyl group which the acid ester-bonded is mentioned. X ⁸ preferably represents a hydrogen atom or forms an oxo group together with an oxygen atom. In particular, R ¹⁴ is preferably tricosyl, 1-hydroxypentadecyl, 1-hydroxytricosyl, heptadecyl, 1-hydroxyundecyl, or a nonacosyl group in which linoleic acid is ester-bonded to the ω position.

  Specific examples of natural ceramides include ceramides Type 1 to 7 in which sphingosine, dihydrosphingosine, phytosphingosine or sphingadienin is amidated (for example, J. Lipid Res., 24: 759 (1983), FIG. And porcine and human ceramides described in FIG. 4 of J. Lipid. Res., 35: 2069 (1994)).

Furthermore, these N-alkyl bodies (for example, N-methyl body) are also included.
These ceramides may be either natural (D (−)) optically active or non-natural (L (+)) optically active, or a mixture of natural and nonnatural. May be used. The relative configuration of the above compound may be a natural configuration, a non-natural configuration other than that, or a mixture thereof. In particular, compounds of CERAMIDE1, CERAMIDE2, CERAMIDE3, CERAMIDE5, CERAMIDE6II (above, INCI, 8th Edition) and those represented by the following formula are preferable.

These may be any of natural extracts and synthetic products, and commercially available products can be used.
Such commercially available natural ceramides are Ceramide I, Ceramide III, Ceramide IIIA, Ceramide IIIB, Ceramide IIIC, Ceramide VI (above, Cosmo Farm), Ceramide TIC-001 (Takasago Inc.), CERAMIDE II (Quest International), DS-Ceramide VI, DS-CLA-Phytoceramide, C6-Phytoceramide, DS-ceramide Y3S (above, DOOSAN), CERAMIDE2 (Cedama).

(II) A pseudo-ceramide represented by the general formula (6).

(In the formula, R ¹⁵ represents a linear, branched or cyclic saturated or unsaturated hydrocarbon group or a hydrogen atom having 10 to 22 carbon atoms which may be substituted with a hydroxyl group; X ⁹ represents a hydrogen atom; , An acetyl group or a glyceryl group; R ¹⁶ is a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 5 to 22 carbon atoms which may be substituted with a hydroxyl group or an amino group; Or a hydrocarbon group having an ester bond with a linear or branched saturated or unsaturated fatty acid having 8 to 22 carbon atoms which may be substituted with a hydroxyl group at the ω-terminal; R ¹⁷ represents a hydrogen atom; Or a hydroxyl group, a hydroxyalkoxy group, an alkoxy group or an acetoxy group which may be substituted represents a C1-C30 alkyl group)

R ¹⁶ is particularly nonyl, tridecyl, pentadecyl, an undecyl group in which linoleic acid is ester-bonded to the ω position, a pentadecyl group in which linoleic acid is ester-bonded to the ω position, and a pentadecyl group in which 12-hydroxystearic acid is ester-bonded to the ω position. An undecyl group in which methyl branched isostearic acid is amide-bonded at the ω position is preferred.

R ¹⁷ is an alkyl having a total carbon number of 10 to 30, preferably a total carbon number of 12 to 20, which may be substituted by a hydroxyl group, a hydroxyalkoxy group, an alkoxy group or an acetoxy group when R ¹⁵ is a hydrogen atom. When R ¹⁵ is a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 10 to 22 carbon atoms which may be substituted with a hydroxyl group, What shows a C1-C8 alkyl group which the hydroxyl group, the hydroxy alkoxy group, an alkoxy group, or an acetoxy group may substitute is preferable. The hydroxyalkoxy group or alkoxy group for R ¹⁷ is preferably one having 1 to 7 carbon atoms.

In general formula (6), R ¹⁵ is a hexadecyl group, X ⁹ is a hydrogen atom, R ¹⁶ is a pentadecyl group, R ¹⁷ is a hydroxyethyl group; R ¹⁵ is a hexadecyl group, X ⁹ is a hydrogen atom, and R ¹⁶ is R ¹⁶ Preferred are pseudoceramides having a nonyl group, R ¹⁷ is a hydroxyethyl group; or R ¹⁵ is a hexadecyl group, X ⁹ is a glyceryl group, R ¹⁶ is a tridecyl group, and R ¹⁷ is a 3-methoxypropyl group. Particularly preferred is 6) wherein R ¹⁵ is a hexadecyl group, X ⁹ is a hydrogen atom, R ¹⁶ is a pentadecyl group, and R ¹⁷ is a hydroxyethyl group.

  One or more ceramides can be used, and the content of 0.00001 to 30% by mass, especially 0.0001 to 20% by mass in the cosmetic (C) restores the barrier function and protects the skin. In addition, it is preferable from the viewpoint of usability and stability.

In cosmetics (A), (B) and (C), in addition to the above components, components used in ordinary cosmetics, such as oily components, surfactants, thickeners, powders, refreshing agents, antioxidants Agents, preservatives, fragrances, bactericides, pigments, UV absorbers, heat generators, coolants, and the like can be included.
Moreover, cosmetics (A) can also contain the active ingredient contained in cosmetics (B).

  The cosmetics (A), (B), and (C) can be produced by a usual method, and each is preferably an aqueous cosmetic having an appropriate dosage form. For example, a lotion, a cosmetic liquid, a gel, an emulsion, a cream, a solid stick, a pack, an impregnation mask, a mist, a foundation, a foam, a spray, and the like can be used. In particular, it is preferable that (A) is a lotion, (B) is a cosmetic liquid, (C) is a milky lotion, and a cream.

  In the present invention, the cosmetic (A) is used first, then the cosmetic (B) is used, and further the cosmetic (C) is used. The cosmetic (A) can make the environment in which the active ingredient can easily penetrate into the skin. By applying the cosmetic (B) to the skin in such a state, the active ingredient is effectively penetrated, and then By applying the cosmetic (C), the barrier function of the skin can be returned to the normal state, and the skin can be protected.

More specifically, the cosmetic (A) is applied to the skin, fully blended, and after remaining on the surface (after standing for about 1 to 5 minutes), the cosmetic (B) is applied. . Thereafter, the cosmetic (C) is applied and used in the same manner.
In this case, as the cosmetic (B), two or more kinds of cosmetics containing different active ingredients can be used.

  In the present invention, the pH of the cosmetic (A) and the cosmetic (B) may be the same or different, and the cosmetic (A) and the cosmetic (C) have a pH difference of 1 or more. Is preferable because it restores the barrier function of the skin and protects the skin.

The cosmetics (A), (B) and (C) used in the present invention can be a cosmetic kit for use as described above.
Further, the cosmetics (A), (B) and (C) can be described in the leaflet to be used as described above.

Example 1
(1) Drug penetration:
The pig skin was lightly washed with a neutral detergent (about 1 minute) to sufficiently remove sebum adhering to the skin surface, and the initial state was made uniform.
Pig skin was sandwiched between diffusion cells, and cosmetic (A) shown in Table 1 was applied to the surface of the pig skin at 100 μg / cm ² and left for 3 hours (temperature 25 ° C., humidity 40%). After 3 hours, the cosmetic (A) on the surface of the pig skin was washed with water to remove the cosmetic (A) remaining on the surface. Next, using a cosmetic (B) (Table 2) containing 0.01% by weight of a fluorescent dye (acridine orange; AO) as an indicator of penetration of the components, 100 μg / cm ^{2 was} applied to the same site for 3 hours. (Temperature 25 ° C., humidity 40%). Thereafter, the cosmetic (B) was removed from the surface of the pig skin by washing with water, and then the skin treated with each cosmetic was cut out with BIOPSY PUNCH, and the horny layer and the epidermis were peeled off with a razor. AO penetrating into the stratum corneum and epidermis was extracted with a 55% ethanol solution, and quantified with a spectrofluorometer (Hitachi, F-7000). The quantitative value was shown in terms of the amount of permeation per cm ² .

  From the results of Table 3, as in Nos. 1 to 3, cosmetics (A) and (B) having a pH of 6 to 8.5 are combined and subjected to immersion treatment, so that at least one of the cosmetics has a pH of less than 6. No. combining Compared with 4-6, the penetration amount of AO was excellent.

(2) Recovery of skin barrier ability:
The pig skin was lightly washed with a neutral detergent (about 1 minute) to sufficiently remove sebum adhering to the skin surface, and the initial state was made uniform.
Pig skin was sandwiched between diffusion cells, and cosmetic (A) (Table 1) was applied to the surface of the pig skin at 100 μg / cm ² and left for 3 hours (temperature 25 ° C., humidity 40%). After 3 hours, the cosmetic (A) on the surface of the pig skin was washed with water to remove the cosmetic (A) remaining on the surface. Next, the same part was immersed for 3 hours using cosmetic (B) (Table 2). After removing the cosmetic (B), using the cosmetic (C) (Table 4) containing 0.01% by mass of a fluorescent dye (acridine orange; AO) as an indicator of penetration of the ingredients, 100 μg is further added to the same site. / Cm ^{2 was} applied and left for 3 hours (temperature 25 ° C., humidity 40%). Thereafter, the cosmetic (C) was removed from the surface of the pig skin by washing with water, and then the skin treated with each cosmetic was cut out with BIOPSY PUNCH, and the horny layer and the epidermis were peeled off with a razor. AO penetrating into the stratum corneum and epidermis was extracted with a 55% ethanol solution, and quantified with a spectrofluorometer (Hitachi, F-7000). The quantitative value was shown in terms of the amount of permeation per cm ² .

  From the results of Table 5, as in Nos. 7 to 10, by immersing the cosmetics (A) and (B) in combination with the cosmetics (C) having a pH of less than 4.5 to 6, the pH is 6.8. As compared with No. 11 to 12 using the cosmetic C-3, recovery of the skin barrier ability was recognized because the penetration amount of AO was low.

Example 2
(Cosmetics A)
(Ingredient) (mass%)
Ethanol 3.0
Adipic acid 0.01
Methylparaben 0.2
Sodium dihydrogen phosphate 0.36
Sodium monohydrogen phosphate 0.29
Succinic acid 2- (2-hydroxyethoxy) ethylguanidine 0.5
N-amidino-L-proline 0.4
Trimethylglycine 0.2
Glycerin 5.0
Polyoxyethylene / methylpolysiloxane copolymer 0.1
Maronie extract (manufactured by Maruzen Pharmaceutical Co., Ltd., Maronie extract, solid content: 1.0%) 1.0
Eucalyptus extract (Maruzen Pharmaceutical Co., Ltd., Eucalyptus extract BG-KA, solid content: 0.2%)
0.8
Water-soluble ginger extract (manufactured by Tianjin Pacific Pharmaceutical Co., Ltd., gyoza SP, solid content: 8.0%) 1.0
Purified water balance (pH 6.5)

(Cosmetics B)
(Ingredient) (mass%)
Water-soluble ginger extract (manufactured by Tianjin Pacific Pharmaceutical Co., Ltd., gyoza SP, solid content: 8.0%) 1.0
Maronnier extract (manufactured by Maruzen Pharmaceutical Co., Ltd., Maronnier extract, solid content: 1.0%) 2.0
Chamomile extract (manufactured by Maruzen Pharmaceutical Co., Ltd., trade name: Chamomile KSQ, solid content: 0.4%) 0.5
N-amidino-L-proline 3.0
Carboxyvinyl polymer 0.45
Succinic acid 0.29
Potassium hydroxide 0.58
Glycerin 10.0
2- (2-hydroxyethoxy) ethylguanidine succinate 1.0
Methyl paraoxybenzoate 0.2
1- (2-hydroxyethylamino) -3-isostearyloxy-2-propanol 0.2
Xanthan gum 0.1
Polyoxyethylene hydrogenated castor oil 0.5
Purified water balance (pH 7.0)

(Cosmetic C)
(Ingredient) (mass%)
1- (2-hydroxyethylamino) -3-isostearyloxy-2-propanol 0.1
N- (hexadecyloxyhydroxypropyl) -N-hydroxyethylhexadecanamide 2.0
Long-chain dibasic acid bis 3-methoxypropylamide 0.0001
L-glutamic acid 0.034
Cetanol 0.39
Stearyl alcohol 0.26
Methylpolysiloxane 5.0
Glycerin 3.0
Asunaro extract (manufactured by Ichimaru Falcos, Asnarolo Liquid K, solid content: 0.25%) 1.0
Cholesterol 0.001
Purified water balance (pH 5.0)

Example 3
(Cosmetics A)
(Ingredient) (mass%)
Dipropylene glycol 2.0
Glycerin 11.0
Methyl paraoxybenzoate 0.2
N-amidino-L-proline 0.4
Succinic acid 2- (2-hydroxyethoxy) ethylguanidine 0.5
Trimethylglycine 2.0
Sodium dihydrogen phosphate 0.36
Sodium monohydrogen phosphate 0.29
Polyoxyethylene methyl glucoside 1.0
Dimethylsiloxane methyl (undecyl glyceryl ether)
Siloxane copolymer 0.12
Polyoxyethylene isocetyl ether (20E.O.) 0.2
Methyl polysiloxane 0.01
Yuzu extract (manufactured by Maruzen Pharmaceutical Co., Ltd., Yuzu extract, solid content: 1.2%) 1.0
Purified water balance (pH 6.6)

(Cosmetics B)
(Ingredient) (mass%)
Water-soluble ginger extract (manufactured by Tianjin Pacific Pharmaceutical Co., Ltd., gyoza SP, solid content: 8.0%) 1.0
Yuzu extract (manufactured by Maruzen Pharmaceutical Co., Ltd., Yuzu extract, solid content: 1.2%) 0.5
N-amidino-L-proline 3.0
Carboxyvinyl polymer 0.45
Succinic acid 0.29
Potassium hydroxide 0.58
1,3-butylene glycol 5.0
2- (2-hydroxyethoxy) ethylguanidine succinate 1.0
Methyl paraoxybenzoate 0.2
1- (2-hydroxyethylamino) -3-isostearyloxy-2-propanol 0.2
Hydroxyethyl cellulose 0.1
Polyoxyethylene hydrogenated castor oil 0.5
Purified water balance (pH 6.9)

(Cosmetic C)
(Ingredient) (mass%)
1- (2-hydroxyethylamino) -3-isostearyloxy-2-propanol 0.1
N- (hexadecyloxyhydroxypropyl) -N-hydroxyethylhexadecanamide 2.0
Long-chain dibasic acid bis 3-methoxypropylamide 0.0001
L-glutamic acid 0.034
Cetanol 0.39
Stearyl alcohol 0.26
Methylpolysiloxane 5.0
Propylene glycol 3.0
Seaweed extract (Ichimaru Falcos, Falco Rex Hibamata EX,
(Solid content: 1.5%) 1.0
Eucalyptus extract (Maruzen Pharmaceutical Co., Ltd., Eucalyptus extract BG-KA, solid content: 0.2%)
0.5
Cholesterol 0.001
Purified water balance (pH 5.0)

Example 4
(Cosmetics A)
(Ingredient) (mass%)
Glycerin 10.0
Methyl paraoxybenzoate 0.2
N-amidino-L-proline 0.4
Succinic acid 2- (2-hydroxyethoxy) ethylguanidine 0.5
Sodium dihydrogen phosphate 0.36
Sodium monohydrogen phosphate 0.29
Polyethylene glycol 1540 2.0
Sodium hyaluronate 0.001
1- (2-hydroxyethylamino) -3-isostearyloxy-2-propanol 0.001
Polyoxyethylene octyldodecyl ether 0.3
Alkyl-1,3-dimethylbutyl ether 0.1
Squalane 0.1
Water-soluble ginger extract (manufactured by Tianjin Pacific Pharmaceutical Co., Ltd., gyoza SP, solid content: 8.0%) 1.0
Purified water balance (pH 6.4)

(Cosmetics B)
(Ingredient) (mass%)
Water-soluble ginger extract (manufactured by Tianjin Pacific Pharmaceutical Co., Ltd., gyoza SP, solid content: 8.0%) 1.0
Yeast extract (manufactured by Silab, TONISKIN, solid content: 3.6%) 0.1
Lemon extract (Ichimaru Falcos, Lemon Extra Liquid K,
(Solid content: 0.65%) 0.1
N-amidino-L-proline 3.0
Carboxyvinyl polymer 0.45
Succinic acid 0.29
Potassium hydroxide 0.58
1,3-butylene glycol 5.0
2- (2-hydroxyethoxy) ethylguanidine succinate 1.0
Methyl paraoxybenzoate 0.2
1- (2-hydroxyethylamino) -3-isostearyloxy-2-propanol 0.2
Xanthan gum 0.1
Polyoxyethylene hydrogenated castor oil 0.5
Purified water balance (pH 6.9)

(Cosmetic C)
(Ingredient) (mass%)
1- (2-hydroxyethylamino) -3-isostearyloxy-2-propanol 0.15
N- (hexadecyloxyhydroxypropyl) -N-hydroxyethylhexadecanamide 4.0
L-glutamic acid 0.04
Cetanol 0.7
Stearyl alcohol 0.4
Methylpolysiloxane 5.0
Dipropylene glycol 3.0
Glycerin 5.0
Yuzu extract (manufactured by Maruzen Pharmaceutical Co., Ltd., Yuzu extract, solid content: 1.2%) 1.0
Eucalyptus extract (Maruzen Pharmaceutical Co., Ltd., Eucalyptus extract BG-KA, solid content: 0.2%)
0.5
Cholesterol 0.001
Purified water balance (pH 4.8)

  In Examples 2 to 4, the cosmetic (A) was first used, and then the cosmetic (B) was used to effectively penetrate the active ingredient contained in the cosmetic (B). This was a useful method for restoring the barrier function of the skin by using the cosmetic (C).

Claims (4)

The following cosmetics (A), (B), and (C):
(A) Cosmetics containing 0.03 to 8% by mass of a component selected from phosphoric acid and its salt and succinic acid and its salt, and having a pH of 6 to 8.5,
(B) 0.03-8 mass% component selected from succinic acid and its salt, pH 6-8.5, whitening agent, wrinkle improver, ceramide production promoter, blood circulation promoter, moisturizer, Cosmetics containing one or more active ingredients selected from anti-inflammatory agents, antioxidants and cell activators,
(C) Acidic amino acids 0.001-20% by mass, cholesterols 0.0001-20% by mass and ceramides 0.0001-20% by mass Cosmetics,
A cosmetic method using the cosmetic (A), the cosmetic (B), and then the cosmetic (C).   The cosmetic method according to claim 1, wherein the cosmetic (A) contains guanidines.   The cosmetic method according to claim 1 or 2, wherein there is at least one difference in pH between the cosmetic (A) and the cosmetic (C). The following cosmetics (A), (B), and (C):
(A) Cosmetics containing 0.03 to 8% by mass of a component selected from phosphoric acid and its salt and succinic acid and its salt, and having a pH of 6 to 8.5,
(B) 0.03-8 mass% component selected from succinic acid and its salt, pH 6-8.5, whitening agent, wrinkle improver, ceramide production promoter, blood circulation promoter, moisturizer, Cosmetics containing one or more active ingredients selected from anti-inflammatory agents, antioxidants and cell activators,
(C) Acidic amino acids 0.001-20% by mass, cholesterols 0.0001-20% by mass and ceramides 0.0001-20% by mass Cosmetics,
A cosmetic kit for first using the cosmetic (A), using the cosmetic (B), and further using the cosmetic (C).