JPS6056682B2 - cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a cosmetic containing lanolin fatty acid triglyceride, in other words, a skin cosmetic that can impart an unprecedented feel and emollient effect to the skin.

The functions of the human skin include regulating the evaporation of moisture from within and controlling the infiltration of foreign substances from the outside, and the lipids that are thinly spread on the surface of the skin play a role in these protective functions. I'm in charge.

Most of this lipid is sebum derived from sebaceous glands, and about 28-48% of this sebum is called triglyceride, and its constituent fatty acids are about 45% linear saturated fatty acids and 48% linear unsaturated fatty acids. It is said to contain about 7% branched fatty acids. In addition, branched fatty acid esters have a lower melting point than straight-chain fatty acid esters due to steric hindrance, and they form a thin film that spreads easily on the skin surface, naturally providing softness and moisture to the skin, but also preventing the skin from breathing. It maintains healthy skin. Conventionally, vegetable oils such as olive oil or animal fats and oils such as mink oil have been used as triglycerides in skin cosmetics, but since their constituent fatty acids are only straight chain fatty acids, they cannot provide a satisfactory feel.

In addition, lanolin contains branched fatty acid esters and has unique flexibility and permeability, so it is often added to skin cosmetics, but there is no triglyceride type, and there is no ester type with alcohol. Most of them are. However, since most of the sebum in the human body is of the triglyceride type as mentioned above, the ester type of lanolin and alcohol is insufficient to provide a physiologically natural feel. Furthermore, it is a well-established theory that the alcohol part in lanolin causes contact dermatitis. This is also clear from the following table showing the results of the lanolin fraction patch test. 1 No abnormality 2 Normal + Abnormality (small) 2 Abnormality (medium) -1 + F Abnormality (major) The present invention is the synthesis of a novel lanolin fatty acid triglyceride that does not have the disadvantages of purified lanolin and known lanolin derivatives. This product was developed based on the success of this method, and is characterized by incorporating this lanolin fatty acid triglyceride into a cosmetic ingredient.

That is, in detail, a novel lanolin fatty acid triglyceride consisting of normal type fatty acid, isotype fatty acid, anteiso type fatty acid, and hydroxy type fatty acid is 1.0 to 8. This is a skin cosmetic compounded with cosmetic ingredients, which gives the skin a new feel and an excellent emollient effect.

Here, an example of synthesis of lanolin fatty acid triglyceride applied to the present invention will be shown.

[Synthesis Example 1] A mixture consisting of lanolin fatty acid 186y1 glycerin 18f1 toluene 500ml and balatoluenesulfonic acid 2f was heated at 120'C for 8 hours, stirred and refluxed, and then the reaction mixture was mixed with water, saturated sodium bicarbonate solution, 0.1N hydrochloric acid solution, After sequentially washing with saturated saline and drying over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure, and the residue was purified by molecular distillation to obtain the desired triglyceride portion, a yellowish brown wax 1.
58fI was obtained.

This crude triglyceride was mixed with bone charcoal for 10 minutes in methanol.
0f, and the filtration solvent was distilled off to remove the wax. Pale yellow purified lanolin fatty acid triglyceride 140f
I got I. [Synthesis Example 2] 200 y of lanolin fatty acid was dissolved in 11 methanol,
Dry hydrogen chloride gas was blown in at a rate of 0.2'/hour for 8 hours to fully saturate the hydrogen chloride gas, and the reaction mixture was left to stand for 1 hour. After distilling off the solvent under reduced pressure, ethyl ether 1'
Dissolved in water, washed sequentially with water, saturated sodium bicarbonate solution, and saturated saline solution,
Next, the solvent was distilled off under reduced pressure and then distilled under reduced pressure to obtain lanolin fatty acid methyl ester 183y.

A mixture of lanolin fatty acid methyl ester 180f, glycerin 16y1, toluene 500ml, and sodium methoxide 2y was heated at 120°C for 1 hour, stirred, and refluxed, and then the reaction mixture was cooled, followed by water, 0.1N hydrochloric acid, water, and saturated saline. After successively washing with water and drying with anhydrous sodium sulfate, the solvent was distilled off under reduced pressure, and the residue was purified by molecular distillation to obtain yellow wax 162f as the desired triglyceride moiety. This crude triglyceride was further treated with bone char to obtain 154 g of waxy pale yellow purified lanolin fatty acid triglyceride. Next, examples of the present invention will be shown.

The mixing ratio of each component is in parts by weight. [Example 1] Emollient cream (0/W cream) Human ingredients: 80
Dissolved uniformly at ~90'C and maintained at 75-85°C, gradually added component B at 75-85°C with stirring to emulsify, and then cooled with water to 3 (generations) while stirring. 2m
After leaving it for a while, it is filled into a container and used as a product.

[Example 2] Moisture lotion (0/W milk) component B was 70%
Maintained at ~80°C, component A uniformly dissolved at 70-80°C and maintained at 70-80°C was gradually added with stirring to emulsify, and then cooled with water to 30°C while stirring,
After standing for 2C@, fill it into a container and use it as a product.

Next, lanolin fatty acid ester (hereinafter referred to as PAT) obtained in Synthesis Example 1, and lanolin fatty acid isopropyl ester (hereinafter referred to as A) as a known ester, disclosed in JP-A-50-13544. Mono 2-ethylhexanoic acid glycerin ester (hereinafter referred to as B
1) and di-2-ethylhexanoic acid glycerin ester (hereinafter referred to as 8), tri-2-ethylhexanoic acid glycerin ester (hereinafter referred to as (hereinafter referred to as C), trimyristate glycerin ester (hereinafter referred to as D) to induce insensible excretion (transepidermal water loss,
The results of measuring the TWL (hereinafter abbreviated as TWL) are shown in the attached drawings.

In addition, TWL is one of the ways in which water is lost in the stratum corneum, and suppression of TWL is an important function of basic cosmetics.
A substance with a smaller value of L has a stronger effect of retaining moisture in the stratum corneum. The measurements were carried out by having 5 subjects rest in a constant temperature room at 20-21℃ for about 3 minutes, and measuring the inner forearm of 4 x 5 cm. 0.1f of each of the above samples to i
Pp was applied, a skin cup was fixed on the area, and the moisture that passed through the skin cup after one dusting was measured using a Toshiba Beckman electrolytic moisture measuring device.
Conversion from m to M9/C7lTIh was performed according to the method of Spruit.

From the drawing, it is clear that PAT and A have smaller TWL values than Bl, B2, C, and D, and that PAT has a smaller TWL value than PAT<15A, and PAT is a known It can be seen that the effect of retaining moisture in the stratum corneum is stronger than that of esters.

Furthermore, Table 1 shows the results of measuring the water-retentivity of PAT and known esters.

The measurement method is to accurately weigh each sample in an agate pot for about 2y, add water to it while kneading, and take the amount of water added before it stops mixing as the amount of water taken into the sample, and calculate the y number of the sample (
Calculate the ratio Y/X x 100 between X) and the number of ml of water (Y).
I went there by doing this. From this, PAT is A, Bl, B
It has much better water-holding ability than 2, and C.
It can be seen that , D has no water-retaining property.

In addition, although A is comparable to PAT in TWL, it is clear that it is significantly inferior to PAT in water-holding ability.
It can be seen that AT is more effective in moisturizing the skin than known esters. Furthermore, in order to confirm the effect as a cosmetic, Examples 1 and 2 and Comparative Examples 1 and 2 in which lanolin fatty acid triglyceride was replaced with olive oil were subjected to a sensory test in which 100 women with 25 to 5 vomiting were used continuously for 10 days. The results were as shown in Table 2.

Furthermore, Example 1 and its lanolin fatty acid triglyceride were combined with the above-mentioned known esters A, Bl, B2, C,
Regarding comparison products 1, 2, 3, 4, and 5 replaced with D, 2
Table 3 shows the results of a sensory test conducted on 50 women with grades 3 to 507 for 10 days. From the above Tables 2 and 3, it is clear that the cosmetics according to the present invention have significantly superior effects in all the sensory test items compared to the comparative examples and comparative products, which is unprecedented. Some provide a tactile and emollient effect to the skin.

[Brief explanation of the drawing]

The drawing shows insensible excretion (TW) measured using lanolin fatty acid triglyceride used in the present invention and known esters.
It is a graph showing the result of L).

Claims (1)

[Claims] 1. A cosmetic comprising lanolin fatty acid triglyceride as a cosmetic ingredient.