JP7702050B2 - Acidic disinfectant composition and cleaning sheet - Google Patents

Description

The present invention relates to a disinfectant composition and cleaning sheet that have excellent disinfecting properties against bacteria and viruses, antiviral properties, effective oxygen stability, and cleaning properties. Specifically, the present invention relates to a disinfectant composition and cleaning sheet used for sanitary management of equipment and utensils in food factories, kitchens, medical facilities, etc., and more specifically, to an acidic disinfectant composition and cleaning sheet that have excellent disinfecting properties against bacteria and fungi.

Disinfectants are used to reduce the risk of food poisoning and the spread of infection, and to maintain a good sanitary environment in medical facilities, food factories, kitchen facilities, etc. Disinfectants containing quaternary ammonium salts as the main component are generally used for disinfecting medical facilities, food factories, and kitchen facilities. Furthermore, to prevent the proliferation of microorganisms from dirt that adheres to or remains on the disinfected surface, disinfectant compositions that combine nonionic surfactants, anionic surfactants, and amphoteric surfactants to provide cleaning properties are used.

However, disinfectant compositions that contain quaternary ammonium salts as their main component have the problem of causing corrosion and cracking when the surface to be disinfected is made of plastic. In addition, quaternary ammonium salts can cause problems with the emergence of bacteria resistant to cationic surfactants, and residual bacteria can get into food and utensils, causing food spoilage and a deterioration of the sanitary environment.

As for conventional disinfecting cleaning agents, Patent Document 1 describes a wet wiper containing a quaternary ammonium salt. Patent Document 2 describes a wet wiper containing a quaternary ammonium salt, iodide propynyl butylcarbamate, and polyaminopropyl biguanide. Patent Document 3 describes a virucidal composition containing a persulfate, a halide, sulfamic acid, a non-reducing organic acid, and an acidic phosphate.

JP 2016-022272 A JP 2018-188368 A Japanese Unexamined Patent Publication No. 165309/1983

However, although the wet wipers described in Patent Documents 1 and 2 exhibit disinfecting properties against bacteria, mold, etc., when the material of the surface to be disinfected is plastic, they are susceptible to corrosion and cracking, and there is also the concern of the emergence of bacteria resistant to cationic surfactants. The virucidal composition described in Patent Document 3 is generally intended to be in the form of a powder, which requires the time and effort of dissolving the powder before immersing the wet wiper in it. Furthermore, when the composition is made into an aqueous solution, the active ingredient of the persulfate is reduced.

The object of the present invention is therefore to provide an acidic disinfectant composition and cleaning sheet that have excellent disinfecting power with little effect on the material of the surface to be disinfected and no reduction in the active ingredient.

In order to solve the above problems, the inventors conducted extensive research and discovered that an acidic disinfectant composition (wherein the (B) component does not contain sulfuric acid) containing persulfate or a persulfate salt as component (A), an acid agent containing at least one selected from the group consisting of inorganic acids, organic sulfonic acids, and organic phosphonic acids as component (B), a surfactant as component (C), and water as component (D), in which the mass ratio (A)/(C) of component (A) to component (C) is 0.5 or more and 200 or less, and a cleaning sheet having a base sheet impregnated with the composition, can solve the problems that have been conventionally associated with the composition, and have thus completed the present invention.

That is, the present invention is
(1) An acidic disinfectant composition comprising persulfuric acid or a persulfate as a component (A), an acid agent containing at least one selected from the group consisting of an inorganic acid, an organic sulfonic acid, and an organic phosphonic acid as a component (B), a surfactant as a component (C), and water as a component (D), in which the mass ratio (A)/(C) of the component (A) to the component (C) is 0.5 or more and 200 or less (provided that the component (B) does not contain sulfuric acid);
(2) The acidic disinfectant composition according to (1), wherein the component (A) contains potassium hydrogen peroxomonosulfate;
(3) The acidic disinfectant composition according to (1), wherein the component (C) contains at least one selected from the group consisting of amphoteric surfactants and anionic surfactants;
(4) The acidic disinfectant composition according to (3), wherein the component (C) contains at least one selected from the group consisting of alkanesulfonates and polyoxyalkylene alkyl ether sulfates;
(5) The acidic disinfectant composition according to (3), wherein the component (C) is an alkylamine oxide;
(6) The acidic disinfectant composition according to (1), wherein the pH of the acidic disinfectant composition is 0.5 or more and 3 or less;
(7) A cleaning sheet comprising a base sheet impregnated with the acidic disinfectant composition according to any one of (1) to (6).
(8) A cleaning sheet according to (7), wherein the base sheet contains synthetic fibers and is impregnated with 100 parts by mass or more and 600 parts by mass or less of an acidic disinfectant per 100 parts by mass of the fibers constituting the base sheet.

The acidic disinfectant composition and cleaning sheet of the present invention have a low effect on the material of the surface to be disinfected and have an excellent disinfecting effect without any reduction in the active ingredient.

The present invention relates to an acidic disinfectant composition and a cleaning sheet comprising the above-mentioned components (A) to (D) as essential components.
The acidic disinfectant composition and cleaning sheet of the present invention contain persulfuric acid or a persulfate as component (A), which mainly contributes to the disinfecting effect.

As component (A), any persulfate or persulfate salt that has a disinfecting effect can be used. For example, persulfates include sodium peroxodisulfate, potassium peroxodisulfate, ammonium peroxodisulfate, sodium hydrogen peroxomonosulfate, potassium hydrogen peroxomonosulfate, and ammonium hydrogen peroxomonosulfate. For commercial reasons and from the viewpoint of disinfecting properties, potassium hydrogen peroxomonosulfate is preferred as the persulfate. These oxidizing agents may be used alone or in combination.

Incidentally, potassium peroxomonosulfate is contained as part of a triple salt ( _{2KHSO5.KHSO4.K2SO4} ) consisting of potassium peroxomonosulfate, potassium hydrogen _sulfate , and potassium _sulfate , and is commercially available under the trade name "Oxone ^™ ." When component (A) contains potassium peroxomonosulfate, it is preferable that the potassium peroxomonosulfate is derived from a triple salt consisting of potassium peroxomonosulfate, potassium hydrogen sulfate, and potassium sulfate.

The concentration of oxidizing substances such as persulfuric acid can be measured by iodometric titration.
<Test Method>
An appropriate amount of test liquid was weighed out, 10 mL of 20% sulfuric acid and 10 mL of 25% potassium iodide solution were added, and titration was performed with 0.01 mol/L aqueous sodium thiosulfate solution. The point at which the solution became colorless for 30 seconds was set as the endpoint, and the available oxygen concentration was calculated from the amount of 0.01 mol/L aqueous sodium thiosulfate solution dropped up to the endpoint using the following formula (1).
[Calculation formula]
Available oxygen concentration (ppm) = (amount of 0.01 mol/L sodium thiosulfate solution dropped (mL) × 80.00) / amount of test solution (g) (1)

The acidic disinfecting composition of the present invention contains, as component (B), an acid agent containing at least one selected from the group consisting of inorganic acids, organic sulfonic acids, and organic phosphonic acids. This component (B) mainly contributes to the stability of component (A).

Inorganic acids include sulfuric acid, hydrochloric acid, hydrobromic acid, hydroiodic acid, nitric acid, nitrous acid, thiocyanic acid, phosphoric acid, phosphorous acid, hypophosphorous acid, pyrophosphoric acid, tripolyphosphoric acid, tetrapolyphosphoric acid, metaphosphoric acid, pentapolyphosphoric acid, hexametaphosphoric acid, ultraphosphoric acid, and other condensed phosphoric acids.

Examples of organic phosphonic acids include methanesulfonic acid, ethanesulfonic acid, propanesulfonic acid, butanesulfonic acid, hexanesulfonic acid, xylenesulfonic acids such as m-xylenesulfonic acid, toluenesulfonic acids such as p-toluenesulfonic acid, cumenesulfonic acids such as p-cumenesulfonic acid, and benzenesulfonic acids such as methoxybenzenesulfonic acid.

Examples of organic phosphonic acids include 1-hydroxyethylidene-1,1-diphosphonic acid, methylene diphosphonic acid, 1,2-ethylene diphosphonic acid, 1-hydroxypropylidene-1,1-diphosphonic acid, 1-hydroxybutylidene-1,1-diphosphonic acid, and 2-phosphonobutane-1,2,4-tricarboxylic acid.

From the viewpoints of effective oxygen stability, disinfecting properties, and wiping residues after use of the agent, sulfuric acid, hydrochloric acid, nitric acid, phosphoric acid, methanesulfonic acid, pyrophosphoric acid, metaphosphoric acid, m-xylenesulfonic acid, p-toluenesulfonic acid, cumenesulfonic acid, 1-hydroxyethylidene-1,1-diphosphonic acid, and 2-phosphonobutane-1,2,4-tricarboxylic acid are preferred, sulfuric acid, hydrochloric acid, nitric acid, and phosphoric acid are more preferred, and sulfuric acid is even more preferred.

The acidic disinfectant composition of the present invention uses a surfactant as component (C). Any surfactant may be used as long as it provides the effects of the present invention, and examples of such surfactants include amphoteric surfactants, anionic surfactants, cationic surfactants, and nonionic surfactants. In the acidic disinfectant composition of the present invention, amphoteric surfactants, anionic surfactants, and nonionic surfactants are preferred, and amphoteric surfactants and anionic surfactants are more preferred. Component (C) affects cleaning properties, the permeability of the nonwoven fabric to the agent, wiping residues after use of the agent, material effects, etc.

When component (C) is an amphoteric surfactant, examples of the surfactant include alkylaminoacetic acid betaine, alkylamidopropyl betaine, sulfobetaine, alkylamino (mono- or di-)propionate, imidazolinium betaine, alkylamine oxide, alkylaminoethyl glycine, alkyldi(aminoethyl)glycine, glycine n-(3-aminopropyl) C10-16 derivative, alkylpolyaminoethylglycine, alkyl β-alanine, alkyldiethanolamine, polyoxyalkylene alkylamine, diamine oxyethylene adduct surfactant, etc. Among these, alkylamine oxide is preferred, alkyldimethylamine oxide having an alkyl group with 6 to 18 carbon atoms is more preferred, alkyldimethylamine oxide having an alkyl group with 8 to 14 carbon atoms is more preferred, and alkyldimethylamine oxide having an alkyl group with 10 carbon atoms (especially decyl group) is even more preferred. The alkyl group may be branched or straight chain.

When component (C) is an anionic surfactant, examples of the surfactant include fatty acids, alkyl or alkenyl succinic acids, polyoxyalkylene alkyl or alkenyl ether carboxylic acids, alkylol sarcosine, alkyl or alkenyl sulfates, polyoxyalkylene alkyl ether sulfates, polyoxyalkylene alkenyl ether sulfates, amide ether sulfates, alkylbenzene sulfonic acids, olefin sulfonic acids, alkanesulfonic acids, alkyl diphenyl ether disulfonic acids, dialkyl sulfosuccinic acids, polyoxyalkylene alkyl ether sulfosuccinic acid half esters, acyltauric acids, alkyl monophosphates, alkyl triphosphates, polyoxyalkylene alkyl ether phosphates, dipolyoxyalkylene alkyl ether phosphates, tripolyoxyalkylene alkyl ether phosphates, tripolyoxyalkylene alkyl ether phosphates, and alkali metal and ammonium salts thereof. Among these, alkyl sulfates or their salts, polyoxyalkylene alkyl ether sulfates or their salts, and alkanesulfonic acids or their salts are preferred, and secondary alkanesulfonic acids or their salts, and polyoxyethylene alkyl ether sulfates or their salts are more preferred. An example is sodium secondary alkanesulfonate. These may be used alone or in combination of two or more.

The anionic surfactant is a compound in the form of a salt, and may be, for example, an alkali metal salt such as sodium or potassium; an alkaline earth metal salt such as magnesium; or an alkanolamine salt such as monoethanolammonium or diethanolammonium.

The alkyl group of the alkyl sulfate ester salt is preferably an alkyl group having 8 to 18 carbon atoms. Specific examples of the alkyl sulfate ester salt include sodium lauryl sulfate and sodium myristyl sulfate. The alkyl group of the alkyl ether sulfate ester salt is preferably an alkyl group having 10 to 18 carbon atoms. The alkyl ether sulfate ester salt has an oxyethylene group and/or an oxypropylene group, and the average repeat number n of the oxyethylene group is preferably 1 to 5, and the average repeat number m of the oxypropione group is preferably 0 to 1. Examples of the alkyl ether sulfate ester salt include sodium polyoxyethylene lauryl ether sulfate.

It is preferable to use an alkane sulfonate having 14 to 18 carbon atoms, and specific examples include sodium secondary alkane (C14-17) sulfonate and sodium hydroxyalkane (C14-18) sulfonate.

The alkyl group of the linear alkylbenzene sulfonate is preferably an alkyl group having 8 to 16 carbon atoms. Specific examples of linear alkylbenzene sulfonate include sodium laurylbenzene sulfonate and sodium tetradecylbenzene sulfonate.

The alkenyl group of the α-olefin sulfonate is preferably an alkyl group having 8 to 20 carbon atoms. A specific example of the α-olefin sulfonate is Liporan LB-440 manufactured by Lion Corporation.

The alkyl group of the alkyl diphenyl ether sulfonate is preferably an alkyl group having 8 to 18 carbon atoms. Specific examples of alkyl diphenyl ether sulfonate include Pelex SS-H and Pelex SS-L manufactured by Kao Corporation.

The sulfosuccinate is an alkyl succinate having a sulfo group, and the alkyl group preferably has 6 to 18 carbon atoms. Specific examples of the sulfosuccinate include dioctyl sodium sulfosuccinate, didecyl sodium sulfosuccinate, didodecyl sodium sulfosuccinate, and di-2-ethylhexyl sodium sulfosuccinate.

The alkyl group of the alkyl ether carboxylate is preferably an alkyl group having 8 to 18 carbon atoms. The alkyl ether carboxylate also has an oxyethylene group and/or an oxypropylene group, and the average repeat number n of the oxyethylene group is preferably 1 to 10, and the average repeat number m of the oxypropylene group is preferably 0 to 1.

When component (C) is a cationic surfactant, examples of the surfactant include alkyl(alkenyl)trimethylammonium salts, dialkyl(alkenyl)dimethylammonium salts, alkyl(alkenyl)quaternary ammonium salts, mono- or dialkyl(alkenyl)quaternary ammonium salts containing an ether group, an ester group, or an amide group, alkyl(alkenyl)pyridinium salts, alkyl(alkenyl)dimethylbenzylammonium salts, alkyl(alkenyl)isoquinolinium salts, dialkyl(alkenyl)morphonium salts, polyoxyethylene alkyl(alkenyl)amines, alkyl(alkenyl)amine salts, polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride, and benzethonium chloride. Among these, alkyltrimethylammonium salts are preferred.

When component (C) is a nonionic surfactant, examples of the surfactant include polyoxyethylene alkyl ethers, polyoxyethylene alkenyl ethers, polyoxyethylene polyoxypropylene alkyl ethers (the addition form of ethylene oxide and propylene oxide may be either random or block), polyethylene glycol propylene oxide adducts, polypropylene glycol ethylene oxide adducts, glycerin fatty acid esters or their ethylene oxide adducts, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, alkyl polyglucosides, fatty acid monoethanolamides or their ethylene oxide adducts, fatty acid N-methyl monoethanolamides or their ethylene oxide adducts, fatty acid diethanolamides (e.g., coconut oil fatty acid diethanolamide) or their ethylene oxide adducts, sucrose fatty acid esters, alkyl (poly)glycerin ethers, polyglycerin fatty acid esters, polyethylene glycol fatty acid esters, fatty acid methyl ester ethoxylates, etc. Among these, polyoxyethylene alkyl ethers, polyoxyethylene alkenyl ethers, and polyoxyethylene polyoxypropylene alkyl ethers (the addition form of ethylene oxide and propylene oxide may be either random or block) are preferred, and polyoxyethylene alkyl ethers are more preferred.

The alkyl or alkenyl group of the polyoxyethylene alkyl ether, polyoxyethylene alkenyl ether, and polyoxyethylene polyoxypropylene alkyl ether preferably has 8 to 14 carbon atoms. Furthermore, the polyoxyethylene alkyl ether, polyoxyethylene alkenyl ether, and polyoxyethylene polyoxypropylene alkyl ether have an oxyethylene group and/or an oxypropylene group, and the average number of repetitions of the oxyethylene group, n, is preferably 1 to 30, and the average number of repetitions of the oxypropylene group, m, is preferably 0 to 10.

The above components (A) to (C) may each be a single component, or a combination of multiple components.

The acidic disinfectant composition of the present invention contains water as component (D). As the water, tap water, soft water, pure water, RO water, ion-exchanged water, and distilled water can be used. As the tap water, for example, tap water in Arakawa-ku, Tokyo (pH = 7.6, total alkalinity (calcium carbonate equivalent) 40.5 mg/L, German hardness 2.3 ° DH (including calcium hardness 1.7 ° DH and magnesium hardness 0.6 ° DH), chloride ion 21.9 mg/L, sodium and its compounds 15 mg/L, nitrate nitrogen and nitrite nitrogen 1.2 mg/L, fluorine and its compounds 0.1 mg/L, boron and its compounds 0.04 mg/L, total trihalomethane 0.016 mg/L, residual chlorine 0.4 mg/L, organic matter (total organic carbon amount) 0.7 mg/L) can be mentioned.
The water (D) of the present invention constitutes the balance relative to the total amount of the above components (A) to (C), or the balance relative to the total amount of components (A) to (C) and other optional components.

The concentration of the (A) component in the acidic disinfectant composition is not particularly limited as long as the effects of the present invention are achieved. From the viewpoints of disinfecting properties, material effects, and available oxygen stability of the acidic disinfectant composition, the concentration is preferably 0.1 mass % or more and 5 mass % or less, more preferably 0.2 mass % or more and 2 mass % or less, and even more preferably 0.3 mass % or more and 1 mass % or less, based on the total amount of the acidic disinfectant composition.
The potassium hydrogen peroxomonosulfate is contained in a triple salt (2KHSO ₅ ·KHSO ₄ ·K2SO ₄ ) consisting of potassium hydrogen peroxomonosulfate, potassium hydrogen sulfate, and potassium sulfate at 42.8 to about 45% by mass.

The concentration of component (B) in the acidic disinfectant composition is not particularly limited as long as the effects of the present invention are achieved, but from the viewpoint of the disinfecting properties and material effects of the acidic disinfectant composition, it is preferably 0.01% by mass or more and 5% by mass or less, more preferably 0.05% by mass or more and 2% by mass or less, and even more preferably 0.1% by mass or more and 1% by mass or less, based on the total amount of the disinfectant composition.

The concentration of component (C) in the acidic disinfectant composition is not particularly limited as long as the effects of the present invention are achieved, but from the viewpoint of the cleaning properties of the acidic disinfectant composition and the drug penetration into nonwoven fabrics, it is preferably 0.001% by mass or more and 2% by mass or less, more preferably 0.01% by mass or more and 1% by mass or less, and even more preferably 0.02% by mass or more and 0.7% by mass or less, based on the total amount of the acidic disinfectant composition.

The mass ratio of the (A) component to the (C) component in the acidic disinfectant composition of the present invention, (A)/(C), is preferably 0.1 or more and 5000 or less, more preferably 0.2 or more and 1000 or less. It is further preferably 0.5 or more and 300 or less, and most preferably 1 or more and 100 or less. If the (A)/(C) value is less than 0.1, disinfection properties and stability may be insufficient, and if it is more than 5000, cleaning properties and penetration of the agent into the nonwoven fabric may be deteriorated.

The acidic disinfectant composition of the present invention may further contain, as necessary, pH adjusters, glycol solvents and/or glycol ether solvents, chelating agents, dyes, other disinfectants, defoamers, fragrances, corrosion inhibitors, natural extracts, thickeners, enzymes, other salt components (table salt, Glauber's salt, etc.), etc.

Examples of pH adjusters include lithium hydroxide, potassium hydroxide, sodium hydroxide, cerium hydroxide, calcium hydroxide, magnesium hydroxide, barium hydroxide, aluminum hydroxide, sodium carbonate, sodium metasilicate, sodium acetate, potassium phosphate, sodium phosphate, sodium hydrogen phosphate, N,N-dimethylethanolamine, N,N-dibutylethanolamine, N-(β-aminoethyl)ethanolamine, N-methylethanolamine, N-methyldiethanolamine, N-ethylethanolamine, N-ethyldiethanolamine, N-n-butyldiethanolamine, N Examples of such an acid include alkalis such as t-butylethanolamine, N-t-butyldiethanolamine, N-(β-aminoethyl)isopropanolamine, N,N-diethylisopropanolamine, 2-amino-2-hydroxymethyl-1,3-propanediol, aminomethylpropanol, tetrahydroxypropylethylenediamine, morpholine, N-methylmorpholine, N-ethylmorpholine, piperazine, hydroxyethylpiperazine, 2-methylpiperazine, trans-2,5-dimethylpiperazine, and cis-2,6-dimethylpiperazine, and acids other than component (B) (e.g., acetic acid). These may be used alone or in combination of two or more.

Examples of the glycol-based solvents include ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, isoprene glycol, 1,2-butylene glycol, and 1,3-butylene glycol. These may be used alone or in combination of two or more.

Examples of glycol ether-based solvents include ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, ethylene glycol monobutyl ether, ethylene glycol monohexyl ether, ethylene glycol monophenyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, diethylene glycol monobenzyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, triethylene glycol monopropyl ether, triethylene glycol monobutyl ether, triethylene glycol monohexyl ether, triethylene glycol monophenyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, propylene glycol monobutyl ether, dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, dipropylene glycol monopropyl ether, dipropylene glycol monobutyl ether, ethylene glycol dimethyl ether, diethylene glycol dimethyl ether, diethylene glycol methyl ethyl ether, propylene glycol methyl ethyl ether, and dipropylene glycol methyl ethyl ether. These may be used alone or in combination of two or more.

Examples of chelating agents include ethylenediaminetetraacetic acid, nitrilotriacetic acid, methylglycine diacetic acid, hydroxyethylenediaminetriacetic acid, diethylenetriaminopentaacetic acid, triethylenetetraaminehexaacetic acid, hydroxyethyliminodiacetic acid, dihydroxyethylglycine, glutamic acid diacetic acid, aspartic acid diacetic acid, β-alanine diacetic acid, serine diacetic acid, and alkali metal salts thereof. These may be used alone or in combination of two or more.

Examples of the dyes include natural dyes, synthetic dyes, and mixtures thereof. Examples of other disinfectants include sodium hypochlorite, potassium hypochlorite, sodium chlorite, potassium chlorite, sodium chlorate, potassium chlorate, sodium perchlorate, potassium perchlorate, chlorinated sodium isocyanurate, chlorinated potassium isocyanurate, ε-polylysine, poly-γ-glutamic acid, nisin, and the like. Examples of the defoamers include silicone-based defoamers, polyether-based defoamers, and higher alcohol-based defoamers. Examples of the fragrances include natural fragrances, synthetic fragrances, and blends thereof. Examples of the corrosion inhibitors include polycarboxylic acids such as short-chain dicarboxylic or tricarboxylic acids, phosphate esters, triazoles such as benzotriazole, tolyltriazole, and mercaptobenzothiazole, adipic acid, glutaric acid, succinic acid, silicates, and the like. Examples of natural extracts include natural extracts derived from plants such as Cannabaceae, Rubiaceae, Cruciferae, Gramineae, Ebenaceae, Asteraceae, Labiatae, Zingiberaceae, Theaceae, Solanaceae, Cupressaceae, Myrtaceae, Vitaceae, Legumes, Rutaceae, and Liliaceae, as well as natural extracts derived from animals such as lysozyme and milt protein extract. Examples of thickeners include carrageenan, xanthan gum, guar gum, locust bean gum, ghatti gum, karaya gum, and pectin. Examples of enzymes include lipase, alkaline amylase, amylase, cellulase, protease, and pullulanase.

The pH of the acidic disinfectant composition of the present invention is preferably 0.5 or more and 3 or less, more preferably 1 or more and 2.5 or less, from the viewpoint of the stability of component (A).

In the sterilization method using the acidic disinfectant composition of the present invention, the above-mentioned acidic disinfectant composition may be used as a disinfectant liquid by applying it directly to the surface of the object to be disinfected, or the disinfectant liquid may be sprayed or discharged onto the object to be disinfected using a foaming cleaner (spray gun or foam pump) or the like, or the object to be disinfected may be immersed in the disinfectant liquid. Furthermore, the composition may be impregnated into a base sheet described below and used as a cleaning sheet.

(Base sheet)
The cleaning sheet of the present invention includes a base sheet. The cleaning sheet of the present invention may be a single-layer sheet substantially consisting of only the base sheet, or may be a laminated sheet of two or more layers consisting of the base sheet and any sheet laminated thereto. In addition, the cleaning sheet may be laminated with base sheets made of different materials.

The base sheet may be any sheet capable of adequately retaining the impregnated acidic disinfectant composition. Specific examples of the base sheet include nonwoven fabrics, woven fabrics, mesh fabrics, etc. made of recycled fibers, synthetic fibers, natural fibers, or mixtures of these fibers.

From the viewpoint of making the base sheet hydrophilic and enabling an increase in the amount of impregnation of the acidic disinfectant composition, and of exhibiting good virus removal properties, it is preferable that the base sheet is a sheet containing synthetic fibers, and the proportion of synthetic fibers relative to the total mass of the fibers constituting the base sheet is more preferably 10 mass % or more, even more preferably 50 mass % or more, and even more preferably a proportion exceeding 75 mass %.
The amount of the acidic disinfectant composition impregnated into the base sheet can be in the range of 100 parts by mass or more and 600 parts by mass or less, preferably 150 parts by mass or more and 500 parts by mass or less, and more preferably 200 parts by mass or more and 450 parts by mass or less, per 100 parts by mass of the fibers constituting the base sheet.

Regenerated fibers are made by dissolving natural polymer compounds into a solution and then spinning the solution through a spinneret. Examples of natural polymer compounds include cellulose-based materials using cellulose materials such as wood and cotton, and protein-based materials using protein materials such as milk, corn, and peanuts.
Examples of regenerated fibers produced using cellulosic materials include rayon, polynosic, cupra, and lyocell.
Examples of synthetic fibers include polypropylene, polyester, polyethylene terephthalate, polystyrene, and acrylic, and examples of natural fibers include cotton and wool.

The cleaning sheet of the present invention not only exhibits excellent disinfecting properties, but also has excellent corrosion prevention properties for the objects being wiped. Therefore, the present invention is not only used to clean various objects in the home to provide a hygienic environment, but is also useful for disinfecting and wiping in a wide range of fields, including the medical, food, brewing, and agricultural fields. In particular, the present invention achieves both disinfecting properties and the anti-corrosion effect for the objects being wiped, which was previously an issue, and is therefore suitable for maintaining a hygienic environment in the medical and food fields, where there are many opportunities to clean plastic and stainless steel surfaces.

The cleaning sheet of the present invention can be used in a variety of applications, and is suitable for, for example, surface disinfection except for human skin surfaces, equipment disinfection, and bacteria and viruses removal in areas around water such as toilets, around beds, and drains. The cleaning sheet of the present invention can be formed in the form of multiple sheets stacked together, a long sheet wound into a roll, or a sheet folded to an appropriate size.

The present invention will be described in detail below with reference to examples and comparative examples. The components used in the formulations in the examples and comparative examples are shown below. In the following examples, "%" stands for mass % unless otherwise specified, and the numerical values for the formulations in the examples and comparative examples in the tables stand for mass % of the pure content. The "balance" indicating the water content indicates the formulation amount adjusted so that the total amount of the aqueous disinfectant, which is the final preparation, is 100 mass %. The compounds used in the examples and comparative examples are listed below. In addition, when the alkyl group is expressed as alkyl (C8-18), for example, it represents a mixture having an alkyl group with 8 to 18 carbon atoms.

The components of the acidic disinfectant compositions (hereinafter, abbreviated as disinfectant compositions) used in the cleaning sheets of the Examples and Comparative Examples are shown in the following Tables 1 to 9. As for the base sheet, the proportion (mass%) of each constituent fiber relative to 100 mass% of the base sheet is also shown in Tables 1 to 9.
The disinfectant composition was impregnated in an amount of 350 to 450 parts by mass per 100 parts by mass of a nonwoven base sheet containing various fibers in the ratios shown in the table, and the sheet was stored in an airtight container for 24 hours to prepare a cleaning sheet. Each cleaning sheet was clamped in a vice with a force of 10 N cm for 10 minutes, and the solution squeezed out was used as the squeezed liquid.
The cleaning sheet and/or the squeezed liquid were used to carry out the measurements and evaluations described below. The measurement results and evaluation results are shown in Tables 1 to 9.

(A) Component A-1: Potassium peroxysulfate (sulfate) (manufactured by LANXESS, product name "OXONE" (trademark) (double salt consisting of potassium hydrogen peroxymonosulfate, potassium hydrogen sulfate, and potassium sulfate))
A-2: Potassium peroxodisulfate A-3: Sodium peroxodisulfate A-4: Ammonium peroxodisulfate

(B) Components B-1: Sulfuric acid B-2: Hydrochloric acid B-3: Nitric acid B-4: Phosphoric acid B-5: Methanesulfonic acid B-6: Pyrophosphoric acid B-7: Metaphosphoric acid B-8: m-xylenesulfonic acid B-9: p-toluenesulfonic acid B-10: 1-hydroxyethylidene-1,1-diphosphonic acid B-11: 2-phosphonobutane-1,2,4-tricarboxylic acid

(C) Component C-1: Octyldimethylamine oxide (manufactured by Global Amines, product name "GENAMINOX OC (trademark)")
C-2: Decyldimethylamine oxide (manufactured by Global Amines, product name "GENAMINOX K-10 (trademark)")
C-3: Sodium secondary alkane (C14-17) sulfonate (manufactured by Clariant, product name "HOSTAPUR SAS30SB (trademark)")
C-4: Sodium polyoxyethylene alkyl ether sulfate (manufactured by Teika Corporation, product name: Teikapol NE-7030 (trademark))
C-5: Alkyl (C14-C18) trimethylammonium chloride (manufactured by Lion Specialty Chemicals, product name: Lipocard 16-29 (trademark))
C-6: Polyoxyalkylene alkyl (C9-C11) ether (manufactured by Oxalis Chemicals, product name: JCT Ethoxylate 91-6)

(D) Component D-1: Ion-exchanged water

The compositions of each Example were prepared by adding water (D) to a mixing tank so that the total composition was 100% by mass, and then adding components (A), (B), and (C) to the mixing tank and thoroughly mixing and stirring.

Examples 1 to 59, Comparative Examples 1 to 6
The disinfectant compositions shown in Tables 1 to 9 were prepared. Each disinfectant composition was used to measure disinfecting properties, metal and plastic corrosion prevention properties, rinsing properties, and storage stability. Tables 1 to 5 and 7 to 8 show the results of Examples 1 to 59, and Tables 6 and 9 show the results of Comparative Examples 1 to 6, respectively.
It should be noted that Examples 1 to 14, 19, 21 to 31, 35 to 45, 52 to 54, and 56 to 59 are reference examples.

*1: pH measurement method: Connect a composite electrode for pH measurement (HORIBA; glass ground sleeve type) to a pH meter (HORIBA; pH/ion meter F-23) and turn on the power. A saturated potassium chloride solution (3.33 mol/L) was used as the internal solution of the pH electrode.
Next, a 100 mL beaker was filled with a pH 4.01 standard solution (phthalate standard solution), a pH 6.86 standard solution (neutral phosphate standard solution), and a pH 9.18 standard solution (borate standard solution), and the beaker was immersed in a thermostatic bath at 25° C. for 30 minutes. A pH measurement electrode was immersed in the thermostatically adjusted standard solutions for 3 minutes, and calibration operations were performed in the order of pH 6.86 → pH 9.18 → pH 4.01.
Each disinfectant composition was filled into a 100 mL beaker and adjusted to 25° C. in a thermostatic chamber. A pH measurement electrode was immersed in the thermostatically adjusted sample for 3 minutes to measure the pH of the composition.

*2: Evaluation test method for usability:
Ten sheets of each cleaning sheet (200 mm x 250 mm) shown in Tables 1 to 9 were used, and one sheet of nonwoven fabric soaked with the chemical solution was taken out and wiped five times up and down and five times left and right over a clean stainless steel surface of about 30 cm square, and the feeling of use was confirmed by a sensory test in terms of foaming, stickiness, wateriness, stiffness, wetness, etc. Panelists were randomly selected, and n = 10 for each sample. Statistical processing was performed to analyze the evaluation results, and the item with the most evaluations was adopted as the evaluation result.

Evaluation criteria:
○: No foaming, stickiness, wateriness or stiffness, just the right amount of moisture and feels good to use.
△: Slightly foamy, sticky, watery, or stiff, or lacking the appropriate amount of moisture.
×: Very strong foaming, stickiness, wateriness and stiffness, or almost no moisture and poor usability.
The evaluation was made as △ or ◯, and the evaluation was made as practical.

*3: Bacterial sterilization test Staphylococcus aureus (NBRC13276) was used as the test strain.

3-1: Cultivation of strains Test strains were smeared on SCD agar medium (Nissui Pharmaceuticals) and cultivated at 37°C for 24 hours. After that, colonies were scraped off and diluted in sterile phosphate-buffered saline to be used as bacterial suspensions.

3-2: Preparation of sterilized neutralizing solution 10 g of soybean lecithin, 30 g of Tween 80, 1 g of L-histidine, and 20 g of sodium thiosulfate were dissolved in 1 L of distilled water by heating, and cooled while stirring. Then, 9 mL of each solution was dispensed into test tubes with screw caps and sterilized under high pressure (121°C, 20 minutes) to obtain a sterilized neutralizing solution.

3-3: Disinfecting property test Test method:
Each disinfectant composition was diluted to 0.5% by mass with ion-exchanged water to prepare a disinfecting cleaning solution. 0.1 mL of each bacterial suspension was added to the disinfecting cleaning solution to a final concentration of 1.5 to 5.0 x 10 ⁸ (CFU/mL) and the mixture was contacted at 20°C for 1 minute to prepare a test solution. 1 mL of each test solution was added to a sterilized neutralizing solution and thoroughly stirred. The mixed solution was mixed and solidified on SCD agar medium and then cultured at 37°C for 2 days. After the culture, the viable cell count was measured, and the disinfecting ability was evaluated based on the difference from the initial cell count according to the following criteria. Those rated as △, ○, or ◎ were judged to be practical.

Evaluation criteria:
◎: Log reduction of the test bacteria is 6 or more. ○: Log reduction of the test bacteria is 4 or more and less than 6. △: Log reduction of the test bacteria is 2 or more and less than 4. ×: Log reduction of the test bacteria is less than 2.

*4: Bacterial sterilization test (spore-forming bacteria)
Test method:
The test strain was smeared on SCD agar medium (Nissui Pharmaceutical Co., Ltd.) and cultured at 37°C. After the culture, it was confirmed that spores were sufficiently formed by microscopic observation. 10 mL of sterilized pure water was placed on the plate medium, and the colonies were scraped off to collect the suspension. The collected suspension was centrifuged three times at 10,000 rpm, 4°C, and 15 minutes. After centrifugation, an appropriate amount of sterilized pure water was added, and the number of bacteria was adjusted to about 2.0 x 10 ⁸ to 9.0 x 10 ⁸ CFU/mL. The spore-forming bacteria liquid was obtained by heating the mixture in a water bath at 80°C for 15 minutes.

To 10 mL of each squeezed liquid, 0.1 mL of the test spore bacteria liquid was added and allowed to come into contact at 20° C. for 10 minutes, after which a sterilized neutralizing solution was added and thoroughly stirred.
Clostridioides difficile ATCC9689 (10 ⁸ CFU/mL level) was used as the spore-forming bacterium.
1 mL of this solution was mixed and cultured on SCD agar medium to confirm the viable cell count, and the results were evaluated according to the following criteria.

Evaluation criteria:
The reduction in the number of bacteria for each of the above bacterial species was evaluated using a score, with 1 point: a bacterial count reduction of 3 or more for the test bacteria, 2 points: a bacterial count reduction of 2 or more but less than 3, and 3 points: a bacterial count reduction of 2 or less for the test bacteria. The average score for the bacterial count reduction was calculated, and the sterilization ability was evaluated according to the following criteria.
⊚: Average value is 1.0 or more and less than 1.5 points.
○: The average value is 1.5 points or more and less than 2.0 points.
△: Average value is 2.0 points or more and less than 2.5 points.
×: Average value is 2.5 points or more.
The items were judged as practical with △, ○, and ◎.

*5: Virus inactivation test (feline calicivirus)
<Test Method>
A virus test solution (virus test solution 1) was prepared by adding 0.9 mL of each disinfectant composition and 0.1 mL of feline calicivirus solution (FCV F9 strain) adjusted to 10 ⁸ TCID50/mL to a test tube, mixing in a mixer, and allowing to act at 25°C for 1 minute.
In addition, to simulate organic soiling, 0.9 mL of each disinfectant composition and 0.1 mL of feline calicivirus solution (FCV F9 strain) containing 0.5% meat extract (manufactured by Nacalai Tesque) adjusted to ¹⁰ TCID50/mL were added to a test tube to prepare an organic soil-containing virus test solution (virus test solution 2), which was then mixed in a mixer and allowed to act at 25°C for 1 minute.

After reacting for 1 minute as described above, virus test solutions 1 and 2 were diluted 7-fold with Dulbecco's modified Eagle's Medium (DMEM) supplemented with 2% fetal bovine serum (FBS) to stop the reaction. The solution in which the reaction was stopped was serially diluted 7-fold with DMEM medium, and each dilution was inoculated into feline kidney cells (CRFK), which were then cultured in a 1% FBS-supplemented DMEM medium at 37°C in a CO2 incubator for 4 days. After culture, the cytopathic effect was observed, and the virus infectivity (TCID50/mL) was calculated. The virus infectivity log reduction value was calculated from the initial infectivity of the control and the infectivity after the action of the test product, and the virus inactivation effect was evaluated according to the following criteria.

<Evaluation criteria>
⊚: A log reduction of 4 or more in virus infectivity.
○: Log reduction in virus infectivity of 3 or more but less than 4.
Δ: A log reduction in virus infectivity of 2 or more but less than 3.
×: log reduction of virus infectivity of less than 2.
The items were judged as practical with △, ○, and ◎.

*6: Test for reduction of wiping marks caused by cleaning sheets A 15 cm x 15 cm glass plate was prepared, and the surface of the glass plate was wiped five times up and down and five times left and right with each cleaning sheet shown in Tables 1 to 9. The glass plate was then dried at room temperature for two hours, and the remaining wiping marks on the glass plate surface were visually evaluated.

Evaluation criteria:
◎: No noticeable wiping marks.
Good: There is barely any noticeable residue left behind.
△: Wipe marks are slightly noticeable, but not to a problem level.
×: Wipe marks are noticeable.
The items were judged as practical with △, ◯, and ◎.

*7: Evaluation test method for corrosiveness of the object to be wiped:
A total of 18 panels (2 panels each of 9 types of resin and metal panels (vinyl chloride, ABS, polypropylene, polyethylene, acrylic, polycarbonate, silicone, Teflon (registered trademark), and stainless steel) cut to a size of 1 cm x 2.5 cm x 7.5 cm were immersed in 30 mL of each disinfectant composition and stored at 25°C for 48 hours. After that, each panel was rinsed with ion-exchanged water and dried at room temperature for 24 hours, and then the degree of corrosion was evaluated visually.

Evaluation criteria:
◎: No discoloration, deterioration, or cracks are observed on any of the panels.
○: Discoloration, deterioration, cracks, etc. are observed in less than 20% of the panels.
△: Discoloration, deterioration, cracks, etc. are observed in 20% to less than 30% of the panels.
×: Discoloration, deterioration, cracks, etc. are observed in 30% or more of the panels.

*8: Evaluation test method for uneven distribution of drug on base sheet:
Nonwoven fabrics (200 mm × 250 mm × 300 sheets) made of various materials shown in Tables 1 to 9 were placed in a 3 L polypropylene bag, impregnated with 2 L of each disinfectant composition, and stored at room temperature for 24 hours. After that, the bag was cut in half lengthwise and visually observed to see whether the chemical solution had penetrated to the center.

Evaluation criteria:
◎: The drug solution is evenly soaked into the entire surface.
○: The solution is almost entirely saturated.
△: Some areas are not saturated.
×: There are many areas that have not been saturated.
The items were judged as practical with △, ○, and ◎.

*9: Evaluation test method for discoloration of nonwoven fabric:
Ten sheets of each cleaning sheet (200 mm x 250 mm) shown in Tables 1 to 9 were used and stored at 40°C for one week, after which the appearance of the cleaning sheets was visually observed for any change.
Evaluation criteria:
◎: No discoloration or deterioration has occurred.
○: Almost no slight discoloration or deterioration has occurred.
△: Some dark discoloration or severe deterioration has occurred, but not to a problem level.
×: Overall dark discoloration and severe deterioration have occurred.
The items were judged as practical with △, ○, and ◎.

*10: Effective oxygen stability test method:
Nonwoven fabrics (200 mm x 250 mm x 300 sheets) made of PET material shown in Tables 1 to 9 were placed in 3 L bags made of PET and polyethylene with aluminum vapor deposition, impregnated with 2 L of each disinfectant composition, stored at room temperature for 24 hours, and then sealed by heat sealing. The remaining effective oxygen rate after leaving at 40°C for 1 month was measured.
<Test Method>
An appropriate amount of test liquid was weighed out, 10 mL of 20% sulfuric acid and 10 mL of 25% potassium iodide solution were added, and titration was performed with 0.01 mol/L aqueous sodium thiosulfate solution. The point at which the solution became colorless for 30 seconds was set as the endpoint, and the available oxygen concentration was calculated from the amount of 0.01 mol/L aqueous sodium thiosulfate solution dropped up to the endpoint using the following formula (1).
[Calculation formula]
Available oxygen concentration (ppm) = (amount of 0.01 mol/L sodium thiosulfate solution dropped (mL) × 80.00) / amount of test solution (g) (1)

Evaluation criteria:
○: Available oxygen remaining rate is 80% or more △: Available oxygen remaining rate is 60% or more, but less than 80% ×: Available oxygen remaining rate is less than 60%
The evaluation was made as △ or ◯, and the evaluation was made as practical.

*11: Storage stability test method:
100 g of each disinfectant composition was placed in a polypropylene container and allowed to stand at 0° C., 25° C., and 40° C. for one month, after which the appearance was observed.

Evaluation criteria:
○: No separation or turbidity is observed and it is stable. △: No overall separation, some turbidity is observed, but it is not problematic in use. ×: Separation or turbidity is observed.
The evaluation was made as △ or ◯, and the evaluation was made as practical.

Claims (8)

(A) component, persulfuric acid or a persulfate salt;
(B) an acid agent including at least one selected from the group consisting of inorganic acids, organic sulfonic acids, and organic phosphonic acids;
(C) a surfactant as component;
An acidic disinfectant composition comprising water as a component (D), and a mass ratio (A)/(C) of the component (A) to the component (C) being 0.5 or more and 200 or less (provided that the component (B) does not contain sulfuric acid). The acidic disinfectant composition according to claim 1, wherein component (A) contains potassium hydrogen peroxomonosulfate. The acidic disinfectant composition according to claim 1, wherein component (C) contains at least one selected from the group consisting of amphoteric surfactants and anionic surfactants. The acidic disinfectant composition according to claim 3, wherein component (C) contains at least one selected from the group consisting of alkanesulfonates and polyoxyalkylene alkyl ether sulfates. The acidic disinfectant composition according to claim 3, wherein component (C) is an alkylamine oxide. The acidic disinfectant composition according to claim 1, wherein the pH of the acidic disinfectant composition is 0.5 or more and 3 or less. A cleaning sheet comprising a base sheet impregnated with the acidic disinfectant composition according to any one of claims 1 to 6. The cleaning sheet according to claim 7, wherein the base sheet contains synthetic fibers and is impregnated with 100 parts by mass or more and 600 parts by mass or less of an acidic disinfectant per 100 parts by mass of the fibers constituting the base sheet.