JP7425656B2 - drug administration device - Google Patents

Description

TECHNICAL FIELD The present invention relates to a drug administration device.

A syringe (a syringe with a needle) is used to administer medicine to patients. BACKGROUND ART As a method for storing a medicinal solution to be administered to a patient in a syringe, for example, there is a method of sucking out the medicinal solution from an ampoule or a vial in which the medicinal solution is stored. An ampoule is a container that is filled with a drug solution and then sealed by melting the end of the container with heat. When using the drug solution, the neck of the container is broken, a syringe needle is inserted through the broken part, and the drug solution is sucked out. Is required. A vial is a container (bottle) containing a drug solution with a rubber stopper, and when using the drug solution, it is necessary to insert a needle into the rubber stopper and suck out the drug solution.
On the other hand, there is a prefilled syringe, which is stored in a syringe filled with a drug solution in advance. With a prefilled syringe, there is no need to suck out the drug solution from the container in which it is stored before administering the drug solution. However, some prefilled syringes do not have injection needles attached to them, and it is necessary to attach the injection needle when using them.

US Pat. No. 5,300,303 discloses a drug injection device that provides an automatic mechanism for inserting a needle into a drug cartridge and that reduces manual handling of the needle by the user prior to injection. Patent Document 1 includes: a drug cartridge holder fixed to a main body and configured to hold a drug cartridge; a needle carrier supporting a needle and movable in an axial direction relative to the main body; a rotatable cap at the distal end of the device including a first prestressing spring coupled to the carrier, the cap being such that rotational movement thereof releases the first prestressing spring, thereby causing the needle to The carrier is arranged to move axially toward the proximal end of the device.

Special table 2018-535042 publication

However, in the drug injection device of Patent Document 1, the needle (needle carrier) moves in the axial direction with respect to the main body, so that the main body forming the tip of the device and the needle move before and after inserting the needle into the drug cartridge. The positional relationship may change, giving the user a sense of discomfort.
SUMMARY OF THE INVENTION Accordingly, the present invention provides a drug administration tool that allows preparation for administering a drug solution without changing the configuration of the distal end of the drug administration tool.

The following will achieve the above objectives:
(1) A hollow tubular member having a distal end opening having a blade surface and a rear end opening needle portion having a blade surface , a prefilled syringe, and a hollow tubular member having a distal end opening having a blade surface and a rear end opening needle portion having a blade surface; A drug administration device comprising a cylindrical case housing a prefilled syringe,
The hollow tubular member includes a tubular body having the tip opening and the rear opening needle, and a hub attached to an intermediate portion of the tubular body,
The cylindrical case includes a hollow tubular member mounting portion that protrudes inward from the inner surface and has the hub attached thereto, and a side opening provided at the rear end, and further includes a side opening provided at the rear end of the hollow tubular member. The prefilled syringe is housed so that the hollow tubular member mounting part protrudes and is immovable, and the prefilled syringe is housed in the cylindrical case so as to be movable in the direction of the rear end opening needle part of the hollow tubular member. ,
The prefilled syringe includes an outer cylinder having an outer surface protrusion at its rear end, a sealing member that seals the distal end of the outer cylinder and allows the rear end opening needle to penetrate, and an inner cylinder. a gasket member capable of sliding in a liquid-tight state, and a gasket pressing member that can be attached to the gasket member and whose rear part protrudes from the cylindrical case when attached ,
The drug administration device includes a biasing member that contacts the outer cylinder and biases the prefilled syringe toward the rear end open needle portion;
a stopper that is removably inserted into the side opening of the cylindrical case, contacts the outer surface protrusion of the outer cylinder, and restricts movement of the prefilled syringe in the direction of the hollow tubular member;
The stopper includes a base, two extending portions extending forward from the base and facing each other, and a notch formed between the two extending portions and the base for penetrating the main body of the outer cylinder. The cylindrical case includes an engaging portion with the two extension portions, and the stopper is configured to engage the side opening of the cylindrical case when the stopper is attached to the cylindrical case. and the distal end portions of the two extending portions are engaged with the engaging portion of the cylindrical case,
In the drug administration device, after the stopper is detached, the prefilled syringe moves toward the hollow tubular member due to the pressure of the biasing member, and the sealing member of the prefilled syringe is moved by the rear end open needle portion. A drug administration device that is in a penetrating state.

(2) The hollow tubular member includes a tube body having the distal end opening and the rear end opening needle, a hub attached to an intermediate portion of the tube, one end attached to the hub, and a rear end. and an elastic sleeve that is closed and covers the rear end open needle part, and the elastic sleeve is pierceable by the rear end open needle part by being pressed in the direction of the hub (1). ) The drug administration device described in ).
(3) The drug administration device according to (1) or (2) above, wherein the drug administration device includes a cap that covers the tip opening of the hollow tubular member.
(4) The cylindrical case has two side openings facing each other, and one of the side openings of the cylindrical case engages with the base of the stopper, and the cylindrical case has two side openings facing each other. The drug administration device according to any one of (1) to (3) above, wherein the other side opening is the engaging portion that engages with the distal end portions of the two extending portions .
(5) The cylindrical case is configured to close the outer surface of the prefilled syringe after the stopper is removed and the rear end open needle portion of the hollow tubular member penetrates the sealing member of the prefilled syringe. The drug administration device according to any one of (1) to ( 4 ) above, comprising an abutting portion that abuts the tip end face of the side protrusion to restrict movement.
(6) The cylindrical case includes a guide portion that protrudes inward from the inner surface of the cylindrical case and guides sliding of the prefilled syringe at a position corresponding to the cylindrical body of the stored prefilled syringe. The drug administration device according to any one of (1) to ( 5 ) above.
(7) The drug administration device according to any one of (1) to ( 6 ) above, wherein the biasing member is a coil spring in a compressed state.
(8) The drug administration device according to any one of (1) to (7) above, wherein the gasket pressing member is attached to the gasket member .
(9) The drug administration device is removably attached to a side of the gasket pressing member, and the gasket has a distal end portion that can come into contact with the rear end of the cylindrical case when the gasket pressing member moves forward. The drug administration device according to any one of (1) to (8) above, comprising a movement restriction member that restricts movement of the pressing member.
(10) The drug administration device is attached to the distal end of the cylindrical case, is slidable in the distal direction, and covers the distal opening of the hollow tubular member protruding from the cylindrical case. The drug administration device according to any one of (1) to ( 9 ) above, comprising a cylindrical member.
(11) The drug administration device includes a cylindrical member attached to the distal end of the cylindrical case and for enclosing the distal opening of the hollow tubular member protruding from the cylindrical case; and a biasing means for biasing the member in the distal direction, and the cylindrical member is slidable rearward when pressed, the drug administration according to any one of (1) to ( 9 ) above. Ingredients.

The drug administration device of the present invention includes a hollow tubular member having a distal opening and a rear-opening needle, a prefilled syringe, and a cylinder housing the prefilled syringe such that its distal end faces the rear-opening needle of the hollow tubular member. This is a drug administration device consisting of a shaped case. The cylindrical case has a side opening provided on the side surface of the rear end, and further accommodates the hollow tubular member so that it cannot be moved and the tip opening protrudes, and the prefilled syringe is housed within the cylindrical case. The prefilled syringe is housed in a hollow tubular member so as to be movable in the direction of the open needle at the rear end. It includes a sealing member that can be penetrated, and a gasket member that can slide inside the outer cylinder in a liquid-tight state. The drug administration device includes a biasing member that contacts the outer cylinder and biases the prefilled syringe toward the rear end opening needle, and a biasing member that is removably inserted into the side opening of the cylindrical case and that protrudes from the outer surface of the outer cylinder. and a stopper that comes into contact with the prefilled syringe and restricts movement of the prefilled syringe in the direction of the hollow tubular member. In the drug administration device, after the stopper is removed, the prefilled syringe moves toward the hollow tubular member due to the pressure of the biasing member, and the sealing member of the prefilled syringe is penetrated by the rear end open needle portion. There is.

In this drug administration device, when the stopper is removed, the prefilled syringe is pressed by the biasing member and moves toward the hollow tubular member, and the sealing member of the prefilled syringe is moved by the open needle at the rear end of the hollow tubular member. It is pierced and the two are connected. Therefore, preparation for administering the drug solution is extremely easy.
Further, the hollow tubular member is immovably housed in the cylindrical case, and a distal end portion including the distal opening of the hollow tubular member protrudes from the distal end of the cylindrical case. Therefore, the positional relationship between the distal end opening and the distal end of the cylindrical case does not change throughout preparation for administration, so that the user does not feel uncomfortable.

FIG. 1 is a front view of one embodiment of the drug administration device of the present invention. FIG. 2 is a perspective view of the drug administration device shown in FIG. 1. FIG. 3 is an explanatory diagram of constituent members used in the drug administration device shown in FIG. 1. FIG. 4 is a longitudinal sectional view of the drug administration device shown in FIG. 1. FIG. 5 is a cross-sectional view taken along line AA in FIG. 4. FIG. 6 is a front view of the cylindrical case used in the drug administration device shown in FIG. 1 in an exploded state. FIG. 7 is a bottom view of the cylindrical case shown in FIG. 6 in an exploded state. FIG. 8 is an inner view of the constituent members of the cylindrical case shown in FIG. 6. FIG. 9 is a front view of the stopper used in the drug administration device shown in FIG. 1. FIG. 10 is a plan view of the stopper shown in FIG. 9. FIG. 11 is a perspective view of the stopper shown in FIG. 9. FIG. 12 is an explanatory diagram for explaining the action of the drug administration device of the present invention. FIG. 13 is a longitudinal sectional view of the drug administration device shown in FIG. 12. FIG. 14 is a sectional view taken along the line BB in FIG. 12. FIG. 15 is a front view of a drug administration device according to another embodiment of the present invention. FIG. 16 is a front view of a drug administration device according to another embodiment of the present invention. FIG. 17 is a front view of a gasket pressing member movement distance regulating member used in the drug administration tool shown in FIG. 16. FIG. 18 is a right side view of the gasket pressing member movement distance regulating member shown in FIG. 17. FIG. 19 is a plan view of the gasket pressing member movement distance regulating member shown in FIG. 17. FIG. 20 is a sectional view taken along line CC in FIG. 17. FIG. 21 is a front view of a drug administration device according to another embodiment of the present invention. FIG. 22 is a right side view of the gasket pressing member movement distance regulating member used in the drug administration tool shown in FIG. 21. FIG. 23 is a bottom view of the gasket pressing member movement distance regulating member used in the drug administration device shown in FIG. 21. FIG. 24 is a longitudinal sectional view of a drug administration device according to another embodiment of the present invention. FIG. 25 is a front view of a drug administration device according to another embodiment of the present invention. FIG. 26 is an explanatory diagram for explaining the action of the drug administration tool shown in FIG. 25. FIG. 27 is a front view of a drug administration device according to another embodiment of the present invention. FIG. 28 is a front view of a drug administration device according to another embodiment of the present invention.

The drug administration device of the present invention will be explained using examples shown in the drawings.
The drug administration device 1 of the present invention includes a hollow tubular member 3 having a distal opening 31a and a rear open needle 31b, a prefilled syringe 2, and a distal end facing the rear open needle 31b of the hollow tubular member 3. This drug administration device consists of a cylindrical case 4 that houses a prefilled syringe 2. The cylindrical case 4 accommodates the hollow tubular member 3 in such a way that it is immovable and the tip portion including the tip opening 31a protrudes, and the prefilled syringe 2 is movable in the direction of the hollow tubular member 3 within the cylindrical case 4. It is further provided with side openings 43a and 43b provided at the rear end.
The prefilled syringe 2 includes an outer cylinder 21 having an outer surface protrusion 26 at the rear end, and a seal that seals the tip of the outer cylinder 21 and allows the rear end open needle part 31b of the hollow tubular member 3 to penetrate. It includes a member 24 and a gasket member 22 that can slide inside the outer cylinder 21 in a liquid-tight state.

The drug administration device 1 includes a biasing member 11 that contacts the outer cylinder 21 and biases the prefilled syringe 2 toward the rear end open needle portion 31b, and a biasing member 11 that can be detached from the side openings 43a and 43b of the cylindrical case 4. The stopper 5 is inserted and comes into contact with the outer surface protrusion 26 of the outer cylinder 21 to restrict movement of the prefilled syringe 2 in the direction of the hollow tubular member 3 . In the drug administration device 1, after the stopper 5 is removed, the prefilled syringe 2 is moved toward the hollow tubular member 3 by the pressure of the biasing member 11, and the sealing member 24 of the prefilled syringe 2 is moved by the rear end open needle portion 31b. It is in a penetrating state.
In other words, the biasing member 11 presses the prefilled syringe so that the sealing member 24 of the prefilled syringe 2 is pierced by the rear end open needle portion 31b of the hollow tubular member 3 after the stopper 5 is removed. It has become.

The drug administration device 1 of the embodiment shown in the drawings includes a prefilled syringe 2, a hollow tubular member 3, a cylindrical case 4, a stopper 5, and a biasing member 11, as shown in FIGS. 1 to 5. ing.
As shown in FIGS. 3 and 4, the prefilled syringe 2 includes an outer cylinder 21, a sealing member (seal cap) 24 attached to the nozzle portion of the outer cylinder 21, and a sealing member (seal cap) 24 that is slidably housed within the outer cylinder. The gasket member 22 includes a gasket member 22 and a gasket pressing member 23 attached to the gasket member 22.

The outer cylinder 21 is a cylindrical body made of a transparent or translucent material, preferably a material with low oxygen permeability and water vapor permeability. The outer cylinder 21 includes an outer cylinder main body, a nozzle part 21a provided on the front end side of the outer cylinder main body, and an outer surface protrusion 26 provided on the rear end side of the outer cylinder main body. As shown in FIGS. 3 and 4, the outer surface protrusion 26 is preferably a flat annular protrusion that is formed to protrude in the vertical direction from the entire circumference of the rear end of the outer cylinder main body. In this embodiment, the outer surface protrusion 26 includes opposing widened portions as shown in FIG.

The nozzle portion 21a is located at the tip of the outer cylinder 21, has an opening at the tip for discharging the chemical liquid, etc. inside the outer cylinder, and is formed to taper in diameter toward the tip. The nozzle portion 21a includes a sealing member mounting portion.
Examples of materials for forming the outer cylinder 21 include polypropylene, polyethylene, polystyrene, polyamide, polycarbonate, polyvinyl chloride, poly-(4-methylpentene-1), acrylic resin, acrylonitrile-butadiene-styrene copolymer, and polyethylene terephthalate. Among them, resins such as polypropylene and cyclic polyolefin are preferred because they are easy to mold and have heat resistance.

As shown in FIGS. 3 and 4, the sealing member 24 includes a cylindrical sealing member body and a sealing member 27 housed within the sealing member body. The sealing member 24 includes a nozzle housing portion and a sealing member side outer cylinder mounting portion 24a. In this embodiment, the cylindrical sealing member main body is a cylindrical member with openings at one end and the other end, and includes an opening 24b having a tapered diameter on the distal end side for attaching the rear end opening needle portion 31b. ing. A seal member 27 is housed behind this opening 24b. One end of the seal cap is closed by the seal member 27.

The seal member 27 is for liquid-tightly sealing the tip opening of the nozzle portion. The nozzle portion 21a is liquid-tightly sealed by the abutment of the nozzle portion tip opening against the sealing member 27. Further, the seal member 27 is made of an elastic material that can be pierced by the rear end open needle portion 31b.
Examples of the material for forming the seal member 27 include natural rubber, isoprene rubber, butadiene rubber, fluorine rubber, synthetic rubber such as silicone rubber, styrene elastomer such as SBS elastomer and SEBS elastomer, and ethylene-α-olefin copolymer. It is preferable to use a thermoplastic elastomer such as a polyolefin elastomer.

Examples of materials for forming the sealing member include polypropylene, polyethylene, polystyrene, polyamide, polycarbonate, polyvinyl chloride, poly-(4-methylpentene-1), acrylic resin, acrylonitrile-butadiene-styrene copolymer, and polyethylene terephthalate. Among them, resins such as polypropylene and cyclic polyolefin are preferred because they are easy to mold and have heat resistance.

As shown in FIG. 4, the gasket member 22 includes a main body extending with approximately the same outer diameter and a plurality of annular ribs provided on the main body, and these ribs are in liquid-tight contact with the inner surface of the outer cylinder 21. do.
Materials for forming the gasket member 22 include elastic rubber (for example, butyl rubber, latex rubber, silicone rubber, etc.), synthetic resin (for example, styrene elastomer such as SBS elastomer and SEBS elastomer, and ethylene-α olefin copolymer elastomer). It is preferable to use olefin elastomers such as

In the drug administration device 1 of this embodiment, the gasket member 22 preferably includes a gasket pressing portion whose rear portion protrudes from the cylindrical case. The drug administration device 1 of this embodiment includes a gasket pressing member 23 that can be attached to a gasket member 22 and whose rear portion protrudes from the cylindrical case when attached. Note that the gasket pressing portion may be integrated with the gasket member or may be fixed to the gasket member.

Note that the gasket pressing member (plunger) 23 may be attached after the drug administration device 1 is assembled. In this embodiment, the gasket member 22 is provided with a recess that extends inward from its rear end, and this recess has a female thread shape and is formed on the outer surface of the protrusion formed at the tip of the gasket pressing member 23. It can be screwed into the formed male threaded part. By screwing the two together, the gasket pressing member 23 does not separate from the gasket member 22. The above-mentioned types of gasket members and gasket pressing members can be installed after the drug administration device 1 is assembled.
The gasket pressing member 23 has a cylindrical protrusion at its tip, and a male thread is formed on the outer surface of the protrusion. Further, the gasket pressing member 23 includes a main body portion having a cross-shaped cross section and extending in the axial direction, a pressing disk portion provided at the rear end portion, and a rib provided midway through the main body portion.

The prefilled syringe 2 is filled with a drug (medicinal solution) 25 . Drugs (medicinal solutions) 25 include epinephrine injection preparations (vasoconstrictors) that are anti-anaphylactic shock drugs, antiarrhythmic agents (e.g., lidocaine), anticholinergic agents (e.g., atropine), and anticonvulsants (e.g., diazepam). , rocuronium bromide injection preparations, nitroglycerin, physiological saline and other emergency drugs, cyclosporine, benzodiazepines, high concentration sodium chloride injections, vitamin preparations, minerals, antibiotics and other medicines, vitamin preparations (general (vitamin preparations), various amino acids, antithrombotic agents such as heparin, insulin, antitumor agents, analgesics, cardiac agents, intravenous anesthetics, antiparkinsonian agents, ulcer treatment agents, adrenocortical hormone agents, arrhythmia agents, correction agents Possible agents include electrolytes, antiviral agents, and immunostimulants.

As shown in FIGS. 3 and 4, the hollow tubular member 3 includes a tubular body 31 having a distal end opening 31a and a rear end opening needle portion 31b, and a hub 32 attached to an intermediate portion of the tubular body 31. ing. In this embodiment, as shown in FIGS. 3 and 4, the hollow tubular member 3 has a distal end opening having a blade surface, and a rear end opening needle portion also has a blade surface. This makes it a so-called double-ended needle.
Furthermore, the hollow tubular member 3 of this embodiment includes an elastic sleeve 33 that is attached to the hub 32 at one end, closed at the rear end, and encloses the rear-end open needle portion 31b. Furthermore, the hollow tubular member 3 of this embodiment has a rear end attached to the hub 32, a distal end closed, and a hollow tubular member cap 34 that covers the distal opening 31a.

Preferably, the drug administration device 1 of the present invention includes a cap that encloses the distal end opening 31a of the hollow tubular member 3. In this embodiment, the hollow tubular member cap 34 constitutes a cap that encloses the distal end opening 31a. Note that the cap may be one that is attached to the tip of the cylindrical case 4 and covers the tip opening 31a of the hollow tubular member 3.
The elastic sleeve 33 is elastically deformed by being pressed in the direction of the hub 32, and can be penetrated by the rear end open needle part 31b. stand out.

The hollow tubular member 3 includes a hub 32 that is penetrated by the tubular body 31 near the middle of the tubular body 31 (on the rear end open needle side from the center). The hollow tubular member 3 is attached to the hollow tubular member attachment portion 47 of the cylindrical case 4 at the hub 32 portion, with axial movement and rotation being restricted. When the hollow tubular member 3 is attached to the cylindrical case 4, it protrudes by a predetermined length from the distal end of the cylindrical case 4 in the distal direction, as shown in FIG. The hub 32 includes an outer surface protrusion 32a that is accommodated in the recess 47a of the hollow tubular member mounting portion 47 of the cylindrical case 4, and an annular projection 32b that engages with the rear end surface of the rear rib recess 47b of the hollow tubular member mounting portion 47. It is equipped with

A hollow tubular member cap 34 for protecting the distal end opening 31a of the tube body 31 is detachably attached to the hollow tubular member 3. The cap 34 of this embodiment is made of a transparent material or a semi-transparent material, so that when the cap 34 is attached to the hub 32, the protrusion of the tube body 31 including the tip opening 31a can be visually recognized. can. As the transparent material and semi-transparent material forming the cap 34, polyolefins such as polyethylene and polypropylene, polycarbonate, polystyrene, etc. can be suitably used.

The hollow tubular member 3 has an elastic sleeve 33 attached to the rear end open needle portion side (rear end portion) of the hub 32 to cover the rear end open needle portion 31b of the tubular body 31. This elastic sleeve 33 is folded into a bellows shape between the hub 32 and the prefilled syringe when the prefilled syringe is inserted into the sealing member. The elastic sleeve 33 may be made of synthetic rubber such as natural rubber, isoprene rubber, butadiene rubber, fluororubber, or silicone rubber, styrene elastomer such as SBS elastomer or SEBS elastomer, or polyolefin elastomer such as ethylene-α-olefin copolymer. It is preferable to use a thermoplastic elastomer or the like.

As shown in FIGS. 1 to 8, the cylindrical case 4 is formed by a connected body of a first case member 41 and a second case member 41, and has an elliptical cylindrical shape.
The first case member 41 and the second case member 41 are semi-cylindrical members, and have a plurality of protrusions 49a and a recess 49b on the inner peripheral edge that serves as the abutting part, as shown in FIG. , by engaging the two, they form a connected body.

The cylindrical case 4 has an elliptical cylindrical shape that can accommodate the outer surface protrusion 26 of the prefilled syringe 2. The cylindrical case 4 includes a hollow tubular member storage part and a prefilled syringe storage part inside, and a hollow tubular member mounting part 47 that protrudes inward from the inner surface and can come into contact with the outer surface of the outer cylinder 21 of the prefilled syringe 2. It includes guide parts 14a and 14b that guide the sliding movement of the prefilled syringe 2. The guide parts 14a and 14b are formed to protrude inward from the inner surface of the cylindrical case 4 at a position corresponding to the cylindrical body of the stored prefilled syringe 2, and their inner shape matches the outer shape of the prefilled syringe 2. It is preferable that the size is slightly larger than that of the actual size.

The cylindrical case 4 includes an engagement portion with a stopper 5, which will be described later. In this embodiment, the engagement portion of the cylindrical case with the stopper 5 is formed by two side openings (through openings) 43a and 43b formed to face each other. In addition, the engaging part with the stopper 5 may have only one side opening and a recess provided at a position facing the opening and which can engage with the stopper (one end), or may have only one side opening. The inner surface of the cylindrical case facing the opening and slightly toward the distal end may be provided with inner ribs that can be engaged with the stopper (one end) and do not impede movement of the prefilled syringe. .

When the prefilled syringe is locked by the stopper 5, the cylindrical case 4 includes a first storage section 45 that stores the outer surface protrusion 26 of the prefilled syringe, the biasing member 11 in a compressed state, and the stopper 5, and the stopper 5. After the prefilled syringe 5 is removed and the prefilled syringe moves forward, a second storage part 46 is provided to accommodate the outer surface protrusion 26 of the prefilled syringe. Further, the second storage portion stores the extended tip end portion of the biasing member.

Further, after the stopper 5 is removed and the sealing member 24 of the prefilled syringe 2 is pierced by the rear end open needle portion 31b of the hollow tubular member 3, the cylindrical case 4 is attached to the outer surface of the prefilled syringe 2. A contact portion 46a is provided that comes into contact with the tip end surface of the protrusion 26 to restrict movement. In this embodiment, the movement restricting abutment portion 46a is formed by the distal end surface of the second storage portion 46.

Further, as shown in FIG. 4, the cylindrical case 4 includes slit-shaped side openings (through openings) 43a and 43b provided at the rear end. The stopper 5 is inserted so as to pass through the side openings (through openings) 43a, 43b. The stopper 5 is removable. The rear surface of the stopper 5 comes into contact with the front surface of the outer surface protrusion 26 of the prefilled syringe 2, and restricts the forward movement of the prefilled syringe 2.

It is preferable that the cylindrical case 4 has transparency or translucency so that the hollow tubular member 3 and prefilled syringe 2 housed therein can be visually recognized. Materials for forming the cylindrical case 4 include transparent or translucent resins such as polypropylene, polyethylene, polystyrene, polyamide, polycarbonate, polyvinyl chloride, poly(4-methylpentene-1), acrylic resin, Examples include various resins such as acrylonitrile-butadiene-styrene copolymers, polyesters such as polyethylene terephthalate, and cyclic polyolefins.

Further, as shown in FIG. 4, the biasing member 11 housed in the first storage portion of the cylindrical case 4 is connected to the rear end portion 48 of the cylindrical case 4 and the rear surface of the outer surface protrusion 26 of the prefilled syringe 2. It is in a compressed state depending on the time. In this embodiment, a coil spring is used as the biasing member 11, and the gasket pressing member 23 of the prefilled syringe 2 passes through the biasing member 11. Further, in this embodiment, the rear end portion of the biasing member 11 is housed and fixed within an annular recess provided at the rear end portion of the cylindrical case 4.

As shown in FIGS. 4, 5, and 9 to 11, the stopper 5 includes a base 54, two extending portions 52, 53 extending forward from the base 54 and facing each other, and two extending portions 52, 53. A notch 55 is formed between the outer cylinder 21 and the base 54 for penetrating the main body of the outer cylinder 21, and a grip 51 is provided at the rear of the base 54.

The cylindrical case 4 has two engaging parts 52 and 53, and when the stopper 5 is attached to the cylindrical case 4, the base 54 is connected to one side opening of the cylindrical case 4. 43b, and the tips of the two extending portions 52, 53 are engaged with the engaging portion of the cylindrical case 4. Further, the base end portion of the base portion 54 protrudes from the side opening of the cylindrical case.
Specifically, the grip portion 51 is a bulge. In this embodiment, the stopper 5 has a U-shape, passes through the cylindrical case 4, sandwiches the outer cylinder 21 of the prefilled syringe 2 inside the U-shape, and has two side openings. By inserting it through the syringe, the axial movement of the prefilled syringe is suppressed.

As shown in FIGS. 4 and 5, when the stopper 5 is attached to the cylindrical case 4, the grip part 51 is attached to the side openings (through openings , one opening 43b, the other opening 43b, The opening 43a projects from one opening 43b of the opening 43a), and the tips of the two extensions 52 and 53 project from the other opening 43a of the side opening (through opening). . Further, as shown in FIGS. 4 and 5, the bottom surface of the base 54 and the two extensions 52 and 53 of the stopper 5 abuts the top surface of the outer surface protrusion 26 of the prefilled syringe 2, and the base 54 of the stopper 5 The upper surface abuts the upper edge of one opening 43b of the cylindrical case 4, and the upper surface of the two extensions 52, 53 abuts the upper edge of the other opening 43a of the cylindrical case 4. are in contact with each other. As a result, the stopper 5 is inserted between the upper edges of the openings 43a and 43b of the cylindrical case 4 and the outer surface protrusion 26 of the prefilled syringe 2 within the side opening (through opening) of the cylindrical case 4. , which is clamped and does not easily come off.

Next, the functions of the drug administration device 1 according to the embodiment of the present invention will be explained.
In the drug administration device 1 of the present invention, as shown in FIGS. 1, 2, and 4, when the stopper is attached, the distal end portion including the distal opening 31a of the hollow tubular member 3 is disposed at the distal end of the cylindrical case 4. The rear part of the gasket pressing member 23, which protrudes from the opening 40 and is attached to the gasket member 22, protrudes from the rear end of the cylindrical case 4. The length of the protrusion of the distal end of the hollow tubular member 3 including the distal end opening 31a from the distal end of the cylindrical case 4 is preferably 2 to 20 mm, particularly preferably 12 to 17 mm.

Then, as shown in FIG. 12, when the stopper 5 is detached (removed) from the drug administration tool 1, the state in which the stopper 5 locks the outer surface protrusion 26 of the prefilled syringe 2 is released. As a result, the outer surface protrusion 26 of the prefilled syringe 2 is pressed from the rear by the urging member 11, and the prefilled syringe 2 moves forward (in the direction of the hollow tubular member 3).

The prefilled syringe 2 (specifically, the sealing member 24) and the hollow tubular member 3 of this embodiment are housed in the cylindrical case 4 so that their central axes are substantially the same. Further, even when the prefilled syringe 2 is moved by the pressure of the biasing member 11, the central axis of the prefilled syringe 2 (specifically, the sealing member 24) is shaped like a hollow tube by the guide portions 14a, 14b, etc. The member 3 slides forward (in the direction of the hollow tubular member 3) while maintaining substantially the same central axis.

The biasing force of the biasing member 11 on the prefilled syringe 2 is such that at least after the stopper 5 is removed, the sealing member 27 of the sealing member 24 of the prefilled syringe 2 is pierced by the rear end open needle portion 31b of the hollow tubular member 3. The prefilled syringe is pressed so that Further, the biasing force of the prefilled syringe 2 by the biasing member 11 is applied until the outer surface protrusion 26 of the prefilled syringe 2 comes into contact with the movement regulating abutment part 46a of the second storage part 46 of the cylindrical case 4. 2 can be moved forward (in the direction of the hollow tubular member 3), and furthermore, the outer surface protrusion 26 of the prefilled syringe 2 comes into contact with the movement-restricting contact part 46a of the second storage part 46 of the cylindrical case 4. It is preferable that the prefilled syringe 2 is further pressed later.

The biasing force of the prefilled syringe 2 by the biasing member 11 varies depending on the piercing resistance of the sealing member 27 by the rear end open needle portion 31b of the hollow tubular member 3, but is preferably 2.7N to 4.7N. It is preferably 3.0N to 4.3N, more preferably 3.4N to 4.0N. Further, the thickness of the sealing member 27 is preferably 0.7 to 1.5 mm, particularly preferably 0.8 to 1.2 mm. Further, the distance between the tip of the rear open needle portion 31b of the hollow tubular member 3 and the upper surface of the seal member 27 is preferably 2 to 6 mm, particularly preferably 3 to 5 mm. Further, the distance until the entire rear end open needle portion 31b of the hollow tubular member 3 penetrates the seal member 27 (in other words, the distance moved by the biasing member toward the distal end of the prefilled syringe in the cylindrical case) is , 4 to 10 mm, particularly preferably 5 to 8 mm.

The coil spring used in the biasing member 11 is preferably a spring that has a set spring constant of 0.1 N/mm or more and can be compressed by 40 mm or more. Further, it is preferable that the inner diameter of the spring is 10 mm to 20 mm, the height when the spring is compressed is 5 mm or less, and the height when the spring is released is 40 mm to less than 50 mm.

Next, the operation of the drug administration device 1 according to the embodiment of the present invention will be explained.
When the stopper 5 is detached (removed) from the drug administration device 1 from the stopper-attached state shown in FIGS. 1, 2, and 4, as shown in FIG. The locked state is released, and the outer surface protrusion 26 of the prefilled syringe 2 is pressed from the rear by the urging member 11, and the prefilled syringe 2 moves forward (in the direction of the hollow tubular member 3).

Then, as shown in FIG. 12, the sealing member 27 of the sealing member 24 of the prefilled syringe 2 that has moved forward is pierced by the rear end open needle portion 31b of the hollow tubular member 3. Thereby, the inside of the tube body 21 of the hollow tubular member 3 communicates with the inside of the prefilled syringe 2.

Further, the moved outer surface protrusion 26 enters into the second storage part 46 of the cylindrical case 4 and comes into contact with the contact part 46a of the second storage part 46, as shown in FIGS. 13 and 14. contact, and further forward movement is restricted. Then, in a state where the sealing member 24 of the prefilled syringe 2 shown in FIGS. 12 and 13 is pierced by the rear end open needle portion 31b of the hollow tubular member 3, the pressing operation portion 23a of the gasket pressing member 23 is pressed. The rear side portion thereof is in a state of protruding from the cylindrical case 4 by a predetermined length.

Then, by removing the cap 34 of the hollow tubular member 3, preparations for drug administration are completed. Further, the gasket pressing member 23 can be pressed until the pressing operation portion 23a comes into contact with the rear end surface of the cylindrical case 4, and the medicine can be discharged by the amount of movement of the gasket pressing member 23.
The movable distance of the gasket pressing member 23 (the distance between the rear end surface of the cylindrical case 4 and the distal end surface of the pressing operation part 23a of the gasket pressing member 23) varies depending on the capacity of the prefilled syringe used, the drug to be administered, etc. However, it is preferably 4 to 10 mm, more preferably 5 to 7 mm, and particularly preferably 5.5 to 6.5 mm.

Next, a drug administration device 1a according to another embodiment of the present invention shown in FIG. 15 will be described.
The basic structure of the drug administration device 1a of this embodiment is the same as the drug administration device 1 described above, and the only difference is that it includes a cap connecting member 35.
In the drug administration device 1a of this embodiment, similarly to the drug administration device 1 described above, the hollow tubular member 3 includes a tube body 31 having a tip opening 31a and a rear end opening needle portion 31b, and an intermediate portion of the tube body 31. A hollow tubular member cap 34 whose rear end is attached to the hub 32, whose distal end is closed, and covers the distal opening 31a is provided.

The drug administration device 1a includes a cap connection member 35 having a connection portion 35a with a hollow tubular member cap 34 and a cylindrical case attachment portion 35b. The cylindrical case mounting portion 35b is a short cylindrical portion having an inner surface shape corresponding to the outer surface shape of the tip of the cylindrical case 4. The cap connecting portion 35a is a short, small-diameter cylindrical portion having an inner surface shape corresponding to the outer surface shape of the side portion of the hollow tubular member cap 34.

Further, the cap connecting portion 35a includes a connecting portion 35c that connects the cylindrical case mounting portion 35b and the cap connecting portion 35a. The cylindrical case mounting portion 35b of the cap connecting portion 35a is removable from the cylindrical case 4, and the cap connecting portion 35a is substantially non-removable from the hollow tubular member cap 34. . Further, it is preferable that the connecting portion 35c seals the tip opening 40 of the cylindrical case 4.
In the drug administration device 1a of this embodiment, when the cap connecting member 35 is detached from the cylindrical case 4, the hollow tubular member cap 34 is also detached from the hollow tubular member 3 at the same time. The detachment work is easy.

Next, a drug administration device 1b according to another embodiment of the present invention shown in FIG. 16 will be described.
FIG. 17 is a front view of a gasket pressing member movement distance regulating member used in the drug administration tool shown in FIG. 16. FIG. 18 is a right side view of the gasket pressing member movement distance regulating member shown in FIG. 17. FIG. 19 is a plan view of the gasket pressing member movement distance regulating member shown in FIG. 17. FIG. 20 is a sectional view taken along line CC in FIG. 17.

The drug administration device of the present invention is removably attached to the side of a gasket pressing member (or gasket pressing part), and when the gasket pressing member (or gasket pressing part) moves forward, the distal end part is attached to the cylindrical case. It may be provided with a movement restriction member that restricts movement of a gasket pressing member (or gasket pressing portion) that can come into contact with the rear end.
The drug administration device 1b of this embodiment includes a gasket pressing member movement regulating member 9. The basic configuration of the drug administration device 1b of this embodiment is the same as the drug administration device 1 described above, and the differences are the protruding length of the gasket pressing member 23 from the rear end of the cylindrical case 4, and the gasket pressing member 23. The only difference is that the gasket pressing member movement regulating member 9 is detachably attached to the member 23.

The drug administration tool 1b of this embodiment is detachably attached to the side of the gasket pressing member 23, and the distal end is spaced apart from the rear end of the cylindrical case 4, and when the gasket pressing member 23 moves forward, A gasket pressing member movement regulating member 9 is provided, the tip of which can come into contact with the rear end of the cylindrical case 4. In this embodiment, the gasket pressing member movement regulating member 9 is a gasket pressing member movement distance regulating member 9.

The gasket pressing member movement regulating member is removably attached to the side of the gasket pressing member 23, has a distal end close to the rear end of the cylindrical case 4, and prevents the gasket pressing member 23 from moving forward. Therefore, the tip portion may be able to come into contact with the rear end of the cylindrical case 4. With such a device, it is possible to prevent the drug administration device from inadvertently administering the drug after the stopper 5 is removed and the drug administration device becomes ready for administration.

As shown in FIGS. 17 to 20, the gasket pressing member movement distance regulating member 9 includes a gasket pressing member mounting portion 91, a gripping portion 92, a front end side contact portion 93, and a rear end side contact portion 94. As shown in FIGS. 19 and 20, the gasket pressing member mounting portion 91 is an axially penetrating plate that is removably mounted on one flat plate portion of the axially extending main body portion of the gasket pressing member 23 that has a cross-shaped cross section. A recessed portion 91a is provided.

The gripping part 92 is a flat plate-like part that extends in the lateral direction from the side of the gasket pressing member mounting part 91, and is used to grip and hold the gasket pressing member movement distance regulating member 9 when removing it from the gasket pressing member 23. It can be used as a part.

The distal end contact portion 93 restricts further movement of the gasket pressing member 23 toward the distal end after contact with the rear end surface of the cylindrical case 4 . The distal end contact portion 93 is capable of contacting the rear end surface of the cylindrical case 4 after the gasket pressing member moves. In this embodiment, the distal end contact portion 93 has a flat plate shape connected to the distal end of the gasket pressing member mounting portion 91. As shown in FIG. 19, the distal end contact portion 94 is preferably semicircular.

The rear end contact portion 94 is in contact with the distal end surface of the pressing operation portion 23a of the gasket pressing member 23, and is for regulating rearward movement of the gasket pressing member movement distance regulating member 9. In this embodiment, the rear end side abutting portion 94 is in the form of a flat plate connected to the rear end of the gasket pressing member mounting portion 91 . As shown in FIG. 20, the rear end side contact portion 94 is preferably semicircular.

In the drug administration tool 1b of this embodiment, by pressing the pressing operation part 23a of the gasket pressing member 23, the distal end contact part 93 of the gasket pressing member movement distance regulating member 9 is brought into contact with the rear end surface of the cylindrical case 4. You can only move until you touch it. Therefore, depending on the movable distance, a predetermined amount of medicine can be ejected (administered), or it can be made impossible to actually administer medicine. In the illustrated example, the distal end contact portion 93 is spaced apart from the rear end surface of the cylindrical case 4 by a predetermined distance, and the gasket pressing member 23 can be moved by the distance, thereby ejecting a predetermined amount of medicine. (administration) is possible.

Furthermore, when it is necessary to eject (administer) the drug, the gasket pressing member movement distance regulating member 9 is removed from the gasket pressing member and the pressing operation portion 23a of the gasket pressing member 23 is pressed. The pressing operation part 23a can be moved until it comes into contact with the rear end surface of the cylindrical case 4, and an additional ejection (additional administration) of a predetermined amount of medicine can be performed.

Next, a drug administration device 1c according to another embodiment of the present invention shown in FIG. 21 will be described.
FIG. 22 is a right side view of the gasket pressing member movement distance regulating member used in the drug administration tool shown in FIG. 21. FIG. 23 is a bottom view of the gasket pressing member movement distance regulating member used in the drug administration device shown in FIG. 21.

The basic structure of the drug administration device 1c of this embodiment is the same as the drug administration device 1 described above, and the difference is in the protruding length of the gasket pressing member 23 from the rear end of the cylindrical case 4 and the length of the gasket pressing member 23. The only difference is that the first gasket pressing member movement distance regulating member 9a and the second gasket pressing member movement distance regulating member 9b are detachably attached to the gasket pressing member.

The basic structure of this drug administration tool 1c is the same as the drug administration tool 1 described above, and the difference is the length of the gasket pressing member 23 protruding from the rear end of the cylindrical case 4, and the ability to be attached to and detached from the gasket pressing member 23. The only difference is that a first gasket pressing member movement distance regulating member 9a and a second gasket pressing member movement distance regulating member 9b are provided.

The drug administration device 1c of this embodiment is detachably attached to the side of the gasket pressing member 23, and the distal end is spaced apart from the rear end of the cylindrical case 4, and when the gasket pressing member 23 moves forward, A first gasket pressing member movement distance regulating member 9a and a second gasket pressing member movement distance regulating member 9b are provided, the distal end of which can come into contact with the rear end of the cylindrical case 4.
The first gasket pressing member movement distance regulating member 9a and the second gasket pressing member movement distance regulating member 9b of this embodiment are the same as the gasket pressing member moving distance regulating member 9 shown in FIGS. 17 to 20. It includes a mounting part 91, a gripping part 92, a distal end contacting part 93, and a rear end contacting part 94.

The second gasket pressing member movement distance regulating member 9b is provided with a protrusion 95 provided on the rear end surface of the rear end side abutting portion 94, as shown in FIGS. 21 to 23. In the state in which the first gasket pressing member movement distance regulating member 9a and the second gasket pressing member movement distance regulating member 9b are attached to the gasket pressing member 23, the second gasket pressing member movement distance regulating member 9b on the rear end side is It is intended to restrict withdrawal.

When the first gasket pressing member movement distance regulating member 9a is pulled out in the side direction to remove it from the state shown in FIG. However, the second gasket pressing member comes into contact with the protrusion 95 of the movement distance regulating member 9b, has a high detachment resistance, and regulates detachment. Therefore, in the drug administration tool 1c of this embodiment, the gasket pressing member movement distance regulating member is removed in the order of the second gasket pressing member movement distance regulating member 9b and the first gasket pressing member movement distance regulating member 9a.

In the drug administration tool 1c of this embodiment, by pressing the pressing operation part 23a of the gasket pressing member 23, the distal end side abutting part 93 of the second gasket pressing member movement distance regulating member 9b located on the distal side is moved into the cylinder. It can be moved until it comes into contact with the rear end surface of the shaped case 4, and a predetermined amount of medicine can be ejected (administered). Further, when ejection (administration) of the drug is required, the second gasket pressing member movement distance regulating member 9b is removed from the gasket pressing member and the pressing operation portion 23a of the gasket pressing member 23 is pressed. The gasket pressing member can be moved until the distal end contact portion 93 of the moving distance regulating member 9a comes into contact with the rear end surface of the cylindrical case 4, and a predetermined amount of medicine can be ejected (administered).

Further, when ejection (administration) of the drug is required, the first gasket pressing member movement distance regulating member 9a is removed from the gasket pressing member and the pressing operation portion 23a of the gasket pressing member 23 is pressed, thereby pressing the gasket. The pressing operation portion 23a of the member can be moved until it comes into contact with the rear end surface of the cylindrical case 4, and a predetermined amount of medicine can be additionally ejected (additional administration).

Next, a drug administration device 1d according to another embodiment of the present invention shown in FIG. 24 will be described.
The basic configuration of the drug administration device 1d of this embodiment is the same as the drug administration device 1 described above, and the only difference is the form of the biasing member storage section.
In the drug administration device 1d of this embodiment, the rear end of the cylindrical case 4 is provided with a cylindrical urging member storage part that communicates with the first storage part 45 and has a smaller diameter than the first storage part 45. ing. The biasing member 11 is configured as a biasing member storage portion, and its rear end portion is not fixed to the cylindrical case 4.

Next, a drug administration device 1e according to another embodiment of the present invention shown in FIG. 25 will be described.
FIG. 26 is an explanatory diagram for explaining the action of the drug administration tool shown in FIG. 25.
The basic structure of the drug administration device 1e of this embodiment is the same as the drug administration device 1 described above, and the difference is that the drug administration device 1e of this embodiment has the same structure as the drug administration device 1 described above. The only difference is that the cylindrical member 101 is provided.
The drug administration tool 1e of this embodiment is attached to the distal end of the cylindrical case 4, is slidable in the distal direction, and covers the distal opening 31a of the hollow tubular member 3 that protrudes from the cylindrical case 4. It is equipped with a cylindrical member 101.

The cylindrical member 101 is a short cylindrical body having an inner surface shape corresponding to the outer surface shape of the tip of the cylindrical case 4 . The cylindrical member 101 has a rib 102 on the inner surface of the rear end. The rib 102 is an annular rib. Note that the ribs 102 may be a plurality of ribs arranged circumferentially.

In the drug administration device 1e of the embodiment, the outer surface of the distal end of the cylindrical case 4 includes a first movement regulating rib 103 provided on the rear end side by a predetermined length from the distal end of the cylindrical case 4; A second movement regulating rib 105 is provided on the distal end side of the movement regulating rib 103 by a predetermined length. The first movement regulating rib 103 and the second movement regulating rib 105 are annular ribs. Note that the ribs may be a plurality of ribs arranged circumferentially. Further, the second movement regulating rib 105 is provided with an annular recess 106 into which the rib 102 of the cylindrical member 101 can engage (enter into).

In the drug administration device 1e of this embodiment, by sliding the cylindrical member 101 in the distal direction after using the drug administration device 1e, the distal opening 31a of the hollow tubular member 3 protruding from the cylindrical case 4 is covered. can be packaged. Furthermore, the rib 102 of the slid cylindrical member 101 enters and engages the annular recess 106 of the second movement regulating rib 105 of the cylindrical case 4, thereby moving the rib 102 of the cylindrical member 101 toward the rear end side. The movement of the cylindrical member 101 can be restricted, and the state in which the distal end opening 31a is covered by the cylindrical member 101 can be maintained.

Next, a drug administration device 1f according to another embodiment of the present invention shown in FIG. 27 will be described.
The basic structure of the drug administration device 1f of this embodiment is the same as the drug administration device 1 described above, and the difference is that the drug administration device 1f of this embodiment has the same structure as the drug administration device 1 described above, and the difference is that The only difference is that it includes a cylindrical member 110 and a biasing member 114 that biases the cylindrical member 110 in the distal direction.

The drug administration device 1f of this embodiment includes a cylindrical member 110 that is attached to the distal end of the cylindrical case 4 and that covers the distal end opening 31a of the hollow tubular member 3 that protrudes from the cylindrical case 4; The cylindrical member 110 is provided with a biasing means 114 that biases the cylindrical member 110 toward the distal end, and the cylindrical member 110 can be slid rearward by being pressed toward the distal end.

The drug administration tool 1f of this embodiment is attached to the distal end of the cylindrical case 4, is slidable in the distal direction, and covers the distal opening 31a of the hollow tubular member 3 protruding from the cylindrical case 4. It is provided with a cylindrical member 110.
The cylindrical member 110 is a short cylindrical body having an inner surface shape corresponding to the outer surface shape of the tip of the cylindrical case 4 . The cylindrical member 110 has a rib 102 on the inner surface of the rear end. The rib 102 is an annular rib. Note that the ribs 102 may be a plurality of ribs arranged circumferentially.

In the drug administration device 1f of the embodiment, on the outer surface of the distal end of the cylindrical case 4, a first movement regulating rib 103 provided on the rear end side by a predetermined distance from the distal end of the cylindrical case 4; A second movement regulating rib 116 is provided on the distal end side of the movement regulating rib 103 by a predetermined length. The first movement regulating rib 103 and the second movement regulating rib 116 are annular ribs. Note that the ribs may be a plurality of ribs arranged circumferentially.

The drug administration device 1f of this embodiment includes a biasing member 114 disposed on the outer periphery of the distal end of the cylindrical case 4. The biasing member 114 is disposed between the rear end of the cylindrical member 110 and the first movement regulating rib 103 of the cylindrical case 4, and biases the cylindrical member 110 in the distal direction and The distal end opening 31a of the hollow tubular member 3 that protrudes from the hollow tubular member 4 remains covered by the cylindrical member 110. In this embodiment, a coil spring is used as the biasing member 114, and the tip of the cylindrical case 4 passes through the biasing member 114.

Further, the inner rib 102 of the cylindrical member 110 contacts the second movement regulating rib 116 of the cylindrical case 4 and restricts further movement toward the tip and separation from the cylindrical case 4. .
In the drug administration device 1f of this embodiment, when the cylindrical member 110 is pushed backward (for example, when puncturing the tip opening 31a), it moves to the rear of the cylindrical case 4 and the hollow tubular member 3 The tip opening 31a is exposed, and when the rearward pressure on the cylindrical member 110 is released, the tip opening 31a of the hollow tubular member 3 protruding from the cylindrical case 4 is exposed again. It returns to the state covered by the shaped member 110.

Next, a drug administration device 1g according to another embodiment of the present invention shown in FIG. 28 will be described.
The drug administration device of all the embodiments described above may be provided with a package 15 that houses the drug administration device, like a drug administration device 1g of another embodiment of the present invention shown in FIG. Further, it is preferable that the drug administration device 1g is sealed after the drug administration device and a predetermined amount of hydrogen peroxide are put into the package 15. By adding hydrogen peroxide, bacteria on the surface of the internal drug administration device can be killed.

It is preferable that the package 15 is a functional package for adjusting hydrogen peroxide permeation amount. The functional package for adjusting hydrogen peroxide permeation amount refers to a package that allows and regulates the permeation of hydrogen peroxide by diffusion. Specifically, it refers to a material that allows hydrogen peroxide gas to permeate through diffusion, but suppresses the permeation in a short period of time. If hydrogen peroxide is allowed to permeate for a short period of time, it will not be possible to create an atmosphere with a sufficiently high concentration of hydrogen peroxide during the external sterilization process of medical products after packaging. If it does not transmit at all, hydrogen peroxide will remain inside the package. Therefore, the hydrogen peroxide permeation amount adjusting functional packaging does not include materials such as paper and porous films that have pores through which hydrogen peroxide can easily pass.

The hydrogen peroxide passing function of the package can be evaluated by measuring the transpiration of an aqueous solution containing hydrogen peroxide (hydrogen peroxide solution). When a hydrogen peroxide solution is enclosed in a packaging film and left in an environment above room temperature, water and hydrogen peroxide gradually evaporate within the packaging film and fill the packaging film. In parallel with the vaporization and filling of hydrogen peroxide, hydrogen peroxide permeates into the film of the package and then permeates therethrough, and the extent of this can be determined by the amount of reduction in hydrogen peroxide water droplets within the package. In other words, with porous films that allow hydrogen peroxide to easily pass through, the hydrogen peroxide droplets will decrease and disappear in a short time, but with packaging films that allow and restrict the permeation of hydrogen peroxide through diffusion, hydrogen peroxide droplets will decrease and disappear in a short time. It takes a certain amount of time for the water droplets to decrease and disappear.

The package 15 has a hydrogen peroxide permeation amount adjustment function, so that the amount of hydrogen peroxide per 1 cm ² of surface area of the package is 300 mg/L in a container having an internal capacity of 0.2 mL per 1 cm 2 of surface area of the package. After adding the adjusted hydrogen peroxide solution and sealing the container, the period during which the hydrogen peroxide droplets disappear under conditions of 55° C. and 25% RH is preferably in the range of 3 to 72 hours. In particular, it is preferable to have a hydrogen peroxide droplet disappearance period (transpiration) of 6 to 24 hours. Further, the package 15 may be of any type as long as it has the function of adjusting the amount of hydrogen peroxide permeation as a whole.

Further, in all the embodiments described above, the pressing operation portion 23a of the gasket pressing member 23 may be able to enter into the cylindrical case 4. By doing this, when the gasket pressing member 23 is pushed all the way, the pressing operation part 23a of the gasket pressing member is housed in the cylindrical case 4, thereby preventing the gasket pressing member 23 from being pulled out and completing the administration. It becomes a landmark.

1 Drug administration tool 2 Prefilled syringe 3 Hollow tubular member 4 Cylindrical case 5 Stopper 11 Biasing member

Claims (11)

a hollow tubular member having a distal end opening having a blade surface and a rear end open needle portion having a blade surface; a prefilled syringe; A drug administration device comprising a cylindrical case for storing the drug,
The hollow tubular member includes a tubular body having the tip opening and the rear opening needle, and a hub attached to an intermediate portion of the tubular body,
The cylindrical case includes a hollow tubular member mounting portion that protrudes inward from the inner surface and has the hub attached thereto, and a side opening provided at the rear end, and further includes a side opening provided at the rear end of the hollow tubular member. The prefilled syringe is housed so that the hollow tubular member mounting part protrudes and is immovable, and the prefilled syringe is housed in the cylindrical case so as to be movable in the direction of the rear end opening needle part of the hollow tubular member. ,
The prefilled syringe includes an outer cylinder having an outer surface protrusion at its rear end, a sealing member that seals the distal end of the outer cylinder and allows the rear end opening needle to penetrate, and an inner cylinder. a gasket member capable of sliding in a liquid-tight state, and a gasket pressing member that can be attached to the gasket member and whose rear part protrudes from the cylindrical case when attached ,
The drug administration device includes a biasing member that contacts the outer cylinder and biases the prefilled syringe toward the rear end open needle portion;
a stopper that is removably inserted into the side opening of the cylindrical case, contacts the outer surface protrusion of the outer cylinder, and restricts movement of the prefilled syringe in the direction of the hollow tubular member;
The stopper includes a base, two extending portions extending forward from the base and facing each other, and a notch formed between the two extending portions and the base for penetrating the main body of the outer cylinder. The cylindrical case includes an engaging portion with the two extension portions, and the stopper is configured to engage the side opening of the cylindrical case when the stopper is attached to the cylindrical case. and the distal end portions of the two extending portions are engaged with the engaging portion of the cylindrical case,
In the drug administration device, after the stopper is detached, the prefilled syringe moves toward the hollow tubular member due to the pressure of the biasing member, and the sealing member of the prefilled syringe is moved by the rear end open needle portion. A drug administration device characterized by being in a penetrating state. The hollow tubular member includes a tubular body having the distal end opening and the rear opening needle, a hub attached to an intermediate portion of the tubular body, one end attached to the hub, and a rear end closed. , and an elastic sleeve that envelops the rear end open needle part, and the elastic sleeve can be pierced by the rear end open needle part by being pressed in the direction of the hub. Drug administration equipment. The drug administration device according to claim 1 or 2, wherein the drug administration device includes a cap that covers the tip opening of the hollow tubular member. The cylindrical case has two side openings facing each other, one of the side openings of the cylindrical case engages with the base of the stopper, and the other side opening of the cylindrical case engages with the base of the stopper. The drug administration device according to any one of claims 1 to 3 , wherein the side opening is the engaging portion that engages with the distal end portions of the two extending portions . After the stopper is removed and the rear end open needle portion of the hollow tubular member passes through the sealing member of the prefilled syringe, the cylindrical case closes the outer surface protrusion of the prefilled syringe. 5. The drug administration device according to claim 1, further comprising an abutment portion that abuts against the distal end surface of the drug administration device to restrict movement. The cylindrical case includes a guide portion that protrudes inward from an inner surface of the cylindrical case at a position corresponding to the cylindrical body of the stored prefilled syringe and guides sliding of the prefilled syringe. Item 5. The drug administration device according to any one of Items 1 to 5 . 7. The drug administration device according to claim 1, wherein the biasing member is a coil spring in a compressed state. The drug administration device according to any one of claims 1 to 7, wherein the gasket pressing member is attached to the gasket member . The drug administration device is removably attached to the side of the gasket pressing member, and the distal end of the gasket pressing member can come into contact with the rear end of the cylindrical case when the gasket pressing member moves forward. The drug administration device according to any one of claims 1 to 8, further comprising a movement regulating member for regulating movement. The drug administration device is attached to the distal end of the cylindrical case, is slidable in the distal direction, and has a cylindrical shape for enclosing the distal opening of the hollow tubular member that protrudes from the cylindrical case. The drug administration device according to any one of claims 1 to 9 , comprising a member. The drug administration device includes a cylindrical member attached to the distal end of the cylindrical case and for enclosing the distal opening of the hollow tubular member protruding from the cylindrical case; 10. The drug administration device according to claim 1, further comprising a biasing means for biasing the cylindrical member in a direction, and the cylindrical member is slidable rearward when pressed.

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