JP6756553B2 - Gel toothpaste - Google Patents

Description

The present invention relates to a gel-like dentifrice. More specifically, the present invention is a gel-like dentifrice based on reduced water and containing hydrolyzed eggshell membrane and Sasa kurilensis extract, which is excellent in tooth cleaning effect, periodontal disease prevention and healing effect, and halitosis prevention effect. Regarding.

Known forms of dentifrice include dentifrices, gel-like dentifrices, liquid dentifrices, and powdered dentifrices.
Of these, gel-like toothpaste has a higher water content than toothpaste, so when it is attached to a toothbrush and placed in the oral cavity, it quickly disperses to every corner of the oral cavity and promotes the toothpaste effect at an early stage. It has the advantage of doing.
Gel-like dentifrices are generally based on purified water, which is blended with abrasives, wetting agents, flavoring agents, preservatives, medicinal ingredients, etc., and further blended with a binder (thickener) to gel. (For example, Patent Document 1).
Abrasive-free gel dentifrices for children are also known, but abrasive-free gel dentifrices remove stains on the tooth surface such as plaque and stains (colored stains). Due to its low cleaning effect, gel-like dentifrices sold to the general public such as adults generally contain an abrasive.
A gel-like dentifrice with an abrasive added is superior to a gel-like dentifrice without an abrasive in a cleaning effect that removes plaque and stains adhering to the tooth surface, but on the other hand, polishing The agent easily damages the enamel on the tooth surface.

Further, dentifrices containing a hydrolyzed eggshell membrane are known (Patent Documents 2 and 3).
Toothpaste containing hydrolyzed eggshell membrane has the effect of maintaining and restoring the health of the periodontal tissue and oral mucosa, and restores the periodontal tissue itself to a strong and healthy state until then. The gums that had been suffering from periodontal disease and had a reddish purple color were turned into a healthy pink color, and the gums that had lost elasticity, tension, and luster were restored to their elasticity, tension, and luster, and bleeding from the gums. Can be eliminated. Further, even when not suffering from periodontal disease, it has an excellent effect of making the periodontal tissue less susceptible to periodontal disease and maintaining a healthy state of the periodontal tissue.
However, even with a dentifrice containing a hydrolyzed eggshell membrane, it is necessary to add an abrasive in the same way as a conventional gel-like dentifrice in order to remove stains such as plaque and stains adhering to the tooth surface. There is a risk of damaging the enamel on the tooth surface due to the formulation of the abrasive.

Further, dentifrices containing sasa extract such as bear bamboo extract are known (Patent Documents 4 and 5), and dentifrices containing sasa extract are effective in preventing and curing periodontal disease and preventing or reducing bad breath. It is said that.
However, even with a dentifrice containing Sasa extract, in order to remove plaque and stains (colored stains) adhering to the tooth surface, the above-mentioned conventional gel-like dentifrice and dentifrice containing hydrolyzed eggshell membrane are used. Similarly, it is necessary to add a dentifrice, and the addition of the dentifrice tends to damage the enamel on the tooth surface.

Japanese Unexamined Patent Publication No. 6-183937 Japanese Unexamined Patent Publication No. 2001-89393 JP-A-2007-197393 JP 2001-151655 International Publication No. 2000/67707 Japanese Patent No. 3988827 Japanese Unexamined Patent Publication No. 2001-191076 Japanese Patent No. 5253483

An object of the present invention is to maintain the health condition of the periodontal tissue and the oral mucosa of the dentifrice containing hydrolyzed eggshell membrane and to restore the health condition, and to have the periodontal disease of the dentifrice containing sasa extract. While maintaining the effects of preventing and curing diseases and preventing and reducing bad breath, it is possible to satisfactorily remove stains such as plaque and stains adhering to the tooth surface without adding toothpaste. It is to provide a gel-like dentifrice without additives that does not cause damage to tooth enamel.

In order to achieve the above object, the present inventor has made various studies. As a result, the gel-like dentifrice contains both the hydrolyzed eggshell membrane and the chishimazasa extract, and as the water forming the base material of the gel-like dentifrice, instead of the purified water conventionally widely used in the gel-like dentifrice. In addition, by using the reduced water generated in the cathode chamber of the 3-chamber water electrolyzer, plaque and stains adhering to the tooth surface can be removed extremely easily without adding a toothpaste, resulting in a cleaning effect. An excellent gel-like dentifrice can be obtained, and at the same time, the gel-like dentifrice contains the hydrolyzed eggshell membrane to maintain the health condition of the periodontal tissue and the oral mucosa and restore the health condition. It was found that it is excellent in the promotion effect of toothpaste, the prevention and cure of periodontal disease, and the prevention and reduction effect of bad breath due to the inclusion of toothpaste extract.

Further, the present inventor at that time, based on the total mass of the gel-like toothpaste, the proportion of reduced water generated in the cathode chamber of the three-chamber type water electrolyzer was 20 to 90% by mass, and the hydrolyzed eggshell membrane. It was found that it is preferable that the ratio of the above is 0.0001 to 10% by mass and the ratio of the chishimazasa extract is 0.0001 to 70% by mass.
When the present inventor further contains the foaming agent in a proportion of 0.3 to 7% by mass based on the total mass of the gel dentifrice, the gel dentifrice is satisfactorily diffused in the oral cavity. By setting the pH of the gel dentifrice to 5 to 8 to better exert the above-mentioned effects, the storage stability is excellent, the oral irritation is lessened, and the effect on the tooth enamel is affected. We have found that a small gel-like dentifrice can be obtained, and completed the present invention based on these findings.

That is, the present invention
(1) Ri name from gel product of the aqueous composition containing hydrolyzed eggshell membrane and Sasa extract in an alkaline three-chamber type electrolytic reduced water, in gel-dentifrice wherein the pH is 5 to 8 is there.
And the present invention
(2) Based on the total mass of the gel-like dentifrice, 20 to 90% by mass of the three-chamber type electrolytically reduced water, 0.0001 to 10% by mass of the hydrolyzed eggshell membrane, and 0.0001 to 70% by mass of the chishimazasa extract. Percentage of the gel-like dentifrice (1) above;
(3) The gel-like dentifrice according to (1) or (2) above, which further contains a foaming agent in a proportion of 0.3 to 7% by mass based on the total mass of the gel-like dentifrice;
(4) The gel-like dentifrice according to any one of (1) to ( 3) above, which does not contain an abrasive;
Is.

Furthermore, the present invention
(5) An anode chamber provided with an anode electrode, a cathode chamber provided with a cathode electrode, an intermediate chamber provided between the anode chamber and the cathode chamber, and a diaphragm arranged between the anode chamber and the intermediate chamber. Using a three-chamber type electrolyzed water generator with a diaphragm arranged between the cathode chamber and the intermediate chamber, water is supplied to each of the anode chamber and the cathode chamber, and an aqueous sodium chloride solution is supplied to the intermediate chamber. Reduced water is generated in the cathode chamber by electrolysis, and the reduced water generated in the cathode chamber contains hydrolyzed eggshell membrane, chishimazasa extract and gelling agent, and a pH adjuster is added to form an aqueous composition. A method for producing a gel-like toothpaste, which comprises adjusting the pH of a product to 5 to 8 to prepare an aqueous composition and gelling the aqueous composition;
(6) The method for producing a gel-like dentifrice according to ( 5 ) above, which further contains a foaming agent when preparing an aqueous composition;
Is.

Since the gel-like dentifrice of the present invention uses reduced water generated in the cathode chamber of the three-chamber type water electrolyzer as a base material instead of the purified water conventionally used in the gel-like dentifrice, it is polished. Even if it does not contain an agent, it can satisfactorily remove stains such as plaque and stains adhering to the tooth surface, has an excellent cleaning effect, and does not need to contain an abrasive. It can prevent damage to tooth enamel.
Since the gel-like dentifrice of the present invention contains a hydrolyzed eggshell membrane, it has an effect of maintaining a healthy state of the periodontium and the oral mucosa and promoting recovery to the healthy state.
Further, since the gel-like dentifrice of the present invention contains Sasa kurilensis extract, it is excellent in prevention and cure of periodontal disease and prevention and reduction of bad breath.

FIG. 1 is a diagram schematically showing the principle (basic structure) of a three-chamber type electrolyzed water generator for producing reduced water used as a base material in the gel-like dentifrice of the present invention.

The present invention will be described in detail below.
In the present invention, reduced water generated in the cathode chamber (negative electrode chamber) of the three-chamber type electrolyzed water generator is used as the water forming the base material of the gel-like dentifrice.
The three-chamber type electrolyzed water generator has been conventionally known (see, for example, Patent Documents 6 to 8), and its basic structure is an anode electrode (cathode) (1d) as shown in the schematic diagram of FIG. ), A cathode chamber (2) including a cathode electrode (negative electrode) (2d), and an intermediate chamber (3) provided between the anode chamber (1) and the cathode chamber (2). And a diaphragm (ion exchange membrane, etc.) (4) arranged between the anode chamber (1) and the intermediate chamber (3), and between the cathode chamber (2) and the intermediate chamber (3). It consists of a diaphragm (ion exchange membrane, etc.) (5).
In the three-chamber type electrolyzed water generator, the anode chamber (1) has a water inflow portion (1a) and a water (oxidized water) outflow portion (1b) generated in the anode chamber (1), and has a cathode chamber (2). ) Has an inflow part (2a) of water and an outflow part (2b) of water (reduced water) generated in the cathode chamber (2), and the intermediate chamber (3) contains an ionic compound such as an aqueous sodium chloride solution. It has a supply part (3a) for the aqueous solution contained and an outflow part (3b) for the aqueous solution.
In the production of the reduced water used for the gel-like dentifrice of the present invention, any of the conventionally known three-chamber type electrolyzed water generators can be used. Although not limited, the three-chamber electrolyzed water generator that can be used in the present invention includes, for example, a three-chamber electrolyzed water generation system manufactured by Redox Co., Ltd. and a three-chamber type double-in electrolysis manufactured by Redox Co., Ltd. System ["creski AQUA" (Type-α4000A, C, D), etc.], "Redox R25-15" manufactured by Redox Technology Co., Ltd., 3-chamber electrolyzed water generation system manufactured by Racine Co., Ltd. and 3-chamber double-in electrolysis Examples include a system and a three-chamber electrolyzed water generator manufactured by Toshiba Corporation.

In the present invention, water (particularly pure water) is supplied to each of the anode chamber and the cathode chamber of the three-chamber electrolyzed water generator as the reducing water forming the base material of the gel-like toothpaste, and the sodium chloride aqueous solution is supplied to the intermediate chamber. The reduced water generated in the cathode chamber by supplying and electrolyzing is preferably used because it has an excellent cleaning action for stains such as grime and stains adhering to the teeth and is excellent in safety.

The concentration of sodium chloride in the sodium chloride aqueous solution supplied to the intermediate chamber depends on the scale, electrolyzed water generation capacity, structure, type of model, etc. of the three-chamber electrolyzed water generator in each three-chamber electrolyzed water generator. It is preferable to use the recommended concentration.
The amount of water supplied to the anode and cathode chambers and the amount of sodium chloride aqueous solution supplied to the intermediate chamber also depend on the scale, electrolyzed water generation capacity, structure, model type, etc. of the three-chamber electrolyzed water generator. It is preferable to adopt the supply amount recommended in the three-chamber type electrolyzed water generator.

Acidic oxidation to the anode chamber by performing electrolysis using the sodium chloride concentration recommended for each model, the amount of water supplied to the anode and cathode chambers, and the amount of sodium chloride aqueous solution supplied to the intermediate chamber. Water having an action (oxidized water) is generated, and water having an alkaline reducing action (reduced water) is generated in the cathode chamber.
The pH of the reduced water generated in the cathode chamber by supplying water (particularly pure water) to each of the anode chamber and the cathode chamber of the three-chamber electrolyzed water generator and supplying an aqueous sodium chloride solution to the intermediate chamber for electrolysis. Is about 10 to 12, especially about 11 to 12.
In the present invention, in preparing an aqueous composition for gelation, a gel-like dentifrice having a high pH may be produced by using reduced water having a pH of 10 to 12 as it is without adjusting the pH, but it is excellent in storage stability. A gel dentifrice that is less irritating to the oral cavity and has a small effect on tooth enamel. Therefore, a pH adjuster is added when preparing an aqueous composition for gelation to obtain a gel dentifrice. The pH of the toothpaste is preferably 5 to 8, more preferably 5 to 7, and even more preferably 5 to 6.5.
Examples of the pH adjuster at that time include organic acids such as citric acid and sodium citrate and salts thereof, sodium hydrogen carbonate, potassium hydroxide, sodium dihydrogen phosphate, sodium monohydrogen phosphate and the like. In the gel-like toothpaste of the present invention, one or more of these can be used as needed. Of these, citric acid and sodium citrate are preferably used.

Further, in the gel-like toothpaste of the present invention, as the reduced water, the redox potential at the time of generating the reduced water by the three-chamber electrolyzed water generator is -500 mV or less, further -600 mV or less, particularly -750 mV or less. However, it is preferably used because a gel-like toothpaste having a large reducing power and an excellent cleaning effect can be obtained.
Although not limited, ultrapure water having an electric conductivity of 0.3 μS / cm (20 ° C.) is supplied to the anode chamber and the cathode chamber of the three-chamber electrolyzed water generator, and an aqueous sodium chloride solution is used as an intermediate. When the cathode chamber is subjected to electrolysis, it is possible to generate reduced water having a pH of 11.0 or more and an oxidation-reduction potential at the time of production of −600 mV or less.

The hydrolyzed eggshell membrane used in the gel-like dentifrice of the present invention is a partially hydrolyzed eggshell membrane using an acid, an alkali, a proteolytic enzyme or the like. Eggshell membranes are insoluble in water, but hydrolyzed Eggshell membranes include those that are soluble in water and those that are insoluble in water but have increased hydrophilicity compared to eggshell membranes, depending on the degree of hydrolysis. In the present invention, both a hydrolyzed eggshell membrane having a high degree of hydrolysis and a hydrolyzed eggshell membrane having a low degree of hydrolysis can be used, and among them, a water-soluble hydrolyzed eggshell membrane is preferably used. Therefore, those having a weight average molecular weight of 1,000 to 100,000, more preferably 5,000 to 50,000, and particularly those having a weight average molecular weight of 10,000 to 35,000 are preferably used.
Here, the "molecular weight of the hydrolyzed eggshell membrane" as used herein means a weight average molecular weight measured by a gel permeation chromatography (GPC) method using a high performance liquid chromatograph.

Sasa (sasa) is a plant belonging to the subfamily Gramineae, a monocotyledonous plant, and is classified into the genus Pleioblastus, Arundinaria, Sasa, Sasatake, Pseudosasa japonicum, and Pseudosasa japonicum.
Among them, Sasa kurilensis (Sasa Kurilensis) belongs to the genus Sasa along with Kumazasa and Miyakozasa, and is one of the large bamboo grasses.
The Sasa kurilensis extract used in the gel-like dentifrice of the present invention is a liquid obtained by concentrating and purifying the sap produced by high-pressure pressing of fresh leaves and stems of Sasa kurilensis.
Sasa kurilensis extract is sold in the market, and specific examples include "Sasa kurilensis extract k3-C" manufactured by Nippon Haruma Co., Ltd. and "Selpure" (registered trademark) concentrated extract of Sasa kurilensis manufactured by Sano Co., Ltd. it can.
In the gel-like dentifrice of the present invention, one or more commercially available Sasa kurilensis extracts can be used as they are as the Sasa kurilensis extract.

The gel-like toothpaste of the present invention has an effect of removing stains such as plaque and stains adhering to the tooth surface, a healing effect of wounds on periodontal tissue and oral mucosa, an oral cleaning effect, and a tooth. In order to achieve a well-balanced and effective effect of preventing and healing periodontal disease and preventing and reducing bad odor, the total mass of the gel-like toothpaste (and thus the water-based product before gelling including the binder). Based on the total mass of the composition), 20 to 90% by mass of the reduced water produced in the cathode chamber of the 3-chamber type electrolytic water generator (hereinafter, may be simply referred to as “reduced water”) and 0 of the hydrolyzed eggshell membrane. It is preferable to contain .0001 to 10% by mass and Chishimazasa extract in a proportion of 0.0001 to 70% by mass, 50 to 85% by mass of reduced water, 0.001 to 5% by mass of hydrolyzed eggshell membrane and Chishimazasa extract. Is more preferably contained in a proportion of 0.001 to 50% by mass, reduced water is 70 to 85% by mass, hydrolyzed eggshell membrane is 0.005 to 2% by mass, and plaque extract is 0.005 to 30% by mass. It is more preferably contained in a ratio of (particularly 0.005 to 5% by mass).

The gel-like dentifrice of the present invention may or may not contain a foaming agent, but the inclusion of a foaming agent promotes the diffusion of the gel-like dentifrice in the oral cavity and stains. The above-mentioned effects of the gel-like dentifrice of the present invention, including purification, can be more satisfactorily exhibited. If a foaming agent is contained, the foaming agent is added in a proportion of 0.3 to 7% by mass based on the total mass of the gel-like toothpaste (and thus the total mass of the aqueous composition before gelation containing the binder). It is preferably contained in a proportion of 0.3 to 6% by mass, more preferably 0.3 to 5% by mass, and further preferably in a proportion of 0.3 to 5% by mass.
As the effervescent agent, any of the effervescent agents conventionally used in toothpastes can be used, and specific examples thereof include lauryl glucoside, sodium lauryl sulfate, sapins strifoliatus fruit juice extract (soap nut extract), and sucrose fatty acid. Surfactants such as esters, sodium lauroyl sarcosine, and N-lauroyl-L-glutamic acid can be mentioned, and one or more of these can be used.

The gel-like dentifrice of the present invention contains hydrolyzed eggshell membrane and Sasa kurilensis extract in the reducing water generated in the cathode chamber of the three-chamber electrolyzed water generator, and in some cases contains a foaming agent, and if necessary, further other It is a gelled product of an aqueous composition containing an ingredient, and gelation of the aqueous composition is achieved by including a binder (thickener) in the aqueous composition.
The gel-like dentifrice of the present invention may contain any of the binders conventionally used in the dentifrice, and specific examples of the binder that can be used in the gel-like dentifrice of the present invention include. Cellulose derivatives such as sodium carboxymethyl cellulose (cellulose gum), methyl cellulose, hydroxyethyl cellulose and carrageenan, alginate derivatives such as sodium alginate and propylene glycol alginate, gums such as xanthan gum, gellan gum, tragant gum and carrageenan can be mentioned. One type or two or more types can be used.
The content of the binder contains reduced water, which is the water produced in the cathode chamber of the three-chamber electrolyzed water generator, hydrolyzed eggshell membrane, chishimazasa extract and, in some cases, a foaming agent, and if necessary, other components. Depending on the type of component, component composition, type of binder, etc. that make up the aqueous composition, the total mass of the gel-like toothpaste is generally adjusted so that the aqueous composition becomes a gel suitable for tooth brushing. By extension, the amount is generally preferably in the range of 0.05 to 5% by mass based on the total mass of the aqueous composition before gelation containing the binder.

Since the gel-like dentifrice of the present invention uses the above-mentioned reduced water as a base material, it can satisfactorily remove plaque, stains, etc. without containing an abrasive due to its excellent cleaning action. From the viewpoint of preventing damage to tooth enamel, it is preferable not to contain an abrasive.

The gel-like dentifrice of the present invention can contain other components conventionally used in the gel-like dentifrice in addition to the above-mentioned components, if necessary. Other ingredients that may be contained as needed include moisturizers, flavoring agents, refreshing agents, sweeteners, flavoring agents, coloring agents, emulsifiers, pH regulators, vitamins, preservatives, preservatives, medicinal ingredients and the like. be able to.

Moisturizing agents include, for example, glycerin, sorbit solution, propylene glycol, 1,3-butylene glycol, chishimazasa water, nettle extract, sardine extract, chamomile extract, white birch extract, sage extract, hop extract, melissa extract, rosemary extract and the like. Plant extracts and the like can be mentioned, and the gel-like toothpaste of the present invention can contain one or more of these.

Examples of the flavoring agent and the refreshing agent include spearmint oil, peppermint type fragrance, herb type fragrance, peppermint oil, eucalyptus oil, menthol, bergamot type fragrance, citrus mint type fragrance, fruit type fragrance, and the like. Gel-like toothpaste can contain one or more of these as needed.

Examples of the sweetener and the flavoring agent include sodium saccharin, licorice extract, xylitol (xylitol), glycyrrhizic acid, dipotassium glycyrrhizinate, stevia extract, hamamelis extract, sodium chloride, and the like, and the gel-like toothpaste of the present invention. Can contain one or more of these, if desired.

Examples of the colorant include blue No. 1, yellow No. 4, red No. 3, red No. 102, red No. 106, green No. 3, and green No. 201, and the gel-like dentifrice of the present invention is required. Depending on the above, one or more of these can be contained.

Examples of the emulsifier (solubilizer, solubilizer) include glyceryl caprylate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monooleate, sodium polyphosphate, soap base, polyoxyethylene alkyl ether phosphoric acid, and the like. Examples include polyoxyethylene hydrogenated castor oil, sodium lauryl sulfate, polyglyceryl monolaurate, sodium lauroyl sarcosin, etc., and the gel-like toothpaste of the present invention should contain one or more of these as required. Can be done.

Examples of vitamins include vitamin E, vitamin C, vitamin B12, vitamin B2, vitamin D, and the like, and the gel-like toothpaste of the present invention contains one or more of these as required. can do.

Examples of preservatives and preservatives include p-oxybenzoates such as methyl p-oxybenzoate, ethyl p-oxybenzoate, propyl p-oxybenzoate, ethylbutyl p-oxybenzoate, and ethyl ethyl p-oxybenzoate. Acid esters, alkyldiaminoethylglycine hydrochloride solution, cetylpyridinium chloride and the like can be mentioned, and the gel-like toothpaste of the present invention can contain one or more of these, if necessary.

As medicinal ingredients, for example, anti-inflammatory agents and bactericidal agents such as alkyldiaminoethylglycine hydrochloride solution, cetylpyridinium chloride, isopropylmethylphenol, triclosan, chlorhexidine gluconate, chlorhexidine, benzethonium chloride, benzalconium chloride, decanium chloride, etc. , Alkali metal monofluorophosphate (sodium monofluorophosphate, potassium monofluorophosphate, etc.), fluorides such as sodium fluoride, triclosan fluoride, etc. can be mentioned, and the gel-like toothpaste of the present invention can be mentioned. Can contain one or more of these, as needed.

The method for producing the gel-like dentifrice of the present invention is not particularly limited, and contains the hydrolyzed eggshell membrane and the chishimazasa extract, preferably further containing a foaming agent, and further blended together with these components as needed. Any method capable of producing a gel-like dentifrice in which one or more of the components are uniformly mixed in a gelled product based on reduced water generated in the cathode chamber of a three-chamber electrolyzed water generator. For example, it may be produced by any method. In general, reduced water, hydrolyzed eggshell membranes, Sasa kurilensis extract, binder and, if necessary, foaming agents and other ingredients are blended simultaneously or in any order to prepare an aqueous composition to prepare the aqueous composition. It can be produced by sufficiently stirring and mixing each component in the composition until it is uniformly mixed and gelled.

The present invention will be specifically described below with reference to examples, but the present invention is not limited to the following examples.
<< Example 1 >>
Hydrolyzed eggshell membrane (pH 11 at a temperature of 25 ° C., redox potential at the time of production = -800 mV) in 78.38 parts by mass in the cathode chamber of the "3-chamber electrolyzer" manufactured by Redox Co., Ltd. In addition to 0.01 parts by mass of Cupy) and 0.03 parts by mass of Chishimazasa extract (“Chishimazasa extract K3-C” manufactured by Nippon Haruma Co., Ltd.), the components listed in Table 1 below are added to the amounts listed in Table 1 (manufactured by Cupy). By mass), and mixed at a temperature of 25 ° C. until uniform, a gel-like toothpaste (pH = 6) using reduced water as a base material was produced.
The gel-like dentifrice thus obtained was filled in a tube-shaped container (filling amount: 100 g / tube) to produce a gel-like dentifrice in a tube.

<< Comparative Example 1 >>
In Example 1, 78.4 parts by mass of purified water was used instead of 78.38 parts by mass of reduced water, and citric acid and sodium citrate were not blended, and other than that, the same procedure as in Example 1 was carried out to add water. A gel-like toothpaste (pH = about 7) containing a decomposed eggshell membrane and citrate extract and using purified water as a base material was produced.
The gel-like dentifrice thus obtained was filled in a tube-shaped container (filling amount: 100 g / tube) to produce a gel-like dentifrice in a tube.

<< Test Example 1 >>
(1) 6 monitors A, B, C, D, E, F [Monitor A = 25 years old (female), Monitor B = 27 years old (male), Monitor C = 36 years old (female), Monitor D = 40 Year (male), monitor E = 60 years old (female), monitor F = 58 years old (male)], after lunch, brush teeth for 5 minutes using about 1.5 g of the gel-like dentifrice of Example 1. After rinsing the mouth with water 5 times, use a cotton stick impregnated with a plaque stain (GC's "Prospec stain") to apply the plaque stain to the upper and lower teeth and the gums and teeth. It was applied to the entire border and had the mouth rinsed once with water.
(2) When the same observer visually observed the inside of the mouth of each monitor and evaluated the residual state of the dental dye according to the evaluation criteria shown in Table 2 below, it is shown in Table 3 below. It was as it was.

<< Comparative Test Example 1 >>
(1) On the day following the day when Test 1 was performed, about 1.5 g of the gel-like dentifrice of Comparative Example 1 was used on the above-mentioned 6 monitors A to F after lunch in Test Example 1. Have them brush their teeth for 5 minutes in the same way as above, rinse their mouth 5 times with water, and then use a cotton swab impregnated with the same toothpaste used in Test 1 to apply the toothpaste up and down. It was applied to the teeth and the entire boundary between the gums and teeth, and the mouth was rinsed once with water.
(2) The same observer as in Test Example 1 visually observed the inside of the mouth of each monitor and evaluated the residual state of the dental dye according to the evaluation criteria shown in Table 2 below. It was as shown in Table 3 of.

From the results of Test 1 and Comparative Test 1 above, the gel-like dentifrice of Example 1 using the reduced water generated in the cathode chamber of the three-chamber electrolyzed water generator as a base material does not contain an abrasive. However, it can be seen that the effect of cleaning tooth stains such as plaque is excellent.
On the other hand, the gel-like dentifrice of Comparative Example 1 using purified water as a base material is inferior in the cleaning effect of tooth stains such as plaque, and is a conventional gel-like dentifrice for removing tooth stains. It can be seen that it is necessary to add an abrasive or the like in the same manner as above.

<< Test Example 2 >>
Performed the above on 10 monitors (ages 36-72 years, 5 men, 5 women) who feel that their gums are thin, lack elasticity and tension, have a slightly purplish reddish color, and have bad breath. Using the gel dentifrice obtained in Example 1, 3 times a day (after breakfast, after lunch and before bedtime), use about 1.5 g of the gel dentifrice once for 14 days (2 weeks) ), And the evaluation contents shown in Table 4 below were evaluated. The results were as shown in Table 4 below.

From the results in Table 4 above, the gel-like toothpaste of the present invention, which uses reduced water generated in the cathode chamber of a three-chamber type water electrolyzer as a base material and contains a hydrolyzed eggshell membrane and chishimazasa extract, is an abrasive. Even if it does not contain, it can remove stains such as plaque and stains adhering to the tooth surface well and has an excellent cleaning effect, and it also maintains the health condition of the periodontal tissue and the oral mucosa. It can be seen that it has an effect of promoting recovery from plaque, is effective in preventing and curing periodontal disease, and is also excellent in preventing and reducing bad breath.

1 Anode chamber 1a Water inflow part 1b Oxidized water outflow part 1d Anode electrode (positive electrode)
2 Cathode chamber 2a Water inflow part 2b Reduced water outflow part 2d Cathode electrode (negative electrode)
3 Intermediate chamber 3a Supply part of aqueous solution containing ionic compound (sodium chloride, etc.) 3b Outflow part of aqueous solution 4 Septum 5 Septum

Claims (6)

Gel-like dentifrice, wherein Ri name from gel product of the aqueous composition containing hydrolyzed eggshell membrane and Sasa extract in an alkaline three-chamber type electrolytic reduced water, pH is 5-8. Based on the total mass of the gel-like dentifrice, the ratio of the three-chamber type electrolytically reduced water is 20 to 90% by mass, the hydrolyzed eggshell membrane is 0.0001 to 10% by mass, and the chishimazasa extract is 0.0001 to 70% by mass. The gel-like dentifrice according to claim 1, which is contained in 1. The gel-like dentifrice according to claim 1 or 2, further containing a foaming agent in a proportion of 0.3 to 7% by mass based on the total mass of the gel-like dentifrice. The gel-like dentifrice according to any one of claims 1 to 3 , which does not contain an abrasive. An anode chamber having an anode electrode, a cathode chamber having a cathode electrode, an intermediate chamber provided between the anode chamber and the cathode chamber, a diaphragm arranged between the anode chamber and the intermediate chamber, and a cathode chamber. Using a three-chamber type electrolyzed water generator equipped with a diaphragm arranged between the intermediate chamber, water is supplied to each of the anode chamber and the cathode chamber, and an aqueous sodium chloride solution is supplied to the intermediate chamber for electrolysis. To generate reduced water in the cathode chamber, the reduced water generated in the cathode chamber contains hydrolyzed eggshell membrane, chishimazasa extract and gelling agent, and a pH adjuster is added to the pH of the aqueous composition. A method for producing a gel-like toothpaste, which comprises adjusting the above amount to 5 to 8 to prepare an aqueous composition and gelling the aqueous composition. The method for producing a gel-like dentifrice according to claim 5 , wherein a foaming agent is further contained when preparing the aqueous composition.

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