JP7790913B2 - Oral composition and method for reducing metallic taste and base odor - Google Patents

Description

The present invention relates to an oral composition containing a polyvalent metal compound and a method for suppressing metallic taste and base odor .

Patent Document 1 describes an oral composition containing a polyvalent metal salt, a surfactant, and a flavoring. It also describes that the composition contains one or more selected from fatty acids and fatty acid esters with a linear structure and carbon atoms of 8 to 22, and fatty acids and fatty acid esters with a branched structure and carbon atoms of 8 to 22. The inclusion of the above fatty acids or fatty acid esters suppresses the metallic taste.

Patent Document 2 describes an oral composition containing a compound that releases metal ions, a surfactant, and a flavoring. It also describes that the composition contains one or more compounds selected from the group consisting of L-menthol derivatives and N-ethyl-p-menthane-3-carboxamide. The inclusion of the above compounds suppresses the metallic taste.

International Publication No. 2018/097122 Japanese Patent Application Laid-Open No. 2003-137755

However, when an oral composition contains a polyvalent metal compound such as a polyvalent metal salt, there is a risk that the fragrance's aroma sensitivity may decrease. A decrease in fragrance sensitivity may also reduce the fragrance's masking effect on the base odor derived from the surfactant. Therefore, in oral compositions containing polyvalent metal compounds, suppressing the metallic taste derived from the polyvalent metal compound as well as the base odor derived from the surfactant is an issue to be addressed.

The oral composition for solving the above problem is an oral composition containing a polyvalent metal compound, a surfactant, and a fragrance, and further containing an ethyl organic acid and damascenone , wherein the ethyl organic acid contains ethyl acetate and ethyl lactate .

In the oral cavity composition, the polyvalent metal compound preferably contains at least one selected from a zinc compound, an iron compound, a copper compound, a tin compound, and an aluminum compound.
A method for solving the above problem is a method for suppressing both the metallic taste derived from the polyvalent metal compound and the base odor derived from the surfactant in an oral composition containing a polyvalent metal compound, a surfactant, and a fragrance, characterized in that the oral composition is formulated in combination with damascenone and an organic ethyl acid containing at least one of ethyl acetate and ethyl lactate.

The oral composition of the present invention can effectively suppress both the metallic taste derived from polyvalent metal compounds and the base odor derived from surfactants.

Hereinafter, one embodiment of the oral cavity composition of the present invention will be described.
The oral composition of the present embodiment contains a polyvalent metal compound, a surfactant, and a flavoring agent, and further contains an organic acid ethyl and damascenone.

By including organic acid ethyl, the metallic taste derived from polyvalent metal compounds can be effectively suppressed. Furthermore, by including damascenone, a decrease in fragrance sensitivity can be prevented. The fragrance's masking effect on the base odor derived from surfactants can be maintained, thereby effectively suppressing the base odor derived from surfactants.

Each component of the oral composition will be described below.
<Polyvalent metal compounds>
The polyvalent metal compound is not particularly limited, and any known polyvalent metal compound used in oral compositions can be used. The polyvalent metal compound preferably has an astringent effect and is used as a medicinal ingredient. Examples of polyvalent metal compounds include zinc compounds, iron compounds, copper compounds, tin compounds, and aluminum compounds, and it is preferable to contain at least one selected from these.

(Zinc compounds)
Specific examples of zinc compounds include zinc chloride, zinc fluoride, zinc fluorosilicate, zinc sulfate, zinc nitrate, zinc hydroxide, zinc oxide, zinc bromate, zinc iodate, zinc fluorophosphate, zinc acetate, zinc formate, zinc benzoate, zinc citrate, zinc tartrate, zinc lactate, zinc malate, zinc mandelate, zinc pyrophosphate, zinc sorbate, zinc pantothenate, zinc gluconate, zinc phytate, zinc glycerophosphate, zinc cinnamate, zinc butyrate, zinc propionate, zinc laurate, zinc stearate, zinc oxalate, zinc salicylate, zinc glycine, zinc aspartate, and zinc glutamate.

(iron compounds)
Specific examples of iron compounds include iron chloride, iron fluoride, iron phosphate, iron fluorosilicate, iron sulfate, iron nitrate, iron hydroxide, iron oxide, iron bromate, iron iodate, iron fluorophosphate, iron acetate, iron formate, iron benzoate, iron citrate, iron tartrate, iron lactate, iron malate, iron mandelate, iron sorbate, iron pantothenate, iron pyrophosphate, iron gluconate, iron phytate, iron glycerophosphate, iron cinnamate, iron butyrate, iron propionate, iron laurate, iron oxalate, iron salicylate, iron glycine, iron aspartate, and iron glutamate.

(copper compound)
Specific examples of copper compounds include copper chloride, copper fluoride, copper fluorosilicate, copper sulfate, copper nitrate, copper hydroxide, copper oxide, copper bromate, copper iodate, copper fluorophosphate, copper acetate, copper formate, copper benzoate, copper citrate, copper tartrate, copper lactate, copper malate, copper mandelate, copper sorbate, copper pyrophosphate, copper pantothenate, copper gluconate, copper phytate, copper glycerophosphate, copper cinnamate, copper butyrate, copper propionate, copper laurate, copper oxalate, copper salicylate, copper glycine, copper aspartate, copper glutamate, and copper chlorophyll.

(tin compounds)
Specific examples of tin compounds include tin chloride, tin fluoride, tin acetate, and tin oxide.

(aluminum compounds)
Specific examples of aluminum compounds include aluminum acetate, aluminum borate, aluminum lactate, aluminum chloride, aluminum hydroxide, aluminum laurate, aluminum oxalate, aluminum oxide, aluminum oleate, aluminum phosphate, and aluminum sulfate.

The above polyvalent metal compounds may be used singly or in combination of two or more.
The content of the polyvalent metal compound in the oral composition is not particularly limited, but is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, and even more preferably 0.5% by mass or more, and is preferably 10% by mass or less, more preferably 5% by mass or less, and even more preferably 3% by mass or less.

<Surfactant>
The surfactant is not particularly limited, and any known surfactant used in oral compositions can be used.

Specific examples of surfactants include nonionic surfactants, anionic surfactants, and amphoteric surfactants.
(Nonionic surfactant)
Specific examples of nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters and maltose fatty acid esters, sugar alcohol fatty acid esters such as maltitol fatty acid esters, sorbitan fatty acid esters such as sorbitan monolaurate, polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monolaurate and polyoxyethylene sorbitan monostearate, fatty acid alkanolamides such as lauric acid diethanolamide, polyoxyethylene alkyl ethers such as polyoxyethylene stearyl ether and polyoxyethylene oleyl ether, polyethylene glycol fatty acid esters such as polyethylene glycol monooleate and polyethylene glycol monolaurate, alkyl glycosides such as lauryl glycoside and decyl glycoside, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene fatty acid esters, alkyl glucosides, polyoxyethylene hydrogenated castor oil, glycerin fatty acid esters, and polyoxyethylene propylene block copolymers.

(anionic surfactant)
Specific examples of anionic surfactants include sulfate ester salts such as sodium lauryl sulfate and polyoxyethylene lauryl ether sodium sulfate, sulfosuccinates such as sodium lauryl sulfosuccinate and polyoxyethylene lauryl ether sodium sulfosuccinate, acylamino acid salts such as sodium cocoyl sarcosine and sodium lauroyl methyl alanine, and sodium cocoyl methyl taurate.

(Amphoteric surfactant)
Specific examples of amphoteric surfactants include amino acid amphoteric surfactants such as N-lauryldiaminoethylglycine and N-myristyldiethylglycine, and betaine amphoteric surfactants such as alkyldimethylaminoacetic acid betaine, N-alkyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine salt, and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine.

The above surfactants may be used alone or in combination of two or more.
The content of the surfactant in the oral composition is not particularly limited, but is preferably 0.1% by mass or more, more preferably 1% by mass or more, and even more preferably 3% by mass or more, and is preferably 20% by mass or less, more preferably 15% by mass or less, and even more preferably 10% by mass or less.

<Fragrance>
The flavoring agent is not particularly limited, and any known flavoring agent used in oral compositions can be used.

The known flavors used in oral compositions may be natural flavors or synthetic flavors, and may be single flavors or blended flavors.
Specific examples of fragrances include menthol, carvone, anethole, eugenol, methyl salicylate, limonene, ocimene, n-decyl alcohol, citronellol, α-terpineol, methyl acetate, citronellyl acetate, methyl eugenol, cineole, linalool, ethyl linalool, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, perilla oil, wintergreen oil, clove oil, eucalyptus oil, pimento oil, d-camphor, d-borneol, fennel oil, cinnamon oil, cinnamon aldehyde, peppermint oil, and vanillin.

The content of flavoring in the oral composition is not particularly limited, but is preferably 0.0001% by mass or more, more preferably 0.001% by mass or more, and even more preferably 0.01% by mass or more. It is also preferably 5% by mass or less, more preferably 2% by mass or less, and even more preferably 1% by mass or less.

<Ethyl organic acid>
The organic acid ethyl ester is not particularly limited.
Specific examples of organic ethyl acids include ethyl formate, ethyl acetate, ethyl propionate, ethyl lactate, ethyl butyrate, ethyl pentanoate, ethyl caproate, ethyl heptanoate, ethyl caprylate, ethyl nonanoate, and ethyl decanoate.

The organic acid ethyl group preferably has 3 or more and 7 or less carbon atoms.
The organic acid ethyl esters may be used alone or in combination of two or more.

The organic ethyl acid preferably contains at least one of ethyl acetate and ethyl lactate, and more preferably contains ethyl acetate and ethyl lactate.
The content of the organic acid ethyl in the oral composition is not particularly limited, but is preferably 0.001% by mass or more, more preferably 0.005% by mass or more, and even more preferably 0.01% by mass or more, and is preferably 1% by mass or less, more preferably 0.5% by mass or less, and even more preferably 0.1% by mass or less.

<Damascenone>
Damascenone is not particularly limited. Damascenone exists as α-, β-, and γ-isomers, and any of these isomers may be used, but the β-isomer is preferred because it can more suitably suppress the decrease in the fragrance acceptance sensitivity of the fragrance.

The amount of damascenone in the oral composition is not particularly limited, but is preferably 0.000001% by mass or more, more preferably 0.000005% by mass or more, and even more preferably 0.00001% by mass or more. It is also preferably 0.01% by mass or less, more preferably 0.005% by mass or less, and even more preferably 0.001% by mass or less.

<Other ingredients>
The oral composition may contain other ingredients besides those mentioned above, such as antibacterial agents, anti-inflammatory agents, humectants, abrasives, alcohols, thickeners, sweeteners, medicinal ingredients, colorants, stabilizers, pH adjusters, etc., depending on the intended application, form, use, etc. These ingredients can be any known ingredients used in oral compositions. These ingredients may be used alone or in combination of two or more. The polyvalent metal compounds exemplified below as other ingredients are also included in the polyvalent metal compounds of the present invention.

Specific examples of antibacterial agents include cetylpyridinium chloride, paraben, sodium benzoate, triclosan, chlorhexidine hydrochloride, isopropylmethylphenol, benzalkonium chloride, benzethonium chloride, and hinokitiol.

Specific examples of anti-inflammatory agents include glycyrrhizinates such as dipotassium glycyrrhizinate, tranexamic acid, ε-aminocaproic acid, and Phellodendron Bark extract.
Specific examples of the humectant include polyhydric alcohols such as sorbitol, glycerin (also called concentrated glycerin), ethylene glycol, propylene glycol, 1,3-butylene glycol, and polyethylene glycol.

Specific examples of abrasives include calcium carbonate, magnesium carbonate, dibasic calcium phosphate, tribasic calcium phosphate, magnesium phosphate, silica, zeolite, sodium metaphosphate, aluminum hydroxide, magnesium hydroxide, calcium pyrophosphate, red iron oxide, calcium sulfate, and silicic anhydride.

Specific examples of alcohols include ethyl alcohol, lauryl alcohol, and myristyl alcohol.
Specific examples of thickeners include sodium polyacrylate, carrageenan, sodium carboxymethylcellulose, sodium alginate, xanthan gum, hydroxyethyl cellulose, hydroxypropylmethyl cellulose, methyl cellulose, and propylene glycol alginate.

Specific examples of sweetening ingredients include saccharin, saccharin sodium, sucralose, stevioside, acesulfame potassium, aspartame, xylitol, maltitol, erythritol, cycloheptaamylose, sorbitol (also known as sorbitol solution), and palatinose (also known as reduced palatinose).

Specific examples of medicinal ingredients include condensed phosphates such as sodium monofluorophosphate, sodium fluoride, sodium pyrophosphate, and sodium polyphosphate, phosphates such as sodium monohydrogen phosphate and trisodium phosphate, vitamins such as ascorbic acid, sodium ascorbate, pyridoxine hydrochloride, and tocopherol acetate, glucanase enzymes such as dextranase and mutanase, proteases, and degradative enzymes such as lysozyme, inorganic salts such as potassium nitrate, chelating compounds such as chlorophyll and glycerophosphate, fat-dissolving polyethylene glycol, and sodium chloride.

Specific examples of colorants include legally designated pigments such as Green No. 1, Blue No. 1, and Yellow No. 4, and titanium oxide.
Specific examples of stabilizers include sodium edetate, sodium thiosulfate, sodium sulfite, calcium lactate, lanolin, triacetin, castor oil, magnesium sulfate, and the like.

Specific examples of pH adjusters include citric acid, malic acid, lactic acid, tartaric acid, acetic acid, phosphoric acid, pyrophosphoric acid, glycerophosphate, and various salts thereof, such as potassium salts, sodium salts, and ammonium salts, as well as sodium hydroxide. It is preferable that the oral composition be formulated with a pH adjuster to adjust the pH to a range of 4 or higher and 9 or lower, particularly 5 or higher and 7 or lower.

<Application form and dosage form of oral composition>
The application form of the oral composition is not particularly limited, and it can be used as, for example, a pharmaceutical, a quasi-drug, or a cosmetic. Known uses of the oral composition can be appropriately adopted, and examples thereof include toothpaste, mouthwash, gargle, liquid dentifrice, biofilm dispersant, agent for preventing bad breath, gum massage agent, oral moisturizer, tongue coating remover, oral application agent, oral disinfectant, throat disinfectant, oral throat agent, periodontal disease treatment agent, denture wearing agent, denture coating agent, denture stabilizer, denture preservative, denture cleaner, and implant care agent.

The dosage form of the oral composition is not particularly limited, and by including a solvent such as water or alcohol, it can be applied as an ointment, paste, spray, gel, liquid, suspension/emulsion, gum, etc.

The type of water used as a solvent is not particularly limited, and examples include distilled water, pure water, ultrapure water, purified water, and tap water. The type of alcohol used as a solvent is not particularly limited, and examples include ethyl alcohol. A mixture of water and alcohol can also be used.

When the oral composition is in a liquid form, the content of a solvent such as water is preferably 20% by mass or more, and more preferably 30% by mass or more.
The action and effect of the oral composition of this embodiment will be described.

(1) An oral composition containing a polyvalent metal compound, a surfactant, and a fragrance, and further containing an organic acid ethyl and damascenone.
By including an organic acid ethyl, the metallic taste derived from polyvalent metal compounds can be suitably suppressed. Furthermore, by including damascenone, a decrease in the fragrance sensitivity of the fragrance can be suppressed. Since the masking effect of the fragrance on the base odor derived from the surfactant can be maintained, the base odor derived from the surfactant can be suitably suppressed. Therefore, both the metallic taste derived from polyvalent metal compounds and the base odor derived from the surfactant can be suitably suppressed. As a result, it is possible to provide an oral composition that is highly palatable and has an excellent feel when used.

(2) The organic ethyl acid has a carbon number of 3 or more and 7 or less. By using an organic ethyl acid with a carbon number of 3 or more and 7 or less, the metallic taste derived from polyvalent metal compounds can be more effectively suppressed.

(3) When the organic ethyl acid contains at least one of ethyl acetate and ethyl lactate, the metallic taste derived from polyvalent metal compounds can be more effectively suppressed. When the organic ethyl acid contains ethyl acetate and ethyl lactate, the metallic taste derived from polyvalent metal compounds can be more effectively suppressed.

The oral cavity composition of the present invention will be described in more detail based on the following test examples. However, the present invention is not limited to the configurations described in the examples.
In the formulation examples shown in Table 1, the types and amounts of (A) polyvalent metal compound, (B) organic acid ethyl, (C) damascenone, and (D) fragrance were changed as shown in Table 2. The oral compositions of Examples 1 to 4 and Comparative Examples 1 to 5 shown in Table 2 were produced by mixing and stirring the components according to a conventional method.

(Evaluation test)
The oral compositions of Examples 1 to 4 and Comparative Examples 1 to 5 were subjected to sensory evaluation for metallic taste, base odor, and fragrance intensity.

(Sensory evaluation of metallic taste, base odor, and aroma intensity)
Sensory evaluation of the metallic taste, base odor, and fragrance intensity was performed by four monitors. First, toothpastes were prepared according to a conventional method using the oral compositions prepared in each Example and Comparative Example. 1 g of this toothpaste was placed on a toothbrush and used to brush teeth. The metallic taste, base odor, and fragrance intensity were then evaluated on a 5-point scale according to the following evaluation criteria. The average scores of the four monitors were calculated, and the results are shown in Table 2.

(Evaluation criteria: metallic taste, base odor)
5 points: Not noticeable 4 points: Slightly noticeable 3 points: Sensible 2 points: Strongly noticeable 1 point: Very strongly noticeable (Evaluation criteria: Fragrance intensity)
5 points: Very strong feeling 4 points: Strong feeling 3 points: Feeling 2 points: Slight feeling 1 point: Not feeling (average score scale)
◎ (Good): 4.5 points or more ○ (Acceptable): 4.0 points or more, less than 4.5 points △ (Unacceptable): 3.0 points or more, less than 4.0 points × (Poor): Less than 3.0 points

As shown in Table 2, Comparative Example 1, which did not contain both (B) organic acid ethyl and (C) damascenone, achieved poor results in the evaluations of metallic taste, base odor, and fragrance intensity. Furthermore, Comparative Examples 2 to 4, which did not contain (C) damascenone, achieved a better metallic taste evaluation than Comparative Example 1, but were unsatisfactory in the evaluations of base odor and fragrance intensity. Comparative Example 5, which did not contain (B) organic acid ethyl, achieved a pass evaluation for base odor and fragrance intensity, but was poor in the evaluation of metallic taste. In contrast, Examples 1 to 4 achieved a pass or better evaluation for metallic taste, base odor, and fragrance intensity. In particular, Examples 3 and 4, which contained both ethyl acetate and ethyl lactate as (B) organic acid ethyl, achieved good evaluations for both metallic taste and base odor.

Claims (3)

An oral composition containing a polyvalent metal compound, a surfactant, and a flavoring agent,
Further, it contains organic acid ethyl and damascenone ,
An oral composition characterized in that the organic acid ethyl comprises ethyl acetate and ethyl lactate . 2. The oral composition according to claim 1 , wherein the polyvalent metal compound contains at least one selected from the group consisting of zinc compounds, iron compounds, copper compounds, tin compounds, and aluminum compounds. A method for suppressing both the metallic taste derived from the polyvalent metal compound and the base odor derived from the surfactant in an oral composition containing a polyvalent metal compound, a surfactant, and a flavor, comprising:
A method characterized by combining an organic ethyl acid containing at least one of ethyl acetate and ethyl lactate with damascenone in the oral composition.