JP6440489B2 - Oral composition and oral warming agent - Google Patents

Description

  The present invention relates to an oral composition and an oral warming agent.

  Conventionally, many oral compositions have been given a refreshing feeling in order to provide a refreshing feeling. On the other hand, by giving warmth to the composition for oral cavity, there exists an advantage which the effective feeling to a medicinal effect increases. However, the warmth imparted by a warming agent such as capsaicin usually stays on the surface of the oral cavity. A sense of accomplishment is not sufficiently obtained.

  Pyrrolidone carboxylic acid is used alone or in combination with other ingredients in the oral composition to prevent and control root caries and hypersensitivity (Patent Documents 1 and 2) and prevent plaque adhesion (Patent Document) It is known to exhibit 3) and gum activation (Patent Document 4).

  On the other hand, Patent Document 5 describes that a composition containing (A) hesperidin, (B) a specific dihydric alcohol, and (C) a sugar alcohol contains hesperidin stably. Patent Document 6 describes that flavanones such as hesperidin can be an active ingredient of a tooth root caries preventive agent. Patent Document 7 describes a deodorant composition containing a thyme extract containing hesperidin. Patent Document 8 describes an epithelial sodium channel expression inhibitor containing as an active ingredient at least one selected from the group consisting of glycated hesperidin, hesperidin, and hesperetin. Patent Document 9 describes that hesperidin is stably blended in an oral composition in which at least one selected from the group consisting of xanthan gum and sodium alginate, silicic anhydride and hesperidin are blended. Patent Document 10 describes that the bitterness peculiar to a cationic fungicide is reduced by blending hesperidin in an oral composition containing a specific cationic fungicide.

International Publication No. 2013/47826 JP 2014-105181 A JP 2014-40408 A International Publication No. 2014/73490 International Publication No. 2010/90236 JP 2009-256341 A JP 2001-89340 A JP2013-91616A JP 2012-56884 A JP 2011-73970 A

  However, even in the composition for oral cavity containing pyrrolidone carboxylic acid and / or a salt thereof as in Patent Documents 1 to 4, attention is paid to warmth in the oral cavity in compositions containing hesperidin as in Patent Documents 5 to There was nothing I did.

  Furthermore, the oral composition containing pyrrolidonecarboxylic acid and / or a salt thereof tends to be insufficient in foaming properties.

  The subject of this invention is providing the composition for oral cavity which has the outstanding warmth and is excellent in foaming.

  The inventors of the present invention have made extensive studies in order to solve the above problems. As a result, it has been found that the combination of pyrrolidone carboxylic acid and / or its salt and hesperidin can improve the warmth in the oral cavity and improve the reduction of foaming due to pyrrolidone carboxylic acid and / or its salt. On the other hand, discoloration occurred in the combination, but it was found that discoloration was reduced by further adding an amphoteric surfactant.

The present invention provides the following [1] to [8].
[1] Component (A): pyrrolidonecarboxylic acid and / or a salt thereof,
(B) component: hesperidin and / or its sugar adduct,
(C) component: an amphoteric surfactant,
The composition for oral cavity containing this.
[2] The composition for oral cavity according to [1], wherein the content of the component (A) is 0.1% by mass to 10% by mass with respect to the total amount of the composition for oral cavity.
[3] The composition for oral cavity according to [1], wherein the content of the component (B) is 0.01% by mass to 10% by mass with respect to the total amount of the composition for oral cavity.
[4] The composition for oral cavity according to [1], wherein the content of the component (C) is 0.01% by mass to 10% by mass with respect to the total amount of the composition for oral cavity.
[5] Component (A): pyrrolidone carboxylic acid and / or a salt thereof,
(B) component: hesperidin and / or its sugar adduct,
(C) component: an amphoteric surfactant,
Oral warming agent containing
[6] The composition for oral cavity according to [5], wherein the content of the component (A) is 0.1% by mass to 10% by mass with respect to the total amount of the warming agent for oral cavity.
[7] The composition for oral cavity according to [5], wherein the content of the component (B) is 0.01% by mass to 10% by mass with respect to the total amount of the warming agent for oral cavity.
[8] The warming agent for oral cavity according to [5], wherein the content of the component (C) is 0.01% by mass to 10% by mass with respect to the total amount of the warming agent for oral cavity.

  ADVANTAGE OF THE INVENTION According to this invention, the composition for oral cavity and oral cavity which has the thermal sensation in an intraoral area, especially has the feeling of the arrival temperature to the back and root surface part of a gum, is excellent in foaming property, and the discoloration after storage was suppressed A warming agent can be provided.

  Hereinafter, the present invention will be described in detail with reference to preferred embodiments thereof.

  The composition for oral cavity and the warming agent for oral cavity of the present invention contain the following components (A) to (C). Thereby, the ultimate feeling of temperature, the foaming effect, and the discoloration suppressing effect are exhibited. The actual feeling of reaching temperature is a deep feeling of warmth that can be felt beyond the warmth of the oral cavity surface to the back and / or root surface of the gums.

<(A) component>
In the present invention, the component (A) is pyrrolidone carboxylic acid and / or a salt thereof.

  The salt of the component (A) is not particularly limited as long as it is a pharmacologically acceptable salt. Examples of pharmacologically acceptable salts include acid addition salts, base addition salts, and amino acid salts. Specific examples thereof include inorganic acid salts such as hydrochloride, hydrobromide, sulfate, hydroiodide, nitrate, phosphate; citrate, oxalate, acetate, formate, propion Acid salt, benzoate salt, trifluoroacetate salt, maleate salt, tartrate salt, methanesulfonate salt, benzenesulfonate salt, paratoluenesulfonate salt, etc .; sodium salt, potassium salt, calcium salt, magnesium Inorganic base salts such as salts, copper salts, zinc salts, aluminum salts, ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts, diisopropylammonium salts; lysine salts, arginine salts, histidine salts, asparagine And amino acid salts such as acid salts and glutamates. Among these salts, water-soluble salts are preferable, inorganic base salts are more preferable, alkali metal salts such as sodium salts and potassium salts are still more preferable, and sodium salts are most preferable from the viewpoint of oxidation stability.

  The manufacturing method of pyrrolidonecarboxylic acid and its salt is not specifically limited, What is necessary is just to manufacture according to a well-known scheme. For example, it can be produced by dehydrating glutamic acid and / or a salt thereof extracted from organisms such as seaweed, wheat flour, and sugarcane.

  Specific examples of pyrrolidone carboxylic acid include “AJIDEW (registered trademark) A-100” (manufactured by Ajinomoto Healthy Supply Co., Ltd.). Specific examples of sodium pyrrolidone carboxylate include “AJIDEW (registered trademark) N-50, PCA soda (AI = 50% aqueous solution)” (manufactured by Ajinomoto Healthy Supply Co., Ltd.).

  The component (A) may be one selected from pyrrolidone carboxylic acid and a salt thereof, or may be a combination of two or more different salt types and production methods.

  The content of the component (A) is preferably 0.1% by mass or more, more preferably 0.2% by mass or more, based on the total amount of the oral composition and the oral warming agent. It is still more preferable that it is 5 mass% or more. As a result, it is possible to demonstrate a sufficient sense of reaching temperature. The upper limit of the content of the component (A) is not particularly limited, but is preferably 10% by mass or less, and more preferably 8% by mass or less, with respect to the total amount of the oral composition and the oral warming agent. 6 mass% or less is particularly preferable. Thereby, foaming reduction | decrease is suppressed, it is excellent in especially viscosity stability, and can hold | maintain favorable moldability. Therefore, the content of the component (A) is preferably 0.1% by mass to 10% by mass and more preferably 0.3% by mass to 8% by mass with respect to the total amount of the oral composition and the oral warming agent. It is mass%, More preferably, it is 0.5 mass%-6 mass%.

<(B) component>
In the present invention, the component (B) is hesperidin and / or a sugar adduct thereof.

  Hesperidin is a compound in which rutinose is β-bonded to the hydroxyl group at the 7-position of hesperetin (3 ′, 5,7-trihydroxy-4′-methoxyflavanone). The hesperidin sugar adduct is a compound in which one or more sugars such as glucose, maltose, fructose, rhamnose, and lactose are bound. The sugar added in the hesperidin sugar adduct preferably contains glucose, and is preferably glycol. The number of sugars to be added is preferably one. The hesperidin sugar adduct is preferably monoglucosyl hesperidin.

  The component (B) may be hesperidin alone or hesperidin sugar adduct alone, or may be a combination of two or more selected from hesperidin and sugar adducts thereof. Therefore, it may be a combination of two or more hesperidin sugar adducts that differ in the type of sugar to be bound, the position of the sugar to be bound, and the like.

  The method for producing hesperidin and its sugar adduct is not particularly limited. Examples of the production method include chemical synthesis, means using microorganisms, extraction and isolation from natural products. Examples of natural products include citrus fruits such as Citrus unshiu and orange (Citrus aurantium L). An example of the citrus extraction site is the outer skin.

  Specific examples of the component (B) include “Hayashibara Hesperidin (registered trademark) S” (manufactured by Hayashibara Co., Ltd.).

  The content of the component (B) is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, based on the total amount of the oral composition and the oral warming agent. More preferably, it is 1% by mass or more. Thereby, especially favorable warm feeling and foaming can be obtained. The upper limit of the content of the component (B) is not particularly limited, but is preferably 10% by mass or less, and more preferably 5% by mass or less, with respect to the total amount of the oral composition and the oral warming agent. It is still more preferable that it is 3 mass% or less. Thereby, discoloration of an oral composition and an oral warming agent can be suppressed, and the fall of a usability | use_condition can be prevented. Therefore, the content of the component (B) is preferably 0.01% by mass to 10% by mass, more preferably 0.05% by mass to 5%, with respect to the total amount of the oral composition and the oral warming agent. % By mass, even more preferably 0.1% by mass to 3% by mass.

<(C) component>
In the present invention, the component (C) is an amphoteric surfactant.

  Examples of amphoteric surfactants include betaine amphoteric surfactants such as alkylbetaine amphoteric surfactants and imidazolinium betaine amphoteric surfactants, and amine oxide surfactants. Of these, betaine-type amphoteric surfactants are preferred.

  Examples of the betaine amphoteric surfactants include alkyl betaines (lauryl betaine, stearyl betaine, etc.), acetate betaines (lauryl dimethylamino acetate betaine, stearyl dimethylamino acetate betaine, etc.), imidazolinium betaines (2-alkyl-N-carboxy). Methyl-N-hydroxyethylimidazolinium betaine), N-lauroyl-N′-carboxymethyl-N′-hydroxyethylethylenediamine sodium, fatty acid amidopropyl betaine (lauric acid amidopropyl betaine, coconut oil fatty acid amidopropyl betaine, etc.) And sulfobetaine (such as lauryl hydroxysulfobetaine). Among them, the component (C) may contain one or more selected from betaine acetate, fatty acid amidopropyl betaine, N-lauroyl-N′-carboxymethyl-N′-hydroxyethylethylenediamine sodium, and imidazolinium betaine. Preferably, lauryldimethylaminoacetic acid betaine, coconut oil fatty acid amidopropyl betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and N-lauroyl-N′-carboxymethyl-N′-hydroxyethylethylenediamine sodium It is more preferable to contain 1 or more types selected from the above, and it is even more preferable to contain coconut oil fatty acid amidopropyl betaine.

  The method for producing the amphoteric surfactant is not particularly limited, and may be produced according to a known scheme. Specific examples of amphoteric surfactants include 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine (trade name Levon (registered trademark) 105) and N-lauroyl-N manufactured by Sanyo Chemical Industries, Ltd. '-Carboxymethyl-N'-hydroxyethylethylenediamine sodium (trade name Levon (registered trademark) 101-H), palm oil fatty acid amidopropyl betaine solution of EVONIK (trade name TEGO (registered trademark) Betain CK OK, palm oil fatty acid And 36 to 40% as amidopropyl betaine), a lauryldimethylaminoacetic acid betaine aqueous solution (trade name: NIKKOL (registered trademark) AM-301) manufactured by Nikko Chemicals. Specific examples of 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine include 2-coconut oil alkyl-N- sold by Lion Corporation under the trade name Enazicol (registered trademark) C-40H. Mention may also be made of an aqueous sodium carboxymethyl-N-hydroxyethylimidazolinium betaine solution.

  Component (C) may be one amphoteric surfactant or a combination of two or more amphoteric surfactants. Component (C) preferably contains a betaine amphoteric surfactant.

  The content of the component (C) is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, based on the total amount of the oral composition and the oral warming agent. More preferably, it is 1% by mass or more. Thereby, the discoloration suppression effect by (C) component can be exhibited. The upper limit of the content of component (C) is preferably 10% by mass or less, more preferably 5% by mass or less, and more preferably 2% by mass with respect to the total amount of the oral composition and the oral warming agent. Even more preferably: Thereby, irritation | stimulation in an oral mucosa can be suppressed and the fall of usability can be prevented. Therefore, the content of the component (C) is preferably 0.01% by mass to 10% by mass and more preferably 0.05% by mass to 5% with respect to the oral composition and the total amount of the warming agent for oral cavity. % By mass, and more preferably 0.1% by mass to 2% by mass.

<Form of oral composition and warming agent for oral cavity>
The dosage form and shape of the oral composition and oral warming agent of the present invention are not particularly limited. For example, liquid (solution, emulsion, suspension, etc.), semi-solid (gel, cream, paste, etc.), solid (Tablets, particulate agents, capsules, films, kneaded products, molten solids, waxy solids, elastic solids, etc.) can be prepared in any dosage form. Preferred dosage forms are liquid, semi-solid.

  Moreover, the prepared preparations include, for example, dentifrices (toothpaste, liquid dentifrice, liquid dentifrice, powder dentifrice, etc.), mouthwash, mouth freshener, oral application agent, oral patch, food (for example, Chewing gum, tablet confectionery, candy, gummi, film, troche, etc.) and the like, but it is not limited to the above as long as it is within the range of oral use. Among these, preferable preparations are dentifrice and mouthwash.

<Optional component>
In addition to the above components (A), (B) and (C), the oral composition and oral warming agent of the present invention include the components (A) and (B) as long as the effects of the present invention are not impaired. ) And (C) components other than the component and known additive components that can be used in the oral warming agent can be blended. Examples of such additional components include abrasives, binders, thickeners, surfactants other than component (C), sweeteners, preservatives, fragrances, medicinal ingredients, colorants, brighteners, pH adjusters. , Solvents and excipients, and may be appropriately selected depending on the dosage form. Although the specific example of an additional component is shown below, the component which can be mix | blended with the composition for oral cavity of this invention and an oral warming agent is not restrict | limited to these.

  Examples of the abrasive include silica-based abrasives such as silicic anhydride, crystalline silica, amorphous silica, silica gel, aluminosilicate, zeolite, calcium hydrogen phosphate anhydrous, calcium hydrogen phosphate dihydrate, Examples thereof include calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zirconium silicate, tertiary calcium phosphate, hydroxyapatite, tetracalcium phosphate, and a synthetic resin abrasive.

  An abrasive | polishing agent may be used individually by 1 type, and may use 2 or more types together. When mix | blending an abrasive | polishing agent, it is preferable that the compounding quantity is 2-40 mass% of the whole composition in a dentifrice, and it is more preferable that it is 5-20 mass%. In a mouthwash, it is preferable that it is 0-10 mass% of the whole composition, and it is more preferable that it is 0-5 mass%.

  Examples of the binder include pullulan, gelatin, methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, sodium carboxymethyl cellulose, carrageenan, sodium alginate, xanthan gum, sodium polyacrylate, gum arabic, guar gum, locust bean gum, polyvinyl alcohol, polyvinyl Examples thereof include organic binders such as pyrrolidone and carboxyvinyl polymer, and inorganic binders such as thickening silica and silicic anhydride. A binder may be used individually by 1 type, and may use 2 or more types together. When the binder is used, the amount is usually 0.01 to 15% by mass, preferably 0.01 to 13% by mass, based on the total amount of the oral composition and the oral warming agent. The compounding quantity of an organic binder is 0.01-5 mass% normally with respect to a composition for oral cavity and a warming agent for oral cavity, Preferably it is 0.01-3 mass%. The compounding quantity of an inorganic binder is 0.1-10 mass% normally with respect to a composition for oral cavity and a warming agent for oral cavity.

  Examples of the thickening agent (wetting agent) include sorbitol (sorbit), propylene glycol, butylene glycol, glycerin, polyethylene glycol and the like. A thickener may be used individually by 1 type and may use 2 or more types together. When the composition for oral cavity and the warming agent for oral cavity contain a thickener, the content thereof can be determined within a range not hindering the effects of the present invention, and the total amount of the oral composition and the warming agent for oral cavity is used. On the other hand, it is 1-60 mass% normally.

  As the surfactant other than the component (C), for example, an anionic surfactant, a nonionic surfactant and the like can be used.

  Examples of the anionic surfactant include N-acyl amino acid salts, α-olefin sulfonates, N-acyl sulfonates, alkyl sulfates, sulfates of glycerol fatty acid esters, and the like. The salt is preferably an alkali metal salt such as sodium salt or potassium salt, and sodium salt is particularly preferred. Of these, N-acylamino acid salts, α-olefin sulfonates, alkyl sulfates and the like are preferable from the viewpoint of versatility, and lauroyl sarcosine sodium, alkyl chain carbon chain length from the viewpoint of foamability and hard water resistance. More preferred are sodium α-olefin sulfonates having 10 to 16 carbon atoms, sodium lauryl sulfate and the like.

  Nonionic surfactants include, for example, polyoxyethylene alkyl ether, polyoxyethylene-polyoxypropylene block copolymer, polyoxyethylene hydrogenated castor oil, polyoxyethylene fatty acid glycerin ester, sucrose fatty acid ester, fatty acid alkylolamide Sorbitan fatty acid ester and its ethylene oxide adduct, glycerin fatty acid ester, polyglycerin fatty acid ester and the like. Of these, polyoxyethylene alkyl ether, polyoxyethylene hydrogenated castor oil, fatty acid alkylolamide, sorbitan fatty acid ester and an ethylene oxide adduct thereof are preferably used from the viewpoint of versatility. The polyoxyethylene alkyl ether preferably has a carbon chain length of 14 to 18 carbon atoms. The polyoxyethylene alkyl ether preferably has an average ethylene oxide addition mole number of 2 to 30. The polyoxyethylene hydrogenated castor oil preferably has an ethylene oxide average added mole number (average added EO) of 5 to 100. In the fatty acid alkylolamide, the fatty acid preferably has 8 to 18 carbon atoms, and the alkyl chain preferably has a carbon chain length of 2 to 4 carbon atoms. The sorbitan fatty acid ester preferably has 12 to 18 carbon atoms in the fatty acid. The polyoxyethylene sorbitan fatty acid ester preferably has 16 to 18 carbon atoms in the fatty acid. In addition, the polyoxyethylene sorbitan fatty acid ester preferably has an average ethylene oxide addition mole number of 10 to 40.

  (C) Surfactant other than a component may be used individually by 1 type, and may use 2 or more types together. When a composition for oral cavity and a warming agent for oral cavity contain surfactants other than (C) component, the content is normally 0-10 with respect to the composition for oral cavity and a warming agent for oral cavity. It is mass%, and it is preferable that it is 0.01-5 mass%.

  Examples of the sweetening agent include saccharin sodium, stevioside, neohesperidin dihydrochalcone, glycyrrhizin, perilartin, p-methoxycinnamic aldehyde, thaumatin, palatinose, maltitol, xylitol, arabitol and the like. A sweetener may be used individually by 1 type and may use 2 or more types together. When a sweetener is used, the blending amount can be appropriately determined within a range not impairing the effects of the present invention.

  Examples of the preservative include paraoxybenzoic acid esters such as sodium benzoate, methylparaben, ethylparaben, and butylparaben, and ethylenediaminetetraacetate. A preservative may be used individually by 1 type, and may use 2 or more types together. When the preservative is used, the blending amount can be appropriately determined within a range not impairing the effects of the present invention.

  Examples of the fragrances include natural fragrances, synthetic fragrances (single fragrances), and blended fragrances (oil and fat fragrances (oil-based fragrances), powder fragrances, etc.). A fragrance | flavor may be used individually by 1 type and may use 2 or more types together.

  Natural flavors include, for example, mastic oil, parsley oil, anise oil, eucalyptus oil, winter green oil, cassia oil, menthol oil, spearmint oil, peppermint oil, lemon oil, coriander oil, orange oil, mandarin oil, lime oil , Lavender oil, laurel oil, chamomile oil, cardamom oil, caraway oil, bay oil, lemongrass oil, pine needle oil, neroli oil, rose oil, jasmine oil, Iris concrete, peppermint absolute, rose absolute, orange flower, citrus Oil, mixed fruit oil, strawberry oil, cinnamon oil, clove oil, grape oil, clove oil, thyme oil, sage oil, peppermint oil, rosemary oil, marjoram oil, origanum oil, grapefruit oil, sweetie oil, palm oil, ma Go absolute, orange flower absolute, capsicum extract, ginger oleoresin, pepper oleoresin, and capsicum oleoresin and the like.

  Single flavors include, for example, carvone, anethole, methyl salicylate, cinnamaldehyde, linalool, linalyl acetate, limonene, menthone, menthyl acetate, pinene, octyl aldehyde, citral, pregon, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate Rate, allylcyclohexanepropionate, methylanthranilate, ethylmethylanthranilate, vanillin, undecalactone (γ-undecalactone, δ-undecalactone, etc.), hexanal (trans-2-hexenal, etc.), ethi Non-alcohol, propyl alcohol, butanol, isoamyl alcohol, hexenol (such as cis-3-hexenol), dimethylsulfide, cycloten, furfural, Limethylpyrazine, ethyl lactate, ethyl lioacetate, cineol (1,8-cineole, etc.), mensofuran, linalool oxide, vanillyl butyl ether, isopulegol, furaneol, ethylcyclopentenolone, 2-methylbutyric acid, propionic acid , Decalactone (γ-decalactone, δ-decalactone etc.), nonalactone (γ-nonalactone, δ-nonalactone etc.), hexalactone (γ-hexalactone, δ-hexalactone etc.), isoamyl acetate, benzaldehyde, hexyl acetate, ethyl- 2-methylbutyrate, benzyl alcohol, α-terpineol, phenylethyl glycidate, phenylethyl alcohol, allyl hexanoate, methyl cinnamate, ethyl β-methylthiopropionate, cis-6-nonenol, caron, methyl jasmonate, menthol, N-ethyl-p-menthane-3-carboxamide, N- (ethoxycarbonylmethyl) -3-p-menthane carboxamide , N, 2,3-trimethyl-2-isopropylbutanamide, 3- (L-methoxy) propane-1,2-diol, menthyl lactate (menthyl lactate), monomenthyl succinate, menthine glycerin acetal, 3-l-ment Examples thereof include xylpropane-1,2-diol, menthong glycerol ether, spiranthol, and monomenthyl succinate.

  The blended fragrance is a fragrance made by blending a single fragrance and / or a natural fragrance. Examples include menthol micron, mint flavor, strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, tropical fruit flavor, butter flavor, milk flavor, yogurt flavor, fruit mix flavor, herbal mint flavor, etc. .

  The form of the fragrance is not limited, and any of essential oil, extract, solid, and powder obtained by spray-drying any of these may be used. It is preferable that content of the fragrance | flavor raw material in the composition for oral cavity of this invention and an oral warming agent is 0.000001-1 mass% with respect to an oral composition and an oral warming agent whole quantity, respectively. Moreover, it is preferable that the total content as a fragrance | flavor for fragrance | flavor which uses the said fragrance | flavor raw material is 0.1-2.0 mass% with respect to the composition for oral cavity, and an oral warming agent whole quantity.

  Examples of medicinal components include the following components: caries preventive agents such as sodium fluoride, tin fluoride, sodium monofluorophosphate; chlorohexidine, triclosan, isopropylmethylphenol, cetylpyridinium chloride, benzethonium chloride, chloride Bactericidal or antibacterial agents such as benzalkonium, zinc gluconate and zinc citrate; anticalculus agents such as condensed phosphate and ethane hydroxydiphosphonate; coating agents such as hydroxyethylcellulose dimethyldiallylammonium chloride; vitamin C, chloride Astringents such as lysozyme and sodium chloride; hypersensitivity inhibitors such as strontium chloride, potassium nitrate and aluminum lactate. One medicinal component may be used alone, or two or more medicinal components may be used in combination. The compounding amount in the case of using a medicinal component can be appropriately set within a pharmaceutically acceptable range for each medicinal component.

  Examples of the colorant include natural pigments such as safflower red pigment, gardenia yellow pigment, gardenia blue pigment, perilla pigment, red potato pigment, red cabbage pigment, carrot pigment, hibiscus pigment, cacao pigment, spirulina pigment, and coumarindo pigment. Red 3, No. 104, Red No. 105, Red No. 106, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1 and other legal dyes, riboflavin, copper chlorofin sodium, titanium dioxide and the like. . When an oral composition and an oral warming agent contain a coloring agent, it is preferable that the content is 0.00001-3 mass% with respect to an oral composition and an oral warming agent whole quantity.

  Examples of the brightener include waxes such as shellac, carnauba wax, and candelilla wax, and calcium stearate. When the composition for oral cavity and the warming agent for oral cavity contain a brightener, the content thereof is preferably 0.01 to 5% by mass with respect to the total amount of the oral composition and warming agent for oral cavity.

  The pH (20 ° C.) of the oral composition and oral warming agent of the present invention is usually 6.5 to 9, preferably 7 to 8.5. Examples of the pH adjuster include acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, succinic acid, glutamic acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, Examples include acids and alkalis such as sodium citrate, sodium hydrogen citrate, sodium phosphate, and sodium dihydrogen phosphate, and buffers. When a pH adjuster is blended, the blending amount can be appropriately determined within a range not impairing the effects of the present invention.

  Examples of the solvent include water and lower alcohols having 3 or less carbon atoms such as ethanol and propanol. When an oral composition and an oral warming agent contain water as a solvent, it is preferable that the content is 20-95 mass% with respect to an oral composition and an oral warming agent whole quantity. When the oral composition and oral warming agent contain a lower alcohol as a solvent, the content is preferably 1 to 30% by mass with respect to the total amount of oral composition and oral warming agent.

  Examples of the excipient include syrup, glucose, fructose, invert sugar, dextrin, oligosaccharide and the like. When the oral composition and the oral warming agent are solid preparations, an excipient is usually added. When the excipient is blended, the blending amount can be appropriately determined within a range not impairing the effects of the present invention.

  EXAMPLES The present invention will be specifically described below with reference to examples, but the present invention is not limited to such examples. In the following, “%” means “mass%” unless otherwise specified.

Examples 1-15 and Comparative Examples 1-3
A dentifrice composition was prepared by the following preparation method according to the blending amounts shown in Tables 1 to 3. In addition, the compounding quantity of each component shown to Tables 1-3 is the value (AI) converted into a pure part.

(Method for preparing dentifrice composition)
Dissolve sodium fluoride, sorbite solution, glycerin, saccharin sodium, viscosity modifier (silicic anhydride), pyrrolidone carboxylic acid Na (component (A)), hesperidin (component (B)) in purified water, Prepared. Separately, sodium alginate, xanthan gum, sodium polyacrylate, and preservatives (methyl paraben and butyl paraben) were dispersed in propylene glycol to prepare liquid Y. Next, liquid Y was added to liquid X and stirred. Then, mint flavor, abrasive (silicic anhydride), sodium lauryl sulfate, polyoxyethylene hydrogenated castor oil, and coconut oil fatty acid amidopropyl betaine (component (C)) are added and further stirred under reduced pressure (pressure 4 kPa). Thus, a dentifrice composition (toothpaste) was obtained. A 1.5 L capacity kneader (manufactured by Ishiyama Institute) was used for the production.

The detail of the component used for preparation of a dentifrice composition is shown below.
<(A) component>
Sodium pyrrolidone carboxylate: “AJIDEW (registered trademark) N-50, PCA soda (AI = 50% aqueous solution)” manufactured by Ajinomoto Healthy Supply Co., Ltd.

<(B) component>
Hesperidin: “Hayashibara Hesperidin (registered trademark) S” manufactured by Hayashibara Co., Ltd.

<(C) component>
Coconut oil fatty acid amidopropyl betaine solution: EVONIK, AI = 37%

  The other components used were those conforming to the Quasi-drug raw material standard 2006.

  Each dentifrice composition was evaluated as follows, and the evaluation results are shown in Tables 1 to 3.

(Evaluation method)
(1) Feeling of temperature at the back of the gum and / or root surface when brushing teeth 10 subjects used each dentifrice composition, and reaching the depth and root surface of the gum during brushing I investigated the feeling of feeling. About 1 g of the dentifrice composition was put on a toothbrush, and the degree of the sense of ultimate temperature when brushing for 3 minutes was asked to each subject in any of the following four stages (i) to (iv). The score shown below was given to each of the four stages, and the average score of 10 subjects for each dentifrice composition was calculated. The average score of 10 test subjects was classified into the following four grades (A) to (X), and the actual feeling of feeling of temperature reached was evaluated.

[Degree of feeling of arrival temperature]
(I) Strong feeling of entering the back and root surfaces of the gums ... 4 points (ii) Feeling of entering the back and root surfaces of the gums ... 3 points (iii) Back and root surfaces of the gums 2 points (iv) No feeling of entering the part of the gums or 1 part of the root surface.

[Evaluation criteria for average score]
◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average point 1.0 points More than 2.0 points

(2) Evaluation of foaming property Ten subjects used each dentifrice composition, and investigated the foaming property of the dentifrice composition at the time of toothpaste. About 1 g of the dentifrice composition was put on a toothbrush and the degree of foaming when brushing for 3 minutes was asked to each subject in any of the following four stages (i) to (iv). The score shown below was given to each of the four stages, and the average score of 10 subjects for each dentifrice composition was calculated. The average score of 10 subjects was classified into the following four grades (A) to (X), and the foaming property was evaluated.

[Degree of foaming property]
(I) Feeling foaming strongly ... 4 points (ii) Feeling foaming ... 3 points (iii) Feeling almost no foaming ... 2 points (iv) Feeling no foaming ... 1 point

[Evaluation criteria for average score]
◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average point 1.0 points More than 2.0 points

(3) Discoloration evaluation at high temperature The dentifrice composition was filled in a tube and stored at 60 ° C. for 1 month, and then a length of 5 cm was taken out from the tube on a sheet of paper, and visually evaluated according to the following criteria.

[Evaluation criteria for discoloration]
A: No discoloration is observed. ○: A slight discoloration is observed. Δ: Some discoloration is observed. X: Discoloration is recognized.

  From Tables 1 to 3, the following can be understood. The dentifrice composition of Comparative Example 1 that does not contain the component (A) and the dentifrice composition of Comparative Example 2 that does not contain the component (B) were inferior in the sense of reaching temperature, but Examples 1 to 15 The dentifrice composition of was excellent in feeling of ultimate temperature. Furthermore, the dentifrice composition of Comparative Example 2 containing no component (B) was inferior in foaming properties, whereas the dentifrice compositions in Examples 1 to 15 were excellent in foaming properties. The dentifrice composition of Comparative Example 3 containing no component (C) has a significant discoloration after storage at high temperatures, whereas the dentifrice compositions of Examples 1 to 15 containing component (C) are stored at high temperatures. Later discoloration was suppressed. These results show that the oral composition and oral warming agent of the present invention are excellent in feeling of reaching temperature, are excellent in foaming properties, and discoloration after storage is suppressed.

Claims (4)

(A) component: 0.1-10 mass% of pyrrolidone carboxylic acid and / or its salt,
(B) component: Hesperidin and / or its sugar adduct 0.2-10 mass% ,
(C) component: Fatty acid amidopropyl betaine 0.01-10 mass% ,
The composition for oral cavity containing this. (A) component: 0.3-8 mass% of pyrrolidone carboxylic acid and / or its salt,
(B) component: Hesperidin and / or its sugar adduct 0.2-5 mass%,
(C) component: 0.05-10 mass% of fatty acid amidopropyl betaine,
The composition for oral cavity containing this. (A) component: 0.5-6 mass% of pyrrolidone carboxylic acid and / or its salt,
(B) component: Hesperidin and / or its sugar adduct 0.2-3 mass%,
(C) component: 0.1-10 mass% of fatty acid amidopropyl betaine,
The composition for oral cavity containing this. (A) component: 0.5-6 mass% of pyrrolidone carboxylic acid and / or its salt,
(B) component: Hesperidin and / or its sugar adduct 0.2-3 mass% ,
(C) component: 0.1-10 mass% of fatty acid amidopropyl betaine ,
Oral warming agent containing