JP6841222B2 - Saliva secretion promoter, xerostomia inhibitor and oral moisturizer, and composition - Google Patents

Description

The present invention relates to a saliva secretion-promoting agent, a xerostomia inhibitor, an oral moisturizing agent, and a composition.

In dry mouth, the amount of saliva produced is reduced and the quality of saliva is abnormal, and thirst and dry mouth are caused, causing pain and discomfort. It is accompanied by sticky discomfort, difficulty in conversation, and the occurrence of bad breath. When it becomes more morbid, changes in the oral flora cause not only oral function but also general health deficiency such as caries, periodontal disease, and various infectious diseases.

As a symptomatic treatment, moisturizing the oral cavity with artificial saliva, an oral moisturizer / moisturizer, etc. can be mentioned, but it is not a fundamental solution. For this reason, it is important to promote saliva secretion and moisturize the oral cavity in order to keep the oral cavity refreshed and prevent oral diseases and systemic diseases. Examples of the saliva secretion-promoting agent include polyglutamic acid and salts thereof, and a technique having a more excellent saliva secretion-promoting effect has been desired.

Special Table 2010-520913 Japanese Unexamined Patent Publication No. 2008-24620 Japanese Unexamined Patent Publication No. 2006-117563 Japanese Unexamined Patent Publication No. 2000-239136 International Publication No. 2005/049050

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a saliva secretion-promoting agent, a xerostomia inhibitor, an oral moisturizing agent, and oral and oral compositions effective for improving dry mouth.

As a result of diligent studies to achieve the above object, the present inventors promote saliva secretion by using polyglutamic acid and / or a salt thereof in combination with an extract of Cape gorses linearis, and the mouth. It has been found that the drying inside is softened and the sticky discomfort is removed, which led to the present invention.

Therefore, the present invention provides the following agents and compositions.
[1]. A saliva secretion-promoting agent containing (A) polyglutamic acid and / or a salt thereof and (B) an extract of Cape gorses linearis as an active ingredient.
[2]. An xerostomia inhibitor containing (A) polyglutamic acid and / or a salt thereof and (B) an extract of Cape gorses linearis as an active ingredient.
[3]. An oral moisturizing agent containing (A) polyglutamic acid and / or a salt thereof and (B) an extract of Cape gorses linearis as an active ingredient.
[4]. An oral composition or an oral composition containing (A) polyglutamic acid and / or a salt thereof, and (B) an extract of Cape gorses linearis.
[5]. An oral composition for promoting saliva secretion or an oral composition for promoting saliva secretion, which comprises (A) polyglutamic acid and / or a salt thereof and (B) an extract of Asparasus linearis as an active ingredient.
[6]. An oral composition for suppressing xerostomia or an oral composition for suppressing xerostomia, which comprises (A) polyglutamic acid and / or a salt thereof and (B) an extract of Cape gorses linearis as an active ingredient.
[7]. Oral composition for oral moisturizing or oral composition for oral moisturizing, which contains (A) polyglutamic acid and / or a salt thereof and (B) an extract of Cape gorses linearis as an active ingredient. Stuff.
[8]. The content of (A) polyglutamic acid and / or a salt thereof is 0.001 to 50% by mass, and the content of (B) Cape gorses linearis extract is 0.0001 to 80% by mass. The composition according to any one of [4] to [7].

According to the present invention, it is possible to provide a saliva secretion promoter, an xerostomia inhibitor, an oral moisturizing agent, and an oral and oral composition effective for improving dry mouth.

It is a graph which shows the saliva secretion-promoting action of polyglutamic acid and / or a salt thereof, and the extract of Cape gorses linearis. It is a graph which shows the effect of suppressing dry mouth and the effect of imparting moisture in the oral cavity between polyglutamic acid and / or a salt thereof and an extract of Cape gorses linearis.

Hereinafter, the present invention will be described in detail.
The present invention provides a saliva secretion-promoting agent, a xerostomia inhibitor, and an oral moisturizing agent containing (A) polyglutamic acid and / or a salt thereof and (B) an extract of Cape gorses linearis as an active ingredient. Provide the agent.

[(A) Polyglutamic acid and / or a salt thereof]
As the polyglutamic acid, chemically synthesized α or γ-polyglutamic acid, natural α or γ-polyglutamic acid obtained as a fermentation product from various strains, or a salt thereof can be used. In this case, natural polyglutamic acid is preferable because it is blended in oral compositions and foods, and γ-polyglutamic acid, which can be mass-produced industrially, is most preferable. Polyglutamic acid may be D-form or L-form. Polyglutamic acid is insoluble in water, but becomes water-soluble when salted. Examples of the salt at this time include sodium salt, potassium salt, magnesium salt, calcium salt, ammonium salt, ethanolamine salt, basic amino acid salt and the like, but sodium or potassium salt is preferable. The degree of neutralization of the salt used in the present invention can be arbitrarily selected according to the purpose of the aqueous solution having a concentration of 1% by mass in the range of pH 1 to pH 14.

The viscosity of polyglutamic acid or a salt thereof is not particularly limited, and various viscosities can be used depending on the type of product, but the viscosity of the 4% by mass aqueous solution measured by the method described later is preferably 10 to 200 mPa · s. , 30 to 120 mPa · s is more preferable.

<Viscosity measurement method>
Take 96 g of water in a 200 mL beaker and add 4.0 g of polyglutamic acid or a salt thereof while stirring with a stirrer to completely dissolve it. Next, after allowing to stand in a constant temperature water bath at 25 ° C. for 1 hour, the viscosity after 1 minute is accurately measured using the following BL type viscometer.
BL type viscometer: Tokyo Keiki: B type viscometer, model: BL, rotor: No. 2. Rotation speed: 60 rpm, measurement temperature: 25 ° C

Commercially available products can be used as polyglutamic acid or a salt thereof, and for example, Meiji polyglutamic acid manufactured by Meiji Food Materia Co., Ltd. can be used as sodium γ-polyglutamic acid.

[(B) Asparagus linearis extract]
Cape gorses linearis is also called rooibos (hereinafter, may be abbreviated as "rooibos") and belongs to the genus Cape gorses (Fabaceae). The rooibos extract can be easily obtained by a method generally used for extracting plants, and the extraction method is not particularly limited as long as the effects of the present invention can be obtained. In addition, commercially available rooibos tea extract powder can be used.

The extraction site of rooibos is not particularly limited and can be appropriately selected. For example, a leaf part, a young leaf part, a branch part, a trunk part, a bark part, a flower part, a fruit part, a root part and the like can be mentioned. Among these, young leaves and branches are preferable.

The rooibos used for extraction can be either fermented or unfermented. Fermented products are those produced through an oxidation process, and unfermented products are those produced through this oxidation process, that is, those that are not fermented. The oxidation process of fermentation is not particularly limited, and a commonly used method can be used. For example, it refers to an oxidation process in which water is contained and incubated at 20 to 40 ° C., or an oxidation process in sunlight.

The rooibos extract can be obtained by further pulverizing using a coarse crusher, drying, or combining these and then subjecting them to solvent extraction described later. The drying treatment is not particularly limited, and a generally used method can be used. For example, it is preferable to carry out at 60 ° C. or lower.

The extraction method is not particularly limited and can be appropriately selected. For example, the extract is prepared by putting the extraction site of Louis Boss, which is an extraction raw material, into a treatment tank filled with an extraction solvent, eluting the soluble components with appropriate stirring as necessary, and then filtering to remove the extraction residue. Obtainable.

The extraction solvent is not particularly limited and can be appropriately selected. For example, water, a hydrophilic solvent, a hydrophobic solvent, or a mixed solvent thereof can be mentioned. Examples of water include pure water, tap water, well water, mineral spring water, mineral water, hot spring water, spring water, fresh water, purified water, hot water, ion-exchanged water, physiological saline, phosphate buffer, phosphate buffered physiology. Examples include saline solution. Examples of the hydrophilic solvent include lower alcohols having 1 to 6 carbon atoms such as methanol, ethanol, propyl alcohol and isopropyl alcohol; lower aliphatic ketones such as acetone and methyl ethyl ketone; 1,3-butylene glycol, propylene glycol and glycerin. Examples thereof include polyhydric alcohols having 2 to 6 carbon atoms. Examples of the hydrophobic solvent include aromatic carbons such as benzene and toluene; organic solvents such as ethyl acetate, acetonitrile and ether; and halogenated carbons such as dichloromethane and chloroform. The mixed solvent is not particularly limited, and the above-mentioned water, the above-mentioned hydrophilic solvent and the like can be appropriately mixed and used. As for the ratio of the mixed solvent, it is preferable to add 1 to 90 parts by mass of each of a lower alcohol, a lower aliphatic ketone, a polyhydric alcohol and the like with respect to 10 parts by mass of water. As the extraction solvent, water, ethanol, or a mixed solution of water and ethanol is preferable, 0 to 20% by mass ethanol aqueous solution is more preferable, and water is further preferable.

The amount of the extraction solvent used is not particularly limited and can be appropriately selected depending on the extraction solvent, the extraction method and the like. For example, 1 to 1,000 parts by mass of the extraction solvent can be used with respect to 1 part by mass of the extraction site.

The extraction conditions (extraction time and extraction temperature) are not particularly limited and can be appropriately selected depending on the extraction method such as the extraction solvent. When the solvent is water, the extraction temperature is preferably room temperature to hot water, more preferably hot water.

The rooibos extract can be purified and used as needed, and the purification method is not particularly limited and can be appropriately selected. For example, purification methods such as liquid-liquid partition extraction, various chromatographies, membrane separation, and supercritical fluid extraction can be mentioned.

The specific embodiment of the Louis Boss extract is not particularly limited and may be appropriately selected. For example, the extract itself, the dried extract of the extract, the diluted solution of the extract, the dried product of the diluted solution of the extract, and the extract. A concentrated liquid (concentrated extract), a dried product of the concentrated liquid of the extract, a powder of the dried product, or the like can be used. As the extract, a water extract is preferable, and a hot water extract is particularly preferable.

As the rooibos extract, for example, a commercially available rooibos tea extract can also be used. Examples of the commercially available rooibos tea extract include powder obtained by filtering a hot water extract of fermented young leaves of rooibos and concentrating and drying the filtrate.

[Saliva secretion promoter]
The combination of the above (A) polyglutamic acid and / or a salt thereof and (B) rooibos extract can obtain a remarkable saliva secretion promoting effect that cannot be obtained by each alone. The present invention provides a saliva secretion-promoting agent containing this as an active ingredient.

[Xerostomia inhibitor]
The combination of (A) polyglutamic acid and / or a salt thereof and (B) rooibos extract gives a remarkable saliva secretion promoting effect that cannot be obtained by itself, and has an effect of suppressing dryness in the oral cavity. Be done. The present invention provides a xerostomia inhibitor containing this as an active ingredient.

[Moisturizer in the oral cavity]
The combination of (A) polyglutamic acid and / or a salt thereof and (B) rooibos extract gives a remarkable saliva secretion-promoting effect that cannot be obtained by itself, and a moisturizing effect in the oral cavity. The present invention provides an oral moisturizing agent containing this as an active ingredient.

The amount of (A) polyglutamic acid and / or a salt thereof, and (B) rooibos extract to each agent is appropriately selected depending on the dosage form, ingestion (administration) form, and ingestion (administration) target. The effective amount of each agent that exerts the desired effect such as saliva secretion promotion is as follows, and is appropriately selected from the condition and age of the ingestion (administration) target.

The effective amount of (A) polyglutamic acid and / or a salt thereof is preferably 0.01 to 5,000 mg / day, more preferably 0.05 to 1,000 mg / day, and 0, for example, per adult per day. .1-500 mg / day is more preferred. The number of times of ingestion (administration) is not limited, and the ingestion (administration) can be performed 1 to 20 times a day.

(B) In the case of a dried rooibos extract, the effective amount of the rooibos extract is, for example, preferably 1 to 10,000 mg / day, more preferably 10 to 1,000 mg / day, and further preferably 20 to 500 mg / day. preferable. Such an amount may be ingested (administered) once a day, or may be ingested (administered) in a plurality of times (1 to 20 times) a day. When ingested (administered) in multiple doses, it is preferably 5 to 50,000 mg / dose, more preferably 50 to 10,000 mg / dose, and 100 to 5,000 mg in terms of dried rooibos before extraction. / Time is more preferable.

The method of ingesting (administering) the agent of the present invention is not particularly limited, and may be oral or parenteral. The dosage form is not particularly limited, and solid, liquid, gel, cream, paste and the like can be appropriately selected. Of these, oral is preferable, and known dosage forms such as powders, tablets, orally disintegrating tablets, chewing tablets, capsules, films, sprays, and liquids can be selected. Further, the solid may be dissolved in a liquid such as water, or the liquid may be diluted with water and ingested (administered). Of these, orally disintegrating tablets, chewing tablets, and sprays are preferable.

[Oral or oral composition]
The present invention provides an oral or oral composition containing (A) polyglutamic acid and / or a salt thereof, and (B) an extract of Cape gorses linearis. As described above, since the above effects can be obtained by the combination of these, the above agent or Cape gorses linearis extract is used as an active ingredient for promoting saliva secretion, suppressing dry mouth, and imparting moisture in the oral cavity. It is suitable as an oral or oral composition.

The content of (A) polyglutamic acid and / or a salt thereof in the composition is preferably 0.001 to 50% by mass, more preferably 0.01 to 10% by mass. (B) The content (equivalent to dry matter) of the Cape gorses linearis extract is preferably 0.0001 to 80% by mass, more preferably 0.001 to 70% by mass, and 0.01 to 60%. Mass% is more preferred.

In the agent and composition of the present invention, (A): polyglutamic acid and / or a salt thereof / (B): component (A) represented by an extract of Cape gorses linearis (equivalent to a dried product). The compounding mass ratio of and the component (B) is preferably 0.001 to 1,000/1, more preferably 0.01 to 100/1. If this ratio is less than 0.001 / 1, the effect of suppressing xerostomia may be particularly inferior. On the other hand, if it is larger than 1,000/1, the effect of imparting moisture in the oral cavity may be inferior. As the dosage form, for solid preparations such as tablets such as orally disintegrating tablets and chewing tablets, 0.001 to 1,000/1 is preferable, 0.002 to 100/1 is more preferable, and 0.005- 10/1 is more preferable. For liquids such as sprays, 0.001 to 1,000/1 is preferable, 1 to 100/1 is more preferable, and 50 to 100/1 is even more preferable.

The oral composition is "mainly intended to be used in the oral cavity", and includes (i) ingestible and (ii) excreted after use. Specifically, (i) an ingestible substance includes a troche, an oral refreshing agent composition, and the like. (Ii) Toothpaste compositions such as dentifrices, liquid dentifrices, liquid dentifrices, and powdered dentifrices, mouthwash compositions, mouthwash compositions, and oral coatings compositions are discharged after use. , Oral pasta, dentifrice stabilizer composition and the like. However, the oral coating composition, oral pasta, etc. may include ingestible ones.

The oral composition is "mainly intended for oral ingestion" and is not particularly limited, and examples thereof include pharmaceuticals, foods for specified health uses, foods and the like. Foods for specified health use include candy, chewing gum, ramune, gummy, etc. that stay in the oral cavity for a long time, as well as beverages: soft drinks, carbonated drinks, nutritional drinks, powdered drinks, fruit drinks, dairy drinks, jelly drinks, etc. , Foods: Main foods (grains such as rice and wheat, noodles, bread, cereals, etc.), confectionery, dairy products, meat, fish, processed products such as vegetables and fruits, seasonings, etc. are not particularly limited.

The oral composition and the oral composition are each usual dosage form, and are not particularly limited, and solids, liquids, gels, creams, pastes and the like can be appropriately selected, and powders, tablets, orally disintegrating tablets and the like can be appropriately selected. , Chewing tablets, capsules, films, sprays and the like can be appropriately selected.

Among them, those that stay in the oral cavity for a long time are preferable, candy, chewing gum, ramune, and gummies are preferable, and the dosage form is preferably an orally disintegrating tablet, a chewing tablet, a spray agent, or the like.

In addition to the rooibos extract, the agent or composition of the present invention may contain a normal amount of any component used in each preparation or composition as long as the effects of the present invention are not impaired. Optional ingredients include, for example, excipients, diluents, buffers, fragrances, colorants, defoamers, coatings, flavoring agents, binders, surfactants, moisturizers, thickeners, lubricants, etc. Suspensions, preservatives, chelating agents, antioxidants, abrasives, thickeners, binders, pH regulators, brighteners, chemicals, solvents, etc., may be used alone or in combination of two or more. Can be used in appropriate combinations.

In particular, in the case of a liquid oral composition such as a mouthwash and a paste-like oral composition, a thickener, a binder, a surfactant and the like can be blended. In the case of a dentifrice composition, an abrasive may be blended. In the case of a liquid oral composition such as a spray agent, a surfactant, a solvent and the like can be blended.

The method of ingesting (administering) the agent and composition of the present invention is not particularly limited, and may be appropriately selected and may be used even when the oral cavity is dry, or the number of times per day may be determined. The number of times is not particularly limited, and is appropriately selected in the range of, for example, 1 to 20 times.

The present invention can further provide the following inventions. The optimum components, amounts, etc. are the same as above. (1) Use of polyglutamic acid and / or a salt thereof and an Asparatus linearis extract for producing the saliva secretion promoter, xerostomia inhibitor or oral moisturizing agent, (2) the above. The use of polyglutamic acid and / or a salt thereof and an Asparatus linearis extract for producing an oral composition or an oral composition, wherein the above composition contains the above saliva secretion promoter, xerostomia. Use characterized by blending an inhibitor or an oral moisture-imparting agent, (3) The saliva secretion-promoting agent, xerostomia inhibitor or oral moisture-imparting agent is blended with the above-mentioned oral composition or oral composition. A method of imparting a saliva secretion effect, an xerostomia-suppressing effect, or an oral moisturizing effect to the above-mentioned oral composition or oral composition.

Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In the following examples, unless otherwise specified, "%" of the composition indicates mass%, and the ratio indicates mass ratio.

[Test Example 1] Saliva secretion promoting action 20 mL of an aqueous solution (composition% (g / 100 mL)) having the composition shown in Table 1 below was contained in the mouth for 30 seconds and exhaled. Then, the amount of saliva secretion was measured by the saliva spitting method (measurement of saliva mass at rest for 30 minutes) (n = 5). The results (mean values) are shown in Table 1 and FIG. 1 below. The results are shown as 100% water (control). As sodium polyglutamate, γ-polyglutamate sodium (4% aqueous solution viscosity: 35.5 mPa · s (25 ° C)) manufactured by Meiji Food Materia Co., Ltd. is used, and the rooibos extract is rooibos tea extract powder manufactured by Maruzen Pharmaceutical Co., Ltd. MF (a powder obtained by filtering a hot water extract of rooibos fermented young leaves and concentrating and drying the filtrate, containing 10% rooibos extract and 90% dextrin) was used. The amount of rooibos extract in Table 1 is the amount converted to pure content (equivalent to dry mass).

[Test Example 2] Xerostomia-suppressing effect / oral moisturizing effect A sensory evaluation of the xerostomia-suppressing effect was performed using an aqueous solution having the above composition. Specifically, the evaluation was performed 30 minutes after the exhalation. The "feeling that the dry mouth was suppressed" was evaluated according to the following evaluation criteria. The results of the average values are shown in Table 1 and FIG.
<Evaluation criteria>
7 points; very felt / very moisturized 6 points; felt / moisturized 5 points; slightly felt / slightly moisturized 4 points; neither can be said / neither can be said 3 points 2 points that do not feel much / do not feel much moisture; 1 point that does not feel / do not feel moisture; do not feel at all / do not feel moisture at all

As is clear from the above results, the combination of polyglutamic acid and / or a salt thereof and rooibos extract has a remarkable effect of promoting saliva secretion, an effect of suppressing xerostomia, and an effect of imparting moisture in the oral cavity.

[Examples 1 to 13, Comparative Examples 1 to 3]
The tablets having the compositions shown in Tables 2 to 4 below were locked by a direct tapping method using a rotary locking machine (LIBURA2 manufactured by Kikusui Seisakusho Co., Ltd.). As the sodium polyglutamate component (A), Meiji polyglutamic acid (sodium γ-polyglutamate, 4% aqueous solution viscosity: 35.5 mPa · s (25 ° C.)) manufactured by Meiji Food Materia Co., Ltd. was used, and the above (B). As the fermented Louis Boss tea extract of the component), Maruzen Pharmaceutical Co., Ltd. Louis Boss Tea Dry Extract F (a powder obtained by filtering the hot water extract of fermented young leaves of Louis Boss and concentrating and drying the filtrate) is used, and the above (B) The unfermented Louis Boss tea extract of the component is a green Louis Boss extract manufactured by Tama Biochemical Co., Ltd. (a hot water extract of unfermented young leaves of Louis Boss is filtered, and the filtrate is concentrated and dried. % And 30% dextrin) were used. The amount of rooibos extract in the table is the amount converted to pure content (equivalent to dry mass). The obtained tablets were evaluated as follows.

[Test Example 3] Saliva secretion promoting action A sensory evaluation of saliva secretion promoting action (5 persons) was performed using a tablet. Specifically, one tablet was chewed and ingested, and the evaluation was performed 60 minutes after swallowing. "Feeling that saliva secretion was promoted" was evaluated according to the following evaluation criteria.
<Evaluation criteria>
⊚: 5 out of 5 responded that they felt that saliva secretion was promoted.
◯: 3 to 4 out of 5 responded that they felt that saliva secretion was promoted.
Δ: 1 to 2 out of 5 responded that they felt that saliva secretion was promoted.
×: 0 out of 5 responded that they felt that saliva secretion was promoted.

[Test Example 4] Xerostomia suppressing effect A sensory evaluation (5 persons) of the xerostomia suppressing effect was performed using a tablet. Specifically, one tablet was chewed and ingested, and the evaluation was performed 60 minutes after swallowing. "Feeling that dryness in the oral cavity is suppressed" was evaluated according to the following evaluation criteria.
<Evaluation criteria>
⊚: 5 out of 5 responded that they felt that the dryness in the oral cavity was suppressed.
◯: 3 to 4 out of 5 responded that they felt that the dryness in the oral cavity was suppressed.
Δ: 1 to 2 out of 5 responded that they felt that the dryness in the oral cavity was suppressed.
×: 0 out of 5 responded that they felt that the dryness in the oral cavity was suppressed.

[Test Example 5] Oral Moisturizing Effect A sensory evaluation (5 persons) of the oral moisturizing effect was performed using a tablet. Specifically, one tablet was chewed and ingested, and the evaluation was performed 60 minutes after swallowing. The "feeling of moisturizing the oral cavity" was evaluated according to the following evaluation criteria.
<Evaluation criteria>
⊚: 5 out of 5 responded that they felt that the oral cavity was moisturized.
◯: 3 to 4 out of 5 responded that they felt that the oral cavity was moisturized.
Δ: 1 to 2 out of 5 responded that they felt that the oral cavity was moisturized.
×: 0 out of 5 responded that they felt that the oral cavity was moisturized.

[Examples 14 to 25, Comparative Examples 4 to 5]
The spray agents having the compositions shown in Tables 5 to 7 below were prepared by weighing each component and mixing them with a stirrer. 30 g of the prepared liquid was filled in a spray container (Y-70 dispenser manufactured by Yoshino Kogyosho Co., Ltd., nozzle hole 0.55 mm, spray amount of 1 push was about 0.07 mL, capacity 30 mL polyethylene terephthalate bottle). The obtained spray agent was evaluated as follows.

[Test Example 6] Saliva secretion promoting action A sensory evaluation of saliva secretion promoting action (5 persons) was performed using a spray agent. Specifically, the test preparation was sprayed into the mouth of 5 pushes (about 0.35 mL), and the evaluation was performed 30 minutes later. "Feeling that saliva secretion was promoted" was evaluated according to the following evaluation criteria.
<Evaluation criteria>
⊚: 5 out of 5 responded that they felt that saliva secretion was promoted.
◯: 3 to 4 out of 5 responded that they felt that saliva secretion was promoted.
Δ: 1 to 2 out of 5 responded that they felt that saliva secretion was promoted.
×: 0 out of 5 responded that they felt that saliva secretion was promoted.

[Test Example 7] Xerostomia inhibitory effect A sensory evaluation (5 persons) of the xerostomia inhibitory effect was performed using a spray agent. Specifically, the test preparation was sprayed into the mouth of 5 pushes (about 0.35 mL), and the evaluation was performed 30 minutes later. "Feeling that dryness in the oral cavity is suppressed" was evaluated according to the following evaluation criteria.
<Evaluation criteria>
⊚: 5 out of 5 responded that they felt that the dryness in the oral cavity was suppressed.
◯: 3 to 4 out of 5 responded that they felt that the dryness in the oral cavity was suppressed.
Δ: 1 to 2 out of 5 responded that they felt that the dryness in the oral cavity was suppressed.
×: 0 out of 5 responded that they felt that the dryness in the oral cavity was suppressed.

[Test Example 8] Oral Moisturizing Effect A sensory evaluation (5 persons) of the oral moisturizing effect was performed using a spray agent. Specifically, the test preparation was sprayed into the mouth of 5 pushes (about 0.35 mL), and the evaluation was performed 30 minutes later. The "feeling of moisturizing the oral cavity" was evaluated according to the following evaluation criteria.
<Evaluation criteria>
⊚: 5 out of 5 responded that they felt that the oral cavity was moisturized.
◯: 3 to 4 out of 5 responded that they felt that the oral cavity was moisturized.
Δ: 1 to 2 out of 5 responded that they felt that the oral cavity was moisturized.
×: 0 out of 5 responded that they felt that the oral cavity was moisturized.

Similar to the above examples, the following examples showed excellent saliva secretion promoting effect, xerostomia suppressing effect, and oral moisturizing effect.

[Example 26]
Mouthwash (pH 7.5)
Composition (A) Sodium polyglutamate 0.1
(B) Fermented rooibos tea extract 0.01
Polyoxyethylene hardened castor oil (60) 0.5
Propylene glycol 3
Glycerin 4.5
Xylitol 3
Ethanol 2
Citric acid 0.07
Sodium citrate 0.25
Saccharin sodium 0.004
Fragrance 0.2
Purified water balance
Total 100.0%
(A) / (B) = 1/1

[Example 27]
Gum
Composition (A) Sodium polyglutamate 1.0
(B) Fermented rooibos tea extract 1.0
Gum base 19.6
Maltitol 22.8
Xylitol 19.6
Reduced starch syrup 1.3
Sucralose 0.07
Fragrance 1.96
(Sugar coating part)
Gum arabic 1.9
Dextranase preparation 0.1
Fragrance 0.2
Carnauba wax 0.04
Maltitol remnants
Total 100.0%
(A) / (B) = 1/1

As is clear from the above results, the combination of the polyglutamic acid and / or salt of the component (A) and the Louis Boss extract of the component (B) has a remarkable saliva secretion promoting effect and an oral dryness suppressing effect. An effect of imparting moisture in the oral cavity, an effect of moisturizing the oral cavity, and an effect of removing stickiness in the oral cavity were obtained.

Details of the various components used in the above Examples and the above Comparative Examples are shown in the table below. The amounts in the table are net conversion amounts.

Claims (8)

It contains (A) polyglutamic acid and / or a salt thereof, and (B) an extract of Cape gorses linearis, and is represented by (A) / (B), which corresponds to the component (A) and the dried product. An oral composition or an oral composition in which the blending mass ratio of the amount to the component (B) is 0.002 to 100. The oral composition or oral composition according to claim 1, which is for promoting saliva secretion. The oral composition or oral composition according to claim 1, which is for suppressing dry mouth. The oral composition or oral composition according to claim 1, which is for imparting moisture in the oral cavity. The content of (A) polyglutamic acid and / or a salt thereof is 0.001 to 50% by mass, and the content of (B) the dry matter equivalent of the extract of Cape gorses linearis is 0. The oral composition or oral composition according to any one of claims 1 to 4, which is 0001 to 80% by mass. It contains (A) polyglutamic acid and / or a salt thereof, and (B) an extract of Cape gorses linearis as an active ingredient, and is dried with the component (A) represented by (A) / (B). A saliva secretion-promoting agent having a compounding mass ratio of 0.002 to 100 with the equivalent amount of the component (B). It contains (A) polyglutamic acid and / or a salt thereof, and (B) an extract of Cape gorses linearis as an active ingredient, and is dried with the component (A) represented by (A) / (B). An oral dryness inhibitor having a compounding mass ratio of 0.002 to 100 with the equivalent amount of the component (B). It contains (A) polyglutamic acid and / or a salt thereof, and (B) an extract of Cape gorses linearis as an active ingredient, and is dried with the component (A) represented by (A) / (B). An oral moisturizing agent having a compounding mass ratio of 0.002 to 100 with the equivalent amount of the component (B).