JPS591682B2 - rat poison - Google Patents

Description

[Detailed Description of the Invention] Rats have a large reproductive capacity when living conditions are suitable, and the harm they cause to human life is immeasurable in various ways.

More than economic damage to crops and forestry, damage caused by vectors of infectious diseases has caused many tragedies.

Particularly recently, black rats have been repeatedly appearing in large numbers in high-rise buildings, various buildings, underground malls, etc., at an abnormal rate depending on the location.

They cause many problems, including being vectors for infectious diseases, being contaminated by rat feces and urine, reducing product value due to bites, and cutting computer cables and other electrical cables.

Also, the discomfort caused by rats infesting these buildings cannot be overlooked.

To exterminate black rats, coumarin-based drugs have been mainly used as low-toxicity rodenticides for humans and livestock, but the emergence of drug-resistant individuals that are ineffective has been reported worldwide and has been confirmed in Japan as well. It also tends to increase every year.

Therefore, the present inventors conducted extensive research on various substances in order to find a substance that is effective in exterminating warfarin-resistant species, and as a result, they discovered that cholecalciferol is extremely effective.

Cholecalciferol is also known as vitamin D3.
Since its discovery in tuna liver oil by H.
Widely used for livestock, food additives, feed additives,
It is designated as a drug.

Although the toxicity of cholecalciferol to various animals is extremely low, it has an excellent rodenticidal effect on rats, and it is particularly unique that it has a similar effect on individuals resistant to coumarin-based rodenticides. This is a phenomenon discovered for the first time by the present inventors.

It was also found that rats do not have repellency to cholecalciferol, and it was also found that it can be used effectively as a rodenticide.

Cholecalciferol crystals have a high concentration of 40 million international units, and vitamin D3 oil has a high concentration of 2 million international units, so for actual use, it is necessary to formulate a formulation to lower the concentration of the active ingredient and maintain quality. .

The formulation may be a powder, granule, tablet, oil, emulsion, or the like.

Either cholecalciferol crystals may be first dissolved in oil or emulsion and then dispersed into powder, or those oils or emulsions may be microencapsulated and then dispersed into powder. .

Concerning rodenticidal properties, the concentration of cholecicafferol is 0.
01 to 3% by weight (4,000 to 1,200,001 U).

As a trituration agent, flour, starch, skim bran, skim milk powder,
Saccharides, talc, silicic anhydride, etc., oils such as beef tallow, vegetable oil, parasitic liquid, etc., and coating agents such as gum arabic, sodium caseinate, alginic acid, gelatin, starch syrup, etc. can be used.

Further, in formulating the formulation, it may be combined with conventional rodenticides such as warfarin, norpolmite preparations, and silyloside preparations.

Next, examples will be shown.

Mixture of flour, starch, and talc with vitamin D3 oil (
2 million international units) as cholecalciferol.
01-0.1% by weight (4000-400001, U,
), the powder was mixed with sunflower seeds and given to the children.

Example 1 (Laboratory Example) (1) Cholecalciferol was added to 0.025% by weight (
1oooo1. U,) was given to warfarin-resistant black rats.

Administered to 88 animals for 3 days 7 out of 8 died ♀Administered to 5 animals for 3 days 5 out of 5 died (2) Cholecalciferol 0.1% by weight (4
0000I, U, ) was given.

It was also given to warfarin-resistant black rats.

Administered to 88 mice for 3 days 7 out of 8 died ♀Administered for 3 days to 11 mice 0 out of 111 died As can be seen in the experimental example, the mortality rate due to feed containing cholecalciferol is extremely high.
It was also discovered that it could be used effectively as a rat poison, even though it had no repellent properties.

Example 2 (Example of field test) A field test was conducted in a restaurant area located in the basement of a reinforced concrete building.

Containers each containing 470 g of the rodenticide of the present invention were placed at four locations around the attic inspection opening on the ceiling of the hallway.

This rodenticide is 0.02% by weight (8000■, U,)
Contains cholecalciferol.

The rodenticide of the present invention was installed at 10 randomly selected inspection openings in the attic under similar conditions.

Figure 1 shows the installation of rodenticide around inspection port 1.

The results were as follows. Eating amount installation location 8 days later 14 days later 1-A OO BOO co 0 D 0 0 2-A / / B OO C00 D// 3-AO15g B 0 15g CO60g D 0 10g 4-AO50g B 0 70g CO55f D 0 35g 5-A 0 50g B O80g Co 65g D 0 50g CO55f D 0 35g CQ 20? D// 7-AOIO g B 0 15 g C030 g D'010 g Eating amount Installation location 8 days later 14 days later 8-AO20 g BO25 g C015 g DO50 g 9-A OO B 0 40 g C030? D 0 15g1O-AO83gB 30 4:l' C045gD 0 3F1 Rats in the same underground mall were randomly caught with a mouse tray sheet 12 days before the rat poison of the present invention was applied.30
It was the head.

When inspected 8 days after administering the rodenticide of the present invention, it was found that no animals had eaten it at all, but after 22 days, a considerable amount had been eaten, and the results showed that the rodenticide had been eaten.

Twenty-nine days after the trap was set, a total of 18 rats were captured using the rat tray sheet, which was about half the number of rats originally caught.

The decrease in the number of rats randomly caught by the mouse tori sheet indicates that the rats that ingested the rodenticide of the present invention died and their number decreased.

From the above examples, it was found that a rodenticide containing cholecalciferol as an active ingredient is extremely effective in exterminating rats.

Example 3 (Laboratory example) Cholecalciferol 0.025% by weight (100O
O1, U,) was given to rats.

Administered to 810 mice for 3 days 0 out of 100 died ♀ Administered to 7 mice for 3 days 7 out of 7 died Cholecalciferol prepared at 0.1 MM% (40000 I, U) was given to mice. .

Administered to 812 mice for 3 days 2 out of 122 died ♀Administered to 10 mice for 3 days 0 out of 100 died
1, U,) was given to brown rats.

Administered to 86 animals for 3 days, 5 out of 6 animals died.Administered to 7 animals for 3 days, 6 out of 7 animals died.Cholecalciferol 0.1% by weight (400C) OI
, U,) was given to brown rats.

Administered to 88 animals for 3 days 8 out of 8 died Administered to 7 female mice for 3 days 7 of 7 mice died

[Brief explanation of drawings]

FIG. 1 is an explanatory diagram showing the installation situation of rodenticide in Example 2 of the present invention.

Claims (1)

[Claims] 1 0.01~ with cholecalciferol as an active ingredient
A rodenticide characterized by low toxicity to humans and livestock, containing 3% by weight (4,000 to 1,200,000 I, U).