JP6800936B2 - Oral composition - Google Patents

Description

The present invention relates to an oral composition and the like, and more particularly to an oral emulsified composition and the like.

Compositions with a relatively low water content and a relatively high content of hydrocarbon oils usually have poor stability over time, and even if emulsified with an emulsifier, the hydrocarbon oils often separate after long-term storage. Is. Therefore, it was difficult to use it for each application (for example, an oral composition).

Japanese Unexamined Patent Publication No. 2014-189550 JP-A-2009-95253

An object of the present invention is to prepare an oral composition which contains a hydrocarbon oil and has good stability over time.

The present inventors have found that a composition containing a hydrocarbon oil, a polyhydric alcohol, and a surfactant may have good stability over time even though the composition contains a hydrocarbon oil, and further improvements have been made to the present invention. The invention has been completed.

The present invention includes, for example, the subjects described in the following sections.
Item 1.
An oral composition containing a hydrocarbon oil, a polyhydric alcohol, and a surfactant.
(I) Contains glycerin and polyglycerin fatty acid esters and / or alkyl glucosides
(Ii) Containing propanediol and polyoxyethylene cured castor oil and / or polyoxyethylene cured castor oil fatty acid ester,
(Iii) contains butylene glycol and polyoxyethylene alkyl ether and / or polyoxyethylene hydrogenated castor oil fatty acid ester, or (iv) polyethylene glycol and polyoxyethylene hydrogenated castor oil fatty acid ester.
Oral composition.
Item 2.
Item 2. The oral composition according to Item 1, wherein the water content is 5% by mass or less.
Item 3.
Item 2. The oral composition according to Item 1 or 2, which is a non-aqueous composition.
Item 4.
Item 8. The oral composition according to any one of Items 1 to 3, which is not phase-separated by standing at 25 ° C. for 1 week after preparation.
Item 5.
The oral composition according to any one of Items 1 to 4, wherein the hydrocarbon oil is paraffin.
Item 6.
A composition containing a hydrocarbon oil, a polyhydric alcohol, and a surfactant, which is a carrier for an oral composition.
(I) Contains glycerin and polyglycerin fatty acid esters and / or alkyl glucosides
(Ii) Containing propanediol and polyoxyethylene cured castor oil and / or polyoxyethylene cured castor oil fatty acid ester,
(Iii) contains butylene glycol and polyoxyethylene alkyl ether and / or polyoxyethylene hydrogenated castor oil fatty acid ester, or (iv) polyethylene glycol and polyoxyethylene hydrogenated castor oil fatty acid ester.
Composition.

It is possible to provide an oral composition which contains a hydrocarbon oil but has excellent stability over time. Further, it is possible to provide an oral emulsified composition which contains hydrocarbon oil and has excellent stability over time.

Hereinafter, each embodiment included in the present invention will be described in more detail. The present invention preferably includes, but is not limited to, an oral composition, a method for producing the composition, and the like, and the present invention includes all disclosed in the present specification.

The oral compositions included in the present invention contain hydrocarbon oils, polyhydric alcohols, and surfactants. The oral composition of the present invention contains (i) glycerin and polyglycerin fatty acid ester and / or alkyl glucoside, or (ii) propanediol, and polyoxyethylene hydrogenated castor oil and / or polyoxyethylene hydrogenated castor. Contains oil fatty acid esters, (iii) butylene glycol, and polyoxyethylene alkyl ethers and / or polyoxyethylene hydrogenated castor oil fatty acid esters, or (iv) polyethylene glycol, and polyoxyethylene hydrogenated castor oil. Contains fatty acid ester.

By using the combination of the polyhydric alcohols (iv) and the surfactant of (i) to (iv), it is possible to provide an oral composition which contains a hydrocarbon oil and has excellent stability over time. In (i), the polyhydric alcohol is glycerin, and the surfactants are polyglycerin fatty acid ester and alkyl glucoside. In (ii), the polyhydric alcohol is propanediol, and the surfactants are polyoxyethylene cured castor oil and polyoxyethylene cured castor oil fatty acid ester. In (iii), the polyhydric alcohol is butylene glycol, and the surfactants are polyoxyethylene alkyl ether and polyoxyethylene hydrogenated castor oil fatty acid ester. In (iv), the polyhydric alcohol is polyethylene glycol and the surfactant is a polyoxyethylene hydrogenated castor oil fatty acid ester. In addition, a polyhydric alcohol and a surfactant other than the polyhydric alcohol and the surfactant described in (i) to (iv) may be contained as long as the effect of the present invention is not impaired.

As the propanediol, either propylene glycol (1,2-propanediol) or 1,3-propanediol can be preferably used. As the butylene glycol, 1,3-butylene glycol is preferable.

Examples of the polyglycerin fatty acid ester include 8 to 24 carbon atoms (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, or 24). ) Saturated or unsaturated fatty acid and polyglycerin ester compound is preferable.

The fatty acid has more preferably 8 to 22 carbon atoms, still more preferably 10 to 20 carbon atoms, and even more preferably 10 to 18 carbon atoms. Further, the fatty acid may be a saturated fatty acid or an unsaturated fatty acid, and in the case of an unsaturated fatty acid, the number of carbon-carbon double bonds is preferably 1, 2, 3, or 4, 1 or 2. Is more preferable. Further, the fatty acid may be a linear fatty acid or a branched fatty acid. Examples of the fatty acid include capric acid, lauric acid, myristic acid, stearic acid, palmitic acid, palmitic acid, margaric acid, oleic acid, linoleic acid, bechenic acid, isocapuric acid, isolauric acid, isomiristic acid, isostearic acid, and iso. Palmitic acid, isopalmitoleic acid, isomargaric acid, isooleic acid, isolinolic acid, isobehenic acid and the like are preferably exemplified, and among them, capric acid, lauric acid, myristic acid, stearic acid, oleic acid and isostearic acid are preferable. In addition, natural fatty acids such as coconut oil fatty acid and palm oil fatty acid containing these fatty acids may be used.

Further, as the polyglycerin fatty acid ester, a mono, di, tri, tetra, penta, or cycloester compound of the fatty acid and polyglycerin is preferable, and a mono, di, or triester compound is more preferable.

The polyglycerin preferably contains an average of 4 to 12 (4, 5, 6, 7, 8, 9, 10, 11, or 12) glycerin units (-OCH ₂ CH (OH) CH _2- ). More preferably, it contains an average of 5-10 glycerin units.

Specific preferred polyglycerin fatty acid esters include, for example, polyglyceryl caprate-n ¹ , polyglyceryl laurate-n ¹ , polyglyceryl myristate-n ¹ , polyglyceryl stearate-n ¹ , polyglyceryl oleate-n ¹ , di. polyglyceryl myristate -n ^1, polyglyceryl distearate -n ^1, polyglyceryl diisostearate -n ^1, trilaurate polyglyceryl -n ^1, trimyristate polyglyceryl -n ^{1 (n 1} here represents the number of glycerol units, As described above, it is preferably 4 to 12, particularly preferably 5 or 10) and the like. The polyglycerin fatty acid ester can be used alone or in combination of two or more.

The alkyl glycoside is a compound having a structure in which a higher alcohol and a sugar are glycosidic bonded.

As the higher alcohol, for example, an alkyl alcohol having 6 to 18 carbon atoms (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17 or 18) is preferable, and an alkyl alcohol having 8 to 18 carbon atoms is preferable. 16 alkyl alcohols are more preferred. The alkyl alcohol may be linear or branched chain, and is preferably linear. Further, the number of OH groups contained in the alkyl alcohol is preferably 1.

The sugar (sugar that glycosidic bonds with a higher alcohol) may be a monosaccharide or a polysaccharide, and in the case of a polysaccharide, for example, 2 to 6 (2, 3, 4, 5, or 6) sugar is preferable, and among them, 2 or 3 sugars are preferred. As the monosaccharide, for example, glucose, maltose and the like are preferable, and glucose is particularly preferable. Further, as the polysaccharide, for example, one in which at least one selected from the group consisting of glucose and maltose is bound by a plurality of glycosidic bonds is preferable, and one in which glucose is glycosidic bonded is particularly preferable. The glycosidic bond can be an α or β glycosidic bond. Alkyl glucosides can be used alone or in combination of two or more.

As the polyoxyethylene cured castor oil, POE (n ³ ) cured castor oil (where n ³ represents the average number of moles of EO added, preferably about 10 to 150, more preferably about 15 to 130, 20 to 20 About 120 is more preferable). This can also be described as PEG-n ³ hydrogenated castor oil. The polyoxyethylene cured castor oil can be used alone or in combination of two or more.

As the polyoxyethylene cured castor oil fatty acid ester, POE (n ⁴ ) cured castor oil (where n ⁴ represents the average number of moles of EO added, preferably about 3 to 70, more preferably about 4 to 60, and more preferably about 4 to 60. 5 to 50 are more preferred. Note that this is to be able to be described as ^{PEG-n 4} hydrogenated castor oil.), for example, a carbon number 8 to 24 (8,9,10,11,12,13 , 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, or 24) ester compounds with saturated or unsaturated fatty acids are preferred. The fatty acid has more preferably 8 to 22 carbon atoms, still more preferably 10 to 20 carbon atoms, and even more preferably 12 to 18 carbon atoms. Further, the fatty acid may be a saturated fatty acid or an unsaturated fatty acid, and in the case of an unsaturated fatty acid, the number of carbon-carbon double bonds is preferably 1, 2, 3, or 4, 1 or 2. Is more preferable. Further, the fatty acid may be a linear fatty acid or a branched fatty acid. Examples of the fatty acid include capric acid, lauric acid, myristic acid, stearic acid, palmitic acid, palmitic acid, margaric acid, oleic acid, linoleic acid, bechenic acid, isocapuric acid, isolauric acid, isomiristic acid, isostearic acid, and iso. Palmitic acid, isopalmitoleic acid, isomargaric acid, isooleic acid, isolinolic acid, isobehenic acid and the like are preferably exemplified, and among them, capric acid, lauric acid, myristic acid, stearic acid, oleic acid and isostearic acid are preferable. In addition, natural fatty acids such as coconut oil fatty acid and palm oil fatty acid containing these fatty acids may be used.

The polyoxyethylene hydrogenated castor oil fatty acid ester is preferably a mono, di, tri, tetra, penta, or cycloester compound of the fatty acid and POE (n ⁴ ) cured castor oil, and is preferably mono, di, or cycloester. Triester compounds are more preferred.

Preferred polyoxyethylene cured castor oil fatty acid esters include, for example, polyoxyethylene laurate (n ⁴ ) cured castor oil, polyoxyethylene isostearate (n ⁴ ) cured castor oil, and polyoxyethylene triisostearate. (N ⁴ ) Hardened castor oil (n ⁴ here represents the average number of moles of EO added, and as described above, it is preferably about 3 to 70, more preferably about 4 to 60, and even more preferably about 5 to 50. ) Etc. can be mentioned. The polyoxyethylene hydrogenated castor oil fatty acid ester can be used alone or in combination of two or more.

As the polyoxyethylene alkyl ether, the alkyl group has 8 to 24 carbon atoms (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, Or 24) is preferable. It is more preferably 8 to 22, still more preferably 10 to 20, and even more preferably 12 to 18. Further, the alkyl group can be linear or branched chain, and more preferably linear.

The average number of moles of ethylene oxide unit (EO) added is preferably about 2 to 100, more preferably about 2 to 50, and even more preferably about 2 to 40.

Specific preferred polyoxyethylene alkyl ethers include, for example, POE (n ⁵ ) lauryl ether, POE (n ⁵ ) cetyl ether, POE (n ⁵ ) stearyl ether, POE (n ⁵ ) behenyl ether, POE (n ⁵ ). ⁵ ) Oleyl ether (n ⁵ here represents the average number of moles of EO added, and as described above, it is preferably about 2 to 100, more preferably about 2 to 50, and about 2 to 40. It is more preferable to have) and the like. Further, the polyoxyethylene alkyl ether can be used alone or in combination of two or more.

Further, the surfactant that can be used other than the surfactants described in (i) to (iv) is not particularly limited as long as the effect of the present invention is not impaired, but a nonionic surfactant is preferable, and more specifically. For example, polyethylene glycol fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene fatty acid glyceryl, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene sterol and the like can be mentioned.

Further, the HLB (Hydrophyllic-Lipopicular Balance) of the surfactant used, including the surfactants described in (i) to (iv), is not particularly limited as long as the effect of the present invention is not impaired. For example, about 7 to 18 is preferable. The upper or lower limit of the range is, for example, 7.5, 8, 8.5, 9, 9.5, 10, 10.5, 11, 11.5, 12, 12.5, 13, 13.5, 14 , 14.5, 15, 15.5, 16, 16.5, 17, or 17.5.

Examples of the polyethylene glycol fatty acid ester include 8 to 24 carbon atoms (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, or 24). ) Saturated or unsaturated fatty acid and polyethylene glycol ether, an ester compound is preferable.

The fatty acid has more preferably 8 to 22 carbon atoms, still more preferably 10 to 20 carbon atoms, and even more preferably 12 to 18 carbon atoms. Further, the fatty acid may be a saturated fatty acid or an unsaturated fatty acid, and in the case of an unsaturated fatty acid, the number of carbon-carbon double bonds is preferably 1, 2, 3, or 4, 1 or 2. Is more preferable. Further, the fatty acid may be a linear fatty acid or a branched fatty acid. Examples of the fatty acid include capric acid, lauric acid, myristic acid, stearic acid, palmitic acid, palmitic acid, margaric acid, oleic acid, linoleic acid, bechenic acid, isocapuric acid, isolauric acid, isomiristic acid, isostearic acid, and iso. Palmitic acid, isopalmitoleic acid, isomargaric acid, isooleic acid, isolinolic acid, isobehenic acid and the like are preferably exemplified, and among them, capric acid, lauric acid, myristic acid, stearic acid, oleic acid and isostearic acid are preferable. In addition, natural fatty acids such as coconut oil fatty acid and palm oil fatty acid containing these fatty acids may be used.

Further, the polyethylene glycol has an average number of moles of ethylene oxide units (EO) added of preferably about 2 to 150, more preferably about 10 to 140, and even more preferably about 20 to 130.

Further, as the polyethylene glycol fatty acid ester, a mono, di, tri, tetra, penta, or cycloester compound of the fatty acid and polyethylene glycol is preferable, and a mono or diester compound is more preferable.

Specific preferred polyethylene glycol fatty acid esters include, for example, polyethylene glycol monolaurate-n ⁶ , polyethylene glycol monostearate-n ⁶ , polyethylene glycol monooleate-n ⁶ , monoisostearic polyethylene glycol-n ⁶ , and dilaurin. acid polyethylene glycol -n ^6, polyethylene glycol -n ⁶ distearate, dioleate polyethylene glycol -n ^{6, n 6} polyethylene glycol -n ⁶ diisostearate (here represents the average added mole number of EO, as described above It is preferably about 2 to 150, more preferably about 10 to 140, and even more preferably about 20 to 130).

Examples of the polyoxyethylene sorbitan fatty acid ester include 8 to 24 carbon atoms (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, Alternatively, an ester compound of the saturated or unsaturated fatty acid of 24) and the polyethylene glycol ether of sorbitol is preferable.

The fatty acid has more preferably 8 to 22 carbon atoms, still more preferably 10 to 20 carbon atoms, and even more preferably 12 to 18 carbon atoms. Further, the fatty acid may be a saturated fatty acid or an unsaturated fatty acid, and in the case of an unsaturated fatty acid, the number of carbon-carbon double bonds is preferably 1, 2, 3, or 4, 1 or 2. Is more preferable. Further, the fatty acid may be a linear fatty acid or a branched fatty acid. Examples of the fatty acid include capric acid, lauric acid, myristic acid, stearic acid, palmitic acid, palmitic acid, margaric acid, oleic acid, linoleic acid, bechenic acid, isocapuric acid, isolauric acid, isomiristic acid, isostearic acid, and iso. Palmitic acid, isopalmitoleic acid, isomargaric acid, isooleic acid, isolinolic acid, isobehenic acid and the like are preferably exemplified, and among them, capric acid, lauric acid, myristic acid, stearic acid, oleic acid and isostearic acid are preferable. In addition, natural fatty acids such as coconut oil fatty acid and palm oil fatty acid containing these fatty acids may be used.

Further, in the polyoxyethylene, the average number of moles of ethylene oxide units (EO) added is preferably about 20 to 80, more preferably about 25 to 70, and even more preferably about 30 to 60. ..

Further, as the polyoxyethylene sorbitan fatty acid ester, a mono, di, tri, tetra, penta, or cycloester compound of the fatty acid and polyethylene glycol ether of sorbitol is preferable, and a tri or tetra ester compound is more preferable.

Preferred polyoxyethylene sorbitan fatty acid esters, it specifically, for example, tetraoleate sorbeth -n 7 ^{(n 7} here represents the average added mole number of EO, is as 20 to 80 of the It is preferably about 25 to 70, more preferably about 30 to 60) and the like.

Polyoxyethylene fatty acid glyceryl is a polyethylene glycol ether of fatty acid glyceryl (monoester of fatty acid and glycerin), for example, having 8 to 24 carbon atoms (8, 9, 10, 11, 12, 13, 14, 15, 16). , 17, 18, 19, 20, 21, 22, 23, or 24), preferably a monoester of saturated or unsaturated fatty acid and glycerin with polyethylene glycol bonded (ether bond).

The fatty acid has more preferably 8 to 22 carbon atoms, still more preferably 10 to 20 carbon atoms, and even more preferably 12 to 18 carbon atoms. Further, the fatty acid may be a saturated fatty acid or an unsaturated fatty acid, and in the case of an unsaturated fatty acid, the number of carbon-carbon double bonds is preferably 1, 2, 3, or 4, 1 or 2. Is more preferable. Further, the fatty acid may be a linear fatty acid or a branched fatty acid. Examples of the fatty acid include capric acid, lauric acid, myristic acid, stearic acid, palmitic acid, palmitic acid, margaric acid, oleic acid, linoleic acid, bechenic acid, isocapuric acid, isolauric acid, isomiristic acid, isostearic acid, and iso. Palmitic acid, isopalmitoleic acid, isomargaric acid, isooleic acid, isolinolic acid, isobehenic acid and the like are preferably exemplified, and among them, capric acid, lauric acid, myristic acid, stearic acid, oleic acid and isostearic acid are preferable. In addition, natural fatty acids such as coconut oil fatty acid and palm oil fatty acid containing these fatty acids may be used.

Further, the polyoxyethylene has an average number of moles of ethylene oxide units (EO) added of preferably about 3 to 200, more preferably about 5 to 50, and even more preferably about 5 to 30. ..

Further, as the polyoxyethylene fatty acid glyceryl, it is preferable that only one of the two hydroxyl groups of the fatty acid glyceryl is ether-bonded to polyethylene glycol.

Preferred polyoxyethylene fatty acid glyceryl, specifically, for example, n ⁸ stearic acid PEG-n ⁸ glyceryl (here represents the average added mole number of EO, is said is about 3 to 200 as It is preferably about 5 to 50, more preferably about 5 to 30) and the like.

As a polyoxyethylene polyoxypropylene alkyl ether, the alkyl group has 8 to 24 carbon atoms (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22). , 23, or 24) is preferable. It is more preferably 8 to 22, still more preferably 10 to 20, and even more preferably 12 to 18. Further, the alkyl group may be linear or branched chain.

The average number of moles of ethylene oxide unit (EO) added is preferably about 2 to 100, more preferably about 2 to 50, and even more preferably about 2 to 40. The average number of moles of propylene oxide unit (PO) added is preferably about 2 to 12, more preferably about 2 to 10, and even more preferably about 4 to 8.

Specific examples of the preferred polyoxyethylene polyoxypropylene alkyl ether include, for example, PPG-y ceteth-x and PPG-y decyltetradeceth-x (where x represents the average number of moles of EO added. As described above, it is preferably about 2 to 100, more preferably about 2 to 50, still more preferably about 2 to 40, and y here represents the average number of moles of PO added. As described above, it is preferably about 2 to 12, more preferably about 2 to 10, and even more preferably about 4 to 8).

As the polyoxyethylene sterol, PEG-n ⁹ phytosterol (where n ⁹ represents the average number of moles of EO added, is preferably about 5 to 100, more preferably about 5 to 50, still more preferably about 10 to 40. ) Is preferable.

Examples of the hydrocarbon oil include paraffin, squalane, microcrystalline wax, petrolatum, ceresin, limonene, turpentine and the like. In particular, known hydrocarbon oils used in oral compositions are preferable, and squalane and paraffin are particularly preferable. Paraffin is preferred. As the squalane, both animal squalane and plant squalane can be used, and for example, shark squalane, olive squalane and the like can be preferably used. Further, as the paraffin, liquid paraffin is preferable, and light liquid paraffin is more preferable. The hydrocarbon oil may be used alone or in combination of two or more.

The content ratio of the hydrocarbon oil and the surfactant in the oral composition of the present invention is, for example, preferably about 2 to 125 parts by mass with respect to 1 part by mass of the surfactant, and 3 to 110 parts by mass. About 5 to 100 parts by mass is more preferable, and about 5 to 100 parts by mass is further preferable.

The content ratio of the polyhydric alcohol and the surfactant in the oral composition of the present invention is, for example, preferably about 3 to 75 parts by mass, and 7 to 75 parts by mass with respect to 1 part by mass of the surfactant. About 60 parts by mass is more preferable, and about 8 to 50 parts by mass is further preferable.

The content ratio of the hydrocarbon oil and the polyhydric alcohol in the oral composition of the present invention is preferably, for example, about 0.10 to 10 parts by mass of the hydrocarbon oil with respect to 1 part by mass of the polyhydric alcohol. About 0.13 to 8 parts by mass is more preferable, and about 0.15 to 5 parts by mass is further preferable.

The content ratio of the hydrocarbon oil and the surfactant, the content ratio of the polyhydric alcohol and the surfactant, and the content ratio of the hydrocarbon oil and the polyhydric alcohol in the oral composition of the present invention are prepared by the oral composition. If this is the case, it is not particularly limited, but it is preferable to satisfy any one, more preferably any two, and even more preferably all three.

The contents of the hydrocarbon oil, the polyhydric alcohol, and the surfactant in the oral composition of the present invention are not particularly limited as long as the oral composition of the present invention is prepared, but the hydrocarbon oil is not particularly limited. The hydrocarbon oil is preferably about 3 to 85% by mass, more preferably about 5 to 80% by mass, still more preferably about 15 to 75% by mass, based on the total mass of the polyhydric alcohol and the surfactant. The polyhydric alcohol is preferably about 7 to 95% by mass, more preferably about 15 to 90% by mass, and about 20 to 80% by mass with respect to the total mass of the hydrocarbon oil, the polyhydric alcohol and the surfactant. Is even more preferable. The surfactant is preferably about 0.3 to 7% by mass, more preferably about 0.5 to 6% by mass, and 1 to 1 to the total mass of the hydrocarbon oil, the polyhydric alcohol, and the surfactant. About 5% by mass is more preferable.

In addition, these content ratios and contents are values calculated based on the total of all polyhydric alcohols contained in the oral composition of the present invention and the total of all surfactants. For example, when a polyhydric alcohol and a surfactant other than the polyhydric alcohol and the surfactant described in (i) to (iv) are contained, the content of the other polyhydric alcohol and the surfactant is (i). i) Calculated after adding up the contents of the polyhydric alcohol and the surfactant described in (iv).

The oral composition of the present invention may contain water as long as the effects of the present invention are not impaired. Specifically, for example, the water content is preferably 5% by mass or less. Further, the upper limit of the water content range may be 4, 3, 2, 1, or 0.5% by mass. The oral composition of the present invention is more preferably a water-free composition (that is, a non-aqueous composition). However, when the composition contains an amount of water that is difficult to remove as an unavoidable impurity, it is included in the "non-aqueous composition" here.

The oral composition of the present invention is preferably an emulsified composition. In addition, the oral composition of the present invention is a hydrocarbon oil particularly when it is allowed to stand at room temperature (25 ° C.) for 1 week after preparation, more preferably when it is allowed to stand at room temperature (25 ° C.) for 1 month after preparation. Is preferable that does not separate (does not cause phase separation). The form of the oral composition of the present invention is not particularly limited, but is preferably gel-like or cream-like, for example.

As a method for preparing the oral composition of the present invention, for example, a polyhydric alcohol and a surfactant are first stirred and mixed, and then a hydrocarbon oil is gradually added to the mixture and mixed while continuing stirring. Can be mentioned. Mixing can be performed by a known stirrer (for example, a disper mixer or the like). If a large amount of hydrocarbon oil is added at one time, it may not be mixed uniformly, so it is preferable to add it little by little.

The oral composition of the present invention is not particularly limited, but according to a conventional method, for example, a dentifrice (for example, a dentifrice), a liquid dentifrice, a mouthwash (mouthwash), a gel, an ointment-like preparation, etc. It can be in the usual dosage form such as pasta and gum.

The oral composition of the present invention may contain known components that can be contained in the oral composition as long as the effects of the present invention are not impaired. The oral composition of the present invention to which such a component is added can be prepared, for example, by a method in which the polyhydric alcohol and the surfactant are first stirred and mixed, and the components are added and mixed together. ..

Such known components include, for example, abrasives, wetting agents, foaming agents, fragrances, activators, sweeteners, preservatives, colorants, pH regulators, stabilizers, flavoring agents, astringents, thickeners. Examples include agents and other medicinal agents. It should be noted that such known components can be used alone or in combination of two or more.

As an abrasive, calcium dibasic phosphate, dihydrate and anhydride, calcium phosphate, calcium phosphate tribasic, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, silicic anhydride, silica gel, aluminum silicate, calcium silicate, Insoluble sodium metaphosphate, magnesium tertiary phosphate, magnesium carbonate, calcium sulfate, polymethylmethacrylate, bentonite, zirconium silicate, hydroxyapatite, synthetic resin, bioactive glass and the like can be used.

Examples of the wetting agent include alcohols (monohydric alcohols or polyhydric alcohols), and more specifically, ethanol. Further, as the polyhydric alcohol, a divalent or trivalent alcohol is preferably exemplified. The divalent alcohol and the trihydric alcohol are not particularly limited, and examples thereof include ethylene glycol, propanediol, diethylene glycol, polyethylene glycol, 1,3-butylene glycol, and glycerin. As the propanediol, either propylene glycol (1,2-propanediol) or 1,3-propanediol can be preferably used. Of these, propylene glycol, 1,3-propanediol, 1,3-butylene glycol, and glycerin are preferable, and propylene glycol and glycerin are particularly preferable.

Examples of the effervescent agent include higher alkyl sulfates having 8 to 18 carbon atoms in alkyl groups such as sodium lauryl sulfate and sodium myristyl sulfate; N-long-chain acyl amino acid salts, α-olefin sulfonate salts, and sodium higher fatty acids. Monoglyceride Monosulfate, N-Methyl-N-Palmityrulide Salt, N-Acylsulfosin Sodium, N-Acyl Glutamate, N-Methyl-N-Acyl Taurine Sodium, N-Methyl-N-Acylalanine Sodium, α-Olefin Examples thereof include anionic surfactants such as sodium sulfonate.

Fragrances include, for example, menthol, anetol, carboxylic, eugenol, limonene, peppermint oil, spearmint oil, winter green, methyl salicylate, sionale, timol, chopstick oil, eucalyptus oil, rosemary oil, sage oil, lemon oil, orange oil. , Osimen oil, citronellol, methyleugenol and the like.

Sweeteners include, for example, sodium saccharin, acesulfarm potassium, stebioside, neohesperidyldihydrochalcone, glycyrrhizin, perillartine, taumatin, aspalathylphenylalanylmethyl ester, α-methoxycinnamic aldehyde, xylit, sucralose, palatinose, stevia. Examples include fins.

Examples of the preservative include parabens such as methylparaben, ethylparaben, propylparaben and butylparaben, sodium benzoate, phenoxyethanol, alkyldiaminoethylglycine hydrochloride and the like.

Examples of the colorant include legal pigments such as Blue No. 1, Yellow No. 4, Red No. 202, and Green No. 3, mineral pigments such as ultramarine, enhanced ultramarine, and navy blue, and titanium oxide.

Examples of the pH adjuster include citric acid, phosphoric acid, malic acid, pyrophosphate, lactic acid, tartaric acid, phytic acid, glycerophosphate, acetic acid, nitric acid, or chemically possible salts thereof and sodium hydroxide. Be done.

Examples of the stabilizer include sodium edetate, sodium thiosulfate, sodium sulfite, sodium chloride, calcium lactate, lanolin, triacetin, castor oil, magnesium sulfate and the like.

Examples of the flavoring agent include tea extract, tea tar, propolis extract, monosodium glutamate and the like.

Examples of the astringent include baking soda, aluminum lactate, a zinc compound and the like.

Examples of the thickener include cellulose derivatives such as hydroxyethyl cellulose, carboxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose and hydroxymethyl ethyl cellulose, gums such as xanthan gum, locust bin gum, carrageenan, tragacanto gum, karaya gum, Arabic gum and gellan gum. Synthetic binders such as polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, inorganic binders such as thickening silica, aluminum silica gel, bee gum, sodium alginate, pectin, agar, gelatin, soybean polysaccharides, chondroitin Examples thereof include sodium sulfate and sodium hyaluronate.

Other medicinal agents include fluorine compounds such as sodium fluoride, sodium monofluorophosphate and stannous fluoride; potassium salts such as potassium nitrate and potassium chloride, strontium salts such as strontium chloride, dextranase, mutanase and amylase. , Proteas, lytic enzymes (Litec Enzyme) and other enzymes; tranexamic acid, ε-aminocaproic acid, aluminum chlorohydroxyalantin, allantin, dihydrocholesterol, glycyrrhizinic acids, glycyrrhetinic acid, bisabolol, isopropylmethylphenol, glycerophosphate, chlorophyll, gluconic acid. Copper, sodium chloride, water-soluble inorganic phosphoric acid compound, pyrrolidone carboxylic acid, chlorhexidine salts, triclosan, cetylpyridinium chloride, benzalconium chloride, benzethonium chloride; acetic acid-dl-α-tocopherol, pyridoxin acetate, ascorbic acid or salts thereof, etc. Vitamins; basic amino acids such as arginine, lysine, citrulin, ornithine, creatine, histidine, diaminobutanoic acid, diaminopropionic acid or salts thereof; polyphenols such as flavonoids and phenolic acids; aloe, ginkgo biloba, agarix, oolong tea, Kamitsure, Karin, Gymnema, Kumazasa, Jincha, Tochucha, Dokudami, Hatomugi, Megusurinoki, Yomogi, Green Tea, Louis Boss, Lemon Balm, Rosemary, Clubmin, Lacanca, Perilla, Cranberry, Nokogirisou, Elder, Ricoli, Hakka, Eucalyptus , Kanzo, Bodaiju, Hope, Cacao, Kwa leaf, Thyme, Plant extracts such as Ogon, Lactobacillus, Hydrogen peroxide and the like.

The blending amount of these known components can be appropriately adjusted with reference to the amount blended in a normal oral composition as long as the effects of the present invention are not impaired.

The present invention also includes carriers for oral compositions containing hydrocarbon oils, polyhydric alcohols, and polyglycerin fatty acid esters and / or alkyl glucosides. The structure of the oral composition carrier is basically the same as that of the oral composition, except that the use is the carrier for the oral composition.

A suitable oral composition can be produced by further adding a component permitted for the oral composition (for example, the above-mentioned known component) to the carrier for the oral composition.

In addition, in this specification, "including" also includes "consisting essentially" and "consisting of" (The term "comprising" includes "consisting essentially of" and "consisting of."). The present invention also includes all combinations of the constituent elements described herein.

In addition, the various properties (property, structure, function, etc.) described for each embodiment of the present invention described above may be combined in any way in specifying the subject matter included in the present invention. That is, the present invention includes all subjects consisting of any combination of each combinable property described herein.

Hereinafter, the present invention will be described in more detail, but the present invention is not limited to the following examples. Hereinafter, unless otherwise specified, "%" indicates "mass%". In addition, the blending amount value of each component described in each table also indicates "mass%" unless otherwise specified. Further, among the raw materials listed in each table, those in which the wording indicating the number of fatty acid bonds (for example, di, bird, etc.) is not described represents “thing”. (For example, polyglyceryl-10 laurate means polyglyceryl-10 monolaurate.) POE represents polyoxyethylene, and PEG represents polyethylene glycol.

Preparation of oral composition 1
According to the compositions shown in Tables 1 and 2 (numerical values indicate mass%), polyglyceryl laurate-10 was added in addition to glycerin and light liquid paraffin to prepare an oral composition. Mixing was performed in more detail as follows. Glycerin and polyglyceryl laurate-10 were added to a container (beaker), and these were mixed by manual stirring using a glass rod or stirring with a disper mixer. At this time, heating was performed as necessary. Light liquid paraffin was added little by little while stirring was continued. The light liquid paraffin used was Moresco White P-70 (MORESCO Co., Ltd.).

Immediately after the preparation, each composition obtained was visually observed to confirm the presence or absence of phase separation. Those in which phase separation did not occur and remained in a gel state (emulsified state) were evaluated as ◯, and those in which the oil phase was separated were evaluated as × (evaluation of availability). Further, the obtained composition was filled in a glass container, allowed to stand at room temperature (25 ° C.) for 1 week, and then visually observed again and evaluated in the same manner (stability evaluation for 1 week). Unless otherwise specified, those having a stability evaluation of ◯ for 1 week were stable without phase separation until about 1 month at room temperature. The results are also shown in Tables 1 and 2.

It was found that the compositions shown in the examples did not undergo phase separation and remained stably emulsified even after 1 week.

Preparation of oral composition 2
According to the composition shown in Table 3 (numerical value indicates mass%), various surfactants were added in addition to glycerin and light liquid paraffin to prepare an oral composition, and the stability was evaluated in the same manner as above. .. Only in Example 3-5, Moresco White P-350 (MORESCO Co., Ltd.) was used as the light liquid paraffin. Moresco White P-70 is a light liquid paraffin with a kinematic viscosity of 12.56 mm ² / s (40 ° C) and an average molecular weight of 323, whereas Moresco White P-350 has a kinematic viscosity of 67.65 mm. It is a light liquid paraffin having an average molecular weight of 483 at ² / s (40 ° C.). The results are also shown in Table 3. In addition, ◯ ₍₁₎ in Table 3 shows that it was stable for 1 week after standing, but separated in about 1 month.

It was found that the compositions shown in the examples did not undergo phase separation and remained stably emulsified even after 1 week.

Preparation of oral composition 3
According to the compositions shown in Tables 4 to 6 (numerical values indicate mass%), various surfactants were added in addition to glycerin and light liquid paraffin to prepare an oral composition, and stability was obtained in the same manner as above. Was evaluated. The alkyl glycoside used in Tables 5 and 6 is Plantarea 1200UP (BASF), and more specifically, it is an aqueous solution of a polyglycoside of an alkyl alcohol having 12 to 16 carbon atoms. The water content is about 47-50%. The results are shown in Tables 4 to 6.

It was found that the compositions shown in the examples did not undergo phase separation and remained stably emulsified even after 1 week.

Preparation of oral composition 4
According to the compositions shown in Tables 7 to 9 (numerical values indicate mass%), various surfactants were added in addition to various polyhydric alcohols and light liquid paraffins to prepare oral compositions, and the same procedure as described above was performed. Stability was evaluated. The results are also shown in Tables 7-9.

It was found that the compositions shown in the examples did not undergo phase separation and remained stably emulsified even after 1 week.

An example of prescribing the oral composition of the present invention is shown below. The blending amount (%) of each formulation example indicates mass%. The composition of glycerin: polyglyceryl laurate-10: light liquid paraffin = 35: 5: 60 was used as a base. The following formulation was stable with no oil separation even after standing at room temperature for 1 week.

Claims (4)

Hydrocarbon oils, polyhydric alcohols, and containing a surfactant, a Der Ru oral composition content of 5 wt% water,
(I) Contains glycerin and polyglycerin fatty acid ester and / or alkyl glucoside (however, does not contain polyethylene glycol having an average molecular weight of more than 2000 and not more than 20000) .
(Ii) Containing propanediol and polyoxyethylene cured castor oil and / or polyoxyethylene cured castor oil fatty acid ester,
(Iii) contains butylene glycol and polyoxyethylene alkyl ether and / or polyoxyethylene hydrogenated castor oil fatty acid ester, or (iv) liquid polyethylene glycol and polyoxyethylene hydrogenated castor oil fatty acid ester.
Oral composition. A non-aqueous composition, the oral composition of claim 1. The oral composition according to claim 1 or 2 , which is not phase-separated by standing at 25 ° C. for 1 week after preparation. The oral composition according to any one of claims 1 to 3 , wherein the hydrocarbon oil is paraffin.