JP7803740B2 - Sebum odor suppressant composition - Google Patents

Description

The present invention relates to a sebum odor suppressant composition containing at least one polyhydroxyamine compound selected from the group consisting of trishydroxymethylaminomethane and 2-amino-2-methyl-1,3-propanediol, and sodium lauroamphoacetate.

In recent years, there has been growing awareness of human odors. These odors include body odors that are emitted directly from the human body and odors that are indirectly emitted from clothing, shoes, and other items worn by people. The greasy sweat odor (middle-aged greasy odor) that is characteristic of men aged 30 to 50 has particularly attracted attention as a type of body odor, and it has been revealed that the causative components are diacetyl and short- and medium-chain fatty acids. Among these, short- and medium-chain fatty acids are known to be closely related to sebum odor (an odor derived from sebum, which is generated when sebum adhering to the surface of the skin, body hair, clothing, and the inside of shoes (insoles, etc.) is oxidized by metabolism by resident bacteria, lipid peroxides, oxygen, ultraviolet rays, etc.).

Conventional body odor suppressants have attempted to incorporate antiperspirant or antibacterial ingredients, or to suppress generated body odor by masking with fragrances or removing odorous substances through physical adsorption. Furthermore, deodorizers have been developed to eliminate body odor from a chemical perspective. For example, body odor suppressants containing polyhydroxyamine compounds are known, which neutralize odorous components derived from aldehydes and isovaleric acid, thereby exerting a deodorizing effect from a chemical perspective (Patent Documents 1 to 3).

Japanese Patent Application Laid-Open No. 2006-320711 Japanese Patent Application Laid-Open No. 2007-300963 Japanese Patent Application Laid-Open No. 2015-224244

However, middle-aged oily odor is particularly strong, and even the above-mentioned body odor suppressants are difficult to fully effective, so there is a demand for the development of body odor suppressants with stronger effects.

Therefore, the object of the present invention is to provide a sebum odor suppressant composition that can effectively suppress middle-aged oily odor (especially sebum odor).

In light of the above circumstances, and as a result of extensive research to solve the problem, the inventors discovered that a sebum odor inhibitor composition containing a specific polyhydroxyamine compound and sodium lauroamphoacetate effectively suppresses sebum odor, leading to the completion of the present invention.

That is, the present invention provides a sebum odor inhibitor composition containing at least one polyhydroxyamine compound selected from the group consisting of trishydroxymethylaminomethane and 2-amino-2-methyl-1,3-propanediol (hereinafter sometimes referred to as "component (A)") and sodium lauroamphoacetate (hereinafter sometimes referred to as "component (B)").

The present invention also provides an external skin preparation containing the above-mentioned sebum odor suppressant composition.

The present invention also provides a spray-type deodorant containing the above-mentioned sebum odor suppressant composition.

The present invention also provides a hair cleanser containing the above-mentioned sebum odor suppressant composition.

The sebum odor suppressant composition of the present invention contains the above-mentioned components (A) and (B), and is therefore capable of effectively suppressing middle-aged oily odors (especially sebum odors).

10 shows the deodorizing effect on a used insole according to Example 3. This shows the deodorizing (suppressing) effect on scalp odor of Example 4.

[Sebum odor suppressant composition]
The sebum odor inhibitor composition according to this embodiment is characterized by containing the following components (A) and (B).
Component (A): at least one polyhydroxyamine compound selected from the group consisting of trishydroxymethylaminomethane and 2-amino-2-methyl-1,3-propanediol; and Component (B): sodium lauroamphoacetate.

While the reason why the sebum odor inhibitor composition according to this embodiment is able to effectively suppress middle-aged oily odors (especially sebum odor) is unclear, it is believed to be closely related to the chemical interaction between the above-mentioned components (A) and (B) and the short- and medium-chain fatty acids, which are the causative substances of sebum odor. For example, it is thought that the short- and medium-chain fatty acids, components (A), and (B), respectively, undergo chemical interactions (e.g., chemical reactions, neutralization, etc.), converting the short- and medium-chain fatty acids into substances unrelated to sebum odor. It is also thought that component (B) acts as a catalyst in the chemical interaction between the short- and medium-chain fatty acids and component (A), thereby promoting the conversion of the short- and medium-chain fatty acids into substances unrelated to sebum odor. Through this mechanism, the sebum odor inhibitor composition according to this embodiment, which contains components (A) and (B) simultaneously, exhibits a synergistic deodorizing effect compared to when component (A) or component (B) is used alone.

While short-chain and medium-chain fatty acids are causative substances of sebum odor, medium-chain fatty acids in particular are known to have a significant impact on sebum odor and have attracted attention as a target for deodorization (suppression of sebum odor). The sebum odor inhibitor composition of this embodiment is particularly effective in that it has a significant deodorizing effect on medium-chain fatty acids. Here, it is difficult to uniformly define short-chain and medium-chain fatty acids, but for example, fatty acids with 6 or fewer carbon atoms, such as propionic acid and hexanoic acid, can be defined as short-chain fatty acids, and fatty acids with 7 or more carbon atoms, such as heptanoic acid, octanoic acid, and nonanoic acid, can be defined as medium-chain fatty acids.

The content of component (A) in the sebum odor suppressant composition is not particularly limited, but is preferably 0.001 to 30% by mass, and more preferably 0.1 to 10% by mass. A content of 0.001% by mass or more tends to further improve the sebum odor deodorizing effect. Furthermore, a content of 30% by mass or less is preferred from the standpoint of formulation and stability.

The sebum odor suppressant composition of this embodiment contains sodium lauroamphoacetate. Sodium lauroamphoacetate, when combined with trishydroxymethylaminomethane and/or 2-amino-2-methyl-1,3-propanediol as polyhydroxyamine compounds, significantly enhances the sebum odor suppression effect of the polyhydroxyamine compounds.

The content of component (B) in the sebum odor suppressant composition is not particularly limited, but is preferably 0.00001 to 20% by mass, and more preferably 0.0001 to 10% by mass. A content of 0.00001% by mass or more tends to further improve the sebum odor deodorizing effect. Furthermore, a content of 20% by mass or less is preferred from the standpoint of formulation and stability.

The mass ratio ((A)/(B)) of the content of component (A) to the content of component (B) in the sebum odor inhibitor composition is not particularly limited, but is preferably 0.001 or more, more preferably 0.01 or more, and even more preferably 0.1 or more. It is also preferably 100 or less, and more preferably 50 or less.

The sebum odor inhibitor composition according to this embodiment may contain water or a non-aqueous solvent (hereinafter sometimes referred to as component (C)) as a component other than components (A) and (B).

Examples of water include pure water and ultrapure water such as ion-exchanged water, ultrafiltered water, reverse osmosis water, and distilled water.

Examples of non-aqueous solvents include monohydric alcohols having 2 to 4 carbon atoms, such as ethanol and isopropanol; polyhydric alcohols having 2 to 12 carbon atoms, such as ethylene glycol, propylene glycol, glycerin, and sorbitol; ethers such as monoethyl or monobutyl ethers of ethylene glycol or propylene glycol, and monoethyl or monobutyl ethers of diethylene glycol or dipropylene glycol; aromatic compounds such as benzyl alcohol, benzyloxyethanol, ethylene oxide or propylene oxide adducts of phenolic compounds, and aromatic sulfonates such as p-toluenesulfonate and m-xylenesulfonate; liquefied petroleum gases (LPG) such as propane, propylene, n-butane, and isobutane; liquefied gases such as liquefied carbon dioxide and liquefied nitrogen; compressed gases such as nitrogen, carbon dioxide, air, and nitrous oxide; isopentane, n-pentane, dimethyl ether (DME), and fluorohydrocarbons. Non-aqueous solvents may be used alone or in combination.

Furthermore, when the sebum odor suppressant composition according to this embodiment is used in a spray-type deodorant described below, from the viewpoint of ensuring a suitable spray state, it is preferable that component (C) contains at least one selected from liquefied petroleum gas (LPG), dimethyl ether (DME), isopentane, liquefied gas, and compressed gas.

The content of component (C) in the sebum odor inhibitor composition is not particularly limited, and can be the remainder excluding components (A), (B), and the other components described below. The content of component (C) in the sebum odor inhibitor composition is, for example, preferably 80.0% by mass or more, more preferably 85.0% by mass or more, even more preferably 90.0% by mass or more, and particularly preferably 95% by mass or more. Furthermore, from the perspective of improving the feel during use, the content is preferably 99.9% by mass or less, and more preferably 99.0% by mass or less.

The sebum odor inhibitor composition according to this embodiment may further contain components other than components (A), (B), and (C) (hereinafter referred to as "other components"). The other components are not particularly limited, but examples include disinfectants, antiperspirants, surfactants, thickeners, moisturizers, deodorants, oil components, sequestering agents, preservatives, cooling agents, anti-inflammatory agents, plant extracts, and fragrances.

Bactericides are not particularly limited, but examples include benzalkonium chloride, benzethonium chloride, chlorhexidine hydrochloride, phenol, trichlorocarbanilide, chlorhexidine gluconate, isopropylmethylphenol, triclosan, triclocarban, piroctone olamine, zinc pyrithione, salicylic acid, and sorbic acid, with benzalkonium chloride and isopropylmethylphenol being preferred. Bactericides may be used alone or in combination.

Antiperspirants are not particularly limited, but examples include aluminum salts and zinc paraphenolsulfonate. Examples of aluminum salts include aluminum chloride, aluminum sulfate, aluminum potassium sulfate (potassium alum), aluminum ammonium sulfate (ammonium alum), aluminum acetate, aluminum chlorohydrate, and aluminum allantoin chlorohydrate. Of these, aluminum chlorohydrate, zinc paraphenolsulfonate, and aluminum potassium sulfate are preferred. Antiperspirants may be used alone or in combination.

The surfactant is not particularly limited, but examples include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants. One surfactant may be used alone, or two or more surfactants may be used in combination.

Nonionic surfactants are not particularly limited, but examples include polyoxyethylene alkyl ethers, polyoxyethylene polyoxypropylene alkyl ethers, polyoxyethylene alkylphenyl ethers, polyoxyalkylene castor oil, polyoxyalkylene hydrogenated castor oil, polyoxyalkylene fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyalkylene glycerin fatty acid esters, sorbitan fatty acid esters, polyoxyalkylene sorbitan fatty acid esters, sucrose fatty acid esters, fatty acid alkylolamides, etc. Examples of anionic surfactants include higher fatty acid soaps, alkyl sulfates, alkyl phosphates, polyoxyethylene alkyl ether sulfates, polyoxyethylene alkyl phenyl ether sulfates, alkyl ether phosphates, alkyl ether carboxylates, acyl methyl taurines, N-acyl-N-methyl-β-alanines, N-acyl glycines, N-acyl glutamates, polyoxyethylene alkyl carboxylates, alkyl phenyl ether sulfonates, alkyl sulfosuccinates and salts thereof, N-acyl sarcosines and salts thereof, polyoxyethylene coconut oil fatty acid monoethanolamide sulfates, etc. Examples of cationic surfactants include amine salts such as alkylamine salts, fatty acid amidoamine salts, and ester-containing tertiary amine salts, alkyl quaternary ammonium salts such as monoalkyl quaternary ammonium salts, dialkyl quaternary ammonium salts, trialkyl quaternary ammonium salts, and benzalkonium quaternary ammonium salts, cyclic quaternary ammonium salts such as alkylpyridinium salts, and benzethonium chloride. Examples of amphoteric surfactants include glycine-type amphoteric surfactants such as alkylglycine salts, carboxymethylglycine salts, and N-acylaminoethyl-N-2-hydroxyethylglycine salts; aminopropionic acid-type amphoteric surfactants such as alkylaminopropionates and alkyliminodipropionates; aminoacetic acid betaine-type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine and fatty acid amidopropyldimethylaminoacetic acid betaine; and sulfobetaine-type amphoteric surfactants such as alkylhydroxysulfobetaine.

Thickeners include plant-derived polysaccharide compounds such as guar gum, dextrin, starch, and pectin; animal-derived polysaccharide compounds such as chitosan and hyaluronic acid; microbial-derived polysaccharide compounds such as xanthan gum, cyclodextrin, pullulan, and hyaluronic acid; nonionic celluloses such as methylcellulose, ethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, and hydroxypropylmethylcellulose; anionic celluloses such as carboxymethylcellulose; cationized celluloses such as O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethylcellulose chloride; cationized guar gums such as O-[2-hydroxy-3-(trimethylammonio)propyl]guar gum chloride; carboxyvinyl polymers; and acrylic acid/alkyl methacrylate copolymers. Thickeners may be used alone or in combination of two or more.

Humectants include sorbitol and glycerin. Oil components include hydrocarbons, ester oils, silicones, etc. Cooling agents include menthol such as 1-menthol, menthol derivatives, and camphor, etc.

[External skin preparations]
The topical skin preparation according to this embodiment is characterized by containing the above-mentioned sebum odor suppressant composition.

Topical skin preparations are not particularly limited, but examples include topical skin preparations that impart a cooling sensation to the applied skin, such as refreshing cosmetics; topical skin preparations that impart a moisturizing sensation to the applied skin, such as moisturizing cosmetics; topical skin preparations for antiperspirant use; topical skin preparations for fragrance use; topical skin preparations for disinfection; topical skin preparations for cleansing use, etc. Topical skin preparations may also be, for example, cosmetics, quasi-drugs, pharmaceuticals, or miscellaneous goods.

The topical cleansing skin preparation is not particularly limited, but examples include hair cleansers such as shampoos and conditioners, body cleansers such as body soaps, and face cleansers such as cleansers and facial washes. Of these, hair cleansers and body cleansers are preferred, as they contain a sebum odor suppressant composition that can effectively suppress middle-aged oily odors (especially sebum odor), with hair cleansers being more preferred.

Topical skin preparations can be used in a variety of forms, including lotions, aerosols, non-aerosol sprays, sticks, roll-ons, creams, gels, emulsions, and sheet cosmetics, and can be formulated using commonly known methods. For example, the above components can be mixed and stirred using a known stirring device such as a disper mixer or paddle mixer to homogenize the components.

A sheet cosmetic is obtained by impregnating a sheet substrate with a topical skin preparation. This results in excellent usability for wiping the skin and excellent portability. The planar shape of the sheet is not particularly limited, but examples include polygons such as quadrilaterals (e.g., squares, rectangles, etc.), triangles, circles, ellipses, semicircles, crescents, barrels, drums, and character shapes, with quadrilaterals being preferred from the standpoints of productivity, usability, and packability. The sheet cosmetic may also be molded with slits, cutouts, irregularities, etc. The surface area of one side of the sheet of the sheet cosmetic is not particularly limited, but is preferably 100 to 500 ^cm2 from the standpoints of usability, portability, packability, etc.

The sheet cosmetic can be produced by impregnating a sheet substrate with the topical skin preparation according to this embodiment. The method for impregnating the sheet substrate with the topical skin preparation is not particularly limited, and examples include a method in which the topical skin preparation is injected into a folded sheet substrate to impregnate it, a method in which the topical skin preparation is sprayed onto the sheet substrate, a method in which the topical skin preparation is impregnated into the sheet substrate using a printing method, and a method in which the sheet substrate is immersed in the topical skin preparation.

The material of the sheet substrate is not particularly limited as long as it can be impregnated with the topical skin preparation, and any sheet substrate commonly used in cosmetics can be used as appropriate. Examples of sheet substrate materials include woven or nonwoven fabrics made from natural, synthetic, or semi-natural fibers. From the perspective of improving impregnation and usability, nonwoven fabrics are preferred.

Natural fibers include cotton, pulp, silk, cellulose, hemp, linter, and kabab. Synthetic fibers include nylon, polyester fiber, polyacrylic fiber, polypropylene fiber, polyethylene fiber, and polyethylene terephthalate fiber. Semi-natural fibers include rayon and acetate. The above fibers may be used alone or in combination of two or more.

The surface of the sheet substrate may be embossed. Sheet substrates also include film substrates.

The mass ratio of the topical skin preparation according to this embodiment impregnated into the sheet substrate in the sheet cosmetic is not particularly limited, but from the standpoint of usability, it is preferably 100 parts by mass or more, and more preferably 250 parts by mass or more, per 100 parts by mass of the sheet substrate. Furthermore, from the standpoint of usability, it is preferably 600 parts by mass or less, and more preferably 500 parts by mass or less.

It is preferable that sheet cosmetics be stored in a packaging container from the standpoints of preventing drying, portability when out and about, and ease of handling during use. Sheet cosmetics may be individually wrapped, or from the standpoints of production cost, production efficiency, and the like, multiple sheets of sheet cosmetics may be stored in the same packaging container. There are no particular restrictions on the number of sheet cosmetics stored in one packaging container, but 2 to 50 sheets (per packaging container) are preferred. In particular, since there is little difference in feel between the top and bottom sheets when using multiple sheets of sheet cosmetics stacked and stored, 10 sheets or more (per packaging container) may be used. It is preferable that sheet cosmetics be stored folded in half, in thirds, in quarters, cross-folded in quarters, etc. in the packaging container.

Examples of packaging containers include bags (packaging bags) and box-shaped containers. Packaging containers that can suppress the evaporation of the topical skin preparation according to this embodiment are preferred. The material of the packaging container is not particularly limited, but examples include resins such as polyethylene terephthalate (PET), polyethylene (PE), and polypropylene (PP); and metals such as aluminum. From the viewpoints of lightweight packaging containers and excellent evaporation prevention effects, packaging containers (particularly packaging bags) made of resin with a metal layer laminated or vapor-deposited on the surface are preferred, and packaging bags made of resin with aluminum vapor-deposited on the surface are more preferred.

The topical skin preparation according to this embodiment is used by applying it to the skin. The application areas of the topical skin preparation are not particularly limited, but include, for example, the face (e.g., forehead, cheeks, mouth, etc.), chest, back, arms, elbows, backs of the hands, fingertips, feet, knees, heels, neck, armpits, and other body parts, as well as the head (scalp). The sheet cosmetic according to this embodiment can also be applied to the same areas as the topical skin preparation.

[Spray-type deodorant]
The spray-type deodorant according to this embodiment is a spray-type deodorant containing the above-mentioned sebum odor inhibitor composition. The spray formulation is not particularly limited, and examples include non-aerosol sprays such as mist sprays, and aerosol sprays. The spray-type deodorant according to this embodiment is equipped with a spray container and a spray nozzle, and the above-mentioned sebum odor inhibitor composition is filled in the spray container. Alternatively, the spray container may be an aerosol spray-type deodorant in which a propellant is further filled in addition to the above-mentioned sebum odor inhibitor composition. Furthermore, the spray-type deodorant may be a non-aerosol spray-type deodorant in which the spray nozzle is a pump-type spray nozzle. The spray-type deodorant is preferably a spray-type deodorant in which the above-mentioned sebum odor inhibitor composition is sprayed in the form of a mist.

Propellant examples include liquefied petroleum gas (LPG), dimethyl ether (DME), diethyl ether, isobutane, isopentane, liquefied gas, and compressed gas. A single propellant may be used, or two or more may be used in combination. From the perspective of preventing clogging, it is preferable for the propellant to contain at least one of liquefied petroleum gas and dimethyl ether, and it is more preferable for the propellant to contain liquefied petroleum gas.

Of the total of the sebum odor inhibitor composition and propellant (100% by mass), the content of the sebum odor inhibitor composition is preferably 10.0% by mass or more, more preferably 20.0% by mass or more, preferably 70.0% by mass or less, more preferably 60.0% by mass or less, and even more preferably 50.0% by mass or less. When the content of the sebum odor inhibitor composition is above the above lower limit and below the above upper limit, ejection properties are even better.

Of the total 100% by mass of the sebum odor suppressant composition and propellant, the propellant content is preferably 30.0% by mass or more, more preferably 40.0% by mass or more, even more preferably 50.0% by mass or more, preferably 90.0% by mass or less, and more preferably 80.0% by mass or less. When the propellant content is above the above lower limit and below the above upper limit, ejection properties are even better.

The application areas of the spray-type deodorant according to this embodiment are not particularly limited, but examples include skin, hair, clothing, and footwear. Examples of skin include the face (e.g., forehead, cheeks, mouth, etc.), chest, back, arms, elbows, backs of the hands, fingertips, feet, knees, heels, neck, and armpits, as well as the head (scalp). Examples of clothing include jackets, dress shirts, coats, T-shirts, sweatshirts, sweaters, jerseys, pants, slacks, jeans, skirts, dresses, underwear, pajamas, yukata, hats, scarves, bandanas, mufflers, neckties, obi belts, belts, socks, leg warmers, and tights. It is preferable to apply the spray-type deodorant to areas that frequently come into direct contact with the skin and are susceptible to sebum odor, such as the cuffs, collars, and inside of underwear and socks. Examples of footwear include shoes, sneakers, high heels, pumps, mules, boots, and insoles. It is preferable to apply the spray-type deodorant to areas susceptible to sebum odor, such as insoles.

[Hair cleanser]
The hair cleanser according to this embodiment is a hair cleanser containing the sebum odor inhibitor composition. Examples of the hair cleanser include hair shampoo, hair rinse, hair conditioner, hair treatment, and rinse-in shampoo.

The content of component (A) in the hair cleanser is not particularly limited, but is preferably 0.001 to 30% by mass, more preferably 0.1 to 10% by mass, and even more preferably 0.2 to 4% by mass. The content of component (B) in the hair cleanser is not particularly limited, but is preferably 0.00001 to 20% by mass, more preferably 0.01 to 10% by mass, and even more preferably 0.1 to 6% by mass.

When the hair cleanser according to this embodiment is a hair shampoo, it preferably contains at least one surfactant selected from the group consisting of the nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants, in order to enhance cleansing properties. The surfactant content is not particularly limited, but is preferably 0.1 to 30.0% by mass.

When the hair cleanser according to this embodiment is a hair shampoo, it preferably contains water. The amount of water contained is not particularly limited and can be adjusted appropriately depending on the purpose of use. The water exemplified above as component (C) can be used.

The hair cleanser according to this embodiment may contain any ingredients selected appropriately, provided that the effects of the cleanser are not impaired. Examples of such optional ingredients include moisturizers, penetration enhancers, hair conditioning agents, pH adjusters, thickeners, viscosity adjusters, antistatic agents, chelating agents, preservatives, antioxidants, cooling agents, antibacterial agents, emulsifiers, emulsion stabilizers, herbal medicines, vitamins, proteins, fragrances, higher alcohols, silicones, oil components, and pigments.

The present invention will be explained in more detail below based on examples, but the present invention is not limited to these examples.

[Example 1-1]
20 μl of a model sebum odor (a mixture containing propionic acid, hexanoic acid, heptanoic acid, octanoic acid, and nonanoic acid) was mixed with 300 μl of an aqueous solution containing 0.1% by mass of trishydroxymethylaminomethane and 0.054% by mass of sodium lauroamphoacetate as a sebum odor inhibitor composition, and the mixture was impregnated into a 1.5 cm cotton pad. This cotton pad was placed in a 40 mL vial, the lid was closed, and the pad was allowed to stand at 37°C for 30 minutes. After standing, the headspace gas in the vial was collected using a fiber optic cable for solid-phase microextraction (SPME) and analyzed by GC-MS under the following conditions to measure the content of each fatty acid contained in the model sebum odor.
[Analysis conditions]
Column used: Agilent Technology, product name: DB-FFAP (60 m x 0.25 mm x 0.5 μm)
Gas used: Helium Temperature conditions: 40°C (maintained for 3 minutes), temperature increase from 40°C to 140°C (heating rate 7°C/min), temperature increase from 140°C to 220°C (heating rate 15°C/min) (maintained for 13 minutes), ionization method: electron ionization (EI), 60 eV

The same procedure was carried out except that the sebum odor inhibitor composition was not used, and the content of each fatty acid contained in the model sebum odor was measured. Using this as a blank, the adsorption rate when the sebum odor inhibitor composition was used was calculated using the following method. This is referred to as the "adsorption rate of odorous substances by the sebum odor inhibitor composition containing components (A) and (B)."
Adsorption rate (of each fatty acid) [%] = (content of each fatty acid in blank - content of each fatty acid when sebum odor inhibitor composition is used) / content of each fatty acid in blank x 100

20 μl of the model sebum odor was mixed with 300 μl of an aqueous solution containing 0.1% by mass of trishydroxymethylaminomethane as a sebum odor inhibitor composition, and the mixture was soaked into a 1.5 cm cotton pad. This cotton pad was placed in a 40 mL vial, the lid was closed, and the pad was left to stand at 37°C for 30 minutes. After standing, the headspace gas in the vial was collected using a fiber for solid-phase microextraction (SPME) and analyzed by GC-MS to measure the content of each fatty acid contained in the model sebum odor. The adsorption rate was calculated in the same manner as above. This is referred to as the "adsorption rate of odorous substances by a sebum odor inhibitor composition containing only component (A)."

20 μl of the model sebum odor was mixed with 300 μl of an aqueous solution containing sodium lauroamphoacetate at a concentration of 0.054% by mass as a sebum odor inhibitor composition, and the mixture was soaked into a 1.5 cm cotton pad. This cotton pad was placed in a 40 mL vial, the lid was closed, and the pad was left to stand at 37°C for 30 minutes. After standing, the headspace gas in the vial was collected using a fiber for solid-phase microextraction (SPME) and analyzed by GC-MS to measure the content of each fatty acid contained in the model sebum odor. The adsorption rate was calculated in the same manner as above. This is referred to as the "adsorption rate of odorous substances by a sebum odor inhibitor composition containing only component (B)."

Based on the above results, the "adsorption rate of odorous substances by a sebum odor inhibitor composition containing components (A) and (B)" / ("adsorption rate of odorous substances by a sebum odor inhibitor composition containing only component (A)" + "adsorption rate of odorous substances by a sebum odor inhibitor composition containing only component (B)") (hereinafter referred to as "Fold") was calculated. When the Fold value is 1.0 or greater, the adsorption rate when a sebum odor inhibitor composition containing components (A) and (B) is used is greater than the sum of the adsorption rates when a sebum odor inhibitor composition containing either component (A) or (B) alone is used. Therefore, the sebum odor inhibitor composition containing components (A) and (B) simultaneously exhibits a synergistic deodorizing effect.

[Examples 1-2 to 1-5, Comparative Examples 1-1 to 1-3]
GC-MS analysis, calculation of adsorption rate, and calculation of Fold were carried out in the same manner except that the sebum odor inhibitor composition was replaced with that shown in Table 1, and the results are shown in Table 1. The abbreviations in Table 1 are explained below.
TAM: Trishydroxymethylaminomethane AMP: 2-amino-2-methyl-1-propanol AMPD: 2-amino-2-methyl-1,3-propanediol LAA: Sodium lauroamphoacetate CAA: Sodium cocoamphoacetate LAP: Sodium lauraminopropionate

As can be seen from Table 1, the sebum odor inhibitor composition containing trishydroxymethylaminomethane and sodium lauroamphoacetate has higher Folds than the sebum odor inhibitor composition containing these components alone, demonstrating a synergistic deodorizing effect (Comparison between Example 1-1 and Comparative Example 1-1). In particular, a high effect is demonstrated for medium-chain fatty acids (heptanoic acid, octanoic acid, nonanoic acid), which have a significant impact on the "smell" of sebum odor. Furthermore, the sebum odor inhibitor composition containing 2-amino-2-methyl-1,3-propanediol and sodium lauroamphoacetate has a higher Fold for the medium-chain fatty acid heptanoic acid than the sebum odor inhibitor composition containing these components alone, demonstrating a synergistic deodorizing effect and demonstrating a remarkable effect (Comparison between Example 1-3 and Comparative Example 1-1).

[Example 2]
20 μL of model sebum odor and 300 μL of three kinds of aqueous solutions as sebum odor inhibitor compositions, (1) an aqueous solution of trishydroxymethylaminomethane concentration of 0.15 mass%, (2) an aqueous solution of sodium lauroamphoacetate concentration of 0.15 mass%, (3) an aqueous solution of trishydroxymethylaminomethane concentration of 0.1 mass% and sodium lauroamphoacetate concentration of 0.05 mass%, were mixed and soaked into a cotton pad of 1.5 cm on a side. This cotton pad was placed in a 40 mL vial, the lid was closed, and it was left to stand at 37 ° C for 30 minutes, and the odor intensity was evaluated according to the following criteria. Note that, as a control, one that did not use the above-mentioned sebum odor inhibitor composition was used.

The odor intensity (odor intensity) was evaluated by a sensory evaluation in which three evaluators (referred to as evaluators 1 to 3 in the table) opened the vials after standing in a room at 25°C and smelled the odor. The evaluation was based on the following criteria, and the average score of the three evaluators was calculated. The results are shown in Table 2.
(Odor Intensity)
5.0 points: Very strong odor 4.5 points: Between 4.0 and 5.0 points 4.0 points: Slightly strong odor 3.5 points: Between 3.0 and 4.0 points 3.0 points: Clear odor 2.5 points: Between 2.0 and 3.0 points 2.0 points: Weak odor 1.5 points: Between 1.0 and 2.0 points 1.0 points: Slight odor 0.5 points: Between 0 and 1.0 points 0 points: No odor

Table 2 reveals that samples containing trishydroxymethylaminomethane and sodium lauroamphoacetate (hereinafter sometimes referred to as "mixed samples") have a stronger deodorizing effect than samples containing either of these compounds alone (hereinafter sometimes referred to as "single samples").

In this sensory evaluation, a reduction in odor intensity (score) indicates a significant deodorizing effect, and whether or not it exceeds 3.0 points ("clear odor") is an important factor in determining whether or not a deodorizing effect is present. The mixed sample is able to deodorize the model sebum odor to the point where it is no longer clearly detectable. On the other hand, the single sample was less able to deodorize than the mixed sample, and its deodorizing effect was extremely low compared to the control. In other words, while the single sample showed almost no deodorizing effect, the mixed sample showed an extremely high deodorizing effect. In this way, the difference in odor intensity between the mixed sample and the single sample can be said to indicate the significant deodorizing effect of using the mixed sample. In other words, it can be seen from Table 2 that the inclusion of both trishydroxymethylaminomethane and sodium lauroamphoacetate produces a synergistic deodorizing effect.

[Example 3]
As samples for evaluating the deodorizing effect, an aqueous solution containing 10% by mass of trishydroxymethylaminomethane, an aqueous solution containing 0.27% by mass of sodium lauroamphoacetate, and an aqueous solution containing 10% by mass of trishydroxymethylaminomethane and 0.27% by mass of sodium lauroamphoacetate were prepared. The pH of each of these solutions was 6.0.

Subjects were asked to use new, sterilized shoe insoles for 30 consecutive days, and the odor intensity of the used insoles was evaluated (1) before spraying with the sample, (2) 3 minutes after spraying with the sample, and (3) 30 minutes after spraying with the sample.

The odor intensity was evaluated by a sensory evaluation in which three evaluators smelled each insole after continuous use in a room at 25°C. The evaluation was based on the following criteria, and the average score of the three evaluators was calculated. The results are shown in Figure 1.
(Odor Intensity)
5.0 points: Very strong odor 4.5 points: Between 4.0 and 5.0 points 4.0 points: Slightly strong odor 3.5 points: Between 3.0 and 4.0 points 3.0 points: Clear odor 2.5 points: Between 2.0 and 3.0 points 2.0 points: Weak odor 1.5 points: Between 1.0 and 2.0 points 1.0 points: Slight odor 0.5 points: Between 0 and 1.0 points 0 points: No odor

Figure 1 clearly shows that, at both "3 minutes after spraying" and "30 minutes after spraying," the sample containing trishydroxymethylaminomethane and sodium lauroamphoacetate (hereinafter sometimes referred to as the "mixed sample") had a greater deodorizing effect than the sample containing either of these compounds alone (hereinafter sometimes referred to as the "single sample").

In this sensory evaluation, a reduction in odor intensity (score) indicates a significant deodorizing effect, and whether or not the odor intensity exceeds 3.0 points ("clear odor") is an important factor in determining whether or not a deodorizing effect is present. Based on the results "30 minutes after spraying," when the mixed sample was used, the odor intensity was lower than "weak odor" and approached "faint odor." In other words, the mixed sample was able to deodorize the insole to the point where the odor was no longer clearly detectable. On the other hand, the single sample was less able to deodorize than the mixed sample. In this way, the difference in odor intensity between the mixed sample and the single sample can be said to indicate the significant deodorizing effect of using the mixed sample. In other words, it can be seen from Figure 1 that the inclusion of both trishydroxymethylaminomethane and sodium lauroamphoacetate provides a synergistic deodorizing effect.

[Example 4]
A comparative product is prepared according to the same formula as Lucido Scalp Deo Shampoo (manufactured by Mandom Corporation).Except that the concentration of trishydroxymethylaminomethane is 0.5% by mass and the concentration of sodium lauroamphoacetate is 0.3% by mass, the same formula as Lucido Scalp Deo Shampoo is prepared, test product A is prepared.Except that the concentration of trishydroxymethylaminomethane is 1.0% by mass and the concentration of sodium lauroamphoacetate is 0.6% by mass, the same formula as Lucido Scalp Deo Shampoo is prepared, test product B is prepared.9 subjects (9 subjects x 3 groups, total 27 subjects) of the comparative product and test products A and B are used for 2 weeks consecutively.

After two weeks of continuous use, the scalp odor was evaluated approximately 24 hours after the last use (hereinafter referred to as "scalp odor before washing"). Thereafter, the hair was washed with the comparison product, test product A, or test product B that had been used continuously for the above two weeks, and the scalp odor immediately after washing (hereinafter referred to as "scalp odor after washing") was evaluated. The scalp odor evaluation was carried out by a panel of three experts. The average scores for the scalp odor before washing and the scalp odor after washing for each subject group were calculated, and the odor intensity was evaluated based on the difference between the average scores ("average score for scalp odor after washing" - "average score for scalp odor before washing"). The evaluation was carried out based on the following criteria. The results are shown in Figure 2.
(Odor Intensity)
5.0 points: Very strong odor 4.5 points: Between 4.0 and 5.0 points 4.0 points: Slightly strong odor 3.5 points: Between 3.0 and 4.0 points 3.0 points: Clear odor 2.5 points: Between 2.0 and 3.0 points 2.0 points: Weak odor 1.5 points: Between 1.0 and 2.0 points 1.0 points: Slight odor 0.5 points: Between 0 and 1.0 points 0 points: No odor

The change in scalp odor intensity ("average scalp odor score after washing" - "average scalp odor score before washing") was -0.37 points for the comparison product, -0.57 points for test product A, and -0.69 points for test product B (Figure 2). This demonstrates that the sebum odor inhibitor composition of the present invention has excellent scalp odor suppression effects.

The following is a formulation example of the sebum odor suppressant composition of the present invention.

(Prescription Example 1)
Sodium polyoxyethylene lauryl ether sulfate 2.0% by mass
Polyoxyethylene (6) glyceryl monoisostearate 2.0% by mass
Polyoxyethylene (20) glyceryl monoisostearate 2.0% by mass
Lauryl amidopropyl betaine 1.0% by mass
Sodium lauroamphoacetate 0.6% by mass
Trishydroxymethylaminomethane 1.0 mass%
Diglycerin 1.0% by mass
1,3-butylene glycol 10.0% by mass
Ethanol 5.0% by mass
l-Menthol 0.5% by mass
Acrylic acid/alkyl methacrylate copolymer 0.4% by mass
pH adjuster Appropriate amount Purified water Remainder Total 100.0% by mass

(Prescription Example 2)
Sodium polyoxyethylene lauryl ether sulfate 2.0% by mass
Polyoxyethylene (8) glyceryl monoisostearate 4.0% by mass
Polyoxyethylene glyceryl ether (9) 3.0% by mass
Sodium lauroamphoacetate 0.3% by mass
Trishydroxymethylaminomethane 0.5% by mass
Dipropylene glycol 10.0% by mass
Ethanol 7.0% by mass
l-Menthol 0.3% by mass
Acrylic acid/alkyl methacrylate copolymer 0.2% by mass
pH adjuster Appropriate amount Purified water Remainder Total 100.0% by mass

(Prescription Example 3)
Sodium polyoxyethylene lauryl ether sulfate 10.0% by mass
Polyoxyethylene (6) glyceryl monoisostearate 1.5% by mass
Polyoxyethylene (20) glyceryl monoisostearate 3.5% by mass
Lauryl amidopropyl betaine 2.5% by mass
Coconut oil fatty acid diethanolamide 3.0% by mass
Lauryl dimethylaminoacetic acid betaine 4.2% by mass
Sodium lauroamphoacetate 0.6% by mass
Trishydroxymethylaminomethane 1.0 mass%
Sorbitol 1.0% by mass
1,3-butylene glycol 0.5% by mass
l-Menthol 1.0% by mass
O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethyl cellulose chloride 0.3% by mass
Polydimethylmethylene piperidium chloride solution 0.1% by mass
Ethylene glycol distearate 1.0% by mass
pH adjuster Appropriate amount Purified water Remainder Total 100.0% by mass

(Prescription Example 4)
Sodium polyoxyethylene lauryl ether sulfate 6.0% by mass
Lauryl dimethylaminoacetic acid betaine 2.0% by mass
Sodium polyoxyethylene lauryl ether acetate 3.0% by mass
Disodium lauryl sulfosuccinate 1.0% by mass
Coconut oil fatty acid diethanolamide 5.0% by mass
Sodium lauroamphoacetate 0.6% by mass
Trishydroxymethylaminomethane 1.0 mass%
O-[2-hydroxy-3-(trimethylammonio)propyl] chloride
Hydroxyethyl cellulose 0.2% by mass
Dipotassium glycyrrhizinate 0.2% by mass
l-Menthol 1.0% by mass
Ethanol 3.0% by mass
Sodium chloride (appropriate amount) Ethylenediaminetetraacetate (appropriate amount) Sodium benzoate (appropriate amount) Fragrance (appropriate amount) Purified water (remainder) Total 100.0% by mass

(Prescription Example 5)
Sodium polyoxyethylene lauryl ether sulfate 2.0% by mass
Polyoxyethylene (20) sorbitan monoisostearate 2.0% by mass
Polyoxyethylene (100) hydrogenated castor oil 2.0% by mass
Lauryl amidopropyl betaine 1.0% by mass
Sodium lauroamphoacetate 0.3% by mass
Trishydroxymethylaminomethane 0.5% by mass
Diglycerin 1.0% by mass
1,3-butylene glycol 10.0% by mass
Ethanol 5.0% by mass
l-Menthol 0.5% by mass
Acrylic acid/alkyl methacrylate copolymer 0.4% by mass
pH adjuster Appropriate amount Purified water Remainder Total 100.0% by mass

(Prescription Example 6)
Sodium polyoxyethylene lauryl ether sulfate 2.0% by mass
Polyoxyethylene (8) glyceryl monoisostearate 2.5% by mass
Polyoxyethylene (100) hydrogenated castor oil 1.5% by mass
Polyoxyethylene glyceryl ether (9) 3.0% by mass
Sodium lauroamphoacetate 0.6% by mass
Trishydroxymethylaminomethane 1.0 mass%
Dipropylene glycol 10.0% by mass
Ethanol 7.0% by mass
l-Menthol 0.3% by mass
Acrylic acid/alkyl methacrylate copolymer 0.2% by mass
pH adjuster Appropriate amount Purified water Remainder Total 100.0% by mass

(Prescription Example 7)
Sodium polyoxyethylene lauryl ether sulfate 10.0% by mass
Polyoxyethylene (50) hydrogenated castor oil 1.5% by mass
Polyoxyethylene (20) glyceryl monoisostearate 3.5% by mass
Lauryl amidopropyl betaine 1.5% by mass
Coconut oil fatty acid diethanolamide 3.0% by mass
Lauryl dimethylaminoacetic acid betaine 1.5% by mass
Sodium lauroamphoacetate 0.6% by mass
Trishydroxymethylaminomethane 1.0 mass%
Sorbitol 1.0% by mass
1,3-butylene glycol 0.5% by mass
l-Menthol 1.0% by mass
O-[2-hydroxy-3-(trimethylammonio)propyl] chloride
Hydroxyethyl cellulose 0.3% by mass
Polydimethylmethylene piperidium chloride solution 0.1% by mass
Ethylene glycol distearate 1.0% by mass
pH adjuster Appropriate amount Purified water Remainder Total 100.0% by mass

(Prescription Example 8)
Sodium laureth sulfate 10.0% by mass
Cocamidopropyl betaine 5.0% by mass
Coconut oil fatty acid N-methylethanolamide 5.0% by mass
Sodium lauroamphoacetate 0.6% by mass
Trishydroxymethylaminomethane 1.0 mass%
Polyquaternium-10 0.5% by mass
Ethanol 2.0% by mass
Phenoxyethanol 0.3% by mass
Sodium chloride (appropriate amount) pH adjuster (appropriate amount) Sodium benzoate (appropriate amount) Fragrance (appropriate amount) Purified water (remainder) Total 100.0% by mass

(Prescription Example 9)
Glycerin 15.0% by mass
Lauramidopropyl hydroxysultaine 2.5% by mass
Sodium lauroamphoacetate 0.3% by mass
Trishydroxymethylaminomethane 0.5% by mass
Sodium lauroylmethylalanine 6.0% by mass
O-[2-hydroxy-3-(trimethylammonio)propyl] chloride
Hydroxyethyl cellulose 0.3% by mass
Xanthan hydroxypropyltrimonium chloride 0.3% by mass
Polyquaternium-10 0.2% by mass
Phenoxyethanol 0.3% by mass
Glutamic acid 0.1% by mass
pH adjuster (appropriate amount) Ethylenediaminetetraacetate (appropriate amount) Sodium benzoate (appropriate amount) Purified water Remainder Total 100.0% by mass

(Prescription Example 10)
Cocoyl hydrolyzed keratin K 7.0% by mass
Lauroyl hydrolyzed silk sodium 5.0% by mass
Sodium lauroylmethylalanine 5.0% by mass
Sodium lauroamphoacetate 0.6% by mass
Trishydroxymethylaminomethane 1.0 mass%
Polyquaternium-10 0.5% by mass
O-[2-hydroxy-3-(trimethylammonio)propyl] chloride
Hydroxyethyl cellulose 0.3% by mass
PPG-2 cocamide 1.5% by mass
Ceteareth-60 myristyl glycol 1.0% by mass
Polyoxyethylene cetyl stearyl diether 0.5% by mass
Dipropylene glycol 5.0% by mass
L-arginine 0.1% by mass
pH adjuster appropriate amount Methylparaben appropriate amount Fragrance appropriate amount Purified water Remaining Total 100.0% by mass

(Prescription Example 11)
Sodium polyoxyethylene lauryl ether sulfate 15.0% by mass
Coconut oil fatty acid amidopropyl betaine 10.0% by mass
Polyoxyethylene (10) lauryl ether 5.0% by mass
Diethylene glycol distearate 2.0% by mass
Sodium lauroamphoacetate 0.6% by mass
Trishydroxymethylaminomethane 1.0 mass%
Glycerin 10.0% by mass
Palmitic acid 1.0% by mass
Stearyl alcohol 1.0% by mass
Alkyltrimethylammonium chloride 1.5% by mass
Phenoxyethanol 0.3% by mass
Polyquaternium-10 appropriate amount pH adjuster appropriate amount Ethylenediaminetetraacetate appropriate amount Sodium benzoate appropriate amount Fragrance appropriate amount Purified water Rest Total 100.0% by mass

(Prescription Example 12)
Sodium methyl cocoyl taurate 5.0% by mass
Sodium lauroyl sarcosinate 5.0% by mass
Lauryl betaine 3.0% by mass
Coconut oil fatty acid N-methylethanolamide 1.0 mass%
Ethyl isostearate 0.1% by mass
Sodium lauroamphoacetate 0.6% by mass
Trishydroxymethylaminomethane 1.0 mass%
Glycol distearate 1.0% by mass
pH adjuster appropriate amount Polyquaternium-10 appropriate amount Fragrance appropriate amount Methylparaben appropriate amount Purified water Rest Total 100.0% by mass

Claims (4)

A sebum odor inhibitor composition containing the following components (A) and (B) :
A sebum odor suppressant composition, wherein the content of component (A) in the sebum odor suppressant composition is 0.001 to 10 mass % .
Component (A): at least one polyhydroxyamine compound selected from the group consisting of trishydroxymethylaminomethane and 2-amino-2-methyl-1,3-propanediol; and Component (B): sodium lauroamphoacetate. An external skin preparation containing the sebum odor suppressant composition according to claim 1. A spray-type deodorant containing the sebum odor suppressant composition according to claim 1. A hair cleanser containing the sebum odor suppressant composition according to claim 1.