JP7330489B2 - Skin topical agent - Google Patents

Description

TECHNICAL FIELD The present invention relates to a highly safe functional material having an excellent anti-inflammatory action and an external skin preparation (cosmetics, etc.) containing the same.

Aging, dryness, and rough skin are induced by internal factors such as inactivation of cell proliferation and differentiation, decreased hormone secretion, and quantitative decrease in extracellular matrix components, as well as sunlight (ultraviolet rays). It is a phenomenon that is caused by complex intertwining with external factors such as damage to cells/tissues due to active oxygen, or inflammation.

Active oxygen, which is an external factor of skin aging, not only directly damages skin cells, but also denatures or cross-links extracellular matrix components, etc., resulting in wrinkle formation and reduced skin elasticity. It causes various damages to the skin, such as inflammation, spots, and freckles by inducing abnormal deposition of

In order to prevent this skin inflammation and maintain the skin in a healthy and youthful state, the use of various active ingredients has been proposed in the past. A topical skin preparation containing For example, anti-inflammatory agents such as glycyrrhizic acid and allantoin are known, and are widely used as components of external preparations for skin. In addition, as described in Patent Documents 1 to 4, topical preparations for skin containing plant-derived components have also been proposed.

However, these conventional ingredients have problems in terms of safety to the skin and the efficacy when actually applied to the skin. Accordingly, there is a demand for a naturally derived anti-inflammatory component for external skin preparations that is improved in these respects.

JP 2014-169253 JP 2006-143670 Japanese Patent Application Laid-Open No. 01-090131 JP-A-50-135236

In view of the problems of the prior art, the present inventors conducted intensive research to discover new anti-inflammatory ingredients derived from natural products and ingredients that prevent and improve pigmentation from the viewpoint of skin safety. As a result, the combined use of extracts from a plurality of plants makes it possible to provide an external preparation for skin that exhibits an excellent anti-inflammatory effect, an effect of preventing and improving pigmentation, and excellent skin safety. The inventors have found that and completed the present invention.

The present invention provides (1) an extract of perilla of the Labiatae (Lamiaceae) genus Perilla, (2) an extract of a plant belonging to the genus Hemerocallis of the family Liliaceae, (3) the genus Cupressaceae of Juniperus (Juniperus) and (4) an extract of mulberry belonging to the genus Morus of the family Moraceae as active ingredients.

The present invention provides (1) an extract of perilla of the Labiatae family (Lamiaceae), the genus Perilla, (2) an extract of a plant belonging to the genus Hemerocallis of the family Liliaceae, and (3) the Cupressaceae family An anti-inflammatory agent for external use for skin containing, as active ingredients, a juniper berry extract of the genus Juniperus and (4) an extract of mulberry belonging to the genus Morus of the family Moraceae, wherein the active ingredients have anti-inflammatory properties It is possible to provide an external preparation for skin such as a cosmetic that exerts an effect and an effect of preventing and improving pigmentation.

FIG. 1 is a diagram showing the measurement results of erythema change.

"Perilla" used in the present invention is a perilla of the family Lamiaceae, the genus Perilla, and is generally represented by the scientific name Perilla frutescensvar. Crispa or Perilla frutescensvar. Britton, Examples thereof include blue perilla, chirimenjiso, red perilla, common red perilla, katamenjiso, chirimen perilla, and variants or subspecies thereof, or hybrids thereof, but the present invention is not limited thereto. In addition, although any of perilla plants, leaves, flowers, stems, seeds, fruits, roots, etc. may be used, it is preferable to use whole plants, or leaves, flowers, stems and/or fruits, especially leaves. and/or the use of inflorescences is preferred. In addition, there are no particular restrictions on the timing, size, and the like of the part of perilla used, and any size and timing may be used.

Plants belonging to the genus Formosan of the family Liliaceae used in the present invention include, for example, Hemerocallis fulva var. fulva, Hemerocallis fulva var. kwanso, Hemerocallis fulva var. littorea, and Hemerocallis fulva var. longituba. , daylily (Hemerocallis fulva) such as daylily (Hemerocallis fulva var. sempervirens), curcuma licorice (Hemerocallis citrina Baroni), licorice (Hemerocallis dumortieri var. dumortieri), manchurian lily (Hemerocallis lilioasphodelus L.), small yellow flower rape (Hemerocallis mirror ), Hemerocallis lilioasphodelus var. yezoensis, Hemerocallis dumortieri var. esculenta, Hemerocallis citrina var. vespertina, or Hemerocallis plicata.

The "juniper berry" used in the present invention is a juniper berry (scientific name: Juniperus communis) belonging to the genus Juniperus of the family Cupressaceae. The parts that can be used in the present invention include whole plants, leaves, flowers, fruits, stems, seeds, roots, etc., but the use of whole plants or fruits is preferred.

The "mulberry" used in the present invention includes mulberry (scientific name: Morus alba) belonging to the genus Morus of the family Moraceae. Sites that can be used in the present invention include whole plants, leaves, stems, seeds, roots and the like, and use of whole plants or roots is preferred.

A method for preparing an extract using the above plants will be described below. Extracts are prepared by washing, drying, finely chopping or pulverizing the parts of each plant to be extracted, if necessary, and subjecting them to conventional methods such as immersion, countercurrent extraction, and supercritical extraction. It can be carried out by contacting the extraction solvent by

Examples of extraction solvents include water; lower alcohols such as methanol, ethanol and propanol; polyhydric alcohols such as ethylene glycol, 1,3-propylene glycol, 1,3-butylene glycol and glycerin; ethyl acetate, butyl acetate and propion. esters such as methyl acid; ketones such as acetone and methyl ethyl ketone; ethers such as ethyl ether and isopropyl ether; hydrocarbon solvents such as n-hexane, toluene, and chloroform; The above are mixed and used.

In addition, when preparing the extract of the present invention, it is generally preferable to keep the pH in the range of 3 to 8. In this sense, if necessary, the extraction solvent is added with an alkaline solution such as sodium hydroxide, sodium carbonate, potassium hydroxide, etc. An adjusting agent or an acid adjusting agent such as citric acid, hydrochloric acid, phosphoric acid, and sulfuric acid may be added to adjust the desired pH. Extraction conditions such as extraction temperature and extraction time vary depending on the type and pH of the solvent used, or the fineness and particle size of the material to be extracted. The extraction temperature generally ranges from 1 to 90° C. and the extraction time ranges, for example, from 0.5 to 96 hours at room temperature.

The extract prepared as described above may generally be adjusted to a pH of 3 to 8 and then used as it is as a cosmetic compounding agent. You can Also, the extract may be dried by a conventional method such as a spray drying method.

The mixture solution of the extracts according to the present invention can be blended into external skin preparations (cosmetics, quasi-drugs, external pharmaceuticals). Examples of external agents for skin include emulsion, cream, lotion, essence, pack, lipstick, foundation, liquid foundation, makeup press powder, blush, white powder, facial cleanser, body shampoo, packs and masks (cleaning packs, oil packs, cleansing masks, impregnated sheet masks, etc.), shampoos for scalp and hair, conditioners for hair, shampoos or tonics for hair growth and hair growth, cleansing cosmetics such as soaps, and bath additives. The present invention is not limited to these.

External skin preparations (cosmetics and quasi-drugs) include, in addition to the extract according to the present invention, components normally used in external skin compositions, such as oily components, surfactants (synthetic, natural ), moisturizing agents, thickeners, antiseptic/bactericidal agents, powder components, ultraviolet absorbers, antioxidants, chelating agents, pigments, fragrances, and the like can be appropriately blended as necessary. In addition, as long as the effectiveness and characteristics of the extract, hydrolyzate, or fermented product according to the present invention are not impaired, other physiologically active ingredients may be used in combination.

Examples of oily components include lotus oil, olive oil, jojoba oil, castor oil, soybean oil, rice oil, rice bran oil, rice germ oil, coconut oil, chamomile oil, palm oil, cacao oil, meadowfoam oil, Bergamot oil, rosehip oil, Arabic coffee tree seed oil, lavender oil, shea butter, tea tree oil, avocado oil, macadamia nut oil, vanilla oil, plant-derived oils such as squalane; mink oil, turtle oil, etc. Animal-derived oils and fats; Waxes such as beeswax, carnauba wax, rice wax, and lanolin; Hydrocarbons such as liquid paraffin, petrolatum, paraffin wax, and squalane; Myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, eicosene Fatty acids such as acids; Higher alcohols such as lauryl alcohol, cetanol, and stearyl alcohol; ) and synthetic triglycerides.

Examples of surfactants include polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyethylene glycol fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, poly Nonionic surfactants such as oxyethylene hydrogenated castor oil and polyoxyethylene sorbitol fatty acid ester; Anionic surfactants such as ethylene alkylphenyl ether sulfates, polyoxyethylene alkyl ether phosphates, α-sulfonated fatty acid alkyl ester salts, polyoxyethylene alkylphenyl ether phosphates; quaternary ammonium salts, primary to secondary Tertiary fatty amine salts, trialkylbenzylammonium salts, alkylpyridinium salts, 2-alkyl-1-alkyl-1-hydroxyethylimidazolinium salts, N,N-dialkylmorphonium salts, polyethylenepolyamine fatty acid amide salts, etc. Cationic surfactant; N,N-dimethyl-N-alkyl-N-carboxymethylammoniobetaine, N,N,N-trialkyl-N-alkyleneammoniocarboxybetaine, N-acylamidopropyl-N',N Amphoteric surfactants such as '-dimethyl-N'-β-hydroxypropylammoniosulfobetaine can be used.

Examples of emulsifiers or emulsifying aids include stevia derivatives such as enzyme-treated stevia, saponin or its derivatives, casein or its salts (sodium, etc.), sugar-protein complexes, sucrose or its esters, lactose, soybean-derived Water-soluble polysaccharide, complex of soybean-derived protein and polysaccharide, lanolin or its derivative, cholesterol, stevia derivative (stevia enzyme fermented product, etc.), silicate (aluminum, magnesium, etc.), carbonate (calcium, sodium, etc.), saponin and derivatives thereof, lecithin and its derivatives (hydrogenated lecithin, etc.), lactic acid bacteria fermented rice, lactic acid bacteria fermented germinated rice, lactic acid bacteria fermented grains (wheat, beans, cereals, etc.), etc. can also be blended.

Examples of moisturizing agents include glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidone carboxylate, and 2-methacryloyloxyethylphosphorylcholine/butyl methacrylate copolymer liquid. etc., and further sugars such as trehalose, mucopolysaccharides (e.g., hyaluronic acid and its derivatives, chondroitin and its derivatives, heparin and its derivatives, etc.), tuberose polysaccharides, elastin and its derivatives, collagen and its derivatives, NMF-related Substances, hydrolyzed conchiolin, hydrolyzed silk, sphingomonas culture, glycosphingolipid, ceramide, lactic acid, urea, higher fatty acid octyldodecyl, seaweed extract, sylvatica root extract, various amino acids and their derivatives mentioned.

Examples of thickeners include alginic acid, agar, carrageenan, fucoidan, and other brown algae, green algae, or red algae-derived components; Birlan root (white) extract; pectin, locust bean gum, aloe polysaccharide, and Alcaligenes-producing polysaccharide. Polysaccharides such as polysaccharides; gums such as xanthan gum, tragacanth gum, roasted bean gum, guar gum; cellulose derivatives such as carboxymethylcellulose and hydroxyethylcellulose; polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, mastic resin, acrylic acid/methacrylic acid copolymer Synthetic polymers such as conjugates; hyaluronic acid and its derivatives; polyglutamic acid and its derivatives;

Examples of antiseptic/bactericidal agents include urea; paraoxybenzoic acid esters such as methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, and butyl parahydroxybenzoate; phenoxyethanol, dichlorophen, hexachlorophene, and chlorhexidine hydrochloride. , benzalkonium chloride, salicylic acid, ethanol, undecylenic acid, phenols, jamal (imidazodenyl urea), polyphosphoric acid, propanediol, 1,2-pentanediol, various essential oils, dry distillation of bark, fermented radish, sugar cane plant-derived ethanol or 1,3-butylene glycol.

Examples of powder components include sericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, nylon powder, polyethylene powder, and silk. There are powders, cellulose-based powders, powders of grains (rice, wheat, corn, millet, etc.), and powders of beans (soybeans, adzuki beans, etc.).

Examples of UV absorbers include ethyl para-aminobenzoate, ethylhexyl para-dimethylaminobenzoate, amyl salicylate and derivatives thereof, 2-ethylhexyl para-methoxycinnamate, octyl cinnamate, oxybenzone, 2,4-dihydroxybenzophenone, 2- Hydroxy-4-methoxybenzophenone-5-sulfonate, 4-tert-butyl-4-methoxybenzoylmethane, 2-(2-hydroxy-5-methylphenyl)benzotriazole, urocanic acid, ethyl urocanate, aloe extract etc.

Antifoaming agents include, for example, ethanol, isopropanol, disiloxane, dimethylpolycyclosan, silica dimethicone silicate, trisiloxane, silica silylate, dimethicone, trimethylsiloxysilicate, and DPG isobornyl ether.

Antioxidants include, for example, butylhydroxyanisole, butylhydroxytoluene, propyl gallate, purslane extract, sycamore root extract, peony extract, vitamin E and derivatives thereof (e.g., vitamin E nicotinate, vitamin E linoleate, etc.).

Examples of chelating agents include trisodium ethylenediaminehydroxyethyltriacetate, edetic acid or salts thereof, gluconic acid, phytic acid, sodium polyphosphate, sodium metaphosphate, tetrasodium hydroxyethanediphosphonate, and the like.

Examples of pH adjusters include citric acid or salts thereof, lactic acid or salts thereof, glycolic acid, succinic acid, hydrochloric acid, monoethanolamine, diethanolamine, triethanolamine, sodium hydroxide and potassium hydroxide.

As whitening agents, t-cycloamino acid derivatives, kojic acid and its derivatives, ascorbic acid and its derivatives, hydroquinone and its derivatives, ellagic acid and its derivatives, nicotinic acid and its derivatives, resorcinol derivatives, tranexamic acid and its derivatives , 4-methoxysalicylic acid potassium salt, magnolignan (5,5'-dipropyl-biphenyl-2,2'-diol), hydroxybenzoic acid and its derivatives, vitamin E and its derivatives, α-hydroxy acid, AMP (adenosine mono phosphate, adenosine monophosphate), and these may be blended singly or in combination.

Examples of the above kojic acid derivatives include kojic acid esters such as kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate and kojic acid dibutyrate; kojic acid sugars such as kojic acid ethers and kojic acid glucoside; Ascorbic acid derivatives such as L-ascorbic acid-2-phosphate sodium, L-ascorbic acid-2-phosphate magnesium, L-ascorbic acid-2-sulfate sodium, L-ascorbic acid -Ascorbic acid ester salts such as 2-sulfate magnesium, L-ascorbic acid-2-glucoside, L-ascorbic acid-5-glucoside, ascorbyl tocopheryl maleate, ascorbyl tocopheryl potassium phosphate, myristyl 3-glyceryl ascorbate , ascorbic acid sugar derivatives such as caprylyl 2-glyceryl ascorbic acid, 6-position acylated products of these ascorbic acid sugar derivatives (acyl group is hexanoyl group, octanoyl group, decanoyl group, etc.), L-ascorbic acid tetraisopalmitate, L-ascorbic acid tetra-fatty acid esters such as L-ascorbic acid tetralaurate, 3-O-ethylascorbic acid, L-ascorbic acid-2-phosphate-6-O-palmitate sodium, glyceryl ascorbic acid or its Acylated derivatives, ascorbic acid glycerol derivatives such as bisglyceryl ascorbic acid, aminopropyl L-ascorbate phosphate, hyaluronic acid derivatives of L-ascorbic acid, 3-OD lactose-L-ascorbic acid, isostearyl ascorbyl phosphate Salts, hydroquinone derivatives such as arbutin (hydroquinone-β-D-glucopyranoside), α-arbutin (hydroquinone-α-D-glucopyranoside), etc., and tranexamic acid derivatives such as tranexamic acid esters (eg, lauryl tranexamic acid) ester, tranexamic acid hexadecyl ester, tranexamic acid cetyl ester or a salt thereof), amides of tranexamic acid (e.g., tranexamic acid methylamide), etc., and resorcinol derivatives include, for example, 4-n-butylresorcinol, 4- isoamylresorcinol and the like, and 2,5-dihydroxybenzoic acid derivatives such as 2,5-diacetoxybenzoic acid, 2-acetoxy-5-hydroxybenzoic acid, 2-hydroxy-5-propionyloxybenzoic acid, and nicotinic acid. Examples of derivatives include nicotinamide and benzyl nicotinate. Examples of α-hydroxy acids include lactic acid, malic acid, succinic acid, citric acid and α-hydroxyoctanoic acid.

Examples of physiologically active components include placenta extract, saxifrage extract, rice bran extract or hydrolyzate thereof, white mustard extract or hydrolyzate thereof, fermented white mustard, peony extract or hydrolyzate thereof. lactic acid bacteria fermented rice, purple extract, lotus seed extract or its hydrolyzate, lotus seed fermented product, pearl barley hydrolyzate, fermented pearl barley seed product, royal jelly fermented product, sake lees extract or ceramide contained therein, sake lees fermentation , Pandanus amaryllifolius Roxb. extract, Arcangelicia flava Merrilli extract, chamomile extract and the like. In addition, coral grass extract, rice leaf extract or its hydrolyzate, eggplant (lotus, long eggplant, Kamo eggplant, rice eggplant, etc.) extract or its hydrolyzate, apricot fruit extract, eucheuma cornflower, etc. seaweed extract, marine flowering plant extract such as eelgrass, fermented soymilk, jellyfish water, rice extract or its hydrolyzate, fermented rice extract, germinated rice extract or its hydrolyzate, fermented germinated rice , black soybean extract or its hydrolyzate, brown sugar extract or its fermented product, damask rose flower extract, ylang ylang flower extract, bamboo shoot skin extract, linoleic acid and its derivatives or processed products (e.g. liposomal linoleic acid, etc.), animal- or fish-derived collagen and its derivatives, elastin and its derivatives, glycyrrhizic acid and its derivatives (dipotassium salt, etc.), t-cycloamino acid derivatives, vitamin A and its derivatives, allantoin, diisopropylamine dichloro Acetate, γ-amino-β-hydroxybutyric acid, gentian extract, licorice extract, carrot extract, panax ginseng extract or its fermented product, camellia extract, red ginseng extract, honey kelp extract, loofah extract, sea lettuce extract peach extract, plum extract, peach kernel extract, kiwi extract, sunflower extract, Zizyphus joazeiro extract, Pau d'Arco bark extract, hibiscus flower extract or ferment, red wormwood extract, cherimoya extract extract, Mango extract, Mangosteen extract, Funori extract, Oolong tea extract, Beni Fugui extract, Branth extract, Sweet potato extract, Japanese pepper peel or seed coat extract or hydrolyzate, Safflower flower extract, Casablanca extract sweet potato extract or its fermented product, guava leaf extract, olive leaf extract, horse chestnut extract, ginger extract, vanilla extract, houttuynia cordata extract, banpeiyu extract, aloe extract, aloe vera extract , fig flower extract, apple extract, white asparagus extract, etc.

EXAMPLES Next, the present invention will be described in more detail by production examples, formulation examples, examples and test examples, but the present invention is not limited thereto. In the following, all parts mean parts by weight, and all percentages mean weight %.

Production example 1. Preparation of perilla leaf extract 200 g of purified water was added to 20 g of dried and coarsely pulverized perilla leaves and immersed at 4°C, and then 200 g of 1,3-butylene glycol was added. This was extracted at 4° C. and then filtered to obtain 352 g of a brown transparent filtrate (solid concentration: 1.01%). After that, 234 g of purified water was added to obtain 590 g of a perilla leaf extract solution (solid concentration: 0.61%).

Production Example 2-1. Preparation of Licorice Licorice Extract 200 g of purified water was added to 10 g of finely chopped dried and pulverized flowers of Licorice licorice, and the mixture was immersed at 4° C., followed by addition of 200 g of 1,3-butylene glycol. This was extracted at 4° C. and then filtered to obtain 374 g of a brown transparent filtrate (solid concentration: 1.24%). After that, 249 g of purified water was added to obtain 623 g of a liquorice extract solution (solid concentration: 0.80%).

Production Example 2-2. Preparation of liquorice extract 618 g of liquorice extract solution was obtained in the same manner as in Production Example 2-1, except that the flowers of Licorice licorice were used instead of the liquorice in Production Example 2-1 (solid content concentration: 0.00). 78%).

Production example 3. Preparation of Juniper Berry Extract To 10 g of dried and crushed juniper berries, 200 g of purified water was added and soaked at 4° C., followed by the addition of 200 g of 1,3-butylene glycol. This was extracted at 4° C. and then filtered to obtain 360 g of a brown transparent filtrate (solid concentration: 1.01%). After that, 240 g of purified water was added to obtain 600 g of juniper berry extract solution (solid concentration: 0.53%).

Production example 4. Preparation of Mulberry Root Extract To 10 g of dried and chopped mulberry root, 200 g of purified water was added and immersed at 4° C., and then 200 g of 1,3-butylene glycol was added. This was extracted at 4° C. and then filtered to obtain 374 g of brown transparent filtrate (solid concentration: 0.51%). Then, 249 g of purified water was added to obtain 623 g of mulberry root extract solution (solid concentration: 0.20%).

Example 1. Preparation of composition After mixing equal amounts of the four extract solutions obtained in Production Examples 1, 2-1 and 3 and 4, insoluble matter was filtered, and 2360 g of a brown transparent extract solution mixed solution was obtained. (0.41% solid content).

Example 2. Preparation of composition After mixing equal amounts of the four extract solutions obtained in Production Examples 1, 2-2, and 3 and 4, insoluble matter was filtered, and 2360 g of a brown transparent extract solution mixed solution was obtained. (0.41% solid content).

Test example 1. Primary skin irritation suppression test 10 subjects (male and female aged 20 to 60) were divided into 2 groups. It was measured with an apparatus (Mexameter (registered trademark) MX18, manufactured by Courage+Khazaka). After that, an aqueous solution containing laureth 5 (10% Polyoxyethylene 5 lauryl ether) known as a surfactant in the test area and the composition of Example 1 (final concentration of 1% as a solution) was used in one group. Semi-occlusive patching was performed for 30 minutes, and the other group was subjected to semi-occlusive patching for 30 minutes using an aqueous solution containing the composition of Example 2 (1% final concentration as a solution). After completion of the semi-occlusive patch, the same semi-occlusive patch was repeated three times with an interval of 30 minutes or longer. The amount of erythema in the test area of each subject was measured by the above-mentioned measuring device, and the average value of the five subjects for each group was calculated as the amount of suppression of primary irritation by subtracting the value immediately after treatment from the initial value. Also, as a comparative control, instead of the composition of Example 1 or the composition of Example 2, 30% butylene glycol (30-BG) and 0.1% dipotassium glycyrrhizinate (GK2) were used. A semi-occlusive patch was applied in the same manner for 30 minutes, and the amount of erythema in the test area was measured using the above measuring device.

The results of Test Example 1 are shown in FIG.
As shown in FIG. 1, the composition according to Example 1 or 2 of the present invention was confirmed to significantly suppress erythema, that is, to suppress skin inflammation, as compared with the control, and the effect was confirmed by glycyrrhizin. It was more pronounced than dipotassium acid. These results also suggest preventive and ameliorative effects on pigmentation caused by inflammation.

Preferred formulation examples of the present invention are shown below.
Formulation example 1. Lotion [Ingredients] Part Olive oil 1.0
Polyoxyethylene (5.5) cetyl alcohol 5.0
Butylparaben 0.1
Composition of Example 1 3.0
Ethanol 5.0
Glycerin 5.0
1,3-butylene glycol 5.0
Potassium hydroxide Appropriate amount Purified water Amount to make the total amount 100 parts Perfume Appropriate amount

Formulation example 2. Lotion A lotion was obtained in the same manner as in Formulation Example 1, except that 3.0 parts of the composition of Example 2 was used instead of 3.0 parts of the composition of Example 1.

Formulation example 3. Emulsion [Ingredients] Part Liquid paraffin 6.0
Hexalane 4.0
Jojoba oil 1.0
Polyoxyethylene (20) sorbitan monostearate 1.0
Lipophilic glyceryl stearate 1.0
Soy lecithin 1.5
Composition of Example 1 3.0
L-ascorbic acid-2-glucoside 2.0
Potassium hydroxide 0.5
Glycerin 3.0
1,3-butylene glycol 2.0
Carboxymethyl cellulose 0.3
Sodium hyaluronate 0.01
Purified water Amount that makes the total amount 100 parts Fragrance Appropriate amount

Formulation example 4. Milky lotion A milky lotion is obtained in the same manner as in Formulation Example 3, except that 2.0 parts of L-ascorbic acid-2-glucoside and 3.0 parts of arbutin are used in place of 0.5 parts of potassium hydroxide. Ta.

Formulation example 5. Milky lotion A milky lotion is prepared in the same manner as in Formulation Example 3, except that 2.0 parts of L-ascorbic acid-2-glucoside and 2.0 parts of tranexamic acid are used instead of 0.5 parts of potassium hydroxide. Obtained.

Formulation example 6. Milky lotion Milky lotion in the same manner as in Formulation Example 3, except that 2.0 parts of L-ascorbic acid-2-glucoside and 3.0 parts of nicotinamide are used instead of 0.5 parts of potassium hydroxide. got

Formulation example 7. Lotion Ingredients Part Composition of Example 1 10.0
Ethanol 10.0
Glycerin 3.0
1,3-butylene glycol 2.0
Methylparaben 0.2
Citric acid 0.1
Sodium citrate 0.3
Carboxyvinyl polymer 0.1
Xanthan gum 0.1
Fragrance Appropriate amount Potassium hydroxide Appropriate amount Purified water Amount to make the total amount 100 parts

Formulation example 8. Essence [ingredient] part ethanol 2.0
Glycerin 5.0
1,3-butylene glycol 5.0
Methylparaben 0.1
Sodium hyaluronate 0.1
Composition of Example 1 5.0
Citric acid 0.3
Sodium citrate 0.6
Purified water Amount that makes the total amount 100 parts

Example 9. Liquid foundation [ingredients] part stearic acid 2.4
Propylene glycol monostearate 2.0
Cetostearyl alcohol 0.2
Liquid Lanolin 2.0
Liquid paraffin 3.0
Isopropyl myristate 8.5
Propylparaben 0.05
Composition of Example 2 5.0
Carboxymethylcellulose sodium 0.2
Bentonite 0.5
Propylene glycol 4.0
Triethanolamine 1.1
Methylparaben 0.1
Purified water Amount to make the total amount 100 parts Titanium oxide 8.0
Talc 4.0
Appropriate amount of coloring pigment

Formulation example 10. Body Shampoo [Ingredients] Part N-lauroylmethylalanine sodium 25.0
Coconut fatty acid potassium liquid (40%) 26.0
Coconut fatty acid diethanolamide 3.0
Methylparaben 0.1
Composition of Example 1 5.0
1,3-butylene glycol 2.0
Purified water Amount that makes the total amount 100 parts

Formulation example 11. Hair restorer [Ingredients] Part dipotassium glycyrrhizinate 0.1
Mononitroguaiacol sodium 0.02
Pyridoxine hydrochloride 0.03
l-menthol 0.8
Tamasakitsutsurafuji root extract 0.3
Brown algae extract 0.3
Panax ginseng extract 0.3
Gentian extract 2.0
Composition of Example 1 3.5
Trimethylglycine 0.5
Lactic acid 0.2
1,3-butylene glycol 10.0
Phenoxyethanol 0.2
Polyoxyethylene hydrogenated castor oil 0.4
L-Arginine Appropriate amount Ethanol 20.0
Purified water Amount that makes the total amount 100 parts

Formulation example 12. Hair Shampoo [Ingredient] Part Sodium N-coconut oil fatty acid methyl taurate 10.0
Sodium polyoxyethylene (3) alkyl ether sulfate 20.0
Lauryldimethylaminoacetate betaine 10.0
Coconut fatty acid diethanolamide 4.0
Methylparaben 0.1
Citric acid 0.1
Composition of Example 1 2.0
1,3-butylene glycol 2.0
Purified water Amount that makes the total amount 100 parts

Example 13. Hair conditioner [Ingredients] Part polyoxyethylene (10) hydrogenated castor oil 1.0
Distearyldimethylammonium chloride 1.5
Stearyltrimethylammonium chloride 2.0
Glyceryl 2-ethylhexanoate 1.0
Cetanol 3.2
Stearyl alcohol 1.0
Methylparaben 0.1
Composition of Example 1 2.0
1,3-butylene glycol 5.0
Purified water Amount that makes the total amount 100 parts

Formulation example 14. Sheet mask A sheet mask is obtained by impregnating a nonwoven fabric with the following ingredients.
Ingredients Part Composition of Example 1 10.0
Ethanol 10.0
Glycerin 3.0
1,3-butylene glycol 2.0
Methylparaben 0.2
Citric acid 0.1
Sodium citrate 0.3
Xanthan gum 1.0
Water-soluble collagen 0.1
Sodium hyaluronate 0.1
Potassium hydroxide Appropriate amount Purified water Amount to make the total amount 100 parts

Claims (2)

(1) Perilla extract of the Labiatae (Lamiaceae) Perilla, (2) Extract of a plant belonging to the Liliaceae family (Hemerocallis), (3) Cupressaceae (Cupressaceae) Juniperus An anti-inflammatory skin external preparation containing a juniper berry extract and (4) an extract of mulberry belonging to the genus Morus of the family Moraceae as active ingredients. (1) Perilla extract of the Labiatae (Lamiaceae) Perilla, (2) Extract of a plant belonging to the Liliaceae family (Hemerocallis), (3) Cupressaceae (Cupressaceae) Juniperus A skin external preparation for preventing pigmentation, containing a juniper berry extract and (4) an extract of mulberry belonging to the genus Morus of the family Moraceae as active ingredients.