JP7205340B2 - bioadhesive applicator - Google Patents

Description

The present invention relates to bioadhesive applicators.

BACKGROUND ART As a bioadhesive applicator, there is a bioadhesive applicator comprising a gas chamber having a gas introduction part and a gas ejection part, and a plurality of liquid flow tubes passing through the internal space of the gas chamber. Each liquid flow pipe has an outlet located near the gas ejection portion. Such a bioadhesive applicator sprays and mixes the liquids discharged from the discharge ports of the plurality of liquid flow tubes, and applies them to the living tissue by urging them with the gas discharged from the gas discharge part. is configured to
In such a bioadhesive applicator, a coagulum of liquid leaking from the discharge port of the liquid flow tube may grow.

In Patent Document 1, a liquid flow pipe is compressed by the external pressure of the gas introduced into the gas chamber (nozzle body of the same document) and is contracted, and is provided with a pump portion (expansion/contraction portion of the same document) that is restored when the external pressure is reduced. is stated.
According to the technique disclosed in Patent Document 1, the pump portion recovers after the liquid discharge and the gas introduction are stopped, so that the liquid can be sucked from the discharge port side of the liquid flow pipe to the pump portion side. In addition, it is possible to suppress the occurrence of a phenomenon in which the solidified substance of the liquid that drips from the discharge port of the liquid flow pipe grows.

JP 2018-201726 A

However, according to the study of the inventors of the present application, the technique of Patent Document 1 still has room for improvement in terms of the structure for sucking the liquid from the discharge port side of the liquid flow pipe to the pump section side.

SUMMARY OF THE INVENTION The present invention has been made in view of the above-mentioned problems, and provides a bioadhesive applicator having a structure capable of sucking liquid from the discharge port side of the liquid flow tube to the pump section side more satisfactorily. is.

The present invention provides a gas chamber having a gas introduction portion into which gas is introduced and a gas ejection portion from which the gas is ejected;
a plurality of liquid flow pipes passing through the interior space of the gas chamber and having discharge ports arranged near the gas discharge portion;
with
A bioadhesive applicator that sprays and mixes liquids ejected from the ejection ports of the plurality of liquid flow tubes and applying them to living tissue by urging them with the gas ejected from the gas ejection part. and
A specific liquid distribution pipe, which is at least one liquid distribution pipe among the plurality of liquid distribution pipes, has a plurality of pump portions respectively configured by different parts in the axial direction of the specific liquid distribution pipe,
A portion of the specific liquid flow pipe located between the plurality of pump portions is a constricted portion having a diameter smaller than that of the pump portion,
Each of the plurality of pump parts is compressed by the gas pressure to reduce the internal volume while the gas is being introduced into the gas chamber, and is elastically restored when the introduction of the gas into the gas chamber is stopped. A bioadhesive applicator is provided.

According to the present invention, it is possible to more favorably suck the liquid from the discharge port side of the liquid flow pipe to the pump section side.

It is a figure which shows the whole structure of the bioadhesive applicator which concerns on 1st Embodiment. FIG. 2 is a plan cross-sectional view of the spray unit of the bioadhesive applicator according to the first embodiment (a cross-sectional view taken along line II-II in FIG. 1). Fig. 4 is a front view showing the tip of the spray unit of the bioadhesive applicator according to the first embodiment; 4 is a cross-sectional view taken along line IV-IV of FIG. 3; FIG. 5(a) and 5(b) are diagrams showing the specific liquid flow pipe of the bioadhesive applicator according to the first embodiment, of which FIG. FIG. 5(b) is a plan view showing the entirety of the first liquid flow pipe main body that constitutes the specific liquid flow pipe. 6(a) and 6(b) are cross-sectional views taken along line VI-VI in FIG. 5(a), of which FIG. (b) shows a state in which the pump section is restored. FIG. 11 is an enlarged cross-sectional view of the vicinity of the pump portion of the specific liquid flow tube of the bioadhesive applicator according to the second embodiment; FIG. 11 is an enlarged cross-sectional view of the vicinity of the pump portion of the specific liquid flow tube of the bioadhesive applicator according to the third embodiment; 9(a) and 9(b) are enlarged views showing the vicinity of the pump portion of the specific liquid flow tube of the bioadhesive applicator according to the fourth embodiment, of which FIG. 9(a) is a cross-sectional view; FIG. 9(b) is a plan view. FIGS. 10(a) and 10(b) are diagrams showing the specific liquid flow tube of the bioadhesive applicator according to the modification of the fourth embodiment, and FIG. 10(a) shows the specific liquid flow tube. Fig. 10(b) is an enlarged cross-sectional view showing the periphery of the pump section;

Hereinafter, embodiments of the bioadhesive applicator of the present invention will be described based on the drawings.
The embodiments described below are merely examples for facilitating understanding of the present invention, and do not limit the present invention. That is, the shape, size, arrangement, etc. of the members described below can be changed and improved without departing from the scope of the present invention.
Moreover, in all the drawings, the same constituent elements are denoted by the same reference numerals, and overlapping descriptions are omitted as appropriate.
Hereinafter, the side of the bioadhesive applicator to which the liquid is discharged will be referred to as the front end side or front side, and the opposite side will be referred to as the base end side or rear side. In addition, a horizontal direction perpendicular to the front-rear direction is referred to as a lateral direction, and among the lateral directions, the left side when the bioadhesive applicator is viewed from the front side is referred to as the left direction, and the right side is referred to as the right direction. . However, these orientations are for convenience only and do not limit the orientation during manufacture or use of the bioadhesive applicator.
Further, unless otherwise specified, the shape of each part of each liquid circulation pipe is described in the natural state, not in the compressed state.

[First embodiment]
First, the first embodiment will be described with reference to FIGS. 1 to 6B.
The left side in FIG. 2 is the front side, and the right side in FIG. 2 is the rear side. FIG. 3 shows the tip of the spray unit 10 extracted from the structure of the spray unit 10 viewed from the left in FIG. FIG. 5(a) is a cross-sectional view along the axis of the first liquid flow pipe 31. FIG.

As shown in any one of FIGS. 1 to 6B, the bioadhesive applicator 100 according to the present embodiment includes a gas introduction portion 22 (FIG. 1) into which gas is introduced, and a gas ejection portion for ejecting gas. a gas chamber 20 (FIGS. 1, 2) having a portion 24 (FIGS. 1, 3, 4) and a gas ejection portion 24 passing through an internal space 21 (FIG. 2) of the gas chamber 20; A plurality of liquid flow pipes (for example, as shown in FIG. 2, a first liquid flow pipe 31 and a second liquid flow pipe 32, which are two liquid flow pipe) and The bioadhesive applicator 100 includes liquids 38 and 39 (FIGS. 3, 4, 4 and 5) ejected from ejection openings 31a and 32a of a plurality of liquid circulation tubes (first liquid circulation tube 31, second liquid circulation tube 32). 6(a) and 6(b)) is energized by the gas jetted from the gas jetting part 24 to spray, mix, and apply to the living tissue.
A specific liquid distribution pipe (first liquid distribution pipe 31 in this embodiment), which is at least one liquid distribution pipe among a plurality of liquid distribution pipes (first liquid distribution pipe 31, second liquid distribution pipe 32), It has a plurality of pump portions 40 (FIGS. 2, 5(a), 5(b)) each configured by a different portion in the axial direction of the specific liquid flow pipe. In the case of this embodiment, the first liquid flow pipe 31 has, for example, two pump sections 40 , a first pump section 41 and a second pump section 42 .
In addition, in a specific liquid distribution pipe (first liquid distribution pipe 31), a portion located between the plurality of pump portions 40 is a constricted portion 37 (FIG. 5A, FIG. 5(b)).
The plurality of pump parts 40 are configured to be compressed by the gas pressure to reduce the internal volume while the gas is being introduced into the gas chamber 20, and to elastically restore when the introduction of the gas into the gas chamber 20 is stopped. It is

According to this embodiment, since the specific liquid flow pipe (first liquid flow pipe 31) has the pump portion 40, the introduction of the gas into the gas chamber 20 is stopped and the pump portion 40 is compressed. In the restoration process, the liquid 38 can be sucked from the discharge port 31a side of the specific liquid flow pipe to the pump section 40 side. Therefore, it is possible to suppress the liquid 38 from dripping from the ejection port 31a, thereby suppressing the phenomenon that the liquid 38 dripping from the ejection port 31a grows.
Moreover, in the case of the present embodiment, the specific liquid circulation pipe has a plurality of pump parts 40 each configured by different parts in the axial direction of the specific liquid circulation pipe. Therefore, the liquid 38 can be sucked from the discharge port 31a side to the pump section 40 side with a stronger suction force than when there is only one pump section 40 . Therefore, it is possible to more reliably prevent the liquid 38 from dripping from the ejection port 31a and the growth of the solidified substance of the liquid 38 dripping from the ejection port 31a.
As a result, when the gas is introduced again into the gas chamber 20 and the liquids 38 and 39 are discharged from the respective liquid distribution tubes, and the sprayed and mixed liquids 38 and 39 are applied to the biological tissue, the discharge of the specific liquid distribution tube is suppressed. It is possible to smoothly discharge the liquid 38 from the outlet 31a.

As shown in FIG. 1 , the bioadhesive applicator 100 includes at least a spray unit 10 .
As shown in FIG. 2, the spray unit 10 includes a gas chamber 20 and a plurality of liquid flow pipes (in this embodiment, a first liquid flow pipe 31 and a second liquid flow pipe 32) inserted through the gas chamber 20. ) and
In the case of this embodiment, the bioadhesive applicator 100 includes, in addition to the spray unit 10, for example, two injection tools 80, a plunger holder 83, an air filter unit 85, a regulator 90, and an air supply tube 91. , is equipped with

Each injection tool 80 has a syringe 81 and a plunger 82 inserted into the syringe 81 .
One injection tool 80 is connected to the spray unit 10 so that the tip of the syringe 81 of the injection tool 80 communicates with the base end of the first liquid flow pipe 31 . The other injection tool 80 is connected to the spray unit 10 so that the distal end of the syringe 81 of the injection tool 80 communicates with the proximal end of the second liquid flow pipe 32 .
One injection tool 80 is used, for example, to inject the highly viscous liquid 38 containing fibrinogen or the like, which is likely to solidify, into the first liquid flow pipe 31 .
The other injector 80 is used to inject a liquid 39 containing thrombin or the like into the second liquid flow tube 32, for example.
A plunger holder 83 is used to hold the proximal ends of the plungers 82 of the two injection tools 80 . The operator using the bioadhesive applicator 100 holds the proximal ends of the two plungers 82 using the plunger holder 83 and pushes the two plungers 82 into the corresponding syringes 81, respectively, thereby holding the two plungers 82 together. can be pushed into each syringe 81 synchronously with each other.
By pushing the plunger 82 of one injection tool 80 into the syringe 81 , the liquid 38 is injected into the first liquid circulation pipe 31 and discharged from the discharge port 31 a at the tip of the first liquid circulation pipe 31 .
By pushing the plunger 82 of the other injection tool 80 into the syringe 81 , the liquid 39 is injected into the second liquid flow pipe 32 and discharged from the discharge port 32 a at the tip of the second liquid flow pipe 32 .

The downstream end of the air filter unit 85 is connected to the base end (upstream end) of the gas introduction section 22 of the gas chamber 20 . The air filter unit 85 has therein an air filter (not shown) that removes impurities from the gas supplied from the gas supply source. The air filter unit 85 has a connecting portion 85 a to which the air supply tube 91 is connected at the upstream end of the air filter unit 85 .
The air supply tube 91 is a flexible tube. A first connector 92a such as a female connector is provided at the proximal end of the air supply tube 91, and a second connector 92b such as a male connector is provided at the distal end of the air supply tube 91. As shown in FIG.
The first connector 92 a is connected to the gas lead-out end of the regulator 90 . The second connector 92b is connected to the connecting portion 85a of the air filter unit 85. As shown in FIG. As a result, the regulator 90 and the air filter unit 85 are connected to each other via the regulator 90 .
A gas supply source (not shown) such as a gas cylinder is connected to the gas introduction end of the regulator 90 .
The gas supplied from the gas supply source to the regulator 90 is decompressed by the regulator 90 to a pressure suitable for use of the bioadhesive applicator 100, passes through the air supply tube 91 and the air filter unit 85 in this order, and enters the gas introduction section. 22 into the internal space 21 of the gas chamber 20 .
The gas introduced into the internal space 21 is ejected from a gas ejection portion 24 formed at the tip of the gas chamber 20 . The gas ejection part 24 is composed of, for example, one or more pores, and the gas introduced into the internal space 21 is vigorously ejected from the gas ejection part 24 .
In addition, while the gas is being introduced from the gas introduction part 22 into the gas chamber 20, the internal space 21 is maintained at a pressure higher than the atmospheric pressure.

When using the bioadhesive applicator 100 , the operator operates the plunger holder 83 to push the syringes 81 of the two injection tools 80 into the respective plungers 82 while introducing gas into the gas chamber 20 .
As a result, the liquids 38 and 39 can be ejected from the ejection ports 31a and 32a of the first liquid circulation pipe 31 and the second liquid circulation pipe 32 while the gas is ejected from the gas ejection portion 24 .
Therefore, by urging the liquids 38 and 39 ejected from the ejection ports 31a and 32a with the gas ejected from the gas ejection portion 24, the liquids 38 and 39 can be sprayed and mixed and applied to the living tissue.

As shown in FIG. 2, the spray unit 10 includes, for example, a chamber main body 50, a proximal side member 60, a distal side member 70, a first liquid flow pipe main body 33, and a second liquid flow pipe main body 34, which will be described below. configured with.
Of these, the gas chamber 20 is mainly composed of the chamber main body 50 and the base end member 60, and the first liquid flow pipe 31 is mainly composed of the first liquid flow pipe main body 33 and part of the distal end member 70. The second liquid flow pipe 32 is mainly composed of the second liquid flow pipe main body 34 and another portion of the distal end member 70 .

As shown in FIGS. 1 and 2, the chamber main body 50 is a hollow member, and is formed in, for example, a bell shape that is vertically flat and tapered forward. The internal space of the chamber main body 50 constitutes the internal space 21 .
The chamber main body 50 includes the gas introduction section 22 . The gas introduction part 22 is formed in a tubular shape, and protrudes upward (for example, obliquely upward and rearward) from the top surface of the chamber main body 50, for example.
The chamber main body 50 is formed, for example, left-right symmetrical, and the portion of the chamber main body 50 other than the gas introduction portion 22 is also formed symmetrically vertically.
The distal end portion 52 of the chamber body 50 has two insertion holes 52a (FIGS. 3 and 4) arranged side by side. Each insertion hole 52a penetrates the front end portion 52 in the front-rear direction, and allows the internal space of the chamber body 50 (that is, the internal space 21) and the space in front of the chamber body 50 to communicate with each other.
A proximal end portion 51 of the chamber main body 50 has a proximal opening 51a that opens rearward.

As shown in FIG. 2, the proximal end member 60 includes, for example, a plate-like body portion 61, a pair of left and right syringe mounting portions 62a and 62b to which a syringe 81 of the injection tool 80 is mounted (connected), and a pair of left and right liquid flow pipe mounting portions 63a and 63b to which the base end portions 33a and 34a of the first liquid flow pipe main body 33 and the second liquid flow pipe main body 34 are respectively mounted; have.
The body portion 61 is formed, for example, in the shape of a flat plate elongated in the left-right direction, and the plate surface of the body portion 61 faces the front-rear direction. The body portion 61 is attached to the base end portion 51 so as to close the base end opening 51 a of the chamber body 50 .
The internal space 21 is defined by the inner peripheral surface of the chamber main body 50 and the front surface of the main body portion 61 .
The left syringe mounting portion 62 a protrudes rearward from the left end portion of the main body portion 61 , and the right syringe mounting portion 62 b protrudes rearward from the right end portion of the main body portion 61 .
The left liquid flow tube mounting portion 63 a protrudes forward from the left end of the main body 61 , and the right liquid flow pipe mounting portion 63 b protrudes forward from the right end of the main body 61 . Each of the liquid flow tube mounting portions 63a and 63b is arranged in the internal space 21. As shown in FIG.
The syringe mounting portion 62a and the liquid flow tube mounting portion 63a are coaxially arranged with the left end portion of the main body portion 61 interposed therebetween. are arranged coaxially with each other with the right end of the
A pair of left and right through-holes 64a and 64b are formed in the base end member 60. As shown in FIG.
The left through-hole 64a extends through the base end member 60 from the rear end of the syringe mounting portion 62a to the front end of the liquid flow tube mounting portion 63a, and the right through-hole 64b is the syringe mounting portion. It extends through the base end member 60 in the front-rear direction from the rear end of 62b to the front end of the liquid flow tube mounting portion 63b.
The partition wall-constituting portion 65 is a plate-like portion extending forward from the central portion in the horizontal direction of the front surface of the main body portion 61, and the plate surface of the partition wall-constituting portion 65 faces the left-right direction. .
The partition wall-constituting portion 65 constitutes the partition wall portion 25 that partitions the internal space 21 into the left and right.
The gas introduction portion 22 is arranged above the partition wall portion 25 (partition wall forming portion 65). The downstream end of the gas introducing portion 22 straddles the partition wall forming portion 65 from left to right. Therefore, the gas introduced into the internal space 21 from the gas introduction part 22 is distributed by the partition wall part 25 into the left half region and the right half region of the internal space 21 .

As shown in FIG. 2, the tip side member 70 includes, for example, a first discharge pipe 71 forming the tip of the first liquid flow pipe 31 and the tip of the second liquid flow pipe 32. It has a second discharge pipe 72 and a connection portion 73 that connects the first discharge pipe 71 and the second discharge pipe 72 to each other.
The first discharge pipe 71 and the second discharge pipe 72 are each formed in a circular tubular shape, are spaced apart from each other, and are arranged in parallel with each other.
The connecting portion 73 connects, for example, the axial center portion of the first discharge pipe 71 and the axial center portion of the second discharge pipe 72 to each other.
For this reason, for example, the planar shape of the tip side member 70 is H-shaped.

A portion of the first discharge pipe 71 that protrudes to the proximal side from the connecting portion 73 is a holding portion 71a that holds the distal end portion 33b of the first liquid flow pipe main body 33. The projecting portion is the projecting portion 71b.
A portion of the second discharge pipe 72 that protrudes to the proximal side from the connecting portion 73 is a holding portion 72a that holds the distal end portion 34b of the second liquid flow pipe main body 34, and is located to the distal side from the connecting portion 73. The projecting portion is the projecting portion 72b.
The opening at the tip of the first discharge pipe 71, that is, the opening at the tip of the projecting portion 71b constitutes the discharge port 31a. The opening at the tip of the second discharge pipe 72, that is, the opening at the tip of the projecting portion 72b constitutes the discharge port 32a.

As described above, the distal end portion 52 of the chamber body 50 has two insertion holes 52a arranged side by side.
The projecting portions 71 b and 72 b of the distal end side member 70 are inserted into the left and right insertion holes 52 a from behind the distal end portion 52 . That is, the protrusion 71b is inserted into the left insertion hole 52a, and the protrusion 72b is inserted into the right insertion hole 52a.
Each projecting portion 71b, 72b projects slightly forward from the front surface of the distal end portion 52. As shown in FIG.
The connecting portion 73 is sandwiched, for example, between the rear surface of the tip portion 52 and the front end surface of the partition wall forming portion 65 . This restricts the rearward displacement of the distal end side member 70 relative to the distal end portion 52 (that is, the protrusions 71b and 72b are prevented from coming out of the insertion holes 52a rearward).
The axial direction of each of the first discharge pipe 71 and the second discharge pipe 72 extends in the front-rear direction.

As shown in FIG. 3, in the case of the present embodiment, the gas chamber 20 includes a left gas ejection part 24 arranged near the ejection port 31a and a right gas ejection part 24 arranged near the ejection port 32a. a portion 24;
The left gas ejection portion 24 is formed by a portion located around the projecting portion 71b at the opening at the tip of the left insertion hole 52a.
The right gas ejection portion 24 is formed by a portion located around the projecting portion 72b at the opening at the tip of the right insertion hole 52a.

As shown in FIG. 3, a plurality of (for example, four) fixing ribs 52b are formed on the inner peripheral surface of each insertion hole 52a and protrude radially inward of each insertion hole 52a. The plurality of fixing ribs 52b of each insertion hole 52a are arranged at predetermined intervals (for example, equiangular intervals) in the circumferential direction of each insertion hole 52a.
The protrusion 71b of the first discharge pipe 71 is press-fitted into the left insertion hole 52a, and the fixed ribs 52b of the left insertion hole 52a are pressed against the outer peripheral surface of the protrusion 71b.
The protrusion 72b of the second discharge pipe 72 is press-fitted into the right insertion hole 52a, and the fixed ribs 52b of the right insertion hole 52a are pressed against the outer peripheral surface of the protrusion 72b.
Therefore, the protrusion 71b is fixed to the left insertion hole 52a, and the protrusion 72b is fixed to the right insertion hole 52a.

The gas chamber 20 has a gas flow passage 23 (FIG. 4) that guides the gas introduced into the internal space 21 to each gas ejection portion 24 .
In this embodiment, the gas chamber 20 has a left gas flow passage 23 that guides gas to the left gas ejection portion 24 and a right gas flow passage 23 that guides gas to the right gas ejection portion 24 .
The gap between the outer peripheral surface of the protrusion 71b and the inner peripheral surface of the left insertion hole 52a constitutes the left gas flow passage 23, and the outer peripheral surface of the protrusion 72b and the inner peripheral surface of the left insertion hole 52a are formed. The gap between the surfaces constitutes the gas flow passage 23 on the right side.
In other words, each gas flow passage 23 is an aggregate of a plurality of (for example, four in the present embodiment) gas flow passages partitioned by the fixed ribs 52b.
An opening at the tip of the gas flow passage 23 is the gas ejection portion 24 . That is, each of the left and right gas ejection portions 24 is an assembly of a plurality of (for example, four in the present embodiment) openings.
As described above, the protrusions 71b and 72b slightly protrude forward from the insertion holes 52a, so that the gas ejection sections 24 are arranged in the vicinity of the discharge ports 31a and 31b. Therefore, the liquids 38 and 39 ejected from the ejection ports 31a and 32a can be atomized and mixed by the gas ejected from the gas ejection portions 24 to the outside.

Note that the connecting portion 73 covers, for example, the side surface of the first discharge pipe 71 opposite to the second discharge pipe 72 side, and the side surface of the second discharge pipe 72 opposite to the first discharge pipe 71 side. Covering the sides of the side.
Thereby, a narrow gap is formed between the connecting portion 73 and the inner peripheral surface of the chamber main body 50 in the vicinity of the tip portion 52 .
The gas in the internal space 21 is guided to the gas flow passage 23 through these gaps.

Materials constituting the gas chamber 20, that is, materials constituting the chamber main body 50, the proximal side member 60 and the distal side member 70 are not particularly limited, but for example, the chamber main body 50, the proximal side member 60 and the distal side member 70 is made of resin or the like, for example.
Preferably, the volume of gas chamber 20 does not substantially vary with the gas pressure within interior space 21 . Therefore, it is preferable that the chamber body 50, the proximal member 60, and the distal member 70 are made of hard resin.

As shown in FIG. 2, each of the first liquid flow pipe main body 33 and the second liquid flow pipe main body 34 is a tubular member.
The base end portion 33a of the first liquid flow pipe main body 33 is mounted on the liquid flow pipe mounting portion 63a (held by the liquid flow pipe mounting portion 63a), for example, by being fitted onto the liquid flow pipe mounting portion 63a. . The tip portion 33b of the first liquid flow pipe main body 33 is attached to (held by the holding portion 71a) the holding portion 71a by, for example, being externally inserted into the holding portion 71a. The opening at the proximal end of the syringe mounting portion 62a and the discharge port 31a at the distal end of the first discharge pipe 71 communicate with each other through the through hole 64a, the first liquid flow pipe main body 33, and the first discharge pipe 71. ing. The first liquid flow pipe 31 is composed of the first liquid flow pipe main body 33 , the first discharge pipe 71 , and the through hole 64 a of the proximal end member 60 .
Similarly, the base end portion 34a of the second liquid flow pipe main body 34 is attached to the liquid flow pipe mounting portion 63b (held by the liquid flow pipe mounting portion 63b) by, for example, being externally inserted into the liquid flow pipe mounting portion 63b. It is The tip portion 34b of the second liquid flow pipe main body 34 is, for example, attached to the holding portion 72a (held by the holding portion 72a) by being externally inserted into the holding portion 72a. The opening at the proximal end of the syringe mounting portion 62b and the discharge port 32a at the distal end of the second discharge pipe 72 communicate with each other via the through hole 64b, the second liquid flow pipe main body 34, and the second discharge pipe 72. ing. The second liquid flow pipe 32 is composed of the second liquid flow pipe body 34 , the second discharge pipe 72 , and the through hole 64 b of the base end member 60 .
The holding portion 71a, the first liquid flow pipe main body 33, and the liquid flow pipe mounting portion 63a are arranged in one (left) region of the internal space 21 partitioned by the partition wall portion 25. The liquid flow pipe main body 34 and the liquid flow pipe mounting portion 63 b are arranged in the other (right) region of the internal space 21 partitioned by the partition wall portion 25 .

As shown in FIG. 2 , the first liquid flow pipe main body 33 has a plurality of pump parts 40 . More specifically, in this embodiment, the first liquid flow pipe main body 33 has two pump sections 40 , a first pump section 41 and a second pump section 42 . The second pump section 42 is arranged on the upstream side (base end side) of the first liquid flow pipe 31 (specific liquid flow pipe) relative to the first pump section 41 .
Each pump portion 40 is a portion that has a greater compression ratio (ratio of inner volume reduction) due to external pressure (gas pressure in the internal space 21 ) than portions other than the pump portion 40 in the first liquid flow pipe 31 .
Each pump section 40 has, for example, an inner diameter and an outer diameter (average value of inner diameter and average value of outer diameter) larger than portions other than the pump section 40 in the first liquid flow pipe 31 .
Each of the first liquid flow pipe main body 33 and the second liquid flow pipe main body 34 is integrally formed of, for example, a flexible material such as elastomer (for example, silicone rubber).
In the case of this embodiment, the first liquid circulation pipe main body 33 (the first liquid circulation pipe 31 ) is locally formed thin in each pump section 40 . Therefore, the first liquid flow pipe main body 33 is partially flexible in each pump section 40 (although the entirety is integrally molded from the same material). However, the present invention is not limited to this example, and the portion forming each pump portion 40 in the first liquid flow pipe 31 may be locally made of a softer material than the other portions.

As shown in FIGS. 5A and 5B, the first pump portion 41 has, for example, a cylindrical portion 45 and a tapered portion 46 connected to the distal end side of the cylindrical portion 45 . Further, the second pump portion 42 has, for example, a cylindrical portion 45 and a tapered portion 46 connected to the base end side of the cylindrical portion 45 .

The cylindrical portion 45 of the first pump portion 41 has, for example, a cylindrical main portion 45a and pump portion ribs 45b formed on the outer peripheral surface of the main portion 45a. That is, a pump portion rib 45 b is formed on the outer peripheral surface of the first pump portion 41 .
The inner and outer diameters of the main portion 45a are constant, and therefore the thickness of the main portion 45a is constant.
The number of pump portion ribs 45b included in the cylindrical portion 45 of the first pump portion 41 is not particularly limited, and may be one or more.
In the case of this embodiment, the cylindrical portion 45 of the first pump portion 41 has, for example, a plurality of (eg, three) pump portion ribs 45b that are separated from each other in the axial direction of the first pump portion 41 .
Each pump portion rib 45 b may extend in the circumferential direction of the pump portion 40 (first pump portion 41 ), and does not necessarily have to rotate 360 degrees in the circumferential direction of the pump portion 40 . Further, the pump portion ribs 45b may be aggregates of a plurality of ribs that are intermittently arranged in the circumferential direction of the pump portion 40 .
In the case of this embodiment, each pump section rib 45b rotates 360 degrees in the circumferential direction of the pump section 40 .
The tapered portion 46 of the first pump portion 41 has, for example, an inner diameter that tapers toward the tip side, an outer diameter that tapers toward the tip side, and The thickness of the tapered portion 46 gradually increases toward the tip side.

The cylindrical portion 45 of the second pump portion 42 is formed, for example, in the same shape and dimensions as the cylindrical portion 45 of the first pump portion 41 . That is, a pump portion rib 45 b is also formed on the outer peripheral surface of the second pump portion 42 .
The inner diameter of the tapered portion 46 of the second pump portion 42 is, for example, tapered toward the base end side. The outer diameter of the tapered portion 46 of the second pump portion 42 is tapered toward the base end side at the front portion (distal side portion) of the tapered portion 46 . (Base end portion) is constant. For example, the thickness of the tapered portion 46 of the second pump portion 42 is constant at the front portion of the tapered portion 46, and gradually increases toward the proximal side at the rear portion of the tapered portion 46. ing.

In the first liquid flow pipe main body 33 , the portion other than the pump portion 40 has a smaller compression ratio (the rate at which the internal volume is reduced) due to the external pressure (the gas pressure in the internal space 21 ) than the pump portion 40 .
The first liquid flow pipe main body 33 includes, as portions other than the pump portion 40, a non-pump portion 35 located on the distal side of the first pump portion 41 and a non-pump portion located on the proximal side of the second pump portion 42. and a constricted portion 37 located at the boundary between the first pump portion 41 and the second pump portion 42 (between the first pump portion 41 and the second pump portion 42).

As shown in FIGS. 5(a) and 5(b), in the first liquid flow pipe 31, the inner periphery of the portion (constricted portion 37) located at the boundary between the first pump portion 41 and the second pump portion 42 A ring-shaped boundary rib 37b is formed on the surface.
That is, the boundary rib 37b protrudes radially inward at a portion located on the boundary between the first pump portion 41 and the second pump portion 42 .
As a result, the inner diameter of the first liquid flow pipe 31 is locally reduced at the constricted portion 37 . That is, the constricted portion 37 has a smaller diameter than the pump portion 40 .
In the case of the present embodiment, the inner diameter of the constricted portion 37 is smaller than the inner diameter of the end on the constricted portion 37 side of each of the two pump portions 40 that are adjacent to each other with the constricted portion 37 interposed therebetween. That is, the inner diameter of the constricted portion 37 is smaller than the inner diameter at the proximal end of the cylindrical portion 45 of the first pump portion 41, and the inner diameter of the constricted portion 37 is smaller than the inner diameter at the distal end of the cylindrical portion 45 of the second pump portion 42. is small.
Note that the boundary rib 37b only needs to extend in the circumferential direction of the first liquid flow pipe 31 and does not necessarily have to rotate 360 degrees in the circumferential direction of the first liquid flow pipe 31 . Also, the boundary rib 37b may be an assembly of a plurality of ribs intermittently arranged in the circumferential direction of the first liquid flow pipe 31. As shown in FIG.
In the case of this embodiment, the boundary rib 37b rotates 360 degrees in the circumferential direction of the first liquid flow pipe 31 .

The constricted portion 37 includes a cylindrical main portion 37a and boundary ribs 37b protruding radially inward from the main portion 37a.
In the case of this embodiment, the outer diameter of the main portion 45a of the cylindrical portion 45 of the first pump portion 41, the outer diameter of the main portion 37a of the constricted portion 37, and the main portion 45a of the cylindrical portion 45 of the second pump portion 42 are The outer diameters are equal to each other.
The inner diameter of the main portion 45a of the cylindrical portion 45 of the first pump portion 41, the inner diameter of the main portion 37a of the constricted portion 37, and the inner diameter of the main portion 45a of the cylindrical portion 45 of the second pump portion 42 are all equal. .
It should be noted that the inner peripheral surface of the main portion 37a that defines the inner diameter of the main portion 37a does not exist as an entity, and the inner peripheral surface of the imaginary constricted portion 37 when the boundary ribs 37b are removed from the constricted portion 37 is It is the surface.
In other words, the boundary ribs 37b are arranged radially of the first and second pump portions 41 and 42 relative to the inner peripheral surfaces of the main portions 45a of the cylindrical portions 45 of the first and second pump portions 41 and 42, respectively. This is the part that protrudes inward.
Therefore, as shown in FIG. 5A, the protrusion height (protrusion length) H2 of the boundary rib 37b is determined by is the protrusion height of the boundary rib 37b.
On the other hand, the protrusion height of the pump portion ribs 45 b of the first pump portion 41 is the protrusion height of the pump portion ribs 45 b from the outer peripheral surface of the main portion 45 a of the cylindrical portion 45 of the first pump portion 41 . Similarly, the protrusion height of the pump portion ribs 45 b of the second pump portion 42 is the protrusion height of the pump portion ribs 45 b from the outer peripheral surface of the main portion 45 a of the cylindrical portion 45 of the second pump portion 42 . In the case of this embodiment, the protrusion height of the pump portion rib 45b of the first pump portion 41 and the protrusion height of the pump portion rib 45b of the second pump portion 42 are equal to each other, and both are H1 shown in FIG. is.

Here, the protrusion height H1 of the pump portion rib 45b is smaller than the protrusion height H2 of the boundary rib 37b.
In this embodiment, an example in which the pump portion ribs 45b are formed on the outer peripheral surface of the pump portion 40 will be described, but the present invention is not limited to this example, and the pump portion ribs 45b are formed on the inner peripheral surface of the pump portion 40. may be formed. That is, the pump portion ribs 45b may be formed on the inner peripheral surface of the main portion 45a. Also, the pump portion ribs 45b may be formed on both the outer peripheral surface and the inner peripheral surface of the pump portion 40 .
Further, in the case of the present embodiment, an example in which each of the plurality of pump portions 40 (for example, both the first pump portion 41 and the second pump portion 42) has the pump portion rib 45b will be described, but the present invention At least one or more of the plurality of pump portions 40 may have the pump portion ribs 45b without being limited to the example.
Thus, the pump portion rib 45b having a lower height (smaller protrusion height) than the boundary rib 37b is formed on the outer peripheral surface or the inner peripheral surface of at least one of the first pump portion 41 and the second pump portion 42. It is

Constricted portion 37 is reinforced by boundary ribs 37b (which are taller than pump portion ribs 45b). Therefore, the constricted portion 37 has a smaller compression ratio due to external pressure (gas pressure in the internal space 21 ) than the pump portion 40 .
In the case of this embodiment, the dimension of the boundary rib 37b in the axial direction of the first liquid flow pipe body 33 is larger than the dimension of the pump portion rib 45b in the axial direction of the first liquid flow pipe body 33 . Therefore, the constricted portion 37 is more strongly reinforced by the boundary ribs 37b.

The non-pump portion 35 located on the distal end side of the first pump portion 41 includes, for example, a straight tubular portion 35a connected to the distal end side of the tapered portion 46 of the first pump portion 41 and a straight tubular portion 35a. and a tip portion 35b connected to the tip side.
The non-pump portion 35 is, for example, formed to have a constant inner diameter over the entire non-pump portion 35 .
The straight pipe portion 35a is formed to have a constant outer diameter over its entirety.
The inner and outer diameters of the straight pipe portion 35 a are equal to the inner and outer diameters at the tip of the tapered portion 46 of the first pump portion 41 .
The outer diameter of the proximal end of the distal end portion 35b is equal to the outer diameter of the distal end of the straight tube portion 35a.
The outer diameter of the tip portion 35b tapers toward the tip side at the rear portion (base end side portion) of the tip portion 35b, and the front portion (tip side portion) of the tip portion 35b has an outer diameter of is constant.

The non-pump portion 36 located on the proximal end side of the second pump portion 42 includes, for example, a straight pipe portion 36a connected to the proximal end side of the tapered portion 46 of the second pump portion 42, and a straight pipe portion 36a. and a proximal end portion 36b connected to the proximal end side of 36a.
The non-pump portion 36 is, for example, formed with a constant inner diameter over the entire non-pump portion 36 .
The straight pipe portion 36a is formed to have a uniform outer diameter throughout.
The inner and outer diameters of the straight pipe portion 36 a are equal to the inner and outer diameters of the tapered portion 46 of the second pump portion 42 at the proximal end.
The outer diameter of the base end portion 36b is equal to the outer diameter of the straight pipe portion 36a at the rear portion (base end portion) of the base end portion 36b, and , is relatively small.

Here, as described above, the holding portion 71a is inserted into the tip portion 33b of the first liquid flow pipe main body 33, and the tip portion 33b is held by the holding portion 71a.
Similarly, a liquid flow pipe mounting portion 63a is inserted into the base end portion 33a of the first liquid flow pipe main body 33, and the base end portion 33a is held by the liquid flow pipe mounting portion 63a.
The tip portion 33b includes at least the tip portion of the tip portion 35b, and may include the entire tip portion 35b and the tip portion of the straight tube portion 35a.
The base end portion 33a includes at least the base end portion of the base end portion 36b, and may include the entire base end portion 36b and the base end portion of the straight tube portion 36a.
Since the distal end portion 33b and the proximal end portion 33a are held by the holding portion 71a and the liquid flow tube mounting portion 63a, respectively, they are not substantially compressed by external pressure (gas pressure in the internal space 21).
That is, even if the distal end portion 33b is formed thinner than the straight pipe portion 35a (or thinner than the portion of the straight pipe portion 35a excluding the portion forming the distal end portion 33b), it does not function as the pump portion 40. , but not the pump unit 40 . Similarly, even if the base end portion 33a is formed thinner than the straight pipe portion 36a (or thinner than the portion of the straight pipe portion 36a excluding the portion forming the base end portion 33a), the pump portion 40 is It is not the pump part 40 because it does not function.
In other words, the pump portion 40 is different from the portions (the distal end portion 33b and the proximal end portion 33a) of the first liquid flow pipe main body 33 that are directly held by other members.
In the case of the present embodiment, the pump portion 40 is a portion other than the pump portion 40 in the first liquid flow pipe main body 33 and is neither the distal end portion 33b nor the proximal end portion 33a. It is formed to be relatively thin (small average thickness).

In this embodiment, for example, the inner diameter of the straight pipe portion 35a is smaller than the inner diameter of the straight pipe portion 36a, and the outer diameter of the straight pipe portion 35a is smaller than the outer diameter of the straight pipe portion 36a.
Further, the outer diameter of the tip portion 35b is smaller than the outer diameter of the straight tube portion 35a.
Therefore, as shown in FIG. 2, a sufficient gap can be secured between the outer peripheral surface of the tip portion 33b and the inner peripheral surface of the chamber main body 50, so that the gas in the internal space 21 can flow through the gas flow passage 23. It is possible to smoothly jet from the gas jetting portion 24 through the .

It is preferable that the plurality of pump parts 40 be arranged in the tip side portion of the first liquid flow pipe main body 33 . By doing so, the liquid 38 can be more preferably sucked from the discharge port 31a side of the specific liquid flow pipe to the pump section 40 side. In the case of this embodiment, the tip-side half of the first liquid flow pipe main body 33 includes the entire first pump section 41 and at least the front end section of the second pump section 42 .

The second liquid flow pipe main body 34 is, for example, entirely formed in a straight tubular shape (the outer diameter and the inner diameter of the whole are substantially constant).
The first liquid flow pipe main body 33 (excluding the plurality of pump portions 40) is formed thicker than the second liquid flow pipe main body 34, for example. For example, the outer diameter of the second liquid flow pipe main body 34 is smaller than the outer diameter of the first liquid flow pipe main body 33, and the inner diameter of the second liquid flow pipe main body 34 is larger than the inner diameter of the first liquid flow pipe main body 33. small.

Next, the operation will be explained.

When using the bioadhesive applicator 100 , the air filter unit 85 is connected to the gas introduction section 22 , the second connector 92 b of the air supply tube 91 is connected to the connection section 85 a , and the first connector 92 a is connected to the regulator 90 . , the regulator 90 is connected to a gas supply, such as a gas cylinder.
Also, the tip of the syringe 81 of one injection device 80 is connected to the syringe mounting portion 62a of the spray unit 10, and the tip of the syringe 81 of the other injection device 80 is connected to the syringe mounting portion 62b. The syringe 81 of one injection device 80 stores a high-viscosity liquid 38 containing fibrinogen or the like, and the syringe 81 of the other injection device 80 stores a liquid 39 containing thrombin or the like.

The gas supplied from the gas supply source is introduced into the internal space 21 of the gas chamber 20 through the air supply tube 91 and the air filter unit 85 after being decompressed by the regulator 90 . As a result, gas is ejected from each gas ejection portion 24 .
Then, with the discharge ports 31a and 32a of the spray unit 10 directed toward the target biological tissue (for example, an internal organ in the living body), the operator uses the plunger holder 83 to move the plungers of the two injection tools 80. Holding the proximal ends of 82 together, push these two plungers 82 into their respective syringes 81 .
As a result, the liquid 38 is injected from the syringe 81 of one injection tool 80 into the first liquid distribution pipe 31 , and the liquid 39 is injected from the syringe 81 of the other injection tool 80 into the second liquid distribution pipe 32 . Therefore, while the liquid 38 is discharged from the discharge port 31 a of the first liquid circulation pipe 31 , the liquid 39 is discharged from the discharge port 32 a of the second liquid circulation pipe 32 .
In other words, the liquids 38 and 39 are ejected from the ejection ports 31a and 32a while the gas is ejected from the gas ejection portions 24. As shown in FIG.
As a result, the liquid 38 ejected from the ejection port 31a is urged and sprayed mainly by the gas ejected from the gas ejection part 24 in the vicinity of the ejection port 31a, and the liquid 39 ejected from the ejection port 32a is sprayed. The gas ejected from the gas ejection part 24 in the vicinity of the ejection port 32a can be mainly used to energize and spray. Therefore, the mist liquid 38 and the liquid 39 can be mixed and applied to the target living tissue.
The liquid 38 and the liquid 39 sprayed and mixed in the form of a mist function as an adhesive (bioadhesive). That is, fibrinogen is changed to fibrin by the action of thrombin, and the adhesive is coagulated.

Thereafter, the operator stops pushing each plunger 82 into each syringe 81 in order to finish applying the adhesive to the living tissue.
Here, during the period in which the gas is being introduced into the internal space 21, the pressure of the gas in the internal space 21 is in a state of being increased. Therefore, at least after stopping the pushing of each plunger 82 into each syringe 81 and before stopping the introduction of gas into the gas chamber 20, each pump unit 40 is kept in the interior space 21. Compressed by the gas pressure, the internal volume of each pump portion 40 is reduced.
In a state where the pump section 40 is compressed, as an example, as shown in FIG. 6( a ), in the cross section of the pump section 40 , the portions facing each other are in contact or close to each other. Therefore, the internal volume of the pump portion 40 is reduced compared to the internal volume in the natural state.

Furthermore, after that, the introduction of the gas into the gas chamber 20 is stopped. As a result, the pressure of the gas in the internal space 21 is reduced, so that each pump portion 40 is restored to its natural shape, that is, the cylindrical cross-sectional shape as shown in FIG. do. Therefore, the internal volume of each pump portion 40 is increased compared to the compressed state.
Therefore, since the inside of each pump portion 40 temporarily becomes negative pressure, the liquid 38 can be sucked from the discharge port 31a side of the first liquid flow pipe 31 to the pump portion 40 side. That is, the liquid 38 is sucked from the discharge port 31a side to the pump section 40 side in the process of restoring the natural state from the compressed state of the pump section 40 by stopping the introduction of the gas into the gas chamber 20 .
Therefore, it is possible to suppress the liquid 38 from dripping from the ejection port 31a, so that it is possible to suppress the occurrence of the phenomenon in which the solidified substance of the liquid 38 dripping from the ejection port 31a grows. The liquid 38 sucked by the pump section 40 is the liquid 38 closer to the discharge port 31a than the pump section 40. For example, the liquid 38 outside the discharge port 31a (liquid 38 dripping outside) or includes liquid 38 prior to .
In the case of the present embodiment, since the first liquid flow pipe 31 has a plurality of pump parts 40, it is possible to suck the liquid 38 with a stronger suction force than when there is only one pump part 40. FIG. Therefore, it is possible to more reliably prevent the liquid 38 from dripping from the ejection port 31a and the growth of the solidified substance of the liquid 38 dripping from the ejection port 31a.
Therefore, when gas is again introduced into the gas chamber 20 and the liquids 38 and 39 are discharged from the respective liquid circulation tubes to apply the sprayed and mixed liquids 38 and 39 to the biological tissue, the first liquid circulation tube 31 The liquid 38 can be discharged smoothly from the discharge port 31a.

It should be noted that the following effects are also obtained by having the plurality of pump portions 40 in the first liquid flow pipe 31 .
When the gas is introduced into the gas chamber 20 again and the liquids 38 and 39 are discharged from the liquid flow pipes, the pumps 40 are compressed. Therefore, the liquid 38 stored in each pump portion 40 is immediately pushed out toward the discharge port 31a. Therefore, when injection of the liquid 38 by the plunger 82 is restarted, the liquid 38 is quickly discharged from the discharge port 31a with good responsiveness.

Further, in the case of the present embodiment, the specific liquid flow pipe having a plurality of pump units 40 is the first liquid flow pipe 31 that circulates the high-viscosity liquid 38 containing fibrinogen or the like. For this reason, the viscosity of the liquid 38 prevents the liquid 38 from returning to the discharge port 31a side due to its own weight after the liquid 38 is sucked into the pump section 40 by restoring the pump section 40 to its natural state. can be suppressed.

In this embodiment, each pump section 40 has a pump section rib 45b. Therefore, it is possible to sufficiently ensure the elastic restoring force with which each pump portion 40 attempts to restore the cylindrical natural state. That is, the pump section ribs 45b promote restoration of each pump section 40. As shown in FIG.

A ring-shaped boundary rib 37b is formed on the inner peripheral surface of the portion (constricted portion 37) located at the boundary between the first pump portion 41 and the second pump portion 42 in the first liquid flow pipe 31. This portion is reinforced by boundary ribs 37b. As a result, each pump portion 40 can be individually contracted and restored, and the restoration of each pump portion 40 can also be facilitated by the boundary ribs 37b.

[Second embodiment]
Next, a second embodiment will be described with reference to FIG. FIG. 7 is an enlarged cross-sectional view of the vicinity of the pump portion of the specific liquid flow pipe (first liquid flow pipe 31) of the bioadhesive applicator according to this embodiment, and is a cross section along the axis of the first liquid flow pipe 31. It is a diagram.
The bioadhesive applicator according to this embodiment differs from the bioadhesive applicator 100 according to the first embodiment in the following points, and the other points are the same as those in the first embodiment. is configured in the same manner as the bioadhesive applicator 100 according to .

In the case of this embodiment as well, the bioadhesive applicator includes a first pump unit 41 as the plurality of pump units 40, and an upstream side of the specific liquid flow pipe (first liquid flow pipe 31) from the first pump unit 41. and a second pump section 42 located in the .
In this embodiment, the bioadhesive applicator is configured such that the first pumping portion 41 recovers faster than the second pumping portion 42 after ceasing the introduction of gas into the gas chamber 20 .
For this reason, first, the liquid 38 is pumped from the discharge port 31a side by the first pump portion 41, which is arranged closer to the discharge port 31a (front end side) than the first pump portion 41 and the second pump portion 42. After rapidly sucking, the liquid 38 can be further sucked toward the proximal side by the second pump part 42 .
Therefore, it is possible to more reliably prevent the liquid 38 from dripping from the ejection port 31a and the growth of the solidified substance of the liquid 38 dripping from the ejection port 31a.

In the case of the present embodiment, the second pump section 42 is configured more flexibly than the first pump section 41, so that the first pump section 41 is more flexible than the second pump section 41 after the introduction of the gas into the gas chamber 20 is stopped. It is designed to restore faster than 42.
After stopping the introduction of the gas into the gas chamber 20 , the pump section 40 restores its natural cylindrical shape due to the elastic force (elastic restoring force) of the pump section 40 . The larger the elastic restoring force, the faster the pump part 40 restores to the natural state.
In the present embodiment, since the second pump portion 42 is configured to be more flexible than the first pump portion 41, the elastic restoring force of the first pump portion 41 is greater than the elastic restoring force of the second pump portion 42. .
Since the compression ratio of the second pump unit 42 due to the gas pressure in the internal space 21 is higher than the compression ratio of the first pump unit 41 due to the gas pressure, the volume of the liquid 38 that can be sucked by the second pump unit 42 is can be more fully ensured.
As a technique for configuring the second pump section 42 more flexibly than the first pump section 41, there is a technique for forming the second pump section 42 from a material that is more flexible than the first pump section 41. A method of differentiating molding conditions for the second pump portion 42 and the first pump portion 41 so that the second pump portion 42 and the first pump portion 41 are softer than the pump portion 41, and For example, a method of making the thickness larger than the thickness.

In the case of this embodiment, as shown in FIG. 7, the second pump portion 42 is more flexible than the first pump portion 41 because the thickness of the first pump portion 41 is greater than the thickness of the second pump portion 42 . and the first pump section 41 recovers faster than the second pump section 42 after stopping the introduction of gas into the gas chamber 20 .
The thickness of the first pump portion 41 is greater than the thickness of the second pump portion 42, so that the compression ratio of the second pump portion 42 due to the gas pressure in the internal space 21 is the same as that of the first pump portion 42 due to the gas pressure. It becomes larger than the compression ratio of the portion 41 .

As shown in FIG. 7, the thickness of the main portion 45a of the cylindrical portion 45 of the first pump portion 41 is T1, and the thickness of the main portion 45a of the cylindrical portion 45 of the second pump portion 42 is T2.
In this embodiment, the thickness T1 is set to be larger than the thickness T2. Accordingly, the average thickness of the entire first pump portion 41 including the cylindrical portion 45 and the tapered portion 46 is reduced to the average thickness of the entire second pump portion 42 including the cylindrical portion 45 and the tapered portion 46. greater than the thickness.

In the case of this embodiment, the protrusion height and number of the pump section ribs 45b in the first pump section 41 and the protrusion height and number of the pump section ribs 45b in the second pump section 42 are equal to each other.
However, the present invention is not limited to this example. The overall average wall thickness of the pump section 41 is made larger than the overall average wall thickness of the second pump section 42 , and after stopping the introduction of the gas into the gas chamber 20 , the first pump section 41 is thicker than the second pump section 41 . You may make it restore|restore faster than the part 42. FIG. Further, by making the arrangement density of the pump section ribs 45b in the first pump section 41 higher than the arrangement density of the pump section ribs 45b in the second pump section 42, the average thickness of the entire first pump section 41 can be reduced. , the average wall thickness of the entire second pump section 42 is made larger than that of the second pump section 42 so that the first pump section 41 recovers faster than the second pump section 42 after the introduction of the gas into the gas chamber 20 is stopped. good.

[Third embodiment]
Next, a third embodiment will be described with reference to FIG. FIG. 8 is an enlarged cross-sectional view of the vicinity of the pump portion of the specific liquid flow pipe (first liquid flow pipe 31) of the bioadhesive applicator according to this embodiment, and is a cross section along the axis of the first liquid flow pipe 31. It is a diagram.
The bioadhesive applicator according to this embodiment differs from the bioadhesive applicator 100 according to the first embodiment or the bioadhesive applicator according to the second embodiment in the following points. , and other points, are configured in the same manner as the bioadhesive applicator 100 according to the first embodiment or the bioadhesive applicator according to the second embodiment.

In the case of this embodiment, the internal volume of the second pump section 42 is larger than the internal volume of the first pump section 41 . The internal volume here means the internal volume when each pump portion 40 is in the natural state.
Since the internal volume of the second pump section 42 is larger than the internal volume of the first pump section 41, the liquid that can be sucked by the second pump section 42 is larger than the volume of the liquid 38 that can be sucked by the first pump section 41. 38 has a large volume. Therefore, the liquid 38 sucked by the first pump portion 41 can be more reliably sucked by the second pump portion 42 .
As shown in FIG. 8, the axial length dimension of the cylindrical portion 45 of the first pump portion 41 is L11, and the axial length dimension of the cylindrical portion 45 of the second pump portion 42 is L21.
In the case of this embodiment, the length dimension L21 is larger than the length dimension L11. And the internal volume of the entire second pump portion 42 including the taper portion 46 is increased.
Also in this embodiment, the inner diameter of the main portion 45a of the cylindrical portion 45 in the first pump portion 41 and the inner diameter of the main portion 45a of the cylindrical portion 45 in the second pump portion 42 are equal to each other.
However, the present invention is not limited to this example. , the internal volume of the second pump section 42 may be larger than the internal volume of the first pump section 41 .

[Fourth embodiment]
Next, a fourth embodiment will be described with reference to FIGS. 9(a) and 9(b). 9(a) and 9(b) are enlarged views showing the vicinity of the pump portion of the specific liquid flow pipe (first liquid flow pipe 31) of the bioadhesive applicator according to the fourth embodiment. 9(a) is a cross-sectional view along the axis of the first liquid flow pipe 31, and FIG. 9(b) is a plan view.
The bioadhesive applicator according to the present embodiment is the bioadhesive applicator 100 according to the first embodiment, the bioadhesive applicator according to the second embodiment, or the third embodiment, in terms of the points described below. In other respects, the bioadhesive applicator 100 according to the first embodiment, the bioadhesive applicator according to the second embodiment, or the third embodiment It is configured in the same manner as the bioadhesive applicator.

As shown in FIGS. 9(a) and 9(b), the bioadhesive applicator according to the present embodiment has a plurality of pump parts 40 which are more specific liquid flow pipes (first liquid than second pump part 42). It further comprises a third pump section 43 arranged upstream in the flow pipe 31).
Therefore, the liquid 38 can be sucked from the discharge port 31a side to the pump section 40 side with a stronger suction force.

In the case of this embodiment, the constricted portions 37 are arranged between the first pump portion 41 and the second pump portion 42 and between the second pump portion 42 and the third pump portion 43, respectively.
In the case of this embodiment, the second pump portion 42 does not include the tapered portion 46 and is composed of the cylindrical portion 45 .
Further, the third pump portion 43 includes, for example, a cylindrical portion 45 and a taper portion 46 connected to the base end side of the cylindrical portion 45, similarly to the second pump portion 42 described in the first embodiment. have.
In the case of the present embodiment, for example, the protrusion height and arrangement density of the pump section ribs 45b of each pump section 40 are equal to each other.

<Modification of Fourth Embodiment>
Next, the modification of 4th Embodiment is demonstrated using Fig.10 (a) and FIG.10(b). 10(a) and 10(b) are enlarged views showing the vicinity of the pump portion of the specific liquid flow pipe (first liquid flow pipe 31) of the bioadhesive applicator according to the modified example of the fourth embodiment. Among them, FIG. 10(a) is a cross-sectional view along the axis of the first liquid flow pipe 31, and FIG. 10(b) is a plan view.
The bioadhesive applicator according to this modification differs from the bioadhesive applicator according to the fourth embodiment in the points described below, and in other respects, it is different from the bioadhesive applicator according to the fourth embodiment. It is configured in the same manner as the bioadhesive applicator.

As shown in FIG. 10A, in the case of this modification, the inner diameter and the outer diameter of the non-pump portion 35 are constant over the entire non-pump portion 35 .

As shown in FIGS. 10A and 10B, in the case of this modification, the number of pump portion ribs 45b in each pump portion 40 is, for example, two. Accordingly, for the cylindrical portion 45 of each pump portion 40, the outer diameter of the main portion 45a is equal to or larger than the dimension of the cylindrical portion 45 in the axial direction.
Therefore, it is easier to sufficiently ensure the compression ratio (the ratio of reduction in the internal volume) of (the cylindrical portion 45 of) each pump portion 40 due to the external pressure (the gas pressure in the internal space 21).

The present invention is not limited to the above-described embodiments and modifications thereof, and includes various modifications and improvements as long as the object of the present invention is achieved.

For example, in the above description, the number of liquid circulation tubes included in the bioadhesive applicator 100 is two, and one of the liquid circulation tubes (for example, the first liquid circulation tube 31) has a plurality of pump parts 40. An example has been described that is a liquid flow conduit. However, the present invention is not limited to this example, and the bioadhesive applicator 100 may have three or more liquid circulation tubes, or the number of specific liquid circulation tubes may be two or more. Further, all the liquid distribution tubes included in the bioadhesive applicator 100 may be specific liquid distribution tubes.
However, it is preferable that the liquid flow pipe through which the high-viscosity liquid containing fibrinogen or the like flows is the specific liquid flow pipe.

Also, in the case where the specific liquid flow pipe has three or more pump parts 40, the restoration speed of the pump parts 40 positioned further to the distal end side is faster, as in the second embodiment. is also preferred.
For example, in the fourth embodiment or its modification, the average thickness of the entire first pump section 41 is made larger than the average thickness of the entire second pump section 42, and the thickness of the entire second pump section 42 is The average thickness is made larger than the average thickness of the entire third pump portion 43 . As a result, after stopping the introduction of the gas into the gas chamber 20, the first pump section 41 recovers faster than the second pump section 42, and the second pump section 42 recovers faster than the third pump section 43. can. By doing so, after the liquid 38 is rapidly sucked from the discharge port 31a side by the first pump part 41, the liquid 38 is further sucked to the base end side by the second pump part 42, and then the second The liquid 38 can be sucked further to the base end side by the 3-pump section 43 .
More specifically, for example, the protrusion height of the pump section ribs 45b in the first pump section 41 is made larger than the protrusion height of the pump section ribs 45b in the second pump section 42, and the pump section ribs in the second pump section 42 are The protrusion height of 45b can be made larger than the protrusion height of pump part rib 45b in the third pump part 43 .

Further, in contrast to the second embodiment, a configuration may be adopted in which the restoration speed of the pump portion 40 positioned closer to the base end is faster.
For example, by making the overall average wall thickness of the second pump section 42 larger than the overall average wall thickness of the first pump section 41, the second pump section 42 can be It is possible for the section 42 to recover faster than the first pump section 41 .
In this case, since the elastic restoring force of the second pump portion 42 located on the proximal side is larger, first, after the liquid 38 on the distal side of the second pump portion 42 is entirely sucked, the liquid 38 located on the distal side is The liquid 38 can be further sucked from the side of the discharge port 31a by the first pump portion 41.
In this case, the compression ratio of the first pump portion 41 due to the gas pressure in the internal space 21 is higher than the compression ratio of the second pump portion 42 due to the gas pressure.
More specifically, for example, the protrusion height of the pump section ribs 45 b in the second pump section 42 can be made larger than the protrusion height of the pump section ribs 45 b in the first pump section 41 .

Furthermore, even when the specific liquid flow pipe has three or more pump sections 40, the restoration speed of the pump sections 40 located closer to the proximal end is faster, contrary to the second embodiment. It is also preferable to configure
For example, in the fourth embodiment or its modification, the average thickness of the entire first pump section 41 is made smaller than the average thickness of the entire second pump section 42, and the overall average thickness of the second pump section 42 is The average thickness is made smaller than the average thickness of the entire third pump portion 43 . As a result, after stopping the introduction of the gas into the gas chamber 20, the third pump section 43 recovers faster than the second pump section 42, and the second pump section 42 recovers faster than the first pump section 41. can. By doing so, after the liquid 38 is rapidly sucked from the discharge port 31 a side by the third pump section 43 , the liquid 38 is further sucked by the second pump section 42 , and then the liquid 38 is sucked by the first pump section 41 . , and further liquid 38 can be aspirated.
More specifically, for example, the protrusion height of the pump section ribs 45b in the second pump section 42 is made larger than the protrusion height of the pump section ribs 45b in the first pump section 41, and the pump section ribs in the third pump section 43 are made larger. The protrusion height of 45b can be made larger than the protrusion height of pump part rib 45b in the second pump part 42 .

Further, in the above, the first liquid flow pipe 31 is configured by combining a plurality of members (the first liquid flow pipe main body 33, the distal end side member 70, and the base end side member 60), and the second liquid flow pipe 32 is also configured by combining a plurality of members (the second liquid flow pipe main body 34, the distal side member 70, and the proximal side member 60), but each liquid flow pipe is integrally formed as a whole. It may be composed of a single member.

Moreover, the above-described embodiments and modifications can be appropriately combined without departing from the gist of the present invention.

This embodiment includes the following technical ideas.
(1) a gas chamber having a gas introduction portion into which gas is introduced and a gas ejection portion from which the gas is ejected;
a plurality of liquid flow pipes passing through the interior space of the gas chamber and having discharge ports arranged near the gas discharge portion;
with
A bioadhesive applicator that sprays and mixes liquids ejected from the ejection ports of the plurality of liquid flow tubes and applying them to living tissue by urging them with the gas ejected from the gas ejection part. and
A specific liquid distribution pipe, which is at least one liquid distribution pipe among the plurality of liquid distribution pipes, has a plurality of pump portions respectively configured by different parts in the axial direction of the specific liquid distribution pipe,
A portion of the specific liquid flow pipe located between the plurality of pump portions is a constricted portion having a diameter smaller than that of the pump portion,
Each of the plurality of pump parts is compressed by the gas pressure to reduce the internal volume while the gas is being introduced into the gas chamber, and is elastically restored when the introduction of the gas into the gas chamber is stopped. bioadhesive applicator.
(2) including, as the plurality of pump units, a first pump unit and a second pump unit arranged upstream of the first pump unit in the specific liquid flow pipe;
The bioadhesive applicator according to (1), wherein the first pump section is configured to recover faster than the second pump section after ceasing the introduction of the gas into the gas chamber.
(3) The bioadhesive applicator according to (2), wherein the second pump section is more flexible than the first pump section.
(4) The bioadhesive applicator according to (2) or (3), wherein the thickness of the first pump section is greater than the thickness of the second pump section.
(5) The bioadhesive applicator according to any one of (2) to (4), wherein the internal volume of the second pump section is larger than the internal volume of the first pump section.
(6) In the specific liquid flow pipe, a ring-shaped boundary rib is formed on the inner peripheral surface of the portion located on the boundary between the first pump section and the second pump section (1) to ( The bioadhesive applicator according to any one of 5).
(7) According to (6), a pump portion rib having a height lower than that of the boundary rib is formed on at least one of the outer peripheral surface and the inner peripheral surface of the first pump portion and the second pump portion. Bioadhesive applicator.
(8) any one of (2) to (7), further including, as the plurality of pump sections, a third pump section arranged upstream in the specific liquid flow pipe relative to the second pump section; A bioadhesive applicator as described.

10 spray unit 20 gas chamber 21 internal space 22 gas introduction part 23 gas flow passage 24 gas ejection part 25 partition wall part 31 first liquid flow pipe (liquid flow pipe, specific liquid flow pipe)
31a discharge port 32 second liquid distribution pipe (liquid distribution pipe)
32a discharge port 33 first liquid flow pipe body 33a base end portion 33b tip end portion 34 second liquid flow pipe body 34a base end portion 34b tip end portion 35 non-pump portion 35a straight pipe portion 35b tip portion 36 non-pump portion 36a straight pipe portion 36b Base end portion 37 Constricted portion 37a Main portion 37b Boundary ribs 38, 39 Liquid 40 Pump portion 41 First pump portion 42 Second pump portion 43 Third pump portion 45 Cylindrical portion 45a Main portion 45b Pump portion rib 46 Tapered portion 50 Chamber Body 51 Base end portion 51a Base end side opening 52 Tip end portion 52a Insertion hole 52b Fixing rib 60 Base end side member 61 Main body portions 62a, 62b Syringe mounting portions 63a, 63b Liquid distribution tube mounting portions 64a, 64b Through hole 65 Partition wall configuration Part 70 Tip side member 71 First discharge pipes 71a, 72a Holding parts 71b, 72b Protruding part 72 Second discharge pipe 73 Connecting part 80 Injection tool 81 Syringe 82 Plunger 83 Plunger holder 85 Air filter unit 85a Connection part 90 Regulator 91 Air supply Tube 92a First connector 92b Second connector 100 Bioadhesive applicator

Claims (8)

a gas chamber having a gas introduction part into which gas is introduced and a gas ejection part from which the gas is ejected;
a plurality of liquid flow pipes passing through the interior space of the gas chamber and having discharge ports arranged near the gas discharge portion;
with
A bioadhesive applicator that sprays and mixes liquids ejected from the ejection ports of the plurality of liquid flow tubes and applying them to living tissue by urging them with the gas ejected from the gas ejection part. and
A specific liquid distribution pipe, which is at least one liquid distribution pipe among the plurality of liquid distribution pipes, has a plurality of pump portions respectively configured by different parts in the axial direction of the specific liquid distribution pipe,
A portion of the specific liquid flow pipe located between the plurality of pump portions is a constricted portion having a diameter smaller than that of the pump portion,
Each of the plurality of pump parts is compressed by the gas pressure to reduce the internal volume while the gas is being introduced into the gas chamber, and is elastically restored when the introduction of the gas into the gas chamber is stopped. bioadhesive applicator. The plurality of pump units include a first pump unit and a second pump unit arranged upstream of the first pump unit in the specific liquid flow pipe,
2. The bioadhesive applicator of claim 1, wherein the first pump section is configured to recover faster than the second pump section after ceasing introduction of the gas to the gas chamber. 3. The bioadhesive applicator according to claim 2, wherein said second pump section is more flexible than said first pump section. 4. The bioadhesive applicator according to claim 2, wherein the thickness of the first pump portion is greater than the thickness of the second pump portion. The bioadhesive applicator according to any one of claims 2 to 4, wherein the internal volume of the second pump section is larger than the internal volume of the first pump section. 6. A ring-shaped boundary rib is formed on an inner peripheral surface of a portion of the specific liquid flow pipe located at a boundary between the first pump section and the second pump section. The bioadhesive applicator according to claim 1. 7. The bioadhesive according to claim 6, wherein a pump portion rib having a lower height than the boundary rib is formed on at least one of the outer peripheral surface and the inner peripheral surface of the first pump portion and the second pump portion. applicator. 8. The bioadhesive according to any one of claims 2 to 7, further comprising, as the plurality of pump parts, a third pump part arranged upstream of the second pump part in the specific liquid flow pipe. applicator.

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