JP7621741B2 - Eye drop container - Google Patents

Description

The present invention relates to an eye drop container.

Conventionally, containers made of resins such as polyethylene (PE), polypropylene (PP), and polyethylene terephthalate (PET) have been widely used as eye drop containers that contain eye drops. A typical eye drop container has an eye drop container section and a nozzle section that protrudes from the container section, and is configured so that the eye drops can be dispensed from the eye drop container by pointing the nozzle section toward the eye and pressing the container section with the fingers.

On the other hand, in packaging containers such as packaging bags, cyclic olefin resins are known as resins with excellent non-adsorption properties for the contents (see, for example, Patent Documents 1 and 2). In addition, in infusion/medicinal solution bags that contain medicines, etc., it has been proposed to incorporate a light-blocking substance into a specific resin layer of a multi-layered container and further laminate an elution-blocking layer that prevents the elution of the light-blocking substance in order to increase the storage stability of the contents against light (see, for example, Patent Document 3).

International Publication No. 2003/043895 International Publication No. 2004/080370 International Publication No. 2014/189030

To suppress sorption (adsorption or absorption) of the eye drops in the container, it is necessary to use a material that does not easily sorb the active ingredients of the eye drops. Also, to improve the storage stability of the eye drops in the container, it is necessary to give the container a function that blocks external light. Also, in an eye drop container, it is necessary to ensure the visibility of the contents, such as the remaining amount of eye drops. For this reason, if an additive such as a light-blocking substance is added to the resin instead of using an opaque material such as metal foil or a metal vapor deposition layer, it is necessary to prevent the elution of the light-blocking substance.

The present invention was made in consideration of the above circumstances, and aims to provide an eye drop container that suppresses sorption (adsorption, absorption) of eye drops, allows visual confirmation of the contents, has the function of blocking light of a specific wavelength, and can suppress the elution of light blocking substances.

In order to solve the above problem, one aspect of the present invention is an eye drop container having a storage section for storing eye drops, characterized in that the innermost layer of the storage section is composed of a layer containing a cyclic olefin resin, and a light-blocking layer composed of a resin containing at least one light-blocking material selected from the group consisting of ultraviolet absorbers, organic pigments, inorganic pigments, inorganic substances, colored pigments, fluorescent whitening agents, and dyes is laminated on the outer side of the innermost layer of the storage section.

The resin constituting the light blocking layer may be a non-cyclic olefin resin or a cyclic olefin resin.
A non-cyclic olefin resin layer not containing a light blocking material may be laminated on the outer side of the light blocking layer.

The eye drop container may have a nozzle portion for injecting the eye drop contained in the container portion.
The cyclic olefin resin may be at least one type of cyclic olefin copolymer selected from COP (copolymer of different cyclic olefins) and COC (copolymer of cyclic olefin and non-cyclic olefin).

The eye drop container of the present invention suppresses sorption (adsorption, absorption) of eye drops, allows visual confirmation of the contents, and has the function of blocking light of a specific wavelength, thereby suppressing the elution of light blocking substances.

FIG. 2 is a schematic diagram showing an example of an eye drop container. FIG. 2 is a cross-sectional view showing the laminate of the first embodiment. FIG. 6 is a cross-sectional view showing a laminate according to a second embodiment. FIG. 11 is a cross-sectional view showing a laminate according to a third embodiment.

The present invention will be described below based on a preferred embodiment.

Figure 1 is a schematic diagram showing an example of an eye drop container. The eye drop container 10 of this embodiment has a storage section 11 in which liquid eye drops are stored, and a nozzle section 13 for dispensing the eye drops stored in the storage section 11. A stepped diameter-reducing section 12 may be provided between the storage section 11 and the nozzle section 13. The eye drop container 10 may have a cap 14 to protect the nozzle section 13. It is preferable that the cap 14 is connected to at least one of the storage section 11, the diameter-reducing section 12, and the nozzle section 13 in an openable/closable or detachable manner.

The capacity of the storage section 11 is not particularly limited, but may be, for example, 50 ml or less, 1 ml, 2.5 ml, 3 ml, 5 ml, 10 ml, 15 ml, 20 ml, 25 ml, 30 ml, 40 ml, etc., or may be within a range (greater than or equal to A and less than or equal to B) with two numerical values A and B selected from the above numerical group as the lower and upper limits.

Examples of eye drops include aqueous eye drops, oil-based eye drops, eye drops that dissolve when used, and suspension eye drops. Eye drops may contain one or more additives selected from solubilizers, stabilizers, isotonicity agents, buffers, pH regulators, preservatives, thickeners, etc., other than the active ingredient.

Specific examples of active ingredients used in eye drops include, but are not limited to, prostaglandin-related drugs such as isopropyl unoprostone, latanoprost, travoprost, tafluprost, and bimatoprost; nonsteroidal anti-inflammatory drugs such as diclofenac sodium, pranoprofen, bromfenac sodium hydrate, and nepafenac; vitamin B preparations such as cyanocobalamin and flavin adenine dinucleotide sodium; anti-allergic ingredients such as ashitazanolast hydrate, amlexanox, ibudilast, epinastine hydrochloride, olopatadine hydrochloride, sodium cromoglicate, ketotifen fumarate, tranilast, pemirolast potassium, and levocabastine hydrochloride; immunosuppressants such as cyclosporine and tacrolimus hydrate; and beta-blockers such as carteolol. hydrochloride, timolol maleate, nipradilol, betaxolol hydrochloride, levobunolol hydrochloride; α1 blocker, bunazosin hydrochloride; α2 agonist, brimonidine tartrate; parasympathomimetic, pilocarpine hydrochloride; sympathomimetic, dipivefrine hydrochloride; cholinesterase inhibitor, distigmine bromide; cataract treatment drugs, glutathione, pirenoxine; antibacterial drugs, gatifloxacin hydrate, dibekacin sulfate, tosufloxacin tosilate hydrate, tobramycin, vancomycin hydrochloride, moxifloxacin hydrochloride, levofloxacin hydrate, lomefloxacin hydrochloride, ofloxacin, chloramphenicol, norfloxacin; β-blocker/carbonic anhydrase inhibitor combination drugs, dorzolamide hydrochloride, brinzolamide, etc. It may contain one or more of these.

Figure 2 shows the laminate 20 constituting the storage section 11 according to the first embodiment. The laminate 20 of the first embodiment has an innermost layer L1 having an inner surface that can contact the eye drop, a second layer L2 laminated on the outside of the innermost layer L1, and a third layer L3 laminated on the outside of the second layer L2. The innermost layer L1 and the second layer L2 may be in direct contact with each other, or another layer may be interposed between the innermost layer L1 and the second layer L2. The second layer L2 and the third layer L3 may be in direct contact with each other, or another layer may be interposed between the second layer L2 and the third layer L3. The third layer L3 may be the outermost layer of the laminate 20 (a layer in contact with the outside air), or the laminate 20 may have another layer on the outside of the third layer L3. The laminate 20 may have a three-layer structure of the innermost layer L1, the second layer L2, and the third layer L3.

In the laminate 20 of the first embodiment, the innermost layer L1 is composed of a layer 22 containing a cyclic olefin resin. The resin constituting the second layer L2 and the third layer L3 is a non-cyclic olefin resin. The second layer L2 is a light-blocking layer made of a resin containing a light-blocking substance. The innermost layer L1 and the third layer L3 can be resin layers that do not contain a light-blocking substance. That is, the innermost layer L1 is a layer 22 that does not contain a light-blocking substance and contains a cyclic olefin resin, the second layer L2 is a light-blocking layer 21A that contains a non-cyclic olefin resin, and the third layer L3 is a non-cyclic olefin resin layer 21 that does not contain a light-blocking substance.

Figure 3 shows the laminate 20A constituting the storage section 11 according to the second embodiment. The laminate 20A of the second embodiment can be constructed in the same manner as the laminate 20 of the first embodiment, except that the resin constituting the second layer L2 is a cyclic olefin-based resin. That is, the second layer L2 of the laminate 20A is a light blocking layer 22A containing a cyclic olefin-based resin.

Figure 4 shows the laminate 20B constituting the storage section 11 according to the third embodiment. The laminate 20B of the third embodiment has an innermost layer L1 consisting of a layer 22 containing a cyclic olefin resin, and a second layer L2 consisting of a light blocking layer 21A containing a non-cyclic olefin resin. In other words, the laminate 20B of the third embodiment has a configuration in which the third layer L3 is omitted from the laminate 20 of the first embodiment. The laminate 20B may also have a two-layer configuration consisting of the innermost layer L1 and the second layer L2.

When the light blocking layer 21A containing a non-cyclic olefin resin is the outermost layer of the laminate 20B, when the laminate 20B is used as the storage section 11 of the eye drop container 10, a shrink film or the like may be superimposed on the outside of the laminate 20B as a resin layer that is not integrated into the laminate 20B. Also, a non-cyclic olefin resin layer or another resin layer may be superimposed on the outside of the laminate 20B by application, coating, or the like as a resin layer that is integrated into the laminate 20B.

The laminates 20, 20A, and 20B of each embodiment have a layer containing a cyclic olefin resin as a resin with excellent non-sorption (non-adsorption) and moisture resistance. In the laminates 20 and 20B of the first and third embodiments, the innermost layer L1, and in the laminate 20A of the second embodiment, the innermost layer L1 and the second layer L2 contain a cyclic olefin resin. By including at least the innermost layer L1 in a cyclic olefin resin, the non-sorption properties of the contents are improved.

As the cyclic olefin resin, a cyclic olefin copolymer is preferable, and specifically, at least one of so-called COP (copolymer of different cyclic olefins) and COC (copolymer of cyclic olefin and non-cyclic olefin) can be mentioned. Instead of or together with the cyclic olefin copolymer, a cyclic olefin homopolymer or its hydrogenated product can be blended. The layer containing the cyclic olefin resin allows the contents to be sorbed in the storage section 11, and improves moisture resistance through the storage section 11 to suppress evaporation. By suppressing evaporation through the storage section 11, deterioration or change in concentration of the active ingredient due to moisture can be suppressed, and the expiration date of the eye drop can be extended.

The thickness of the layer containing the cyclic olefin resin (total thickness when there are two or more layers) is preferably in the range of 1 to 500 μm, and more preferably in the range of 50 to 200 μm. Specific examples of this thickness include 1 μm, 5 μm, 10 μm, 50 μm, 100 μm, 150 μm, 200 μm, 300 μm, 350 μm, 400 μm, 450 μm, and 500 μm, or a range in which two numerical values A and B selected from the above numerical group are the lower and upper limits (greater than or equal to A and less than or equal to B).

COPs (copolymers of different cyclic olefins) include, for example, copolymers of two or more cyclic olefins, or hydrogenated products thereof. COPs (copolymers of different cyclic olefins) are preferably non-crystalline polymers, and more preferably ring-opening polymers of cyclic olefins produced by metathesis or the like, or hydrogenated products thereof. COPs (copolymers of different cyclic olefins) contain a higher proportion of alicyclic structures than COCs (copolymers of cyclic olefins and non-cyclic olefins), and are excellent in non-sorption (non-adsorption).

COC (copolymer of cyclic olefin and non-cyclic olefin) is, for example, a copolymer of at least one cyclic olefin and at least one non-cyclic olefin, or a hydrogenated product thereof. COC (copolymer of cyclic olefin and non-cyclic olefin) is preferably a non-crystalline polymer, and more preferably a copolymer of cyclic olefin and ethylene, or a hydrogenated product thereof.

The cyclic olefin used as a constituent monomer of the cyclic olefin resin is an unsaturated hydrocarbon (olefin) having at least one ring structure. For example, at least one of vinylcycloalkanes and derivatives thereof having a cycloalkane with 3 to 20 carbon atoms, monocycloalkenes and derivatives thereof having 3 to 20 carbon atoms, and cyclic olefins having a norbornene skeleton (norbornene monomers) can be mentioned.

Examples of norbornene monomers include bicyclo[2.2.1]-2-heptene (norbornene) and its derivatives. Examples of norbornene derivatives include compounds having a substituent such as an alkyl group, compounds having two or more unsaturated bonds such as norbornadiene, and compounds having three or more ring structures, two of which constitute a norbornene skeleton. Examples of norbornene monomers having three or more ring structures include tricyclo[5.2.1.0 ^2,6 ]decene (dihydrodicyclopentadiene), compounds in which one or more molecules of cyclopentadiene are added to norbornene or dihydrodicyclopentadiene by Diels-Alder reaction (e.g., tetracyclododecene, pentacyclopentadecene, hexacycloheptadecene, etc.), hydrogenated products thereof, isomers with different double bond positions, alkyl-substituted products, etc.

Examples of non-cyclic olefins used as constituent monomers for COC (copolymers of cyclic olefins and non-cyclic olefins) include α-olefins such as ethylene, propylene, 1-butene, 1-pentene, 1-hexene, 1-heptene, and 1-octene, and alkenes such as 3-decene and 3-dodecene.

The resin component constituting the layer containing cyclic olefin resin may be at least one type of cyclic olefin resin, or may be a mixture of cyclic olefin resin and other resins. The proportion of cyclic olefin resin in the layer containing cyclic olefin resin is, for example, 50 to 100% by weight. Other resins that can be blended in the layer containing cyclic olefin resin include, for example, non-cyclic olefin resins such as polyethylene resins, and thermoplastic elastomers such as styrene-based elastomers.

The laminates 20, 20A, and 20B that make up the storage section 11 have light-blocking layers 21A and 22A made of resin containing at least one type of light-blocking material. This allows the contents in the storage section 11 to be visually inspected while blocking light of a specific wavelength. Examples of light-blocking materials include light-blocking materials selected from the group consisting of ultraviolet absorbers, organic pigments, inorganic pigments, inorganic substances, colored pigments, fluorescent whitening agents, and dyes.

In the storage section 11, it is preferable that the light transmittance at wavelengths of 380 nm or less is 1% or less. This makes it easier to block near-ultraviolet rays with wavelengths of 200 to 380 nm, which are said to be the most harmful, and has the effect of improving the storage stability of the contents. By setting the light transmittance at wavelengths of 380 nm or more and 400 nm or less to 30% or less, preferably 1% or less, it is possible to block ultraviolet rays close to visible light, and further improve the storage stability of the contents.

In the storage section 11, it is preferable that the light transmittance at a wavelength of 450 nm is 15% or more, and more preferably 55% or more. This makes it easier to visualize the contents from outside the multi-layer laminate, and enables the removal of foreign matter and defects in the visual inspection process, which has the effect of improving quality. It is also preferable to lower the light transmittance at wavelengths of 450 nm or less or 450 nm or more. Blocking of infrared rays may be considered as necessary.

Specific examples of UV absorbers made of organic compounds among light blocking substances include benzophenone compounds, oxybenzone compounds, benzoylmethane compounds, butyl-methoxybenzoylmethane compounds, benzotriazole compounds, triazole compounds, benzoate compounds, hydroxyphenyltriazine compounds, salicylate compounds, triaryltriazine compounds, cinnamic acid compounds, para-aminobenzoic acid compounds, and camphor compounds.

Specific examples of inorganic UV absorbers among light blocking substances include titanium oxide, zinc oxide, iron oxide, cerium oxide, zirconium oxide, nickel oxide, magnesium oxide, mica, kaolin, sericite, etc., or modified versions of these substances.

Specific examples of various pigments consisting of organic pigments, inorganic pigments, and colored pigments among the light blocking substances include organic pigments such as phthalocyanine, and inorganic pigments such as titanium oxide and carbon black. All of these are colored pigments. Colors of colored pigments include yellow, blue, green, orange, red, brown, black, and white. One type of pigment can be used alone, or multiple pigments can be mixed and used.

Specific examples of fluorescent brightening agents or dyes include diaminostilbene compounds, imidazole compounds, thiazole compounds, oxazole compounds, triazole compounds, oxadiazole compounds, thiadiazole compounds, coumarin compounds, naphthalimide compounds, pyrazoline compounds, pyrene compounds, imidazolone compounds, benzidine compounds, diaminocarbazole compounds, oxacyanine compounds, methine compounds, pyridine compounds, anthrapyridazine compounds, distyryl compounds, carbostyryl compounds, indole compounds, and quinolinone compounds.

The proportion of the light-blocking material added to the light-blocking layer is 0.01 to 10% by weight. If the proportion of the light-blocking material added is too small, the light-blocking function will be insufficient, which is undesirable. If the proportion of the light-blocking material added is too high, not only will the cost increase, but there will also be an increased possibility of the light-blocking material leaching out or bleeding out, which is undesirable.

When the resin constituting the light-blocking layer 22A is a cyclic olefin resin, it is preferable because it can suppress the elution and bleeding out of the light-blocking material. Even if the resin constituting the light-blocking layer 21A is a non-cyclic olefin resin, it is possible to suppress the elution and bleeding out of the light-blocking material by laminating a resin layer that does not contain a light-blocking material or a layer that contains a cyclic olefin resin on the inside or outside of the light-blocking layer 21A.

On the outside of the layer containing cyclic olefin resin (second layer L2 or third layer L3), a non-cyclic olefin resin layer 21 that does not contain a light blocking material or a light blocking layer 21A that contains a non-cyclic olefin resin (collectively referred to as a non-cyclic olefin resin layer) is laminated. As a result, when the eye drop container 10 is used, even if the container 11 is touched and pressed, good squeezability is obtained and the function of the eye drop container 10 is less likely to be impaired, compared to when the laminates 20, 20A, 20B that constitute the container 11 are composed only of layers containing cyclic olefin resin.

The thickness of the non-cyclic olefin resin layer (total thickness when both are present) is preferably in the range of 200 to 2000 μm, more preferably in the range of 200 to 1000 μm. Specific examples of this thickness include 200 μm, 300 μm, 350 μm, 400 μm, 450 μm, 500 μm, 600 μm, 700 μm, 800 μm, 900 μm, 1000 μm, 1500 μm, and 2000 μm, or a range with two numerical values A and B selected from the above numerical group as the lower and upper limits (greater than or equal to A and less than or equal to B).

Acyclic olefin resins are polyolefin resins mainly composed of acyclic olefins such as ethylene, propylene, and α-olefins. Examples of acyclic olefin resins include polyethylene resins and polypropylene resins. Examples of polyethylene resins include ethylene homopolymers, linear low-density polyethylene (C4-LLDPE) copolymerized with ethylene and α-olefins with four carbon atoms (1-butene, etc.), linear low-density polyethylene (C6-LLDPE) copolymerized with ethylene and α-olefins with six carbon atoms (1-hexene, etc.), linear low-density polyethylene (C8-LLDPE) copolymerized with ethylene and α-olefins with eight carbon atoms (1-octene, etc.), ethylene-vinyl acetate copolymers (EVA), and ethylene-vinyl alcohol copolymers (EVOH). Examples of polypropylene resins include propylene homopolymers and copolymers of propylene and other olefins.

The resin component constituting the non-cyclic olefin resin layer may be at least one type of polyethylene resin, at least one type of polypropylene resin, or a mixture of polyethylene resin or polypropylene resin with other resins. The non-cyclic olefin resin layer is preferably a polyethylene resin layer mainly composed of polyethylene resin or a polypropylene resin layer mainly composed of polypropylene resin. When two or more non-cyclic olefin resin layers are laminated in the laminate, it is preferable that all of them are polyethylene resin layers or all of them are polypropylene resin layers. The proportion of the main component resin of the non-cyclic olefin resin layer, that is, the polyethylene resin in the polyethylene resin layer and the polypropylene resin in the polypropylene resin layer, is, for example, 50 to 100% by weight. Other resins that can be blended in the non-cyclic olefin resin layer include polypropylene resin in the polyethylene resin layer, polyethylene resin in the polypropylene resin layer, other non-cyclic olefin resins, and thermoplastic elastomers such as styrene-based elastomers.

When the resin component constituting the non-cyclic olefin resin layer is a polyethylene resin, it can be directly laminated to a layer containing a cyclic olefin resin. When the resin component constituting the non-cyclic olefin resin layer is a polypropylene resin, it is preferable to interpose an adhesive layer between the polypropylene resin layer and the layer containing a cyclic olefin resin. Examples of adhesives constituting the adhesive layer include polyester urethane adhesives, polyether urethane adhesives, epoxy adhesives, and acid-modified resins.

When the laminate 20 of the first embodiment has two or more layers of non-cyclic olefin resin layer 21 or light blocking layer 21A containing non-cyclic olefin resin, it is preferable that the thickness of each layer is 10% to 90% of the total of these two or more layers. Also, when the laminate 20A of the second embodiment has two or more layers of cyclic olefin resin-containing layer 22 or light blocking layer 22A containing cyclic olefin resin, it is preferable that the thickness of each layer is 10% to 90% of the total of these two or more layers.

The thickness of the laminates 20, 20A, 20B constituting the storage section 11 is preferably in the range of 300 to 2000 μm, more preferably in the range of 500 to 1500 μm, and may be, for example, 300 μm, 400 μm, 500 μm, 600 μm, 700 μm, 800 μm, 1000 μm, 1200 μm, 1500 μm, 1800 μm, 2000 μm, or a range (greater than A and less than B) with two numerical values A and B selected from the above numerical group as the lower and upper limits. Here, the thickness of the laminates 20, 20A, 20B is the total including the thickness of each layer laminated and molded in close contact with each other over the entire surface of the storage section 11, and does not include the thickness of layers that are partially attached to the storage section such as labels, stickers, etc., or the thickness of layers that are overlapped without being in close contact with each other such as shrink films, etc.

The laminates 20, 20A, 20B constituting the storage section 11 may have one or more of a reinforcing layer, a gas barrier layer, an ultraviolet absorbing layer, and a printed layer. The lamination method for each layer constituting the laminates 20, 20A, 20B may be dry lamination, extrusion lamination, co-extrusion, coating, etc., and may be appropriately selected depending on the material and combination of each layer. The laminates 20, 20A, 20B may be colorless and transparent as a whole, or may be colored partially or entirely in the thickness direction or surface direction. The molding method for the container is not particularly limited, but examples thereof include blow molding. The type of container is not particularly limited, but examples thereof include bottle containers.

The gas barrier layer can be made of, for example, an inorganic material or a gas barrier resin. Examples of inorganic materials include a metal vapor deposition layer and metal oxides such as alumina. Examples of gas barrier resins include ethylene-vinyl alcohol copolymer (EVOH), vinylidene chloride, and fluororesins (PCTFE, PTFE, PFA). However, unlike packaging bags, the storage section of an eye drop container is repeatedly pressed during eye drop administration and is subject to a large load. For this reason, it is preferable that the laminates 20, 20A, and 20B do not include a gas barrier layer made of different materials such as inorganic materials or halogen-containing resins, and that the storage section 11 is made of polyethylene resin and cyclic olefin resin, using a combination that has excellent mutual adhesion.

The storage section 11 may have a layer containing an oxygen absorbent. Examples of oxygen absorbents include conjugated diene polymers and conjugated diene polymer cyclized products obtained by cyclizing the conjugated diene polymers, transition metal salts, and the like. Examples of conjugated diene polymers include polyterpenes such as poly(α-pinene), poly(β-pinene), and poly(dipentene). Examples of transition metal salts include cobalt (II) oleate, cobalt (II) naphthenate, cobalt (II) 2-ethylhexanoate, cobalt (II) stearate, and cobalt (II) neodecanoate. The layer containing the oxygen absorbent may be any of the resin layers of the laminates 20, 20A, and 20B constituting the storage section 11, or may be another layer.

The storage section 11 and the reduced diameter section 12 may be integrally formed from the laminates 20, 20A, and 20B. When the storage section 11 and the reduced diameter section 12 are integrally formed, the nozzle section 13 may have a portion that fits into the reduced diameter section 12. When the storage section 11 and the reduced diameter section 12 are separate bodies, the nozzle section 13 may be integrally formed with the reduced diameter section 12, and the reduced diameter section 12 may have a portion that fits into the upper part of the storage section 11.

In addition to the above-mentioned light-blocking material and oxygen absorber, the laminates 20, 20A, and 20B constituting the storage section 11 can have desired additives added to the resin layer as needed. It is preferable to add these additives to the light-blocking layers 21A and 22A in the same way as the light-blocking material. This makes it possible to suppress the elution or bleeding out of the additives in the same way as the light-blocking material.

The present invention has been described above based on a preferred embodiment, but the present invention is not limited to the above embodiment, and various modifications are possible without departing from the spirit of the present invention.

The packaging container made of the laminate of this embodiment is not limited to the storage section of an eye drop container, but can also be used as a container for storing other contents. Examples include nasal drops, ear drops, and other medicines that are administered by dripping a medicinal liquid onto the affected area.

10...eye drop container, 11...storage section, 12...diameter-reduced section, 13...nozzle section, 14...cap, 20, 20A, 20B...laminated body, 21...non-cyclic olefin resin layer not containing light-blocking material, 21A...light-blocking layer containing non-cyclic olefin resin, 22...layer containing cyclic olefin resin, 22A...light-blocking layer containing cyclic olefin resin, L1...innermost layer, L2...second layer, L3...third layer.

Claims (4)

An eye drop container having a storage section for storing eye drops,
the innermost layer of the housing portion is composed of a layer containing a cyclic olefin resin,
An eye drop container characterized in that a light-blocking layer made of a resin containing a fluorescent brightening agent or a dye is laminated on the outside of the innermost layer of the storage section, and the resin constituting the light-blocking layer is a cyclic olefin-based resin . 2. The eye drop container according to claim 1 , further comprising a non-cyclic olefin resin layer containing no light blocking material laminated on the outer side of the light blocking layer. 3. The eye drop container according to claim 1, further comprising a nozzle portion for injecting the eye drop contained in the container portion. The eye drop container according to any one of claims 1 to 3, characterized in that the cyclic olefin resin is at least one kind of cyclic olefin copolymer selected from COP (copolymer of different cyclic olefins) and COC (copolymer of cyclic olefin and non-cyclic olefin).

Images