JP7570166B2 - Oral Composition - Google Patents

Description

The present invention relates to an oral composition that has excellent fragrance and fragrance persistence of oil-soluble flavorings.

In oral compositions such as mouth fresheners, mouthwashes, and liquid dentifrices, oil-soluble flavorings are blended to provide a pleasant fragrance during use. Various formulation techniques have been investigated to improve the fragrance of oil-soluble flavorings in oral compositions. For example, Patent Document 1 discloses a liquid oral composition that contains (A) 0.01 to 0.5% by mass of myristoyl glutamate, (B) at least one or more nonionic surfactants selected from polyoxyethylene hydrogenated castor oil, glycerin fatty acid esters, and sugar fatty acid esters, (C) an oil-soluble flavoring, and (D) 90% by mass or more of water, and in which the mass ratio of component (B) to component (A) ((B)/(A)) is 5 to 50, as an oral composition that provides a sufficient fragrance derived from the oil-soluble flavoring.

In recent years, the demands for oral compositions have become more diverse, and there is a demand for oral compositions that have a strong and long-lasting fragrance. Increasing the amount of oil-soluble flavoring makes the fragrance stronger, but oil-soluble flavorings have their own bitterness and irritating properties, and increasing the amount of oil-soluble flavoring reduces the feeling of use.

Thus, there is a demand for oral compositions that have a strong and long-lasting fragrance, but conventional formulations are no longer able to meet this demand.

JP 2013-181011 A

The object of the present invention is to provide an oral composition that has excellent fragrance and fragrance persistence of oil-soluble flavorings.

The inventors conducted extensive research to solve the above problems and discovered that by incorporating a polar oil together with an oil-soluble flavoring in an oral composition, the fragrance can be dramatically improved without increasing the amount of oil-soluble flavoring, and the fragrance durability can also be improved. The present invention was completed based on this knowledge and through further research.

That is, the present invention provides the following aspects.
Item 1. An oral composition comprising an oil-soluble flavoring and a polar oil.
Item 2. The oral composition according to Item 1, wherein the polar oil is a fatty acid ester and/or a vegetable oil.
Item 3. The oral composition according to Item 2, wherein the polar oil is at least one selected from the group consisting of a monoester in which one fatty acid molecule is bonded to one molecule of a monohydric or polyhydric alcohol, a diester in which two fatty acid molecules are bonded to one molecule of a polyhydric alcohol, a triester in which three fatty acid molecules are bonded to one molecule of a trihydric or higher polyhydric alcohol, and a tetraester in which four fatty acid molecules are bonded to one molecule of a tetrahydric or higher polyhydric alcohol.
Item 4. The oral composition according to any one of Items 1 to 3, wherein the polar oil is at least one selected from the group consisting of isopropyl myristate, propylene glycol dicaprylate, triethylhexanoin, diglyceryl triisostearate, and pentaerythritol tetraethylhexanoate.
Item 5. The oral composition according to any one of Items 1 to 4, comprising 0.01% by weight or more of the polar oil.
Item 6. The oral composition according to any one of Items 1 to 5, further comprising a monohydric lower alcohol.
Item 7. The oral composition according to any one of Items 1 to 6, further comprising a polyhydric alcohol.
Item 8. A method for improving the fragrance and persistence of an oil-soluble flavor in an oral composition containing an oil-soluble flavor, comprising:
A method of incorporating an oil soluble flavor and a polar oil into an oral composition.

According to the present invention, by using a polar oil together with an oil-soluble flavoring in an oral composition, it is possible to enhance the aroma of the oil-soluble flavoring (the intensity of the aroma felt when applied to the oral cavity) without increasing the amount of oil-soluble flavoring, and also improve the persistence of the aroma, thereby providing an oral composition with improved usability.

1. Oral Composition The oral composition of the present invention is characterized by containing an oil-soluble flavoring and a polar oil. In the oral composition of the present invention, the oil-soluble flavoring and polar oil are contained, so that the aroma of the soluble flavoring and the persistence of the aroma can be improved. The oral composition of the present invention will be described in detail below.

[Oil-soluble fragrance]
The oral composition of the present invention contains an oil-soluble flavoring. The type of the oil-soluble flavoring used in the present invention is not particularly limited, as long as it is applicable to the oral cavity, and examples thereof include single flavorings and essential oils.

Specific examples of single fragrances include menthol, carvone, anethole, eugenol, cineole, thymol, geraniol, citronellol, vanillin, methyl salicylate, menthone, isomenthone, limonene, pinene, pulegone, menthyl lactate, terpinyl acetate, terpineol, linalool, benzyl succinate, methyl eugenol, ocimene, methyl acetate, citronenyl acetate, ethyl linalool, vanillin, etc. These single fragrances may be synthetic or may be purified from natural sources.

Specific examples of essential oils include mint oils such as spearmint oil, peppermint oil, and peppermint oil; citrus oils such as lemon oil, mandarin oil, lime oil, yuzu oil, grapefruit oil, and orange oil; and herb and spice oils such as sage oil, eucalyptus oil, clove oil, rosemary oil, thyme oil, nutmeg oil, laurel oil, basil oil, perilla oil, estragon oil, parsley oil, celery oil, coriander oil, fennel oil, cinnamon oil, pepper oil, nutmeg oil, mace oil, clove oil, ginger oil, cardamom oil, fennel oil, anise oil, cinnamon oil, wintergreen oil, clove oil, pimento oil, parsley oil, tea tree oil, tabana oil, and star anise oil.

These fat-soluble flavorings may be used alone or in combination of two or more. Furthermore, the fat-soluble flavoring may be a mixture of two or more single flavorings, one or more single flavorings and one or more essential oils, or two or more essential oils, which are blended to provide a desired fruit flavor.

Among these fat-soluble fragrances, preferred are menthol, geraniol, citronellol, limonene, linalool, citrus oils, herb and spice oils, etc.

The content of the fat-soluble flavor in the oral composition of the present invention is not particularly limited, but may be, for example, 0.01 to 5.0% by weight, preferably 0.1 to 2.5% by weight, and more preferably 0.5 to 1.5% by weight.

[Polar oil]
The oral composition of the present invention contains a polar oil (sometimes referred to as "component (B)"). The coexistence of an oil-soluble flavor and a polar oil makes it possible to improve the release and persistence of the aroma of the oil-soluble flavor.

Polar oil means an oil with an IOB (inorganic/organic balance) in the range of 0.05 to 1.1. The IOB of the polar oil used in the present invention is preferably 0.1 to 0.9, more preferably 0.15 to 0.5, and particularly preferably 0.3 to 0.4.

The viscosity of the polar oil used in the present invention is not particularly limited, but examples of the viscosity at 20°C include 5 to 600 mPa·s, preferably 40 to 550 mPa·s, and more preferably 140 to 510 mPa·s. In this specification, the viscosity of the polar oil refers to the value measured at a temperature of 20°C using a B-type viscometer "TOKI SANGYO VISCOMETER TVB-10" (manufactured by Toki Sangyo Co., Ltd.) with rotor No. 1 (rotation speed: 12 rpm, time: 30 sec, unit: mPa·s).

The type of polar oil is not particularly limited, as long as it can be applied to the oral cavity, but examples include fatty acid esters, higher fatty acids, higher alcohols, vegetable oils, etc.

Among polar oils, examples of fatty acid esters include esters of fatty acids and monohydric or polyhydric alcohols. Examples of fatty acid esters include monoesters in which one fatty acid molecule is bonded to one molecule of monohydric or polyhydric alcohol, diesters in which two fatty acid molecules are bonded to one molecule of polyhydric alcohol, triesters in which three fatty acid molecules are bonded to one molecule of trihydric or higher polyhydric alcohol, tetraesters in which four fatty acid molecules are bonded to one molecule of tetrahydric or higher polyhydric alcohol, diesters in which two monohydric alcohol molecules are bonded to one molecule of dicarboxylic acid, and cholesteryl fatty acids in which one fatty acid molecule is bonded to one molecule of cholesterol.

In monoesters in which one fatty acid molecule is bonded to one molecule of a monohydric or polyhydric alcohol, the carbon number of the constituent fatty acid is, for example, 4 to 30, preferably 6 to 20, and the carbon number of the constituent monohydric or polyhydric alcohol is, for example, 2 to 34, preferably 2 to 20. Specific examples of the monoesters include isopropyl myristate, octyldodecyl myristate, octyldodecyl oleate, dipentaerythritol fatty acid esters, isopropyl adipate, isobutyl adipate, isopropyl sebacate, cetyl ethylhexanoate, palmityl ethylhexanoate, myristyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, ethyl oleate, batyl stearate, hexyldecyl isostearate, isopropyl linoleate, cetyl octanoate, Examples include butyl stearate, ethyl laurate, hexyl laurate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, alkyl benzoate (carbon number 12 to 15), castor oil fatty acid methyl ester, oleyl oleate, 2-heptylundecyl palmitate, 2-hexyldecyl myristate, and 2-hexyldecyl palmitate.

In a diester in which two fatty acid molecules are bonded to one polyhydric alcohol molecule, the carbon number of the constituent fatty acid is, for example, 4 to 30, preferably 6 to 18, and the carbon number of the constituent polyhydric alcohol is, for example, 2 to 34, preferably 2 to 6. Specific examples of the diester include propylene glycol dicaprylate, neopentyl glycol dioctanoate, neopentyl glycol diethylhexanoate, glycol diethylhexanoate, neopentyl glycol dicaprate, glycerin diheptylundecanoate, and butylene glycol di(caprylate/caprate).

In triesters in which three fatty acid molecules are bonded to one molecule of a trivalent or higher polyhydric alcohol, the carbon number of the constituent fatty acid is, for example, 4 to 30, preferably 6 to 18, and the carbon number of the constituent polyhydric alcohol is, for example, 2 to 34, preferably 3 to 6. Specific examples of the triesters include triethylhexanoin (glyceryl triethylhexanoate), diglyceryl triisostearate, tri(caprylic acid/capric acid)glyceryl, glyceryl triisopalmitate, glyceryl triisooctanoate, trimethylolpropane triethylhexanoate, trimethylolpropane triisostearate, trimethylolpropane triisostearate, glyceryl triisostearate, glycerin trimyristate, and tri-2-heptylundecanoic acid glyceride.

In a tetraester in which four fatty acid molecules are bonded to one molecule of a polyhydric alcohol having 4 or more valences, the carbon number of the constituent fatty acid is, for example, 4 to 30, preferably 6 to 10, and the carbon number of one constituent polyhydric alcohol is, for example, 2 to 34, preferably 4 to 8. Specific examples of the tetraester include pentaerythrityl tetraethylhexanoate and pentaerythrityl tetraoctanoate.

In a diester in which two molecules of a monohydric alcohol are bonded to one molecule of a dicarboxylic acid, the carbon number of the constituent fatty acid is, for example, 4 to 30, preferably 4 to 12, and the carbon number of the constituent monohydric or polyhydric alcohol is, for example, 2 to 34, preferably 2 to 20. Specific examples of the diester include diethyl sebacate, diisopropyl sebacate, di-2-ethylhexyl sebacate, diisostearyl malate, diethylhexyl naphthalene dicarboxylate, di-2-hexyldecyl adipate, di-2-heptylundecyl adipate, and di-2-ethylhexyl succinate.

In the case of fatty acid cholesteryl, the carbon number of the constituent fatty acid is, for example, 4 to 30, preferably 6 to 20. Specific examples of fatty acid cholesteryl include lanolin fatty acid cholesteryl, hydroxystearate, and macadamia nut fatty acid cholesteryl.

These fatty acid esters may be used alone or in combination of two or more.

Among the polar oils, examples of higher fatty acids include fatty acids having 8 to 30 carbon atoms, preferably 10 to 20 carbon atoms, such as lauric acid, myristic acid, palmitic acid, sebacic acid, oleic acid, stearic acid, and linoleic acid. These fatty acids may be used alone or in combination of two or more.

Among the polar oils, examples of higher alcohols include alcohols having a carbon number of preferably 12 to 22, such as lauryl alcohol, myristyl alcohol, palmityl alcohol, cetanol, oleyl alcohol, stearyl alcohol, isostearyl alcohol, cetostearyl alcohol, and behenyl alcohol. These higher alcohols may be used alone or in combination of two or more.

Among polar oils, vegetable oils refer to fats and oils extracted from plants that are liquid at room temperature, and mainly contain triglycerides in which fatty acids and glycerin are esterified, and are distinguished from essential oils used as fat-soluble fragrances (i.e., volatile components distilled from plants that have an aroma). Examples of vegetable oils include sunflower seed oil, jojoba seed oil, olive oil, coconut oil, palm oil, palm kernel oil, safflower oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, corn oil, rapeseed oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, and jojoba oil. These vegetable oils may be used alone or in combination of two or more.

These polar oils may be used alone or in combination of two or more.

Among these polar oils, from the viewpoint of further improving the fragrance and fragrance persistence of the oil-soluble fragrance, fatty acid esters and vegetable oils are preferred; more preferred are monoesters in which one fatty acid molecule is bonded to one molecule of monohydric or polyhydric alcohol, diesters in which two fatty acid molecules are bonded to one molecule of polyhydric alcohol, triesters in which three fatty acid molecules are bonded to one molecule of trihydric or higher polyhydric alcohol, and tetraesters in which four fatty acid molecules are bonded to one molecule of tetrahydric or higher polyhydric alcohol; and particularly preferred are isopropyl myristate, propylene glycol dicaprylate, triethylhexanoin, diglyceryl triisostearate, and pentaerythritol tetraethylhexanoate.

The content of polar oil in the oral composition of the present invention is not particularly limited, but may be, for example, 0.01 to 1.5% by weight. From the viewpoint of further improving the scent and persistence of the scent of the oil-soluble flavoring, the content of polar oil in the oral composition of the present invention is preferably 0.1 to 0.5% by weight, and more preferably 0.1 to 0.3% by weight.

In the oral composition of the present invention, the ratio of the oil-soluble flavoring to the polar oil is not particularly limited as long as it is within the range according to the content of each of the above-mentioned components, but from the viewpoint of further improving the fragrance and persistence of the fragrance of the oil-soluble flavoring, the polar oil is preferably 0.2 to 15,000 parts by weight, more preferably 1 to 1,000, even more preferably 5 to 500 parts by weight, and particularly preferably 10 to 300 parts by weight per 100 parts by weight of the oil-soluble flavoring.

[Monohydric lower alcohol]
The oral composition of the present invention preferably further contains a monohydric lower alcohol, which can further improve the fragrance and persistence of the oil-soluble flavor and also facilitate the solubilization or emulsification of the oil-soluble flavor and the polar oil.

The monohydric lower alcohol is not particularly limited, so long as it can be applied to the oral cavity, but examples include monohydric alcohols having 2 to 5 carbon atoms, preferably ethanol, propanol, isopropanol, and butanol, and more preferably ethanol.

These monohydric lower alcohols may be used alone or in combination of two or more.

When the oral composition of the present invention contains a monohydric lower alcohol, the content is not particularly limited, but may be, for example, 5 to 35% by weight, preferably 7.5 to 25% by weight, and more preferably 10 to 15% by weight.

When the oral composition of the present invention contains a monohydric lower alcohol, the ratio of the monohydric lower alcohol to the total amount of the oil-soluble flavoring and polar oil is not particularly limited as long as it is within the range according to the content of each of the above-mentioned components, but for example, the monohydric lower alcohol is 250 to 3500 parts by weight, preferably 250 to 2500 parts by weight, and more preferably 480 to 1500 parts by weight per 100 parts by weight of the total amount of the oil-soluble flavoring and polar oil.

[Surfactant]
The oral composition of the present invention desirably contains a surfactant in order to facilitate solubilization or emulsification of the oil-soluble flavor and polar oil, and to further improve the fragrant release and persistence of the fragrance of the oil-soluble flavor.

The surfactant used in the present invention may be any of nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants, as long as they are applicable to the oral cavity.

Examples of nonionic surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene alkyl ether, and lecithin derivatives.

Polyoxyethylene hydrogenated castor oil is a compound in which hydrogenated castor oil is etherified with a polyoxyethylene chain. The number of moles of ethylene oxide added to the polyoxyethylene chain in polyoxyethylene hydrogenated castor oil is, for example, 5 to 100, preferably 10 to 80, and more preferably 20 to 60. Specific examples of polyoxyethylene hydrogenated castor oil include PEG-5 hydrogenated castor oil, PEG-10 hydrogenated castor oil, PEG-20 hydrogenated castor oil, PEG-30 hydrogenated castor oil, PEG-40 hydrogenated castor oil, PEG-50 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-70 hydrogenated castor oil, PEG-80 hydrogenated castor oil, PEG-90 hydrogenated castor oil, and PEG-100 hydrogenated castor oil. Among these polyoxyethylene hydrogenated castor oils, from the viewpoint of more effectively solubilizing components (A) and (B) to enhance the effect of suppressing cloudiness while further improving storage stability at low temperatures, preferred are polyoxyethylene hydrogenated castor oils having an added mole number of ethylene oxide of 20 to 60, and even more preferred are PEG-50 hydrogenated castor oil and PEG-60 hydrogenated castor oil.

Polyoxyethylene polyoxypropylene alkyl ether is a compound in which a polyoxyethylene polyoxypropylene chain is ether-bonded to an alkyl group. The number of moles of ethylene oxide added to the polyoxyethylene polyoxypropylene chain is, for example, 2 to 100, preferably 10 to 80, and more preferably 20 to 40. The number of moles of propylene oxide added to the polyoxyethylene polyoxypropylene chain is, for example, 1 to 40, preferably 1 to 20, and more preferably 1 to 10. The number of carbon atoms in the alkyl group is, for example, 6 to 24, preferably 8 to 22, and more preferably 12 to 18. Specific examples of polyoxyethylene polyoxypropylene alkyl ethers include PPG-4 ceteth-1, PPG-4 ceteth-10, PPG-4 ceteth-20, PPG-8 ceteth-20, PPG-6 decyl tetradeceth-12, PPG-6 decyl tetradeceth-20, and PPG-6 decyl tetradeceth-30. Among these polyoxyethylene polyoxypropylene alkyl ethers, from the viewpoint of more effectively solubilizing the components (A) and (B) to enhance the effect of suppressing cloudiness while further improving storage stability at low temperatures, preferably polyoxyethylene polyoxypropylene alkyl ethers having an added mole number of ethylene oxide of 20 to 40, an added mole number of propylene oxide of 1 to 10, and an alkyl group having a carbon number of 12 to 18, and more preferably PPG-6 decyl tetradeceth-30, are mentioned.

Glycerol fatty acid esters are monoesters, diesters, or triesters of fatty acids and glycerol. Specific examples of glycerol fatty acid esters include glyceryl monomyristate, glyceryl monostearate, glyceryl monoisostearate, glyceryl monooleate, glyceryl dioleate, glyceryl trioleate, and glyceryl distearate.

Polyglycerol fatty acid esters are esters of fatty acids and polyglycerol. Specific examples of polyglycerol fatty acid esters include polyglyceryl-2 stearate (diglyceryl monostearate), polyglyceryl-2 oleate (diglyceryl monooleate), polyglyceryl-4 oleate (tetraglyceryl monooleate), polyglyceryl-10 oleate (decaglyceryl monooleate), polyglyceryl-10 trioleate (decaglyceryl trioleate), polyglyceryl-10 palmitate (decaglyceryl monopalmitate), and polyglyceryl-2 oleate (decaglyceryl monooleate). glyceryl), polyglyceryl-2 isostearate, polyglyceryl-2 triisostearate, polyglyceryl-4 stearate, polyglyceryl-6 tristearate, polyglyceryl-10 pentastearate, polyglyceryl-10 pentahydroxystearate, polyglyceryl-10 pentaisostearate, polyglyceryl-10 pentaoleate, polyglyceryl-6 polyricinoleate, polyglyceryl-10 polyricinoleate, etc.

Sorbitan fatty acid esters are monoesters, diesters, or triesters of fatty acids and sorbitan. Specific examples of sorbitan fatty acid esters include sorbitan monostearate, sorbitan monoisostearate, sorbitan sesquiisostearate, sorbitan sesquioleate, sorbitan monooleate, sorbitan trioleate, sorbitan monopalmitate, and sorbitan monolaurate.

Sucrose fatty acid esters are esters of fatty acids and sucrose. Specific examples of sucrose fatty acid esters include sucrose stearate, sucrose erucate, sucrose laurate, sucrose behenate, sucrose palmitate, and sucrose oleate.

Polyoxyethylene glycol fatty acid esters are esters of fatty acids and polyethylene glycol. Specific examples of polyoxyethylene glycol fatty acid esters include PEG-10 laurate, PEG-10 stearate, PEG-25 stearate, and PEG-40 stearate.

Polyoxyethylene sorbitan fatty acid esters are compounds in which ethylene oxide is condensed with sorbitan fatty acid esters. Specific examples of polyoxyethylene sorbitan fatty acid esters include PEG-20 sorbitan cocoate, polysorbate 40, polysorbate 60, PEG-6 sorbitan stearate, polysorbate 65, PEG-20 sorbitan isostearate, polysorbate 80, PEG-6 sorbitan oleate, and polysorbate 85.

Polyoxyethylene sorbitol fatty acid esters are compounds in which ethylene oxide is condensed with sorbitol fatty acid esters. Specific examples of polyoxyethylene sorbitol fatty acid esters include sorbeth-6 laurate, sorbeth-60 tetrastearate, sorbeth-6 tetraoleate, sorbeth-30 tetraoleate, sorbeth-40 tetraoleate, sorbeth-60 tetraoleate, and sorbeth-30 tetraisostearate.

Polyoxyethylene alkyl ethers are compounds in which a polyoxyethylene chain and an alkyl group are ether-bonded. Specific examples of polyoxyethylene alkyl ethers include polyoxyethylene lauryl ether, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene oleyl ether, polyoxyethylene behenyl ether, and polyoxyethylene decyl tetradecyl ether.

Specific examples of lecithin derivatives include hydrogenated lecithin and hydrogenated lysolecithin.

Specific examples of anionic surfactants include sodium polyoxyethylene lauryl ether sulfate, sodium lauryl sulfate, sodium myristyl sulfate, sodium N-lauroyl sarcosinate, sodium N-myristyl sarcosinate, sodium dodecylbenzenesulfonate, sodium hydrogenated coconut fatty acid monoglyceride monosulfate, sodium lauryl sulfoacetate, sodium α-olefin sulfonate, sodium N-palmitoyl glutamate, and sodium N-methyl-N-acyltaurate.

Specific examples of cationic surfactants include lauryl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, benzethonium chloride, benzalkonium chloride, and stearyl dimethyl benzyl ammonium chloride.

Specific examples of amphoteric surfactants include coconut oil fatty acid amidopropyl betaine, lauryl dimethylaminoacetate betaine, lauryl dimethylamine oxide, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, N-lauryl diaminoethyl glycine, N-myristyl diaminoethyl glycine, N-alkyl-1-hydroxyethyl imidazoline sodium betaine, and lecithin.

These surfactants may be used alone or in combination of two or more.

Among these surfactants, from the viewpoint of more effectively solubilizing fat-soluble fragrances and polar oils while further improving the fragrance release and persistence of the oil-soluble fragrance, surfactants with an HLB value of about 8 to 17 are preferred. In the present invention, the HLB value of the surfactant is a value calculated according to the Kawakami method (HLB value = 7 + 11.7 log (sum of formula weights of hydrophilic parts / sum of formula weights of lipophilic parts)).

As the surfactant, from the viewpoint of stably solubilizing the fat-soluble fragrance and polar oil while further improving the fragrance and persistence of the oil-soluble fragrance, preferably, a nonionic surfactant is used, and more preferably, polyoxyethylene hydrogenated castor oil and/or polyoxyethylene polyoxypropylene alkyl ether.

In particular, by using a combination of polyoxyethylene hydrogenated castor oil and polyoxyethylene polyoxypropylene alkyl ether as a surfactant, it is possible to stably solubilize fat-soluble fragrances and polar oils while significantly improving the fragrance release and persistence of the oil-soluble fragrance. When using a combination of polyoxyethylene hydrogenated castor oil and polyoxyethylene polyoxypropylene alkyl ether, the ratio of the two is not particularly limited, but for example, 5 to 150 parts by weight, preferably 7 to 100 parts by weight, and more preferably 10 to 50 parts by weight of polyoxyethylene polyoxypropylene alkyl ether per 100 parts by weight of polyoxyethylene hydrogenated castor oil can be mentioned.

When a surfactant is contained in the oral composition of the present invention, the content may be appropriately set depending on the type of surfactant used, and may be, for example, 1 to 5% by weight, preferably 1.5 to 4.5% by weight, and more preferably 2 to 4% by weight.

When a surfactant is contained in the oral composition of the present invention, the ratio of the surfactant to the total amount of the oil-soluble flavoring and polar oil is not particularly limited as long as it is within the range according to the content of each of the above-mentioned components, but for example, the surfactant may be 50 to 500 parts by weight, preferably 50 to 400 parts by weight, and more preferably 100 to 300 parts by weight, per 100 parts by weight of the total amount of the oil-soluble flavoring and polar oil.

[Polyhydric alcohol]
The oral composition of the present invention preferably further contains a polyhydric alcohol, which can further improve the fragrance and persistence of the oil-soluble flavor and can facilitate the solubilization of the oil-soluble flavor and the polar oil.

The polyhydric alcohols used in the present invention are not particularly limited, so long as they are applicable to the oral cavity, but examples include ethylene glycol, 1,3-butylene glycol, propylene glycol, isoprene glycol, diethylene glycol, dipropylene glycol, polypropylene glycol, glycerin, etc.

These polyhydric alcohols may be used alone or in combination of two or more.

Among these polyhydric alcohols, glycerin is preferred from the viewpoint of further improving the fragrance and persistence of the fragrance of the oil-soluble fragrance.

When the oral composition of the present invention contains a polyhydric alcohol, the content is not particularly limited, but may be, for example, 5 to 35% by weight, preferably 7.5 to 35% by weight, and more preferably 10 to 25% by weight.

When the oral composition of the present invention contains a polyhydric alcohol, the ratio of the polyhydric alcohol to the total amount of the oil-soluble flavoring and polar oil is not particularly limited as long as it is within the range according to the content of each of the above-mentioned components, but for example, the polyhydric alcohol is 250 to 3500 parts by weight, preferably 250 to 3500 parts by weight, and more preferably 500 to 2500 parts by weight, per 100 parts by weight of the total amount of the oil-soluble flavoring and polar oil.

[water]
The oral composition of the present invention preferably contains water as a base. The content of water in the oral composition of the present invention is appropriately set depending on the formulation form, etc., and may be, for example, 30 to 85% by weight, preferably 40 to 75% by weight, and more preferably 50 to 70% by weight.

[Other ingredients]
In addition to the above-mentioned components, the oral composition of the present invention may contain components commonly used in the art according to the formulation of the oral composition, so long as the effects of the present invention are not impaired. Examples of such components include preservatives, bactericides, antibacterial agents, anti-inflammatory agents, abrasives, glucosyltransferase (GTase) inhibitors, plaque inhibitors, hypersensitivity inhibitors, tartar prevention agents, tooth strengthening/remineralization agents, local anesthetics, blood circulation promoters, thickeners, humectants, sweeteners, colorants, deodorants, pH adjusters, etc.

Examples of preservatives, disinfectants, and antibacterial agents include hinokitiol, benzoic acids, salicylic acids, sorbic acids, parabens, chlorhexidine chloride, chlorhexidine gluconate, isopropyl methylphenol, triclosan, lysozyme chloride, chlorhexidine hydrochloride, and potassium iodide.

Examples of anti-inflammatory agents include dipotassium glycyrrhizinate, glycyrrhetinic acid, methyl glycyrrhizinate, stearyl glycyrrhizinate, pyridoxine glycyrrhetinate, stearyl glycyrrhetinate, glyceryl glycyrrhetinate, glycyrrhetinic acid monoglucuronide, allantoin, tranexamic acid, epsilon aminocaproic acid, azulene, sodium chloride, vitamins, etc.

Examples of abrasives include anhydrous silicic acid, hydrous silicic acid, aluminum oxide, aluminum hydroxide, calcium hydrogen phosphate, calcium phosphate, calcium pyrophosphate, calcium carbonate, crystalline cellulose, polyethylene powder, and charcoal particles.

GTase inhibitors include, for example, extracts of plants of the genus Oenothera in the Onagraceae family, extracts of plants of the genus Vitis in the Vitaceae family, dextranase, mutanase, tastein, tannins, ellagic acid, polyphenols, oolong tea extract, green tea extract, Swertia japonica, Chinese laurel, fennel, peony root, gentiana, Chinese laurel, gentian, Coptis chinensis, and the like.

Examples of plaque inhibitors include zinc citrate and gluconic acid.

Examples of anti-dentin hypersensitivity agents include potassium nitrate and strontium chloride.

Examples of anti-tartar agents include polyphosphates, zeolites, and ethanehydroxydiphosphonate.

Examples of tooth strengthening/remineralizing agents include fluoride, sodium fluoride, sodium fluorophosphate, stannous fluoride, etc.

Local anesthetics include, for example, procaine, tetracaine, bupivacaine, mepipacaine, chloroprocaine, proparacaine, meprylcaine or salts thereof, orthocaine, oxethazaine, oxypolyethyleneoxydecane, Scopolia extract, percaminepase, and tesitdesitin.

Examples of blood circulation promoters include vanillylamide nonyl acid, benzyl nicotinate, capsaicin, and chili pepper extract.

Examples of thickening agents include polysaccharides such as pullulan, pullulan derivatives, and starch; hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl methyl cellulose, carboxymethyl cellulose, carboxymethyl cellulose salts (sodium carboxymethyl cellulose, potassium carboxymethyl cellulose, etc.), methyl cellulose, ethyl cellulose, polyacrylic acid, polyacrylates (sodium polyacrylate, acrylic acid/octyl acrylate copolymer, etc.), copolymers of methacrylic acids (methacrylic acid and acrylic acid Examples of such polymers include cellulose-based polymers such as n-butyl polymers, polymers of methacrylic acid and methyl methacrylate, and polymers of methacrylic acid and ethyl acrylate; synthetic polymers such as carboxyvinyl polymers, polyethylene glycol, polyvinyl alcohol, and polyvinylpyrrolidone; natural polymers such as lectin, alginic acid, alginates (sodium alginate, potassium alginate, magnesium alginate, propylene glycol alginate, triethanolamine alginate, triisopropanolamine alginate, ammonium alginate, butylamine alginate, diamylamine alginate, etc.), sodium chondroitin sulfate, agar, chitosan, and carrageenan; amino acid polymers such as collagen and gelatin; and rubber-based polymers such as gum arabic, karaya gum, tragacanth gum, xanthan gum, locust bean gum, guar gum, tamarind gum, and gellan gum.

Examples of humectants include xylitol, maltitol, lactol, and erythritol.

Sweetening agents include sodium saccharin, stevioside, stevia extract, aspartame, xylitol, starch syrup, honey, sorbitol, maltitol, mannitol, erythritol, and sugars (lactose, sucrose, fructose, glucose, etc.).

Dyes include, for example, natural dyes, synthetic dyes, and mixtures thereof.

Examples of deodorants include zinc chloride, sodium copper chlorophyllin, green coffee bean extract, burdock powder, green tea, roasted rice bran extract, etc.

Examples of pH adjusters include acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, malic acid, lactic acid, phosphoric acid, benzoic acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium citrate, sodium hydrogen citrate, sodium lactate, calcium lactate, sodium phosphate, sodium hydrogen phosphate, and sodium benzoate.

When these components are contained in the oral composition of the present invention, their contents may be appropriately set within the ranges normally used in the relevant technical field.

[Dosage form/formulation]
In the oral compositions of the present invention, the fat-soluble flavor and polar oil may be present in either a solubilized or emulsified state.

The dosage form of the oral composition of the present invention is not particularly limited as long as it can be applied to the oral cavity, but examples of the dosage form include liquid and semi-solid (gel, paste) forms.

The formulation of the oral composition of the present invention is not particularly limited as long as it can be applied to the oral cavity and remain there for a certain period of time, but examples include oral hygiene agents such as liquid dentifrice, liquid dentifrice, toothpaste, mouthwash (liquid dentifrice and mouthwash are generally sometimes called mouth rinse, mouthwash, dental rinse, etc.), mouth fresheners (mouth spray, etc.), and oral ointments. Among these, liquid dentifrice, mouthwash, etc. are preferred, and mouth rinse, mouth spray, etc. are more preferred.

[Production method]
The oral composition of the present invention can be manufactured according to the known formulation method of solubilized preparation or emulsified preparation.For example, the oral composition of the present invention can be manufactured by adding other components that are added as necessary together with fat-soluble flavoring and polar oil in an appropriate order and mixing them.If fat-soluble flavoring and polar oil are not solubilized or emulsified by mixing alone, it is sufficient to use a homogenizer or the like to stir them.

2. Method for Improving Fragrance Release and Fragrance Durability The present invention further provides a method for improving the fragrance release and fragrance durability of an oil-soluble flavor in an oral composition containing an oil-soluble flavor, the method comprising blending an oil-soluble flavor and a polar oil into the oral composition.

In the method of the present invention, the type and content of the oil-soluble flavor and polar oil, other ingredients and their contents, and the dosage form and formulation of the oral composition are as described in the section "1. Oral Composition" above.

The present invention will be explained in more detail below with reference to examples, but the present invention is not limited to these.

The IOB values and viscosities at 20° C. of the fatty acid esters used in the following Examples, Comparative Examples, and Formulation Examples are as follows.
Propylene glycol dicaprylate: IOB value 0.18, viscosity 8 mPa·s
Isopropyl myristate: IOB value 0.32, viscosity 11 mPa·s
Triethylhexanoin: IOB value 0.35, viscosity 43 mPa·s
Pentaerythritol tetraethylhexanoate: IOB value 0.35, viscosity 140 mPa·s
Diglyceryl triisostearate: IOB value 0.26, viscosity 510 mPa·s

The IOB value and viscosity at 20°C of triglycerides, which are the main components of the vegetable oils (sunflower seed oil, olive oil) used in the examples below, are 0.18 and 46 mPa·s, respectively.

Test Example 1
Mouthwashes were prepared with the compositions shown in Tables 1 to 3. Specifically, ethanol and a surfactant were first mixed, to which an oil-soluble flavoring and a polar oil or a non-polar oil were added and mixed, and then water, glycerin, and sodium saccharin were added and mixed to prepare the mouthwashes.

The resulting mouthwashes were evaluated for the release of the fat-soluble flavoring and the persistence of the scent using the following method: Immediately after preparation, each mouthwash was filled into a spray container and sprayed three times (approximately 1.0 ml) into the mouths of five panelists (who had previously brushed their teeth for three minutes without toothpaste), and the release of the scent and the persistence of the scent were scored according to the following criteria.
<Criteria for judging the aroma release of fat-soluble fragrances>
5: Immediately after spraying into the mouth, a very strong scent is felt.
4: A strong scent is felt immediately after spraying into the mouth.
3: A moderate fragrance is felt immediately after spraying into the mouth.
2: Immediately after spraying into the mouth, the scent is weak but definitely detectable.
1: Immediately after spraying into the mouth, a very weak fragrance is detected.
0: Almost no scent is detected immediately after spraying into the oral cavity.
<Criteria for determining the duration of the fragrance of fat-soluble fragrances>
5: A very strong scent is felt 10 minutes after spraying into the mouth.
4: A strong odor is felt 10 minutes after spraying into the mouth.
3: A moderate fragrance is felt 10 minutes after spraying into the mouth.
2: 10 minutes after spraying into the mouth, the scent is weak but definitely detectable.
1: 10 minutes after spraying into the mouth, a very weak fragrance is detectable.
0: 10 minutes after spraying into the mouth, the scent is barely perceptible.

Furthermore, the scores judged by each panelist were averaged, and the evaluation results were summarized according to the classification criteria shown below.
<Scoring criteria>
+++: Average score is 3 or more points.++: Average score is 2 or more points but less than 3 points.+: Average score is 1 or more points but less than 2 points.-: Average score is less than 1 point.

The results are shown in Tables 1 to 3. As a result, when neither polar oil nor non-polar oil was included (Comparative Examples 1 and 2), the fragrance of the oil-soluble fragrance was hardly noticeable. Furthermore, when the oil-soluble fragrance and non-polar oil were used in combination (Comparative Examples 3 and 4), although the fragrance persistence was improved, the fragrance was insufficient. In contrast, when the oil-soluble fragrance and polar oil were used in combination (Examples 1 to 16), the fragrance and fragrance persistence were excellent. Furthermore, as is clear from a comparison between Examples 10 and 14, it was found that when a monohydric lower alcohol and a polyhydric alcohol were included in addition to a polar oil, the fragrance and fragrance persistence were further improved.

Mouthwashes having the compositions shown in Formulation Example 4 were prepared in the same manner as in Test Example 1. All of the obtained mouthwashes had excellent fragrance and fragrance persistence.

Claims (3)

An oil-soluble fragrance;
at least one polar oil selected from the group consisting of isopropyl myristate, propylene glycol dicaprylate, triethylhexanoin, diglyceryl triisostearate, and pentaerythritol tetraethylhexanoate;
10 to 25% by weight of a polyhydric alcohol;
10 to 15% by weight of a monohydric alcohol having 2 to 5 carbon atoms ;
A surfactant,
Water,
An oral composition comprising the above (excluding those containing an anionic surfactant and those containing 4-isopropyl-3-methylphenol). The oral composition according to claim 1, which contains 0.01% by weight or more of the polar oil. A method for improving the fragrance and persistence of a fragrance of an oil-soluble flavor in an oral composition containing an oil-soluble flavor (excluding cases where the composition contains an anionic surfactant and where the composition contains 4-isopropyl-3-methylphenol), comprising:
The method comprises blending an oil-soluble flavoring, at least one polar oil selected from the group consisting of isopropyl myristate, propylene glycol dicaprylate, triethylhexanoin, diglyceryl triisostearate, and pentaerythritol tetraethylhexanoate, 10 to 25% by weight of a polyhydric alcohol, 10 to 25% by weight of a monohydric alcohol having 2 to 5 carbon atoms , a surfactant, and water into an oral composition (excluding those containing an anionic surfactant and those containing 4-isopropyl-3-methylphenol).