JP7459489B2 - Oral composition - Google Patents

Description

The present invention relates to an oral composition that is excellent in the effect of imparting a feeling of moisture to the oral cavity.

Dryness in the oral cavity can cause oral problems such as bad breath, caries, and periodontal disease, which are accompanied by oral malfunction. Moisturizing the inside of the oral cavity is important for keeping the inside of the mouth refreshed and preventing oral diseases, so it is very important to give the inside of the mouth a feeling of moisture.
Examples of methods for moisturizing the oral cavity include moisturizing the oral cavity using artificial saliva, oral moisturizing/wetting agents, and the like. In the conventional technology, as shown in Patent Document 1 (International Publication No. 2000/056344), hyaluronic acid is applied as an additive to artificial saliva to improve symptoms caused by dry mouth. Although moisturizing effects have been used to moisturize the oral cavity, it has not been possible to achieve a sufficient feeling of moisture.
On the other hand, in Patent Documents 2 to 4 (JP 2006-117563, JP 2009-96748, JP 2017-1957), a salivary secretion stimulant such as polyglutamic acid is added to an oral composition. However, although techniques for producing an oral cavity moisturizing effect have been proposed, there is still room for improvement in the feeling of moisturizing, especially its sustainability.
Therefore, it has been desired to develop a new technology that provides a feeling of high moisture in the oral cavity.

International Publication No. 2000/056344 JP 2006-117563 A JP2009-96748A JP 2017-1957 Publication JP2016-222582A

The present invention was made in view of the above circumstances, and an object of the present invention is to provide an oral composition that is excellent in the effect of imparting a feeling of moisture to the oral cavity and has the effect of imparting gloss to tooth surfaces.

As a result of intensive studies to achieve the above object, the present inventors found that when a specific flavoring material is combined with a cellulose-based polymer substance and/or xanthan gum and incorporated into an oral composition, the oral mucosa is moisturized. It has been found that it is possible to impart a feeling of high moisture that lasts significantly over time, and also to increase and improve the gloss of the tooth surface. That is, according to the present invention, (A) one or two selected from cis-3-hexenyl acetate and phenylethyl acetate, and (B) one or more selected from cellulose polymer substances and xanthan gum. The oral composition containing the above has an excellent effect of imparting a feeling of moisture to the oral cavity, provides a feeling of high moisture that lasts over time, and has an effect of imparting gloss to the tooth surface, giving a high degree of gloss to the tooth surface. The present invention has been completed based on the discovery that the present invention provides the following properties.

In the present invention, the combination of components (A) and (B) provides the above-mentioned special effects, which could not be obtained by using another fragrance component in place of component (A).
As shown in the examples below, the oral composition containing the components (A) and (B) has an excellent moisturizing effect, excellent moisturizing effect and its duration, and excellent glossing effect on the tooth surface. On the other hand, as shown in the comparative examples below, the absence of the components (A) or (B) results in poorer effects of the present invention, and when the component (B) is used alone, the moisturizing effect and its duration are poor, and the glossing effect on the tooth surface is poor, even when a general oral flavoring component other than the component (A) is added (Comparative Example 2), and when the component (A) is used alone, the moisturizing effect and its duration are poor, and the glossing effect on the tooth surface is poor (Comparative Example 1). In this case, even when sodium polyacrylate (Mw: 300,000), which is also a general binder, is further added, the moisturizing effect is poor (Comparative Example 3).
Cis-3-hexenyl acetate and phenylethyl acetate are known as flavoring ingredients used in oral compositions, and in Patent Document 5 (JP Patent Publication 2016-222582 A), they are incorporated into an oral composition containing a water-soluble active ingredient to impart a refreshing feeling of use. In contrast, the present invention is directed to improving the effect of imparting a moist feeling and gloss to the tooth surface by components (A) and (B), and no action or effect specific to such a combined system can be imagined from Patent Document 5.

Accordingly, the present invention provides the following oral compositions.
[1]
(A) one or two selected from cis-3-hexenyl acetate and phenylethyl acetate,
(B) an oral composition comprising one or more substances selected from a cellulose-based polymeric substance and xanthan gum.
[2]
The oral composition according to claim 1, wherein the component (A) is cis-3-hexenyl acetate (A1) and phenylethyl acetate (A2).
[3]
The oral composition according to [2], wherein (A2)/(A1), which represents the ratio of the amount of the component (A1) to the amount of the component (A2), is 0.025 to 40 as a mass ratio.
[4]
The oral composition according to any one of [1] to [3], wherein the cellulose-based polymeric substance is selected from sodium carboxymethylcellulose (B1), hydroxyethylcellulose (B2) and cationic cellulose (B3).
[5]
The oral composition according to any one of items [1] to [4], wherein the content of component (A) is 0.0005 to 0.1 mass % and the content of component (B) is 0.01 to 2 mass %.
[6]
The oral composition according to any one of [1] to [5], wherein (B)/(A), which indicates the ratio of the amount of the (A) component to the amount of the (B) component, is 10 to 500 as a mass ratio.
[7]
The oral composition according to any one of [1] to [6], further comprising (C) 0.01 to 2 mass % of a polyacrylate having a weight average molecular weight of 1,000 or more and 20,000 or less.
[8]
The oral composition according to any one of [1] to [7], wherein the ratio of the amounts of the components (A) and (B) to the amount of the component (C), {(A) + (B)} / (C), is 1 to 100 in terms of mass ratio.
[9]
The oral composition according to any one of [1] to [8], which is a dentifrice composition.

According to the present invention, the oral cavity has an excellent effect of imparting a feeling of moisture to the oral cavity, provides a feeling of high moisture that lasts over time, and has an effect of imparting gloss to the tooth surface, giving a high degree of gloss to the tooth surface. A composition can be provided. This oral composition moisturizes the oral cavity and gives an excellent feeling of moisture, and increases the gloss of the tooth surface, so in addition to improving the aesthetics of teeth, it also keeps the oral cavity refreshed and eliminates bad breath. It is effective for preventing or suppressing oral diseases such as dental caries and periodontal diseases, especially xerostomia.

The present invention will be described in further detail below. The oral composition of the present invention contains (A) one or more selected from cis-3-hexenyl acetate and phenylethyl acetate, and (B) one or more selected from cellulose-based polymeric substances and xanthan gum.

The component (A) is cis-3-hexenyl acetate (A1) or phenylethyl acetate (A2). Although one of these may be used alone, it is preferable to use a mixture of cis-3-hexenyl acetate (A1) and phenylethyl acetate (A2) in combination from the viewpoints of providing a moisturizing sensation and gloss to the tooth surface.
When components (A1) and (A2) are used in combination as component (A), the ratio of the amounts of the two components, (A2)/(A1), is preferably a mass ratio of 0.025 to 40, more preferably 0.1 to 10, and even more preferably 0.2 to 5. Within the above range, a sufficient moist feeling can be imparted and its duration can be maintained, and a sufficient effect of imparting luster to the tooth surface can be imparted.
The cis-3-hexenyl acetate of the component (A1) may be a commercially available product, for example, a product manufactured by Nippon Zeon Co., Ltd. The phenylethyl acetate of the component (A2) may be a commercially available product, for example, a product manufactured by Toyotama Fragrance Co., Ltd.

The blending amount of component (A) is preferably 0.0005 to 0.1% (mass%, the same applies hereinafter) based on the entire composition, more preferably 0.002 to 0.04%, and still more preferably 0.004 to 0.04%. It is 0.02%. When the blending amount is 0.0005% or more, a sufficient feeling of moisture and its sustainability can be imparted, and a sufficient gloss-imparting effect on the tooth surface can be imparted.
Furthermore, when using components (A1) and (A2) together as component (A), both must be used within the range of the amount of component (A) above and in an amount that satisfies the mass ratio of (A2)/(A1). It is preferable to mix the ingredients. In this case, the preferred blending amount of component (A1) is 0.0005 to 0.05% of the entire composition, more preferably 0.001 to 0.02%, still more preferably 0.002 to 0.01%. %. The preferred blending amount of component (A2) is 0.0005 to 0.05% of the entire composition, more preferably 0.001 to 0.02%, and still more preferably 0.002 to 0.01%. .

The component (B) is a cellulose-based polymeric substance, xanthan gum, and may be used alone or in combination of two or more types.
The cellulose-based polymer substance may be any cellulose or derivative thereof known for use in oral compositions, such as sodium carboxymethylcellulose, methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxymethylethylcellulose, cationic cellulose, etc.
Of the cellulose-based polymeric substances, sodium carboxymethylcellulose (B1), hydroxyethylcellulose (B2), and cationic cellulose (B3) are preferred from the viewpoint of providing a moisturizing feeling.

As the cellulose-based polymer material, sodium carboxymethyl cellulose as component (B1) can be used having a degree of etherification of preferably 0.1 to 2, particularly 0.2 to 2.
In addition, carboxymethyl cellulose sodium has a viscosity of less than 75 mPa·s, particularly 10 to 74 mPa·s, particularly 20 to 70 mPa·s, in a 1% aqueous solution at 25°C, from the viewpoint of providing a feeling of moisture and giving gloss to tooth surfaces. The viscosity of a 1% aqueous solution at 25° C. is preferably 75 mPa·s or more, particularly 75 to 1,000 mPa·s, especially 80 to 500 mPa·s.
The above viscosity is a value obtained by measuring a 1% aqueous solution of sodium carboxymethyl cellulose at 25° C. using a BM type viscometer (rotor No. 2 or 3, rotation speed 60 rpm, measurement time 3 minutes) (the same applies hereinafter).
Such sodium carboxymethyl cellulose can be commercially available, such as Sunrose SLD-F1, SLD-FM manufactured by Nippon Paper Industries Co., Ltd., Daicel 1130, Daicel 1330, Daicel 1310, Daicel 1140 manufactured by Daicel Corporation. , Daicel 1250, Daicel 1260, etc.

The hydroxyethylcellulose component (B2) preferably has a viscosity of 1% aqueous solution at 25°C of 1,000 mPa·s or more and 10,000 mPa·s or less, from the viewpoint of imparting a feeling of moisture and gloss to the tooth surface. Preferably it is 1,000 to 9,000 mPa·s.
The above viscosity is a value obtained by measuring a 1% aqueous solution of hydroxyethyl cellulose at 25° C. using a BH Brookfield viscometer (rotor No. 2, 20 rotations, measurement time 1 minute) (the same applies hereinafter).

The cationic cellulose of component (B3) may be, for example, a cellulose derivative to which a cationic group such as dimethyldiallylammonium chloride or 2-hydroxy-3-(trimethylammonio)propyl group has been added. For example, hydroxyethylcellulose dimethyldiallylammonium salts such as hydroxyethylcellulose dimethyldiallylammonium chloride, O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethylcellulose chloride, etc. may be used, with hydroxyethylcellulose dimethyldiallylammonium salt being particularly preferred from the standpoint of providing a moisturizing sensation.

From the viewpoint of providing a moist feeling, the viscosity of a 2% aqueous solution of the cationic cellulose at 21° C. is preferably 30 to 3,000 mPa·s, and more preferably 35 to 350 mPa·s.
The above viscosity was measured by using a BH type Brookfield viscometer (rotor No. 2, 20 revolutions, measurement time 1 minute) at 21° C. for a 2% aqueous solution of cationized cellulose (hereinafter the same).
The nitrogen content of the cationic cellulose is preferably 0.1 to 3%, and more preferably 0.5 to 2.5%.
The weight-average molecular weight of the cationic cellulose is not particularly limited, but from the viewpoint of providing a moisturizing sensation, it is preferable that the weight-average molecular weight (hereinafter the same) measured by gel permeation chromatography (GPC) using polyethylene glycol as the standard substance is 250,000 to 1,500,000.
As such cationic cellulose, commercially available products can be used. Specific examples of hydroxyethyl cellulose dimethyl diallyl ammonium salt include Cellcoat L-200 (viscosity of 2% aqueous solution at 21° C.: 35 to 350 mPa·s, weight average molecular weight: 250,000 to 350,000) manufactured by Nippon NSC Co., Ltd.

The xanthan gum may be any of those normally used in dentifrice compositions, especially from the point of view of imparting a feeling of moisture, but when xanthan gum is dissolved in a 1% potassium chloride solution to a concentration of 1%. The viscosity at 25° C. of 600 to 2,500 mPa·s, particularly 1,000 to 2,000 mPa·s is preferable. In addition, the said viscosity is the value measured using the BM type viscometer (rotor No. 3, rotation speed 60 rpm, measurement time 3 minutes) at 25 degreeC.
As component (B), carboxymethyl cellulose sodium (B1), hydroxyethyl cellulose (B2), cationized cellulose (B3), and xanthan gum (B4) can be preferably used, especially from the viewpoint of imparting a feeling of moisture.

Component (B) may be a combination of a cellulose-based polymeric substance and xanthan gum. In particular, when the two are used in combination, it is more preferable in terms of the effectiveness of the product to use xanthan gum with reduced cellulase activity. Xanthan gum with reduced cellulase activity is produced so as to prevent contamination with cellulase during production. An example of a xanthan gum that satisfies the above viscosity and has reduced cellulase activity is Keldent manufactured by CP Kelco.

The amount of component (B) is preferably 0.01 to 2% of the total composition. If the amount is 0.01% or more, a sufficient moist feeling can be imparted and the feeling can be sustained, and the effect of imparting luster to the tooth surface can be sufficiently imparted. If the amount is 2% or less, it is preferable to ensure the taste and flavor of the preparation.
Furthermore, when sodium carboxymethylcellulose (B1) is used as component (B), the amount of component (B1) is preferably 0.1 to 2%, particularly 0.2 to 2%, and especially 0.3 to 2% of the total composition.
When hydroxyethyl cellulose (B2) is used as component (B), the amount of component (B2) is preferably 0.1 to 2%, particularly 0.2 to 2%, and especially 0.3 to 2%, of the entire composition.
When cationic cellulose (B3) is used as component (B), the amount of component (B3) is preferably 0.01 to 2%, particularly 0.02 to 2%, and especially 0.03 to 1% of the entire composition.
When xanthan gum (B4) is used as component (B), the amount of component (B4) blended is preferably 0.1 to 2%, particularly 0.2 to 2%, and especially 0.3 to 2.0% of the total composition.

In the present invention, (B)/(A), which indicates the quantitative ratio of component (A) and component (B) (total ratio of each), is preferably 10 to 500 as a mass ratio, more preferably 40 to 400, More preferably it is 100-350. If it is within the above range, the effect of imparting a feeling of moisture will be better, the feeling of moisture and its sustainability, especially the sustainability of the feeling of moisture will be further enhanced, and the effect of imparting gloss to the tooth surface will be further improved.

In the present invention, it is preferable to further incorporate (C) a polyacrylate having a weight-average molecular weight (Mw) of 1,000 to 20,000. By incorporating the (C) component, the moisturizing effect and gloss-imparting effect to the tooth surface of the (A) and (B) components are further improved, the moisturizing effect is further sustained, and the gloss of the tooth surface can be further increased. In this case, it is preferable to incorporate the (C) component, particularly in a (B)/(A) mass ratio within the above-mentioned specific range, in order to increase the gloss of the tooth surface.

The weight-average molecular weight of the polyacrylate is 1,000 or more, preferably 6,000 or more, and 20,000 or less, preferably 10,000 or less. When the weight-average molecular weight is 1,000 or more, the effect of providing a moist feeling is sufficiently improved, and in particular, the duration of the moist feeling can be sufficiently increased, and the effect of providing gloss to the tooth surface is sufficiently improved, and the glossiness can be sufficiently increased. When the weight-average molecular weight is 20,000 or less, the above effect can be sufficiently maintained. When it exceeds 20,000, the effect of providing gloss to the tooth surface may tend to decrease.
The weight average molecular weight was measured by gel permeation chromatography (GPC) according to the method and conditions described in Japanese Patent No. 5740859 (hereinafter the same).
Measurement method of weight average molecular weight:
The weight average molecular weight is a value measured using gel permeation chromatography/multi-angle laser light scattering detector (GPC-MALLS) under the following conditions.
Mobile phase: 0.3M _NaClO4
NaN3 aqueous solution Column: TSKgelα-M 2 pieces Precolumn: TSKguardcolumn α
Standard material: polyethylene glycol

The polyacrylate as component (C) is preferably a linear polyacrylate from the viewpoint of imparting a feeling of moisture and gloss to the tooth surface. As the salt, monovalent salts are preferred, alkali metal salts or ammonium salts are more preferred, alkali metal salts such as sodium salts and potassium salts are still more preferred, and sodium salts are particularly preferred.
As the component (C), commercially available polyacrylates sold by Polyscience Co., Ltd. and Toagosei Co., Ltd. may be used. Specifically, commercially available products include sodium polyacrylate (Mw: 1,000); linear, manufactured by Polyscience; sodium polyacrylate (Mw: 6,000); linear; manufactured by Toagosei Co., Ltd. manufactured by Polyscience, AC-10NP, AC-10NPD, Aron T-50, sodium polyacrylate (Mw: 9,000); linear, manufactured by Polyscience, sodium polyacrylate (Mw: 20,000); linear Aron A-20UN manufactured by Toagosei Co., Ltd. can be used.
In addition, the polyacrylate of component (C) has a weight average molecular weight lower than that of the crosslinked polyacrylate as a binder normally used in dentifrices, and is a polyacrylate salt known as a binder. It is different from If a polyacrylate other than component (C) is used in place of component (C), or if polyacrylic acid that is not in the form of a salt is used, the effect of imparting a feeling of moisture will be poor, especially the The durability becomes poor and the object of the present invention is not achieved.

The amount of component (C) in the composition is preferably 0.01 to 2% of the total composition, more preferably 0.01 to 1%, and even more preferably 0.03 to 0.5%, in order to provide a moisturizing sensation and gloss to the tooth surface.

When component (C) is added, the ratio of components (A) and (B) to component (C), {(A)+(B)}/(C), is preferably 1 to 100 by mass, more preferably 2 to 80, and even more preferably 4 to 70, in terms of improving the effect of providing a moisturizing sensation and the effect of providing gloss to the tooth surface.

The oral composition of the present invention is suitable as a dentifrice composition, and can be prepared into toothpaste, liquid toothpaste, moisturized toothpaste, etc., and toothpaste is particularly preferred. In addition to the above-mentioned components, other known components may be blended as needed within a range that does not impede the effects of the present invention. For example, in a dentifrice composition such as a toothpaste, an abrasive, a thickening agent, a binder, a surfactant, and if necessary, a sweetener, a coloring agent, a preservative, a fragrance, an active ingredient, etc. can be added. Incidentally, the blending amount may be a normal amount within a range that does not impede the effects of the present invention.

Examples of abrasives include silica-based abrasives such as precipitated silica, aluminosilicate, and zirconosilicate; calcium phosphate-based compounds such as dibasic calcium phosphate dihydrate or anhydrate, monobasic calcium phosphate, and tribasic calcium phosphate; calcium carbonate, calcium hydroxide, aluminum hydroxide, and synthetic resin-based abrasives. The amount of abrasive used is usually 2 to 50% of the total composition, and particularly 10 to 30%.

Examples of thickening agents include sugar alcohols such as sorbitol, xylitol, and erythritol, and polyhydric alcohols such as glycerin, propylene glycol, and polyethylene glycols with an average molecular weight of 160 to 400 (average molecular weight as stated in the Quasi-Drug Raw Materials Standards 2006). The amount of these agents blended is usually 5 to 50% of the total composition, and particularly 20 to 45%.

Examples of the binder include inorganic binders such as gelling silica, gelling aluminum silica, vegum, bentonite, and laponite. Note that organic binders other than component (B), such as gums such as karaya gum, carrageenan, alginates, polyvinyl alcohol, carboxyvinyl polymers, polyvinylpyrrolidone, etc., may be added as long as they do not impede the effects of the present invention. However, it is not necessary to include it. The blending amount of these optional binders is preferably 0 to 10%, particularly 0.1 to 5%, based on the total composition.

The surfactant that can be blended includes an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant.
Examples of the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, acyl sarcosinates, and acyl glutamates.
Examples of the nonionic surfactant include sugar fatty acid esters such as sucrose fatty acid esters, sugar alcohol fatty acid esters such as maltitol fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, and polyoxyethylene higher alcohol ethers.
Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts, and examples of the amphoteric surfactant include alkyl betaine, alkyl dimethyl amino acetate betaine, and alkyl imidazolinium betaine.
The amount of the surfactant to be blended is preferably 0.001 to 10%, particularly preferably 0.01 to 5%, of the total composition.

Examples of sweeteners include sodium saccharin and stevioside.
Examples of the coloring agent include Blue No. 1, Yellow No. 4, and titanium dioxide.
Examples of preservatives include paraoxybenzoic acid esters such as methylparaben and ethylparaben, benzoic acid or salts thereof, and the like.

The flavoring may be anything other than component (A). For example, natural flavorings such as peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, mint oil, cardamom oil, coriander oil, mandarin oil, lime oil, lavender oil, rosemary oil, laurel oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, grapefruit oil, sweetie oil, yuzu oil, absolute peppermint, and orange flower, as well as flavorings obtained by processing (front distillation, back distillation, fractional distillation, liquid-liquid extraction, essence preparation, powdered flavor preparation, etc.) of these natural flavorings, as well as menthol, carvone, anethole, cineole, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, and the like. [0043] The flavor materials that can be used in combination with the flavor materials are known to be used in compositions for the oral cavity, such as single flavors such as ethanol, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramenthan-3-carboxamide, pinene, octylaldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methylphenyl glycidate, vanillin, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, and ethyl thioacetate, as well as blended flavors such as butter flavor and milk flavor, but are not limited to the flavors described in the examples.
The blending amount of the above-mentioned flavoring materials is not particularly limited, but it is preferable to use the above-mentioned flavoring materials in an amount of 0.000001 to 1% in the composition, and it is preferable to use the above-mentioned flavoring materials in an amount of 0.1 to 2% in the composition.

Active ingredients include disinfectants such as isopropyl methylphenol and cetylpyridinium chloride, anti-inflammatory agents such as tranexamic acid, epsilon aminocaproic acid, and allantoin, enzymes such as dextranase, amylase, protease, and lysozyme, sodium fluoride, and monofluoroline. Examples include fluorides such as sodium acid, water-soluble copper compounds, sodium chloride, potassium nitrate, aluminum lactate, vitamins, plant extracts such as thyme and scutellariae, anti-tartar agents, and anti-plaque agents. The above-mentioned active ingredients can be blended in an effective amount within a range that does not impede the effects of the present invention.

The present invention will be specifically explained below with examples and comparative examples, but the present invention is not limited to the following examples. In the following examples, % indicates mass % unless otherwise specified.

[Examples and Comparative Examples]
Dentifrice compositions (toothpastes) having the compositions shown in Tables 1 to 6 were prepared by the following method, filled into tube containers (aluminum laminated tubes), and evaluated by the methods described below. The results are shown in Tables 1 to 6.
Furthermore, the dentifrice compositions of the examples were excellent in the effect of moisturizing the oral cavity after use.

<Preparation Method>
(1) Component (A), other water-soluble components other than component (B) (when component (C) is further added, other than components (B) and (C)), titanium oxide, and a viscosity modifier were mixed and dissolved in purified water at room temperature (mixture X).
(2) Component (B) and further component (C) were dispersed in propylene glycol at room temperature (mixture Y), and mixture Y was added to and mixed with mixture X while stirring to prepare mixture Z.
(3) The flavoring and the abrasive were mixed into the mixture Z at room temperature using a kneader, and the mixture was degassed under reduced pressure (5.3 kPa) to obtain a dentifrice composition.
The dentifrice compositions of the comparative examples were prepared according to the above method.

<Evaluation method>
(1) Moisture feeling and evaluation method for its sustainability The feeling of moisture in the oral cavity when 1 g of the dentifrice composition was placed on a toothbrush and brushed for 3 minutes to clean the oral cavity, and the oral cavity after 5 minutes had elapsed after brushing. The feeling of inner moisture (persistence of feeling of moisture) was compared with the control product (Comparative Example 1) and evaluated using the following four-level scoring criteria. The average score of the 10 people was calculated and evaluated according to each evaluation standard, and the results were shown in the table as ◎◎, ◎, ○, △, and ×. Those rated ◎◎, ◎, or ◎ are judged to have a moisturizing feeling and the durability of the moisturizing feeling are increasing, and are excellent in the effect of imparting a moisturizing feeling.
The dentifrice composition of Comparative Example 1 gave a weak feeling of moisture in the oral cavity when the inside of the oral cavity was cleaned by brushing, and also had a weak feeling of moisture in the oral cavity after 5 minutes had elapsed.

Sensation of Moisture Rating Criteria 4: Compared to the control product, there was a significantly greater sensation of moisture in the oral cavity.
3: There was a slight feeling of moisture in the mouth compared to the control product.
2: No difference in the feeling of moisture in the oral cavity was observed compared to the control product.
1: Equivalent to the control product, with a weak sense of moistness in the oral cavity.
Evaluation criteria: ◎◎: average score 3.7 points or more and 4.0 points or less ◎: average score 3.5 points or more and less than 3.7 points ○: average score 3.0 points or more and less than 3.5 points △: average score 2.0 points or more and less than 3.0 points ×: average score 1.0 points or more and less than 2.0 points

Duration of moist sensation Rating criteria: 4: Compared to the control product, there was a significantly greater feeling of moistness in the oral cavity.
3: There was a slight feeling of moisture in the mouth compared to the control product.
2: No difference in the feeling of moisture in the oral cavity was observed compared to the control product.
1: Equivalent to the control product, with a weak sense of moistness in the oral cavity.
Evaluation criteria: ◎◎: average score 3.7 points or more and 4.0 points or less ◎: average score 3.5 points or more and less than 3.7 points ○: average score 3.0 points or more and less than 3.5 points △: average score 2.0 points or more and less than 3.0 points ×: average score 1.0 points or more and less than 2.0 points

(2) Method for evaluating the gloss imparting effect on tooth surfaces As a model tooth surface, hydroxyapatite (HA) (hydroxyapatite pellets, manufactured by HOYA Co., Ltd., diameter 7 mm) was added to lactic acid buffer (pH 4.5) at 90°C. After dipping for a minute, the initial glossiness (Gss value) of the HA was measured using Gloss Meter VG-2000 manufactured by Nippon Denshoku Kogyo Co., Ltd. Further, HA was added to a sample solution (10 g of dentifrice composition + 30 g of 60% glycerin), brushed 3,000 times in the solution, washed with distilled water, and then dried. Thereafter, the glossiness of HA (glossiness after treatment with the dentifrice composition, Gsa value) was measured, and the glossiness value (AGs value) was calculated using the following formula. The calculated values were evaluated according to the following evaluation criteria and indicated in the table as ◎◎, ◎, ○, △, and ×. Those rated ◎◎, ◎, or ○ were judged to have excellent gloss imparting effects on tooth surfaces.
Glossiness value (AGs) =
Glossiness (Gsa) after treatment with dentifrice composition - initial glossiness (Gss)
Evaluation criteria for gloss imparting effect ◎◎: Gloss imparting value is 15 or more ◎: Gloss imparting value is 12 or more and less than 15 ○: Gloss imparting value is 10 or more and less than 12 △: Gloss imparting value is 5 or more and less than 10 ×: Gloss imparting value is less than 5

Details of the components (B) and (C) used are shown below.
The viscosity of component (B), which will be described later, was measured under the same conditions using a BM type viscometer or a BH type Brookfield viscometer as described above. Regarding component (C), the numerical value after Mw in the table is the weight average molecular weight, and the weight average molecular weight was measured by the gel permeation chromatography (GPC) method using polyethylene glycol as a standard substance in the same manner as above.
(B) Component carboxymethyl cellulose sodium (B1-1)
Etherification degree: 0.2-2,
Viscosity of 1% aqueous solution at 25°C: 10 to 74 mPa・s
Carboxymethyl cellulose sodium (B1-2)
Etherification degree: 0.2-2,
Viscosity of 1% aqueous solution at 25°C: 75 to 1,000 mPa・s
Hydroxyethyl cellulose (B2)
Viscosity of 1% aqueous solution at 25°C: 1,000 to 9,000 mPa・s
Hydroxyethyl cellulose dimethyl diallylammonium chloride (B3)
Viscosity of 2% aqueous solution at 21°C: 35 to 350 mPa・s,
Weight average molecular weight: 250,000 to 350,000,
Manufactured by Japan NSC Co., Ltd., product name: Cellcoat L-200
Xanthan gum (B4)
Manufactured by CP Kelco, trade name: Keldent (C) component Sodium polyacrylate (C1) (Mw: 1,000)
Linear, manufactured by Polyscience, sodium polyacrylate (C2) (Mw: 6,000)
Linear, manufactured by Toagosei Co., Ltd., product name: AC-10NP
Sodium polyacrylate (C3) (Mw: 9,000)
Linear, manufactured by Polyscience, sodium polyacrylate (C4) (Mw: 20,000)
Linear, manufactured by Toagosei Co., Ltd., product name: Aron A-20UN

＊；香料の組成は下記の通りである（以下同様）。
アネトール １０
メントール ５５
エタノール ３５
合計 １００％

*: The composition of the fragrance is as follows (same below).
Anethole 10
Menthol 55
Ethanol 35
Total 100%

Claims (8)

(A) cis-3-hexenyl acetate and phenylethyl acetate ;
(B) one or more selected from cellulose-based polymer substances and xanthan gum;
(C) contains a polyacrylate having a weight average molecular weight of 1,000 or more and 20,000 or less, and indicates the weight ratio of components (A) and (B) to component (C) {(A)+(B) )}/(C) is 1 to 100 as a mass ratio. 2. The oral composition according to claim 1 , wherein the ratio of the components (A1) and (A2), (A2)/(A1), is 0.025 to 40 by mass. 3. The oral composition according to claim 1, wherein the cellulose-based polymeric substance is selected from the group consisting of sodium carboxymethylcellulose (B1), hydroxyethylcellulose (B2) and cationic cellulose (B3). 4. The oral composition according to claim 1 , wherein the content of component (A) is 0.0005 to 0.1% by mass, and the content of component (B) is 0.01 to 2% by mass. 5. The oral composition according to claim 1 , wherein the ratio of the component (A) to the component (B), (B)/(A), is 10 to 500 by mass. The oral composition according to any one of claims 1 to 5 , wherein the content of component (C) is 0.01 to 2 mass%. Any one of claims 1 to 6 , wherein {(A)+(B)}/(C), which represents the quantitative ratio of components (A) and (B) to component (C), is 2 to 80 as a mass ratio. The oral composition according to item 1. The oral composition according to any one of claims 1 to 7 , which is a dentifrice composition.