JP7613474B2 - Drug emulsification equipment - Google Patents

Description

The present disclosure relates to a pharmaceutical emulsification device, and in particular to a pharmaceutical emulsification device used for preparing an emulsion formulation for injection.

In some cases, a formulation for injection is prepared by suspending and emulsifying an aqueous drug and an oil-based drug. For example, in the case of a vaccine, an aqueous vaccine formulation may be mixed and emulsified with an oil-based adjuvant to promote immune responses. As a method for emulsifying a small amount of drug, a method using two syringes and an emulsification filter is known (see, for example, Patent Document 1). By connecting a syringe containing an aqueous drug and a syringe containing an oil-based drug with an emulsification filter in between, and pumping alternately, both drugs can be mixed and emulsified.

JP 2005-186026 A

However, to emulsify using this method, it is necessary to transfer the drug solution from the vial to the syringe using a syringe with an attached transfer needle, and then remove the transfer needle from the syringe and attach it to the emulsification filter. In this case, when attaching each syringe to the emulsification filter, the inside of the syringe becomes an open system, which may cause leakage of the contents.

The objective of the present disclosure is to realize a drug emulsification device that can emulsify a drug contained in a vial without the need to change syringes.

One aspect of the drug emulsification device disclosed herein includes a first syringe connection part and a second syringe connection part, each of which is connected to a syringe; a flow path switching part that switches between a first connection state in which the first syringe connection part and the second syringe connection part are not connected to each other and a second connection state in which the first syringe connection part and the second syringe connection part are connected to each other; a first vial connection part that is connected to the first syringe connection part and not connected to the second syringe connection part in the first connection state; and an emulsification filter located in a flow path that connects the first syringe connection part and the second syringe connection part in the second connection state.

According to one embodiment of the drug emulsification device, by switching the flow path, emulsification can be performed sequentially by moving the drug between syringes, greatly improving operability.

One aspect of the drug emulsification device may further include a second vial connection part that is connected to the second syringe connection part and not connected to the first syringe connection part in the first connection state. With this configuration, the drug can be moved from each vial to each syringe to perform emulsification.

One embodiment of the pharmaceutical emulsification device may further include an identification mark that allows the first vial connection part and the second vial connection part to be distinguished from each other. With this configuration, it is possible to reduce the likelihood of failure of the emulsification operation due to mistaking the vial connection part.

In one aspect of the drug emulsification device, the first vial connection part and the second vial connection part each have a transfer needle that is inserted into the stopper, and the transfer needle may have an air vent filter. With this configuration, the internal pressure of the vial does not change when injecting the dissolving solution into the vial or extracting the liquid from the vial, making the operation easier. It also makes it easier to remove air bubbles from the syringe that has transferred the drug.

In one aspect of the drug emulsification device, the flow path switching unit is a four-way stopcock that switches between a first connection state and a second connection state by rotating the rotating unit by a predetermined angle, and may have a rotation limiting unit that limits the rotation of the rotating unit to a predetermined angle or more. This configuration makes it less likely that the device will be operated in an incorrect flow path connection state.

In one aspect of the drug emulsification device, a prefilled syringe containing a drug can be connected to the second syringe port.

The drug emulsification device disclosed herein allows drug emulsification without the need to change syringes.

FIG. 1 is a schematic diagram showing a drug emulsifying device according to one embodiment. FIG. 2 is a schematic diagram showing a state in which a vial and a syringe are attached to a drug emulsifying device according to one embodiment. FIG. 3 is an exploded perspective view showing an example of a flow path switching unit. FIG. 4 is a perspective view showing a transfer needle. FIG. 5 is a cross-sectional view of a transfer needle. 6(a) to (d) are schematic diagrams sequentially showing an emulsification operation using a drug emulsification device according to one embodiment. FIG. 7 is a plan view showing an example of a package of a drug emulsifying device according to one embodiment. FIG. 8 is a perspective view showing a modified example of the flow path switching portion. FIG. 9 is an exploded perspective view showing a modified example of the flow path switching portion.

As shown in Figures 1 and 2, a drug emulsification device 100 according to one embodiment includes a first vial connection portion 111 and a second vial connection portion 112, a first syringe connection portion 113 and a second syringe connection portion 114, a flow path switching portion 115, and an emulsification filter 116.

The flow path switching unit 115 can switch between a first connection state in which the first flow path 141 connects the first vial connection portion 111 and the first syringe connection portion 113 and the second flow path 142 connects the second vial connection portion 112 and the second syringe connection portion 114, and a second connection state in which the first flow path 141 connects the first syringe connection portion 113 and the second syringe connection portion 114 and the second flow path 142 connects the first vial connection portion 111 and the second vial connection portion 112.

In this embodiment, the emulsification filter 116 is disposed between the first syringe connection portion 113 and the first flow path 141. Therefore, in the first connection state, the emulsification filter 116 is located between the first syringe connection portion 113 and the first vial connection portion 111, and in the second connection state, the emulsification filter 116 is located between the first syringe connection portion 113 and the second syringe connection portion 114. The emulsification filter 116 can be disposed in another position as long as it is not between the second vial connection portion 112 and the second syringe connection portion 114 in the first connection state, but is between the first syringe connection portion 113 and the second syringe connection portion 114 in the second connection state.

A first vial 211 containing a first drug is connected to the first vial connection part 111, and a second vial 212 containing a second drug is connected to the second vial connection part 112. In this embodiment, an example will be described in which the first drug is an aqueous drug such as a vaccine, and the second drug is an oil-based drug such as an adjuvant.

The flow path switching unit 115 may have any configuration as long as it is capable of switching between the first connection state and the second connection state, but may be, for example, a four-way stopcock 120 as shown in Figure 3.

The four-way stopcock 120 shown in Figure 3 has a cylindrical main body 125 and a plug portion 126 inserted into the opening of the main body 125. A plug cap 127 with an outer diameter larger than the opening of the main body 125 is formed on the upper part of the plug portion 126, and a handle 128 with four arms extending in a flat cross shape is provided on the upper part of the plug cap 127. The plug portion 126, which is the rotating part, can be rotated by gripping and rotating the handle 128.

Connection ports protrude in four directions from the main body 125. The four connection ports include a first male connector 121 and a second male connector 122, and a first female connector 123 and a second female connector 124. The first female connector 123 is disposed adjacent to the first male connector 121 and the second female connector 124. In this embodiment, the first male connector 121 and the second male connector 122 have a locking collar 135, and the first female connector 123 and the second female connector 124 have a locking male screw 134.

The plug portion 126 is formed with a first flow path 141 and a second flow path 142. When the plug portion 126 is in a first rotation position, the first flow path 141 connects the first male connector 121 and the first female connector 123, and the second flow path 142 connects the second male connector 122 and the second female connector 124, resulting in a first connection state. When the plug portion 126 is rotated 90° from the first rotation position to a second rotation position, the first flow path 141 connects the first male connector 121 and the second male connector 122, and the second flow path 142 connects the first female connector 123 and the second female connector 124, resulting in a second connection state.

The handle 128 and the connection ports are arranged so that the four arms of the handle 128 overlap with the four connection ports in the first rotation position and the second rotation position. In this way, it is easy to notice when the plug portion 126 is misaligned from the first rotation position and the second rotation position, making it difficult to cause erroneous operation. However, the handle 128 is not limited to this configuration.

A plurality of protrusions 131 are formed on the upper portion of the main body 125, protruding radially outward so as to abut against a protrusion 132 provided on the lower end of the plug cap 127. The protrusions 131 and the protrusions 132 function as a rotation limiting portion that prevents the plug portion 126 from rotating more than 90°.

In this embodiment, a transfer needle 150 is connected to the first male connector 121 and the second male connector 122, which become the first vial connection part 111 and the second vial connection part 112. A filter unit including an emulsification filter 116 is connected to the first female connector 123, which becomes the first syringe connection part 113, and the second female connector 124 becomes the second syringe connection part 114.

The transfer needle 150 may be of any type as long as it can be connected to a vial containing a drug, but may be configured as shown in Figures 4 and 5. The transfer needle 150 shown in Figures 4 and 5 has a needle 151 that is inserted into a stopper 214 made of rubber or the like that seals the opening of the vial, a female connector 152 provided at the base of the needle 151, and a cover 153 that surrounds the needle 151.

The needle 151 has a liquid passage 161 connecting the first opening 155 and the female connector 152, and an air passage 162 connected to a second opening 156 located closer to the tip of the needle 151 than the first opening 155. The air passage 162 communicates with the outside of the transfer needle 150 via an air filter 163 at the base of the needle 151. When injecting liquid into the vial or withdrawing liquid from the vial, air enters and leaves through the air filter 163 and the air passage 162. This makes it easy to inject liquid into the vial and withdraw liquid from the vial.

The cover 153 has a tongue-shaped portion 164 that is pushed open by the crimp top of the vial, and is formed to fit over the mouth of the vial. In addition, the tongue-shaped portion 164 is formed with a step portion 165 that engages with the lower end of the crimp top, and once fitted over the vial, it is configured not to easily come off. By providing such a mechanism to prevent the vial from falling off, it is possible to prevent the vial from falling off during operation, and the operator can concentrate on operating the syringe, thereby reducing the burden on the operator. However, the mechanism to prevent the vial from falling off is not limited to this configuration as long as it can prevent the vial from falling off. In addition, the mechanism to prevent the vial from falling off may be provided as necessary, and may not be provided.

The transfer needle 150 of this embodiment is connected to the male connector of the four-way stopcock 120, which is the flow path switching unit 115, by the female connector 152. The female connector 152 of the transfer needle 150 is provided with a male thread 158, and the collar 135 provided on the first male connector 121 and the second male connector 122 of the four-way stopcock 120 can be screwed into it. By making the connection between the flow path switching unit 115 and the transfer needle 150 a luer lock structure, the flow path switching unit 115 and the transfer needle 150 can be firmly connected. The transfer needle 150 may be separable from the flow path switching unit 115, or may not be separable from it. When it is made to be inseparable, for example, the collar 135 and the male thread 158 may be bonded or welded. In addition, the connection between the flow path switching unit 115 and the transfer needle 150 does not need to be a luer lock structure, and may be connected by a connector that does not have a locking mechanism. Furthermore, the flow path switching unit 115 and the transfer needle 150 may be connected without a connector, or the flow path switching unit 115 and the transfer needle 150 may be molded integrally.

In this embodiment, the emulsifying filter 116 is a filter unit housed in a housing having a male connector and a female connector. The male connector of the filter unit is connected to the first female connector 123 of the four-way stopcock 120, which is the flow path switching unit 115. The male connector of the filter unit and the first female connector 123 may be separable, or may be bonded or welded so as to be inseparable. The connection between the filter unit and the connection port of the flow path switching unit 115 may have a luer lock structure. Furthermore, the emulsifying filter 116 may not be an independent filter unit, but may be incorporated into the housing of the flow path switching unit 115.

The emulsification filter 116 may be any type capable of forming an emulsion of the first drug and the second drug, and may be, for example, an inorganic or organic porous membrane. Among them, a porous glass filter with a pore size of about 0.05 μm to 20 μm is preferable. When forming an O/W emulsion in which oil droplets are dispersed in the aqueous phase, a hydrophilic filter may be used, and in the case of a porous glass filter, it is preferable to subject the filter surface to a hydrophilic treatment. When forming a W/O emulsion in which water droplets are dispersed in the oil phase, a hydrophobic filter may be used, and in the case of a porous glass filter, it is preferable to subject the filter surface to a hydrophobic treatment. The size of the emulsification filter 116 depends on the amount of drug to be processed, but for normal injection drugs, it can be about 5 mm to 10 mm in diameter.

The first syringe 221 and the second syringe 222 are connected to the first syringe connection part 113 and the second syringe connection part 114, respectively. The first syringe 221 and the second syringe 222 are preferably, but not limited to, syringes having lock collars. By screwing the lock collar of the syringe into the male thread provided on the syringe connection part, it is possible to make it difficult for the syringe to come off during operation. It is also possible to use a syringe with a laminated gasket that is less likely to expand due to oil, or a two-piece syringe without a gasket. By using such a syringe, it is possible to improve oil resistance and sliding properties.

The drug emulsification device 100 of this embodiment can be used, for example, as follows. First, as shown in Fig. 6(a), a first vial 211 containing a dry aqueous drug is connected to the first vial connection part 111, and a second vial 212 containing an oily drug is connected to the second vial connection part 112. Also, a first syringe 221 containing a solution of the first drug is connected to the first syringe connection part 113, and a second syringe 222 is connected to the second syringe connection part 114.

6(b), the flow path switching unit 115 is set to the first connection state, and the dissolving liquid in the first syringe 221 is pushed out and moved into the first vial 211 to dissolve the first drug. Note that if the first drug has been dissolved in advance, no dissolving operation of the drug is required.

6(c), while the flow path switching unit 115 is in the first connection state, the dissolved first drug in the first vial 211 is moved into the first syringe 221. Also, the second drug in the second vial 212 is moved into the second syringe 222. Since the transfer needle 150 of this embodiment has an air passage 162 having an air filter 163, air bubbles in the syringe can be easily removed when the drug is moved from the vial to the syringe.

6(d), the flow path switching unit 115 is set to the second connection state, and the first syringe 221 and the second syringe 222 are alternately pumped to mix the first drug and the second drug while passing them through the emulsification filter 116 to form an emulsion. After that, the mixed drug is contained in the first syringe 221 or the second syringe 222, and after removing it from the flow path switching unit, a needle is attached to the tip of the syringe and inserted subcutaneously or the like.

In the above, an example has been shown in which the first drug is aqueous, the second drug is oil-based, the emulsifying filter 116 is hydrophobic, and the aqueous first drug passes through the emulsifying filter 116 first to form a W/O emulsion. However, it is also possible to form an O/W emulsion by making the first drug oil-based, the second drug aqueous, and the emulsifying filter 116 hydrophilic. In this case, a vial containing an oil-based drug may be connected to the first vial connecting portion 111, and a vial containing an aqueous drug may be connected to the second vial connecting portion 112. Alternatively, a vial containing an aqueous drug may be connected to the first vial connecting portion 111, a vial containing an oil-based drug may be connected to the second vial connecting portion 112, and the emulsifying filter may be connected between the second syringe connecting portion 114 and the flow path switching portion 115.

When emulsifying using the drug emulsifying device 100 of this embodiment, it is important to connect the first vial 211 to the first vial connecting part 111 and the second vial 212 to the second vial connecting part 112. For this reason, it is preferable to provide an identification mark so that the first vial connecting part 111 and the second vial connecting part 112 can be easily identified. The identification mark may be any type of character display, symbol display, color display, etc., and multiple displays may be combined. In addition, the identification mark may be, for example, an attached sticker indicating the vial or contents to be connected to the vial connecting part. Furthermore, by displaying on both the vial connecting part side and the vial side, erroneous connection can be prevented. For example, by attaching a similar sticker to the vial connecting part side and the vial, the user can easily grasp the combination of the vial connecting part and the vial, making it difficult to cause erroneous operation.

The identification marking is not limited to a sticker, and does not have to be provided directly on the first vial connection part 111 and the second vial connection part 112. For example, the first vial connection part 111 and the second vial connection part 112 can be identified by providing some kind of marking at the position on the first vial connection part 111 side or the position on the second vial connection part 112 side of the flow path switching part 115. Information for identification can also be written on an attached document or the like. It is also possible to set the shape of the vial connection part and the vial so that the second vial 212 cannot be attached to the first vial connection part 111 and the first vial 211 cannot be attached to the second vial connection part 112.

Furthermore, when a product is made by putting a pharmaceutical emulsifying device and a vial in one package, the arrangement of each component in the package can be fixed to prevent erroneous connection. For example, as shown in FIG. 7, in the package 301, the first vial connection part 111 and the first vial 211 are parallel, and the second vial connection part 112 and the second vial 212 are parallel. In this way, the user can be guided to connect the first vial 211 to the first vial connection part 111 and the second vial 212 to the second vial connection part 112. For example, the arrangement of each component in the package 301 can be fixed by providing a recessed part cut out in the shape of each component in the cushion material. In FIG. 7, the vial is arranged so as to be parallel to the vial connection part in order to reduce the size of the package 301, but the vial can also be arranged on the extension line of the vial connection part. Also, the package may be provided with an indication such as an arrow showing the connections between the items to be connected to guide the user.

From the viewpoint of preventing erroneous operation, it is preferable to make it possible to easily grasp the connection state of the flow path switching unit 115. When the flow path switching unit 115 is a four-way stopcock 120 as shown in FIG. 3, the two arms that correspond to the first flow path 141 of the handle 128 can be provided with a first flow path indicator 128a colored in a first color, and the two arms that correspond to the second flow path 142 can be provided with a second flow path indicator 128b colored in a second color. In this way, it is possible to easily grasp whether the flow path switching unit 115 is in the first connection state or the second connection state. The first flow path indicator 128a and the second flow path indicator 128b are not limited to color-coded indication, but can be indicated by symbols or letters, or a combination of these. In addition to this, various indications that make it easy to grasp the connection state can be made. For example, a linear indication part connecting the 128a can be provided to indicate the flow path.

The flow path switching unit 115 may be a vertical four-way stopcock 180 as shown in Figures 8 and 9. The four-way stopcock 180 has a first male connector 181 and a second female connector 184 on a first surface, and a second male connector 182 and a first female connector 183 on a second surface. In the first connection state of the four-way stopcock 180, the first male connector 181 and the first female connector 183 are connected, and the second male connector 182 and the second female connector 184 are connected. In the second connection state, the first male connector 181 and the second male connector 182 are connected, and the first female connector 183 and the second female connector 184 are connected.

The four-way stopcock 180 has a rotating part 193 sandwiched between an upper support 192 and a lower support 194 housed in a housing formed by a cylindrical case 195 with an opening on the side and a cover 191. The side opening of the housing is provided within a central angle of 90°. The case 195 is provided with a first male connector 181 and a second female connector 184, and the cover 191 is provided with a second male connector 182 and a first female connector 183.

The first male connector 181 and the second female connector 184 are disposed in opposing positions across the center of the case 195, and the second male connector 182 and the first female connector 183 are disposed in opposing positions across the center of the cover 191. When the cover 191 is attached to the case 195, the line connecting the first male connector 181 and the second female connector 184 and the line connecting the second male connector 182 and the first female connector 183 are perpendicular to each other.

The upper support 192 and the lower support 194 are disk-shaped and are fixed in position in the housing. The upper support 192 has through holes at positions corresponding to the second male connector 182 and the first female connector 183, and the lower support 194 has through holes at positions corresponding to the first male connector 181 and the second female connector 184.

The rotating part 193 is provided with a first flow path 141 and a second flow path 142. The first flow path 141 and the second flow path 142 are circumferential grooves that penetrate the rotating part 193 and are provided in a range of a central angle of 90°, and are provided at positions opposite to the center of the rotating part 193. The rotating part 193 has a lever 196 that protrudes radially outward. The lever 196 protrudes outward from a side opening of the housing, and the rotating part 193 can be rotated by operating the lever 196.

In the vertical four-way stopcock 180, the side opening of the housing opens in a range of a central angle of 90°, and the rotation angle of the rotating part 193 is limited to 90°. When the lever 196 is abutted against one end of the side opening, a first connection state is established in which the first flow path 141 connects the first male connector 181 and the first female connector 183, and the second flow path 142 connects the second male connector 182 and the second female connector 184. When the lever 196 is rotated 90° until it abuts against the other end of the side opening, a second connection state is established in which the first flow path 141 connects the first male connector 181 and the second male connector 182, and the second flow path 142 connects the first female connector 183 and the second female connector 184.

As an example of a vertical four-way stopcock, the connection between the connectors is switched by rotating a rotating plate provided with a flow path. However, it is also possible to use a four-way stopcock that has two connectors each in a case and a cover, as described in U.S. Patent 6,319,465, and switches the connection of the connectors by rotating the cover 180 degrees relative to the case.

Even when a vertical four-way stopcock 180 is used, it is possible to provide a distinguishing mark for the first vial connection part 111 and the second vial connection part 112. It is also possible to provide a distinguishing mark for the first connection state and the second connection state.

The flow path switching unit 115 may have any configuration as long as it can connect the first vial connection unit 111 to the first syringe connection unit 113 and the second vial connection unit 112 to the second syringe connection unit 114 in the first connection state, and can connect the first syringe connection unit 113 to the second syringe connection unit 114 and the first vial connection unit 111 to the second vial connection unit 112 in the second connection state.

The flow path switching unit 115 may have a locking mechanism that prevents the first connection state from being returned to once it has been switched from the first connection state to the second connection state. By providing a locking mechanism, it is possible to prevent operational errors such as returning the drug moved to the syringe side to the vial side again. In addition, a clicking sensation is generated when switching, which indicates to the user that the second connection state has been entered.

Various configurations can be considered when providing a locking mechanism, but in the case of a four-way stopcock as shown in Figure 3, for example, a locking mechanism can be easily formed by providing a claw-shaped portion near the protrusion 131 of the main body 125 that the convex portion 132 can overcome in only one direction.

From the viewpoint of reducing the dead volume, it is preferable that the distance between the first vial connection part 111 and the first syringe connection part 113, between the second vial connection part 112 and the second syringe connection part 114, and between the first syringe connection part 113 and the second syringe connection part 114 is as short as possible. For this reason, it is preferable that no other members such as tubes are present between the flow path switching part 115 and the vial connection part and the syringe connection part. In addition, it is preferable that the flow path inside the flow path switching part 115 is as short as possible.

In this embodiment, the operation of connecting two vials containing medicine and transferring each medicine from the vial to a syringe to perform emulsification has been described. However, one of the syringes can be a prefilled syringe in which the medicine has been placed beforehand. By making one of the syringes a prefilled syringe, the emulsification operation can be simplified. The medicine to be placed in the prefilled syringe is preferably an aqueous medicine. When using a prefilled syringe, only one vial connection part can be provided. In addition, the flow path switching part can be one that switches three flow paths rather than one that switches four flow paths. In addition, when the flow path switching part is one that switches four flow paths, a cartridge connection part can be provided in addition to the syringe connection part, the vial connection part, and the prefilled syringe connection part, and the mixed medicine can be stored in a cartridge and the cartridge can be set in an administration device to administer the medicine subcutaneously or the like.

When one of the syringes is a prefilled syringe, it is preferable to provide an identification mark so that the side to which the prefilled syringe is connected can be easily identified. Various marks can be used for the identification mark of the syringe connection part, as with the identification mark of the vial connection part. In addition, the shape of the connection part of the prefilled syringe and the connection part of the normal syringe can be made different so that it can only be connected to the correct syringe connection part.

The drug emulsification device disclosed herein can emulsify drugs contained in a vial without the need to change syringes, making it useful in the medical field, etc.

100 Drug emulsification device 111 First vial connection part 112 Second vial connection part 113 First syringe connection part 114 Second syringe connection part 115 Flow path switching part 116 Emulsification filter 120 Four-way stopcock 121 First male connector 122 Second male connector 123 First female connector 124 Second female connector 125 Main body part 126 Plug part 127 Plug cap 128 Handle 128a First flow path indication 128b Second flow path indication 131 Protrusion 132 Convex part 134 Male screw 135 Collar 141 First flow path 142 Second flow path 150 Transfer needle 151 Needle 152 Female connector 153 Cover 155 First opening 156 Second opening 158 Male screw 161 Liquid passage 162 Air passage 163 Ventilation filter 164 Tongue-shaped portion 165 Step portion 180 Four-way stopcock 181 First male connector 182 Second male connector 183 First female connector 184 Second female connector 191 Cover 192 Upper support 193 Rotating portion 194 Lower support 195 Case 196 Lever 211 First vial 212 Second vial 214 Stopper 221 First syringe 222 Second syringe 301 Package

Claims (6)

a first syringe connection portion and a second syringe connection portion to which a syringe is connected,
a flow path switching unit that switches between a first connection state in which the first syringe connection portion and the second syringe connection portion are not connected to each other and a second connection state in which the first syringe connection portion and the second syringe connection portion are connected to each other;
a first vial connection portion that is connected to the first syringe connection portion and is not connected to the second syringe connection portion in the first connection state;
an emulsification filter located in a flow path that connects the first syringe connection part and the second syringe connection part in the second connection state. The drug emulsification device according to claim 1, further comprising a second vial connection portion that is connected to the second syringe connection portion and not connected to the first syringe connection portion in the first connection state. The pharmaceutical emulsification device of claim 2, further comprising an identification marking that allows identification of the first vial connection portion and the second vial connection portion. The first vial connection portion and the second vial connection portion each have a transfer needle that is inserted into a vial containing a drug;
The drug emulsifying device according to claim 2 or 3, wherein the transfer needle has an air passage provided with an air filter. The drug emulsification device according to any one of claims 1 to 4, wherein the flow path switching unit is a stopcock that switches between the first connection state and the second connection state by rotating a rotating unit through a predetermined angle, and has a rotation limiting unit that limits the rotation of the rotating unit so that it does not rotate beyond the predetermined angle. The drug emulsification device according to claim 1, wherein a prefilled syringe containing a drug is connected to the second syringe connection part.

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