JP7621117B2 - Oral Composition - Google Patents

Description

The present invention relates to an oral composition.

Conventionally, in order to suppress bad breath, disinfectants for killing bacteria that cause bad breath, deodorants, and generation inhibitors for suppressing the generation of substances that cause bad breath have been used, and oral compositions that combine these have been proposed.

Plant extracts are known as components for suppressing bad breath, and various oral compositions have been proposed that contain plant extracts as active ingredients for preventing bad breath (see Patent Documents 1 to 3 below). Oral compositions containing such plant extracts as active ingredients are effective in suppressing bad breath caused by components that cause bad breath, such as volatile sulfur and methyl mercaptan.

In addition, even if there is no bad breath (bad breath) that can actually be detected by others, there are an increasing number of cases where people are concerned about bad breath due to discomfort in the oral cavity, and in order to eliminate such concerns about bad breath, oral compositions have been proposed that utilize plant extracts and N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide and/or N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5-methylcyclohexanecarboxamide (see Patent Document 4 below).

JP 2005-289918 A Patent No. 5776364 JP 2016-112634 A International Publication No. 2018/221621

However, with the oral compositions disclosed in the above patent documents, even after using the oral composition and rinsing the mouth, an aftertaste derived from the plant extract remains in the mouth, and there are cases in which the user is unable to fully experience the effect of suppressing bad breath.

The object of the present invention is therefore to provide an oral composition that can suppress the unpleasant aftertaste caused by plant extracts, even when the plant extracts are used as oral odor suppressing ingredients, and that can improve the stickiness and provide an excellent refreshing feeling.

That is, the present invention provides the following [1] to [7].
[1] (A) a plant extract,
(B) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide.
[2] The oral composition described in [1], wherein (A) the plant extract is an extract of one or more plants selected from the group consisting of rosemary, Scutellaria baicalensis, carrot, sage, licorice, Angelica acutiloba, persimmon, sword bean, olive, tea, magnolia, Phellodendron amplexicaule, Japanese spicebush, Chinese pepper, thyme, white birch, peony, Quercus salicina, Asarum, turmeric, clove, stevia, Sapindus mukorossi, marjoram, melissa, perilla, laurel, eucalyptus, cola, Monk fruit, camellia, clove, allspice, Sappan, Lithospermum root, Rhubarb, Forsythia suavea, Tangerine peel, cinnamon, oregano, basil, Lonicera ulmoides, Peony seed oil, and Myrobalan.
[3] The oral composition described in [2], wherein (A) the plant extract is an extract of one or more plants selected from the group consisting of rosemary, Scutellaria baicalensis, carrot, sage, licorice, Angelica acutiloba, persimmon, sword bean, olive, tea, and Phellodendron amplexicaule.
[4] (A) containing a plant extract in an amount of 0.00001 to 0.05% by mass as a pure extract content;
(B) The oral composition according to any one of [1] to [3], containing 0.00001 to 0.1 mass% of N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide.
[5] The oral composition according to any one of [1] to [4], wherein the mass ratio of the content of (A) the plant extract (pure extract content) to the content of (B) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide is 0.02 to 100.
[6] The oral composition according to any one of [1] to [5], which is a dentifrice or a mouthwash.
[7] The oral composition according to [6], which is a dentifrice and further contains 8 to 70 mass% of an abrasive (C).

The present invention provides an oral composition that can suppress the unpleasant aftertaste caused by plant extracts even when plant extracts are used, and further improves the feeling of stickiness, thereby providing an excellent feeling of freshness.

The present invention will be described in detail below.
The oral composition of the present invention contains (A) a plant extract and (B) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, and may further contain (C) an abrasive.

First, we will explain the components (A) to (C) that can be included in the oral composition of this embodiment.

[(A) Plant Extract]
The "(A) component" according to the embodiment of the present invention is a plant extract. The plant extract is an extract obtained by extracting a plant as a raw material.

Component (A) is an ingredient that can reduce and improve the sticky feeling in the oral cavity, especially when used in combination with component (B) described below.

The plant from which component (A) is derived is preferably a plant from which a plant extract having antibacterial, deodorant, or anti-inflammatory effects can be obtained. Examples of plants from which component (A) is derived include rosemary, Scutellaria baicalensis, carrot, sage, licorice, Japanese angelica, persimmon (particularly persimmon tannin), sword bean, olive (particularly olive leaves), tea, magnolia, Phellodendron amplexicaule (particularly Phellodendron bark), Japanese spicebush, Japanese pepper, thyme, white birch, peony, Quercus salicina, Asarum japonica, turmeric, clove, stevia, Soapberry, marjoram, melissa, perilla, laurel, eucalyptus, cola, monk fruit, camellia, clove, allspice, Suo, Lithospermum ulmoides, Rhubarb, Forsythia spp., Chinese tangerine, cinnamon, oregano, basil, Lonicera japonica, Peony pi, and Myrobalan.

In this embodiment, it is preferable that component (A) is an extract of one or more plants selected from the group consisting of the above-mentioned examples of plants.

Among these, it is more preferable that component (A) is an extract of one or more plants selected from the group consisting of rosemary, Scutellaria baicalensis, carrot, sage, licorice, Angelica acutiloba, persimmon, sword bean, olive, tea, and Phellodendron amplexicaule.

The plant extracts from the plants exemplified above can be extracted using any suitable method known in the art, and can be extracted under any suitable extraction conditions known in the art.

In this embodiment, the plant extract, which is component (A), can be specifically produced by, for example, extracting the raw material, which is made by crushing the above-mentioned plants, particularly the leaves and stems, into a powder form, using a polar solvent, a nonpolar solvent, or a mixed solvent of a polar solvent and a nonpolar solvent as an extraction solvent.

Examples of extraction solvents include polar solvents such as water, ethyl ether, ethylene chloride, dioxane, acetone, ethanol, methanol, ethanol, propanol, isopropanol, ethyl acetate, propylene glycol, butylene glycol, and glycerin, and non-polar solvents such as n-hexane, petroleum ether, ligroin, cyclohexane, carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, toluene, and benzene, and mixtures of these solvents.

The extraction solvent is preferably a hydrophilic solvent, and the component (A) of the present invention is preferably a hydrophilic solvent extract. The hydrophilic solvent is preferably water, a lower monohydric alcohol having 1 to 5 carbon atoms (particularly methanol, ethanol, propanol, isopropanol, etc.), glycol (particularly propylene glycol, butylene glycol, etc.), or a mixture of these.

The mixed solvent is preferably a mixed solvent in which the mixing ratio of water to a lower monohydric alcohol or glycol is 10:90 to 90:10 (mass ratio). The extraction solvent may be composed of water only.

In addition, the extraction residue after the extraction process using the above raw material and the above extraction solvent can be used as a further raw material to produce a plant extract that is further extracted using the above extraction solvent, and can also be used as component (A). Note that a commercially available plant extract may also be used as component (A).

In this embodiment, the content of component (A) in the entire oral composition (100% by mass) is 0.00001 to 0.05% by mass, preferably 0.0001 to 0.005% by mass, and more preferably 0.0002 to 0.005% by mass, in terms of the pure extract content excluding the extraction solvent, from the viewpoint of improving the sticky feeling and suppressing irritation in the oral cavity. When the content of component (A) is 0.00001% by mass or more, the sticky feeling can be sufficiently reduced, and when it is 0.05% by mass or less, irritation in the oral cavity during use can be reduced.

[(B) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide]
The component (B) is N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide.

In this embodiment, the blending amount of component (B) is preferably 0.00001 to 0.1 mass %, and more preferably 0.00005 to 0.005 mass %, in the entire oral composition from the viewpoints of improving the stickiness, imparting a refreshing feeling, and suppressing irritation in the oral cavity and a bad aftertaste. If the content of component (B) is 0.00001 mass % or more, the stickiness can be sufficiently reduced, and if it is 0.1 mass % or less, irritation in the oral cavity during use can be reduced and the aftertaste can be improved.

[Content ratio]
-(A)/(B)-
The mass ratio of the content of the (A) component to the content of the (B) component ((A)/(B)) is 0.0001 or more, preferably 0.02 or more, and more preferably 0.1 or more. (A)/(B) is 5000 or less, preferably 100 or less, and more preferably 20 or less. By doing so, it is possible to improve the stickiness, impart a refreshing feeling, and suppress irritation in the oral cavity and a worsening aftertaste. Therefore, (A)/(B) is 0.0001 to 5000, preferably 0.02 to 100, and more preferably 0.1 to 100.

[(C) Abrasive]
The "component (C)" according to the embodiment of the present invention is an abrasive. The component (C) can be suitably used when the oral composition of the present embodiment is a dentifrice (toothpaste).

The abrasive may be either an inorganic abrasive or an organic abrasive. There is no particular restriction on the preferred RDA value (Radioactive Dentine Abrasion values) of the abrasive, but it is usually 50 or more, and particularly 50 to 200. Examples of inorganic abrasives include calcium phosphate-based compounds such as dibasic calcium phosphate dihydrate or anhydrate, monobasic calcium phosphate, tribasic calcium phosphate, and calcium pyrophosphate; abrasive silica such as precipitated silica, aluminosilicate, zirconosilicate, and titanium-bonded silica; calcium carbonate-based abrasives such as calcium carbonate; calcium hydroxide, aluminum hydroxide, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, and hydroxyapatite. Examples of organic abrasives include synthetic resin-based abrasives and polymethyl methacrylate.

In the oral composition of this embodiment, one or more of the above-listed abrasives can be blended as component (C). Among these, component (C) is preferably an inorganic abrasive, more preferably an abrasive silica mainly composed of silicate such as precipitated silica, aluminosilicate, zirconosilicate, or titanium-bonded silica, or a calcium carbonate-based abrasive, and particularly preferably an abrasive silica such as precipitated silica. As the abrasive silica, commercially available products can be used, such as Zeodent (registered trademark) 124 and Zeodent (registered trademark) 113 manufactured by Evonik Corporation, TIXOSIL (registered trademark) 73 and TIXOSIL (registered trademark) 63 manufactured by Solvay, and abrasive silica, zirconosilicate, and aluminosilicate manufactured by Taki Chemical Co., Ltd.

The abrasive silica is preferably an abrasive particle having an average particle size of 1 to 40 μm, and the BET specific surface area of the abrasive silica is preferably 80 to 250 square meters per gram. Here, the average particle size of the abrasive silica is the volume-based median diameter (D50) measured by the laser diffraction/scattering method.

The amount of the abrasive component (C) is preferably 8% by mass or more, more preferably 10% by mass or more, based on the total amount of the oral composition. In this way, it is possible to impart an appropriate viscosity, ensure good shape retention, and realize a good feeling when used. The upper limit is preferably 70% by mass or less, more preferably 50% by mass or less. This makes it possible to suppress an increase in the viscosity of the oral composition, maintain good shape retention, and realize a good feeling when used. Therefore, the content of component (A) is preferably 8 to 70% by mass, more preferably 10 to 50% by mass.

The abrasive component (C) may be in granular form, and granules may be blended as an abrasive component. The granules of component (C) may be, for example, particles obtained by granulating water-insoluble powder into granules, granules obtained by crushing silica gel, or granules obtained by using any suitable conventional binder for granulation. As the abrasive component (C), it is also possible to use a combination of abrasive particles having a particle size of 1 to 40 μm as already explained and granules.

In this specification, the content of each component is based on the amount of each component added when producing the oral composition.

[Optional ingredients]
The oral composition of the present embodiment may contain optional components other than the components (A) to (C) already described, as long as the effects of the present invention are not impaired.

If the oral composition is a toothpaste, the optional components include, for example, solvents, surfactants, sweeteners, flavorings, medicinal ingredients, oily ingredients, preservatives, humectants, binders, pH adjusters, and colorants (pigments). If the oral composition is a mouthwash, the optional components include, for example, humectants, surfactants, sweeteners, preservatives, pH adjusters, flavorings, and medicinal ingredients. The specific components are described below.

-solvent-
The oral cavity composition of the present embodiment may further contain a solvent. As the solvent, preferably, water (purified water) or ethanol can be used.

-Surfactants-
The oral composition of the present embodiment may further contain a surfactant. Examples of the surfactant that can be used in the oral composition include anionic surfactants, nonionic surfactants, and amphoteric surfactants.

Examples of anionic surfactants include alkyl sulfates, acyl amino acid salts, acyltaurine salts, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, and lauryl sulfoacetates. The alkyl and acyl groups may be either linear or branched, saturated or unsaturated, and usually have 10 to 20 carbon atoms, preferably 12 to 18, and more preferably 12 to 14. The salts may be selected from pharmacologically acceptable salts. Examples of pharmacologically acceptable salts include base addition salts and amino acid salts. Specific examples of such salts include inorganic base salts such as sodium salts, potassium salts, calcium salts, magnesium salts, and ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts, and diisopropylammonium salts; and basic amino acid salts such as arginine salts. Among these, inorganic base salts are preferred, alkali metal salts (e.g., sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

Examples of alkyl sulfates include lauryl sulfate (sodium lauryl sulfate) and myristoyl sulfate. Examples of acylamino acid salts include acyl sarcosine salts such as lauroyl sarcosine salt and myristoyl sarcosine salt; acyl glutamate salts such as lauroyl glutamate, myristoyl glutamate, and palmitoyl glutamate; acyl glycine salts such as N-lauroyl-N-methyl glycine salt and cocoyl glycine salt; acyl alanine salts such as N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl-N-methyl-β-alanine salt, and N-methyl-N-acylalanine salt; and acyl aspartate salts such as lauroyl aspartate. Examples of acyltaurine salts include lauroyl methyl taurine salt, N-methyl-N-acyltaurine salt, and N-cocoyl methyl taurine salt. Examples of α-olefin sulfonate salts include α-olefin sulfonate salts having 12 to 18 carbon atoms, such as tetradecene sulfonate salt. Other examples of anionic surfactants include hydrogenated sodium coconut fatty acid monoglyceride monosulfate and sodium lauryl sulfoacetate.

From the viewpoint of foaming and foam quality, the anionic surfactant preferably contains a sulfonic acid group, and alkyl sulfates and α-olefin sulfonates are more preferred. For example, when the oral composition is a dentifrice, the content of the anionic surfactant is preferably 0.1 to 2.5% by mass, more preferably 0.6 to 2.5% by mass, and even more preferably 1 to 2.5% by mass of the entire composition. When the oral composition is a mouthwash, the content of the anionic surfactant is preferably 0 to 1.0% by mass, more preferably 0 to 0.3% by mass of the entire composition.

Examples of nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate), alkylolamides, polyoxyethylene fatty acid esters, polyoxyethylene alkenyl ethers, glycerin fatty acid esters, sucrose fatty acid esters (e.g., maltose fatty acid esters), sugar alcohol fatty acid esters (e.g., maltitol fatty acid esters, lactitol fatty acid esters), fatty acid diethanolamides (e.g., lauric acid mono- or diethanolamide), polyoxyethylene polyoxypropylene copolymers, and polyoxyethylene polyoxypropylene fatty acid esters. The number of carbon atoms in the alkyl chain of the polyoxyethylene alkyl ether is usually 14 to 18, and the average number of moles of ethylene oxide added is usually 5 to 30 moles. The average number of moles of ethylene oxide added in polyoxyethylene hydrogenated castor oil is usually 20 to 100 moles, preferably 20 to 60 moles. The number of carbon atoms in the fatty acid of the sorbitan fatty acid ester is usually 12 to 18. The number of carbon atoms in the fatty acid of the polyoxyethylene sorbitan fatty acid ester is usually 16 to 18, and the average number of moles of ethylene oxide added is usually 10 to 40. The number of carbon atoms in the alkyl chain of the alkylolamide is usually 12 to 14. As nonionic surfactants, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, and polyoxyethylene alkyl ether are preferred.

Examples of amphoteric surfactants include betaine-type amphoteric surfactants such as alkyl dimethylamino acetate betaine (e.g., lauryl dimethylamino acetate betaine) and fatty acid amidopropyl dimethylamino acetate betaine (e.g., cocamidopropyl betaine); imidazoline-type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine salts (e.g., N-coconut fatty acid acyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine), coconut fatty acid imidazolinium betaine, and 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine; and alkyl betaines such as lauryl dimethylamino acetate betaine.

The content of the surfactant is preferably 0.1 to 5% by mass, more preferably 0.5 to 3% by mass, based on the total oral composition.

-Sweetener-
The oral composition of the present embodiment may contain any suitable sweetener known in the art in any suitable content. By including a sweetener in the oral composition, the feeling of use can be further improved.

Examples of sweeteners include saccharin, saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartine, thaumatin, aspartyl phenylalanine methyl ester, etc. As sweeteners, the above-listed sweeteners may be used alone or in combination of two or more.

-Fragrance-
The oral composition of the present embodiment may contain any suitable flavoring agent known in the art in any suitable amount. By including a flavoring agent in the oral composition, the feeling of use can be further improved.

Examples of fragrances include natural essential oils such as peppermint oil, spearmint oil, Japanese peppermint oil, anise oil, cassia oil, eucalyptus oil, wintergreen oil, mastic oil, neroli oil (orange flower oil), lemongrass oil, jasmine oil, rose oil, iris oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, laurel oil, chamomile oil, caraway oil, basil oil, marjoram oil, lemon oil, orange oil, lime oil, yuzu oil, nutmeg oil, lavender oil, paracles oil, vanilla oil, cinnamon oil, pimento oil, cassia leaf oil, perilla oil, and wintergreen oil; menthol, carvone, cinnamic aldehyde, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, sitho Fragrance components contained in the above-mentioned natural essential oils, such as ral, decanal, camphor, borneol, pinene, spilanthol, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineole, ethyl linalool, and vanillin; fragrance components, such as ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methylphenyl glycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, and ethylene glycol-1-menthyl carbonate; and various blended flavors, such as mint-based, fruit-based, and herb-based flavors, which are formed by combining several fragrance components and natural essential oils. In addition, the fragrance may be a cooling agent other than component (B), such as N-ethyl-p-menthane-3-carboxamide, menthyl lactate, menthyl monosuccinate, isopulegol, menthone glycerol ketal, N-(4-cyanomethylphenyl)-p-menthane carboxamide, 3-l-menthoxypropane-1,2-diol, 5-methyl-2-propan-2-yl-N-(2-pyridin-2-ylethyl)cyclohexane-1-carboxamide, 3-(p-menthane-3-carboxamide)ethyl acetate, and 2-isopropyl-N,2,3-trimethylbutyramide. The fragrance may be used alone or in combination of two or more of the above-listed fragrances.

-Medicinal ingredients-
Examples of medicinal ingredients include bactericidal or antibacterial agents such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, isopropylmethylphenol, zinc gluconate, zinc citrate, triclosan, thymol, hinokitiol, and lysozyme chloride; enzymes such as dextranase, mutanase, amylase, protease, and Liteque enzyme; fluorides such as sodium fluoride, sodium monofluorophosphate, and tin fluoride; anti-inflammatory agents such as ε-aminocaproic acid, allantoin, tranexamic acid, glycyrrhetinic acid stearyl, allantoin chlorohydroxyaluminum, azulene, and dihydrocholesterol. Examples of the medicinal ingredients include: anti-calculus agents; metal salts such as zinc salts, copper salts, and tin salts; condensed phosphates, ethanehydroxydiphosphonates, and other tartar preventive agents; blood flow promoters such as vitamin E (e.g., tocopherol acetate); hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, and strontium chloride; coating agents such as hydroxyethylcellulose dimethyl diallyl ammonium chloride; astringents such as vitamin C (e.g., ascorbic acid or its salts), lysozyme chloride, and sodium chloride; water-soluble copper compounds such as copper chlorophyll and copper gluconate; anti-calculus agents, amino acids such as alanine, glycine, and proline, callopeptides, and polyvinylpyrrolidone. The medicinal ingredients may be used alone or in combination of two or more. The content of the medicinal ingredients can be appropriately set to an effective amount according to the usual method.

-Oily ingredients-
Examples of oily components include hydrocarbons such as squalane, liquid paraffin, petrolatum, and microcrystalline wax; higher alcohols (e.g., alcohols having 8 to 22 carbon atoms, such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, and isostearyl alcohol); higher fatty acids (e.g., fatty acids having 8 to 22 carbon atoms, such as lauric acid, myristic acid, oleic acid, and isostearic acid), vegetable oils such as olive oil, castor oil, and coconut oil; and fatty acid esters such as isopropyl myristate.

- Preservatives -
The oral composition of the present embodiment may contain any suitable preservative known in the art in any suitable amount. By including a preservative in the oral composition, the oral composition can ensure the preservative effect.

Examples of preservatives that may be contained in the oral composition include paraoxybenzoic acid esters (e.g., methyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate), sodium benzoate, etc. Preservatives may be used alone or in combination of two or more types.

- Wetting agent -
The oral composition of the present embodiment may contain any suitable content of a conventionally known humectant. By including any humectant in the oral composition, the feeling of use can be further improved.

As the humectant, sugar alcohols and polyhydric alcohols other than sugar alcohols are preferred. Examples of sugar alcohols include sugar alcohols such as sorbitol, erythritol, maltitol, lactitol, xylitol, and reduced starch saccharification products; glycerin; and polyhydric alcohols such as ethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, and polyethylene glycol. Examples of polyethylene glycols include polyethylene glycols having an average molecular weight of 150 to 6000, and preferably polyethylene glycols having an average molecular weight of 190 to 630. Specific examples include PEG200, PEG300, PEG400, and PEG600. The content of the humectant is usually 40% by mass or less, and preferably 1 to 30% by mass, based on the entire oral composition (100% by mass). The average molecular weight is the average molecular weight described in the Quasi-Drug Raw Materials Standards 2006.

- Binding agent -
The oral composition of the present embodiment may contain any suitable conventionally known binder in any suitable content. By including any suitable binder in the oral composition, the viscosity can be optimized, and the shape retention and usability can be further improved.

The optional binder that may be contained in the oral composition includes any suitable organic binder known in the art, such as polysaccharides, cellulose-based binders (e.g., carboxymethylcellulose (CMC), hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, cationic cellulose, etc.), other polysaccharide-based thickeners (e.g., xanthan gum, guar gum, gellan gum, tragacanth gum, karaya gum, gum arabic, locust bean gum, carrageenan, sodium alginate), and synthetic water-soluble polymers (e.g., sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, polyvinyl alcohol, propylene glycol alginate). Inorganic binders such as thickening silica and aluminum silicate can also be blended.

The content of the optional organic binder is preferably 0 to 3% by mass, and more preferably 0.1 to 2% by mass, based on the total oral composition. The content of the optional inorganic binder is preferably 0 to 10% by mass, and more preferably 1 to 8% by mass.

- pH adjuster -
The oral composition of the present embodiment may contain any suitable content of a conventionally known pH adjuster. By including a pH adjuster in the oral composition, the pH stability of the oral composition can be ensured.

Examples of pH adjusters include organic acids such as phthalic acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, and lactic acid, or their salts (e.g., sodium citrate), inorganic acids such as phosphoric acid (e.g., orthophosphoric acid), or their salts (e.g., potassium salts, sodium salts, and ammonium salts), and hydroxides such as sodium hydroxide and potassium hydroxide. Examples of inorganic acid salts include disodium hydrogen phosphate and sodium dihydrogen phosphate.

The content of the pH adjuster is usually an amount that will give the oral composition a pH of 5 to 9, preferably 6 to 8.5, after addition.

In this specification, the pH value usually refers to the value measured at 25°C and 3 minutes after the start of measurement. The pH value can be measured, for example, using a pH meter (model number Hm-30S) manufactured by Toa Denpa Kogyo Co., Ltd.

- Coloring agent -
The oral composition of the present embodiment may contain any suitable colorant that is conventionally known in any suitable amount.

Examples of colorants that the oral composition may contain include natural colorants such as safflower red colorant, gardenia yellow colorant, gardenia blue colorant, perilla colorant, red koji colorant, red cabbage colorant, carrot colorant, hibiscus colorant, cacao colorant, spirulina blue colorant, and tamarind colorant, as well as legal colorants such as Red No. 2, Red No. 3, Red No. 104, Red No. 105, Red No. 106, Red No. 227, Yellow No. 4, Yellow No. 5, Green No. 3, and Blue No. 1, riboflavin, sodium copper chlorophyte, and titanium dioxide. When the oral composition contains a colorant, the content of the colorant is preferably 0.00001 to 3% by mass of the entire oral composition.

-Other optional ingredients-
The oral composition of the present embodiment may contain any suitable amount of optional components other than those described above.

Examples of other optional components that may be contained in the oral composition include polyisobutylene, polybutadiene, urethane, silicone, and natural rubber. The content of these other optional components can be appropriately set within a range that does not interfere with the effects of the present invention.

[Formulation and Use of Oral Composition]
The oral composition of the present invention can be made into any suitable dosage form known in the art by any suitable method according to conventional methods.The dosage form can be, for example, liquid (solution, emulsion, suspension, syrup, etc.), semi-solid (gel, cream, paste, etc.), solid (tablet, particulate agent, capsule, film agent, kneaded material, molten solid, waxy solid, elastic solid, soft capsule, etc.).The dosage form of the oral composition is preferably liquid or semi-solid.

The oral composition of the present invention can be widely used in oral applications. Examples of applications of the composition in a solid dosage form include lozenges, gummies, chewing gum, and dentifrices. Examples of applications of the composition in a semi-solid dosage form include toothpaste and gel dentifrices. Examples of applications of the composition in a liquid dosage form include mouthwash, liquid dentifrices, and mouth fresheners (sprays, etc.). The oral composition of the present invention is preferably used as a dentifrices (toothpaste, gel dentifrices) or mouthwash, since it reduces the sticky feeling in the oral cavity after use and the bitterness derived from plant extracts after use, and can provide a good feeling of freshness in the oral cavity after use.

[Method of producing oral composition]
The method for producing the oral composition of the present invention is not particularly limited. The oral composition can be produced by a conventional method according to the selected formulation. For example, when the oral composition is to be used as a toothpaste, the method includes first preparing the components that dissolve in the solvent, then mixing the other insoluble components, and, if necessary, further degassing the composition by, for example, reducing pressure.

The toothpaste thus obtained can be made into a product by placing it in a laminated tube, or the mouthwash in a specified container (such as a bottle).

The shape and material of the container in which the oral composition of the present invention can be stored are not particularly limited. Any suitable conventional container used for oral compositions can be used. Examples of containers include plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon.

The present invention will be specifically described below with reference to examples and comparative examples. The present invention is not limited to the following examples. Note that the values in the following tables represent mass % unless otherwise specified.

[Components used in the Examples and Comparative Examples]
First, the components used in the examples and comparative examples will be described.
-Component (A)-
(A1) Rosemary extract (manufactured by Maruzen Pharmaceutical Co., Ltd., product name: Rosemary Extract-J, extraction solvent: 50% ethanol/50% water, part used: leaves)
Manufacturer:
(A2) Scutellaria root extract (manufactured by Maruzen Pharmaceutical Co., Ltd., product name: Scutellaria root extract-J, extraction solvent: 50% ethanol/50% water, part used: root)
(A3) Carrot extract (manufactured by Maruzen Pharmaceutical Co., Ltd., product name: Carrot extract, extraction solvent: 50% ethanol/50% water, part used: root)
(A4) Sage extract (manufactured by Maruzen Pharmaceutical Co., Ltd., product name: Salvia extract, extraction solvent: 50% ethanol/50% water, part used: leaves)
(A5) Licorice extract (manufactured by Maruzen Pharmaceutical Co., Ltd., product name: Licorice extract, extraction solvent: 50% ethanol/50% water, part used: root)
(A6) Sword bean extract (manufactured by Yamada Yaken Co., Ltd., product name: AOF Sword bean extract-HBG, extraction solvent: 50% 1,3-butylene glycol/50% water, part used: seeds)
(A7) Phellodendron Amurense Extract (manufactured by Ogi Pharmaceutical Co., Ltd., product name: Phellodendron Amurense Extract, extraction solvent: water, part used: bark excluding periderm)
(A8): Angelica acutiloba extract (manufactured by Maruzen Pharmaceutical Co., Ltd., product name: Angelica acutiloba extract-JC, extraction solvent: 50% ethanol/50% water, part used: root)
(A9) Olive leaf extract (manufactured by Maruzen Pharmaceutical Co., Ltd., product name: Olive Extract-BG, extraction solvent: 50% butylene glycol/50% water, part used: leaves)
(A10) Persimmon tannin extract (manufactured by Release Science Industry Co., Ltd., product name: Pansil BA-200E-1, extraction solvent: water, part used: fruit)
(A11) Tea extract (manufactured by Maruzen Pharmaceutical Co., Ltd., product name: "Waism", extraction solvent: 80% ethanol/20% water, part used: leaves)

-Component (B)-
(B) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide (manufactured by Takasago International Corporation, trade name: Coolact (registered trademark) 370)

--Component (C)--
(C) Abrasive silica (manufactured by Solvay, trade name: Tixosil (registered trademark) 73)

Components other than components (A) to (C): N-ethyl-p-menthane-3-carboxamide: manufactured by Symrise Japan Co., Ltd. Sorbitol solution (70%): manufactured by Mitsubishi Corporation Life Sciences Co., Ltd. Propylene glycol: manufactured by ADEKA Corporation Viscosifying silica: manufactured by DSL Japan Co., Ltd., product name: Carplex (registered trademark) #67
Xanthan gum: manufactured by DSP Gokyo Food & Chemical Co., Ltd. Sodium lauryl sulfate: manufactured by BASF Sodium fluoride: manufactured by Stella Chemifa Co., Ltd. Sodium saccharin: manufactured by Aisan Chemical Industry Co., Ltd. Fragrance A to P
The above ingredients were made from raw materials that conformed to the Standards for Quasi-Drug Raw Materials 2006.

The composition of fragrance A used in each example and formulation example, and the compositions of fragrances B to P used in the formulation examples, are shown in Tables 1 to 10 below.

The compositions of flavors 1 to 7 and solvents used in the above fragrances A to P are shown in Tables 3 to 10 below.

Examples 1 to 19 and Comparative Examples 1 to 16
Using the above ingredients as raw materials, oral compositions having the formulations shown in Tables 11 to 14 were prepared according to the preparation methods described below. The amounts of component (A) in Tables 11 to 14 are the pure amounts of extract excluding the extraction solvent.

[Method of preparing oral composition]
The raw materials shown in Tables 11 to 14 were mixed in a conventional manner to obtain oral compositions, which were dentifrices (toothpastes) or mouthwashes. The oral compositions obtained were then placed in any suitable conventional oral preparation container (toothpastes: laminated tubes, mouthwashes: bottles).

The obtained toothpastes (Examples 1 to 18 and Comparative Examples 1 to 16) or mouthwashes (Example 19) were evaluated according to the following procedures. The evaluation results are shown in Tables 11 to 14 below.

[Evaluation method]
1 g of the oral composition according to the Examples and Comparative Examples was placed on the bristles of a toothbrush (Clinica Advantage Toothbrush, 4-row compact normal, manufactured by Lion Corporation), brushed for 3 minutes in the usual manner, and then rinsed the oral cavity once with 10 mL of water to use the oral composition. When the oral composition was a mouthwash, 10 mL of the mouthwash was placed in the oral cavity, rinsed for 30 seconds, and then expelled.

Four subjects scored the stickiness in the mouth after use, the bitterness (aftertaste) derived from the plant extracts after use, and the refreshing feeling in the mouth 60 minutes after use using the following rating scale to calculate an average score, and the average score obtained was rated on a three-level scale of excellent (◎), good (○), or poor (×) according to the following rating scale. The results are shown in Tables 11 to 14 below.

- Evaluation of stickiness in the mouth after use -
(Rating criteria)
5: Not at all noticeable 4: Almost completely noticeable 3: Not much noticeable 2: Slightly noticeable 1: Very noticeable (Evaluation criteria)
◎: 4 points or more ○: 3 points or more but less than 4 points ×: Less than 3 points

- Evaluation of bitterness derived from plant extracts after use -
(Rating criteria)
5: Not at all noticeable 4: Almost completely noticeable 3: Not much noticeable 2: Slightly noticeable 1: Very noticeable (Evaluation criteria)
◎: 4 points or more ○: 3 points or more but less than 4 points ×: Less than 3 points

-Evaluation of oral cavity freshness 60 minutes after use-
(Rating criteria)
5: Very noticeable 4: Slightly noticeable 3: Slightly noticeable 2: Not noticeable at all 1: Not noticeable at all (Evaluation criteria)
◎: 4 points or more ○: 3 points or more but less than 4 points ×: Less than 3 points

The oral compositions of the examples were evaluated for "oral irritation after use" in the same manner as above, based on the following rating scale: No strong irritation was felt in the oral cavity. The results are shown in Tables 11 to 12 below.

- Evaluation of oral irritation after use -
Rating criteria 5: Not felt at all 4: Almost not felt 3: Not felt much 2: Slightly felt 1: Very felt Evaluation criteria ◎: 4 points or more ○: 3 points or more but less than 4 points ×: Less than 3 points

Formulation examples of the oral composition of this embodiment are shown below.
Formulation Example 1: Dentifrice (A1) Rosemary extract 0.0002% by mass
(B) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide
0.001% by mass
(C) Abrasive silica 15% by mass
Sorbitol solution (70%) 30% by weight
Propylene glycol 4% by weight
Viscosifying silica 4% by mass
Xanthan gum 1.5% by mass
Sodium lauryl sulfate 1.5% by weight
Sodium fluoride 0.2% by mass
Sodium saccharin 0.2% by mass
Fragrance (A to P) 1% by mass
Water balance total 100% by mass
(A)/(B)=0.2

Formulation Example 2: Mouthwash (A1): Rosemary extract 0.0002% by mass
(B): N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide
0.005% by mass
Ethanol 2.0% by mass
Citric acid 0.05% by mass
Sodium citrate 0.3% by mass
Polyoxyethylene (60) hydrogenated castor oil 0.5% by mass
Cetylpyridinium chloride 0.05% by mass
Methyl paraoxybenzoate 0.25% by mass
Fragrance (A to P) 1% by mass
Water balance total 100% by mass
(A)/(B)=0.04

Formulation Example 3: Mouthwash (A1): Rosemary extract 0.0002% by mass
(B): N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide
0.005% by mass
Propylene glycol 3.0% by mass
Citric acid 0.05% by mass
Sodium citrate 0.3% by mass
Polyoxyethylene (60) hydrogenated castor oil 0.5% by mass
Cetylpyridinium chloride 0.05% by mass
Methyl paraoxybenzoate 0.25% by mass
Fragrance (A to P) 1% by mass
Water balance total 100% by mass
(A)/(B)=0.04

As is clear from the above, in Comparative Examples 1 to 16, which contain only either component (A) or (B) or component (C), the evaluations of the stickiness in the oral cavity after use, the bitterness derived from the plant extract after use, and the refreshing feeling in the oral cavity 60 minutes after use were all extremely low, whereas in Examples 1 to 19, which may contain both components (A) and (B), as well as component (C), the evaluations of the stickiness in the oral cavity after use, the bitterness derived from the plant extract after use, and the refreshing feeling in the oral cavity 60 minutes after use were all good.

Claims (5)

(A) a plant extract;
(B) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide,
(A) A composition for the oral cavity, wherein the plant extract is an extract of one or more plants selected from the group consisting of rosemary, Scutellaria baicalensis, carrot , licorice, Angelica acutiloba, sword bean, olive, and Phellodendron amplexicaule. (A) containing a plant extract in an amount of 0.00001 to 0.05% by mass in terms of the pure extract content;
The oral composition according to claim 1, further comprising (B) 0.00001 to 0.1 mass% of N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide. The oral composition according to claim 1 or 2, wherein the mass ratio of the content of (A) plant extract (pure extract content) to the content of (B) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide is 0.02 to 100. The oral composition according to any one of claims 1 to 3, which is a dentifrice or mouthwash. The oral composition according to claim 4, which is a dentifrice and further contains 8 to 70 mass % of an abrasive (C).