JP7660480B2 - Non-aqueous oral composition - Google Patents

Description

The present invention relates to a non-aqueous oral composition.

A known method for imparting a warming sensation to dentifrice is to use a solvent other than water and impart a warming sensation to the dentifrice by the heat of hydration of the solvent.

For example, Patent Document 1 describes that by incorporating a cooling agent into a polyhydric alcohol-based dentifrice composition containing a specific combination of surfactants, it is possible to provide a noticeable cooling sensation after use in addition to a warming sensation. Patent Document 2 describes that an oral care composition composed of a flavor composition containing tin ions, a mint-type flavor oil, and a specific protective agent component can suppress unpleasant sensations such as bad odor and bad taste caused by tin ions.

On the other hand, heliotropin (piperonal) is used as a fragrance and is known to have autonomic nervous system regulating effects, sleep improving effects, and stress relieving effects (Patent Documents 3 and 4).

JP 2021-31426 A JP 2013-32371 A JP 2010-90317 A JP 2007-197334 A

However, although the warming sensation caused by the heat of hydration of the solvent is felt strongly at the beginning of brushing, the warming sensation may not last long, and may not be sufficiently improved even if a cooling agent is added as in Patent Documents 1 and 2. In addition, although heliotropin is known to be a fragrance having a physiological effect, it is not known to be involved in imparting a warming sensation.
The present invention has been made in consideration of the above, and aims to provide a non-aqueous oral composition that provides a good sense of use by providing a long-lasting warming sensation during use and reducing unpleasant bitterness and sweetness.

In order to solve the above problems and achieve the object, the present invention is characterized by the following [1] to [8].
[1] (A) A non-aqueous oral composition containing heliotropin and having a moisture content of 2% by mass or less.
[2] The non-aqueous oral composition according to [1], wherein the content of component (A) is 0.01 to 0.5 mass%.
[3] (B) A non-aqueous oral composition described in [1] or [2], further containing at least one polyhydric alcohol selected from glycerin, polyethylene glycol, propylene glycol, and 1,3-butylene glycol.
[4] The component (B) is
(B1) glycerin,
(B2) The non-aqueous oral composition described in [3], which is a combination of at least one selected from polyethylene glycol, propylene glycol, and 1,3-butylene glycol.
[5] The non-aqueous oral composition according to [4], wherein the (B2) component contains at least polyethylene glycol.
[6] The non-aqueous oral composition according to any one of [3] to [5], wherein the content of the (B) component is 20 to 85 mass%.
[7] The non-aqueous oral composition according to any one of [4] to [6], wherein the mass ratio (B1/B2) of the content of the (B1) component to the content of the (B2) component is 0.5 to 20.
[8] The non-aqueous oral composition according to any one of [1] to [7], which is a toothpaste composition.

The present invention provides a non-aqueous oral composition that provides a long-lasting warming sensation when brushing teeth, has no unpleasant bitter or sweet taste, and is easy to use.

The present invention is described in detail below.

[1. Oral composition]
The composition contains the component (A) and preferably further contains the component (B).

(A) Heliotropin
The component (A) is heliotropin. The origin of heliotropin is not particularly limited, and it may be naturally derived from microorganisms, plants, animals, etc., or may be artificially prepared by genetic recombination, chemical synthesis, etc. In the case of natural origin, the purity is not particularly limited, and those containing components other than heliotropin, such as essential oils and plant extracts, may be used as the component (A).

The content of component (A) is preferably 0.008% by mass or more, more preferably 0.01% by mass or more, based on the total amount of the composition. This can further improve the sustained warmth sensation. The upper limit is preferably 0.8% by mass or less, more preferably 0.5% by mass or less. This can prevent the unique sweetness of heliotropin from affecting the usability of the non-aqueous oral composition. Therefore, the content of component (A) is preferably 0.008 to 0.8% by mass, more preferably 0.01 to 0.5% by mass.

[(B) Polyhydric alcohol]
The component (B) is a polyhydric alcohol. The polyhydric alcohol is usually a polyhydric alcohol that is liquid at 25°C and generates heat of hydration when it comes into contact with water. The polyhydric alcohol as the component (B) is, for example, glycerin, polyethylene glycol, propylene glycol, 1,3-butylene glycol, diglycerin, polypropylene glycol, or a combination of two or more selected from these, and glycerin, polyethylene glycol, propylene glycol, 1,3-butylene glycol, or a combination of two or more selected from these is preferred, and a combination of two or more is more preferred. As a combination of two or more, a combination containing glycerin is preferred, and a combination of (B1) glycerin and (B2) at least one or more selected from polyethylene glycol, propylene glycol, and 1,3-butylene glycol is more preferred. In the above combination of (B1) and (B2), it is preferred that (B2) contains at least polyethylene glycol.

-Glycerin-
Polyhydric alcohols usually have a bitter taste, but glycerin has a relatively weak bitter taste, and therefore, by including at least glycerin in component (B), the bitter taste of the composition can be suppressed.

-Average molecular weight of polyethylene glycol-
The average molecular weight of the polyethylene glycol (average molecular weight as described in the Quasi-Drug Raw Materials Standards 2006, the same applies below) is preferably 190 to 630. Polyethylene glycols with the above average molecular weight contribute relatively strongly to the sensation of warmth, and can increase the intensity of the sensation of warmth. Examples of such polyethylene glycols include polyethylene glycol 200 (average molecular weight 190 to 210), polyethylene glycol 400 (average molecular weight 380 to 420), and polyethylene glycol 600 (average molecular weight 570 to 630).

--Content of (B)--
The content of the (B) component is preferably 20% by mass or more, more preferably 30% by mass or more, based on the total amount of the composition. This allows a warm feeling to be obtained during use, and a good moist feeling to be obtained. The upper limit is preferably 85% by mass or less, more preferably 80% by mass or less. This prevents a decrease in viscosity, and allows good usability to be exhibited. Therefore, the content of the (B) component is preferably 20 to 85% by mass, more preferably 20 to 80% by mass, and even more preferably 30 to 80% by mass.

[B1/B2]
When the component (B) is a combination of the components (B1) and (B2), the ratio of the content of the component (B1) to the content of the component (B2) (B1/B2) is preferably 0.5 or more, more preferably 1 or more, and the upper limit is preferably 20 or less, more preferably 18 or less, even more preferably 14 or less, and even more preferably 12 or less. Therefore, B1/B2 is preferably 0.5 to 20, more preferably 0.5 to 18, even more preferably 1 to 14, and even more preferably 1 to 12.

[Non-aqueous]
The composition is a non-aqueous oral composition. In this specification, non-aqueous means that it does not substantially contain water, and it is preferable that water is not intentionally added in the manufacturing process of the oral composition, and that it contains only water in the raw materials. The water content in the non-aqueous oral composition is usually 2% by mass or less, preferably 1% by mass or less, and more preferably 0.5% by mass or less. The water content of the oral composition can be calculated as the ratio (mass%) of the total water content contained in the raw materials before blending to the total raw materials, or as the ratio (mass%) of the difference between the weight after drying and the weight before drying of the oral composition to the weight before drying.

[Optional components]
The non-aqueous oral composition may contain other components in addition to the components (A) and (B) to the extent that the effect of the present invention is not impaired. Examples of other components include, but are not limited to, components that can be blended into oral compositions, such as surfactants, sweeteners, flavorings, humectants, binders, abrasives, pH adjusters, preservatives, medicinal components, oily components, and colorants (pigments).

-Surfactants-
Examples of the surfactant include anionic surfactants, amphoteric surfactants, and nonionic surfactants. Since the surfactants can further improve the onset of the warming sensation, anionic surfactants and amphoteric surfactants are preferred, and anionic surfactants are more preferred.

Examples of anionic surfactants include alkyl sulfates, acyl amino acid salts, acyltaurine salts, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, and lauryl sulfoacetates. The alkyl and acyl groups may be either linear or branched, and may be either saturated or unsaturated, and the number of carbon atoms is usually 10 to 20, preferably 12 to 18, and more preferably 14 to 16. The salt may be selected from pharmacologically acceptable salts. Examples of pharmacologically acceptable salts include base addition salts and amino acid salts. Specific examples of such salts include inorganic base salts such as sodium salts, potassium salts, calcium salts, magnesium salts, and ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts, and diisopropylammonium salts; and basic amino acid salts such as arginine salts. Among these, inorganic base salts are preferred, alkali metal salts (e.g., sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

Examples of alkyl sulfates include lauryl sulfate and myristoyl sulfate. Examples of acylamino acid salts include acyl sarcosine salts such as lauroyl sarcosine salt and myristoyl sarcosine salt; acyl glutamate salts such as lauroyl glutamate, myristoyl glutamate and palmitoyl glutamate; acyl glycine salts such as N-lauroyl-N-methyl glycine salt and cocoyl glycine salt; acyl alanine salts such as N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl-N-methyl-β-alanine salt and N-methyl-N-acylalanine salt; and acyl aspartate salts such as lauroyl aspartate. Examples of acyltaurate salts include lauroyl methyl taurate salt, N-methyl-N-acyltaurate salt, and N-cocoyl methyl taurate salt. Examples of α-olefin sulfonate salts include α-olefin sulfonate salts having 12 to 18 carbon atoms, such as tetradecene sulfonate salts (α-olefin sulfonic acid having 14 to 16 carbon atoms). Other examples of anionic surfactants include hydrogenated sodium coconut fatty acid monoglyceride monosulfate and sodium lauryl sulfoacetate.

As the anionic surfactant, α-olefin sulfonate is preferred, and tetradecene sulfonate (α-olefin sulfonic acid having 14 to 16 carbon atoms) is more preferred. The anionic surfactant may be one type or a combination of two or more types.

When an anionic surfactant is included, its content is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, of the entire composition. This improves the dispersibility of the formulation in the oral cavity during use, and improves the onset of the warming sensation. The upper limit is preferably 3% by mass or less, more preferably 2% by mass or less. This reduces the feeling of degreasing in the oral cavity after use. Therefore, it is preferably 0.1 to 3% by mass, more preferably 0.5 to 2% by mass, of the entire composition.

Examples of amphoteric surfactants include betaine type and amino acid type, with betaine type being preferred. Examples of betaine type amphoteric surfactants include fatty acid amidopropyl betaine (e.g., coconut oil fatty acid amidopropyl betaine), alkyl acetate betaine (e.g., alkylamino acetate betaine such as lauryl dimethylamino acetate betaine), and alkyl imidazolinium betaine (e.g., alkyl carboxymethyl hydroxyethyl imidazolinium betaine), with fatty acid amidopropyl betaine and alkyl acetate betaine being preferred, and coconut oil fatty acid amidopropyl betaine being more preferred. When the amphoteric surfactant has an alkyl group or an acyl group, they may be either linear or branched, and may be either saturated or unsaturated, and the number of carbon atoms is usually 10 to 20, preferably 12 to 18, and more preferably 14 to 16. The amphoteric surfactant is preferably a solution or powder with a pure content (betaine pure content) of 65% or more. This makes it easier to adjust the moisture content of the composition.

As the amphoteric surfactant, fatty acid amidoalkyl betaine is preferable, and fatty acid amidopropyl betaine such as coconut oil fatty acid amidopropyl betaine is more preferable. The amphoteric surfactant may be one type or a combination of two or more types.

When an amphoteric surfactant is included, its content is preferably 0.1% by mass or more, more preferably 0.3% by mass or more, of the entire composition. This sufficiently improves the degreasing sensation in the oral cavity and improves the onset of the warming sensation. The upper limit is preferably 3% by mass or less, more preferably 2% by mass or less. This suppresses bitterness and allows the pleasant taste to be sufficiently maintained. Therefore, 0.1 to 3% by mass is preferable, and 0.3 to 2% by mass is more preferable.

Examples of nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate), alkylolamides, polyoxyethylene fatty acid esters, polyoxyethylene alkenyl ethers, glycerin fatty acid esters, sucrose fatty acid esters (e.g., maltose fatty acid esters), sugar alcohol fatty acid esters (e.g., maltitol fatty acid esters, lactitol fatty acid esters), fatty acid diethanolamides (e.g., lauric acid mono- or diethanolamide), polyoxyethylene polyoxypropylene copolymers, polyoxyethylene polyoxypropylene fatty acid esters, polyoxyethylene polyoxypropylene (EOPO) copolymers, alkyl glucosides, and fatty acid polyglyceryls. The number of carbon atoms in the alkyl group of the polyoxyethylene alkyl ether is usually 12 to 18, preferably 14 to 18 (e.g., lauryl and stearyl groups), and the average number of moles of ethylene oxide added is usually 5 to 30, preferably 15 to 30. The average number of moles of ethylene oxide added to polyoxyethylene hydrogenated castor oil is usually 5 to 100 moles, preferably 20 to 100 moles, more preferably 20 to 60 moles. The number of carbon atoms in the fatty acid of the sorbitan fatty acid ester is usually 12 to 18. The number of carbon atoms in the fatty acid of the polyoxyethylene sorbitan fatty acid ester is usually 16 to 18, and the average number of moles of ethylene oxide added is usually 10 to 40 moles. The number of carbon atoms in the alkyl chain of the alkylolamide is usually 12 to 14. The polyoxyethylene polyoxypropylene (EOPO) copolymer preferably has an average number of moles of ethylene oxide added of 20 to 210 and an average number of moles of propylene oxide added of 15 to 60, and may be a block copolymer or a random copolymer.

When a nonionic surfactant is included, its content is preferably 0.05% by mass or more, more preferably 0.5% by mass or more, of the entire composition. This leads to a good improvement in the degreasing sensation in the oral cavity. The upper limit is preferably 2% by mass or less, more preferably 1% by mass or less. This allows the bitterness to be suppressed and a pleasant taste to be sufficiently maintained. Therefore, the content is preferably 0.05 to 2% by mass, more preferably 0.5 to 1% by mass.

-Sweetener-
Examples of sweeteners include xylitol, erythritol, maltitol, saccharin, saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartine, glycyrrhizin, thaumatin, aspartyl phenylalanine methyl ester, and p-methoxycinnamic aldehyde. The sweeteners may be used alone or in combination of two or more.

-Fragrance-
Fragrances include peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime oil, lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, and absinthe. Natural fragrances such as lute peppermint, absolute rose, orange flower, and processed fragrances (front distillation, back distillation, liquid-liquid extraction, essences, powdered fragrances, etc.) of these natural fragrances, as well as menthol, carvone, anethole, cineole, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-menthoxypropane-1.2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl Acetate, N-substituted-paramenthane-3-carboxamide, pinene, octylaldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methylphenyl glycidate, vanillin, undecalactone, hexanal, propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, ethyl thioacetate, and other single flavors, as well as blended flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, and tropical fruit flavor, and other known flavor materials used in oral compositions can be used. The flavors may be used alone or in combination of two or more.
The above-mentioned flavor materials are preferably used in an amount of 0.000001 to 1% by mass in the composition, and the flavorings using the above-mentioned flavor materials are preferably used in an amount of 0.1 to 2.0% by mass in the composition.

- Wetting agent -
Examples of the wetting agent include sugar alcohols. Examples of the sugar alcohol include sorbitol and lactitol. The wetting agent may be one type or a combination of two or more types. The average molecular weight is the average molecular weight described in the Quasi-Drug Raw Materials Standards 2006. The content of the wetting agent is usually 0 to 20% by mass, preferably 1 to 10% by mass.

- Binding agent -
The binder may be an organic binder such as a water-soluble polymer, or an inorganic binder. Examples of the organic binder include cellulose-based binders (e.g., carboxymethylcellulose (CMC), its sodium salt, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, cationic cellulose, etc.), other polysaccharide-based binders (e.g., xanthan gum, guar gum, gellan gum, tragacanth gum, karaya gum, arabic gum, locust bean gum, carrageenan, sodium alginate), and synthetic water-soluble polymers (e.g., (crosslinked) sodium polyacrylate, carboxyvinyl polymer, polyvinyl alcohol, propylene glycol alginate). Examples of the inorganic binder include thickening silica such as precipitated silica, pyrogenic silica, gelling silica, gelling aluminum silica, and clay minerals such as veegum, laponite, and bentonite. Organic binders are preferred, cellulose-based binders and other polysaccharide-based thickeners are more preferred, and sodium carboxymethylcellulose and carrageenan are even more preferred. The binder may be one type or a combination of two or more types, and a combination of two or more types (for example, a combination of a cellulose-based binder and another polysaccharide-based thickener) is preferred.
The content of the binder is preferably 0.1 to 3 mass %, and more preferably 0.1 to 2 mass %, of the entire composition.

- Abrasives -
The abrasive may be, for example, either inorganic abrasive or organic abrasive.The inorganic abrasive may be, for example, abrasive silica such as aluminosilicate, zirconosilicate, crystalline zirconium silicate, titanium-bonded silica, etc.; calcium phosphate-based compounds such as calcium diphosphate dihydrate or anhydrous, calcium monophosphate, calcium triphosphate, calcium pyrophosphate, etc.; calcium carbonate-based abrasive such as calcium carbonate; calcium-based abrasives other than carbonate/phosphate such as calcium hydroxide and calcium sulfate; aluminum-based materials such as aluminum oxide, aluminum hydroxide, and alumina; silicic acid-based materials such as anhydrous silicic acid, zeolite, and zirconium silicate; magnesium-based materials such as magnesium carbonate and magnesium triphosphate; apatite-based materials such as hydroxyapatite, fluoroapatite, and calcium-deficient apatite; titanium-based materials such as titanium dioxide, titanium mica, and titanium oxide; and minerals such as bentonite.The organic abrasive may be, for example, polymethyl methacrylate and synthetic resin-based abrasives. Among these, abrasive silica and calcium phosphate compounds are preferred, and silicic anhydride is more preferred. The abrasive may be used alone or in combination of two or more.
The amount of the abrasive blended is usually 0 to 70% by mass, preferably 2 to 30% by mass, of the entire composition.

- pH adjuster -
Examples of pH adjusters include organic acids or salts thereof such as phthalic acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, and lactic acid, inorganic acids or salts thereof (e.g., potassium salts, sodium salts, and ammonium salts) such as phosphoric acid (orthophosphoric acid), and hydroxides such as sodium hydroxide and potassium hydroxide. Examples of inorganic acid salts include disodium hydrogen phosphate and sodium dihydrogen phosphate.

- Preservatives -
Examples of preservatives include paraoxybenzoic acid esters (e.g., methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate), sodium benzoate, etc. The preservatives may be used alone or in combination of two or more kinds.

-Medicinal ingredients-
Examples of medicinal ingredients include bactericidal or antibacterial agents such as nonionic bactericides (e.g., isopropylmethylphenol), cationic bactericides (e.g., cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride), zinc gluconate, zinc citrate, triclosan, hinokitiol, lysozyme chloride, chlorhexidine salts, and trichlorocarbanilide; enzymes such as dextranase, mutanase, amylase, protease, retic enzyme, and coenzyme Q10; sodium fluoride and sodium monofluorophosphate. anti-inflammatory agents such as ε-aminocaproic acid, allantoins (e.g., allantoin, allantoin chlorhydroxyaluminum), tranexamic acid, azulene, dihydrocholesterol, α-bisabolol, glycyrrhizin, glycyrrhetinic acid, berberine, epidihydrocholesterol, and the like; metal salts such as zinc, copper salts, tin salts, and the like; water-soluble phosphate compounds such as potassium salts and sodium salts of orthophosphoric acid; chelating phosphate compounds such as glycerophosphate, and the like; condensed phosphates, ethanehydroxydiphosphate, and the like; anti-tartar agents such as phonates; blood flow promoters such as vitamin E (e.g., tocopherol acetate such as dl-α-tocopherol acetate); hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, strontium chloride, etc.; coating agents such as hydroxyethylcellulose dimethyl diallyl ammonium chloride; astringents such as vitamin C (e.g., ascorbic acid or a salt thereof), sodium chloride, etc.; copper compounds such as copper chlorophyll, copper gluconate, etc.; anti-tartar agents, amino acids such as alanine, glycine, proline, etc.; Angelica acutiloba soft extract , Phellodendron bark extract, chamomile, clove, rosemary, Scutellaria root, safflower, thyme, Scutellaria root, clove, Hamamelis, etc. plant extracts; callopeptide, polyvinylpyrrolidone, hydroxamic acid and its derivatives, tripolyphosphate, methoxyethylene maleic anhydride copolymer, sodium chloride, chlorophyll, sanguinarine extract, berberine, hydroxamic acid and its derivatives, pyrophosphate, zeolite, epidihydrocholesterol, trichlorocarbanilide, zinc citrate. The medicinal ingredient may be used alone or in combination of two or more. The content of the medicinal ingredient can be appropriately set to an effective amount according to a conventional method within a range that does not interfere with the effects of the present invention.

-Oily ingredients-
Examples of oily components include hydrocarbons such as squalane, liquid paraffin, petrolatum, microcrystalline wax, carnauba wax, rice wax, and rosin; higher alcohols (e.g., alcohols having 8 to 22 carbon atoms, such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, and isostearyl alcohol); higher fatty acids (e.g., fatty acids having 8 to 22 carbon atoms, such as lauric acid, myristic acid, oleic acid, and isostearic acid), vegetable oils such as olive oil, castor oil, and coconut oil; and fatty acid esters such as isopropyl myristate.

- Coloring agent -
The non-aqueous oral composition of the present embodiment may contain any suitable coloring agent known in the art in any suitable amount. Examples of the coloring agent that may be contained in the non-aqueous oral composition include natural coloring agents such as safflower red coloring agent, gardenia yellow coloring agent, gardenia blue coloring agent, perilla coloring agent, red koji coloring agent, red cabbage coloring agent, carrot coloring agent, hibiscus coloring agent, cacao coloring agent, spirulina blue coloring agent, and tamarind coloring agent, legal coloring agents such as Red No. 2, Red No. 3, Red No. 104, Red No. 105, Red No. 106, Red No. 227, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1, and Blue No. 4, riboflavin, and sodium copper chlorophyllin.
When the non-aqueous oral composition contains a colorant, the content thereof is preferably 0.00001 to 3 mass % based on the total mass of the non-aqueous oral composition.

The non-aqueous oral composition can be used as a dentifrices such as toothpaste, gel dentifrice, liquid dentifrice, liquid dentifrice, and powder dentifrice, and is preferably a toothpaste.

The dosage form of the non-aqueous oral composition can be appropriately selected depending on the form of use, and is not particularly limited. Examples of dosage forms include gel and paste.

[Method for producing non-aqueous oral composition]
The method of producing the non-aqueous oral composition is not particularly limited, and it can be prepared by a conventional method according to the dosage form. For example, when used as a toothpaste, the method includes preparing the components that dissolve in the solvent, mixing the other insoluble components, and degassing (e.g., reducing pressure, etc.) as necessary. The toothpaste obtained can be put into a container to make a product. The shape and material of the container are not particularly limited, and the container used for a conventional toothpaste composition can be used, for example, a plastic container such as polyethylene, polypropylene, polyethylene terephthalate, nylon, etc.

The present invention will be specifically explained below with reference to examples and comparative examples, but the present invention is not limited to the following examples. Note that % in the table indicates mass % unless otherwise specified.

[Main raw materials used in the examples and comparative examples]
(A) Heliotropin: manufactured by Takasago International Corporation (B1) Concentrated glycerin (99.5%): Concentrated glycerin for cosmetics manufactured by Sakamoto Pharmaceutical Industries, Ltd. (B2-1) Polyethylene glycol 400: Polyethylene glycol 400 manufactured by Sanyo Chemical Industries, Ltd.
(B2-2) Propylene glycol: manufactured by ADEKA Corporation (B2-3) 1,3-butylene glycol: manufactured by Kokyu Alcohol Kogyo Co., Ltd. (components other than (A) and (B-1))
Sodium tetradecene sulfonate: K-Liporan PJ-400CJ, manufactured by Lion Specialty Chemicals
Coconut oil fatty acid amidopropyl betaine: Evonik Co., Ltd., TEGO Betaine CK D, product composition (coconut oil fatty acid amidopropyl betaine: sodium chloride: water = 85: 14.5: 0.5, betaine pure content 85%)
Sodium monofluorophosphate: manufactured by ICL JAPAN Sodium saccharin: manufactured by Aisan Chemical Industry Co., Ltd. Silica: manufactured by Solvay, Tixosil (registered trademark) 73 (average particle size (volume basis D50): 9 μm)
Carrageenan: GENUVISCO (registered trademark) carrageenan type TPC-1, manufactured by CPKelco
Sodium carboxymethylcellulose: Daicel FineChem Co., Ltd., CMC1260
Other ingredients used were those that conformed to the Standards for Quasi-Drug Ingredients 2006.

Examples 1 to 9 and Comparative Examples 1 to 3 (Toothpaste)
Dentifrice compositions were prepared according to the following preparation method. The blending compositions of each example are shown in Tables 1 to 5 (units in the tables: mass %). The moisture content of the composition was calculated as the ratio (mass %) of the total moisture content contained in the raw materials before blending to the total amount of the raw materials, and was 2 mass % or less in all cases.

[Method of preparing a dentifrice composition]
The raw materials were blended in a conventional manner, mixed at room temperature using a 1.5 L kneader (manufactured by Ishiyama Kosakusho Co., Ltd.), and degassed under reduced pressure (pressure 4 kPa) to obtain a dentifrice composition.

[Evaluation method]
The obtained dentifrice compositions were subjected to the following evaluations.

- Evaluation of sustained warmth sensation while brushing teeth -
1 g of the dentifrice composition was placed on a toothbrush (Clinica Advantage toothbrush, 4-row compact regular, manufactured by Lion Corporation; the same applies to the toothbrush used in the following evaluation method), and the toothbrush was brushed in the usual manner. The feeling of the sustained warmth was evaluated on a 5-point scale according to the following rating scale. The average scores of the 7 testers were calculated, and are shown in the table with ◎, ○, △, and × according to the following rating scale.

(Rating criteria)
5 points: Feeling that the warmth lasts for a long time (more than 15 seconds after the warmth begins to be felt)
4 points: The warm sensation lasts for a long time (10 to 15 seconds after the warm sensation begins)
3 points: The warm sensation continues (5 to 10 seconds after the warm sensation begins)
2 points: A slight warm sensation continues (2 to 5 seconds after the warm sensation begins)
1 point: No sense of continued warmth at all (less than 2 seconds from the start of feeling the warmth or no sense of warmth at all)
(Score)
◎: Average of 4.5 points or more ○: Average of 4.0 points or more and less than 4.5 points △: Average of 3.0 points or more and less than 4.0 points ×: Average of 1.0 points or more and less than 3.0 points

- Evaluation of unpleasant bitterness and lack of sweetness when brushing teeth -
The absence of unpleasant bitterness or sweetness when 1 g of the dentifrice composition was applied to a toothbrush and brushed in the usual manner was evaluated on a 5-point scale according to the following rating scale. The average scores of the seven testers were calculated and shown in the table as ◎, ○, △, and × according to the following rating scale.

(Evaluation Criteria)
5 points: No unpleasant bitterness or sweetness at all 4 points: Slight bitterness or sweetness is felt, but not unpleasant 3 points: Bitterness or sweetness is felt, and it is slightly unpleasant 2 points: Unpleasant bitterness or sweetness is felt 1 point: Strong unpleasant bitterness or sweetness is felt
(Score)
◎: Average of 4.5 points or more ○: Average of 4.0 points or more and less than 4.5 points △: Average of 3.0 points or more and less than 4.0 points ×: Average of 1.0 points or more and less than 3.0 points

[Table Notes]
*: No warmth felt

In comparison with the Comparative Examples, the dentifrices of Examples 1 to 9, which contained heliotropin and had a moisture content of 2% by mass or less, were excellent in both the sustained warmth felt when brushing teeth and the absence of unpleasant bitterness or sweetness.
These results show that according to the present invention, the unpleasant bitter and sweet tastes experienced when brushing teeth can be suppressed and the warming sensation can be maintained for a long period of time.

Claims (8)

(A) A non-aqueous oral composition containing heliotropin and having a water content of 2% by mass or less. The non-aqueous oral composition according to claim 1, wherein the content of component (A) is 0.01 to 0.5% by mass. The non-aqueous oral composition according to claim 1 or 2, further comprising (B) at least one polyhydric alcohol selected from glycerin, polyethylene glycol, propylene glycol, and 1,3-butylene glycol. The component (B) is
(B1) glycerin,
The non-aqueous oral composition according to claim 3, which is a combination of at least one selected from (B2) polyethylene glycol, propylene glycol, and 1,3-butylene glycol. The non-aqueous oral composition according to claim 4, wherein component (B2) contains at least polyethylene glycol. The non-aqueous oral composition according to any one of claims 3 to 5, wherein the content of component (B) is 20 to 85 mass %. The non-aqueous oral composition according to any one of claims 4 to 6, wherein the mass ratio (B1/B2) of the content of component (B1) to the content of component (B2) is 0.5 to 20. The non-aqueous oral composition according to any one of claims 1 to 7, which is a toothpaste composition.