JP5665604B2 - Piping line filter switching method and apparatus - Google Patents

Description

  The present invention relates to a filter switching method and apparatus provided for the purpose of removing foreign matter in the middle of a piping line for sending liquid aseptically to a filling machine or the like.

Conventionally, about switching of the filter provided in the middle of the piping line, the piping is branched in parallel, each is provided with a filter, and one of them is used, and the other is cleaned to remove clogging due to foreign matter. more example switching of a filter alternately use, efficiency improvement of productivity has been achieved. (Patent Document 1)

Japanese Patent Laid-Open No. 64-5563 (FIG. 1)

In recent years, containers such as food liquids and pharmaceutical liquids have been aseptically filled into containers, and the filter provided in the middle of a piping line that delivers liquids aseptically to filling machines or the like has become clogged. to without stopping the filling machine, were re-sterilization during filter switching example efficiently, there is an increasing demand for a so as to increase productivity.

  According to the above-mentioned Patent Document 1, in the unwanted matter removing apparatus for separating and removing unwanted matter (foreign matter) in blood used in the continuous salting-out plasma processing system, two (plural) unwanted matter removing filters (here, Are simply arranged in parallel, and the blood is introduced into one of the filters to remove unnecessary substances, and the other is a filter that is washed or replaced to remove clogging. Alternate use.

  However, in the case where it is necessary to separate and remove unnecessary substances from the blood in an aseptic condition, the technique disclosed in Patent Document 1 releases the aseptic condition when cleaning or replacing a filter clogged with unnecessary substances. When trying to continue the operation, it is necessary to re-sterilize the entire line including the filter through which the blood of the plasma processing system flows, so that the productivity is deteriorated. When the filter is manually cleaned or replaced, the liquid remaining in the filter at the time of opening the filter and having a pressure higher than the atmospheric pressure is ejected, which may be dangerous.

The present invention relates to a method and an apparatus for switching a filter provided in the middle of a piping line for sending a liquid in an aseptic condition, while maintaining the upstream and downstream piping lines of the filter unit to be switched in a sterile condition. the filter as cut with washing or replacement, plurality without stopping the at least one row of liquid feed parallel branched pipe line, i.e., without stopping the feeding destination of the filling machine, to improve the productivity Filter switching method and device, filter switching method and device that can efficiently re-sterilize the piping line after filter cleaning or replacement , and filter can be safely cleaned or replaced when the filter is manually switched An object is to provide a filter switching method and apparatus.

The present invention solves the above problems by the following means.
(1) The filter switching method for the piping line of the first means is as follows:
In a method for switching a filter provided in the middle of a piping line for sending liquid in an aseptic condition, an on-off valve (A) provided on the upstream side of the filter on the piping line and an on-off valve provided on the downstream side of the filter ( F) is closed, and after draining the liquid remaining between the on-off valve (A) and the on-off valve (F), between the filter and the on-off valve (A) and between the filter and the on-off valve (F ) Between the opening / closing valve (A) and the opening / closing valve (B) and between the opening / closing valve (E) and the opening / closing valve (F). ) Between the pipes of the sterilization means such as steam and the open connection state by means of the open / close valve, and the sterilization barrier zone (ST1) and the sterilization barrier zone (ST2) by the steam etc., respectively, upstream of the open / close valve (A) And under the on-off valve (F) While holding the side of the pipeline in a sterile condition, wherein the replacing or cleaning the filter.

(2) The pipe line filter switching method of the second means is the same as the filter switching method of the pipe line of the first means, between the filter and the on-off valve (B) of the pipe line and the filter and on-off valve. Further, the on-off valve (C) and the on-off valve (D) further provided during (E) are closed, and between the on-off valve (B) and the on-off valve (C) and between the on-off valve (D) and on / off. The on-off valve (C) is formed as an aseptic air zone (AS1) and an aseptic air zone (AS2) in which the valve (E) is opened by an open / close valve with a sterile air supply pipe, and is positively pressurized with sterile air. The filter is exchanged or washed in a non-high temperature state in a zone adjacent to the section of the on-off valve (D).

(3) A pipe line filter switching method of the third means is a method of switching a filter provided in the middle of a pipe line for sending a liquid in an aseptic state, and is an opening / closing provided on the upstream side of the filter of the pipe line. After closing the valve (A) and the on-off valve (F) provided on the downstream side of the filter and draining the liquid remaining between the on-off valve (A) and the on-off valve (F), the filter The on-off valve (B) and the on-off valve (E) provided between the filter and the on-off valve (F) are closed, and the on-off valve (A) and the on-off valve ( B) and between the on-off valve (E) and the on-off valve (F) are opened and connected by the on-off valves with the sterilized air supply pipes, respectively, and the sterilized air zones (AS3) are brought into a positive pressure state with sterilized air. And sterile air zone As AS4), the on-off valve (C) and the on-off valve (D) provided between the filter and the on-off valve (B) and between the filter and the on-off valve (E) of the piping line are closed. Thus, the open / close valve (B) and the open / close valve (C) and the open / close valve (D) and the open / close valve (E) are connected to each other by open / close valves connected to piping of sterilization means such as steam. As the sterilization barrier zone (ST3) and the sterilization barrier zone (ST4) by steam, etc., the piping lines upstream of the on-off valve (A) and downstream of the on-off valve (F) are maintained in a sterile state. The filter is replaced or washed .

(4) The filter switching method for the piping line of the fourth means is the same as the filter switching method for the piping line of the third means, between the filter and the opening / closing valve (C) of the piping line and the filter and the opening / closing valve. Further, the on-off valve (G) and the on-off valve (H), which are further provided during (D), are closed, and between the on-off valve (C) and the on-off valve (G) and the on-off valve (H). The valve (D) is opened and closed with an open / close valve connected to the sterile air supply pipe, and the open / close valve (G5) is set as a sterile air zone (AS5) and a sterile air zone (AS6) that are positively pressurized with sterile air. ) And the on-off valve (H) section adjacent to the zone is replaced or washed in a non-high temperature state.

(5) The filter switching method for the piping line of the fifth means is the same as the filter switching method for the piping line of the first, second, third or fourth means. ) And the on-off valve (E), or between the on-off valve (C) and the on-off valve (D), or between the on-off valve (C) and the on-off valve (D), or The filter is cleaned by performing stationary cleaning between the on-off valve (H) as an open connection state with an on-off valve with a stationary cleaning liquid supply pipe.

(6) The pipe line filter switching method of the sixth means is the pipe line filter switching method of the fifth means, wherein the stationary cleaning liquid is sent in a direction opposite to the liquid feeding direction of the pipe line. Then, the filter is back-washed.

(7) Filter switching method of the pipe line of the seventh means, in the filter switching method of a pipe line of said fifth and sixth means, to automatically wash not remove the front notated Iruta from the pipeline Features.

(8) filter switching method of the pipe line of the eighth means, in the filter switching method of the pipe line of the seventh means from the fifth, after the cleaning in place before notated Iruta, the on-off valve (A) and Between the on-off valve (F), an open / close valve is connected to the pipe of the sterilization means such as steam, and the sterilization is performed under a predetermined condition (temperature, time, etc.) with steam or the like. After sterilization, it is characterized in that it is cooled by sterilized air blowing in an open connection state with an open / close valve with a sterile air supply pipe.

(9) The filter switching method for the piping line of the ninth means is the same as the filter switching method for the piping line of the eighth means, wherein the sterile air is placed between the on-off valve (A) and the on-off valve (F). It is characterized in that it is kept in a positive pressure state with aseptic air after cooling with air blowing.

(10) The pipe line filter switching method of the tenth means is the pipe line filter switching method of the first and fifth to ninth means, wherein each of the pipe lines is branched into a plurality of rows. The branch pipe is provided with a filter, an on-off valve (A), an on-off valve (B), an on-off valve (E), an on-off valve (F), a sterilization barrier zone (ST1), and a sterilization barrier zone (ST2). Stop liquid supply from the upstream side to the downstream side of the piping line by supplying liquid in aseptic condition in a row or a partial row and replacing or cleaning the remaining filter in the other row. Without replacing or cleaning the filter in the other row while keeping the piping line upstream of the on-off valve (A) and downstream of the on-off valve (F) of the branch pipe in the other row in a sterile state. To do And features.

(11) The pipe line filter switching method of the eleventh means is the pipe line filter switching method of the second and fifth to ninth means, wherein each of the branch pipes branching the pipe line into a plurality of rows. , Said filter, on-off valve (A), on-off valve (B), on-off valve (C), on-off valve (D), on-off valve (E), on-off valve (F), sterilization barrier zone (ST1) and sterilization barrier zone (ST2), a sterile air zone (AS1) and a sterile air zone (AS2) are provided, the liquid is sent in a sterile state in one or a part of the branch pipes, and the remaining filters in the other rows are exchanged or washed. Thus, the upstream side of the on-off valve (A) and the on-off valve (F) of the branch pipe in the other row without stopping the feeding of the liquid from the upstream side to the downstream side of the pipe line. Downstream of Still holding the pipe line in a sterile condition, to replace or clean the filter of the other row adjacent zone of the other row of the on-off valve (C) and the on-off valve (D) segment in a non-high temperature state Features.

(12) A pipe line filter switching method of the twelfth means is the pipe line filter switching method of the third and fifth to ninth means, wherein each of the pipe lines is branched into a plurality of rows. The filter, the on-off valve (A), the on-off valve (B), the on-off valve (C), the on-off valve (D), the on-off valve (E), the on-off valve (F), the aseptic air zone (AS3) and the aseptic air zone (AS4). ), A sterilization barrier zone (ST3), and a sterilization barrier zone (ST4), liquid is sent in aseptic condition in one or a part of the branch pipes, and the other filters in the other lines are exchanged or washed. Thus, the upstream side of the on-off valve (A) and the on-off valve (F) of the branch pipe in the other row without stopping the feeding of the liquid from the upstream side to the downstream side of the pipe line. Downstream of The pipeline remains held in sterile conditions, characterized in that to replace or clean the filter of the other columns.

(13) The pipe line filter switching method of the thirteenth means is the pipe line filter switching method of the fourth and fifth to ninth means, wherein each of the pipe lines is branched into a plurality of rows. The above-mentioned filter, on-off valve (A), on-off valve (B), on-off valve (C), on-off valve (G), on-off valve (H), on-off valve (D), on-off valve (E), on-off valve (F ), A sterile air zone (AS3), a sterile air zone (AS4), a sterilization barrier zone (ST3) and a sterilization barrier zone (ST4), and further a sterile air zone (AS5) and a sterile air zone (AS6). or feeding a liquid under sterile conditions in some columns, so as to replace or clean the filter of the remaining other columns, stop the liquid feed of the liquid from the upstream side to the downstream side of the pipe line Rukoto without the said on-off valve of the branch pipe of the other columns remain holding the downstream side of the pipeline in a sterile condition of the upstream and the on-off valve (A) (F), the on-off valve of the other row ( G) and the on-off valve (H) are adjacent to each other in a zone where the filter in the other row is replaced or washed in a non-high temperature state.

(14) A filter switching device for a piping line of a fourteenth means is a device for switching a filter provided in the middle of a piping line for sending a liquid in an aseptic state, wherein the filter is connected to the piping line upstream and downstream of the filter. An on-off valve (A) and an on-off valve (F) are provided, and an on-off connection mechanism with a drain pipe is provided so that the liquid remaining between the on-off valve (A) and the on-off valve (F) can be drained. And an on-off valve (B) and an on-off valve (E) are provided between the filter and the on-off valve (F), respectively, and the on-off valve (A) By providing an open / close connection mechanism between the open / close valve (B) and between the open / close valve (E) and the open / close valve (F) with the piping of the sterilization means such as steam, a sterilization barrier zone for steam or the like can be obtained. Configuration to the downstream side of the pipeline upstream and the on-off valve of the on-off valve (A) (F) remain kept in sterile conditions, characterized in that to be able to exchange or clean the filter.

(15) The filter switching device for the piping line of the fifteenth means is the filter switching device for the piping line of the fourteenth means, between the filter and the on-off valve (B) and between the filter and the on-off valve (E). An on-off valve (C) and an on-off valve (D) are provided between the on-off valve (B) and the on-off valve (C) and between the on-off valve (D) and the on-off valve (E). By providing an open / close connection mechanism with the supply pipe, each is configured as a positive pressure aseptic air zone, and the adjacent zone in the section between the open / close valve (C) and the open / close valve (D) is replaced with a non-high temperature state or It is characterized in that it can be cleaned .

(16) A filter switching device for a piping line of a sixteenth means is a device for switching a filter provided in the middle of a piping line for sending a liquid in an aseptic state, wherein the filter is connected to the piping line upstream and downstream of the filter. An on-off valve (A) and an on-off valve (F) are provided to open and close the drain pipe so that the liquid remaining between the on-off valve (A) and the on-off valve (F) can be drained. A mechanism is provided, and an on-off valve (B) and an on-off valve (E) are provided between the filter and the on-off valve (A) and between the filter and the on-off valve (F), respectively. ) And the on-off valve (B) and between the on-off valve (E) and the on-off valve (F) are provided with an open / close connection mechanism to the sterilized air supply pipe, respectively, so as to form a positive pressure aseptic air zone. Further, an on-off valve (C) and an on-off valve (D) are provided between the filter and the on-off valve (B) and between the filter and the on-off valve (E), respectively. (C) and between the on-off valve (D) and the on-off valve (E) are provided as an open / close connection mechanism with a pipe of sterilization means such as steam, respectively, thereby constituting a sterilization barrier zone for steam or the like. The filter can be replaced or cleaned while the piping lines upstream of the on-off valve (A) and downstream of the on-off valve (F) are maintained in a sterile state.

(17) The pipe line filter switching device of the seventeenth means is the filter switching device of the pipe line of the sixteenth means, between the filter and the on-off valve (C) of the pipe line and the filter and on-off valve. (D) is provided with an on-off valve (G) and an on-off valve (H), respectively, between the on-off valve (C) and the on-off valve (G) and between the on-off valve (H) and the on-off valve (D). By providing an open / close connection mechanism with a sterile air supply pipe between each, it is configured as a positive pressure sterile air zone, and the adjacent zone between the open / close valve (G) and the open / close valve (H) is in a non-high temperature state. The filter can be exchanged or washed .

(18) The pipe line filter switching device of the eighteenth means is the pipe line filter switching device of the seventeenth means, between the on-off valve (B) and the on-off valve (E) immediately before and after the filter, Alternatively, a stationary cleaning liquid between the on-off valve (C) and the on-off valve (D), between the on-off valve (C) and the on-off valve (D), or between the on-off valve (G) and the on-off valve (H). As a configuration provided with an open / close connection mechanism with a supply pipe, the filter can be automatically cleaned.

(19) The pipe line filter switching device of the nineteenth means is the pipe line filter switching device of the fourteenth and eighteenth means, wherein the pipe lines are branched into a plurality of rows, and the branched pipes are branched. In addition, the filter, the on-off valve (A), the on-off valve (B), the on-off valve (E), the on-off valve (F), and the drain that drains the liquid remaining between the on-off valve (A) and the on-off valve (F). An opening / closing connection mechanism for piping, the sterilization barrier zone is provided between the on-off valve (A) and the on-off valve (B) and between the on-off valve (E) and the on-off valve (F). The liquid is sent aseptically in one or a part of the piping, and the remaining other rows of the filter can be exchanged or washed, so that the liquid is sent from the upstream side to the downstream side of the piping line. without having to stop the, before the other columns Upstream and remains holding the downstream side of the pipe line of the on-off valve (F) in a sterile condition, characterized in that to be able to exchange or clean the filter of the other row of the on-off valve of the branch pipe (A) And

(20) The pipe line filter switching device of the twentieth means is the pipe line filter switching device of the fifteenth and eighteenth means, wherein the piping lines are branched into a plurality of rows, and the branched pipes are branched. In addition, the filter, on-off valve (A), on-off valve (B), on-off valve (C), on-off valve (D), on-off valve (E), on-off valve (F), on-off valve (A) and on-off valve ( F) an open / close connection mechanism with a drain pipe for draining liquid remaining between the open / close valve (A) and the open / close valve (B) and between the open / close valve (E) and the open / close valve (F). In the sterilization barrier zone, the aseptic air zone is provided between the on-off valve (B) and the on-off valve (C) and between the on-off valve (D) and the on-off valve (E). The liquid is sent aseptically in one or a part of the Other column said as filter exchange or cleaning of the from the upstream side of the pipe line without stopping the liquid feed of the liquid to the downstream side, the other row of the branch pipes of the on-off valve (A) And the adjacent zone in the section between the on-off valve (C) and the on-off valve (D) is kept in a non-high temperature state while the piping line on the upstream side of the on-off valve and the downstream side of the on-off valve (F) is maintained in a sterile state . The filter can be exchanged or washed .

(21) The pipe line filter switching device of the twenty-first means is the pipe line filter switching device of the sixteenth and eighteenth means, wherein the piping line is branched into a plurality of rows, and each of the branched pipes branched. In addition, the filter, on-off valve (A), on-off valve (B), on-off valve (C), on-off valve (D), on-off valve (E), on-off valve (F), on-off valve (A) and on-off valve ( F) an open / close connection mechanism with a drain pipe for draining liquid remaining between the open / close valve (A) and the open / close valve (B) and between the open / close valve (E) and the open / close valve (F). In the aseptic air zone, the sterilization barrier zone is provided between the on-off valve (B) and the on-off valve (C) and between the on-off valve (D) and the on-off valve (E). Deliver the liquid in aseptic conditions in a row or partial row, and the rest And can be exchanged or cleaned the filter column, the from the upstream side of the pipe line without stopping the liquid feed of the liquid to the downstream side, upstream of the other row of the branch pipes of the on-off valve (A) The filter in the other row can be replaced or cleaned while the piping line on the side and the downstream side of the on-off valve (F) is maintained in a sterile state.

(22) The pipe line filter switching device of the twenty-second means is the pipe line filter switching device of the seventeenth and eighteenth means, wherein the pipe line is branched into a plurality of rows, and each branched pipe is branched. In addition, the filter, on-off valve (A), on-off valve (B), on-off valve (C), on-off valve (G), on-off valve (H), on-off valve (D), on-off valve (E), on-off valve ( F), an on-off connection mechanism with a drain pipe for draining liquid remaining between the on-off valve (A) and the on-off valve (F), between the on-off valve (A) and the on-off valve (B) and the on-off valve ( E) between the on-off valve (F) and the aseptic air zone, between the on-off valve (B) and the on-off valve (C) and between the on-off valve (D) and the on-off valve (E), respectively. Zone, between the on-off valve (C) and the on-off valve (G) and A structure in which each provided with the sterile Eazon during closing (H) and the on-off valve (D), the liquid in one column or a part sequence of the branch pipe was fed under sterile conditions, the remaining other column The filter can be exchanged or cleaned , and the upstream side of the on-off valve (A) of the branch pipe in the other row and the stop line without stopping the liquid feeding from the upstream side to the downstream side of the pipe line while holding the downstream side of the pipe line of the switching valve (F) in a sterile condition, wherein the other row adjacent zones in a non-high temperature state of the other row of the on-off valve (G) and the on-off valve (H) section The filter can be exchanged or washed .

The present invention according to claims 1 and 14 is an on-off valve (A) provided on the upstream side of the filter in the piping line in a method and apparatus for switching a filter provided in the middle of a piping line for sending liquid in an aseptic condition. ) And the on-off valve (F) provided on the downstream side of the filter are closed, and the liquid remaining between the on-off valve (A) and the on-off valve (F) is drained, and then the filter and the on-off valve it has to be replaced or cleaned the filter provided respectively sterile barrier zone (ST1) and sterile barrier zone with steam and the like (ST2) during the valve and between the filter and the on-off valve (a) (F) Accordingly, the downstream side of the pipeline upstream and the on-off valve valve (F) of the on-off valve (a) remains held in a sterile state, it can be exchanged or cleaned the filter With a cormorant effect. Moreover, since no high-pressure liquid remains in the filter when the filter is opened, the filter can be safely replaced or cleaned .

The present invention according to claims 2 and 15 is the pipe line filter switching method and apparatus according to claims 1 and 14, wherein the filter and sterilization barrier zone (ST1) of the pipe line and the filter and sterilization are provided. between the barrier zone (ST2), by which is adapted to replace or clean the filter each provided with a sterile Eazon (AS1) and sterile Eazon (AS2) of positive pressure, the on-off valve (C) and on-off valve ( The adjacent zone of the filter installation section during D) is brought into a non-high temperature state, and there is an effect that the filter can be safely replaced or cleaned without causing burns.

The present invention according to claims 3 and 16 is an on-off valve (A) provided on the upstream side of the filter in the piping line in a method and apparatus for switching a filter provided in the middle of a piping line for sending liquid in an aseptic condition. ) And the sterilization barrier zone (ST3), and between the on-off valve (F) provided on the downstream side of the filter and the sterilization barrier zone (ST4), a sterile air zone (AS3) and a sterile air zone (AS4) are provided. As a result, the liquid in the piping line upstream of the on-off valve (A) and downstream of the on-off valve (F) has a quality caused by high-temperature thermal effects in the sterilization barrier zone (ST3) and the sterilization barrier zone (ST4), respectively. This has the effect of eliminating the possibility of causing deterioration. Moreover, since no high-pressure liquid remains in the filter when the filter is opened, the filter can be safely replaced or cleaned .

The present invention according to claims 4 and 17 is the piping line filter switching method and apparatus according to claims 3 and 16, wherein the filter and the sterilization barrier zone (ST3) and between the sterilization barrier zone (ST4). In addition, by providing a sterile air zone (AS5) and a sterile air zone (AS6) to replace or clean the filter, the adjacent zone in the section where the filter is installed is brought into a non-high temperature state without causing burns. The filter can be safely replaced or cleaned .

The present invention according to claims 5 and 18 is the pipe line filter switching method and apparatus according to claims 4 and 17 , wherein the filter installation location can be opened and closed connected to a stationary cleaning liquid supply pipe. When replacing or cleaning the filter, not only the entire line but only the vicinity of the filter can be cleaned in place, which has an effect of being efficient.

According to a sixth aspect of the present invention, in the pipe line filter switching method according to the fifth aspect, the cleaning liquid for the stationary cleaning is fed in a direction opposite to the liquid feeding direction of the liquid in the pipe line. it makes before can backwash the notated Iruta has the effect that cleaning efficiency is increased.

The present invention according to claim 7 is the pipe line filter switching method according to claims 5 and 6, wherein the filter is washed safely without automatically removing the filter from the pipe line. It has the effect that it can be performed efficiently.

The present invention relating to claim 8, wherein the Te filter switching method smell pipe lines according to claims 5 to 7, after the pre-Symbol cleaning in place, and sterilized under predetermined conditions (temperature and time) by the steam or the like The subsequent cooling by aseptic air blowing allows the filter to be re-sterilized only in the vicinity of the filter instead of the entire line when the filter is replaced or washed. .

According to a ninth aspect of the present invention, in the pipe line filter switching method according to the eighth aspect of the present invention, after cooling with the sterilized air, the positive pressure state can be maintained with the sterilized air. Therefore, when the filter is replaced or the production operation of the piping line to be cleaned is resumed, it is possible to be in a standby state and to be efficient.

The present invention according to claims 10 and 19 is the pipe line filter switching method and apparatus according to any one of claims 1 and 5 to 9 and 14 and 18, and each of the branch pipes branching the pipe line into a plurality of rows. The sterilization barrier zone (ST1) and the sterilization barrier zone (ST2) are provided, the liquid is aseptically fed in one or a part of the branch pipes, and the filters in the remaining other rows are exchanged or washed . By doing so, the upstream side of the on-off valve (A) of the branch pipe in the other row is continued while continuing the production operation without stopping the liquid feeding from the upstream side to the downstream side of the pipe line. And it has the effect that the said filter of the said other row | line | column can be exchanged or wash | cleaned , keeping the piping line downstream of the said on-off valve (F) in a sterilized state.

The present invention according to claims 11 and 20 is the pipe line filter switching method and apparatus according to claims 2 and 5 to 9 and 15 and 18, wherein each of the branch pipes branched into a plurality of rows. , by which is adapted to replace or clean the filter the sterile Eazon (AS1) and sterile Eazon (AS2) to be provided before and after the section of the filter, the liquid from the upstream side to the downstream side of the pipe line While continuing the production operation without stopping liquid feeding, the piping lines upstream of the on-off valve (A) and downstream of the on-off valve (F) of the branch pipe in the other row are maintained in a sterile state. as non-hot conditions adjacent zone of the filter installation section of the other row, burns it without causing, secure exchange of the filter of the other column also An effect that can be washed.

The present invention according to claims 12 and 21 relates to a method and an apparatus for switching a filter provided in the middle of a piping line for sending a liquid in an aseptic condition, and each of the branch pipes branching the piping line into a plurality of rows, An aseptic air zone (AS3) and an on-off valve (A) and an on-off valve (F) provided on the upstream side and downstream side of the filter in the piping line, and between the sterilization barrier zone (ST3) and the sterilization barrier zone (ST4), respectively By providing the aseptic air zone (AS4), the on-off valve of the branch pipe in the other row is maintained while continuing the production operation without stopping the liquid feeding from the upstream side to the downstream side of the pipe line. while holding the upstream side and the on-off valve of a) downstream of the pipe line (F) in a sterile condition, the upstream side of the another row of the on-off valve (a) and Downstream of the pipeline of the liquid of the serial-off valve (F) has the effect that may occur deterioration in quality due to high temperature of the heat-affected each sterile barrier zone (ST3) and sterile barrier zone (ST4) is eliminated.

The present invention according to claims 13 and 22 is the pipe line filter switching method and apparatus according to claims 12 and 21, wherein the filter and the sterilization barrier are provided in each of branch pipes in which the pipe line is branched into a plurality of rows. By providing a sterilized air zone (AS5) and a sterilized air zone (AS6) between the zone (ST3) and the filter and the sterilization barrier zone (ST4), respectively, and replacing or cleaning the filters in the other rows , while continuing the production run without stopping the liquid feed of the liquid from the upstream side to the downstream side of the pipe line, upstream and the on-off valve of the other row of the branch pipes of the on-off valve (a) ( the downstream side of the pipe line F) remain kept in sterile conditions, the non-hot-like adjacent zone of the filter installation section of the other row As, it has the effect that burns it without causing can replace or clean the filter safely the other columns.

It is a model drawing of the line incorporating the filter switching device of the piping line concerning the 1st Embodiment of this invention. In FIG. 1, it is a figure explaining the state by which the piping line and an apparatus are wash-in-place. In FIG. 1, it is a figure explaining the state in which the piping line and apparatus are steam-sterilized. In FIG. 1, it is a figure explaining the state by which the piping line and an apparatus are cooled by ventilation of aseptic air. In FIG. 1, a filling liquid is sent to a piping line on one filter side and filled with a filler, and is a diagram for explaining a state in which the other filter side is on standby. In FIG. 1, it is a figure explaining the state which is going to switch the liquid feeding of the filling liquid from the one filter side to the other filter side. In FIG. 1, a state in which the filling liquid is sent to the piping line on the other filter side and filled with the filler, and the remaining filling liquid on the one filter side that has been used until then is drained will be described. FIG. In FIG. 1, it is a figure explaining the state which is going to remove a filter for washing | cleaning by the side of one filter, and is filling the filler with the filling liquid being sent to a piping line by the other filter side. In Figure 1, the filter upstream and downstream while the vapor barrier on one filter side, the filters were washed constant location and the filling liquid in the pipe line in the other filter side is fed filler in filled It is a figure explaining a state. 1 is a diagram steam sterilized after the filter was washed constant location on one filter side, is fed the filling liquid in the pipe line in the other filter side filler illustrating a state during filling. In FIG. 1, it is a figure explaining the state in which it cools by the ventilation of aseptic air after steam sterilization on one filter side, and the filling liquid is sent to the piping line on the other filter side and the filler is being filled. FIG. 1 is a diagram for explaining a state in which a pipe line is placed on standby in a positive pressure state of aseptic air on one filter side, and a filler liquid is fed to the pipe line on the other filter side and a filler is being filled. FIG. 3 is a schematic diagram of a line incorporating a filter switching device for a piping line according to a second embodiment of the present invention, and corresponds to FIG. 1. In FIG. 13, it is a figure explaining the sterilization barrier zone at the time of washing | cleaning or replacement | exchange of a filter. It is a model diagram of the line incorporating the filter switching device of the piping line concerning the 3rd Embodiment of this invention, and is a figure equivalent to FIG. FIG. 16 is a schematic diagram of a line incorporating a filter switching device for a piping line according to a fourth embodiment of the present invention, corresponding to FIGS. 1 and 15.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. Note that the present invention is not limited to the embodiments. In addition, constituent elements in the following embodiments include those that can be easily assumed by those skilled in the art or those that are substantially the same.

(First Embodiment of the Invention)
A first embodiment of the present invention will be described with reference to FIGS.
FIG. 1 is a schematic diagram of a line incorporating a pipe line filter switching device according to the first embodiment of the present invention.
FIG. 2 is a diagram illustrating a state in which the piping line and the equipment are cleaned in place in FIG.
FIG. 3 is a view for explaining a state in which the piping line and the equipment are steam sterilized in FIG.
FIG. 4 is a diagram for explaining a state in which the piping line and the equipment in FIG. 1 are cooled by blowing sterile air.
FIG. 5 is a diagram for explaining a state in FIG. 1 in which the filling liquid is sent to the piping line on one filter side and filled with the filler, and is on standby on the other filter side.
FIG. 6 is a diagram illustrating a state in which the filling liquid feeding is to be switched from one filter side to the other filter side in FIG. 1.
FIG. 7 shows that the filling liquid is sent to the piping line on the other filter side in FIG. 1 and filled with the filler, and the remaining filling liquid on the one filter side that has been used is drained. It is a figure explaining a state.
FIG. 8 is a diagram illustrating a state in which the filter is removed for cleaning on one filter side in FIG. 1 and the filler is being supplied to the piping line by the other filter and the filler is being filled.
9, in FIG. 1, the filter upstream and downstream while the vapor barrier on one filter side, the filters were washed constant location and the filling liquid in the pipe line in the other filter side is fed filler FIG. 8 is a diagram for explaining a state during filling.
10, in FIG. 1, a diagram steam sterilized after the filter was washed constant location on one filter side, is filled liquid fed to the pipeline by the other filter-side filler describing a state during the filling is there.
FIG. 11 is a view for explaining a state in which the filler is filled with the filler liquid being fed to the piping line on the other filter side after being sterilized with steam after being sterilized by steam on the one filter side in FIG. is there.
FIG. 12 illustrates a state in FIG. 1 in which the pipe line is placed on standby in the positive pressure state of aseptic air on one filter side, and the filler is being fed to the pipe line on the other filter side and the filler is being filled. FIG.

  In FIG. 1, the liquid that has been fed and stored in the liquid tank 20 from the direction of the arrow S <b> 1 is bifurcated from the liquid tank 20 into two lines of piping lines 6 or 16 at a branching point 5 a of the piping line 22. The liquid is fed, and the liquid is further fed to the filler 21 via the junction 5b.

  A filter switching device 1 is provided in the piping line 6 and the piping line 16, and the filter switching device 1 is provided with a filter 2 and a filter 12 in the middle of the piping line 6 and the piping line 16, respectively. Foreign matter in the liquid to be fed is removed, and the upstream and downstream piping lines 6 of the filter 2 are provided with an opening / closing valve 6a and an opening / closing valve 6f, and The piping line 16 upstream and downstream of the filter 12 is provided with an opening / closing valve 16a and an opening / closing valve 16f so as to open and close the liquid feeding.

  Further, the filter switching device 1 is provided with an on-off valve 6b and an on-off valve 6c in the piping line 6 on the upstream side of the filter 2 in addition to the on-off valve 6a toward the filter 2 side. In addition to the on-off valve 6f, an on-off valve 6e and an on-off valve 6d are provided on the side piping line 6 toward the filter 2, and a stationary cleaning liquid supply device 7 is provided between the filter 2 and the on-off valve 6d. Open / close valve 7a for supplying cleaning liquid to pipe line 6 from pipe 7p, and opening / closing for sending stationary cleaning liquid in pipe line 6 in the direction of arrow 7d between filter 2 and open / close valve 6c. A valve 7 b is provided to form an open / close connection mechanism with the piping line 6.

  Further, between the on-off valve 6a and the on-off valve 6b of the pipe line 6, and between the on-off valve 6e and the on-off valve 6f, a pipe 9p1 branched from the steam supply device 9 into a pipe 9p and a pipe 9p, respectively. And an on-off valve 9a and an on-off valve 9b for supplying steam to the pipe line 6 via the pipe 9p2, and an on-off valve 9c and an on-off valve 9d for draining steam from the pipe line 6 in the directions of arrows 9d1 and 9d2, respectively. An opening / closing connection mechanism with the piping line 6 is formed.

  A sterile air (clean air; hereinafter referred to as aseptic air) supply device 8 is provided between the on-off valve 6b and the on-off valve 6c of the piping line 6 and between the on-off valve 6d and the on-off valve 6e. An on-off valve 8a and an on-off valve 8b for supplying aseptic air to the piping line 6 via the piping 8p1 and the piping 8p2 respectively branched from the piping 8p and the piping 8p, and an aseptic air from the piping line 6 with an arrow 8d1 and an arrow, respectively An on-off valve 8c and an on-off valve 8d for purging in the direction of 8d2 are provided to form an on-off connection mechanism with the piping line 6.

  Further, the filter switching device 1 includes an open / close valve 16b on the upstream side of the filter 12 and an open / close valve 16b toward the filter 12 in addition to the open / close valve 16a, as in the case of the pipe line 6. A valve 16c is provided, and an on-off valve 16e and an on-off valve 16d are provided on the piping line 16 on the downstream side of the filter 12 in addition to the on-off valve 16f toward the filter 12, and the filter 12 and the on-off valve Between 16d, the on-off valve 17a for supplying the washing liquid to the pipe line 16 from the stationary washing liquid supply device 7 via the pipe 17p, and between the filter 12 and the on-off valve 16c, the stationary washing liquid in the pipe line 16 is provided. Is provided with an opening / closing valve 17b for supplying liquid in the direction of arrow 17d to form an opening / closing connection mechanism with the piping line 16.

  Further, between the on-off valve 16a and the on-off valve 16b, and between the on-off valve 16e and the on-off valve 16f, a pipe 19p and a pipe 19p2 branched from the steam supply device 9 into a pipe 19p and a pipe 19p, respectively. An on-off valve 19a and an on-off valve 19b for supplying steam to the piping line 16, and an on-off valve 19c and an on-off valve 19d for draining steam from the piping line 16 in the directions of arrows 19d1 and 19d2, respectively. And an open / close connection mechanism.

  Further, between the on-off valve 16b and the on-off valve 16c of the pipe line 16 and between the on-off valve 16d and the on-off valve 16e, a pipe 18p1 branched from the aseptic air supply device 8 into a pipe 18p and a pipe 18p, respectively. On-off valve 18a and on-off valve 18b for supplying aseptic air to the piping line 16 via the piping 18p2, and on-off valve 18c and on-off valve for purging aseptic air from the piping line 16 in the directions of arrows 18d1 and 18d2, respectively. 18 d is provided to form an open / close connection mechanism with the piping line 16.

  Here, the on-off valve 6a to the on-off valve 6f, the on-off valve 7a and the on-off valve 7b, the on-off valve 8a to the on-off valve 8d, the on-off valve 9a to the on-off valve 9d, and the on-off valve 16a to the on-off valve 16f, The on-off valve 17a and on-off valve 17b, the on-off valve 18a to on-off valve 18d, the on-off valve 19a to on-off valve 19d, etc. are operated by operation of an operation panel (not shown) or control of the control device 10.

  In addition, when the cleaning liquid is supplied from the stationary cleaning liquid supply device 7 in the direction of arrow S1 via a piping line (not shown), the piping line 22, the piping line 6 or the piping line 16, and the piping line 22 are connected from the liquid tank 20. The liquid passage to the filler 21 is cleaned in place, and is returned from the filler 21 to the stationary cleaning liquid supply device 7 via a piping line (not shown) in the direction of the arrow S2 to circulate a predetermined type of cleaning liquid in a predetermined time. Thus, the pipe line for feeding the liquid and the stationary cleaning of the equipment are performed.

  Further, when steam is supplied from the steam supply device 9 in the direction of arrow S1 via a pipe line (not shown), the liquid tank 20 passes through the pipe line 22, the pipe line 6 or the pipe line 16, and the pipe line 22. Then, the liquid passage to the filler 21 is steam sterilized, and the steam is drained from the filler 21 through a pipe (not shown) in the direction of the arrow S2.

  Further, aseptic air is supplied from the aseptic air supply device 8 in the direction of arrow S1 via a pipe (not shown), the pipe line 22, pipe line 6 or pipe line 16, and pipe line 22 are connected from the liquid tank 20. The liquid passage to the filler 21 is cooled by blowing sterilized air after the steam sterilization, and the sterilized air is purged from the filler 21 to a piping line (not shown) in the direction of the arrow S2.

  As described above, the liquid passage from the liquid tank 20 to the filler 21 via the piping line 22, the piping line 6 or the piping line 16, and the piping 22 includes stationary cleaning, subsequent steam sterilization, and subsequent aseptic air blowing. After cooling is performed, liquid (beverage, pharmaceutical liquid, etc.) is supplied in the direction of arrow S1 via a piping line (not shown), and is supplied from the liquid tank 20 to the piping line 22, piping line 6 or piping line 16, and piping. It is supplied to the filler 21 via the line 22 and is filled in a container (not shown) with the filler 21.

Next, the operation of the filter switching device 1 for piping lines according to the first embodiment of the present invention will be described.
On-off valve 7a, on-off valve 7b, on-off valve 8a, on-off valve 8b, on-off valve 8c, on-off valve 8d, on-off valve 9a, on-off valve 9b, on-off valve 9c, on-off valve 9d, and on-off valve 17a, on-off valve 17b, on-off valve 18a, on-off valve 18b, on-off valve 18c, on-off valve 18d, on-off valve 19a, on-off valve 19b, on-off valve 19c, on-off valve 19d are closed, and the on-off valve 6a, on-off valve 6b, on-off valve 6c, The on-off valve 6d, the on-off valve 6e, the on-off valve 6f, and the on-off valve 16a, the on-off valve 16b, the on-off valve 16c, the on-off valve 16d, the on-off valve 16e, and the on-off valve 16f are opened, and the stationary cleaning liquid is supplied from the arrow S1 direction. Then, the cleaning liquid circulates in the liquid passage from the liquid tank 20 to the filler 21 via the piping line 22, the piping line 6 or the piping line 16, and the piping line 22, as indicated by a broken thick line in FIG. 2. Then, when stationary cleaning is performed, and then steam is supplied from the direction of arrow S1, steam is supplied and steam sterilized as shown by the thick dashed line in FIG. 3, and then sterile air is supplied from the direction of arrow S1. As shown by the thick double-dashed line in 4, aseptic air is blown, cooling is performed and preparation for aseptic filling is completed.

Thereafter, the on-off valve 16a and the on-off valve 16f are closed, and a positive pressure state is established between the on-off valve 16a and the on-off valve 16f by the supply of aseptic air from the aseptic air supply device 8, and the on-off valve 6a, on-off valve 6b, When the on-off valve 6c, the on-off valve 6d, the on-off valve 6e, and the on-off valve 6f are opened and the liquid is supplied from the direction of the arrow S1, the liquid passes through the filter 2 to the filler 21 as shown by the solid thick line in FIG. Then, the container 21 (not shown) can be filled with liquid from the filler 21.
Note that the liquid is supplied to the filler 21 only in the pipe line 6 for the sake of explanation in the above description, but may be supplied through both the pipe line 6 and the pipe line 16. Since this does not limit the intention of the present invention, a detailed description thereof will be omitted.

  When the filter 2 has passed through the filter 2 for a predetermined time and needs to be cleaned or replaced due to clogging or the like, the on-off valve 16a, the on-off valve 16b, the on-off valve 16c, the on-off valve 16d, the on-off valve 16e, After the valve 16f is opened and liquid is allowed to pass through both the piping line 6 and the piping line 16, as shown by the solid thick line in FIG. 6, first, the on-off valve 6a and the on-off valve 6f are closed. 7, the liquid is allowed to pass only to the piping line 16 side as indicated by the bold solid line, so that the on-off valve 7 a, the on-off valve 9 a, and the on-off valve 9 b are closed, and the on-off valve 7 b or the on-off valve 7 b The valve 8c, the on-off valve 8d, the on-off valve 9c, and the on-off valve 9d are opened, and the piping line 6 passes through the on-off valve 8a and the on-off valve 8b from the aseptic air supply device 8 as shown by the two-dot chain line in FIG. Supply sterile air to As a result, the liquid remaining in the piping line 6 between the on-off valve 6a and the on-off valve 6f is transferred from the on-off valve 7b or the on-off valve 7b, the on-off valve 8c, the on-off valve 8d, the on-off valve 9c, and the on-off valve 9d. Drained.

  In addition, the thick two-dot chain line shown in FIG. 6 represents a state where the supply of aseptic air is stopped by the on-off valve 8a, the on-off valve 8b, the on-off valve 18a, and the on-off valve 18b (both are closed). Yes. FIG. 7 shows a state in which liquid is drained from the on-off valve 7b, on-off valve 8c, on-off valve 8d, on-off valve 9c, and on-off valve 9d, and the drain of the liquid is a two-dot chain thick line. Show. (Hereinafter, this description is duplicated and may be omitted.)

  After the liquid remaining in the piping line 6 between the opening / closing valve 6a and the opening / closing valve 6f is drained, the opening / closing valve 6b and the opening / closing valve 6e are closed, and the opening / closing valve 9a, the opening / closing valve 9b, the opening / closing valve 9c, By opening the valve 9d and supplying steam from the steam supply device 9 to the pipe line 6 as shown by a thick dotted line in FIG. 8, between the on-off valve 6a and the on-off valve 6b of the pipe line 6, and Between the on-off valve 6e and the on-off valve 6f is a sterilization barrier zone ST1 and a sterilization barrier zone ST2, respectively. Liquid is aseptic on the upstream side of the on-off valve 6a and downstream of the on-off valve 6f of the piping line 6. The state is maintained.

In addition, as shown by the thick double-dashed line in FIG. 8, the on-off valve 8a, on-off valve 8b, on-off valve 8c, and on-off valve 8d are opened to open the on-off valve 6b and the on-off valve 6c, and between the on-off valve 6d and on-off valve. By supplying aseptic air from the aseptic air supply device 8 during 6e, the section between the on-off valve 6c and the on-off valve 6d is separated from the sterilization barrier zone ST1 and the sterilization barrier zone ST2. When washing or replacing by hand, the sterilization barrier zone ST1 and the sterilization barrier zone ST2 are not affected by heat due to steam sterilization, that is, the adjacent zone between the on-off valve 6c and the on-off valve 6d is set to a non-high temperature state. burn it without causing it possible to safely remove the filter 2, the intake with.

As described above, the sterilization barrier zone ST1 and the sterilization barrier zone ST2 replace or clean the liquid on the upstream side of the on-off valve 6a and the downstream side of the on-off valve 6f of the pipe line 6 in a sterile state by clogging or the like. However, in this case, the remaining liquid in the filter 2 is drained as described above, so that the atmospheric pressure is lower than the atmospheric pressure. The pressure is not high and can be removed safely.

  After cleaning and mounting the filter 2, the on-off valve 8a, on-off valve 8b, on-off valve 8c, on-off valve 8d, on-off valve 9a, on-off valve 9b, on-off valve 9c, on-off valve 9d are closed, on-off valve 7a and on-off valve 7b is opened, and the stationary cleaning liquid is supplied from the stationary cleaning liquid supply device 7 to the piping line 6 as shown by a thick broken line in FIG. 9, and the filter 2 is also provided between the opening / closing valve 6b and the opening / closing valve 6e of the piping line 6. Including fixed cleaning. (FIG. 9 shows a state in which aseptic air is supplied to the pipe 8p1 and the pipe 8p2 with the on-off valve 8a and the on-off valve 8b being closed.)

In the above description, the case where the filter 2 is manually removed, washed and mounted has been described. However, the filter 2 can be automatically cleaned by stationary cleaning without removing the filter 2 by hand.
The automatic cleaning of the filter 2 described above is a so-called reverse cleaning in which the liquid feeding direction of the stationary cleaning liquid to the filter 2 is opposite to the liquid feeding direction. The liquid feeding direction of the stationary cleaning liquid to the filter 2 may be the same as the liquid feeding direction, but the reverse cleaning is preferable because it has a higher cleaning effect.

  Further, when the filter 2 is cleaned in place, since the steam sterilization barrier is provided between the on-off valve 6a and the on-off valve 6b of the piping line 6 and between the on-off valve 6e and the on-off valve 6f, the stationary cleaning liquid is supplied to the pipe. There is no fear of flowing into the upstream side of the on-off valve 6a and the downstream side of the on-off valve 6f of the line 6, and the liquid is safe without being contaminated.

  After stationary cleaning including the filter 2 between the on-off valve 6c and the on-off valve 6d, the on-off valve 7a is closed with the on-off valve 8a, the on-off valve 8b, the on-off valve 8c, and the on-off valve 8d closed, and the on-off valve 9a When the on-off valve 6b and the on-off valve 6e are opened while the on-off valve 9b, the on-off valve 9c, and the on-off valve 9d are opened, the on-off valve 6a of the piping line 6 is shown in FIG. Steam sterilization is performed between the on-off valve 6f.

  Subsequently, the on-off valve 9a and the on-off valve 9b are closed, the on-off valve 6b, the on-off valve 6e, the on-off valve 8a, the on-off valve 8b, the on-off valve 8c, and the on-off valve 8d are opened, and FIG. As indicated by the bold line, aseptic air is supplied from the aseptic air supply device 8 to the piping line 6, and the space between the on-off valve 6 a and the on-off valve 6 f of the piping line 6 is cooled in a sterile state by blowing sterile air. The

After cooling with the sterilized air blow, the on-off valve 8c, on-off valve 8d, on-off valve 9c, and on-off valve 9d are closed, and as shown by the two-dot chain line in FIG. the by sterile air to remain supplied, in positive pressure state between the sterile air on-off valve 6a and the on-off valve 6f of the pipeline 6, the filter 2 i.e. filter switching device 1 is in a standby state, exchange of the filter 2 Alternatively, although the cleaning is completed, when the liquid passage through the piping line 6 is resumed, measures such as closing the on-off valve 8a and the on-off valve 8b are taken.

  When the passage of liquid through the filter 12 elapses for a predetermined time and the filter 12 is clogged or the like and needs to be cleaned, the on-off valve 6a and the on-off valve 6f are opened, and liquid is supplied to both the piping line 6 and the piping line 16. After the passage, the on-off valve 16a and the on-off valve 16f are closed so that liquid passes only to the piping line 6, the on-off valve 17a, the on-off valve 19a, and the on-off valve 19b are closed, and the on-off valve 17d Alternatively, the on-off valve 17d, the on-off valve 18c, the on-off valve 18d, the on-off valve 19c, and the on-off valve 19d are opened, and the pipe line 16 is opened via the on-off valve 18a and on-off valve 18b opened from the aseptic air supply device 8. By supplying aseptic air to the on-off valve 16a, the liquid remaining in the piping line 16 between the on-off valve 16a and the on-off valve 17d, the on-off valve 17d, and the on-off valve 18 The on-off valve 18d, the on-off valve 19c, and the on-off valve 19d are drained, and the filter 12 can be cleaned or replaced in the same manner as the cleaning or replacement of the filter 2 described above. Is omitted.

  In the above description, the case where the piping line 22 is branched into two rows of the piping line 6 and the piping line 16 and the filter 2 and the filter 12 are provided in the middle of the branched piping line 6 and the piping line 16 has been described. Three or more branch piping lines with filters may be provided. In this case as well, the liquid on the upstream side of the on-off valve 6a and the downstream side of the on-off valve 6f is maintained in a sterile state in the piping line to be switched by the sterilization barrier zone. The filter can be cleaned or replaced as it is, but the method and apparatus are similar in contents, and detailed description thereof is omitted.

Next, a filter switching device 31 according to a second embodiment of the present invention will be described with reference to FIGS.
FIG. 13 is a schematic diagram of a line incorporating a filter switching device for a piping line according to the second embodiment of the present invention, and corresponds to FIG.
FIG. 14 is a diagram for explaining a sterilization barrier zone at the time of cleaning or replacement of the filter in FIG.
In FIG. 13 and FIG. 14, the same structure as FIG.

In FIG. 13 and FIG. 14, the filter switching device 31 has four on-off valves 6a, 6b, 6e, and 6f as the on-off valves provided in the piping line 6, and the filter 2 as the on-off valves 6b and 6f. 6b is provided between the on-off valve 6a and the on-off valve 6b and between the on-off valve 6e and the on-off valve 6f, and the on-off valve 6a and the on-off valve 6b. The sterilization barrier zone ST1 and the sterilization barrier zone ST2 are provided between the open / close valve 6e and the open / close valve 6f, and an open / close connection mechanism with a pipe from the sterile air supply device 8 is provided between the open / close valve 6a and the open / close valve 6b. Also, it is provided between the on-off valve 6e and the on-off valve 6f. After the filter 2 is washed, the section between the on-off valve 6b and the on-off valve 6e is cleaned in place, and the steam is sterilized between the on-off valve 6a and the on-off valve 6f. It is constituted to be cooled by blowing sterile air through the opening of tube connection-off valve 8a and the on-off valve 8b from charging device 8.
The same applies to the piping line 16, but the description is omitted because of overlapping contents.

  Here, the on-off valve 6a to the on-off valve 6f, the on-off valve 7a and the on-off valve 7b, the on-off valve 8a to the on-off valve 8d, the on-off valve 9a to the on-off valve 9d, and the on-off valve 16a to the on-off valve 16f, The on-off valve 17a and on-off valve 17b, the on-off valve 18a to on-off valve 18d, the on-off valve 19a to on-off valve 19d, and the like are operated by operation of an operation panel (not shown) or control of the control device 30.

The operation of the filter switching device 31 for the piping line according to the second embodiment of the present invention will be described.
When the filter 2 is cleaned or replaced , the on-off valve 16a, the on-off valve 16b, the on-off valve 16e, and the on-off valve 16f are opened so that liquid can pass through the piping line 16, and the on-off valve 6a and the on-off valve 6f is closed, the open / close valve 7a, the open / close valve 9a, and the open / close valve 9b are closed, and the open / close valve 7b or the open / close valve 7b, the open / close valve 8c, the open / close valve 8d, the open / close valve 9c, and the open / close valve 9d are opened. By supplying aseptic air from the aseptic air supply device 8 to the piping line 6 via the on-off valve 8a and the on-off valve 8b, the liquid remaining in the piping line 6 between the on-off valve 6a and the on-off valve 6f is removed. The on-off valve 7b or the on-off valve 7b, the on-off valve 8c, the on-off valve 8d, the on-off valve 9c, and the on-off valve 9d is drained.

  After the liquid remaining in the piping line 6 between the opening / closing valve 6a and the opening / closing valve 6f is drained, the opening / closing valve 6b and the opening / closing valve 6e are closed, and the opening / closing valve 8a, the opening / closing valve 8b, the opening / closing valve 8c, The valve 8d is closed, the opening / closing valve 9a, the opening / closing valve 9b, the opening / closing valve 9c, and the opening / closing valve 9d are opened, and the steam is supplied from the steam supply device 9 to the piping line 6, thereby being shown by a thick dashed line in FIG. As described above, the sterilization barrier zone ST1 and the sterilization barrier zone ST2 are provided between the on-off valve 6a and the on-off valve 6b of the piping line 6 and between the on-off valve 6e and the on-off valve 6f, respectively, upstream of the on-off valve 6a of the piping line 6. The liquid and the downstream side of the on-off valve 6f are maintained in a sterile state.

In this state, the filter 2 in the section between the on-off valve 6b and the on-off valve 6e can be removed by hand from the piping line 6 and washed, and the washed filter 2 can be mounted. In this case, since the liquid remaining in the filter 2 is drained as described above, the pressure is not higher than the atmospheric pressure and can be removed safely. When the filter 2 is removed by hand, the adjacent zone in the section between the on-off valve 6b and the on-off valve 6e is in a high temperature state. Therefore, it is desirable to perform automatic cleaning without removing the filter 2 by hand as much as possible for safety.
After the filter 2 is installed or in the state of automatic cleaning of the filter 2, the on-off valve 6b and the on-off valve 6e are closed, and the on-off valve 8a, on-off valve 8b, on-off valve 8c, on-off valve 8d, on-off valve 9a, on-off The valve 9b, the opening / closing valve 9c, and the opening / closing valve 9d are closed, the opening / closing valve 7a and the opening / closing valve 7b are opened, the stationary cleaning liquid is supplied from the stationary cleaning liquid supply device 7 to the piping line 6, and the opening / closing valve 6b of the piping line 6 The space between the on-off valve 6e including the filter 2 is cleaned in place.

After the filter 2 is cleaned in place, the on-off valve 8a, on-off valve 8b, on-off valve 8c and on-off valve 8d are closed, on-off valve 9a, on-off valve 9b, on-off valve 9c and on-off valve 9d are opened, and the steam supply device 9 By supplying steam to the piping line 6, steam sterilization is performed between the on-off valve 6 a and the on-off valve 6 f.
After the steam sterilization, the open / close valve 9a, the open / close valve 9b, the open / close valve 9c, and the open / close valve 9d are closed, and the open / close valve 8a, the open / close valve 8b, the open / close valve 8c, and the open / close valve 8d are opened. Aseptic air is supplied to the piping line 6 to cool the space between the on-off valve 6a and the on-off valve 6f with aseptic air. After cooling, the on-off valve 8c and the on-off valve 8d are closed, and the on-off valve 6a and on-off valve 6f are closed. Is maintained in a positive pressure state by aseptic air, and the cleaning or replacement of the filter 2 is completed.

Since even replacement or cleaning of the filter 12 is the same as the exchange or cleaning of the filter 2 of the description, overlapping description is omitted, in the case of the second embodiment, provided in the pipeline 6 and the pipe line 16 opening It is possible to reduce the number of valves from four in the case of the first embodiment (on-off valve 6a to on-off valve 6f and on-off valve 16a to on-off valve 16f) to four each.

Next, a filter switching device 41 according to a third embodiment of the present invention will be described with reference to FIG.
FIG. 15 is a schematic diagram of a line incorporating a filter switching device for a piping line according to the third embodiment of the present invention, and corresponds to FIG.
In FIG. 15, the same structure as that in FIG.
In FIG. 15, the liquid sent and stored from the direction of arrow S <b> 1 to the liquid tank 20 is bifurcated from the liquid tank 20 into a two-line pipe line 36 or a pipe line 46 at a branch point 5 a of the pipe line 22. The liquid is fed, and the liquid is further fed to the filler 21 via the junction 5b.

  The piping line 36 and the piping line 46 are provided with a filter switching device 41, and the filter switching device 41 is provided with the filter 2 and the filter 12 in the middle of the piping line 36 and the piping line 46, respectively. The foreign matter in the liquid to be fed is removed, and the upstream and downstream piping lines 36 of the filter 2 are provided with an opening / closing valve 36a and an opening / closing valve 36f, In addition, an on-off valve 46 a and an on-off valve 46 f are provided on the upstream and downstream piping lines 46 of the filter 12 so that the liquid feeding is opened and closed.

  The filter switching device 41 is provided with an opening / closing valve 36b and an opening / closing valve 36c toward the filter 2 in addition to the opening / closing valve 36a in the piping line 36 upstream of the filter 2, and downstream of the filter 2 In addition to the on-off valve 36f, an on-off valve 36e and an on-off valve 36d are provided on the side piping line 36 toward the filter 2, and a stationary cleaning liquid supply device 7 is provided between the filter 2 and the on-off valve 36d. Open / close valve 7a for supplying cleaning liquid to pipe line 36 via pipe 7p, and opening / closing for sending stationary cleaning liquid in pipe line 36 in the direction of arrow 7d between filter 2 and open / close valve 36c. A valve 7b is provided to form an open / close connection mechanism with the piping line 36.

  Further, between the on-off valve 36a and the on-off valve 36b of the pipe line 36 and between the on-off valve 36e and the on-off valve 36f, pipes branched from the aseptic air supply device 38 into the pipe 38p and the pipe 38p, respectively. An open / close valve 38a and an open / close valve 38b for supplying aseptic air to the pipe line 36 via 38p1 and the pipe 38p2, and an open / close valve 38c and an open / close valve for purging aseptic air from the pipe line 36 in the directions of arrows 38d1 and 38d2, respectively. A valve 38d is provided to form an opening / closing connection mechanism with the piping line 36.

  Further, between the on-off valve 36b and the on-off valve 36c of the pipe line 36 and between the on-off valve 36d and the on-off valve 36e, a pipe 39p1 branched from the steam supply device 39 into a pipe 39p and a pipe 39p, respectively. An on-off valve 39a and an on-off valve 39b for supplying steam to the pipe line 36 via the pipe 39p2, and an on-off valve 39c and an on-off valve 39d for draining steam from the pipe line 36 in the directions of arrows 39d1 and 39d2, respectively. An opening / closing connection mechanism with the piping line 36 is formed.

  Further, the filter switching device 41 includes an opening / closing valve 46b on the upstream side of the filter 12 and an opening / closing valve 46b toward the filter 12 in addition to the opening / closing valve 46a, as in the case of the piping line 36. A valve 46c is provided, and an on-off valve 46e and an on-off valve 46d are provided on the piping line 46 on the downstream side of the filter 12 in addition to the on-off valve 46f toward the filter 12, and the filter 12 and the on-off valve The on-off valve 17a for supplying the cleaning liquid to the piping line 46 from the stationary cleaning liquid supply device 7 via the pipe 17p between the stationary cleaning liquid supply device 7 and the stationary cleaning liquid in the piping line 46 between the filter 12 and the on-off valve 46c. Is provided with an opening / closing valve 17b for supplying the liquid in the direction of the arrow 17d to form an opening / closing connection mechanism with the piping line 46.

  Further, between the on-off valve 46a and the on-off valve 46b of the pipe line 46 and between the on-off valve 46e and the on-off valve 46f, a pipe 48p1 branched from the aseptic air supply device 38 into a pipe 48p and a pipe 48p, respectively. On-off valve 48a and on-off valve 48b for supplying aseptic air to the piping line 46 via the piping 48p2, and on-off valve 48c and on-off valve for purging aseptic air from the piping line 46 in the directions of arrows 48d1 and 48d2, respectively. 48d is provided to form an open / close connection mechanism with the piping line 46.

  Further, between the on-off valve 46b and the on-off valve 46c, and between the on-off valve 46d and the on-off valve 46e, a pipe 49p1 and a pipe 49p2 branch from the steam supply device 39 to the pipe 49p and the pipe 49p, respectively. An on-off valve 49a and an on-off valve 49b for supplying steam to the piping line 46, and an on-off valve 49c and an on-off valve 49d for draining steam from the piping line 46 in the directions of arrows 49d1 and 49d2, respectively, are provided. And an open / close connection mechanism.

  Here, the on-off valve 36a to the on-off valve 36f, the on-off valve 7a and the on-off valve 7b, the on-off valve 38a to the on-off valve 38d, the on-off valve 39a to the on-off valve 39d, and the on-off valve 46a to the on-off valve 46f, The on-off valve 17a and on-off valve 17b, the on-off valve 48a to on-off valve 48d, the on-off valve 49a to on-off valve 49d, etc. are operated by operation of an operation panel (not shown) or control of the control device 40.

  In addition, the liquid passage from the liquid tank 20 to the filler 21 via the piping line 22, the piping line 36 or the piping line 46, and the piping line 22 is fixedly cleaned by the cleaning liquid supplied from the stationary cleaning liquid supply device 7, The steam sterilization with the steam supplied from the steam supply device 39 and the cooling with the sterile air supplied from the aseptic air supply device 38 are the same as in the case of FIG. Description is omitted.

  As described above, the liquid passage from the liquid tank 20 to the filler 21 via the piping line 22, the piping line 36 or the piping line 46, and the piping 22 includes stationary cleaning, subsequent steam sterilization, and subsequent aseptic air. After cooling by blowing, liquid (beverage, pharmaceutical liquid, etc.) is supplied in the direction of arrow S1 via a piping line (not shown), and from the liquid tank 20 to the piping line 22, piping line 36 or piping line 46, It is supplied to the filler 21 via the piping line 22 and filled in a container (not shown) with the filler 21.

Next, the operation of the pipe line filter switching device 41 according to the third embodiment of the present invention will be described.
The liquid passage from the liquid tank 20 to the filler 21 via the piping line 22, the piping line 36 and the piping line 46, and the piping line 22 is prepared for aseptic filling by stationary cleaning, steam sterilization, and cooling with aseptic air blowing. After that, the on-off valve 46a and the on-off valve 46f are closed, and a positive pressure is provided between the on-off valve 36a and the on-off valve 36f by the supply of aseptic air from the aseptic air supply device 38, and the on-off valve 36a, on-off valve 36b When the liquid is supplied from the direction of the arrow S1 with the open / close valve 36c, the open / close valve 36d, the open / close valve 36e, and the open / close valve 36f open, the liquid passes through the filter 2 and is supplied to the filler 21. The liquid can be filled with the liquid, but since the contents are the same as those described in the first embodiment, the detailed description is omitted.

  When the filter 2 passes through the filter 2 for a predetermined time and needs to be cleaned or replaced due to clogging or the like, the on-off valve 46a, the on-off valve 46b, the on-off valve 46c, the on-off valve 46d, the on-off valve 46e, In a state where the valve 46f is opened and liquid passes through the piping line 46, the on-off valve 36a and the on-off valve 36f are closed, the on-off valve 7a, the on-off valve 39a, and the on-off valve 39b are closed, and the on-off valve 7b Alternatively, the on-off valve 7b, the on-off valve 38c, the on-off valve 38d, the on-off valve 39c, and the on-off valve 39d are opened, and aseptic air is supplied from the aseptic air supply device 38 to the piping line 36 via the on-off valve 38a and on-off valve 38b. By supplying the liquid, the liquid remaining in the piping line 36 between the opening / closing valve 36a and the opening / closing valve 36f is the opening / closing valve 7b, or the opening / closing valve 7b, the opening / closing valve 38c, and the opening / closing valve 38d. Off valve 39c, it is drained from the on-off valve 39d.

After the liquid remaining in the piping line 36 between the opening / closing valve 36a and the opening / closing valve 36f is drained, the opening / closing valve 36b, the opening / closing valve 36c, the opening / closing valve 36d, the opening / closing valve 36e, and the opening / closing valve 38a, 38b, the on-off valve 38c, the on-off valve 38d are closed, the on-off valve 39a, the on-off valve 39b, the on-off valve 39c, and the on-off valve 39d are opened, and the piping line from the steam supply device 39 through the on-off valve 39a and the on-off valve 39b By supplying steam to 36, the sterilization barrier zone ST3 and the sterilization barrier zone ST4 by steam are provided between the on-off valve 36b and the on-off valve 36c of the piping line 36 and between the on-off valve 36d and the on-off valve 36e, respectively. In addition, the aseptic valve 38a and the on-off valve 38a are connected between the on-off valve 36a and the on-off valve 36b, and between the on-off valve 36e and the on-off valve 36f. By supplying aseptic air via the valve closing 38b, the aseptic air zone AS3 and the aseptic air zone AS4 between the on-off valve 36a and the on-off valve 36b and between the on-off valve 36e and the on-off valve 36f are aseptic air and positive pressure, respectively. Thus, the filter 2 that needs to be replaced or cleaned due to clogging is manually removed from the piping line 36 while the liquid upstream of the switching valve 36a and downstream of the switching valve 36f of the piping line 36 is maintained in a sterile state. The filter 2 after washing can be attached.

  After the filter 2 is mounted, the on-off valve 7a and the on-off valve 7b are opened, and the stationary cleaning liquid is circulated and supplied from the stationary cleaning liquid supply device 7 to the piping line 36. The filter 2 is also cleaned in place.

In the above description, the filter 2 is removed by hand, washed, and mounted. However, the filter 2 can be automatically washed by stationary cleaning without being removed by hand.
This automatic cleaning of the filter 2 is a so-called reverse cleaning in which the liquid feeding direction of the stationary cleaning liquid to the filter 2 is opposite to the liquid feeding direction. The liquid feeding direction of the stationary cleaning liquid to the filter 2 may be the same as the liquid feeding direction, but the reverse cleaning is preferable because it has a higher cleaning effect.

In addition, when the filter 2 is attached, removed or fixedly cleaned, a sterile air zone AS3 and a sterile air zone AS4 are provided between the open / close valve 36a and the sterilization barrier zone ST3 of the piping line 36 and between the open / close valve 36f and the sterilization barrier zone ST4, respectively. Therefore, the liquid on the upstream side of the opening / closing valve 36a and the downstream side of the opening / closing valve 36f of the piping line 36 is not affected by the heat of steam sterilization, and the deterioration of the liquid due to the heat can be prevented. it can.
In addition, when the filter 2 is cleaned in place, the presence of the sterilization barrier zone ST3 and sterilization barrier zone ST4 and the sterilization air zone AS3 and sterilization air zone AS4 causes the stationary cleaning liquid to flow upstream of the on-off valve 36a of the piping line 36 and There is no fear of flowing into the downstream side of the on-off valve 36f, and the liquid is safe without being contaminated.

  After stationary cleaning including the filter 2 between the on-off valve 36c and the on-off valve 36d, the on-off valve 7a, the on-off valve 38a, the on-off valve 38b, the on-off valve 38c, and the on-off valve 38d are closed, and the on-off valve 39a, on-off valve 39b, The opening / closing valve 39c and the opening / closing valve 39d are opened, the opening / closing valve 36b, the opening / closing valve 36c, the opening / closing valve 36d, and the opening / closing valve 36e are opened, and steam is supplied from the steam supply device 39 to the piping line 36. Steam sterilization is performed between the on-off valve 36a and the on-off valve 36f.

  Subsequently, the on-off valve 39a, the on-off valve 39b, the on-off valve 39c, and the on-off valve 39d are closed, the on-off valve 38a, the on-off valve 38b, the on-off valve 38c, and the on-off valve 38d are opened. By supplying aseptic air to 36, the space between the on-off valve 36a and the on-off valve 36f of the piping line 36 is cooled in an aseptic state by blowing sterile air.

After cooling with the sterilized air blow, the on-off valve 38c and the on-off valve 38d are closed, and the sterilized air is supplied to the piping line 36 from the sterilizing air supply device 38, thereby opening and closing the on-off valve 36a of the piping line 36. Between the valve 36f is a positive pressure of sterile air, the filter 2, that is, the filter switching device 41 is in a standby state, and the cleaning or replacement of the filter 2 is completed, but when the liquid passage through the pipe line 36 is resumed, Countermeasures such as closing the on-off valve 38a and the on-off valve 38b are taken.

For even cleaning or replacement of the filter 12 when the liquid passes through the filter 12 is a filter 12 in the predetermined time elapses is needed is washed with clogging, since the same as that in the case of cleaning or replacement the filter 2 Detailed description will be omitted.

Next, a filter switching device 51 according to a fourth embodiment of the present invention will be described with reference to FIG.
FIG. 16 is a schematic diagram of a line incorporating a pipe line filter switching device according to the fourth embodiment of the present invention, and corresponds to FIGS. 1 and 15.
In FIG. 16, the same structures as those in FIGS. 1 and 15 are denoted by the same reference numerals, and redundant description is omitted.
The filter switching device 51 is provided with an on-off valve 36g and an on-off valve 36h between the filter 2 and the on-off valve 36c and between the filter 2 and the on-off valve 36d of the piping line 36, respectively. Between the on-off valve 7a for supplying the cleaning liquid from the stationary cleaning liquid supply device 7 to the piping line 36 via the pipe 7p, and between the filter 2 and the on-off valve 36g, the stationary cleaning liquid in the piping line 36 is provided. Is provided with an opening / closing valve 7b for supplying the liquid in the direction of the arrow 7d to form an opening / closing connection mechanism with the piping line 36.

  The filter switching device 51 includes a pipe 38p3 and a pipe branched from the aseptic air supply device 38 and the pipe 38p between the on-off valve 36c and the on-off valve 36g and between the on-off valve 36h and the on-off valve 36d. An on-off valve 38e and an on-off valve 38f for supplying aseptic air to the piping line 36 via 38p4, and an on-off valve 38g and an on-off valve 38h for purging aseptic air from the piping line 36 in the directions of arrows 38d3 and 38d4, respectively. And an open / close connection mechanism with the piping line 36 is formed, and aseptic air zone AS5 and aseptic air zone between the on-off valve 36c and the on-off valve 36g and between the on-off valve 36h and the on-off valve 36d are aseptic air and positive pressure, respectively. It is configured to be AS6.

  Further, the filter switching device 51 is provided with an opening / closing valve 46g and an opening / closing valve 46h between the filter 12 and the opening / closing valve 46c and between the filter 12 and the opening / closing valve 46d, respectively. Between the open / close valve 46h, the open / close valve 17a that supplies the cleaning liquid to the pipe line 46 from the stationary cleaning liquid supply device 7 via the pipe 17p, and between the filter 12 and the open / close valve 46g, An open / close valve 17b for supplying the stationary cleaning liquid in the direction of the arrow 17d is provided to form an open / close connection mechanism with the piping line 46.

  Further, the filter switching device 51 includes a pipe 48p3 and a pipe branched from the aseptic air supply device 38 and the pipe 48p between the on-off valve 46c and the on-off valve 46g and between the on-off valve 46h and the on-off valve 46d. An on-off valve 48e and an on-off valve 48f for supplying aseptic air to the piping line 46 via 48p4, and an on-off valve 48g and an on-off valve 48h for purging aseptic air from the piping line 46 in the directions of arrows 48d3 and 48d4, respectively. An open / close connection mechanism with the piping line 46 is provided, and the aseptic air zone is formed between the open / close valve 46c and the open / close valve 46g and between the open / close valve 46h and the open / close valve 46d.

  It should be noted that between the on-off valve 36a and the on-off valve 36b of the piping line 36 and between the on-off valve 36e and the on-off valve 36f are respectively aseptic air zone AS3 and aseptic air zone AS4 of positive pressure with aseptic air, Between the on-off valve 36b and the on-off valve 36c of the piping line 36, and between the on-off valve 36d and the on-off valve 36e are the sterilization barrier zone ST3 and the sterilization barrier zone ST4 by steam, respectively. Similarly, the provision of the sterile air zone and the sterilization barrier zone is the same as in the case of the third embodiment, and a duplicate description is omitted.

  Here, the on-off valve 36a to the on-off valve 36h, the on-off valve 7a and the on-off valve 7b, the on-off valve 38a to the on-off valve 38h, the on-off valve 39a to the on-off valve 39d, and the on-off valve 46a to the on-off valve 46h, The on-off valve 17a and on-off valve 17b, the on-off valve 48a to on-off valve 48h, the on-off valve 49a to on-off valve 49d, etc. are operated by operation of an operation panel (not shown) or control of the control device 50.

The operation of the filter switching device 51 for the piping line according to the fourth embodiment of the present invention will be described.
When the filter 2 is washed or exchanged , aseptic air is supplied between the on-off valve 36c and the on-off valve 36g and between the on-off valve 36h and the on-off valve 36d, which is set as a sterile air zone AS5 or a sterile air zone AS6, respectively. Is manually affected by heat sterilization between the on-off valve 36b and the on-off valve 36c and between the on-off valve 36d and the on-off valve 36e. As non-hot conditions adjacent zone thereby closing valve 36g and the on-off valve 36h of the interval, burns it without causing, safely remove the filter 2, mounting only can be possible to.
In addition, since it is the same as that of the case where the filter 2 is wash | cleaned or replaced | exchanged also when wash | cleaning or replacing | exchanging the filter 12, the overlapping description is abbreviate | omitted.

1, 31, 41, 51 Piping line filter switching device 2, 12 Filter 5a Branching point 5b Junction point 6, 16, 36, 46 (branched) piping lines 6a-6f, 16a-16f, 36a-36h, 46a- 46h Open / close valve 7 Stationary cleaning liquid supply device 7a, 7b, 17a, 17b Open / close valve 7p, 17p Pipe 8, 38 Aseptic (clean) air supply device 8a-8d, 18a-18d, 38a-38d, 48a-48d Open / close valve 8p, 8p1-8p4, 18p1-18p4 Piping 9, 39 Steam supply devices 9a-9d, 19a-19d, 39a-39d, 49a-49d On-off valve 9p, 9p1, 9p2, 19p, 19p1, 19p2 Piping 10, 30, 40, 50 Control device 20 Liquid tank 21 Filler 22 Piping line 38p, 38p1-38p4, 4 p1~48p4 pipe 39p, 39p1,39p2,49p, 49p1,49p2 piping

Claims (22)

In a method of switching a filter provided in the middle of a piping line for sending liquid in an aseptic condition,
The on-off valve (A) provided on the upstream side of the filter in the piping line and the on-off valve (F) provided on the downstream side of the filter are closed, and the on-off valve (A) and the on-off valve (F) After draining the liquid remaining in between, the on-off valve (B) and the on-off valve (E) provided between the filter and the on-off valve (A) and between the filter and the on-off valve (F) are closed. Then, between the on-off valve (A) and the on-off valve (B) and between the on-off valve (E) and the on-off valve (F) are opened and connected by an on-off valve with a pipe of sterilization means such as steam. As the sterilization barrier zone (ST1) and sterilization barrier zone (ST2) by steam, etc., the piping lines upstream of the on-off valve (A) and downstream of the on-off valve (F) are maintained in a sterile state. characterized in that to replace or clean the filter Filter switching method of the pipe line to be. In the piping line filter switching method according to claim 1,
The on-off valve (C) and the on-off valve (D) further provided between the filter and the on-off valve (B) and between the filter and the on-off valve (E) of the piping line are closed, respectively. (B) and the on-off valve (C) and between the on-off valve (D) and the on-off valve (E) are opened and connected by an on-off valve with a sterile air supply pipe, and a positive pressure state with aseptic air is used. Piping lines characterized by exchanging or washing the filter in a non-high temperature state in the adjacent zone between the on-off valve (C) and the on-off valve (D) as a sterile air zone (AS1) and a sterile air zone (AS2), respectively. Filter switching method. In a method of switching a filter provided in the middle of a piping line for sending liquid in an aseptic condition,
The on-off valve (A) provided on the upstream side of the filter in the piping line and the on-off valve (F) provided on the downstream side of the filter are closed, and the on-off valve (A) and the on-off valve (F) After draining the liquid remaining in between, the on-off valve (B) and the on-off valve (E) provided between the filter and the on-off valve (A) and between the filter and the on-off valve (F) are closed. Then, between the on-off valve (A) and the on-off valve (B) and between the on-off valve (E) and the on-off valve (F) are opened and connected with an on-off valve with a sterile air supply pipe, respectively. As a sterilized air zone (AS3) and a sterilized air zone (AS4) respectively brought into a positive pressure state by air, and between the filter and the on-off valve (B) of the piping line and between the filter and the on-off valve (E), respectively. Open / close valve (C And the on-off valve (D) is closed, and piping between the on-off valve (B) and the on-off valve (C) and between the on-off valve (D) and the on-off valve (E) are sterilization means such as steam, respectively. And the sterilization barrier zone (ST3) and sterilization barrier zone (ST4) by steam or the like, respectively, upstream of the on-off valve (A) and downstream of the on-off valve (F). A filter switching method for a piping line, characterized in that the filter is replaced or washed while the piping line is maintained in a sterile state. In the pipe line filter switching method according to claim 3,
The on-off valve (G) and the on-off valve (H) further provided between the filter and the on-off valve (C) and between the filter and the on-off valve (D) of the piping line are closed, respectively. (C) and the open / close valve (G) and between the open / close valve (H) and the open / close valve (D) are opened and closed by the open / close valve with the sterile air supply pipe, respectively, so that the positive pressure is generated by the sterile air. As the aseptic air zone (AS5) and aseptic air zone (AS6), the piping is characterized in that the filter is replaced or washed in a non-high temperature state in the adjacent zone between the on-off valve (G) and the on-off valve (H). Line filter switching method. In the pipe line filter switching method according to claim 4 ,
Between the on-off valve (B) and the on-off valve (E) immediately before and after the filter, between the on-off valve (C) and the on-off valve (D), or between the on-off valve (C) and the on-off valve (D). A pipe characterized in that the filter is cleaned by stationary cleaning with an open / close valve between the open / close valve (G) and the open / close valve (H) as an open connection state with a fixed cleaning liquid supply pipe Line filter switching method. In the pipe line filter switching method according to claim 5,
A pipe line filter switching method, wherein the stationary cleaning liquid is sent in a direction opposite to the liquid feeding direction of the pipe line to reversely wash the filter. In the pipe line filter switching method according to claim 5 or 6,
Filter switching method of the pipe line, characterized by automatic cleaning without removing the front notated Iruta from the pipe line. In the piping line filter switching method according to any one of claims 5 to 7,
Before After cleaning in place a notated Iruta, the on-off valve (A) and the on-off valve (F) between the predetermined condition by the steam or the like as the connection condition of the opening in the opening and closing valve and piping sterilizing means such as steam ( Sterilization by temperature, time, etc., or, after sterilization by the steam, etc., and switching by a sterile air supply air as an open connection state with an open / close valve with a sterile air supply pipe, and switching the filter of the piping line Method. In the piping line filter switching method according to claim 8,
Filter switching of a piping line characterized in that between the on-off valve (A) and the on-off valve (F) is sterilized with steam, cooled with the sterilized air blow, and then maintained in a positive pressure state with the sterilized air. Method. In the piping line filter switching method according to any one of claims 1 and 5 to 9,
For each branch pipe that branches the pipe line into a plurality of rows, the filter, on-off valve (A), on-off valve (B), on-off valve (E), on-off valve (F), sterilization barrier zone (ST1) and sterilization A barrier zone (ST2) is provided, the liquid is sent in aseptic condition in one or a part of the branch pipes, and the other filters in the other line are exchanged or washed , and the upstream of the pipe line Without stopping the liquid feeding from the side to the downstream side, the piping line upstream of the on-off valve (A) and the downstream side of the on-off valve (F) of the branch pipe in the other row is made sterile. A pipe line filter switching method , wherein the filter in the other row is replaced or washed while being held. In the pipe line filter switching method according to any one of claims 2 and 5 to 9,
In each of the branch pipes that branch the pipe line into a plurality of rows, the filter, the on-off valve (A), the on-off valve (B), the on-off valve (C), the on-off valve (D), the on-off valve (E), the on-off valve (F), a sterilization barrier zone (ST1), a sterilization barrier zone (ST2), a sterilization air zone (AS1) and a sterilization air zone (AS2) are provided, and liquid is sent in a sterile state in one or a part of the branch pipes. Open and close the branch pipes in the other row without stopping liquid feeding from the upstream side to the downstream side of the pipe line by replacing or cleaning the remaining other rows of the filters. While holding the piping line upstream of the valve (A) and downstream of the on-off valve (F) in an aseptic state, the adjacent zone of the section between the on-off valve (C) and the on-off valve (D) in the other row the filter of the other row in a non-high temperature state Filter switching method of the pipe line, characterized by replacement or cleaning. In the piping line filter switching method according to any one of claims 3 and 5 to 9,
In each of the branch pipes that branch the pipe line into a plurality of rows, the filter, the on-off valve (A), the on-off valve (B), the on-off valve (C), the on-off valve (D), the on-off valve (E), the on-off valve (F) A sterile air zone (AS3), a sterile air zone (AS4), a sterilization barrier zone (ST3), and a sterilization barrier zone (ST4) are provided, and liquid is sent in a sterile state in one or a part of the branch pipes. Open and close the branch pipes in the other row without stopping liquid feeding from the upstream side to the downstream side of the pipe line by replacing or cleaning the remaining other rows of the filters. A filter switching method for a piping line, characterized in that the filter in the other row is replaced or washed while the piping line upstream of the valve (A) and downstream of the on-off valve (F) is maintained in a sterile state. . In the piping line filter switching method according to any one of claims 4 and 5 to 9,
In each of the branch pipes branching the piping line into a plurality of rows, the filter, the on-off valve (A), the on-off valve (B), the on-off valve (C), the on-off valve (G), the on-off valve (H), the on-off valve (D), on-off valve (E), on-off valve (F), sterile air zone (AS3) and sterile air zone (AS4) and sterile barrier zone (ST3) and sterile barrier zone (ST4), further sterile air zone (AS5) and sterile An air zone (AS6) is provided, the liquid is aseptically fed in one or a part of the branch pipes, and the filter in the other part of the other lines is exchanged or washed , so that the upstream side of the pipe line Without stopping the flow of the liquid from the downstream to the downstream side, the piping line upstream of the on-off valve (A) and the downstream side of the on-off valve (F) of the branch pipe in the other row is maintained in a sterile state. It remains, the other Filter switching method of the pipe line, characterized by replacement or cleaning the filter of the other row adjacent zones in a non-high temperature state of the section of the on-off valve (G) and the on-off valve (H). In the device that switches the filter provided in the middle of the piping line that sends liquid in aseptic condition,
The piping line is provided with an on-off valve (A) and an on-off valve (F) on the upstream side and downstream side of the filter, respectively, and remains between the on-off valve (A) and the on-off valve (F) in a closed state. An open / close connection mechanism with a drain pipe is provided so that liquid can be drained, and an open / close valve (B) and an open / close valve are provided between the filter and the open / close valve (A) and between the filter and the open / close valve (F), respectively. (E) is provided, and an on-off connection mechanism between the on-off valve (A) and the on-off valve (B) and between the on-off valve (E) and the on-off valve (F) is connected to a pipe of sterilization means such as steam. By providing each, it is configured as a sterilization barrier zone for steam, etc., and the filter is replaced while keeping the piping lines upstream of the on-off valve (A) and downstream of the on-off valve (F) in a sterile state. or washing can be as Pipeline of the filter switching device, characterized in that the. In the piping line filter switching device according to claim 14,
An on-off valve (C) and an on-off valve (D) are provided between the filter and the on-off valve (B) and between the filter and the on-off valve (E), respectively. And an open / close connection mechanism with a sterile air supply pipe between the open / close valve (D) and the open / close valve (E). A piping line filter switching device characterized in that the filter can be replaced or washed in a non-high temperature state in an adjacent zone of the section of the on-off valve (D). In the device that switches the filter provided in the middle of the piping line that sends liquid in aseptic condition,
The piping line is provided with an on-off valve (A) and an on-off valve (F) on the upstream side and the downstream side of the filter, respectively, and remains between the on-off valve (A) and the on-off valve (F) in a closed state. An open / close connection mechanism with a drain pipe is provided so that the liquid can be drained, and an open / close valve (B) and an open / close valve are provided between the filter and the open / close valve (A) and between the filter and the open / close valve (F), respectively. A valve (E) is provided, and an on-off connection mechanism is provided between the on-off valve (A) and the on-off valve (B) and between the on-off valve (E) and the on-off valve (F) with a sterile air supply pipe. Thus, each is configured as a positive pressure aseptic air zone, and further, between the filter and the on-off valve (B) and between the filter and the on-off valve (E), the on-off valve (C) and the on-off valve (D), respectively. Providing the opening and closing Sterilization of steam or the like by providing an open / close connection mechanism between the on-off valve (C) and the on-off valve (D) and the on-off valve (E) with the piping of sterilization means such as steam. It is configured as a barrier zone so that the filter can be replaced or cleaned while the piping lines upstream of the on-off valve (A) and downstream of the on-off valve (F) are maintained in a sterile state. Filter switching device for piping line. In the piping line filter switching device according to claim 16,
An on-off valve (G) and an on-off valve (H) are provided between the filter and the on-off valve (C) of the piping line and between the filter and the on-off valve (D), respectively. By providing an open / close connection mechanism with a sterile air supply pipe between the valve (G) and between the open / close valve (H) and the open / close valve (D), respectively, it is configured as a positive pressure sterile air zone. A pipe line filter switching device characterized in that the filter can be exchanged or washed in a non-high temperature state in an adjacent zone between the valve (G) and the on-off valve (H). In the piping line filter switching device according to claim 17 ,
Between the on-off valve (B) and the on-off valve (E) immediately before and after the filter, between the on-off valve (C) and the on-off valve (D), or between the on-off valve (C) and the on-off valve (D). Or a line having an open / close connection mechanism with a stationary cleaning liquid supply pipe between the open / close valve (G) and the open / close valve (H) so that the filter can be automatically cleaned. Filter switching device. In the piping line filter switching device according to claim 14 or 18,
The piping line is branched into a plurality of rows, and the filter, the on-off valve (A), the on-off valve (B), the on-off valve (E), the on-off valve (F), the on-off valve ( A) open / close connection mechanism with a drain pipe for draining liquid remaining between the open / close valve (F), between the open / close valve (A) and the open / close valve (B), and between the open / close valve (E) and the open / close valve ( F) The sterilization barrier zone is provided during each of the steps F) so that the liquid can be sent in aseptic condition in one or a part of the branch pipes, and the filters in the remaining other lines can be replaced or washed. The upstream side of the on-off valve (A) and the downstream side of the on-off valve (F) of the branch pipe in the other row without stopping the liquid feeding from the upstream side to the downstream side of the pipe line. of the pipeline while holding the sterile, the filter of the other row 換又the filter switching device of the pipe line, characterized in that to be able to wash. In the piping line filter switching device according to claim 15 or 18,
The piping line is branched into a plurality of rows, and the filter, on-off valve (A), on-off valve (B), on-off valve (C), on-off valve (D), on-off valve ( E), an on-off valve (F), an on-off connection mechanism with a drain pipe for draining liquid remaining between the on-off valve (A) and the on-off valve (F), the on-off valve (A) and the on-off valve (B) The sterilization barrier zone, between the on-off valve (B) and the on-off valve (C) and between the on-off valve (D) and the on-off valve (E) ) Between each of the branch pipes so that the liquid can be sent in aseptic condition and the remaining other rows of the filters can be replaced or cleaned. without stopping the liquid feed of the liquid from the upstream side to the downstream side of the pipe line, wherein While holding the upstream side and the on-off valve of the on-off valve of the branch pipe column (A) downstream of the pipe line (F) in a sterile condition, the other column of the on-off valve (C) and the on-off valve ( A filter switching device for a piping line, wherein the filter in the other row can be exchanged or switched in a non-high temperature state in an adjacent zone in the section D). In the piping line filter switching device according to claim 16 or 18,
The piping line is branched into a plurality of rows, and the filter, on-off valve (A), on-off valve (B), on-off valve (C), on-off valve (D), on-off valve ( E), an on-off valve (F), an on-off connection mechanism with a drain pipe for draining liquid remaining between the on-off valve (A) and the on-off valve (F), the on-off valve (A) and the on-off valve (B) Between the on-off valve (E) and the on-off valve (F), between the aseptic air zone, between the on-off valve (B) and the on-off valve (C), and between the on-off valve (D) and the on-off valve (E). As a configuration in which the sterilization barrier zone is provided in between, the liquid is sent in aseptic condition in one or a part of the branch pipes, and the other filters in the other lines can be replaced or washed , without stopping the liquid feed of the liquid from the upstream side to the downstream side of the pipeline, the other column While holding the sterile downstream of the pipeline upstream and the on-off valve (F) of the on-off valve of the branch pipe (A), that it has to be able to exchange or clean the filter of the other row Features a filter switching device for piping lines. In the piping line filter switching device according to claim 17 or 18,
The piping line is branched into a plurality of rows, and the filter, on-off valve (A), on-off valve (B), on-off valve (C), on-off valve (G), on-off valve ( H), an on-off valve (D), an on-off valve (E), an on-off valve (F), an on-off connection mechanism with a drain pipe for draining liquid remaining between the on-off valve (A) and the on-off valve (F), Between the on-off valve (A) and the on-off valve (B) and between the on-off valve (E) and the on-off valve (F), respectively, between the aseptic air zone, the on-off valve (B) and the on-off valve (C), and Between the on-off valve (D) and the on-off valve (E), the sterilization barrier zone, between the on-off valve (C) and the on-off valve (G), and between the on-off valve (H) and the on-off valve (D), respectively. As a configuration in which each of the aseptic air zones is provided, the liquid is sent in a sterile state in one or a part of the branch pipes. , And to exchange or clean the filter of the remaining other columns, it said without stopping the liquid feed of the liquid from the upstream side to the downstream side of the pipe line, the on-off valve of the branch pipe of the other row ( The adjacent zone of the section between the on-off valve (G) and the on-off valve (H) in the other row is kept at a non-high temperature while keeping the piping line upstream of A) and the downstream side of the on-off valve (F) in a sterile state. A filter switching device for a piping line, wherein the filter in the other row can be replaced or cleaned in a state.

Images