JP7587929B2 - Cheilitis relief agent - Google Patents

Description

The present invention relates to an agent for improving cheilitis.

The lips are a special part of the body that, anatomically, has the characteristics of a mucous membrane, is rich in capillaries, and has a high blood flow (Non-Patent Document 1). The lips have a mucous epithelial layer, but do not have a stratum corneum, making it difficult to maintain their barrier function (Non-Patent Document 2). Despite this special structure, the lips are in contact with the outside world and are constantly exposed to physical and chemical stimuli, making them a part of the body that is prone to problems. The turnover rate of the lips is very short, averaging 3.5 days, but repeated stimuli are applied even during the repair stage, causing problems to occur one after another, leading to a state where recovery does not occur.

On the other hand, Toki-inshi is a traditional Chinese medicine made up of 10 kinds of herbal medicines, and is based on "Shimotsuto" (Non-Patent Document 3), which has the effect of promoting hematopoiesis in the bone marrow. For this reason, Toki-inshi is used to replenish "blood" in the "blood deficiency" state (Patent Document 4), and is applied to "the following symptoms of people with poor circulation: chronic eczema (with little secretion), itching" (Non-Patent Document 5).

"Maruho Dermatology Seminar, 68th Japanese Dermatological Association Chubu Branch Academic Conference 3, Educational Lecture 8, How to Diagnose Skin Diseases on the Lips and Perioral Areas", 2018, [Retrieved May 21, 2020], Internet <URL: http://medical.radionikkei.jp/maruho_hifuka/maruho_hifuka_pdf/maruho_hifuka-180628.pdf> Journal of the Japanese Cosmetics Society Vol. 42, No. 1, pp. 1-8 (2018) Journal of Japanese and Chinese Medicine 12, 229-234, 1995 Chinese Herbal Medicine Dictionary, Revised Edition, Shufu to Seikatsusha, April 8, 2016 Pharmaceutical interview form "Kampo preparation Tsumura Tokiinko extract granules (medical use)" March 2013 (Revised 3rd edition)

Angelica extract is used to treat conditions such as chronic eczema caused by "blood deficiency," but it is not known to be effective against cheilitis. First of all, the lips are an extension of the mucous membrane and have a structure very different from that of the skin, and the lips are rich in capillaries and have a high blood flow, so Angelica extract cannot be expected to have any effect on improving cheilitis.

The present invention aims to provide a drug that can improve cheilitis.

After extensive research, the inventors discovered that Angelica sinensis has the effect of improving cheilitis. Based on this knowledge, the present invention was completed through further research.

That is, the present invention provides the following aspects.
Item 1. A cheilitis improving agent containing Angelica sinensis extract.
Item 2. The cheilitis improving agent according to Item 1, which is an oral medication.
Item 3. The agent for improving cheilitis according to Item 1 or 2, which is used for exfoliative cheilitis.

The present invention provides a drug that can improve cheilitis.

This is a photo of the lips before and after taking Angelica extract. This is a photo of the lips after taking Angelica sinensis extract.

The cheilitis improving agent of the present invention is characterized by containing Angelica sinensis extract and being used to improve cheilitis. The cheilitis improving agent of the present invention is described in detail below.

As the herbal prescription for Angelica sinensis extract , the herbal prescription described in "New Guide to General Herbal Prescriptions" (supervised by Yukihiro Goda and Takashi Hakamzuka, edited by the Japanese Association of Herbal Medicine Preparations, published by Jiho Co., Ltd.) is preferred, specifically including mixed herbal medicines consisting of Angelica sinensis, Peony root, Cnidium officinale, Scutellaria baicalensis, Bougainvillea Root, Rehmannia Root, Astragalus Root, Polygala Root, and Licorice Root. In addition, Angelica sinensis includes mixed herbal medicines (herbal prescriptions) described in currently widely used letters related to herbal medicine, as stipulated in the "Basic Handling Policy for Herbal Medicine Preparations" established by the Kampo Herbal Medicine Research Committee.

The amounts of each herb that makes up Angelica Root in Angelica Root are 2.5 to 10 parts by weight, preferably 3 to 7 parts by weight; Peony Root ...

Suitable examples of herbal medicine preparations used in the manufacture of the Angelica Root extract used in the present invention include 5 parts by weight of Angelica Root, 3 parts by weight of Peony Root, 3 parts by weight of Cnidium Root, 3 parts by weight of Citrus Fruit, 3 parts by weight of Bougainvillea Root, 4 parts by weight of Rehmannia Root, 1.5 parts by weight of Astragalus Root, 1.5 parts by weight of Polygala Root, 2 parts by weight of Polygala Root, and 1 part by weight of Licorice Root.

The form of the extract of Angelica sinensis may be either a liquid extract such as a liquid extract or a soft extract, or a solid dried extract powder.

A liquid extract of Angelica sinensis can be obtained by extracting the mixed herbs according to the Angelica sinensis prescription and concentrating the resulting extract as necessary. A dried Angelica sinensis extract powder can be obtained by drying the liquid extract.

In the production of the extract of Angelica sinensis, the extraction solvent used in the extraction process is not particularly limited, and may be water or aqueous ethanol. The extraction process of Angelica sinensis is not particularly limited, and may be, for example, a method in which the total weight (converted to dry weight) of the herbal medicine contained in Angelica sinensis is extracted with an extraction solvent in an amount of about 5 to 10 times, and then the mixture is concentrated to 1/2 the volume, and the solids are removed to obtain a liquid extract of Angelica sinensis. This liquid extract can be dried to obtain a dried extract powder of Angelica sinensis. The drying process is not particularly limited, and may be any known method, such as a spray drying method or a method in which a suitable adsorbent (e.g., silicic anhydride, starch, etc.) is added to a soft extract with a high extract concentration to obtain an adsorbed powder.

When using an extract as a toki-in-shi in the present invention, the extract prepared by the method described above may be used, or a commercially available extract may be used.

In the cheilitis improving agent of the present invention, the content of Angelica sinensis extract is not particularly limited as long as the effect of the present invention is achieved, but is usually 5 to 100% by weight, preferably 10 to 90% by weight, more preferably 20 to 80% by weight, and even more preferably 30 to 60% by weight, calculated as the amount of dried extract powder of Angelica sinensis extract. In the present invention, the amount of dried extract powder of Angelica sinensis refers to the amount of the dried extract powder itself when a dried extract powder of Angelica sinensis is used, and refers to the amount converted to the amount remaining after removing the solvent when a liquid extract of Angelica sinensis is used. In addition, when the dried extract powder of Angelica sinensis contains additives such as adsorbents added during production, the amount refers to the amount excluding the additives.

Other components The cheilitis improving agent of the present invention may be composed of Angelica sinensis extract alone, or may contain additives and bases according to the formulation. Such additives and bases are not particularly limited as long as they are pharmacologic acceptable, and examples thereof include excipients, binders, disintegrants, lubricants, isotonicity agents, plasticizers, dispersants, emulsifiers, solubilizers, wetting agents, stabilizers, suspending agents, adhesives, coating agents, glossing agents, water, oils and fats, waxes, hydrocarbons, fatty acids, higher alcohols, esters, water-soluble polymers, surfactants, metal soaps, lower alcohols, polyhydric alcohols, pH adjusters, buffers, antioxidants, UV inhibitors, preservatives, flavorings, fragrances, powders, thickeners, dyes, and chelating agents. These additives may be used alone or in combination of two or more. The content of these additives and bases is appropriately set according to the types of additives and bases used, the formulation form of the cheilitis improving agent, and the like.

In addition, the cheilitis improving agent of the present invention may contain other nutritional components and pharmacological components as necessary in addition to the Angelica sinensis extract. Such nutritional components and pharmacological components are not particularly limited as long as they are pharmacologic acceptable, but examples thereof include antacids, stomachic agents, digestive agents, intestinal regulators, antispasmodics, mucosal repair agents, anti-inflammatory agents, astringents, antiemetics, antitussives, expectorants, anti-inflammatory enzymes, sedatives, hypnotics, antihistamines, caffeine, cardiac diuretics, antibacterial agents, vasoconstrictors, vasodilators, local anesthetics, herbal extracts, vitamins, and menthols. These nutritional components and pharmacological components may be used alone or in combination of two or more. The content of these components is appropriately set depending on the type of components used and the formulation form of the cheilitis improving agent.

The formulation form of the cheilitis improving agent of the present invention is not particularly limited, but preferably includes formulation forms that can be orally administered, such as solid formulations such as powders, fine granules, granules (including dry syrup), tablets, pills, capsules (soft capsules, hard capsules), etc.; semi-solid formulations such as jellies; and liquid formulations such as liquids, suspensions, syrups, etc. Among these formulation forms, solid formulations are preferred from the viewpoints of the stability and portability of the contained ingredients.

To prepare the cheilitis improving agent of the present invention in the above-mentioned formulation form, the agent may be formulated according to the usual formulation method used in the pharmaceutical field using Angelica sinensis extract, and additives, bases, and/or pharmacological ingredients that are added as necessary.

The cheilitis improving agent of the present invention is used for the purpose of improving cheilitis. Cheilitis is not particularly limited, and examples thereof include exfoliative cheilitis, contact cheilitis, and actinic cheilitis, and among these, exfoliative cheilitis is preferred.

In addition, since the cheilitis improving agent of the present invention can improve cheilitis that occurs on the lips, which have a rich number of capillaries and a high blood flow, its application can also include people who have cheilitis but do not fall under the category of "blood deficiency," such as those who are not anemic or prone to cold.

Dosage and Usage: The dosage form of the cheilitis improving agent of the present invention is not particularly limited, but is preferably administered orally. The dosage of the cheilitis improving agent of the present invention is appropriately set according to the age, sex, constitution, and severity of symptoms of the person to be administered, but for example, the amount of about 0.5 to 20 g, preferably about 1 to 10 g, more preferably about 2 to 6 g, and even more preferably about 2 to 4 g of the dried extract powder of Angelica sinensis extract per person per day may be taken 1 to 3 times a day, preferably 2 or 3 times a day. The timing of taking the agent is not particularly limited, and may be before, after, or between meals, but it is preferable to take the agent before (30 minutes before a meal) or between meals (2 hours after a meal).

The present invention will be described in detail below with reference to examples, but the present invention is not limited to these examples.

The raw herbs used for the production of Angelica sinensis extract powder were 5 parts by weight of Angelica sinensis , 3 parts by weight of Peony root, 3 parts by weight of Cnidium officinale, 3 parts by weight of Scutellaria baicalensis, 3 parts by weight of Bougainvillea Root, 4 parts by weight of Rehmannia Root, 1.5 parts by weight of Astragalus Root, 1.5 parts by weight of Astragalus Root, 2 parts by weight of Polygala Root, and 1 part by weight of Licorice Root, which were then chopped and extracted with 20 times the weight of water (540 parts by weight) at about 100°C for 1 hour, centrifuged to obtain an extract, which was concentrated under reduced pressure and dried using a spray dryer to obtain Angelica sinensis extract powder. The obtained Angelica sinensis extract powder was 10.8g per 100g of raw herbal mixture. The drying using a spray dryer was performed by dropping the extract into an atomizer rotating at 10,000 rpm and supplying hot air at 150°C.

Test Example: Ten subjects with exfoliative cheilitis (none of whom had symptoms of poor circulation or anemia) were given 2.85 g of Angelica sinensis extract powder per day (equivalent to the amount of dried extract, taken three times a day after meals) for one week.

The area of chapped lips (pixels ² ) was calculated using a face image analyzer VISIA (Nuskin Japan Co., Ltd.) before and after taking the drug. The results showed that the area of chapped lips before taking the drug was an average of 6,773 pixels ² , while the area of chapped lips after taking the drug was only an average of 639 pixels ^2. In other words, taking Angelica sinensis extract powder significantly improved exfoliative cheilitis.

Furthermore, for one of the subjects, photographs of the lips before and after administration are shown in Figure 1 (before administration; rough area 8,258 pixels ² ) and Figure 2 (after administration; rough area 399 pixels ² ). As shown in the figure, the exfoliative cheilitis of this subject was almost completely cured after only one week of administration of Angelica sinensis.

Furthermore, when subjects were asked to complete a questionnaire to assess their experience of improvement in their cheilitis, 90% of them answered that they were satisfied or somewhat satisfied.

Claims (1)

An oral medication containing Angelica sinensis extract that is used to treat exfoliative cheilitis.