JPS6126966B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to toothpaste compositions suitable for plastic containers. Toothpaste compositions are usually used in a tube and are extruded from the tube when used. Therefore, it is necessary that the composition be easy to extrude from the tube, have appropriate shape retention, and be easy to apply on a toothbrush. It also needs to be hygienic. Conventionally, toothpaste tubes can be roughly divided into aluminum tubes, laminate tubes made of aluminum foil coated on both sides with plastic, and plastic tubes made only of plastic. When you look,
In the case of aluminum tubes, corrosion, pitting, etc. may occur, and in order to solve this problem, measures have been used such as improving the formulation of the contents or changing the container to a plastic tube. Recently, toothpaste compositions have also been housed in plastic containers 1 having bottle-shaped bottoms 1a as shown in FIGS. 1 and 2. The walls of these containers 1 are relatively thick, and after the contents are removed by pressing, they immediately return to their original shape when the pressing force is released, and they have a good appearance. Since the cap body 2 can be placed face down, it is also easy to store. Conventionally, when toothpaste compositions are stored in these plastic containers (plastic containers, plastic tubes, laminate tubes made of aluminum foil laminated with plastic on both sides, etc. as shown in Figures 1 and 2), they are particularly large. Although no problems were observed, experiments by the inventors showed that when using these plastic containers, which are easier to restore than aluminum tubes, they were more likely to be used than aluminum tubes if the contents were contaminated by the environment. It was discovered that common bacteria sometimes tend to proliferate. If non-pathogenic but common bacteria are present in large quantities, the stability of the flavor may be impaired. Therefore, if a plastic container is used, especially one with high resilience, the preservative power of the toothpaste composition should be reduced. It was recognized that there was a need to improve. Generally, conventional toothpaste compositions contain preservatives and bactericidal agents to increase their preservative power. However, there are reports that, for example, quaternary ammonium salt-based bactericides stain teeth, and the upper limit of the amount of these preservatives and bactericides is stipulated by law, especially in the oral cavity. In dentifrice compositions used in dentifrice compositions, it is desirable to reduce the amount of preservatives, bactericides, etc. contained in them as much as possible in order to further increase stability. In view of the above circumstances, the present inventors have high preservative power,
As a result of intensive research in order to obtain a toothpaste composition suitable for use in plastic containers, which is also highly safe in use, we found that polyhydric alcohol, which is conventionally used as a thickening agent in the production of toothpaste compositions, was added to the usual formulation. Add polyhydric alcohol to the toothpaste composition in a large amount exceeding the amount, that is, in such a manner that the molar concentration of the polyhydric alcohol (the number of moles of polyhydric alcohol in 1 water in the toothpaste composition) is 6.3 or more and 100 or less. When mixed in (the usual amount of polyhydric alcohol is about 5 moles/
It's water. ), surprisingly, the preservative power of the toothpaste composition increases significantly, and when it is stored in a plastic container, it can inhibit the growth of general bacteria as effectively as when it is stored in an aluminum tube, and it has a temporary effect. We have discovered that even if there is a large amount of contamination, it is possible to reduce the contamination in a relatively short period of time.
Furthermore, it was discovered that the preservative power could be further improved by adding a fluoride such as sodium monofluorophosphate to this, and the present invention was achieved based on this finding. Furthermore, it has been found that when an alkali metal salt of carboxymethylcellulose is added as a binder together with the polyhydric alcohol, the preservative power is further strengthened. In addition, by using an alkali metal salt of carboxymethylcellulose with an average degree of etherification (DS) of 0.75 to 0.9, it is possible to maintain a moderate shape retention property. When used in a container, the fluidity of the contents increases as the container is pressed many times to extrude the toothpaste composition, and the shape retention is better than when using an aluminum tube. However, it has been found that by using the carboxymethyl cellulose salt described above, it is possible to prevent the deterioration of the shape retention of toothpaste compositions even when the container is pressed a considerable number of times. It has been reached. The present invention will be explained in detail below. The toothpaste composition according to the present invention can be used in plastic containers such as plastic containers with a large restoring force as shown in FIGS. 1 and 2, plastic tubes, and laminate tubes in which both sides of aluminum foil are laminated with plastic or the like. The toothpaste composition contains 6.3 to 100 moles of polyhydric alcohol based on the water content of the toothpaste composition. In this case, the polyhydric alcohols include propylene glycol, 1,3-butylene glycol, glycerin, sorbitol, xyrite, maltate,
One or more types of lactites can be used. As mentioned above, the blending amount of these polyhydric alcohols is 6.3 moles per 1 water in the toothpaste composition.
~100, and by setting the amount of polyhydric alcohol in this range, we can solve the technical problem of suppressing the growth of general bacteria and increasing the preservative power of toothpaste compositions when used in plastic containers. This is the first time I have achieved this. On the other hand, when the number of moles is less than 6.3, sufficient preservative power cannot be obtained, and in particular, when the number of moles is around 5, which is the usual amount of polyhydric alcohol blended, there is not much preservative power when stored in a plastic container. In addition, the effect increases as the number of moles of polyhydric alcohol increases, but from the viewpoint of ease of use in toothpaste and economic efficiency, the upper limit is 100, preferably 50, and more preferably extrusion hardness and threadability. In view of the above, it is preferable to set the upper limit to 15. Therefore, the optimal value for the number of moles of polyhydric alcohol is 6.3 to 15
It is. Furthermore, in the present invention, a fluoride is blended together with a polyhydric alcohol, and the preservative power can be further improved by blending the fluoride. As the fluoride, stannous fluoride, sodium fluoride, sodium monofluorophosphate, etc. can be used, but for tooth brushing, an alkali metal salt of monofluorophosphate such as sodium monofluorophosphate is preferable. The amount of these fluorides blended is preferably the amount normally blended in toothpaste compositions, that is, 500 to 2,000 ppm as fluoride ions, and within this range, a sufficient antiseptic effect is imparted, as well as a dentin strengthening effect. In the present invention, it is preferable to incorporate an alkali metal salt of carboxymethylcellulose as a binder, and by incorporating the alkali metal salt of carboxymethylcellulose, the preservative power of the toothpaste composition is further increased. In this case, it is preferable to use an alkali metal salt of carboxymethyl cellulose with an average degree of etherification of 0.75 to 0.90, and by using carboxymethyl cellulose in this range, appropriate shape retention is imparted,
Hold. In contrast, the average degree of etherification is 0.75.
If it is smaller, the shape retention is too strong and the toothpaste will roll off more easily than a toothbrush during use. on the other hand
If it exceeds 0.90, the container will be pressed many times and its shape retention will be inferior to when using an aluminum tube, so it will flow more easily than a toothbrush. The amount of carboxymethylcellulose to be blended is 0.2 to 5% by weight, especially 0.5% by weight of the entire toothpaste composition.
It is preferable to set it as 2 weight%. As other components of the toothpaste composition of the present invention, known components can be used, such as dibasic calcium phosphate dihydrate, dibasic calcium phosphate dihydrate, etc.
Abrasives such as anhydrous salt, tertiary calcium phosphate, calcium carbonate, calcium sulfate, aluminum hydroxide, insoluble sodium metaphosphate, calcium pyrophosphate, silicic anhydride (compounding amount usually 5 to 70% by weight, preferably 10 to 60% by weight) , sodium lauryl sulfate, sodium N-lauroyl sarcosinate, N-long chain acyl glutamate, sucrose fatty acid ester, lactitol fatty acid ester, fatty acid glyceride, anionic and nonionic active agents, and other foaming agents (usually 0.2~ 5% by weight), and sweeteners such as saccharin and glycyrrhizic acid,
Flavoring agents such as spearmint and peppermint, preservatives such as ethyl paraoxybenzoate and butyl paraoxybenzoate, as well as bactericidal agents, enzymes, and various other active ingredients can be added. It should be noted that there is no problem in further blending other than polyhydric alcohol as a thickening agent, and other binders other than carboxymethyl cellulose such as carrageenan, sodium alginate, polyvinyl alcohol, vegum, etc. may be used alone as a binder. Alternatively, it can be used in combination with carboxymethylcellulose. The toothpaste composition of the present invention is produced by appropriately combining the above-mentioned components and kneading them in water, and is used by storing the composition in a plastic container. In this case, the toothpaste composition according to the present invention contains a polyhydric alcohol at a ratio of 6.3 to 100 moles per water in the toothpaste composition, and also contains a fluoride, which makes it extremely effective. It has high preservative power, and even if a large amount of temporary contamination occurs, it can reduce the contamination in a relatively short period of time, and it can effectively suppress and reduce the growth of general bacteria, so it has high resilience. Even when stored in large plastic containers, it can be stored stably for a long time and maintains good quality. Moreover, the preservative power is increased simply by combining polyhydric alcohol and fluorine compounds.
In particular, the amount of preservatives and bactericides can be reduced as much as possible, and the safety in use is also high. Further, when a salt of carboxymethyl cellulose, especially one with an average degree of etherification of 0.75 to 0.90, is used as a binder, the preservative power can be further improved, and the shape retention property can be maintained at a suitable level. Next, experimental examples will be shown to further specifically explain the effects of the present invention. Experimental Example Toothpaste compositions having the formulations shown in Table 1 were produced by a conventional method.

[Table] Next, using each of the above toothpaste compositions, their preservative power was examined by the following method. <Experimental method> Gram-negative bacilli (hereinafter referred to as “A”) isolated from the environment
This A bacterium was smeared onto a trypto soy plate medium from a preservation slant, and after culturing at 32°C for 48 hours, the bacteria that had grown on the plate was scraped off.
A concentrated bacterial solution was prepared by suspending the cells in sterile physiological saline. Next, add 10 ⁶ of the above bacterial solution to the toothpaste composition of each formulation.
After inoculating at ~ ⁰⁷ /g and mixing thoroughly, it was packed into a laminated tube with plastic laminated on both sides of aluminum foil, stored at 30℃, and kneaded over time (2 weeks, 1 month). The number of viable bacteria in the dentifrice composition was measured. The results are shown in Table 2.

【table】

[Table] As is clear from the results in Table 2, when the molar concentration of polyhydric alcohol is 6.3 mol/or higher, the preservative power increases, and the effect is exerted within two weeks, and after one month, no viable bacteria remain. It was found that the number was less than 10/g. Furthermore, when sodium monofluorophosphate is blended, the effect is exhibited within one week when the molar concentration of polyhydric alcohol is 6.3 mol/or higher, and the effect is superior to that without fluoride. It was found that it became stronger. In addition, in the above experiment, each sample was housed in an aluminum tube instead of the above laminate tube and a similar experiment was carried out, but in the case of any sample (regardless of the molar concentration of the polyhydric alcohol) The number of surviving bacteria was determined as ± or -. In addition, when we conducted the same experiment as above using toothpaste compositions No. 1 and 6 for bacteria B and C (both negative rods isolated from the environment), which are different from bacteria A, the results were similar to those above. results were obtained, and the effectiveness was reconfirmed. In addition, the laminate tube contained in the above laminate tube
Even when toothpastes No. 1 to No. 9 were extruded several times, their shape retention was moderate. Examples are shown below.

[Table] Butyl

[Table] The above composition was filled into a plastic tube.

[Table] The above composition was filled into a plastic tube.

[Table] Mu

[Table] The above composition was filled into a laminated tube made of aluminum foil laminated with plastic on both sides.

[Table] Rium

[Table] The above composition was filled into a plastic container having the shape shown in FIG.

[Brief explanation of the drawing]

FIGS. 1 and 2 are perspective views each showing an example of a plastic container used to house the dentifrice composition of the present invention.

Claims (1)

[Scope of Claims] 1. In a toothpaste composition housed in a plastic container, a polyhydric alcohol is blended at a ratio of 6.3 to 100 mol/based on the water content in the toothpaste composition, and a fluoride A toothpaste composition characterized by containing the following. 2. The toothpaste composition according to claim 1, wherein the fluoride is an alkali metal monofluorophosphate. 3 The amount of fluoride contained is 500% as fluorine ion.
The toothpaste composition according to claim 1 or 2, which has a content of 2000 ppm. 4. The toothpaste composition according to any one of claims 1 to 3, wherein the polyhydric alcohol is blended in an amount of 6.3 to 15 moles per water in the toothpaste composition. 5 The polyhydric alcohol is propylene glycol,
The toothpaste composition according to any one of claims 1 to 4, which is one or more selected from the group consisting of 1,3-butylene glycol, glycerin, xylitol, maltitrate, lactitate, and sorbitol. thing. 6. The toothpaste composition according to any one of claims 1 to 5, which contains an alkali metal salt of carboxymethylcellulose as a binder. 7. The toothpaste composition according to claim 6, wherein the alkali metal salt of carboxymethyl cellulose has an average degree of etherification of 0.75 to 0.90.