JP7165977B2 - toothpaste - Google Patents

Description

The present invention relates to dentifrices .

As oral compositions, there are various oral compositions ranging from oral compositions that simply physically remove stains adhering to teeth to oral compositions containing medicinal ingredients in anticipation of various medicinal effects. there is a thing

In particular, compositions for the oral cavity containing botanical components (especially crude drug components with a long history) that are components derived from natural products have been proposed (see Patent Documents 1 and 2).

In addition, inhibitors containing plant components have also been proposed as biofilm inhibitors for food applications (see Patent Document 3).

However, in recent years, oral compositions are required to further improve the effect of suppressing the formation of periodontal bacterial plaque.

JP 2015-54847 A JP-A-6-25000 JP 2014-34552 A

An object of the present invention is to provide a dentifrice containing a plurality of herbal medicines and having an effect of suppressing the formation of periodontal bacterial plaque, which is effective at a lower dose than when a single herbal medicine is used.

Such objects are achieved by the present invention of the following (1) to ( 4 ).
(1) A dentifrice containing Scutellaria root, Rhubarb and Bellflower,
The content of the Scutellaria root in the dentifrice is 0.01% by mass or more and 0.5% by mass or less, and the content of the Bellflower in the dentifrice is 0.05% by mass or more and 2% by mass or less, A dentifrice characterized by containing 0.4% by mass or more and 2% by mass or less of said rhubarb in said dentifrice, and containing no cinnamon bark .

( 2 ) When the content of Scutellaria root in the dentifrice is X _A [mass%], and the content of the rhubarb in the dentifrice is _Xc [mass%], 4 ≤ X _C /X _A ≤ The dentifrice according to ( 1 ) above, which satisfies the relationship of 120 .

( 3 ) When the content of the bellflower in the dentifrice is XB [mass%], and the content of the rhubarb in the dentifrice is _Xc [mass%], _0.0005 ≤ _XC /X The dentifrice according to ( 1 ) or ( 2 ) above, which satisfies the relationship of _B ≤ 20000.

( 4 ) The dentifrice according to any one of (1) to ( 3 ) above, wherein the content of the rhubarb in the dentifrice is higher than the content of the scutellaria root in the dentifrice.

According to the present invention, it is possible to provide a dentifrice containing a plurality of herbal medicines and having an effect of suppressing the formation of periodontal bacterial plaque, which is effective at a lower dose than when a single herbal medicine is used.

Preferred embodiments of the present invention are described in detail below.
<<Composition for oral cavity>>

As oral compositions, there are various oral compositions ranging from oral compositions that simply physically remove stains adhering to teeth to oral compositions containing medicinal ingredients in anticipation of various medicinal effects. there is a thing

In particular, there are documents describing compositions for the oral cavity containing botanical components (especially crude drug components with a long history) that are components derived from natural products.

However, in recent years, there has been a demand for further improvement in the effect of suppressing the formation of periodontal bacterial plaque.

Therefore, as a result of intensive research, the present inventors have found that by using a combination of Scutellaria root and Bellflower, among various crude drugs, in an oral composition, they act synergistically, and excellent effects can be obtained. I found

That is, the oral composition of the present invention contains Scutellaria root and Bellflower. By including these together, an excellent formation inhibitory effect on periodontal plaque can be obtained. In particular, when a crude drug component alone is used, even when the content is so low that no effect can be obtained, a sufficiently excellent effect of inhibiting the formation of periodontal plaque can be obtained.

Although the above-mentioned documents describe various crude drugs, they do not specifically disclose oral compositions using a combination of Scutellaria root and Bellflower.

In the present invention, the oral composition may contain Scutellaria root and Bellflower, for example, as it is after pulverizing dried plants, or may contain an extraction solvent such as water or an organic solvent, or an extraction medium such as a supercritical fluid. It may be included as an extract extracted using or a component obtained by removing the extraction medium from the extracted extract (hereinafter collectively referred to as an extract).

In particular, the oral composition preferably contains at least one of Scutellaria root and Bellflower as an extract, and more preferably contains both Scutellaria root and Bellflower as extracts.

As a result, it is possible to suppress variations in quality between manufacturing lots, and to obtain stable quality.

In addition, the composition for oral cavity can contain preferable components among natural product-derived components at a relatively high content rate, and can suppress the content rate of unfavorable components to a low level. As a result, for example, it is possible to prevent the deterioration of the color tone, flavor, etc. of the composition for oral cavity, and more reliably exhibit the expected effects. Also, excellent stability of the active ingredient in the oral composition can be obtained. Therefore, the storage stability of the oral composition as a whole is improved, the shelf life of the oral composition can be extended, and the storage conditions can be relaxed.

As an extraction solvent for obtaining an extract of Scutellaria root and Bellflower, for example, various inorganic solvents and various organic solvents can be used. More specifically, water; monovalent alcohols such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol, octanol, phenol; propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1, 4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, glycerin, polyethylene glycol (molecular weight 100- 100,000); ketones such as acetone and methyl ethyl ketone; esters such as ethyl acetate and methyl acetate; ethers such as diethyl ether, dimethyl ether, ethyl methyl ether and dioxane; nitriles such as acetonitrile; Halides such as carbon tetrachloride; aliphatic hydrocarbons such as hexane, octane and cyclohexane; aromatic hydrocarbons such as xylene, toluene and benzene; can be used. In addition, as an extraction solvent, an acid (e.g., hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) or an alkali (e.g., sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia etc.) may be used.

Among them, it is preferable to use an aqueous ethanol solution as the extraction solvent for obtaining the Scutellaria root extract.
As a result, the effects as described above are exhibited more remarkably.

In particular, the concentration of the aqueous ethanol solution (the ethanol content) of the extraction solvent for obtaining the Scutellaria root extract is preferably 30% by volume or more and 95% by volume or less, and 40% by volume or more and 70% by volume or less. is more preferred.
As a result, the effects as described above are exhibited more remarkably.

Moreover, as an extraction solvent for obtaining the extract of Bellflower, it is preferable to use a solvent containing water.
As a result, the effects as described above are exhibited more remarkably.

In particular, the content of water contained in the extraction solvent for obtaining the extract of Bellflower is preferably 90% by mass or more, more preferably 95% by mass or more.
As a result, the effects as described above are exhibited more remarkably.

In the oral composition, Scutellaria root and Bellflower may be contained in any form, for example, may be contained in the form of powder or granules, may be contained as an oily component, or may be added to other components. It may be included in a dissolved state.

The content of Scutellaria root (the content of Scutellaria root in a dry state) in the oral cavity composition is not particularly limited, but is preferably 0.0001% by mass or more and 2% by mass or less, and 0.0005% by mass or more and 0.005% by mass or less. It is more preferably 5% by mass or less, and even more preferably 0.005% by mass or more and 0.05% by mass or less.

If the content of Scutellaria root is less than the lower limit, the effect of the present invention may not be sufficiently exhibited depending on the content of Bellflower.

Moreover, when the content of scutellaria root exceeds the above upper limit, problems such as a problem of coloration and a decrease in feeling during use due to an unpleasant taste such as bitterness may occur more remarkably.

The content of Bellflower in the composition for oral use (content of Bellflower in a dry state) is not particularly limited, but is preferably 0.0001% by mass or more and 2% by mass or less, and 0.001% by mass or more and 1% by mass. % or less, and more preferably 0.025 mass % or more and 0.5 mass % or less.

If the content of Bellflower is less than the above lower limit, the effects of the present invention may not be sufficiently exhibited depending on the content of Scutellaria root and the like.

Further, when the content of Bellflower exceeds the above upper limit, there are cases where problems such as coloring and a decrease in usability due to unpleasant taste such as bitterness occur more remarkably.

When the content of Scutellaria root in the oral composition is X _A [% by mass] and the content of Bellflower in the oral composition is X _B [% by mass], 0.00005 ≤ X _B /X _A ≤ 20000 preferably satisfies the relationship of 0.002≦X _B /X _A ≦2000, more preferably satisfies the relationship of 0.5≦X _B /X _A ≦100 .

As a result, it is possible to obtain a more excellent effect of suppressing the formation of periodontal disease plaque, and it is possible to obtain more excellent storage stability and the like of the composition for oral cavity.

The oral composition of the present invention preferably contains Rhubarb in addition to Scutellaria root and Bellflower.

Thus, by using Rhubarb, which is not known to have a periodontal disease plaque formation inhibitory effect alone, in combination with Scutellaria root and Bellflower, they act synergistically to further improve periodontal disease plaque. formation suppression effect can be obtained. In particular, even when Rhubarb is added to an oral composition at a concentration that is completely ineffective when used alone, a particularly excellent effect of suppressing the formation of periodontal disease plaque can be obtained by using it in combination with Scutellaria root and Bellflower.

When the oral composition contains Rhubarb, the oral composition may contain the Rhubarb, for example, as it is after pulverizing a dried plant, or may contain an extraction solvent such as water or an organic solvent, or a supercritical fluid. It may be contained as an extract extracted from a plant using an extraction medium or as a component (extract) obtained by removing the extraction medium from this extract.

In particular, the oral composition more preferably contains Rhubarb as an extract.
As a result, it is possible to suppress variations in quality between manufacturing lots, and to obtain stable quality.

In addition, the composition for oral cavity can contain a relatively high content of preferable components contained in the natural product of rhododendron, and the content of unfavorable components can be suppressed to a low level. As a result, for example, it is possible to prevent the deterioration of the color tone, flavor, etc. of the composition for oral cavity, and more reliably exhibit the expected effects. Also, better stability of the active ingredient in the oral composition can be obtained. Therefore, the storage stability of the oral composition as a whole is improved, the shelf life of the oral composition can be extended, and the storage conditions can be relaxed.

As the extraction solvent for obtaining the extract of Rhizoma serrata, for example, the solvent exemplified as the extraction solvent for obtaining the extract of Scutellaria root and Bellflower can be used.

Among them, it is preferable to use an ethanol aqueous solution as an extraction solvent for obtaining an extract of Rhizophora chinensis.
As a result, the effects as described above are exhibited more remarkably.

In particular, the concentration (content of ethanol) of the aqueous ethanol solution as the extraction solvent for obtaining the extract of Rhizoma is preferably 30% by volume or more and 95% by volume or less, and is preferably 40% by volume or more and 70% by volume or less. is more preferred.
As a result, the effects as described above are exhibited more remarkably.

In the oral composition, rhubarb may be contained in any form, for example, it may be contained in the form of powder, granules, may be contained as an oily component, or may be dissolved in other components. state may be included.

Although there is no particular limitation on the content of Rhubarb (the content of Rhubarb in a dry state) in the oral composition, it is preferably 0.001% by mass or more and 2% by mass or less, and 0.05% by mass or more and 1% by mass. % or less, and more preferably 0.2 mass % or more and 0.6 mass % or less.

If the content of the rhizome is less than the lower limit, the effect of containing the rhizome may not be sufficiently exhibited.

On the other hand, if the content of sulfide exceeds the above upper limit, problems such as coloring problems and unpleasant tastes such as bitterness and the like may occur more remarkably.

When the content of Scutellaria root in the oral composition is X _A [% by mass], and the content of Rhizophora in the oral composition is X _C [% by mass], 0.0005≦X _C /X _A ≦20000 , more preferably 0.1≦X _C /X _A ≦2000, and even more preferably 4≦X _C /X _A ≦120.

As a result, it is possible to obtain a more excellent effect of suppressing the formation of periodontal disease plaque, and to obtain more excellent storage stability and the like of the composition for oral cavity.

When the content of Bellflower in the oral composition is X _B [% by mass], and the content of Rhubarb in the oral composition is X _C [% by mass], 0.0005≦X _C /X _B ≦20000 preferably satisfies the relationship of 0.05≦X _C /X _B ≦1000, more preferably satisfies the relationship 0.4≦X _C /X _B ≦24 .

As a result, it is possible to obtain a more excellent effect of suppressing the formation of periodontal disease plaque, and to obtain more excellent storage stability and the like of the composition for oral cavity.

The oral composition of the present invention may contain components other than those described above.
Examples of such components (other components) include abrasives, wetting agents, solvents, binders, flavors, excipients, sweeteners, pH adjusters, preservatives, emulsifiers, solubilizers, and foaming agents. , lubricants, oils, surfactants, coloring agents, antioxidants, chelating agents, flavoring agents, moisturizing agents, antibacterial agents, anti-inflammatory agents, fluorides, vitamins, crude drugs other than those mentioned above, and the like.

Examples of abrasives include silica-based abrasives such as silica gel, precipitated silica, igneous silica, hydrous silicic acid, silicic anhydride, aluminosilicate and zirconosilicate; dicalcium phosphate dihydrate, dicalcium phosphate Calcium hydrogen phosphate for toothpaste such as anhydrate; Calcium carbonate such as light calcium carbonate and heavy calcium carbonate; Calcium phosphate, trimagnesium phosphate, tricalcium phosphate, insoluble calcium metaphosphate, calcium pyrophosphate, aluminum hydroxide, aluminum oxide , magnesium carbonate, zirconium silicate, titanium dioxide, synthetic resin abrasives, zeolite, etc., and one or more selected from these may be used in combination.

In particular, the oral composition preferably contains an abrasive composed of a porous body.

As a result, the aforementioned herbal medicine components (especially Scutellaria root extract and Bellflower extract) can be carried in the pores of the abrasive (porous body), and the bitter taste of the herbal medicine can be reduced.

Among the various abrasives described above, it is particularly preferable to use zeolite.
By using zeolite, herbal medicine components (particularly Scutellaria root extract and Bellflower extract) can be more favorably supported in the pores of the abrasive (porous body), thereby reducing the bitterness of herbal medicines. be able to.

Examples of humectants include polyhydric alcohols such as glycerin, sorbitol, polyethylene glycol, propylene glycol, ethylene glycol, 1,3-butylene glycol, polypropylene glycol, xylitol, maltitol, and lactitol. can be used alone or in combination of two or more.

As the solvent, for example, an organic solvent such as alcohol or water is preferable, and examples thereof include ethanol, propyl alcohol, isopropyl alcohol, etc. Ethanol is particularly preferable.

Examples of binders include cellulose derivatives such as carrageenan, carboxymethylcellulose and sodium carboxymethylcellulose; alkali metal alginates such as sodium alginate; gums such as xanthan gum, tragacanth gum and gum arabic; synthetic viscosity agents such as polyvinyl alcohol and sodium polyacrylate; Binders and the like can be mentioned, and one or more selected from these can be used in combination.

Examples of fragrances include l-menthol, l-carvone, cinnamic aldehyde, orange oil, anethole, 1,8-cineol, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol. , pinene, spiranthol, ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methyl phenyl glycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, maltol, ethyl maltol, gamma/delta decalactone, Fragrance ingredients such as gamma/delta decalactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, ethylene glycol-l-menthyl carbonate; peppermint oil, spearmint oil, eucalyptus oil, clove oil, thyme oil, sage Natural essential oils such as oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil, lavender oil, paracress oil; apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, Known flavor materials such as mixed flavors such as squash, coffee, brandy, and yogurt can be mentioned, and one or more selected from these can be used in combination.

Excipients include, for example, sucrose, lactose, starch, glucose, crystalline cellulose, mannitol, sorbitol, xylitol, erythritol, palatinit, palatinose, maltitol, trehalose, lactitol, lactulose, reduced starch sugar, reduced isomaltooligo sugar, coupling sugar, gum base, gum arabic, gelatin, cetylmethylcellulose, light anhydrous silicic acid, magnesium aluminate, calcium aluminometasilicate, sodium hydrogen carbonate, calcium phosphate, etc., and one or two selected from these More than one species can be used in combination.

Examples of sweeteners include palatinit, aspartame, saccharin sodium, acesulfame potassium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perillarmin, thaumatin, asparatylphenylalanylmethyl ester, ρ-methoxycinnamic aldehyde and the like. , or a combination of two or more selected from these.

pH adjusters include, for example, citric acid, phosphoric acid, pantothenic acid, malic acid, pyrophosphoric acid, lactic acid, tartaric acid, glycerophosphate, acetic acid, nitric acid, or disodium hydrogen phosphate or any of these chemically possible Salts, sodium hydroxide and the like can be mentioned. These can be used alone or in combination of two or more selected from them so that the pH of the composition is in an appropriate range.

Examples of the antiseptic include paraoxybenzoic acid esters, benzoic acid and its salts, salicylic acid and its salts, sorbic acid and its salts, phenoxyethanol, alkyldiaminoethylglycine hydrochloride, etc., and one or more selected from these. Two or more kinds can be used in combination.

Examples of emulsifiers include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, sodium stearoyl lactylate, soybean Phospholipids, alkyltrimethylammonium chloride and the like can be mentioned, and one or more selected from these can be used in combination.

Examples of solubilizers include esters, polyethylene glycol derivatives, polyoxyethylene hydrogenated castor oil, fatty acid esters of sorbitan, sulfated fatty alcohols, etc. One or more selected from these may be used. They can be used in combination.

Examples of foaming agents include sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium alkylsulfosuccinate, sodium coconut oil fatty acid monoglycerol sulfonate, sodium α-olefin sulfonate, N-acylamino acid salts such as N-acylglutamate, 2- Alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, maltitol fatty acid ester, sucrose fatty acid ester, polyglycerin fatty acid ester, fatty acid diethanolamide, polyoxyethylene sorbitan monostearate, polyoxyethylene hydrogenated castor oil, Polyoxyethylene fatty acid esters and the like can be mentioned, and one or more selected from these can be used in combination.

Lubricants include, for example, magnesium stearate, sucrose fatty acid esters, talc, hardened oils, etc., and one or more selected from these may be used in combination.

Examples of oils include coconut oil, olive oil, sesame oil, peanut oil, parsley oil, parsley seed oil, and safflower oil, and one or more selected from these can be used in combination.

Examples of surfactants include sodium lauryl sulfate, sodium α-olefin sulfonate, sodium dodecylbenzene sulfonate, sodium lauryl sulfoacetate, sodium N-lauroyl sarcosinate, N-acylglutamate, sucrose fatty acid ester, polyoxy Ethylene Hydrogenated Castor Oil, Polyoxyethylene Polyoxypropylene Block Copolymer, Alkyl Glycosides, Sorbitan Fatty Acid Ester, Polyoxyethylene Sorbitan Fatty Acid Ester, Alkyldimethylamine Oxide, Lauryl Ethanolamide, Sodium Cocoyl Sarcosinate, N-Lauroyl Methyl Taurine Sodium liquid and the like can be mentioned, and one or more selected from these can be used in combination.

Examples of the coloring agent include dyes such as Blue No. 1, pigments such as titanium dioxide, various dyes, and the like, and one or more selected from these can be used in combination.

Examples of antioxidants include dibutylhydroxytoluene, butylhydroxyanisole, erythorbic acid, propyl gallate, octyl gallate, d-δ-tocopherol, vitamin C, vitamin E, disodium edetate, calcium gluconate, and the like. be done.
Chelating agents include, for example, edetate and the like.

The corrigents include, for example, tea extract, dried distillate of tea, sodium glutamate and the like, and one or more selected from these can be used in combination.

Examples of moisturizing agents include amino acids or salts thereof, pyrrolidone carboxylic acid, mucin, hyaluronic acid or salts thereof, mucopolysaccharides such as chondroitin sulfate, sodium lactate, urea, panthenol, aloe extract, rosemary extract, thyme extract, Natural extract components such as tea extract (dry-distilled tea extract), so-called extracellular matrices such as collagen and elastin, and the like can be mentioned, and one or more selected from these can be used in combination.

Examples of antibacterial agents include phenolic antibacterial agents such as isopropylmethylphenol, triclosan, hinokitiol, and thymol; Chlorhexidine, lactoferrin, paraben, butylparaben and the like can be mentioned, and one or more selected from these can be used in combination.

Examples of anti-inflammatory agents include lysozyme chloride, ε-aminocaproic acid, aluminum hydroxylalantoin, glycyrrhetinic acid, glycyrrhizinates, guaiazulene sulfonic acid, dl-α-tocopherol acetate, and the like, and 1 selected from these A species or a combination of two or more species can be used.

Examples of fluorides include sodium fluoride, potassium fluoride, sodium monofluorophosphate, and stannous fluoride, and one or more selected from these may be used in combination. can.

Examples of vitamin preparations include vitamin A such as retinoic acid and β-carotene, pantothenic acid or salts thereof, B vitamins such as niacin and biotin, vitamin C such as ascorbic acid or its salts and derivatives, and α-tocopherol. and folic acid, etc., and one or more selected from these can be used in combination.

Herbal medicines other than those mentioned above include, for example, chamomile, valerian, jujube, hops, lamender, linden, Chinese quince, kingpinka, kumazasa, gummy, clove, ginseng, salvia, soappink, cinnamon bark, bukuryo, peony, hawthorn, angelica, tea, It can be used alone, or in combination of two or more selected from them.

When the oral composition contains the above herbal medicine, the oral composition may contain the above crude medicine as it is, for example, by pulverizing a dried plant, or may be mixed with water, an organic solvent, or the like. It may be included as an extract extracted using an extraction medium such as an extraction solvent or a supercritical fluid, or as a component (extract) obtained by removing the extraction medium from this extraction extract.

The form of the oral composition is not particularly limited, and examples thereof include liquid (emulsified form, solubilized form), liquid form, gel form, paste form, tablet, effervescent tablet, powder form, granule form and the like.

Uses of oral compositions include, for example, toothpastes, toothpastes, liquid toothpastes, dentifrices such as liquid dentifrices; lozenges; tablets (including effervescent tablets, etc.); creams; ointments; oral moisteners; mouthwashes; mouth fresheners; tablets for gargling; denture stabilizers; denture cleansers;

<<Method for producing oral composition>>
The oral composition of the present invention can be obtained by mixing each component as described above.

In particular, when the composition for oral cavity contains a porous body, it is preferable to preliminarily mix the crude drug as described above with the porous body, and then mix it with other ingredients.

As a result, the herbal medicine can be more preferably supported in the pores of the porous body.

Although the preferred embodiments of the present invention have been described above, the present invention is not limited to the above.

EXAMPLES The present invention will be described in detail below based on Examples and Comparative Examples, but the present invention is not limited thereto.

<<1>> Production of Liquid Compositions Liquid compositions according to each example and each comparative example were produced as follows.

(Example 1)
Freeze-dried powder of Scutellaria root extract-J (manufactured by Maruzen Pharmaceutical Co., Ltd.) as a Scutellaria root extract, and dried bellflower extract-S (manufactured by Alps Pharmaceutical Co., Ltd.) as a bellflower extract are mixed with a predetermined amount (see Table 1) of water. to obtain a liquid composition.

(Example 2)
Freeze-dried powder of Scutellaria root extract-J (manufactured by Maruzen Pharmaceutical Co., Ltd.) as a Scutellaria root extract, dried bellflower extract-S (manufactured by Alps Pharmaceutical Co., Ltd.) as a bellflower extract, and Rhizoma extract as Rhizoma extract- A predetermined amount (see Table 1) of the freeze-dried powder of J (manufactured by Maruzen Pharmaceutical Co., Ltd.) was dissolved in water to obtain a liquid composition.

(Examples 3 to 11)
A liquid composition was produced in the same manner as in Example 2, except that the content of each raw material component was as shown in Table 1.

(Comparative example 1)
A liquid composition was produced in the same manner as in Example 1, except that Bellflower was not used as a raw material.

(Comparative example 2)
A liquid composition was produced in the same manner as in Example 1, except that Scutellaria root was not used as a raw material.

(Comparative Example 3)
A liquid composition was obtained in the same manner as in Example 1 except that Scutellaria root and Bellflower were not used as raw materials. That is, the liquid composition of this comparative example is water.

(Comparative Example 4)
A liquid composition was produced in the same manner as in Example 2, except that Bellflower was not used as a raw material.

(Comparative Example 5)
A liquid composition was produced in the same manner as in Example 2, except that Scutellaria root was not used as a raw material.

(Comparative Example 6)
A liquid composition was produced in the same manner as in Example 2, except that Scutellaria root and Bellflower were not used as raw materials.

Table 1 summarizes the compositions and the like of the liquid compositions according to the above-described Examples and Comparative Examples. In Table 1, the content of Scutellaria root in the liquid composition is X _A [% by mass], the content of Bellflower in the liquid composition is X _B [% by mass], and the content of Rhubarb in the liquid composition is It was shown by _XC [mass %].

<<2>> Evaluation The following evaluations were performed using the liquid compositions according to the examples and the comparative examples.

<<2-1>> Biofilm formation inhibition test

Porphyromonas gingivalis (Porphyromonas gingivalis JCM12257) was pre-cultured in GAM medium (manufactured by Wako Pure Chemical Industries, Ltd.) at 37° C. for 24 hours to obtain a pre-culture liquid.

The obtained pre-cultured bacterial solution was added to a medium containing hemin-menadione so that the number of bacteria was 10 ⁷ CFU/mL to obtain a cultured bacterial solution. After that, 0.5 mL each of the culture solution was seeded in a 48-well plate.

Here, 0.5 mL of the liquid composition was added to a 48-well plate and anaerobically cultured at 37° C. for 24 hours.

After 24 hours, the 48-well plate was washed twice with phosphate-buffered saline (PBS) prepared with PBS(−) powder (manufactured by Nissui Pharmaceutical Co., Ltd.) according to the directions for use to remove floating bacteria.

A 0.1% by mass crystal violet (manufactured by Wako Pure Chemical Industries, Ltd.) solution was added thereto to dye the formed biofilm.

After that, the biofilm was washed with PBS, and crystal violet was extracted with ethanol. Next, the amount of biofilm was quantified with an absorbance meter and evaluated according to the following criteria. It can be said that the smaller the absorbance, the smaller the amount of biofilm, and the more the formation of periodontal bacterial plaque can be suppressed.

A: Absorbance less than 1.0.
B: Absorbance of 1.0 or more and less than 5.5.
C: Absorbance of 5.5 or more and less than 7.0.
D: Absorbance of 7.0 or more and less than 9.5.
E: Absorbance of 9.5 or more.

<<2-2>> Color tone

The absorbance of light having a wavelength of 286 nm was measured for the liquid compositions according to the examples and the comparative examples, and evaluated according to the following criteria. If the absorbance is high, the appearance of the liquid composition is inferior, and if the absorbance is low, the appearance is excellent.

A: Absorbance less than 25.0.
B: Absorbance of 25.0 or more.
These results are shown in Table 2. Table 2 also shows the concentration (content rate) of each component at the time of the above test.

As is clear from Table 2, the present invention gave excellent results, while the comparative examples did not give satisfactory results. More specifically, as is clear from Example 1 and Comparative Examples 1 and 2 in Table 2, even at concentrations where Scutellaria root and Bellflower alone are completely ineffective, their combined use yielded a remarkable effect. Moreover, as is clear from Example 2 and Comparative Examples 4 and 5, even at concentrations where two components, such as Scutellaria root and rhododendron and bellflower and rhododendron, are completely ineffective, a remarkable effect can be obtained by mixing the three components. was taken.

Further, a toothpaste as an oral composition was produced using the liquid composition according to Example 2 in the following manner. After that, the feeling of use was evaluated.

<Prescription A>
First, the liquid composition according to Example 2 was added to a predetermined amount of zeolite as a porous body.
Next, this mixture was dried to carry the crude drug extract in the pores of the porous body.

Thereafter, according to the following formulation (unit: % by mass), a toothpaste as an oral composition was produced by a conventional method.

Ougon: 0.01
Bellflower: 0.05
Zi-O: 0.4
Calcium carbonate: 30.0
Silicic anhydride: 5.0
Zeolite: 5.0
Sorbit liquid: 15.0
Concentrated glycerin: 10.0
Carboxymethylcellulose sodium: 1.0
Sodium lauryl sulfate: 0.5
Saccharin sodium: 0.05
Perfume: 1.0
Water: rest

<Prescription B>
First, the liquid composition according to Example 2 was mixed with the following mass % components. Thereafter, according to the following formulation (unit: % by mass), a toothpaste as an oral composition was produced by a conventional method.

Ougon: 0.01
Bellflower: 0.05
Zi-O: 0.4
Calcium carbonate: 30.0
Silicic anhydride: 5.0
Sorbit liquid: 15.0
Concentrated glycerin: 10.0
Carboxymethylcellulose sodium: 1.0
Sodium lauryl sulfate: 0.5
Saccharin sodium: 0.05
Perfume: 1.0
Water: rest

That is, the toothpaste of formulation B differs from the toothpaste of formulation A in that it does not contain zeolite as a porous material and has a higher water content.

An appropriate amount (about 1 g) of the two types of toothpaste (oral composition) obtained as described above was placed on a commercially available toothbrush by 15 adults and used, and the feeling of use was evaluated. I got it.

As a result, all 15 people answered that the prescription A toothpaste (oral composition) caused less discomfort such as bitterness compared to the use of the prescription B toothpaste (oral composition). did.

In addition, using the liquid compositions (compositions containing water) according to the above Examples and Comparative Examples, according to the following formulation (unit: % by mass), a mouthwash (mouthwash) as an oral composition was prepared by a conventional method. agent), denture cleanser and denture fixative.

<Mouthwash>
Ougon: 0.01
Bellflower: 0.05
Zi-O: 0.4
Denatured Alcohol No. 56: 5.0
Polyoxyethylene hydrogenated castor oil: 0.5
Concentrated glycerin: 5.0
Xylitol: 5.0
Cetylpyridinium chloride: 0.05
Dipotassium glycyrrhizinate: 0.05
Ethyl paraoxybenzoate: 0.05
Propyl paraoxybenzoate: 0.05
Citric acid: 0.03
Sodium citrate: 0.12
Perfume: 1.0
Water: rest

<Denture cleaner>
Ougon: 0.01
Bellflower: 0.05
Zi-O: 0.4
Silicic anhydride: 3.0
Hydrous silicic acid: 10.0
Polyethylene glycol 400: 5.0
Concentrated glycerin: 35.0
60% by mass sorbitol solution: 30.0
Sodium lauryl sulfate: 2.0
Carboxymethylcellulose sodium: 1.5
Perfume: 1.0
Sodium carbonate: Appropriate amount Water: Remainder

<Denture stabilizer>
Ougon: 0.01
Bellflower: 0.05
Zi-O: 0.4
Zeolite: 5.0
Concentrated glycerin: 30.0
Carboxymethylcellulose sodium: 3.0
Polyoxyethylene hydrogenated castor oil: 1.0
Cetylpyridinium chloride: 0.05
Perfume: 1.0
Sodium carbonate: Appropriate amount Water: Remainder

When these samples were evaluated in the same manner as described above, the same results as described above were obtained.

The oral composition of the present invention is characterized by containing Scutellaria root and Bellflower. Therefore, it has the effect of suppressing the formation of periodontal bacterial plaque, and the effect can be obtained with a lower dose than using a single crude drug. Therefore, the oral composition of the present invention has industrial applicability.

Claims (4)

A dentifrice containing scutellaria root, rhododendron and bellflower,
The content of the Scutellaria root in the dentifrice is 0.01% by mass or more and 0.5% by mass or less, and the content of the Bellflower in the dentifrice is 0.05% by mass or more and 2% by mass or less, A dentifrice characterized by containing 0.4% by mass or more and 2% by mass or less of said rhubarb in said dentifrice, and containing no cinnamon bark . When the content of Scutellaria root in the dentifrice is X _A [mass%], and the content of the rhubarb in the dentifrice is _{Xc [mass%], the relationship 4 ≤ X C /X A ≤ 120} The dentifrice according to claim 1, which satisfies 0.0005≦X _C /X _B ≦20000, where X _B [mass %] is the content of the bellflower in the dentifrice, and X _C [mass %] is the content of the rhubarb in the dentifrice. 3. The dentifrice according to claim 1 or 2, which satisfies the relationship of The dentifrice according to any one of claims 1 to 3 , wherein the content of the rhubarb in the dentifrice is higher than the content of the Scutellaria root in the dentifrice.