JP7618939B2 - Nutraceutical Compositions - Google Patents

Description

The present invention relates to a nutritional supplement composition and a method for producing the same, a method for suppressing the unpleasant odor of a nutritional supplement composition, and a composition for suppressing the unpleasant odor of a nutritional supplement composition.

In recent years, due to irregular eating habits and growing awareness of beauty, there has been an increasing demand for nutritional supplement compositions, such as dietary supplements containing amino acids, vitamins, minerals, and other nutrients, in order to efficiently replenish necessary nutrients.

The nutritional supplement composition contains various components (hereinafter sometimes referred to as "raw materials"), and it is known that some of the raw materials themselves have an unpleasant odor. Such odors pose a problem in that they reduce the product value of the nutritional supplement composition.

Vitamin B1, for example, is known as a component whose raw material itself has a problematic odor.
As techniques for reducing the odor of vitamin B1, for example, a technique of incorporating chondroitin sulfate (see, for example, Patent Document 1) and a technique of incorporating fermented cellulose (see, for example, Patent Document 2) have been proposed.

In addition, as a deodorizing substance that can be used for food applications, for example, a deodorizing substance has been proposed that is a fraction obtained by passing a raw material selected from sweet potato juice and molasses derived from sweet potatoes through a column packed with a synthetic adsorbent as a fixed carrier, and eluting the components adsorbed by the synthetic adsorbent with a solvent selected from water, methanol, ethanol, and mixtures thereof (see, for example, Patent Document 3).

As mentioned above, various technologies that can prevent the decline in product value of nutritional supplement compositions and the like are currently being investigated.

JP 2011-231051 A JP 2011-250716 A Japanese Patent Application Publication No. 10-151182

The inventors have found that a nutritional supplement composition containing at least one compound selected from the vitamin B group and an amino acid or a salt thereof gives off an unpleasant odor that is different from the odor of the raw materials themselves and that is perceived as unpleasant by humans, when stored, particularly in a hot and humid environment. The hot and humid environment corresponds, for example, to a summer environment.

The present invention aims to solve the above-mentioned problems and achieve the following objectives. That is, the present invention aims to provide a nutritional supplement composition that can suppress the unpleasant odor that occurs when a nutritional supplement composition containing at least one compound selected from the vitamin B group and an amino acid or a salt thereof is stored, particularly when stored in a high temperature and high humidity environment, and a method for producing the same, a method for suppressing the unpleasant odor of a nutritional supplement composition, and a composition for suppressing the unpleasant odor of a nutritional supplement composition.

In order to solve the above problems, the present inventors conducted extensive research and discovered that, by simply adding at least one type of dietary fiber selected from the group consisting of sugarcane-derived dietary fiber, citrus-derived dietary fiber, oat-derived dietary fiber, wheat-derived dietary fiber, inulin, isomalt, dextrin, and cornstarch to a nutritional supplement composition containing at least one compound selected from the B vitamin group and an amino acid or a salt thereof, it is possible to reduce the unpleasant odor caused by the coexistence of at least one compound selected from the B vitamin group and an amino acid or a salt thereof, even when the composition is stored in a high-temperature, high-humidity environment.

The present invention is based on the findings of the present inventors, and the means for solving the above problems are as follows.
<1> (A) at least one compound selected from the vitamin B group;
(B) an amino acid or a salt thereof;
(C) A nutritional supplement composition characterized by containing at least one type of dietary fiber selected from the group consisting of sugar cane-derived dietary fiber, citrus-derived dietary fiber, oat-derived dietary fiber, wheat-derived dietary fiber, inulin, isomalt, dextrin, and corn starch.
<2> The nutritional supplement composition according to <1>, wherein the component (C) includes at least one selected from the group consisting of dietary fiber derived from sugarcane, dietary fiber derived from citrus, dietary fiber derived from oats, and dietary fiber derived from wheat.
<3> The nutritional supplement composition according to any one of <1> to <2>, wherein the component (C) contains dietary fiber derived from sugar cane.
<4> The nutritional supplement composition according to any one of <1> to <3>, wherein the (A) at least one compound selected from the B vitamin group contains vitamin B1 and vitamin B6.
<5> The nutritional supplement composition according to <4>, wherein the mass ratio of the total amount of vitamin B1 and vitamin B6 in the component (A) to the amino acid or a salt thereof in the component (B), [{(vitamin B1)+(vitamin B6)}/(amino acid or a salt thereof)], is greater than 0.1.
<6> The nutritional supplement composition according to any one of <1> to <5>, wherein the mass ratio of the total amount of the at least one compound selected from the vitamin B group of the component (A) to the amino acid or a salt thereof of the component (B) {(the total amount of the at least one compound selected from the vitamin B group)/(amino acid or a salt thereof)} is more than 0.1.
<7> A method for producing a nutritional supplement composition, comprising a mixing step of mixing (A) at least one compound selected from the vitamin B group, (B) an amino acid or a salt thereof, and (C) at least one dietary fiber selected from the group consisting of sugarcane-derived dietary fiber, citrus-derived dietary fiber, oat-derived dietary fiber, wheat-derived dietary fiber, inulin, isomalt, dextrin, and corn starch.
<8> The mixing step includes a first mixing treatment of mixing the at least one compound selected from the vitamin B group (A) with the at least one dietary fiber selected from the group consisting of sugar cane-derived dietary fiber, citrus-derived dietary fiber, oat-derived dietary fiber, wheat-derived dietary fiber, inulin, isomalt, dextrin, and corn starch;
The method for producing the nutritional supplement composition described in <7> above includes a second mixing process in which the mixture obtained in the first mixing process is mixed with the (B) amino acid or a salt thereof.
<9> A method for suppressing an unpleasant odor of a nutritional supplement composition containing (A) at least one compound selected from the vitamin B group and (B) an amino acid or a salt thereof, comprising:
The method for suppressing unpleasant odors includes a mixing step of mixing (A) at least one compound selected from the vitamin B group, (B) the amino acid or a salt thereof, and (C) at least one dietary fiber selected from the group consisting of sugarcane-derived dietary fiber, citrus-derived dietary fiber, oat-derived dietary fiber, wheat-derived dietary fiber, inulin, isomalt, dextrin, and corn starch.
<10> The mixing step includes a first mixing treatment of mixing the at least one compound selected from the vitamin B group (A) with the at least one dietary fiber selected from the group consisting of sugar cane-derived dietary fiber, citrus-derived dietary fiber, oat-derived dietary fiber, wheat-derived dietary fiber, inulin, isomalt, dextrin, and corn starch;
The method for suppressing an unpleasant odor according to <9> above, further comprising a second mixing treatment in which the mixture obtained in the first mixing treatment is mixed with the amino acid or a salt thereof (B).
<11> A method for suppressing an unpleasant odor of a nutritional supplement composition containing at least one compound selected from the vitamin B group and an amino acid or a salt thereof,
The unpleasant odor suppressing composition is characterized by containing at least one type of dietary fiber selected from the group consisting of sugarcane-derived dietary fiber, citrus-derived dietary fiber, oat-derived dietary fiber, wheat-derived dietary fiber, inulin, isomalt, dextrin, and corn starch.

The present invention can solve the above-mentioned problems and achieve the above-mentioned object, and can provide a nutritional supplement composition that can suppress the unpleasant odor that occurs when a nutritional supplement composition containing at least one compound selected from the vitamin B group and an amino acid or a salt thereof is stored, particularly when stored in a high temperature and high humidity environment, a method for producing the same, a method for suppressing the unpleasant odor of a nutritional supplement composition, and a composition for suppressing the unpleasant odor of a nutritional supplement composition.

(Nutritional Supplement Composition)
The nutritional supplement composition of the present invention contains at least (A) at least one compound selected from the B vitamin group (hereinafter, sometimes referred to as "component (A)"), (B) an amino acid or a salt thereof (hereinafter, sometimes referred to as "component (B)"), and (C) at least one dietary fiber selected from the group consisting of sugar cane-derived dietary fiber, citrus-derived dietary fiber, oat-derived dietary fiber, wheat-derived dietary fiber, inulin, isomalt, dextrin, and corn starch (hereinafter, sometimes referred to as "component (C)" or "specific dietary fiber"), and further contains other components as necessary.

<(A) At least one compound selected from the vitamin B group>
In the present invention, the vitamin B group compounds refer to vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, vitamin B9, and vitamin B12. These may be used alone or in combination of two or more.
As the vitamin B group compound, commercially available products can be appropriately used.

Of the B vitamin compounds, the nutritional supplement composition preferably contains vitamin B1 and vitamin B6.

The vitamin B1 includes thiamine and its derivatives, and salts thereof.
The derivatives are not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include bisthiamine, thiamine disulfide, dicethiamine, fursultiamine, octotiamine, shikotiamine, bis-ibutiamine, bis-bentiamine, prosultiamine, benfotiamine, and thiamine diphosphate.
The salt is not particularly limited and can be appropriately selected depending on the purpose. Examples of the salt include inorganic acid salts such as nitrates, hydrochlorides, and sulfates.
The vitamin B1 may be used alone or in combination of two or more kinds.

The vitamin B2 includes riboflavin and its derivatives, and salts thereof.
The derivative is not particularly limited and can be appropriately selected depending on the purpose. Examples of the derivative include riboflavin phosphate, riboflavin butyrate, and flavin adenine dinucleotide.
The salt is not particularly limited and can be appropriately selected depending on the purpose. Examples of the salt include alkali metal salts such as sodium salts.
The vitamin B2 may be used alone or in combination of two or more kinds.

The vitamin B3 includes nicotinic acid, nicotinamide and derivatives thereof, and salts thereof.
The derivative is not particularly limited and can be appropriately selected depending on the purpose. Examples of the derivative include inositol hexanicotinate, nicotinamide adenine dinucleotide, nicotinamide adenine dinucleotide phosphate, and hepronicate.
The salt is not particularly limited and can be appropriately selected depending on the purpose.
The vitamin B3 may be used alone or in combination of two or more kinds.

The vitamin B5 includes pantothenic acid and its derivatives, as well as salts thereof.
The derivative is not particularly limited and can be appropriately selected depending on the purpose. Examples of the derivative include panthenol, pantethin, pantetheine, coenzyme A, and the like.
The salt is not particularly limited and can be appropriately selected depending on the purpose. Examples of the salt include alkali metal salts such as sodium salts, and alkaline earth metal salts such as calcium salts.
The vitamin B5 may be used alone or in combination of two or more kinds.

The vitamin B6 includes pyridoxine, pyridoxamine, pyridoxal, and derivatives thereof, and salts thereof.
The derivative is not particularly limited and can be appropriately selected depending on the purpose. Examples of the derivative include pyridoxal phosphate.
The salt is not particularly limited and can be appropriately selected depending on the purpose. Examples of the salt include alkaline earth metal salts such as calcium salts, and inorganic acid salts such as hydrochlorides.
The vitamin B6 may be used alone or in combination of two or more kinds.

The vitamin B7 includes biotin and its salts.
The salt is not particularly limited and can be appropriately selected depending on the purpose. Examples of the salt include alkali metal salts such as sodium salts.
The vitamin B7 may be used alone or in combination of two or more kinds.

The vitamin B9 includes folic acid and its derivatives, and salts thereof.
The derivative is not particularly limited and can be appropriately selected depending on the purpose. Examples of the derivative include dihydrofolic acid and tetrahydrofolic acid.
The salt is not particularly limited and can be appropriately selected depending on the purpose.
The vitamin B9 may be used alone or in combination of two or more kinds.

The vitamin B12 includes cyanocobalamin, hydroxocobalamin, adenosylcobalamin, methylcobalamin, and derivatives thereof, and salts thereof.
The derivative is not particularly limited and can be appropriately selected depending on the purpose. Examples of the derivative include mecobalamin and deoxyadenosylcobalamin.
The salt is not particularly limited and can be appropriately selected depending on the purpose. Examples of the salt include inorganic acid salts such as hydrochloride salts and organic acid salts such as acetate salts.
The vitamin B12 may be used alone or in combination of two or more kinds.

The content of the (A) component in the nutritional supplement composition is not particularly limited and can be appropriately selected depending on the purpose, but the total amount of the (A) component is preferably 1 part by mass or more, more preferably 10 parts by mass or more, and particularly preferably 20 parts by mass or more, per 100 parts by mass of the nutritional supplement composition. If the content is within the preferred range, it is advantageous in that the intake amount for the purpose of component supplementation can be met.

When the nutritional supplement composition contains multiple types of B vitamin compounds, the content ratio of each of the B vitamin compounds is not particularly limited and can be appropriately selected depending on the purpose.

<(B) Amino acid or salt thereof>
The amino acid or a salt thereof is not particularly limited and can be appropriately selected depending on the purpose.
The salt of the amino acid is not particularly limited and can be appropriately selected depending on the purpose. Examples of the salt include salts with inorganic or organic acids such as hydrochloride, sulfate, acetate, etc., and salts with bases such as sodium salt, potassium salt, etc.
The amino acids or salts thereof may be used alone or in combination of two or more.
As the amino acid or a salt thereof, a commercially available product can be appropriately used.

Among the amino acids or salts thereof, the amino acids are preferably leucine, threonine, proline, valine, isoleucine, methionine, phenylalanine, tryptophan, lysine, asparagine, aspartic acid, serine, histidine, glycine, arginine, glutamic acid, alanine, cysteine (including cystine, the same applies below), tyrosine, glutamine, and citrulline, more preferably leucine, valine, isoleucine, phenylalanine, serine, histidine, glycine, arginine, glutamic acid, alanine, cysteine, tyrosine, glutamine, and citrulline, and particularly preferably leucine. The nutritional supplement composition containing the preferred amino acids or salts thereof is prone to generating the unpleasant odor, but according to the present invention, the unpleasant odor can be suppressed.

The content of the (B) component in the nutritional supplement composition is not particularly limited and can be appropriately selected depending on the purpose, but the total amount of the (B) component is preferably 0.1 to 70 parts by mass, more preferably 1 to 60 parts by mass, and particularly preferably 2 to 50 parts by mass, per 100 parts by mass of the nutritional supplement composition. If the content is within the preferred range, it is advantageous in that the intake amount for the purpose of component supplementation can be met.

When the nutritional supplement composition contains multiple types of amino acids or salts thereof, the content ratio of each compound of the amino acids or salts thereof is not particularly limited and can be appropriately selected depending on the purpose.

The mass ratio (A)/(B) of the component (A) to the component (B) is not particularly limited and can be appropriately selected depending on the purpose.
For example, when the (A) component contains vitamin B1 and vitamin B6, the mass ratio [{(vitamin B1) + (vitamin B6)} / (B component)] of the total amount of vitamin B1 and vitamin B6 to the total amount of the (B) component is not particularly limited and can be appropriately selected according to the purpose, but is preferably more than 0.1, more preferably 1 or more, and particularly preferably 2.5 or more. In addition, the mass ratio [(total amount of (A) component) / (total amount of (B) component)] of the total amount of the (A) component to the total amount of the (B) component is not particularly limited and can be appropriately selected according to the purpose, but is preferably more than 0.1, more preferably 1 or more, and particularly preferably 2.5 or more. The nutritional supplement composition in the preferred range is prone to generate the unpleasant odor, but according to the present invention, the unpleasant odor can be suppressed.

The total content of the (A) component and the (B) component in the nutritional supplement composition is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 4.9 parts by mass or more, more preferably 10 parts by mass or more, and particularly preferably 20 parts by mass or more, per 100 parts by mass of the nutritional supplement composition. The nutritional supplement composition within the preferred range is prone to generating the unpleasant odor, but according to the present invention, the unpleasant odor can be suppressed.

<(C) Specific dietary fiber>
The component (C) is at least one type of dietary fiber selected from the group consisting of sugar cane-derived dietary fiber, citrus-derived dietary fiber, oat-derived dietary fiber, wheat-derived dietary fiber, inulin, isomalt, dextrin, and corn starch.
The component (C) is blended in order to suppress unpleasant odors that arise when at least one compound selected from the vitamin B group and an amino acid or a salt thereof coexist.
The dietary fiber refers to indigestible components contained in food that cannot be digested by human digestive enzymes.

Among the (C) components, an embodiment containing at least one selected from the group consisting of dietary fiber derived from sugarcane, dietary fiber derived from citrus, dietary fiber derived from oats, and dietary fiber derived from wheat is preferred, and an embodiment containing dietary fiber derived from sugarcane is more preferred, in that it has an excellent effect of suppressing unpleasant odors caused by the coexistence of at least one compound selected from the vitamin B group and an amino acid or a salt thereof.

The sugarcane-derived dietary fiber, the citrus-derived dietary fiber, the oat-derived dietary fiber, and the wheat-derived dietary fiber may contain dietary fiber derived from each plant, and may be in the form of only dietary fiber separated and purified from each plant, or may be in the form of a processed product of each plant containing dietary fiber. The processed product is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include crushed products.
The sugar cane-derived dietary fiber, the citrus-derived dietary fiber, the oat-derived dietary fiber, and the wheat-derived dietary fiber are preferably water-insoluble dietary fibers.
The water-insoluble dietary fiber is mainly composed of structural substances in the cell walls of plants, and is insoluble in water and has water retention properties.

The component (C) may be a commercially available product or may be prepared from plant materials by a known method.

The content of the (C) component in the nutritional supplement composition is not particularly limited and can be appropriately selected depending on the purpose, but the total amount of the (C) component is preferably 0.1 parts by mass or more, more preferably 1 to 85 parts by mass, and particularly preferably 3 to 50 parts by mass, per 100 parts by mass of the nutritional supplement composition. If the content is within the preferred range, it is advantageous in that the unpleasant odor suppression effect is more excellent.

When the nutritional supplement composition contains multiple types of the (C) component, the content ratio of each of the (C) components is not particularly limited and can be appropriately selected depending on the purpose.

The mass ratio of the (C) component to the (A) component {(C)/(A)} is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.001 to 100, more preferably 0.01 to 50, and particularly preferably 0.1 to 10. If the mass ratio is within the preferred range, it is advantageous in that the unpleasant odor suppression effect is more excellent.

<Other ingredients>
The other components in the nutritional supplement composition are not particularly limited as long as they do not impair the effects of the present invention, and can be appropriately selected depending on the purpose. For example, the other components may be vitamins other than vitamin B group, such as vitamin A, vitamin C, vitamin D, vitamin E, hesperidin, inositol, etc.; peptide-containing substances containing milk-derived peptides such as casein hydrolysate, peptide-containing substances containing animal-derived peptides such as chicken cartilage-derived extract, peptide-containing substances containing plant-derived peptides such as maca extract and sesame extract, peptide-containing substances containing seaweed-derived peptides such as wakame extract and kombu extract, peptide-containing substances containing fish-derived peptides such as shark cartilage extract, salmon nasal cartilage extract, and tuna extract; minerals such as calcium, magnesium, zinc, iron, manganese, copper, selenium, chromium, and molybdenum; functional components such as coenzyme Q10, α-lipoic acid, L-carnitine, collagen, hyaluronic acid, elastin, turmeric, glucosamine, and chondroitin; various polyphenols. lubricants such as stearic acid, calcium stearate, magnesium stearate, sodium stearyl fumarate, sucrose fatty acid esters, vegetable fats and oils, and hardened oils; disintegrants such as partially pregelatinized starch and sodium starch glycolate; excipients such as lactose and brewer's yeast; natural polysaccharides such as pullulan, gum arabic, xanthan gum, guar gum, and alginic acid; powdered cellulose; crystalline cellulose; cellulose derivatives such as hydroxypropyl cellulose and hydroxypropyl methylcellulose; water-soluble polymers such as polyvinylpyrrolidone and polyvinyl alcohol; sugar alcohols such as reduced maltose syrup, xylitol, sorbitol, mannitol, and maltitol; disaccharides such as trehalose and palatinose; soybean polysaccharides; binders such as corn protein; fixing agents; colorants such as titanium oxide and iron oxide; pH adjusters or buffers such as phytic acid, citric acid, succinic acid, sodium citrate, sodium acetate, DL-malic acid, phosphoric acid, and disodium phosphate; and antioxidants. These may be used alone or in combination of two or more.
As the other components, commercially available products can be appropriately used.
The contents of other components in the nutritional supplement composition are not particularly limited and can be appropriately selected depending on the purpose.

The form of the nutritional supplement composition is not particularly limited and may be appropriately selected depending on the purpose. For example, the form may be (i) a mixture containing the component (A), the component (B), and the component (C); (ii) a mixture containing the component (A) and the component (C), and a mixture containing the component (B); (iii) a mixture containing the component (B) and the component (C), and a mixture containing the component (A); (iv) a mixture containing at least one compound of the component (A) and the component (C), and a mixture containing at least one compound of the component (A) other than the component (A) contained in the mixture, and the component (B).
Among these, in terms of their superior unpleasant odor suppression effect, (ii) a mixture containing the component (A) and the component (C), and a mixture containing the component (B), and (iv) a mixture containing at least one compound of the component (A) and the component (C), and a mixture containing at least one compound of the component (A) excluding the component (A) contained in the mixture, and the component (B) are preferred.
In the above-mentioned aspects, in "a mixture containing the component (A) and the component (C)" and "a mixture containing at least one compound of the component (A) and the component (C)", the component (A) or at least one compound of the component (A) is preferably at least one of vitamin B1 and vitamin B6, and more preferably vitamin B1.
The mixture may be in the form of granules or powder.

The form of the nutritional supplement composition is not particularly limited and can be appropriately selected depending on the purpose. Examples of the form include powder, granules, and tablets.
The shape, structure and size of the powder, granules and tablets are not particularly limited and can be appropriately selected depending on the purpose.

The nutritional composition may be used as a nutritional supplement or a supplement, or may be used as a raw material for producing granules or tablets.

According to the present invention, it is possible to reduce unpleasant odors that occur during storage, particularly during storage in hot and humid environments such as summer, without impairing the physiologically active functions of the nutrients contained in the nutritional supplement composition.
Furthermore, the nutritional supplement composition of the present invention can be suitably produced by the method for producing the nutritional supplement composition of the present invention described below, and is also excellent in terms of production costs.

(Method of producing nutritional supplement composition)
The method for producing the nutritional supplement composition of the present invention includes at least a mixing step, and may further include other steps as necessary.

<Mixing step>
The mixing step is a step of mixing (A) at least one compound selected from the vitamin B group, (B) an amino acid or a salt thereof, and (C) at least one dietary fiber selected from the group consisting of sugarcane-derived dietary fiber, citrus-derived dietary fiber, oat-derived dietary fiber, wheat-derived dietary fiber, inulin, isomalt, dextrin, and corn starch.
In the mixing step, other components may be further mixed, if necessary.

The (A) component, the (B) component, the (C) component, and the other components in the mixing step are the same as those described in the (nutritional supplement composition) section of the present invention above, and the preferred embodiments are also the same.

In the mixing step, the (A) component, the (B) component, the (C) component, and, if necessary, the other components may be mixed together in one step, or may be mixed in several steps.

The mixing step preferably includes a first mixing step of mixing the component (A) with the component (C), and a second mixing step of mixing the mixture obtained in the first mixing step with the component (B). This preferred embodiment is advantageous in that it is possible to further suppress unpleasant odors caused by the coexistence of the component (A) and the component (B).
In each mixing step, components other than those described above may be mixed as necessary. In addition, in the second mixing step, the component (A) may be further added. The component (A) added in the second mixing step may be the same as or different from the component (A) in the first mixing step.

The mixture in the mixing step may be in the form of a powder or granules.
The mixing step can produce a nutritional supplement composition in the form of powder or granules.

The mixing can be carried out using a known device, such as a container tumbler, a V-type mixer, or a Bohle container mixer.
The mixing conditions such as temperature and time are not particularly limited and can be appropriately selected depending on the purpose.

The granulation method is not particularly limited, and any known method can be appropriately selected. Examples of the method include a fluidized bed granulation method, an agitation granulation method, and a dry granulation method.
Specific examples of the granulation method include a method in which the components are kneaded, mixed, and/or stirred, and then an appropriately selected binder is sprayed thereon.

The binder is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include cellulose derivatives such as hydroxypropylmethylcellulose, hydroxypropylcellulose, and methylcellulose, thickening polysaccharides such as pullulan and guar gum, and sugar alcohols such as isomaltose, xylitol, maltitol, and sorbitol. These may be used alone or in combination of two or more.
As the binder, commercially available products can be appropriately used.

The binder is preferably in the form of a solution or dispersion (hereinafter sometimes referred to as a "spray liquid") in order to be sprayed.
The solvent used to dissolve or disperse the binder is not particularly limited and can be appropriately selected depending on the type of binder used, and examples thereof include water, ethanol, and a mixture thereof.

The viscosity of the spray liquid and the concentration of the binder in the spray liquid (solids concentration) are not particularly limited and can be appropriately selected depending on the purpose.
The method for spraying the spray liquid is not particularly limited and can be appropriately selected depending on the purpose. For example, the spray liquid can be sprayed from a spraying means provided in the granulation device used, such as a spray gun or a spray nozzle.
The spray conditions (spray amount, size of mist particles to be sprayed, spray time, spray interval, etc.) are not particularly limited, and known conditions can be appropriately selected.

The granulation can be carried out using a known device, and examples of the device include a spray granulator, a fluidized bed granulator, and an agitation granulator.
The conditions of the granulation, such as temperature and time, are not particularly limited and can be appropriately selected depending on the purpose.

<Other processes>
The other steps are not particularly limited as long as they do not impair the effects of the present invention, and can be appropriately selected depending on the purpose. For example, a tableting step can be included.

The tableting process is a process of tableting the powder obtained by mixing the powder or granules obtained in the mixing process with other ingredients as necessary, thereby making a nutritional supplement composition in the form of a tablet.

The tableting can be carried out using known equipment, such as tablet presses (e.g., HT-APSS type, HT-AP-MS type, HT-X-SS type, HT-X-MS type (all manufactured by Hata Iron Works Co., Ltd.); VEL5, VIRGO, AQUARIUS, LIBRA (all manufactured by Kikusui Seisakusho Co., Ltd.)).

There are no particular limitations on the conditions for tableting, such as the tableting pressure, and these can be selected appropriately depending on the purpose.

The method for producing a nutritional supplement composition of the present invention makes it possible to efficiently produce a nutritional supplement composition that can reduce unpleasant odors that occur during storage, particularly during storage in high temperature and high humidity environments such as summer.

(Method for suppressing unpleasant odors)
The method for suppressing an unpleasant odor of the present invention is a method for suppressing an unpleasant odor of a nutritional supplement composition containing (A) at least one compound selected from the B vitamin group and (B) an amino acid or a salt thereof, which includes at least a mixing step and, if necessary, further includes other steps.

<Mixing step>
The mixing step is a step of mixing (A) at least one compound selected from the vitamin B group, (B) an amino acid or a salt thereof, and (C) at least one dietary fiber selected from the group consisting of sugarcane-derived dietary fiber, citrus-derived dietary fiber, oat-derived dietary fiber, wheat-derived dietary fiber, inulin, isomalt, dextrin, and corn starch, and can be carried out in the same manner as described in the <Mixing step> section of (Method for producing a nutritional supplement composition) of the present invention above, and the preferred embodiments are also the same.

<Other processes>
The other steps are not particularly limited as long as they do not impair the effects of the present invention, and can be appropriately selected depending on the purpose. For example, the other steps may be similar to those described in the <Other steps> section of the above-mentioned (Method for producing a nutritional supplement composition) of the present invention.

The unpleasant odor suppression method of the present invention can reduce unpleasant odors that occur during storage of a nutritional supplement composition, particularly during storage in a hot and humid environment such as in the summer.

(Composition for suppressing unpleasant odor)
The unpleasant odor suppressing composition of the present invention is used to suppress the unpleasant odor of a nutritional supplement composition containing at least one compound selected from the B vitamin group and an amino acid or a salt thereof, and is derived from sugar cane. dietary fiber derived from citrus, dietary fiber derived from oats, dietary fiber derived from wheat, inulin, isomalt, dextrin, and corn starch, and if necessary It may further contain other ingredients as required.

<At least one type of dietary fiber selected from the group consisting of sugarcane-derived dietary fiber, citrus-derived dietary fiber, oat-derived dietary fiber, wheat-derived dietary fiber, inulin, isomalt, dextrin, and corn starch>
The at least one type of dietary fiber selected from the group consisting of sugar cane-derived dietary fiber, citrus-derived dietary fiber, oat-derived dietary fiber, wheat-derived dietary fiber, inulin, isomalt, dextrin, and corn starch is the same as that described in the section (C) Specific dietary fiber of the (nutritional supplement composition) of the present invention above, and preferred embodiments are also the same.

The content of at least one type of dietary fiber selected from the group consisting of sugarcane-derived dietary fiber, citrus-derived dietary fiber, oat-derived dietary fiber, wheat-derived dietary fiber, inulin, isomalt, dextrin, and cornstarch in the unpleasant odor suppression composition is not particularly limited and can be appropriately selected depending on the purpose. The unpleasant odor suppression composition may consist of only at least one type of dietary fiber selected from the group consisting of sugarcane-derived dietary fiber, citrus-derived dietary fiber, oat-derived dietary fiber, wheat-derived dietary fiber, inulin, isomalt, dextrin, and cornstarch.

<Other ingredients>
The other ingredients are not particularly limited and can be appropriately selected depending on the purpose. For example, they may be the same as those described in the <Other ingredients> section of the (nutritional supplement composition) of the present invention described above.

The unpleasant odor suppression composition can reduce unpleasant odors that occur during storage of a nutritional supplement composition containing at least one compound selected from the vitamin B group and an amino acid or a salt thereof, particularly during storage in a hot and humid environment such as in summer.

The present invention will be specifically explained below with reference to test examples, but the present invention is not limited to these test examples.

(Test Example 1)
<Test Example 1-1>
Various vitamins and leucine in the amounts shown in Table 1-1 below were mixed in a polyethylene bag, and then 1 g of water was added and mixed to obtain a mixture.
The polyethylene bag containing the mixture was sealed and left to stand in a thermostatic chamber at 60°C for one day, after which a sensory evaluation of the unpleasant odor generated was carried out as follows. Note that the unpleasant odor does not refer to the odor of the raw material itself, but rather to the odor generated after the standing (the same applies below). The evaluation was carried out by three people, and the average values are shown in Table 1-1 below.
- Sensory evaluation -
3 points: Strong unpleasant odor.
2 points: Unpleasant odor.
1 point: Slightly unpleasant odor.
0 points: No unpleasant odor.
Details of the vitamins and leucine used are as follows:
Vitamin A (dry vitamin A acetate 326,000 IU/g, manufactured by BASF Japan Ltd.; the same applies below)
Vitamin B1 (vitamin B1 nitrate, manufactured by BASF Japan Ltd.; the same applies below)
Vitamin B2 (Riboflavin FP, manufactured by BASF Japan Ltd.; the same applies below)
Vitamin B6 (pyridoxine hydrochloride, manufactured by BASF Japan Ltd.; the same applies below)
Vitamin C (ascorbic acid 100M, manufactured by BASF Japan Ltd.; the same applies below)
Vitamin D (Dry Vitamin D3, manufactured by Mitsubishi Chemical Foods Corporation; the same applies below)
Vitamin E (Riken Dry E Mix F-20S, manufactured by Riken Vitamin Co., Ltd.; the same applies below)
- Leucine (L-leucine, manufactured by Ajinomoto Healthy Supply Co., Ltd.; the same applies below)

The results in Table 1-1 confirm that an unpleasant odor occurs when vitamin B group compounds and leucine coexist.

<Test Example 1-2>
A vitamin B group compound and leucine in the amounts shown in Table 1-2 below were mixed in a polyethylene bag, and then water in the amount shown in Table 1-2 below was added and mixed to obtain a mixture.
The polyethylene bag containing the mixture was sealed and allowed to stand in a thermostatic chamber at 60° C. for one day, after which a sensory evaluation for the unpleasant odor generated was carried out as follows.
[Sensory evaluation]
The unpleasant odor of Test Example 1-2-1 was scored as 10 points (control), and the unpleasant odor was evaluated on an 11-point scale ranging from 0 points (no unpleasant odor) to 10 points (strong unpleasant odor). The evaluation was performed by three people, and the average values are shown in Table 1-2 below.

The results in Table 1-2 confirm that an unpleasant odor occurs even when the mass ratio of the vitamin B group compound (component (A)) to leucine (component (B)) is changed, and that the unpleasant odor becomes particularly strong when the mass ratio {component (A)/component (B)} exceeds 0.1.

<Test Example 1-3>
In a polyethylene bag, 3.0 g of vitamin B1, 3.0 g of vitamin B6, and 2.0 g of each of the amino acids or salts thereof shown in Tables 1-3 below were mixed, and then 1.0 g of water was added and mixed to obtain a mixture.
The polyethylene bag containing the mixture was sealed and allowed to stand in a thermostatic chamber at 60° C. for one day, after which a sensory evaluation for the unpleasant odor generated was carried out as follows.
[Sensory evaluation]
The unpleasant odor of Test Example 1-3-1 was scored as 10 points (control), and the unpleasant odor was evaluated on an 11-point scale from 0 points (no unpleasant odor) to 10 points (strong unpleasant odor). The evaluation was performed by six people, and the average values are shown in Table 1-3 below.

The results in Table 1-3 confirm that an unpleasant odor is also produced when an amino acid or its salt other than leucine coexists with a vitamin B group compound.

(Test Example 2)
<Test Example 2-1>
- Preparation of granules -
Vitamin B1 in the amounts shown in Tables 2-1 to 2-3 below was mixed with the following additive ingredients in a stirring and mixing granulator (VGmm, manufactured by Powrex Corporation), and then water in the amounts shown in Tables 2-1 to 2-3 below was added dropwise to granulate until the mixture became granular, thereby obtaining a granulated product.
The granules were dried (shelf dry, 60° C.) and sieved through a 16 mesh sieve to obtain granule samples.
[Additives]
・ Dietary fiber (sugarcane fiber (Sugarcane Fiber, manufactured by Rettenmaier Japan Co., Ltd., the same applies below)
・ Dietary fiber (sugarcane powder (Uji Powder, manufactured by Okinawa Powder Foods Co., Ltd., the same applies below)
・ Sugarcane extract (Sugarcane extract, manufactured by Mitsui Sugar Co., Ltd.; the same applies below)

- Preparation and evaluation of the mixture -
Each of the granule samples or vitamin B1, leucine, and vitamin B6 in the amounts shown in Tables 2-4 to 2-6 below were mixed in a polyethylene bag, and then water in the amount shown in Tables 2-4 to 2-6 below was added dropwise while mixing to obtain a mixture.
The polyethylene bag containing the mixture was sealed and allowed to stand in a thermostatic chamber at 60° C. for 4 days, after which a sensory evaluation for the unpleasant odor generated was carried out as follows.
[Sensory evaluation]
The unpleasant odor of Test Example 2-1-1 was scored as 10 points (control), and the unpleasant odor was evaluated on an 11-point scale from 0 points (no unpleasant odor) to 10 points (strong unpleasant odor). The evaluation was performed by six people, and the average values are shown in Tables 2-4 to 2-6 below.

<Test Example 2-2>
- Preparation of granules -
Vitamin B1 and dietary fiber (sugarcane fiber) in the amounts shown in Table 2-7 below were mixed in a stirring and mixing granulator (VGmm, manufactured by Powrex Corporation), and then water in the amount shown in Table 2-7 below was added dropwise to granulate until the mixture became granular, thereby obtaining a granulated product.
The granules were dried (shelf dry, 60° C.) and sieved through a 16 mesh sieve to obtain granule samples.

- Preparation and evaluation of the mixture -
Each of the granule samples or vitamin B1, leucine, and vitamin B6 in the amounts shown in Table 2-8 below were mixed in a polyethylene bag, and then water in the amount shown in Table 2-8 below was added dropwise while mixing to obtain a mixture.
The polyethylene bag containing the mixture was sealed and allowed to stand in a thermostatic chamber at 60° C. for 4 days, after which a sensory evaluation for the unpleasant odor generated was carried out as follows.
[Sensory evaluation]
The unpleasant odor of Test Example 2-2-1 was scored as 10 points (control), and the unpleasant odor was evaluated on an 11-point scale from 0 points (no unpleasant odor) to 10 points (strong unpleasant odor). The evaluation was performed by six people, and the average values are shown in Table 2-8 below.

The results of Test Example 2 confirmed that the use of sugarcane-derived dietary fiber can suppress the unpleasant odor that occurs when B vitamin compounds and amino acids coexist. In addition, it was confirmed that even when the mass ratio of sugarcane-derived dietary fiber and B vitamin compounds is changed, the unpleasant odor that occurs when B vitamin compounds and amino acids coexist can be suppressed.

(Test Example 3)
- Preparation of granules -
Vitamin B1 in the amounts shown in Tables 3-1 to 3-3 below was mixed with the various dietary fibers shown below in a stirring and mixing granulation device (VGmm, manufactured by Powrex Corporation), and then water in the amounts shown in Tables 3-1 to 3-3 below was added dropwise to granulate the mixture until it became granular, thereby obtaining a granulated product.
The granules were dried (shelf dry, 60° C.) and sieved through a 16 mesh sieve to obtain granule samples.
[Dietary fiber]
・ Citrus Fiber (Helba Cell, manufactured by Herba Food Co., Ltd., the same applies below)
・ Oat fiber (Oat fiber, manufactured by Rettenmaier Japan Co., Ltd., the same applies below)
・ Wheat fiber (Wheat fiber, manufactured by Rettenmaier Japan Co., Ltd., the same applies below)
・ Inulin (Inulin, manufactured by Fuji Nippon Seito Co., Ltd., the same applies below)
- Isomalt (reduced palatinose, manufactured by Mitsui Sugar Co., Ltd.; the same applies below)
Dextrin (Pine Index #100, manufactured by Matsutani Chemical Industry Co., Ltd., the same applies below)
Maltodextrin (Pine Index #2, manufactured by Matsutani Chemical Industry Co., Ltd.; the same applies below)
- Resistant dextrin (Fibersol 2, manufactured by Matsutani Chemical Industry Co., Ltd.; the same applies below)
・ Cornstarch (Cornstarch, manufactured by Nihon Shokuhin Kako Co., Ltd., the same applies below)

- Preparation and evaluation of mixtures -
Each of the granule samples or vitamin B1, leucine, and vitamin B6 in the amounts shown in Tables 3-4 to 3-6 below were mixed in a polyethylene bag, and then water in the amount shown in Tables 3-4 to 3-6 below was added dropwise while mixing to obtain a mixture.
The polyethylene bag containing the mixture was sealed and allowed to stand in a thermostatic chamber at 60° C. for 4 days, after which a sensory evaluation for unpleasant odor generated was carried out as follows.
[Sensory evaluation]
The unpleasant odor of Test Example 3-1 was scored as 10 points (control), and the intensity of the unpleasant odor was evaluated on an 11-point scale from 0 points (no unpleasant odor) to 10 points (strong unpleasant odor). The evaluation was performed by six people, and the average values are shown in Tables 3-4 to 3-6 below.

The results of Test Example 3 confirmed that the unpleasant odor that occurs when B vitamin compounds and amino acids coexist can be suppressed even when specific dietary fibers other than sugarcane fiber are used.

(Test Example 4)
- Preparation of granules -
The components shown in Table 4-1 below were mixed in an agitation mixer (VGmm, manufactured by Powrex Corporation), and then an appropriate amount of water was added dropwise to granulate the mixture until it became granular, thereby obtaining a granulated product.
The granules were dried (shelf dry, 60° C.) and sieved through a 16 mesh sieve to obtain each granule.

- Preparation of tablet powder -
Among the ingredients shown in Table 4-2 below, the ingredients other than calcium stearate were mixed in the amounts shown in Table 4-2 below to obtain mixed powders. The mixed powders were granulated to obtain granules, to which calcium stearate was added in the amount shown in Table 4-2 below and mixed to obtain tablet powders.
The details of each component used are as follows:
Nicotinamide (Nicotinamide NT, manufactured by Vertellus Stecialtes Inc.)
Calcium pantothenate (calcium pantothenate, manufactured by DSM Nutrition Japan Co., Ltd.)
・ Inositol (Inositol, manufactured by Tsuno Rice Fine Chemicals Co., Ltd.)
・ Vitamin B12 (VB12 1000x powder, manufactured by Organo Food Tech Co., Ltd.)
・Folic acid (Folic acid, manufactured by DSM Nutrition Japan Co., Ltd.)
・ Biotin (food additive biotin 1%, manufactured by DSM Nutrition Japan Co., Ltd.)
- Crystalline cellulose (Ceolas UF-F711, manufactured by Asahi Kasei Corporation)
Calcium stearate (calcium stearate, manufactured by Sakai Chemical Industry Co., Ltd.)

-Tableting and evaluation-
Using a rotary tablet press (VEL5, manufactured by Kikusui Seisakusho Co., Ltd.), the tablet powder having the composition described in Table 4-2 was packed and compressed at a pressure of 15 kN to obtain tablets having a diameter of 10 mm, a radius of curvature (R) of 8.5 mm, and a weight of 440 mg per tablet.
The tablets were placed in an aluminum pouch and allowed to stand in an open-air constant temperature and humidity chamber at 30° C. and a relative humidity of 80% for 3 hours, after which a sensory evaluation of the unpleasant odor generated was carried out as follows.
[Sensory evaluation]
The unpleasant odor of Test Example 4-1 was scored as 10 points (control), and the intensity of the unpleasant odor was evaluated on an 11-point scale from 0 points (no unpleasant odor) to 10 points (strong unpleasant odor). The evaluation was performed by six people, and the average values are shown in Table 4-3 below.

The results of Test Example 4 confirmed that, even in the case of tablets, an unpleasant odor occurs when a vitamin B group compound and an amino acid or a salt thereof coexist. It was also confirmed that the unpleasant odor can be suppressed by using the dietary fiber of the present invention, even in the case of tablets.

Claims (6)

(A) at least one compound selected from the B vitamin group;
(B) an amino acid or a salt thereof;
(C) at least one dietary fiber selected from the group consisting of sugarcane-derived dietary fiber, citrus-derived dietary fiber, oat-derived dietary fiber, and wheat- derived dietary fiber,
The (A) at least one compound selected from the vitamin B group includes vitamin B1 and vitamin B6,
The (B) amino acid or a salt thereof includes leucine or a salt thereof,
the nutritional supplement composition is a mixture containing (i) granules containing either one of vitamin B1 and vitamin B6, and (C) at least one type of dietary fiber selected from the group consisting of dietary fiber derived from sugar cane, dietary fiber derived from citrus, dietary fiber derived from oats, and dietary fiber derived from wheat, (ii) the vitamin B1 and the vitamin B6 that are not contained in the granules, and (iii) the leucine or a salt thereof;
The nutritional supplement composition is in the form of a powder, granules, or tablet. (A) at least one compound selected from the B vitamin group;
(B) an amino acid or a salt thereof;
(C) at least one dietary fiber selected from the group consisting of sugarcane-derived dietary fiber, oat-derived dietary fiber, and wheat-derived dietary fiber,
The (A) at least one compound selected from the vitamin B group includes vitamin B1 and vitamin B6,
The (B) amino acid or a salt thereof includes leucine or a salt thereof,
The nutritional supplement composition is a mixture comprising: (i) granules containing either one of vitamin B1 and vitamin B6, and (C) at least one type of dietary fiber selected from the group consisting of dietary fiber derived from sugar cane, dietary fiber derived from oats, and dietary fiber derived from wheat; (ii) the vitamin B1 and the vitamin B6 that are not contained in the granules; and (iii) the leucine or a salt thereof . The nutritional supplement composition according to claim 2, wherein the nutritional supplement composition is in the form of a powder, granules, or tablet. The nutritional supplement composition according to any one of claims 1 to 3, wherein the component (C) contains dietary fiber derived from sugar cane. The nutritional supplement composition according to any one of claims 1 to 4, wherein the mass ratio of the total amount of vitamin B1 and vitamin B6 in the component (A) to the amino acid or a salt thereof in the component (B) [{(vitamin B1) + (vitamin B6)} / (amino acid or a salt thereof)] is greater than 0.1. The nutritional supplement composition according to any one of claims 1 to 5, wherein the mass ratio of the total amount of at least one compound selected from the vitamin B group in the component (A) to the amino acid or a salt thereof in the component (B) {(total amount of at least one compound selected from the vitamin B group)/(amino acid or a salt thereof)} is greater than 0.1.