JP6961569B2 - Hydration agent - Google Patents

Description

Reference of related application

The patent application of the present application is accompanied by a priority claim based on Japanese application Japanese Patent Application No. 2016-32320 filed on February 23, 2016, and the entire disclosure contents of this Japanese application are by reference to the invention of the present application. Is part of the disclosure of.

The present invention relates to a hydration agent containing milk protein, sodium, sugar, and a stabilizer as active ingredients and which is acidic.

Dehydration and heat stroke are likely to occur not only when exercising or working in the hot sun, but also in a hot and humid environment, even in daily activities indoors such as sleeping. In particular, elderly people who tend to decrease the amount of body fluid (total amount of water in the body including water and electrolytes) and the amount of food that is important for water intake, and children (0 to 15 years old) who are susceptible to temperature. In), it is difficult to notice that dehydration is occurring, and the so-called heat stroke from dehydration, which is gradually becoming dehydrated, has become a serious problem.

In order to prevent heat stroke, it is necessary to efficiently release (heat heat) the heat generated by exercise, work, daily activities, etc. to the outside of the body to regulate the body temperature. Then, this heat dissipation is accompanied by an increase in the blood flow rate of the skin for the purpose of heat dissipation by heat conduction to the outside air, and an increase in the amount of perspiration for the purpose of heat dissipation by evaporation of sweat. Therefore, in order to prevent heat stroke (prevention and alleviation), it is necessary to promptly replenish and retain water in the body.

Milk has an excellent ability to retain the ingested water, but since casein, which is a component of milk, solidifies in the stomach, it is slower to excrete in the stomach and absorb more water into the body than water and sports drinks. There was a problem with.

On the other hand, sports drinks containing sugars and electrolytes are often used for the purpose of supplementing sugars consumed by exercise and electrolytes lost by sweating, and effectiveness regarding hydration has been reported so far (for example). , Non-Patent Documents 1 and 2). However, it has been reported that these sports drinks are not always sufficient from the viewpoint of retaining water for a long time in the body and are inferior to milk (see, for example, Non-Patent Document 3).

Oral Rehydration Solution (ORS) is a beverage developed to treat dehydration in cholera, which causes diarrhea that loses large amounts of sodium. Many beverages contain a large amount of sodium and are adjusted to be hypotonic, which has a lower osmotic pressure than body fluids. However, when oral rehydration solutions designed for the treatment of pathological dehydration with vomiting and diarrhea are used for hydration in exercise, work and daily activities in healthy individuals, in some cases hypernatremia. May induce hypertension in the long run.

Patent Document 1 discloses a plasma volume increasing accelerator containing a gel-like composition as an active ingredient, but the gel-like composition contains calcium and is completely different from the food and drink of the present invention. It is a thing.

Patent Document 2 discloses an acidic protein composition containing a protein derived from an aqueous protein isolate, but the food or drink of the present invention is in that the composition does not essentially contain caseinate. Is completely different.

Japanese Unexamined Patent Publication No. 2004-137268 Special Table 2014-509525

Chang, C.Q et al., “Effects of a carbohydrate-electrolyte beverage on blood modulus after dehydration in healthy adults,” Chin. Med. J., 2010, 123 (22), 3220-3225 Shirreffs, S.M et al., “Rehydration after exercise in the heat: a comparison of 4 commonly used drinks,” Int. J. Sport Nutr. Exerc. Metab., 2007, 17, 244-258. Shirreffs, S.M et al., “Milk as an effective post-exercise rehydration drink,” Br. J. Nutr., 2007, 98, 173-180.

An object of the present invention is to provide a hydration agent having a property of rapidly absorbing water into a living body.

The present inventors have found that when a mixture containing milk protein, sodium, sugar, and a stabilizer as an active ingredient and made acidic is ingested together with water, water is promptly taken into the living body, and this water content. Developed a supplement. It was also unexpectedly found that this hydration agent is not excreted as urine even after a long period of time, and can retain water in the body for a long time. The present invention is based on these findings.

According to the present invention, the following inventions are provided.
[1] A hydrating agent containing milk protein, sodium, sugar, and a stabilizer as active ingredients and being acidic.
[2] The hydration agent according to (1), which is used for maintaining hydration.
[3] The hydration agent according to (1) or (2), wherein the milk protein concentration is 2 to 7% by weight.
[4] The hydration agent according to any one of (1) to (3), wherein the sodium concentration is 0.005 to 0.1% by weight.
[5] The hydration agent according to any one of (1) to (4), wherein the sugar concentration is 0.1 to 10% by weight.
[6] The hydration according to any one of (1) to (5), wherein the sugar contains at least one selected from the group consisting of trehalose, sucrose, isomaltulose, maltose, lactose, glucose, and dextrin. Agent.
[7] Stabilizers are 0.2-1.2% by mass of soybean polysaccharide, 0.1-0.5% by mass of HM pectin, and 0.01-0.1% by mass of fibrous insoluble cellulose. The hydration agent according to any one of (1) to (6), which contains.
[8] The hydration agent according to any one of (1) to (7), wherein the pH of the hydration agent is 3 to 6.
[9] A milk food or drink for hydration that contains milk protein, sodium, sugar, and a stabilizer as active ingredients and is acidic.
[10] The milk food or drink for hydration according to (9), which is a milk beverage.
[11] Moisture, which comprises ingesting the hydration agent according to any one of (1) to (8) or the hydration milk food and drink according to (9) or (10). Replenishment method.
[12] For the manufacture of foods and drinks or pharmaceuticals for hydration, which contain milk protein, sodium, sugar and stabilizer as active ingredients and are acidic. Use for manufacturing.
[13] A food or drink or a drug containing milk protein, sodium, sugar, and a stabilizer as active ingredients for replenishing water and being acidic.
[14] Use of foods and drinks or pharmaceuticals containing milk protein, sodium, sugar, and stabilizer as active ingredients and being acidic for hydration.

According to the present invention, it is possible to provide a hydration agent having a property of rapidly absorbing water into a living body. Further, according to a preferred embodiment of the present invention, it is possible to provide a hydration retention agent having a property of rapidly absorbing water into a living body and retaining water in the living body for a long time.

FIG. 1 shows the rate of change in plasma volume (%) at each time point after oral administration of a beverage. FIG. 2 shows the cumulative urine excretion (mL) at each time point after oral administration of a beverage.

Specific description of the invention

The hydration agent of the present invention is an acidic hydration agent containing milk protein, sodium, sugar, and a stabilizer as active ingredients. Since the hydration agent of the present invention has a property of rapidly absorbing water into the living body, dehydration, heat stroke and the like can be promptly alleviated and prevented.

The hydration agent of the present invention includes not only those containing a predetermined amount of water described later, but also those containing an amount of water less than the predetermined amount of water and those in which the predetermined amount of water is substantially removed. do. Amount required when ingesting or administering a hydration agent of the present invention containing a water content less than a predetermined amount of water or a product in which a predetermined amount of water is substantially removed. Water is taken or administered simultaneously with or separately from the hydration agent.

The hydration agent of the present invention preferably contains a predetermined amount of water, which will be described later, from the viewpoint of convenience of ingestion or administration. Such a hydration agent is prepared as a mixture containing a predetermined amount of water so that a predetermined amount of water is simultaneously ingested or administered. That is, according to a preferred embodiment of the present invention, there is provided a hydration agent containing milk protein, sodium, sugar, stabilizer, and water as active ingredients and being acidic.

In the present invention, the "active ingredient" means an ingredient required for exerting a hydration effect and / or a hydration effect, and preferably hydrates and / or retains water in the body. It means an ingredient required to exert a hydration effect and / or a hydration effect for an object in a difficult environment and / or condition.

In the present invention, "a subject in an environment and / or a state in which it is difficult to replenish water and / or retain water in the body" means a body fluid, that is, a subject in which water and / or electrolytes in the body are likely to decrease. However, for example, a subject who performs continuous exercise such as strength training, outdoor work such as under the scorching sun, and indoor daily activities such as sleeping, particularly daily activities in a hot and humid environment can be mentioned. Dehydration is more likely to occur during continuous exercise, outdoor work or daily activities in a hot and humid environment. Therefore, the subjects for ingesting the hydration agent of the present invention include those who suffer from dehydration or heat stroke (such as those who are dehydrated) and those who suffer from dehydration or heat stroke.

The subject who ingests the hydration agent of the present invention is not particularly limited as long as it is a subject that requires hydration and / or retention of water in the body, but in the case of humans, specifically. Is a person who has lost or is expected to lose water corresponding to 1 to 9% by weight of the body weight of each subject. Here, if the weight loss due to water loss such as sweating is 1 to 2% by weight, it is classified as mild dehydration, if it is 3 to 9% by weight, it is classified as moderate dehydration, and if it is 10% by weight or more, it is classified as severe dehydration. .. The target also includes animals other than humans (livestock such as horses and cows, pet animals such as dogs and cats, and ornamental animals bred in zoos and the like).

The hydration agent of the present invention can promptly replenish hydration when ingested by a subject who needs to hydrate the body simultaneously or separately with a predetermined amount of hydration. Here, "immediately" can increase the plasma volume in the body within, for example, 60 minutes, preferably within 30 minutes, and more preferably within 15 minutes after ingesting water. Therefore, according to a preferred embodiment of the present invention, a water immediate (rapid) (for example, within 60 minutes) replenishing agent is provided.

In addition, the hydration agent of the present invention can retain water in the body for a long period of time when ingested by a subject who needs to retain water in the body simultaneously or separately with a predetermined amount of water. Here, the “long time” means a time during which a desired water retention effect is exhibited, although it appropriately varies depending on the environment and / or the state in which it is difficult to retain water in the body. Specifically, "long time" means, in normal daily activities, preferably 2 hours after ingestion, more preferably 3 hours after ingestion, still more preferably 4 hours after ingestion, and even more preferably after ingestion. It means that the body can retain the water to be ingested simultaneously or separately with the hydration agent of the present invention for 6 hours, more preferably 7 hours after ingestion, and particularly preferably 8 hours after ingestion. Therefore, according to a preferred embodiment of the present invention, a long-term hydration (for example, 2 hours or more) retention agent is provided.

The hydration effect (action, function) means that most of the water taken simultaneously with or separately from the hydration agent (or hydration retainer) of the present invention can be present in plasma in the body. Further, the hydration effect can be confirmed, for example, by a comparative test of plasma volume by rats. Specifically, the same amount of distillation as the water content of the test solution is distilled in the time after ingestion of the test solution and distilled water. If the plasma volume is high when the test solution is ingested as compared with the case where water is ingested, it can be judged to be significant (see, for example, Test Example 1 below). More specifically, the hydration effect can be confirmed from the plasma volume change rate (%).

The hydration effect (action, function) means that most of the water ingested simultaneously with or separately from the hydration agent (or hydration retainer) of the present invention can be retained in the body for a long time without being excreted as urine. Means. Further, the water retention effect can be confirmed, for example, by a comparative test of the amount of urine excreted in rats. Specifically, the amount of water in the test solution is the same as that in the time after ingestion of the test solution and distilled water. It can be judged that it is significant if the amount of urine excreted is small when the test solution is ingested as compared with the case where distilled water is ingested (see, for example, Test Example 2 below). Here, when distilled water is ingested, about 80% of the ingested amount is excreted as urine in about 2 hours after the ingestion. More specifically, the water retention effect can be confirmed from the water retention rate, and the water retention rate (%) is from Equation 1: [1- (urinary excretion / intake)] × 100. Can be calculated.

According to a preferred embodiment of the present invention, for example, in the hydration agent of the present invention, the plasma volume change rate (%) is, for example, 3% or more, preferably 5% or more, more than 15 minutes after ingestion. It is preferably 7% or more, more preferably 10% or more.

According to a preferred embodiment of the present invention, for example, in the hydration agent (or hydration retainer) of the present invention, the hydration retention rate is 65%, preferably 70%, more preferably 2 hours after ingestion. Is 80%, more preferably 85%, still more preferably 90%.

The hydration agent (or hydration retainer) of the present invention can retain water in the body for a long time. That is, since the hydration agent of the present invention has an excellent water retention effect, it is not necessary to take it many times in a short period of time if sufficient water can be ingested (administered) into the body. Therefore, the ingestion (administration) interval of ingesting (administering) the hydration agent of the present invention to a subject who needs to retain water in the body is set, for example, from the first ingestion of the hydration agent of the present invention. The interval between the next ingestion or the interval between the next ingestion and the next ingestion can be at least 0.5 hours. The intake interval is preferably at least 1 hour, more preferably at least 2 hours, still more preferably at least 3 hours, still more preferably at least 4 hours, still more preferably at least 5 hours, still more preferably at least 6 hours, and particularly preferably at least. It can be 7 hours, most preferably at least 8 hours. Further, the number of times the hydration agent of the present invention is ingested (administered) to a subject who needs to retain water in the body is not particularly limited, but sufficient water can be ingested (administered) in the body. That is, as long as it can be replenished, it may be taken once, that is, one breath (once). Here, the amount of water intake sufficient for the body varies depending on the environment and / or the condition in which it is difficult to retain water in the body, but in the case of humans, it is 50 to 1000 ml, preferably 100 to 1000 ml, and more preferably 150 to. It is 1000 ml, more preferably 200 to 1000 ml, and particularly preferably 250 to 1000 ml.

The method of ingesting (or administering) the hydration agent of the present invention simultaneously or separately with a predetermined amount of water is the subject and the subject from oral ingestion (or oral administration), enteral administration, gastric fistula, etc. It can be appropriately selected depending on the intended use, but is preferably oral ingestion (or oral administration).

The hydration agent of the present invention can prevent and alleviate dehydration, and thus prevent and alleviate heat stroke, by ingesting a predetermined amount of water at the same time or separately. That is, the hydration agent of the present invention can be used as a preventive (for) agent and / or a therapeutic (for) agent for dehydration or heat stroke.

The hydration agent of the present invention is preferably a hydration retention agent. The hydration-retaining (use) agent of the present invention has the characteristics of rapidly absorbing water into the living body and retaining water in the living body for a long time. Since the hydration retention agent of the present invention has such characteristics, dehydration and heat stroke can be promptly alleviated, and dehydration and heat stroke can be effectively prevented. It is advantageous in that it can be done.

The hydration agent and hydration retention agent of the present invention can be used to rehydrate or retain hydration before, during, and after exercise, when waking up, before going to bed, after taking a bath, after drinking alcohol, and on hot days. It is especially effective when doing so. In addition, the hydration agent and the hydration retention agent of the present invention are particularly intended not only for exercise subjects, but also for children who need hydration and retention, elderly people who need heat stroke countermeasures, and manual workers. It is useful.

In the present invention, "hydration" is based on the property of rapidly absorbing water into a living body, and may be another term as long as it means this. "Hydration agent" is, for example, "hydration promoting agent", "moisture absorption improving agent", "hydration rapid replenishing agent", "hydration improving agent", "blood volume increase promoting agent". , "Moisture increase promoting agent", "Plasma volume increase promoting agent", "Blood volume recovery promoting agent", "Moisture recovery promoting agent", or "Plasma volume recovery promoting agent" may be paraphrased. ..

In the present invention, "hydration retention" is based on the property that water is quickly absorbed into the living body and water is retained in the living body for a long time, and as long as this is meant, other terms are used. There may be. "Hydration retention agent" includes, for example, "hydration retention promotion agent", "moisture absorption retention improvement agent", "hydration retention improvement agent", "blood volume increase promotion retention agent", "moisture". It may be paraphrased as "recovery-promoting retention agent" or "plasma volume increase-promoting retention agent".

The pH of the hydration agent of the present invention is not particularly limited as long as it is acidic, but is preferably 3 to 6, more preferably 3 to 5, and even more preferably 3.5 to 4. It is 5. By setting the pH of the hydration agent of the present invention to 3 to 6, it is preferable that the acidity is appropriately felt and the hydration agent has a refreshing flavor with high palatability.

The milk protein contained in the hydration agent of the present invention is not particularly limited as long as it is a milk-derived protein, and for example, milk, sheep milk, goat milk, buffalo milk, sheep milk, camel milk, whale milk, and dolphins. It may be a milk protein of milk derived from a mammal such as milk or human milk. In addition, the milk protein contained in the hydration agent of the present invention contains, for example, whey protein, casein protein, whey proteolytic product, casein proteolytic product, peptide, or non-protein nitrogen component at a specific concentration (content). Some include. This "milk protein" is a mixture of separately separated and purified whey protein, casein protein, whey protein degradation product, casein protein degradation product, peptide, or non-proteinaceous nitrogen component to a specific concentration. It may already contain a specific concentration of whey protein, casein protein, whey protein degradation product, casein protein degradation product, peptide, or non-proteinaceous nitrogen component that has not been separated or purified separately. Raw materials (materials), foods and drinks, and the like may be used. At this time, the "milk protein" used in the present invention does not require a step of separating or purifying whey protein, casein protein, whey protein degradation product, casein protein degradation product, peptide, and non-protein nitrogen component, and these In terms of low manufacturing costs, the main products are whey protein, casein protein, whey protein degradation products, casein protein degradation products, or raw materials, foods and drinks that already contain peptide and non-protein nitrogen components at specific concentrations. As a component, if necessary, separately purified whey protein, casein protein, whey protein decomposition product, casein protein decomposition product, or peptide and non-proteinaceous nitrogen component may be mixed and used to a specific concentration. Is preferable.

As the milk protein contained in the hydration agent of the present invention, one kind of milk may be used alone, or two or more kinds of milk may be mixed and used. Then, this milk protein may use a high-purity component such as a chemical product (reagent or the like), or a mixed component such as a separated product or a purified product. Here, the protein content may be calculated based on known information such as a food composition table, or may be measured and calculated by a conventional method such as the Kjeldahl method or the Lowry method. In fact, in the case of the Kjeldahl method, nitrogen contained in various proteins can be measured and calculated by multiplying the value by a nitrogen-protein conversion coefficient (usually 6.25).

The milk protein contained in the hydration agent of the present invention may contain casein, and the milk protein containing casein refers to a milk protein composed of casein protein and whey protein. Here, the weight ratio of casein protein to whey protein in the hydration agent of the present invention is (casein protein) :( whey protein), for example, 20: 1, 15: 1, 12: 1, 10 1, 9: 1, 8: 1, 7: 1, 6: 1, 5: 1, 4: 1, 3: 1, 2: 1, 1: 1, 1: 2, 1: 3, 1: 4 , 1: 5, 1: 6, 1: 7, 1: 8, 1: 9, 1:10, 1:12, 1:15, 1:20. That is, the weight ratio of casein protein to whey protein in the hydration agent of the present invention is (casein protein) :( whey protein), for example, 20 to 1: 1 to 20, preferably 15 to 1: 1. ~ 15, more preferably 12 to 1: 1-12, still more preferably 10: 1 to 10, still more preferably 9 to 1: 1-9, still more preferably 8 to 1: 1-8, even more preferably. 7 to 1: 1 to 7, more preferably 6 to 1: 1 to 6, still more preferably 5 to 1: 1 to 5, still more preferably 4 to 1: 1 to 4, still more preferably 3 to 1: 1 to 3, more preferably 2 to 1: 1 to 2.

According to a preferred embodiment, the weight ratio of casein protein to whey protein in the milk protein contained in the hydration agent of the present invention is (casein protein) :( whey protein), for example, 5 to 3: 2. It may be ~ 0.5, preferably 4: 1.

The viscosity (10 ° C.) of the hydration agent of the present invention is, for example, 3 to 30 mPa · s, preferably 3.5 to 30 mPa · s, more preferably 4 to 30 mPa · s, still more preferably 4.5 to 30 mPa. S, more preferably 5 to 30 mPa · s, still more preferably 5.5 to 29 mPa · s, still more preferably 6 to 28 mPa · s, still more preferably 6.5 to 27 mPa · s, still more preferably 7 to 26 mPa · s. s, more preferably 7.5 to 25 mPa · s, still more preferably 8 to 24 mPa · s, still more preferably 8.5 to 23 mPa · s, still more preferably 9 to 22 mPa · s, still more preferably 9.5 to 21 mPa · s. · S, more preferably 10-20 mPa · s. This viscosity is the viscosity measured by a B-type rotational viscometer, and can be measured by using a general-purpose Brookfield viscometer or the like. When the viscosity (10 ° C.) of the hydration agent of the present invention exceeds 3 mPa · s and the casein protein is contained in the hydration agent of the present invention, the hydration agent due to the destabilization of the casein protein It is preferable because it can prevent separation and precipitation. Further, since the viscosity (10 ° C.) of the hydration agent of the present invention is less than 30 mPa · s, even a hydration agent containing a milk protein containing a high concentration of casein has a low viscosity and is easy to drink. It is preferable because it can prevent the protein from disappearing.

The concentration of the milk protein contained in the hydration agent of the present invention is not particularly limited as long as the effect of the present invention is exhibited, but is preferably 2 to 7% by weight, more preferably 3 to 5% by weight. be.

The concentration of sodium contained in the hydration agent of the present invention is not particularly limited as long as the effects of the present invention are exhibited, but is preferably 0.005 to 0.1% by weight, more preferably 0.01. It is ~ 0.05% by weight, more preferably 0.01 to 0.02% by weight. Here, the sodium concentration may be calculated based on known information such as a food composition table, or may be measured and calculated by a conventional method. As the sodium contained in the hydration agent of the present invention, a high-purity component such as a chemical product (reagent or the like) may be used, or a raw material containing sodium or a food or drink may be used, for example. Milk raw materials and dairy products containing sodium derived from milk may be used.

The sugar (carbohydrate) contained in the hydration agent of the present invention is not limited to its origin or form, and is, for example, lactose, sugar, fructose, glucose, maltose, trehalose, isomaltulose (as a commercial product, for example, for example). , Palatinose (manufactured by Mitsui Sugar Co., Ltd.), oligosaccharides, dextrin, starch, dietary fiber. The sugar is preferably lactose, sugar, glucose, maltose, trehalose, isomaltulose, or dextrin in terms of enhancing the water retention effect for a long period of time. Further, this sugar may be used alone or in combination of two or more. Here, the sugar concentration may be calculated based on known information such as a food composition table, or may be measured and calculated by a conventional method. The sugar used in the present invention may be a high-purity component such as a chemical product (reagent or the like), or a raw material or food or drink containing sugar may be used, for example, derived from milk. You may use a dairy raw material or a dairy product containing a sugar (the main component is lactose). Alternatively, this sugar may be a food additive known as a sugar so as to have a desired concentration.

The sugar contained in the hydration agent of the present invention is not particularly limited as long as the effects of the present invention are exhibited, but from, for example, trehalose, sucrose, isomaltulose, maltose, lactose, glucose, and dextrin. It contains one or more selected from the group, preferably trehalose and / or isomaltulose, and more preferably trehalose. By containing trehalose in the hydration agent of the present invention, the separation and precipitation of the hydration agent can be suppressed, the redispersibility is good, and the characteristics of a low viscosity and easy-to-drink form can be further imparted. Trehalose is also commercially available, and for example, trehalose (manufactured by Hayashibara Co., Ltd.) can be used.

The concentration of the sugar contained in the hydration agent of the present invention is not particularly limited as long as the effect of the present invention is exhibited, but is preferably 0.1 to 10% by weight, more preferably 1 to 6% by weight. %, More preferably 2-3% by weight.

The stabilizer contained in the hydration agent of the present invention is not particularly limited as long as the effect of the present invention is exhibited, but preferred examples thereof include soybean polysaccharide, HM pectin, and fibrous insoluble cellulose. More preferably, it contains 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of HM pectin, and 0.01 to 0.1% by weight of fibrous insoluble cellulose. Is. According to another aspect of the invention, milk protein, sodium, carbohydrates, 0.2-1.2 wt% soybean polysaccharide, 0.1-0.5 wt% HM pectin, and 0.01-. A hydration agent containing 0.1% by weight of fibrous insoluble cellulose as an active ingredient and being acidic.

The soybean polysaccharide may contain one or more of soybean-derived rhamnose, galactose, arabinose, xylose, glucose, and uronic acid, but cotyledon-derived ones are preferable among soybeans. The molecular weight of the soybean polysaccharide of the present invention is not particularly limited, but it is preferably a high molecular weight, and the average molecular weight is several thousand to several million, specifically 5,000 to 1 million. preferable. The average molecular weight of this soybean polysaccharide is a value obtained by the extreme viscosity method for measuring the viscosity in a _{0.1 MNaNO 3} solution using standard pullulan (Showa Denko KK) as a standard substance. Such soybean polysaccharides are commercially available, and for example, SM-700 (manufactured by Saneigen FFI) or SM-900 (manufactured by Saneigen FFI) can be used. Soybean polysaccharides are said to suppress the separation and precipitation of foods and drinks caused by acid coagulation of casein proteins in foods and drinks due to the structure of their side chains.

The concentration of soybean polysaccharide contained in the hydration agent of the present invention is, for example, 0.1 to 0.5% by weight of HM pectin and 0.01 to 0.1% by weight of the hydration agent of the present invention. When fibrous insoluble cellulose is contained, for example, 0.2 to 1.2% by weight, preferably 0.25 to 1.15% by weight, more preferably 0.3 to 1.1% by weight, and further. It is preferably 0.35 to 1.05% by weight, more preferably 0.4 to 1% by weight, still more preferably 0.4 to 0.9% by weight, still more preferably 0.4 to 0.6% by weight. .. It is preferable that the concentration of the soybean polysaccharide contained in the hydration agent of the present invention is less than 1.2% by weight in order to prevent the hydration agent from being perceived as having a unique flavor of soybean. Further, when the concentration of the soybean polysaccharide contained in the hydration agent of the present invention exceeds 0.2% by weight, the separation and precipitation of the hydration agent of the present invention are suppressed, and further, redispersion is performed. It is preferable for improving the property.

HM pectin is an acidic polysaccharide having α-D-galacturonic acid as a main chain component, which is present in vegetables and fruits as a cell wall component. The galacturonic acid that constitutes pectin is partially methyl esterified, and is divided into LM pectin and HM pectin according to the degree of esterification. HM pectin generally refers to one having a degree of esterification of 50% or more. Such HM pectin is commercially available, for example, SM-478 (manufactured by Saneigen FFI), SM-666 (manufactured by Saneigen FFI), AYD5110SB (manufactured by Unitech Foods). )and so on. HM pectin is characterized by being negatively charged, and it is said that by binding to casein proteins, the bound casein proteins repel each other due to the electric charge, thereby preventing the aggregation of casein proteins.

The concentration of HM pectin contained in the hydration agent of the present invention is 0.2 to 1.2% by weight of soybean polysaccharide and 0.01 to 0.1% by weight of fibrous in the hydration agent of the present invention. In the case of containing insoluble cellulose of, for example, 0.1 to 0.5% by weight, preferably 0.1 to 0.45% by weight, more preferably 0.1 to 0.4% by weight, still more preferably. 0.1 to 0.35% by weight, more preferably 0.1 to 0.3% by weight, still more preferably 0.12 to 0.29% by weight, still more preferably 0.14 to 0.28% by weight, further. It is preferably 0.16 to 0.27% by weight, more preferably 0.18 to 0.26% by weight, still more preferably 0.2 to 0.25% by weight. When the concentration of HM pectin contained in the hydration agent of the present invention is less than 0.5% by weight, the hydration agent contains a milk protein containing a high concentration of casein, yet has a low viscosity and is easy to swallow. It is preferable to do so. Further, when the concentration of HM pectin contained in the hydration agent of the present invention exceeds 0.1% by weight, the separation and precipitation of the hydration agent are suppressed, and the redispersibility is also good. It is preferable to do so.

The fibrous insoluble cellulose can be contained in a hydration agent to construct a three-dimensional network structure in the food and drink, and can improve the dispersibility of insoluble components such as precipitates. can. The fibrous insoluble cellulose suppresses the separation and precipitation of the hydration agent, has good redispersibility, has a low viscosity and is easy to swallow, and has no limitation on its origin, and is derived from plants and / or. Those derived from microorganisms can be used. The fibrous insoluble cellulose derived from a microorganism is, for example, a fermented cellulose produced by a microorganism separated from a medium, washed, and appropriately purified into a fibrous form. The fibrous insoluble cellulose is, for example, fibrous insoluble cellulose microfibrillated to an average diameter of 0.01 to 0.1 μm (see, for example, Japanese Patent Application Laid-Open No. 2005-245217), or fermented cellulose. The fibrous insoluble cellulose of the present invention is commercially available, and for example, Sun Artist PG (manufactured by San-Ei Gen FFI) and Sun Artist PN (manufactured by San-Ei Gen FFI) are used. be able to.

The concentration of fibrous insoluble cellulose contained in the hydration agent of the present invention is 0.2 to 1.2% by weight of soybean polysaccharide and 0.1 to 0.5% by weight of the hydration agent of the present invention. When the above HM pectin is contained, for example, 0.01 to 0.1% by weight, preferably 0.015 to 0.09% by weight, more preferably 0.02 to 0.08% by weight, still more preferably. 0.025 to 0.085% by weight, more preferably 0.03 to 0.07% by weight, still more preferably 0.03 to 0.065% by weight, still more preferably 0.03 to 0.06% by weight, and further. It is preferably 0.03 to 0.055% by weight, more preferably 0.03 to 0.05% by weight. When the concentration of fibrous insoluble cellulose contained in the hydration agent of the present invention is less than 0.1% by weight, foods and drinks containing milk protein containing a high concentration of casein are not in a low viscosity and easy-to-drink form. This is preferable in avoiding this. Further, when the concentration of the fibrous insoluble cellulose contained in the hydration agent of the present invention exceeds 0.01% by weight, the separation and precipitation of the hydration agent cannot be suppressed, and further, the redispersion cannot be suppressed. It is preferable in order to prevent the property from becoming poor.

The hydration agent of the present invention may contain lipids. The origin and form of this lipid are not limited, and its raw materials include, for example, raw milk, whole fat concentrated milk, whole fat powder milk, (fresh) cream, butter, vegetable oil, fish oil, lard, head, and medium chain triacyl. Glycerol oil can be mentioned. And, this "lipid" is preferably raw milk, whole fat concentrated milk, whole fat powder milk, (fresh) cream, butter as raw materials in that the sweetness and richness derived from the fat are good. That is, milk fat is preferable. The "lipid" may be used alone or in combination of two or more. Here, the lipid content may be calculated based on known information such as, for example, a food composition table, or may be measured and calculated by a conventional method. As the "lipid" used in the present invention, a raw material containing a lipid or a food or drink may be used, and for example, a dairy raw material or a dairy product containing a lipid derived from milk may be used. Alternatively, the "lipid" may be a known food additive used in a desired concentration.

When the hydration agent of the present invention contains a lipid, the lipid content thereof is preferably 3.9% by weight or less per hydration agent when adjusted as a mixture containing a predetermined amount of water. At this time, the hydration agent of the present invention exerts its hydration effect and / or hydration retention effect even if it does not contain lipids, but when it contains lipids, it gives a rich feeling derived from lipids. It is preferable in that it can be imparted. Therefore, according to a preferred embodiment of the present invention, in the hydration agent of the present invention, the lipid content is preferably 0.3 to 3.9 per hydration agent when adjusted as a mixture containing a predetermined amount of water. %% by weight, more preferably 0.5 to 3.5% by weight, even more preferably 0.8 to 3.0% by weight, particularly preferably 1.0 to 2.5% by weight, most preferably 1.2 to 2% by weight. It is 0.0% by weight.

According to one embodiment of the present invention, the hydration agent of the present invention exerts its effect even if it does not contain lipids, so that a subject whose intake of lipids needs to be limited, for example, a lifestyle. It can exert an efficient water retention effect on subjects suffering from diseases and dyslipidemia. At this time, the hydration agent of the present invention preferably does not contain lipids, but when a dairy raw material or a dairy product is used as the raw material, it is difficult to completely remove the lipids. The hydration agent of the present invention contains at least about 0.05% by weight of lipid per hydration agent when prepared as a mixture containing a predetermined amount of water. Specifically, when a dairy raw material or a dairy product is used as the raw material, the lipid content of the hydration agent of the present invention is preferably 0. 05 to 3.7% by weight, more preferably 0.05 to 3.5% by weight, still more preferably 0.05 to 3.0% by weight, still more preferably 0.05 to 2.5% by weight, still more preferably. 0.05 to 2.0% by weight, more preferably 0.05 to 1.7% by weight, still more preferably 0.05 to 1.5% by weight, particularly preferably 0.05 to 1.3% by weight, most It is preferably 0.05 to 1.0% by weight.

The hydration agent of the present invention may contain water, wherein the water may be water in the body and is ingested simultaneously with or separately from the hydration agent of the present invention. It means, for example, tap water, mineral water, well water, distilled water, pure water, and carbonated water. When the hydration agent of the present invention is prepared as a mixture containing a predetermined amount of water, the predetermined amount of water is preferably 75.1 to 99.35% by weight per hydration agent.

The hydration agent of the present invention may be in a form containing a predetermined amount of water or as a mixture containing an amount of water less than the predetermined amount (liquid form) as long as the effect is exhibited. , A form in which a predetermined amount of water is substantially removed (dry form) may be used, for example, solid form (powder form, granular form, capsule form, block form, etc.), liquid form, gel form, paste form, etc. It can take the form of a paste or the like. In the case of the hydration agent of the present invention, in the case of a solid state, the water content can be separated, so that the storage stability and portability can be improved. As a result, it can be said that the processability is good and the storage stability is high.

According to one aspect of the present invention, the hydration agent of the present invention is preferably ingested so as to have a body weight of 0.07 g / kg or more per serving, preferably 0.1 to 4.4 g / kg. , More preferably 0.2 to 2.7 g / kg, still more preferably 0.2 to 1.8 g / kg, and particularly preferably 0.2 to 0.9 g / kg. Here, the typical body weight of the subject is estimated to be 60 kg. In the hydration agent of the present invention, the water content may be appropriately adjusted so that the amount of one meal taken when prepared as a mixture containing water is, for example, 200 to 1000 ml, preferably 400 to 1000 ml. can.

According to another aspect of the present invention, for example, the hydration agent of the present invention comprises a unit package form per serving, and the unit package form contains milk protein, sodium, sugar, and a stabilizer. The one-meal intake is, for example, adjusted to 1 to 26 g, preferably adjusted to 4 to 26 g, and in another embodiment, preferably 2 to 16 g, more preferably 2 to 13 g, still more preferable. Is adjusted to 2 to 11 g. Here, "unit packaging form per meal" means that the intake amount per meal is a predetermined form. For example, as a food or drink that can be orally ingested in a specific amount, not only general foods but also general foods It means the form of beverages (drinks, etc.), health supplements, foods with health claims, supplements, etc. In the "unit packaging form per serving", for example, in the case of liquid beverages, gel-like, paste-like or paste-like jelly, powder-like, granular-like, capsule-like, or block-like solid foods, etc. , Metal cans, glass bottles (bottles, etc.), plastic containers (PET bottles, etc.), packs, pouches, film containers, paper boxes, and other packaging containers that can specify a specific amount (dose), or intake per serving (usage) , Dosage) can be displayed on the packaging container, homepage, etc. to specify a specific amount. In the hydration agent of the present invention, the water content may be appropriately adjusted so that the amount of one meal taken when prepared as a mixture containing water is, for example, 200 to 1000 ml, preferably 400 to 1000 ml. can.

According to another aspect of the present invention, for example, in the hydration agent of the present invention, 4 to 26 g of "milk protein, sodium, sugar, and stabilizer" when the form is a so-called healthy drink. Adjust the water content so that the suspended or dissolved beverage has a drinking capacity (dose) of 200 to 1000 ml per serving, for example, metal cans, glass bottles (bottles, etc.), plastic containers (PET bottles, etc.). ) Is contained (filled) in the packaging container. Alternatively, a beverage in which 4 to 26 g of "milk protein, sodium, sugar, and stabilizer" is suspended or dissolved can be used in a packaging container, homepage, etc. There is a form in which several meals (several times) are collectively stored in a large-capacity packaging container or the like.

The manufacturing process (manufacturing procedure) of the hydration agent of the present invention is not limited as long as it is manufactured so as to contain a predetermined component. Can be manufactured based on. The hydration agent of the present invention has, for example, various components such as milk protein and milk fat with respect to raw milk (raw milk), sterilized milk, concentrated milk, powdered milk, and reduced milk according to a known production method (production method). It can be manufactured by blending (adjusting), or by blending (adjusting) various ingredients such as milk protein and milk fat with ingredient-adjusted milk and processed milk (low-fat milk, non-fat milk, etc.). ) Can also be manufactured.

The hydration agent of the present invention has high heat resistance (heat stability) and exhibits a heat resistant effect. Here, "having a heat-resistant effect" means that the protein does not solidify (aggregate) due to heat denaturation even if it is treated at a specific temperature. Specifically, it is a condition used in a general processing treatment of milk. It means that the protein does not undergo heat denaturation even if it is sterilized by heating by the above method. That is, it is said that the hydration agent of the present invention has a heat-resistant effect, and more specifically, it is sterilized by heating (LTLT treatment: low temperature and long time heating) at 62 to 65 ° C. for 30 minutes. As a method having the same or higher sterilizing effect, for example, heat sterilization at 120 to 150 ° C. for 1 to 30 seconds (UHT treatment: ultra-high temperature heating) or heat sterilization at 72 ° C. or higher for 15 seconds or longer (HTST treatment: It means that the protein is not easily heat-denied even if it is heated at a high temperature for a short time) or sterilized by heating at 75 ° C. or higher for 15 minutes or longer. At this time, the heat sterilization method includes a batch type in which the treatment liquid is heated and held while stirring using a tank or the like, an indirect heating method using a plate type heat exchanger or a tube type heat exchanger, and a steam injection type heating device. , A known method such as a direct heating method using a steam infusion type heating device, an energization heating method using a Joule heating device, or the like can be used.

The hydration agent of the present invention has a heat resistant effect. Therefore, in the composition containing (added, mixed) the hydration agent of the present invention, since the hydration agent of the present invention exerts a heat-resistant effect, it can be preferably provided as a liquid product form. , Can be provided as a product form for heated sales using a hot vendor or the like.

Further, the form of the composition containing (adding, mixing) the hydration agent of the present invention is a form as a mixture containing a predetermined amount of water of the hydration agent of the present invention as long as the effect is exhibited. Alternatively, it may be in the form of a mixture containing an amount of water less than a predetermined amount of water (liquid form) or in a form in which the predetermined amount of water is substantially removed (dry form), for example. It can take the form of solid (powder, granule, capsule, block, etc.), liquid, gel, paste, paste, etc. When the composition is provided by blending a hydration agent of the present invention containing less than a predetermined amount of water or substantially removing the water, the composition of the present invention is ingested. Alternatively, upon administration, it is desirable to ingest or administer the required amount of water at the same time as or separately from the composition.

According to another aspect of the present invention, a hydration milk food or drink containing milk protein, sodium, sugar, and a stabilizer as active ingredients and being acidic is provided. The hydration milk food and drink of the present invention may be a hydration food and drink composition. Further, the hydration milk food and drink is preferably a hydration maintenance milk food and drink. The food and drink of the present invention takes the form of solid (powder, granule, capsule, block, etc.), liquid, gel, paste, paste, etc., similarly to the hydration agent of the present invention. be able to. The hydration milk food and drink has an effect based on the characteristic that water absorption into the living body is fast, or an effect based on the property that water absorption into the living body is fast and water is retained in the living body for a long time. Including goods.

The food and drink of the present invention refers to food and drink containing milk and / or dairy products. Here, the milk is, for example, milk derived from mammals such as milk, sheep milk, goat milk, buffalo milk, noodle sheep milk, camel milk, whale milk, dolphin milk, and human milk. Further, here, the dairy product is a processed milk, and is known as a liquid raw material, for example, defatted milk, partially defatted milk, desalted defatted milk, defatted milk, ingredient-adjusted milk, whey, concentrated milk. , Degreased concentrated milk, partially defatted concentrated milk, desalted defatted concentrated milk, brick milk, cream, permeate derived from dairy raw material prepared by a known method, milk protein concentrate prepared by a known method, etc. can also be used and processed in a known manner. Ingredients such as powdered milk, butter, concentrated milk, milk, lactose, milky minerals and the like can also be used.

In addition, the foods and drinks of the present invention include health foods, functional foods, nutritional supplements, foods for specified health use, foods for the sick, prepared milk powder for infants, milk powder for pregnant or lactating women, or sustainable foods. It also includes foods and drinks that are labeled as being used for retaining water.

The milk food and drink of the present invention is preferably a milk beverage.

The pH, milk protein, milk protein concentration, sodium concentration, stabilizer, etc. of the dairy food and drink of the present invention may be the same as those of the hydration agent of the present invention. Further, the method for producing the food or drink of the present invention may be the same as that of the hydration agent of the present invention.

Further, the hydration agent of the present invention may be a "pharmaceutical product" (pharmaceutical composition). That is, according to another aspect of the present invention, a hydration (or hydration retention) drug (pharmaceutical composition) containing milk protein, sodium, sugar, and a stabilizer as active ingredients and is acidic. Things) are provided. A "pharmaceutical product" (pharmaceutical composition) is prepared as an oral preparation or a parenteral preparation according to a conventional method in combination with an additive that is acceptable for formulation. When the drug is an oral preparation, the form of a solid preparation such as tablets, powders, fine granules, granules, capsules, pills and sustained-release agents, and liquid preparations such as solutions, suspensions and emulsions is used. Can be taken. From the viewpoint of simplicity of ingestion (administration) to patients, oral preparations are preferable as pharmaceuticals. Here, additives that are acceptable for formulation include, for example, excipients, stabilizers, preservatives, wetting agents, emulsifiers, lubricants, sweeteners, colorants, flavors, buffers, antioxidants. Examples include agents and pH adjusters. The pharmaceutical product (pharmaceutical composition) of the present invention can be applied to any disease that requires hydration or retention, for example, treatment of dehydration or heat stroke, or It can be used for prevention. In addition, the pharmaceutical agent (pharmaceutical composition) of the present invention is used for treating or preventing diseases caused by lack of water in the body, such as constipation, hypertension, arteriosclerosis, thrombosis, cerebral infarction, myocardial infarction, gout, and cancer. You can also.

According to another aspect of the present invention, a food or drink or a pharmaceutical product for hydration, which contains milk protein, sodium, sugar, and a stabilizer as active ingredients and is acidic. Or the use of medicines is provided.

According to another preferred embodiment of the present invention, the use of foods and drinks or pharmaceuticals for hydrating and retaining hydration, which contains milk protein, sodium, sugar, and stabilizer as active ingredients. , And the use of acidic foods and drinks or medicines is provided.

According to another preferred embodiment of the present invention, foods and drinks or pharmaceuticals for hydrating and / or retaining hydration to a subject in an environment and / or condition in which it is difficult to hydrate and / or retain hydration in the body. The use of foods and drinks or pharmaceuticals containing milk protein, sodium, sugar, and stabilizer as active ingredients and being acidic is provided.

According to another aspect of the present invention, it is used for the production of foods and drinks or pharmaceuticals for hydration, which contains milk protein, sodium, sugar, and stabilizer as active ingredients and is acidic. Is provided for use in the manufacture of foods and drinks or pharmaceuticals.

According to another preferred embodiment of the present invention, the use for the manufacture of foods and drinks or pharmaceuticals for hydrating and retaining hydration, effective for milk proteins, sodium, sugars, and stabilizers. Use is provided for the manufacture of foods and drinks or pharmaceuticals that are contained as ingredients and are acidic.

According to another preferred embodiment of the present invention, milk proteins, sodium, sugars for hydrating and / or retaining a subject in an environment and / or condition in which it is difficult to hydrate and / or retain the body. , And use for the manufacture of foods and drinks or pharmaceuticals that contain stabilizers as active ingredients and are acidic.

According to another aspect of the present invention, the use of a food or drink or medicine containing milk protein, sodium, sugar, and a stabilizer as active ingredients and being acidic for hydration is provided.

According to another aspect of the present invention, the use of foods or drinks or pharmaceuticals containing milk protein, sodium, sugar, and stabilizer as active ingredients and being acidic to rehydrate and retain water. Is provided.

According to another aspect of the present invention, there is provided a food or drink or medicine containing milk protein, sodium, sugar, and a stabilizer as active ingredients and which is acidic for hydration.

According to another aspect of the present invention, a food or drink or a pharmaceutical product containing, as an active ingredient, milk protein, sodium, sugar, and a stabilizer for hydrating and retaining water and being acidic is provided. Will be done.

According to another aspect of the present invention, there is provided a hydration method comprising ingesting the hydration agent or the hydration milk food or drink of the present invention. This subject may be a subject in an environment and / or condition in which it is difficult to rehydrate and / or retain water in the body.

According to another preferred embodiment of the present invention, there is provided a hydration method (excluding medical practice for humans) comprising ingesting the hydration agent or hydration milk food or drink of the present invention. NS. Here, the "medical practice for humans" means an act of ingesting (administering) a drug to a human, requiring a prescription from a doctor or the like. The water retention method of the present invention can be carried out for the water retention agent of the present invention in accordance with the contents described in the present specification.

According to another aspect of the invention, an object, preferably in an environment and / or condition in which it is difficult to hydrate and / or retain the hydration agent of the invention into the body, optionally simultaneously or separately with water. Provided are methods of preventing and / or treating dehydration or heat stroke, including feeding the elderly or children. According to a preferred embodiment of the present invention, the method for preventing and / or treating dehydration or heat stroke is a method excluding medical practice for humans. The method for preventing and / or treating dehydration or heat stroke of the present invention can be carried out according to the contents described in the present specification regarding the method for retaining water of the present invention.

According to another aspect of the present invention, a food or drink for treating or preventing dehydration or heat stroke (food and drink composition) containing milk protein, sodium, sugar, and a stabilizer as active ingredients and being acidic. A product) or a pharmaceutical product (pharmaceutical composition) is provided.

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto. Unless otherwise specified, the measuring method and unit of the present invention shall be in accordance with the provisions of the Japanese Industrial Standards (JIS).

[Test Example 1]
Preparation of milk beverage of the present invention 4.35 kg of milk protein concentrate (80% by weight of milk protein, 6.5% by weight of lactose) was dissolved by heating in 40.65 kg of water to prepare a solution A. 0.45 kg of soybean polysaccharide, 0.2 kg of HM pectin, 0.05 kg of fermented cellulose, 1 kg of trehalose, 3.3 kg of sugar, and 0.0063 kg of sucralose were heated and dissolved in 39.99 kg of water to prepare a solution B. 0.64 kg of citric acid was dissolved in 9.36 kg of water to prepare Solution C. After mixing the solution A and the solution B, the solution C was added in 10 portions over 5 minutes while stirring the mixed solution to prepare a base mix before sterilization. This base mix was homogenized at 15 MPa (70-80 ° C.) with a plate sterilizer, sterilized at 130 ° C. for 2 seconds, and then cooled to 10 ° C. or lower to produce the milk beverage (milk) of the present invention. Protein 3.5% by weight, soybean polysaccharide 0.45% by weight, HM pectin 0.2% by weight, fermented cellulose 0.05% by weight, trehalose 1% by weight) were used in Test Examples 1 and 2 below. The milk beverage of the present invention had a pH of 4.1 and a viscosity of 10 mPa · s (10 ° C.). "Drinking mouth", "precipitation", and "redispersibility" were all good. The milk protein concentrate used here is a casein protein obtained by membrane-separating defatted milk (UF treatment, MF treatment, etc.) to remove lactose and ash, and concentrating mainly casein protein and whey protein. It is a mixture of whey protein and its form is a dry powder. The protein content ratio of the milk protein concentrate is about 8: 2 casein protein: whey protein = about 8: 2, as in raw milk (milk) (see Kunio Yamauchi and Kenkichi Yokoyama, Milk Comprehensive Dictionary).

Measurement of plasma volume change rate A 9-week-old male SD rat (manufactured by Claire Japan) was purchased and acclimatized for 1 week or longer. Rats were allowed to fast for 20 hours and fast for 4 hours. Subsequently, the rat was subjected to distilled water, a sports drink (Pocalisette: manufactured by Otsuka Pharmaceutical Co., Ltd.), milk (Meiji milk: manufactured by Meiji Co., Ltd.), or the milk beverage of the present invention prepared above (hydration) as a test beverage. 20 mL / kg of the drug) was orally administered. Partial blood was collected from the jugular vein before oral administration (0 minutes) and 15 minutes, 30 minutes, 60 minutes, 120 minutes, and 180 minutes after administration under isoflurane anesthesia, and an automatic blood analyzer XT-1800iV (manufactured by Sysmex Corporation). The hematocrit value and blood hemoglobin concentration were measured in. The rate of change in plasma volume (%) was determined from the hematocrit value and hemoglobin concentration. The compositions of the administered sports drink, milk, and milk beverage of the present invention are shown in Table 1 below. Eight animals were used in each group.

Results of plasma volume change rate The plasma volume change rate after oral administration of each beverage is shown in FIG. The milk drink and sports drink of the present invention showed a significantly higher plasma volume after 15 minutes as compared with milk. It was found that the milk beverage of the present invention takes in water into the body faster than milk. In addition, the rate of change in plasma volume of the milk beverage of the present invention was higher than that of the sports drink at any of the time points after 15 minutes, 30 minutes, 60 minutes, 120 minutes, and 180 minutes.

[Test Example 2]
A 9-week-old male SD rat (manufactured by Claire Japan) was purchased and acclimatized for 1 week. Rats were allowed to fast for 20 hours and fast for 4 hours. 20 mL / kg of distilled water, sports drink (Pocalisette: manufactured by Otsuka Pharmaceutical Co., Ltd.), milk (Meiji milk: manufactured by Meiji Co., Ltd.), or the milk beverage of the present invention prepared in Test Example 1 above was orally administered to rats. The milk was transferred to a cage for collecting urine, and the amount of urine excretion was measured until 4 hours later. Seven animals were used in each group.

Results of cumulative urine excretion The cumulative urine excretion after administration of each beverage is shown in FIG. The milk drink of the present invention showed a significantly lower value than the sports drink after 90 minutes (p <0.05) (the statistical method was performed using the Tukey-kramer test, and so on. ). In addition, the milk beverage of the present invention showed a significantly lower value than distilled water after 60 to 240 minutes (p <0.05). The milk drink of the present invention showed a lower cumulative urine excretion value than the sports drink and distilled water. Moreover, it was found that the cumulative urine excretion amount of the milk beverage of the present invention and milk was about the same.

From the above results, it was found that the milk beverage (hydration agent) of the present invention absorbs water into the living body more quickly than milk and increases the plasma volume more rapidly. It was also confirmed that the milk beverage (hydration agent) of the present invention has a higher water retention effect than sports drinks and is almost the same as milk. Further, it was found that the milk drink (hydration agent) of the present invention has a property of rapidly absorbing water into the living body, which is superior to that of sports drinks. Furthermore, it was found that the milk beverage (hydration agent) of the present invention also has an excellent hydration retention effect of milk, and a more effective hydration retention agent having the advantages of milk and sports drinks. It turns out that it can be.
It was also confirmed that not only water absorption and water retention but also absorption of milk protein as an amino acid into plasma is good. It was also confirmed that it is particularly useful for post-exercise intake because hydration and protein supplementation are performed promptly.

Claims (11)

Milk protein, sodium, carbohydrates, 0.2-1.2% by mass of soybean polysaccharides, 0.1-0.5% by mass of HM pectin, and 0.01-0.1% by mass of fibrous insoluble A hydration agent containing cellulose as an active ingredient, having a milk protein concentration of 2 to 7% by weight, and the milk protein containing casein protein and being acidic. The hydration agent according to claim 1, which is for retaining hydration. The hydration agent according to claim 1 or 2, wherein the sodium concentration is 0.005 to 0.1% by weight. The hydration agent according to any one of claims 1 to 3 , wherein the sugar concentration is 0.1 to 10% by weight. The hydration agent according to any one of claims 1 to 4 , wherein the sugar is one or more selected from the group consisting of trehalose, sucrose, isomaltulose, maltose, lactose, glucose, and dextrin. PH hydration dosage is 3-6, hydration dosage according to any one of claims 1-5. Milk protein, sodium, carbohydrates, 0.2-1.2% by mass of soybean polysaccharides, 0.1-0.5% by mass of HM pectin, and 0.01-0.1% by mass of fibrous insoluble A hydration dairy food or drink containing cellulose as an active ingredient, having a milk protein concentration of 2 to 7% by weight, and containing casein protein and being acidic. The milk food or drink for hydration according to claim 7 , which is a milk beverage. A hydration method comprising feeding a subject a hydration agent according to any one of claims 1 to 6 or a hydration milk food or drink according to claim 7 or 8. Use for the manufacture of foods and drinks or pharmaceuticals to rehydrate, milk protein, sodium, carbohydrates, 0.2-1.2% by mass of soybean polysaccharides, 0.1 to 0.5% by mass It contains% HM pectin and 0.01-0.1% by mass of fibrous insoluble cellulose as active ingredients, has a milk protein concentration of 2-7% by weight, and the milk protein contains casein protein. And use for the manufacture of acidic foods and drinks or pharmaceuticals. Milk protein, sodium, carbohydrates, 0.2-1.2% by mass of soybean polysaccharides, 0.1-0.5% by mass of HM pectin, and 0.01-0.1 by weight for hydration A food or drink or a drug containing mass% fibrous insoluble cellulose as an active ingredient, having a milk protein concentration of 2 to 7% by weight, and containing casein protein and being acidic.

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