JP6928593B2 - Oral composition - Google Patents

Description

The present invention relates to oral compositions.

Tooth enamel is composed of columns composed of hydroxyapatite polycrystals called enamel rods, and generally in younger age, the enamel rods and enamel rods of this enamel There is a space (gap) between them, that is, a column gap, which is filled with water, saliva components, and the like. Then, the incident light on the enamel is scattered due to the large difference in the refractive index between the enamel rod and the space between the trabeculae, so that the teeth appear white.

However, if substances dissolved in saliva continue to deposit in the interstitial space of the enamel surface of the tooth due to, for example, tooth stones, plaque, smoking, habitual eating and drinking such as coffee or tea, or aging, these small pillars The gaps are filled, resulting in a smaller difference in refractive index between the enamel rods and the gaps, which increases transparency in the enamel and allows incident light to reach the yellow or brown dentin located deep in the enamel. It becomes easier and the teeth appear yellowish.

Under these circumstances, phytic acid or a salt thereof is used in various oral compositions as a component that brings about a tooth whitening effect, a gloss-imparting effect, and the like. For example, Patent Document 1 discloses a composition for reforming a trabecular meshwork containing 0.05 to 18% by mass of phytic acid or a salt thereof and having a pH of 5.5 to 6.5. It selectively removes trabecular meshwork material to reshape the lost trabecular meshwork and enhance the tooth whitening effect. Further, Patent Document 2 discloses an oral composition in which phytic acid or a salt thereof is used in combination with pyrophosphate or a salt thereof, and exhibits an effect of removing minute stains adhering to the tooth surface and an effect of imparting luster. I'm trying.

On the other hand, Patent Document 3 discloses an oral composition in which phytic acid or a salt thereof is used in combination with tripolyphosphoric acid or a salt thereof, and by setting these to a specific mass ratio, the tooth enamel surface layer is small. Achieves both a selective effect of removing deposited dirt in the column gap and an effect of preventing the adhesion of deposited dirt.

JP-A-2009-263268 Japanese Unexamined Patent Publication No. 2012-219058 Japanese Unexamined Patent Publication No. 2018-65801

However, in order to more selectively and effectively remove the deposited dirt existing in the trabecular space of the enamel surface layer of the tooth and impart the beautiful luster inherent in the tooth, the technique described in the above patent document. Then, in each case, the pH of the composition has to be adjusted to a low range, and there is still room for improvement.

That is, the present invention more selectively and effectively removes the deposited stains existing in the trabecular space of the enamel surface layer of the tooth, and effectively prevents new deposited stains from adhering to the teeth. The present invention relates to an oral composition which can be used and does not require adjustment to a low pH range.

Therefore, as a result of various studies, the present inventor used phytic acid or a salt thereof in combination with glycerin together with tripolyphosphate, and by having a specific quantitative relationship between them having a very limited specific quantitative relationship, the pH was more than 6.5, but the pH was higher than 6.5. It has been found that an oral composition capable of further enhancing the effect of removing deposited stains in the trabecular space of the tooth enamel surface layer and its selectivity can be obtained.

Therefore, in the present invention, the following components (A) to (C):
(A) Phytic acid or a salt thereof (B) Tripolyphosphoric acid or a salt thereof (C) Glycerin Contains 8% by mass or more and 40% by mass or less, and the mass of the content of the component (C) and the content of the component (B). The ratio ((C) / (B)) is 25 or more and 80 or less, and the mass ratio of the content of the component (A) and the total content of the component (B) to the content of the component (C) ({( A) + (B)} / (C)) is 0.025 or more and 0.08 or less.
Does not contain one or more polyvalent metals selected from copper, iron, calcium, magnesium, aluminum, zinc, and tin or salts thereof (D), or components relative to the content of component (A). It provides an oral composition containing less than 0.1 times by molar (D) and having a pH of more than 6.5 at 25 ° C.

According to the oral composition of the present invention, the deposited stains existing in the trabecular meshwork of the tooth enamel surface layer are more selectively and effectively removed while the pH at 25 ° C. is more than 6.5. be able to. Therefore, even if the pH of the composition is not adjusted to a low range, the appearance of harmful effects on the tooth surface can be suppressed, the original beautiful luster of the tooth can be imparted, and new stains can be added to the tooth surface and trabecular space. Adhesion and deposition can also be effectively prevented.

Hereinafter, the present invention will be described in detail.
The oral composition of the present invention contains phytic acid or a salt thereof as the component (A). Phytic acid, also known as myo-inositol 6-phosphate, is a phosphoric acid compound. By containing such a component (A), the deposited dirt existing in the trabecular space can be selectively and effectively removed, so that it is possible to effectively prevent excessive damage to the enamel. It is possible to suppress the appearance of harmful effects on the tooth surface and impart excellent gloss to the teeth.
Examples of the salt of phytic acid include alkali metal salts such as sodium and potassium, ammonium salts and the like.

The content of the component (A) is preferably 0.1% by mass or more in terms of acid in the oral composition of the present invention from the viewpoint of satisfactorily exerting the effect of removing deposited stains in the trabecular space. , More preferably 0.2% by mass or more, still more preferably 0.25% by mass or more, and even more preferably 0.3% by mass or more. In addition, the content of the component (A) further effectively enhances the effect of removing deposited stains on the tooth surface and the interstices, and its selectivity, suppresses the appearance of harmful effects on the tooth surface, and has excellent glossiness of the tooth. From the viewpoint of sustaining the above, the amount of acid in the oral composition of the present invention is preferably 2% by mass or less, more preferably 1.5% by mass or less, still more preferably 1% by mass or less. Yes, more preferably 0.9% by mass or less, even more preferably 0.8% by mass or less, and even more preferably 0.45% by mass or less. The content of the component (A) in the oral composition of the present invention is preferably 0.1% by mass or more and 2% by mass or less, more preferably 0.2% by mass or more in terms of acid. It is 1.5% by mass or less, more preferably 0.2% by mass or more and 1% by mass or less, still more preferably 0.25 to 0.9% by mass, and even more preferably 0.3 to 0%. It is 8.8% by mass, more preferably 0.3 to 0.45% by mass.
The "content of the component (A)" is the value of the "acid conversion amount" as described above, regardless of the type of salt form thereof.

The oral composition of the present invention contains tripolyphosphate or a salt thereof as the component (B). By containing such a component (B), the tooth surface is satisfactorily coated while ensuring the effect of removing the deposited stains in the trabecular meshwork in combination with the component (A), and the deposited stains are again formed on the tooth surface and the trabecular meshwork. Since it can be effectively prevented from adhering, it is possible to maintain the excellent luster of the teeth.
Examples of the salt of the component (B) include alkali metal salts such as sodium and potassium, and sodium is preferable.

The content of the component (B) is preferably 0.1% by mass in terms of acid in the oral composition of the present invention from the viewpoint of satisfactorily exerting the effect of preventing the adhesion of deposited stains on the tooth surface and the interstices. % Or more, more preferably 0.15% by mass or more, still more preferably 0.2% by mass or more, still more preferably 0.25% by mass or more, still more preferably 0.3% by mass. % Or more. In addition, the content of the component (B) further effectively enhances the effect of removing deposited stains on the tooth surface and the interstices, and its selectivity, suppresses the appearance of harmful effects on the tooth surface, and has excellent glossiness of the tooth. From the viewpoint of sustaining the above, the amount of acid in the oral composition of the present invention is preferably 1% by mass or less, more preferably 0.9% by mass or less, still more preferably 0.8% by mass. It is less than or equal to, and more preferably 0.7% by mass or less. The content of the component (B) is preferably 0.1 to 1% by mass, more preferably 0.15 to 0.9% by mass in terms of acid in the oral composition of the present invention. It is even more preferably 0.2 to 0.8% by mass, even more preferably 0.25 to 0.7% by mass, and even more preferably 0.3 to 0.7% by mass. be.
The "content of the component (B)" is the value of the "acid conversion amount" as described above, regardless of the type of salt form thereof.

The mass ratio ((B) / (A)) of the content of the component (B) to the content of the component (A) was excellent in the dirt removing effect in the trabecular meshwork and excellent in the tooth surface and the trabecular meshwork. From the viewpoint of effectively combining the effect of preventing the adhesion of deposited stains, it is preferably 0.1 or more, more preferably 0.4 or more, more preferably 0.5 or more, still more preferably 0.7 or more. Yes, more preferably 0.8 or more, even more preferably 1.1 or more, even more preferably 1.2 or more, still more preferably 1.4 or more, still more preferably 1.55. That is all. Further, the mass ratio ((B) / (A)) of the content of the component (B) to the content of the component (A) further enhances the effect of removing the deposited stain on the tooth surface and the interstitial space and its selectivity. From the viewpoint of effectively enhancing, suppressing the development of harmful effects on the tooth surface, effectively preventing the elution of tooth enamel and the development of squeaky feeling, and effectively maintaining the smooth luster of the tooth, it is preferable. It is 5 or less, more preferably 4 or less, and even more preferably 3 or less. The mass ratio ((B) / (A)) of the content of the component (B) to the content of the component (A) is preferably 0.1 to 5, more preferably 0.4 to 4. It is more preferably 0.5 to 4, still more preferably 0.7 to 3, even more preferably 0.8 to 3, and even more preferably 1.1 to 3. It is more preferably 1.2 to 3, still more preferably 1.4 to 3, and even more preferably 1.5 to 3.

The sum of the content of the component (A) and the content of the component (B) ((A) + (B)) is the effect of removing stains on the columnar gap and the effect of preventing the adhesion of deposited stains on the tooth surface and the columnar gap. Is preferably 0.3% by mass or more, more preferably 0.45% by mass or more, and more preferably 0.55% by mass or more in the oral composition of the present invention from the viewpoint of effectively exerting. It is more preferably 0.6% by mass or more, further preferably 0.65% by mass or more, and further preferably 0.75% by mass or more. Further, the sum of the content of the component (A) and the content of the component (B) ((A) + (B)) is more effective in removing the deposited stains on the tooth surface and the interstitial space and its selectivity. In the oral composition of the present invention, it is preferably 2% by mass or less, more preferably. Is 1.2% by mass or less, more preferably 1.1% by mass or less, still more preferably 1% by mass or less. The total of the content of the component (A) and the content of the component (B) ((A) + (B)) is preferably 0.3 to 2% by mass in the oral composition of the present invention. It is more preferably 0.45 to 2% by mass, more preferably 0.55 to 1.2% by mass, still more preferably 0.6 to 1.1% by mass, and even more preferably. It is 0.6 to 1% by mass, more preferably 0.65 to 1% by mass, and even more preferably 0.75 to 1% by mass.

The oral composition of the present invention contains glycerin in an amount of 8% by mass or more and 40% by mass or less as the component (C). As a result, even when the pH of the composition is in the high range, the effect of removing the deposited stains in the trabecular meshwork combined with the component (B) by the component (A) is effectively exhibited, and the selectivity thereof is further effectively enhanced. be able to.

The content of the component (C) is 8% by mass or more in the oral composition of the present invention from the viewpoint of further effectively enhancing the effect of removing deposited stains on the tooth surface and the trabecular space and its selectivity. , It is preferably 11% by mass or more, more preferably 12% by mass or more, and further preferably 13% by mass or more. Further, the content of the component (C) is 40% by mass or less, preferably 35% by mass or less, more preferably 35% by mass or less in the oral composition of the present invention from the viewpoint of ensuring a good usability. Is 28% by mass or less, more preferably 25% by mass or less, still more preferably 20% by mass or less. The content of the component (C) in the oral composition of the present invention is 8% by mass or more and 40% by mass or less, preferably 11 to 35% by mass, and more preferably 12 to 28% by mass. %, More preferably 13 to 25% by mass, and even more preferably 13 to 20% by mass.

The mass ratio ((C) / (B)) of the content of the component (C) to the content of the component (B) is effective in removing stains in the trabecular space even when the pH of the composition is high. It is 25 or more, preferably 30 or more, and more preferably 35 or more, from the viewpoint of exerting the effect. Further, the mass ratio ((C) / (B)) of the content of the component (C) to the content of the component (B) further enhances the effect of removing deposited stains on the tooth surface and the interstitial space and its selectivity. From the viewpoint of effectively enhancing, suppressing the onset of harmful effects on the tooth surface, and effectively maintaining the smooth luster of the tooth, it is 80 or less, preferably 75 or less, and more preferably 65 or less. .. The mass ratio ((C) / (B)) of the content of the component (C) to the content of the component (B) is 25 or more and 80 or less, preferably 30 to 75, more preferably. Is 35-65.

The mass ratio ({(A) + (B)} / (C)) of the content of the component (A) and the total content of the component (B) to the content of the component (C) is the component (A). , (B) and (C) are 0.025 or more, preferably 0.028 or more, from the viewpoint of further effectively enhancing the effect of removing deposited stains on the tooth surface and the space between trabeculae and its selectivity. It is more preferably 0.03 or more, further preferably 0.035 or more, still more preferably 0.04 or more. Further, the mass ratio ({(A) + (B)} / (C)) of the content of the component (A) and the total content of the component (B) to the content of the component (C) is good. From the viewpoint of ensuring a feeling of use, it is 0.08 or less, preferably 0.07 or less, more preferably 0.06 or less, and further preferably 0.045 or less. The mass ratio ({(A) + (B)} / (C)) of the content of the component (A) and the total content of the component (B) to the content of the component (C) is 0. It is 025 or more and 0.08 or less, preferably 0.028 to 0.07, more preferably 0.03 to 0.06, still more preferably 0.035 to 0.045, and further. It is preferably 0.04 to 0.045.

The mass ratio ((A) / (C)) of the content of the component (A) to the content of the component (C) further makes the effect of removing deposited stains on the tooth surface and the interstitial space and its selectivity more effective. It is preferably 0.003 or more, more preferably 0.005 or more, still more preferably 0.005 or more, from the viewpoint of enhancing, suppressing the development of harmful effects on the tooth surface, and effectively maintaining the smooth luster of the tooth. It is 0.01 or more, more preferably 0.015 or more. Further, the mass ratio ((A) / (C)) of the content of the component (A) to the content of the component (C) is the effect of removing stains in the interstitial space even when the pH of the composition is high. It is preferably 0.05 or less from the viewpoint of effectively exerting the above-mentioned effect, further effectively enhancing the selectivity of the deposit stain removing effect on the tooth surface and the interstitial space, and suppressing the occurrence of harmful effects on the tooth surface. It is more preferably 0.04 or less, still more preferably 0.025 or less. The mass ratio ((A) / (C)) of the content of the component (A) to the content of the component (C) is preferably 0.003 to 0.05, more preferably 0.005. It is ~ 0.04, more preferably 0.01 to 0.025, still more preferably 0.015 to 0.025.

The oral composition of the present invention is restricted from containing one or more polyvalent metals selected from copper, iron, calcium, magnesium, aluminum, zinc, and tin, or a salt (D) thereof. Since these components (D) may make the component (A) insoluble or reduce the excellent dirt removing effect in the trabecular meshwork, the smooth glossiness of the teeth and their sustainability are effectively ensured. From the top, it also limits its content. The oral composition of the present invention contains these components (D) in an amount of less than 0.1 times by mole, preferably 0.02 times by mole or less, or the component (D). Does not contain.
The content of the component (D) is a value measured as the total amount of polyvalent cations of the component (D) by an ICP emission spectrometry method (ICP emission spectrometer: Optima 5300DV manufactured by PerkinElmer).

The oral composition of the present invention contains monofluorophosphate or an alkali metal salt (E) thereof from the viewpoint of enhancing the effect of removing deposited stains and its selectivity and effectively increasing the amount of fluorine adsorbed on teeth. be able to.
Examples of the alkali metal of the alkali metal salt of the component (E) include sodium and potassium, and sodium is preferable. The content of the component (E) in the oral composition of the present invention is preferably 0.08 to 1.5% by mass, more preferably 0.4 to 1.2% by mass, and further. It is preferably 0.6 to 0.85% by mass.

The oral composition of the present invention is a sugar alcohol (from the viewpoint of more effectively providing the action of the component (C) that greatly contributes to the effect of removing the deposited stains in the trabecular meshwork and its selectivity more effectively. It is preferable to contain G). Specific examples of such component (G) include one or more selected from erythritol, sorbitol, reduced palatinol, and mannitol. Of these, sorbitol and erythritol are preferable, and erythritol is particularly preferable, from the viewpoint of sufficiently exerting a synergistic effect with the component (C).

The content of the component (G) is preferably 5% by mass or more, more preferably 10 in the oral composition of the present invention, from the viewpoint of enhancing the effect of removing deposited stains in the trabecular meshwork and its selectivity. It is mass% or more, and more preferably 15 mass% or more. The content of the component (G) is preferably 60% by mass or less, more preferably 55% by mass or less, and further preferably 55% by mass or less in the oral composition of the present invention from the viewpoint of storage stability of the preparation. It is preferably 50% by mass or less. The content of the component (G) is preferably 5 to 60% by mass, more preferably 10 to 55% by mass, and further preferably 15 to 50% by mass in the oral composition of the present invention. Is.

The mass ratio ((C) / (G)) of the content of the component (C) to the content of the component (G) is from the viewpoint of effectively enhancing the effect of removing deposited stains in the trabecular space and its selectivity. It is preferably 0.15 or more, more preferably 0.2 or more, still more preferably 0.3 or more, preferably 40 or less, more preferably 15 or less, still more preferably 8 or less. It is more preferably 6 or less, still more preferably 3 or less. The mass ratio ((C) / (G)) of the content of the component (C) to the content of the component (G) is preferably 0.15 to 40, more preferably 0.2 to 15. It is more preferably 0.3 to 8, still more preferably 0.3 to 6, and even more preferably 0.3 to 3.

Among them, when the component (G) is erythritol, the mass ratio ((C) / erythritol) of the content of the component (C) to the content of erythritol is preferably 0.13 or more, more preferably 0. .15 or more, more preferably 0.2 or more, more preferably 0.3 or more, still more preferably 0.35 or more, preferably 8 or less, more preferably 7 or less. , More preferably 6 or less, still more preferably 5 or less. The mass ratio ((C) / erythritol) of the content of the component (C) to the content of erythritol is preferably 0.13 to 8, more preferably 0.15 to 7, and even more preferably 0.15 to 7. Is 0.2 to 6, more preferably 0.3 to 5, and even more preferably 0.35 to 5.

The mass ratio ({(A) + (B)} / (G)) of the content of the component (A) and the total content of the component (B) to the content of the component (G) is in the trabecular space. From the viewpoint of effectively combining an excellent dirt removing effect and an excellent deposit dirt adhering prevention effect on the tooth surface and the interstitial space, the amount is preferably 0.01 or more, preferably 0.013 or more, and more preferably 0.013 or more. It is 0.014 or more, more preferably 0.015 or more, further preferably 0.017 or more, preferably 0.2 or less, more preferably 0.18 or less, still more preferably 0. It is .15 or less. Then, the mass ratio ({(A) + (B)} / (G)) of the content of the component (A) and the total content of the component (B) to the content of the component (G) is preferable. It is 0.01 to 0.2, preferably 0.013 to 0.2, more preferably 0.014 to 0.18, still more preferably 0.015 to 0.15, still more preferably. Is 0.017 to 0.15.

Among them, when the component (G) is erythritol, the mass ratio of the total content of the component (A) and the content of the component (B) to the content of erythritol ({(A) + (B)} / erythritol) ) Is preferably 0.01 or more, preferably 0.013, from the viewpoint of effectively combining the excellent dirt removing effect in the column gap and the excellent dirt adhering prevention effect in the tooth surface and the column gap. It is more preferably 0.014 or more, further preferably 0.015 or more, further preferably 0.016 or more, further preferably 0.018 or more, and preferably 0.15 or less. It is more preferably 0.14 or less, still more preferably 0.13 or less. The mass ratio ({(A) + (B)} / erythritol) of the content of the component (A) and the total content of the component (B) to the content of erythritol is preferably 0.01 to 0. It is .15, preferably 0.013 to 0.15, more preferably 0.014 to 0.14, still more preferably 0.015 to 0.13, still more preferably 0.016 to 0.13. It is 0.13, more preferably 0.018 to 0.13.

When the oral composition of the present invention is a dentifrice composition such as a dentifrice or a powdered dentifrice, the composition is retained and diffused in the vicinity of the tooth surface while having an appropriate viscosity to remove stains in the interstitial space. It contains a cellulose-based binder (H) from the viewpoint of effectively and efficiently exerting the effect and the effect of preventing the adhesion of deposited stains on the tooth surface and the interstices, and from the viewpoint of maintaining the smooth glossiness of the tooth. Is preferable. Specific examples of the cellulosic binder (H) include one or more selected from carboxymethyl cellulose or a salt thereof, and hydroxyalkyl cellulose such as hydroxyethyl cellulose and hydroxypropyl cellulose, and carboxy Methyl cellulose or a salt thereof is preferable.

As the carboxymethyl cellulose or a salt thereof, carboxymethyl cellulose having a degree of etherification of 0.95 to 1.5 or a salt thereof is preferable. The degree of etherification of the carboxymethyl cellulose or a salt thereof is preferably 0.95 or more, more preferably 1.0 or more, from the viewpoint of imparting an appropriate viscosity and retaining and diffusing the composition in the vicinity of the tooth surface. It is preferably 1.5 or less, and more preferably 1.15 or less. Further, the degree of etherification of the carboxymethyl cellulose or a salt thereof is preferably 0.95 to 1.5, more preferably 0.95 to 1.5, from the viewpoint of imparting an appropriate viscosity and retaining and diffusing the composition in the vicinity of the tooth surface. Is 1.0 to 1.15.

The degree of etherification of carboxymethyl cellulose or a salt thereof means the degree of substitution of carboxymethyl groups per glucose unit. The degree of etherification can be obtained according to, for example, the CMC industry association analysis method (ashing method). 1 g of carboxymethyl cellulose or a salt thereof is precisely weighed, placed in a magnetic rut and incinerated at 600 ° C., and sodium oxide produced by the incineration is titrated with N / 10 sulfuric acid using phenolphthalein as an indicator, and 1 g of carboxymethyl cellulose or a salt thereof is titrated. The titration amount YmL per titration can be calculated by putting it in the following formula, and the obtained degree of etherification can be shown.
Degree of etherification = (162 × Y) / (10,000-80 × Y)
Examples of the salt of carboxymethyl cellulose include alkali metal salts such as sodium and potassium, ammonium salts and the like, and among them, sodium carboxymethyl cellulose is preferable.

The content of the cellulosic binder (H) causes the composition to stay and diffuse in the vicinity of the tooth surface while having an appropriate viscosity, and has a stain removing effect on the tooth surface and a deposit stain on the tooth surface and the column gap. From the viewpoint of effectively and efficiently exerting the anti-adhesion effect, it is preferably 0.2% by mass or more, more preferably 0.4% by mass or more, and further preferably 0.4% by mass or more in the oral composition of the present invention. Is 0.6% by mass or more, preferably 2% by mass or less, more preferably 1.8% by mass or less, and further preferably 1.6% by mass or less. The content of the cellulosic binder (H) in the oral composition of the present invention is preferably 0.2 to 2% by mass, more preferably 0.4 to 1.8% by mass. Yes, more preferably 0.6 to 1.6% by mass.

When the oral composition of the present invention is a dentifrice composition such as a dentifrice or a dentifrice powder, the composition is retained and diffused in the vicinity of the tooth surface while having an appropriate viscosity to remove stains in the interstitial space. From the viewpoint of effectively and efficiently exerting the effect and the effect of preventing the adhesion of deposited stains on the tooth surface and the interstitial space between the pillars, the viscous silica (I) having an oil absorption amount of 200 mL / 100 g or more and 400 mL / 100 g or less together with the component (H). ) Is preferably contained. That is, the thickening silica of the component (I) is silica having a large amount of oil absorption, and is different from silica used as an abrasive. Here, the oil absorption amount indicates the amount of oil that silica can support, and the measurement method is specified by the amount of oil absorbed in the boiled sardine by the method of JIS K5101-13-2 (established in 2004). Means the value to be. Commercially available thickening silicas include silicia, silopure (manufactured by Fuji Silysia Chemical Ltd.), thixosyl (manufactured by Rhodia), sobosil (manufactured by Ineos silica), fine seal (manufactured by Tokuyama), and nipgel (manufactured by Tosoh silica). Goods can be used. The oil absorption of the component (I) is preferably 220 to 380 mL / 100 g, and more preferably 230 to 350 mL / 100 g.

The content of the component (I), in combination with the component (H), gives an appropriate viscosity to the composition, and the composition stays and diffuses in the vicinity of the tooth surface to remove stains in the trabecular space and to remove teeth. From the viewpoint of effectively exerting both the effect of preventing the adhesion of deposited stains on the surface and the interstices, the content of the oral composition of the present invention is preferably 1% by mass or more, more preferably 3% by mass or more. It is more preferably 5% by mass or more, preferably 15% by mass or less, more preferably 12% by mass or less, still more preferably 9% by mass or less. The content of the component (I) in the toothpaste composition of the present invention is preferably 1% by mass or more and 15% by mass or less, and more preferably 3 to 12% by mass in the oral composition of the present invention. Is.

From the viewpoint of effectively and efficiently exerting the effects of the present invention, the oral composition of the present invention contains an alkyl sulfate such as sodium lauryl sulfate, an acylmethyl taurine salt, an N-acyl fatty acid salt, and an alkyl phosphorus as a foaming agent. One or more anionic surfactants selected from acid salts, higher fatty acid sulfonated monoglycerides, fatty acid ester salts, polyoxyalkyl phosphates, alkylbenzene sulfonates, alkyl sulfoacetates and α-olefin sulfonates. It is preferable to contain an agent. Of these, sodium lauryl sulfate is preferable.

When the oral composition of the present invention is a liquid oral composition such as a mouthwash or a liquid dentifrice, the content of the anionic surfactant is preferably 0.5 in the oral composition of the present invention. It is ~ 5% by mass, more preferably 1 to 3% by mass. When the oral composition of the present invention is a dentifrice composition such as a dentifrice or a powdered dentifrice, the content of the anionic surfactant is preferably 0.2 in the oral composition of the present invention. It is ~ 5% by mass, 0.5 to 5% by mass, and more preferably 1 to 3% by mass.

The oral composition of the present invention contains water (F). The water of the component (F) in the present invention is contained not only in purified water or the like blended in the oral composition, but also in each blended component such as a 70% sorbitol solution (aqueous solution) used at the time of formulation. It means the total water contained in the oral composition, including water. By containing the water of the component (F), each component is well dispersed or dissolved and diffused well in the oral cavity while maintaining good shape retention, and excellent deposition stain removal in the trabecular space is removed. It is possible to exert the effect and a high effect of preventing the adhesion of deposited stains on the tooth surface and the trabecular space. Usually, the content of the component (F) is preferably 5 to 99% by mass, more preferably 6 to 95% by mass, still more preferably 7 to 90% by mass in the oral composition of the present invention. It is more preferably 8 to 50% by mass, further preferably 9 to 40% by mass, and further preferably 10 to 33% by mass.

When the oral composition of the present invention is a dentifrice composition such as a dentifrice or a powdered dentifrice, the water content thereof can be calculated by calculation from the water content in the blended water content and the water content in the blended ingredients. For example, it can be measured with a Karl Fischer titer. As the Karl Fischer titer, for example, a trace moisture measuring device (Hiranuma Sangyo Co., Ltd.) can be used. In this device, 5 g of the toothpaste composition is taken, suspended in 25 g of anhydrous methanol, and 0.02 g of this suspension can be separated to measure the water content.

In addition to the above components, the oral composition of the present invention contains a wetting agent such as polyethylene glycol and propylene glycol; a pH adjuster; a surfactant other than the anionic surfactant; Fluoride; bactericide; preservative; fragrance; pigment; abrasive; granules and the like can be contained.

The oral composition of the present invention effectively exerts the effect of removing deposited stains in the trabecular meshwork by the components (A), (B) and (C), and from the viewpoint of sufficiently ensuring the effect of further enhancing the selectivity thereof. , The pH at 25 ° C. is more than 6.5, preferably 6.7 or more, more preferably 6.8 or more, preferably 10.5 or less, more preferably 10 or less. More preferably, it is 9 or less.
In the case of a dentifrice composition such as a dentifrice or a powdered dentifrice, the pH of the oral composition of the present invention is obtained by diluting the composition with water to 30% by mass. The pH of. The assumption that the toothpaste composition is diluted to 30% by mass with water is assumed to be a state in which the toothpaste composition is applied into the oral cavity and diluted with saliva or the like. The water used is purified water, which is distilled water or ion-exchanged water.

The viscosity of the oral composition of the present invention at 25 ° C. allows the composition to stay and diffuse in the vicinity of the tooth surface while having an appropriate viscosity or viscosity, and has an effect of removing deposited stains in the interstitial space and the tooth surface and the columnar. From the viewpoint of effectively and efficiently exerting the effect of preventing the adhesion of deposited stains in the gaps, it is preferably 1500 dPa · s or more, more preferably 1800 dPa · s or more, preferably 4000 dPa · s or less, and more preferably. It is 3500 dPa · s or less. The viscosity of the oral composition of the present invention at 25 ° C. is preferably 1500 to 4000 dPa · s, and more preferably 1800 to 3500 dPa · s.
Here, the viscosity is measured using a helipas type viscometer (VISCOMETER TVB-10 Toki Sangyo) at a measurement temperature of 25 ° C. and a rotor TC, a rotation speed of 2.5 r / min, and measurement conditions for 1 minute. be able to.

Examples of the form of the oral composition of the present invention include a liquid oral composition such as a mouthwash and a liquid dentifrice, and a dentifrice composition such as a dentifrice and a dentifrice powder. Mouthwash from the viewpoint of more effectively exerting the stain removing effect and the effect of preventing the adhesion of deposited stains on the tooth surface and the interstices, making the selectivity excellent, and continuously imparting a beautiful luster to the teeth. It is preferably a liquid oral composition such as a liquid dentifrice or a liquid dentifrice.

Hereinafter, the present invention will be specifically described based on examples. Unless otherwise specified in the table, the content of each component indicates mass%.

[Examples 1 to 8, Comparative Examples 1 to 4]
According to the formulations shown in Tables 1 to 4, a liquid oral composition having a component (D) of less than 0.1 times by mole was prepared. Using each of the obtained liquid oral compositions, each measurement and evaluation was performed according to the following method.
The results are shown in Tables 1-4.

<< Measurement of calcium elution amount of low crystalline HAp (evaluation of deposition stain removal effect in trabecular meshwork) >>
Take 1 g of hydroxyapatite (HAp) powder (HAP-100, manufactured by Taihei Kagaku Sangyo Co., Ltd.), which is a low crystalline HAp, in a styrene rod bottle (capacity 120 mL), and further add each composition shown in Table 1 to 4 with purified water. 50 mL of the double-diluted solution was added, and the slurry solution was stirred for 15 minutes. After stirring, 1 mL of the solution was filtered through a 0.45 μm filter.
Next, using Calcium E-Test Wako (manufactured by Wako Pure Chemical Industries, Ltd.), the eluted calcium ions were measured to determine the amount of calcium eluted (ppm) in the low crystalline HAp, and the stain removal effect in the trabecular space was evaluated. It was used as an index of.
The larger the elution amount value, the better the dirt removing effect in the trabecular space.

《Measurement of calcium elution of highly crystalline HAp (suppression of harmful effects on tooth surface)》
Low crystalline HAp except that HAP-200 (manufactured by Taihei Kagaku Sangyo Co., Ltd.), which is a highly crystalline HAp, was used instead of HAP-100 (manufactured by Taihei Kagaku Sangyo Co., Ltd.) as the hydroxyapatite (HAp) powder. The amount of calcium elution (ppm) in the highly crystalline HAp was measured in the same manner as the evaluation of the elution property of the above, and used as an index for the evaluation of the selectivity of the stain removing effect in the trabecular space.
The smaller the elution amount value, the higher the selectivity of the deposit stain removing effect in the trabecular meshwork, and the more excellent the suppression of the occurrence of harmful effects on the tooth surface.

<< Calculation of difference in calcium elution amount (calculation of selectivity of deposition stain removal effect in trabecular meshwork) >>
From the above-mentioned "calcium elution amount of low crystalline HAp", which means that the larger the elution amount value is, the better the stain removal effect in the trabecular space is, the smaller the elution amount value is, the more the deposit stain removal effect is selected in the trabecular space. The "calcium elution amount difference" is calculated by subtracting the "calcium elution amount of highly crystalline HAp", which means that it has high properties and is excellent in suppressing the onset of harmful effects on the tooth surface, and the effect of removing deposited stains in the trabecular space. The selectivity of calcium was used as an index for more accurate evaluation.
The larger the value of the difference in the amount of elution, the more excellent the selectivity of the effect of removing the deposited dirt in the trabecular space.

As the oral composition of the present invention, a dentifrice having the formulation shown in Table 5 below can be prepared. The viscosity at 25 ° C. was 2500 dPa · s.

From the above results, in the oral composition of the present invention, since the value of the calcium elution amount of low crystalline HAp is large, the effect of removing stains in the interstitial space is excellent, and the value of the calcium elution amount of high crystalline HAp. Is small, so that the effect of removing deposited stains in the interstitial space and its selectivity are high, and it is excellent in suppressing the occurrence of harmful effects on the tooth surface. That is, since the value of the calcium elution amount of these low crystalline HAp is large and the value of the elution amount difference between the calcium elution amount of low crystalline HAp and the calcium elution amount of high crystalline HAp is large, as a result, the columnar column It can be seen that the effect of removing deposited stains in the gap and its selectivity are further excellent.
From the above, the oral composition of the present invention is effective in coating the tooth surface well and reattaching the deposited stains to the tooth surface and the trabecular space while ensuring the effect of removing the deposited stains in the trabecular space. It can be seen that it can be prevented.

Claims (6)

The following components (A) to (C):
(A) Phytic acid or a salt thereof (B) Tripolyphosphate or a salt thereof (C) Glycerin Contains 8% by mass or more and 40% by mass or less.
The mass ratio ((C) / (B)) of the content of the component (C) to the content of the component (B) is 25 or more and 80 or less.
The mass ratio ({(A) + (B)} / (C)) of the content of the component (A) and the total content of the component (B) to the content of the component (C) is 0.025 or more and 0. .08 or less,
Contains neither copper, iron, calcium, magnesium, aluminum, zinc, and tin polyvalent metals or salts thereof , or copper, iron, calcium, magnesium, aluminum, zinc relative to the content of component (A) An oral composition containing less than 0.1 times by molar of one or more polyvalent metals or salts (D) thereof selected from, and tin, and having a pH of more than 6.5 at 25 ° C. The oral composition according to claim 1, wherein the mass ratio ((B) / (A)) of the content of the component (B) to the content of the component (A) is 0.1 or more and 5 or less. The oral composition according to claim 1 or 2, further containing monofluorophosphate or an alkali metal salt (E) thereof. The oral composition according to any one of claims 1 to 3, wherein the content of water (F) is 5% by mass or more and 99% by mass or less. The oral composition according to any one of claims 1 to 4, wherein the content of the component (A) and the total content of the component (B) are 0.3% by mass or more and 2% by mass or less. The oral composition according to any one of claims 1 to 5, wherein the viscosity at 25 ° C. is 1500 dPa · s or more and 4000 dPa · s or less.