JPS597685B2 - Method for manufacturing vitamin preparations - Google Patents

Description

[Detailed description of the invention] The present invention relates to a method for producing stable vitamin formulations.

For further details, see (A) Vitamin K, folic acid, vitamin B
Powders of one or more of 12 or diluted thereof (hereinafter collectively referred to as core substances), (B) fats and oils with a melting point of 40 to 90°C, (C) lecithin, glycerin fatty acid monoester, One or two sucrose fatty acid esters
The present invention relates to a method for producing a vitamin preparation, which is characterized in that it is mixed in a melt with at least one seed and then coated and powdered.

The vitamin K mentioned here refers to naturally occurring K1, K
2 and its homologues, and K3, K4, K5, K6, K7 and their esters or sulfite adducts.

BACKGROUND OF THE INVENTION Vitamin K is essential for animal nutrition, is known as a blood coagulation factor, and is used as a pharmaceutical, animal drug, feed additive, and as a preservative for some foods.

For feed use, stabilized K3 agents include menadione sodium bisulfite (hereinafter referred to as MSB) and menadione bisulfite dimethylpyrimidinol (hereinafter referred to as MP).
B) are widely used, but some formulations still have insufficient stability in feed, especially in pellets.

Class K is generally sensitive to light, unstable and easily decomposed.

K1 is relatively stable to air and acids, but unstable to strong alkalis and decomposed by sunlight.

The decomposition of K3 is accelerated by high humidity, minerals and high temperature.

This substance also has the effect of irritating the skin, mucous membranes, and respiratory system.

Folic acid is chemically known as pteroylglutamic acid, and is also called foliic acid or foramin, and is known as a factor related to nutritional anemia.

Folic acid is sensitive to light and is degraded gradually by weak light such as indoor light, and rapidly by direct sunlight or ultraviolet light.

It is also easily decomposed by acids (pH 6.0 or less), sulfites, and other redox agents.

Vitamin B1 is also called cyanocobalamin and is known as an anti-anemia factor.

Vitamin B12 is a weak polyacid base.

It has hygroscopic properties and becomes unstable under high humidity, and is also sensitive to strong light. It will decompose if left for a while.

Although it is most stable at pH 4.5 to 5.0, if it is left for a long time in strongly acidic or alkaline conditions, various decomposition reactions including hydrolysis of acid amide will occur.

As described above, humidity, temperature, light, minerals, pH 1 redox agents, etc. have a significant effect on the stability of vitamin K, folic acid, and vitamin B1.

So vitamin K, folic acid and vitamin B1.

In order to stabilize vitamins, it is effective to cut off contact with these factors, so we use hydrogenated oil and introduce an oil-soluble emulsifier to increase the affinity between the hydrogenated oil and vitamins. The present invention was completed as a result of extensive testing to find the optimal combination.

That is, the present invention uses (A) a core material, (B) a melting point of 40 to
This relates to a method for producing a vitamin preparation in which the mixture is mixed into a melt of 90°C oil and fat and one or more of ('C) lecithin, glycerin fatty acid monoester, and sucrose fatty acid acid ester, and then coated and powdered. .

The fats and oils with a melting point of 40 to 90°C referred to in the present invention are not particularly limited, but include hydrogenated beef tallow, hydrogenated lard, hydrogenated fish oil,
Hydrogenated whale oil, hydrogenated chicken fat, hydrogenated gum oil, hydrogenated rapeseed oil, hydrogenated soybean oil, hydrogenated coconut oil, hydrogenated castor oil, etc. may be used alone or in combination of two or more.

Moreover, a part of these fats and oils can also be replaced with glycerol fatty acid diester.

The glycerin fatty acid monoester referred to in the present invention has 8 carbon atoms.
As long as it is a monoester of ~22 fatty acids, it may be saturated or unsaturated.

For example, glycerin monostearate, monooleate, monolaurate, etc. are commonly used.

Furthermore, sucrose fatty acid esters with low HLB (1 to 6) are preferable for the purpose of the present invention.

When one of lecithin, glycerin fatty acid monoester, and sucrose fatty acid ester is used in the coating material of the present invention, the amount is 0.1 to 1 part by weight per 1 part by weight of oil and fat; lecithin, glycerin fatty acid monoester, Similarly, when two or more types of sucrose fatty acid esters are used in combination, the total amount is preferably 0.1 to 1 part by weight per 1 part by weight of oil or fat.

The coating agent of the present invention is used in an amount of 1 to 200 parts by weight per 1 part by weight of the core material.

The mixture of the present invention, in which a core material is added to the coating melt, has a good dispersion or dissolution state and good dispersion or dissolution stability.

Here, other vitamins can also be mixed at the same time.

As a means for pulverizing this mixture, for example, by spraying it into a room controlled at 35° C. or lower using a rotating disc type sprayer, a powdery product with a particle size of about 50 to 800 μm can be obtained.

The means for pulverization is not limited to the above-mentioned method, but can be pulverized by any appropriate method.

If the amount of coating material is less than 1 part by weight based on the core material, the viscosity of the suspension obtained by dispersing or dissolving the core material in the molten coating material will be very high, making it difficult to spray, atomize, or granulate. This makes it difficult to obtain the desired coated particles.

Moreover, if the amount exceeds 200 parts by weight, the effect of increasing the coating agent will not be recognized in terms of storage stability, and the cost per unit of vitamins will be too high, which is not preferable.

Since the stability of vitamins is significantly improved by the coating method of the present invention, the product of the present invention is useful for dogs in powdered vitamin mixtures, vitamin/mineral mixtures, mixed feeds, and the like.

Furthermore, vitamin K3 may irritate the skin, mucous membranes, respiratory organs, etc. when handled, but it is safe when coated and powdered using this method.

The present invention will be explained below using examples and experimental examples, but the present invention is not limited to these examples.

Note that unless otherwise specified, parts refer to parts by weight.

Example 1 A coating consisting of 60 parts of hardened beef tallow with a melting point of 61°C and 10 parts of lecithin was melted and MPB was poured into the mixture while keeping the temperature at 70 to 90°C.
Add 30 parts of crystals (or MSB crystals, folic acid crystals, and vitamin B12 powder (10% triturated powder) each individually), and while stirring and mixing uniformly, spray into a room at 35°C or lower with a rotating disc sprayer. MPB, M of 50 to 300μ each
Coated particles of SB, folic acid, and vitamin B12 were obtained.

Example 2 A coating material consisting of 60 parts of hydrogenated soybean oil with a melting point of 69°C, 10 parts of lecithin, and 10 parts of glycerin monostearate was melted, and 20 parts of MSB crystals were added to the mixture while maintaining the temperature at 75 to 100°C, and the mixture was uniformly mixed. 3 using a nozzle type sprayer while stirring and mixing.
Spraying indoors at temperatures below 5℃? Coated particles of 70 to 500 μm were obtained.

Example 3 A coating material consisting of 50 parts of hydrogenated rapeseed oil with a melting point of 63°C and 14 parts of sucrose fatty acid ester (DKSF-50, HLB6, manufactured by Daiichi Kogyo Seiyaku) was melted, and MPB crystals were placed in the mixture kept at a temperature of 70 to 90°C. 20 parts, 8 parts of folic acid crystals, and 8 parts of vitamin B12 crystals were added thereto, and coated particles of 50 to 400 μm in size were obtained in the same manner as in Example 1 while stirring and mixing uniformly.

Example 4 Hardened beef tallow with a melting point of 61°C, 5 parts of lecithin, sucrose fatty acid ester (S-370 manufactured by Hishito Co., Ltd., HLB 2-3
) and 10 parts of glycerin monooleate were melted, 15 parts of MPB crystals were added to the mixture kept at a temperature of 70 to 90°C, and the mixture was heated in the same manner as in Example 2 while stirring and mixing uniformly. Coated particles of 500μ were obtained.

Example 5 20 parts of hydrogenated palm oil with a melting point of 59°C, 40 parts of hardened chicken fat with a melting point of 60°C, sucrose fatty acid ester (DK manufactured by Daiichi Kogyo Seiyaku Co., Ltd.)
A coating material consisting of 10 parts of SF-10, HLBI) and 10 parts of glycerin monolaurate was melted and heated to a temperature of 70 to 90°C.
20 parts of MSB crystals and 8 parts of folic acid crystals were added in the same manner as in Example 1 while stirring and mixing uniformly.
Coated particles of 0μ were obtained.

Example 6 80 parts of cured chicken fat with a melting point of 60°C, glycerin monobehenene
}10 parts of lecithin was melted, 0.5 parts of vitamin B1 crystals were added to the mixture kept at a temperature of 70 to 90°C, and the same procedure as in Example 1 was carried out while stirring and mixing uniformly. Coated particles of 600μ were obtained.

Test Examples Stability tests were conducted under the following conditions for Examples, vitamin powder before coating, and Comparative Examples prepared using only hardened beef tallow as a coating agent in the same manner as in Example 1.

(1) Sample premix; Commercially available premix feed for chickens; Commercially available broiler feed Each vitamin is added to the above sample to achieve the concentration shown in (2) and mixed uniformly.

(2) Concentration of vitamins MSB: 50 ppm MPB: 50 ppm Folic acid: 20 ppm Vitamin B: 20 ppm 12 In addition, when two or more vitamins were used together, they were adjusted to the above concentrations.

(3) Stability test conditions 50 grams of a sample was placed in a 100 ml brown glass bottle and sealed, and after 8 weeks under the following conditions, the content of each vitamin was measured.

Premix; 40°C Feed; 30°C (4) Method for quantifying vitamins MSB: E. Leerbeck et al. (Acta A
gricul-turae S candinavi
ca25 (1975)) method (D
(NP colorimetric method).

MPB; folic acid as above. A, 0. A. Vitamin B12 according to C■; U. S. From the above results, which are similar to those of PXIX, the vitamins coated by the method of the present invention are significantly superior even in particularly unstable feeds, as can be seen in comparison with the comparative example.

Claims (1)

[Claims] 1 (A) Vitamin K, folic acid, vitamin B12 1
The seed or two or more are mixed into a melt of (B) an oil or fat with a melting point of 40 to 90°C and (C) one or more of lecithin, glycerin fatty acid monoester, and sucrose fatty acid ester to form a coated powder. A method for producing a stable vitamin preparation characterized by: