JP6227301B2 - Aseptic gloves - Google Patents

Description

  The present invention relates to a mounting structure for an aseptic operation glove provided in an aseptic-compatible isolator.

  In many cases, an isolator including a sterile chamber that is shielded from the outside air is used for tests using cells and microorganisms in the medical field and the development of pharmaceuticals. The isolator is usually glass-coated on the front surface, and a plurality of glove ports for attaching a glove toward the inside of the chamber are provided on the wall surface so that the inside of the chamber can be operated from outside through the glass.

  When the inside of the isolator is decontaminated with gas, in order to decontaminate the surface of the glove, a glove holder is attached to the inside of the glove, and the glove is held in an extended state inside the isolator (see Patent Document 1). ).

Japanese Patent No. 4619228

  On the other hand, the glove is arranged near the mechanical equipment inside the isolator in consideration of operability. Therefore, in the structure of patent document 1, the glove hold | maintained at a glove holder at the time of decontamination will be in the state which contacts a mechanical installation often, and a contact part may not be decontaminated. In addition, if the internal device is operated in order to enhance the decontamination effect, the glove may be damaged due to contact with the device.

  An object of the present invention is to enable effective decontamination while maintaining the operability of a glove in an aseptic isolator.

1st invention is provided in the opening part of the isolator by which an inside is maintained in a sterilized state, and in the aseptic operation glove which an operator wears from the outside, the ring-shaped port part provided in the opening part of the isolator, A cylindrical portion having an outer diameter smaller than the inner diameter of the ring-shaped port portion through which the operator's arm can be inserted, and an outer dimension larger than the inner diameter of the ring-shaped port portion extending radially outward from the cylindrical portion. A glove mounting member comprising a flange-shaped base portion, a glove mounted on the cylindrical portion of the glove mounting member, and a cylindrical portion provided between the flange-shaped base portion and the port portion of the glove mounting member positioned outside the isolator. And an expansion / contraction means that allows the glove attachment member to move forward and backward between the port portion and the approach position while maintaining the airtightness of the surrounding space of the glove. In the case of decontaminating the inside of the tube, the glove mounting member is set to the separation position and the glove is pulled out to the outside of the isolator. The glove attached to the cylindrical part enables the work in the isolator, and is provided inside the cylindrical part and supports the glove in the isolator with the glove pulled out to the outside of the isolator. A glove for aseptic operation of an isolator characterized by comprising a glove holder .

  The second invention is characterized in that, in the first invention, a glove holder provided inside the cylindrical portion and supporting the glove in the isolator is provided.

  According to a third invention, in the first invention, the expansion / contraction means includes a cylindrical bellows member, and the airtightness of the cylindrical portion between the flange-like base portion and the port portion of the globe mounting member and the surrounding space of the globe is It is characterized by being maintained by.

  According to a fourth aspect of the present invention, in the first aspect, the expansion / contraction means includes a multistage cylindrical member in which a plurality of cylinders are connected in a telescopic manner so that the expansion / contraction means can be expanded and contracted, and the cylindrical portion between the flange-shaped base portion and the port portion of the globe mounting member And the airtightness of the surrounding space of the glove is maintained by the multistage cylindrical member.

  According to a fifth invention, in the first invention, the expansion / contraction means includes a housing member having a double cylindrical structure and a cylindrical extending member fitted between the double cylinders, and the flange of the globe mounting member The airtightness of the cylindrical portion between the cylindrical base portion and the port portion and the surrounding space of the globe is maintained by the housing member and the extending member.

  According to a sixth invention, in the first invention, the expansion / contraction means includes an expansion member that expands by injecting fluid, and the airtightness of the cylindrical portion between the flange-like base portion and the port portion of the globe mounting member and the surrounding space of the globe is It is maintained by the expansion member.

  According to the present invention, effective decontamination can be performed in an aseptic-compatible isolator while maintaining the operability of the aseptic operation glove.

It is a sectional side view of the glove for aseptic operation of 1st Embodiment in the arrangement | positioning which performs decontamination. FIG. 2 is a side cross-sectional view of the aseptic operation glove of FIG. 1 in a working arrangement. It is a sectional side view of the glove for aseptic operation of 2nd Embodiment in the arrangement | positioning which performs decontamination. It is a sectional side view of the glove for aseptic operation of 3rd Embodiment in the arrangement | positioning which performs decontamination. It is a sectional side view of the glove for aseptic operation of 4th Embodiment in the arrangement | positioning which performs decontamination.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. 1 and 2 are side sectional views of the aseptic operation glove according to the first embodiment of the present invention. FIG. 1 shows a state when the isolator is decontaminated, and FIG. 2 shows the use of the glove. The state when performing work is shown.

  The aseptic operation glove 10 according to the first embodiment includes a ring-shaped port portion 13 provided on a wall surface 12 of an isolator 11, a glove attachment member 15 to which a glove 14 is attached, and between the port portion 13 and the glove attachment member 15. And an expandable / contractible bellows member (extension / contraction means) 16. In the first embodiment, the support member 17 is used to maintain the posture of the globe attachment member 15.

  The glove attachment member 15 includes a substantially cylindrical tubular portion 15A into which an operator inserts an arm, and a flange-shaped base portion 15B extending radially outward from a proximal end portion corresponding to an insertion port side end portion of the tubular portion 15A. The two are integrally formed. In addition, the globe 14 is airtightly attached to the outer periphery of the distal end peripheral edge that is opposite to the base end of the cylindrical portion 15A by using fastening means such as an O-ring 18.

  The port portion 13 is airtightly attached to an opening provided in the wall surface 12 of the isolator 11. In the center of the port portion 13, a substantially circular insertion port 13 </ b> A for inserting the globe 14 and the cylindrical portion 15 </ b> A is provided. Further, the outer peripheral diameter of the cylindrical portion 15A of the globe mounting member 15 is smaller than the inner diameter of the insertion port 13A of the port portion 13, and the outer diameter of the flange-shaped base portion 15B of the globe mounting member 15 is set to the insertion port 13A of the port portion 13. It is larger than the inner diameter.

  In the first embodiment, a cylindrical bellows member 16 is used as the expansion / contraction means, and one end thereof is airtightly connected to the outer surface of the port portion 13 so as to surround the insertion port 13A. The other end of the bellows member 16 is airtightly connected to the flange-like base portion 15B of the globe attachment member 15 so as to surround the tubular portion 15A. Thereby, the glove attachment member 15 and the port portion 13 are hermetically connected by the bellows member 16 provided therebetween, and the airtightness of the space around the cylindrical portion 15A and the globe 14 is maintained.

  Further, in the flange-like base portion 15B, a support member attachment hole 15C for engaging the support member 17 is provided further radially outside the position where the bellows member 16 is connected. In the present embodiment, the support member 17 is, for example, a plurality of rod-shaped members, and is inserted through the support member attachment hole 15C and arranged along the axial direction of the cylindrical portion 15A. The tip of the support member 17 is in contact with the outer surface of the port portion 13.

  In the present embodiment, the support member 17 is used in the state of FIG. 1 where the inner side 11A of the isolator 11 is decontaminated, and is attached to the flange-like base portion 15B as described above. At the time of decontamination, a glove holder 19 for maintaining the attitude of the glove 14 is mounted in the glove 14, and the glove holder 19 is engaged and held inside the cylindrical portion 15A, for example. The flange-like base portion 15B is moved in a direction away from the port portion 13 with the support member 17 as a guide, and the globe attachment member 15 is disposed at a position separated from the port portion 13 shown in FIG.

  At this time, the bellows member 16 is stretched to the outside 11B of the isolator 11, and the globe 14 whose posture is maintained by the globe holder 19 is pulled into the bellows member 16 through the insertion port 13A of the port portion 13. In other words, the globe 14 is decontaminated with the decontamination gas in a hermetically maintained space inside the bellows member 16. In FIG. 1, only the arm portion of the globe 14 is drawn inside the bellows member 16 and the position of the portion ahead of the wrist is maintained on the inner side 11 </ b> A of the isolator 11. It may be configured to be drawn inside.

  On the other hand, when working in the isolator 11, the flange-like base portion 15 </ b> B is moved toward the port portion 13 along the support member 17, and the glove attachment member 15 approaches the port portion 13 shown in FIG. 2. Placed in position. At this time, the bellows member 16 is compressed and the cylindrical portion 15 </ b> A of the globe mounting member 15 is inserted into the insertion port 13 </ b> A of the port portion 13. As shown in FIG. 2, the support member 17 and the glove holder 19 are removed when the work is performed.

  As described above, according to the first embodiment, the glove attachment member can be separated from the isolator at the time of decontamination, and the glove can be drawn into the bellows member sealed from the outside to perform the decontamination. The operation can be performed by bringing the member close to the isolator and protruding the globe to a position close to the mechanical equipment in the isolator. Therefore, when the decontamination makes contact with the machinery and equipment, the situation where the contact part cannot be decontaminated can be prevented, and even if the internal equipment is operated to enhance the decontamination effect, the glove may be damaged due to contact with the equipment. There is no. Therefore, in the aseptic isolator, decontamination can be effectively performed while maintaining the operability of the glove. In addition, according to this configuration, a standard product can be used for a glove that needs to be replaced, and it is not necessary to use a dedicated glove, so that the running cost can be reduced.

  Next, a second embodiment of the present invention will be described with reference to FIG. FIG. 3 is a side sectional view of the aseptic operation glove according to the second embodiment.

  The aseptic operation glove 20 of the second embodiment differs from the aseptic operation glove 10 of the first embodiment in the configuration of the expansion and contraction means, and does not use the support member 17 unlike the first embodiment. The rest of the configuration is the same as that of the first embodiment, and the same reference numerals are used for the same configuration and the description thereof is omitted.

  The expansion / contraction means of the second embodiment is composed of a nested multistage cylindrical member 21. In the example of FIG. 3, four-stage cylinders 21A to 21D having different diameters are arranged in a nested manner. The diameters of the cylinders 21A to 21D increase in this order. In this embodiment, the cylinder 21A is hermetically connected to the outer surface of the port portion 13 so as to surround the insertion port 13A of the port portion 13, and the cylinder 21D. However, it is airtightly connected to the flange-like base portion 15B so as to surround the tubular portion 15A.

  The cylinder 21A is fitted inside the cylinder 21B and is relatively movable in the axial direction. Similarly, the cylinder 21B is fitted inside the cylinder 21C, and the cylinder 21C is fitted inside the cylinder 21D, and can be relatively moved in the axial direction. In order to maintain airtightness between the cylinders, a packing 22A is provided between the cylinders 21A and 21B, a packing 22B is provided between the cylinders 21B and 21C, and a packing 22C is provided between the cylinders 21C and 21D. The packings 22A to 22C also function to prevent the cylinders from coming off. Thereby, the port part 13 and the flange-like base part 15B are hermetically connected by the multistage cylindrical member 21 composed of the nested cylinders 21A to 21D, and the inside of the multistage cylindrical member 21 is sealed from the outside.

  FIG. 3 shows a state in which the globe mounting member 15 is separated from the port portion 13 and arranged at a separated position. That is, the state where the multistage cylindrical member 21 is stretched and the globe 14 is pulled inside the multistage cylindrical member 21, that is, the state at the time of decontamination is shown. When projecting the globe 14 into the inner side 11 </ b> A of the isolator 11 and performing the work in the isolator 11, all the cylinders 21 </ b> A to 21 </ b> D of the multistage cylindrical member 21 are overlapped, and the globe mounting member 15 approaches the port portion 13. Placed in position.

  As described above, also in the second embodiment, the same effect as in the first embodiment can be obtained. In the second embodiment, since the nested multi-stage cylindrical member is used for the expansion / contraction means, the expansion / contraction means itself supports the attitude of the glove attachment member when the glove attachment member is arranged at the separation position. Thus, there is no need to prepare a separate support member.

  Next, a third embodiment of the present invention will be described with reference to FIG. FIG. 4 is a side sectional view of the aseptic operation glove according to the third embodiment. FIG. 4 shows a state at the time of decontamination, that is, a state where the globe is pulled out from the isolator, as in FIGS.

  The aseptic operation glove 30 of the third embodiment is used for a double wall type isolator. In the following description, the same reference numerals are used for the same configurations as those in the first embodiment, and the description thereof is omitted.

  The double wall isolator 31 is provided with an inner wall surface 32 that is parallel to the wall surface 12 at a predetermined distance inside the outer wall surface 12. In the third embodiment, the expansion / contraction means is configured using the space between the outer wall surface 12 and the inner wall surface 32. The expansion / contraction means of the third embodiment is configured as a part of the port portion 33 into which the globe 14 and the tubular portion 15A of the globe attachment member 15 are inserted.

  The port portion 33 includes a ring member 33A that is airtightly attached to the opening of the outer wall surface 12, a housing member 33B that has a substantially double cylindrical shape extending from the ring member 33A to the inner wall surface 32, and inner and outer sides of the housing member 33B. The cylindrical extending member 33C is slidably fitted between the cylindrical members and can be pulled out from the housing member 33B.

  One end of the extending member 33C is airtightly connected to the flange-like base portion 15A so as to surround the cylindrical portion 15A of the globe mounting member 15, and the other end is fitted into a gap between the double cylinders of the housing member 33B. . An end portion of the cylindrical member outside the housing member 33B facing the outer side 31B of the cylinder is hermetically connected to the ring member 33A, and an outer periphery of the end portion facing the inner side 31A is hermetically sealed in an opening provided in the inner wall surface 32. Fitted.

  In the housing member 33B, the bottom surface of the double cylinder facing the outer side 31B of the isolator 31 is released, and the extending member 33C is fitted into the gap of the double cylinder through this opening. Here, the inner diameter of the inner cylinder of the housing member 33B corresponds to the inner diameter of the port portion 33 of the present embodiment, and the globe 14 passes through the inner cylinder of the housing member 33B to the inner side 31A of the isolator 31 (inside the inner wall surface 32). In and out of space. A packing 34 for maintaining airtightness is interposed between the extending member 33C and the accommodating member 33B, and also serves as a retaining mechanism. When the work is performed by projecting the globe 14 into the inner side 31 </ b> A of the isolator 31, the cylindrical portion 15 </ b> A of the globe mounting member 15 is inserted inside the housing member 33 </ b> B and the flange-like base portion 15 </ b> B is connected to the port portion 33. The extending member 33C is accommodated between the double cylinders of the accommodating member 33B.

  As described above, the same effects as those of the first and second embodiments can be obtained in the third embodiment.

  Next, a fourth embodiment of the present invention will be described with reference to FIG. FIG. 5 is a side sectional view of the aseptic operation glove according to the fourth embodiment, and shows a state at the time of decontamination, that is, a state in which the glove is pulled out from the isolator, as in FIGS. 1, 3, and 4. .

  The aseptic operation glove 40 of the fourth embodiment is different from the aseptic operation glove 10 of the first embodiment in the configuration of its expansion and contraction means. The rest of the configuration is the same as that of the first embodiment, and the same reference numerals are used for the same configuration and the description thereof is omitted.

  In the fourth embodiment, an expansion member 41 is used that inflates by injecting a fluid having a substantially cylindrical shape into the expansion / contraction means. That is, the outer surface of the port portion 13 and the isolator-side surface of the flange-shaped base portion 15B of the globe mounting member 15 are hermetically connected by the expansion member 41, and the inner side of the expansion member 41 is from the outside 11B of the isolator 11. Sealed.

  More specifically, the expansion member 41 includes a cylindrical main body 41A, a ring-shaped connection base 41B that is airtightly connected to the outer surface of the port portion 13 so as to surround the insertion port 13A, and a cylindrical shape in the flange-shaped base portion 15B. It comprises a link-like connection base 41C that is airtightly connected so as to surround the portion 15A. The cylindrical main body 41A is made of a flexible material such as rubber, and communicates with the connection bases 41B and 41C.

  A supply tube 42 is attached to the connection base 41B, and fluid such as air can be supplied into the connection base 41B through the supply tube 42. The air supplied into the connection base 41B is guided to the cylindrical body 41A and the connection base 41C. That is, when the glove mounting member 15 is disposed at a spaced position with respect to the port portion 13, air is supplied from the supply tube 42 to inflate the cylindrical body 41A. Since the cylindrical main body 41A filled with air has a certain strength and maintains a cylindrical shape, the position of the globe mounting member 15 is held by the cylindrical main body 41A swelled into a cylindrical shape. In addition, when arrange | positioning the globe attachment member 15 in an approach position, the air of the expansion member 41 is extracted and 15 A of cylindrical parts are inserted in the insertion port 13A.

  As described above, also in the fourth embodiment, the same effect as in the first to third embodiments can be obtained.

  In the first to fourth embodiments, it is possible to provide a sensor that detects a state in which the expansion / contraction means is contracted, and to add a function of stopping the operation of the device inside the isolator in the same state.

  Moreover, in this embodiment, although the glove was directly attached to the glove attachment member, for example, a sleeve for putting an arm and a glove for putting a hand may be configured separately. In this case, a sleeve is attached to the glove attachment portion, and a glove is further attached to the tip of the sleeve.

10, 20, 30, 40 Aseptic operation gloves 11 Isolator 11A, 31A Isolator inside 11B, 31B Isolator outside 12 Wall surface 13, 33 Port portion 13A Insertion port 14 Globe 15 Globe mounting member 15A Tubular portion 15B Flange-shaped base portion 16 Bellows member 17 Support member 19 Globe holder 21 Multistage cylindrical member 31 Double wall type isolator 32 Inner wall surface 33A Ring member 33B Housing member 33C Extension member 41 Expansion member 41A Cylindrical body 41B, 41C Connection base

Claims (5)

In the glove for aseptic operation that is provided at the opening of the isolator where the inside is maintained in a sterilized state and is worn by the operator from the outside,
A ring-shaped port provided in the opening of the isolator;
A cylindrical portion that can be inserted through an operator's arm and has an outer peripheral diameter smaller than the inner diameter of the ring-shaped port portion, and extends radially outward from the cylindrical portion and larger than the inner diameter of the ring-shaped port portion A glove mounting member comprising a flange-like base portion having an outer dimension;
A glove attached to the tubular portion of the glove attachment member;
Provided between the flange-shaped base portion of the globe mounting member and the port portion positioned outside the isolator, and maintaining the airtightness of the space around the cylindrical portion and the globe, the port portion Equipped with expansion and contraction means that allows the globe mounting member to advance and retract to the approach position and the separation position,
When decontaminating the interior of the isolator, the glove mounting member is in a separated position and the glove is pulled out to the outside of the isolator,
In the state where the glove attachment member is in the approach position, the cylindrical portion is located inside the port portion, and the work inside the isolator is enabled by the glove attached to the cylindrical portion ,
For aseptic operation of an isolator , comprising a glove holder that is provided inside the cylindrical portion and supports the glove toward the inside of the isolator in a state where the glove is pulled out of the isolator. Globe.   The expansion / contraction means includes a cylindrical bellows member, and the airtightness of the cylindrical portion between the flange-like base portion of the globe mounting member and the port portion and the space around the globe is maintained by the bellows member. The aseptic operation glove according to claim 1.   The expansion / contraction means is provided with a multistage cylindrical member in which a plurality of cylinders are telescopically connected so that expansion and contraction is possible, and the cylindrical portion between the flange-like base portion of the globe mounting member and the port portion and the space around the globe are airtight. 2. The aseptic operation glove according to claim 1, wherein the glove is maintained by the multistage cylindrical member.   The expansion / contraction means includes a housing member having a double cylindrical structure, and a cylindrical extending member fitted between the double cylinders, and the flange-shaped base portion of the globe mounting member and the port portion 2. The aseptic operation glove according to claim 1, wherein the airtightness of the cylindrical portion and the surrounding space of the glove is maintained by the housing member and the extending member.   The expansion / contraction means includes an expansion member that expands by injecting fluid, and the expansion of the tubular portion between the flange-shaped base portion of the globe mounting member and the port portion and the surrounding space of the globe is maintained by the expansion member. The aseptic operation glove according to claim 1, wherein:

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