JPS6217966B2 - - Google Patents

Description

[Detailed description of the invention]

In the present invention, the average number of moles of ethylene oxide added is
The present invention relates to an oral composition comprising 50 moles or less of polyoxyethylene hydrogenated castor oil in combination with an anionic activator. Oral compositions such as toothpaste usually contain an anionic active agent such as sodium lauryl sulfate as a foaming agent, which also functions as a dispersant for fragrances and the like. However, the use of only an anionic activator such as sodium lauryl sulfate has little ability to solubilize perfumes, particularly low polar perfume components and oily components. That is, many fragrances are lipophilic, and in particular, hydrocarbon components contained in natural essential oils have weak hydrophilicity, and it is difficult to sufficiently dissolve and disperse these fragrances using anionic activators alone. For this reason, peppermint oil and spearmint oil, which have traditionally been widely used as flavoring agents in oral compositions, contain a large amount of monoterpenes that are poorly soluble in water, and when used in large amounts, they can be solubilized only by the anionic activator. Since it is difficult to do this and there is a limit to the amount of menthol that can be used, comparatively hydrophilic menthol and carvone are added as supplements to prevent the flavor from deteriorating. Also,
Similarly, oil-soluble components such as pigments and oil-soluble vitamins are not sufficiently dissolved and dispersed using anionic activators alone. Therefore, in order to facilitate the dispersion and solubilization of these fragrances and oil-soluble components, it is desirable to further enhance the solubilizing power of oral compositions. In addition, from the viewpoint of commercial value, oral compositions such as toothpaste must have high storage stability and no liquid separation during storage. Furthermore, they must be extrudable from tubes and can be stored at low temperatures. Another important property is that it can be extruded smoothly from the tube even after long-term storage, and since oral compositions are used in the oral cavity, it is desirable that they have a good feel when used. In view of the above circumstances, the present inventors have made efforts to develop an oral composition that has excellent ability to disperse and solubilize fragrances and oil-soluble ingredients, has good storage stability, is resistant to liquid separation, and is comfortable to use. As a result of research,
It has been found that the above object can be effectively achieved when polyoxyethylene hydrogenated castor oil having an average number of added moles of ethylene oxide of 50 moles or less is used in combination with an anionic activator. That is, conventionally, polyoxyethylene hydrogenated castor oil (hereinafter referred to as POE (60 moles) hydrogenated castor oil) with an average number of moles of ethylene oxide added of 60 moles is used in combination with anionic activators such as acylamino acids and sodium lauryl sulfate. In addition, it is known that sodium chloride is added to this (Japanese Patent Publication No. 55-6611, JP-A No. 54-20142, 54-
59340, 56-113709, 57-106606). However, according to the results of the study by the present inventors, POE (60 mol)
Oral compositions containing hydrogenated castor oil in combination with an anionic activator are prone to liquid separation, and especially in systems that do not contain sodium chloride, liquid separation is so severe that they are unusable and impair commercial value. Also,
When POE (60 mol) hydrogenated castor oil is used in combination with an anionic activator, especially in systems containing sodium chloride, the feeling of use is poor, especially aftertaste, the foaming rate is insufficient, and the extrudability at low temperatures is poor. When stored at low temperatures for a long period of time, the ease of extrusion from the tube was reduced. However, when the average number of moles of ethylene oxide (EO) added was 50 moles, 40 moles, 30 moles, 20 moles, and 10 moles,
0.1 to 3% by weight of the entire composition of at least one selected from polyoxyethylene hydrogenated castor oil, and a water-soluble salt of a higher alkyl sulfate having an alkyl group of 8 to 18 carbon atoms and/or an α-olefin sulfate. Add water-soluble salt of fonic acid to 0.5 to 0.5% of the total composition
When POE (60 mol) is used in combination with 5% by weight, the drawbacks that occur when using POE (60 mol) hydrogenated castor oil are surprisingly solved, liquid separation is less likely to occur, and extrusion from the tube at low temperatures is improved. It has good properties, is extruded smoothly from the tube even after long-term storage at low temperatures, has a good aftertaste, has a fast foaming rate, is easy to use, and has good dispersibility of fragrances and oil-soluble ingredients. The present invention was based on the discovery that oral compositions can be obtained. The present invention will be explained in more detail below. The oral composition according to the present invention has an average number of added moles of ethylene oxide (EO) of 50 moles, 40 moles, and 30 moles.
at least one selected from polyoxyethylene (POE) hydrogenated castor oil, mol, 20 mol and 10 mol.
Contains 0.1 to 3% by weight of seeds based on the total composition, and water-soluble salts and/or α-
The composition contains a water-soluble salt (for example, sodium salt) of olefin sulfonic acid in an amount of 0.5 to 5% by weight based on the total composition. Note that among the POE hydrogenated castor oils having an average number of EO added moles of 50 moles or less, POE hydrogenated castor oils having an average number of EO added moles of 20 and 40 moles are preferably used. In addition, in the present invention, if necessary, other anionic activators may be used, such as water-soluble higher fatty acid monoglyceride sulfonates whose fatty acid group has 10 to 18 carbon atoms, such as sodium lauryl monoglyceride sulfonate and sodium coconut monoglyceride sulfonate. higher fatty acid sodium monoglyceride monosulfate, sodium N-
Methyl-N-palmitoyl tauride, Sodium-N-lauroyl sarcosinate, Sodium-N
A salt of an amide of a higher fatty acid having a fatty acid group having 12 to 18 carbon atoms such as -lauroyl-β-alanine and a lower aliphatic amino acid can also be blended. The oral composition of the present invention has an average
By using POE hydrogenated castor oil with an EO addition mole of 50 moles or less and an anionic activator, liquid separation is difficult to occur, and even in systems that do not contain sodium chloride, POE (60 moles) hydrogenated castor oil It does not have the disadvantage of significant liquid separation that occurs when oil is used, and is therefore suitable for use in systems that do not contain sodium chloride. Even when used in sodium chloride-containing systems, it has good low-temperature extrudability, has a good aftertaste, has good foaming properties, and has an excellent feel when used. It is also suitably used. In addition, when blending sodium chloride, the blending amount is preferably 3 to 30% of the total composition. If the amount is less than 3%, the benefits of adding sodium chloride will not be fully exhibited, and in particular, the salty taste will not be imparted sufficiently. Moreover, if it is more than 30%, the usability may deteriorate. In addition, the oral composition of the present invention has good dispersibility of fragrances and oil-soluble components due to the combined use of POE hydrogenated castor oil with an average number of added moles of EO of 50 moles or less and an anionic activator. , fragrances, especially those containing a large amount of monoterpenes such as peppermint oil and spearmint oil, and lipophilic ones can be used in large amounts by increasing their solubility and dispersion ability, and pigments,
Oil-soluble ingredients such as oil-soluble vitamins can also be blended with good dispersibility. Incidentally, examples of fragrances suitably used in the present invention include peppermint oil, spearmint oil, menthol, carvone, anethole, eugenol, methyl salicylate, limonene, ocimene, n-decyl alcohol, citronellol, α
-Terpineol, methyl acetate, citronellyl acetate, methyleugenol, cineole, linalool, ethyllinalool, vanillin,
Examples include thymol, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, wintergreen oil, clove oil, eucalyptus oil, etc. In the present invention, these fragrances are used alone. or in combination 0.1 to 10% of the total, preferably 0.5 to 5%
Can be mixed to some extent. The oral composition of the present invention is applied as a dentifrice such as a toothpaste, and in the present invention, appropriate commonly used ingredients may be further blended depending on the type of the oral composition. . For example, in the case of toothpaste, dibasic calcium phosphate dihydrate and anhydride, dibasic calcium phosphate, dibasic calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, silicic anhydride, silica gel, aluminum silicate , insoluble sodium metaphosphate, tertiary magnesium phosphate, magnesium carbonate, calcium sulfate, polymethyl methacrylate, bentonite, zirconium silicate, synthetic resin, etc. (compounding amount usually 20 to 60%). %). In addition, in the case of paste compositions such as toothpaste, cellulose derivatives such as carrageenan, sodium carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, sodium carboxymethylhydroxyethylcellulose, and alkali metal alginates such as sodium alginate are used as binders. , alginate propylene glycol ester,
Gums such as xanthan gum, trangacanth gum, karaya gum, and gum arabic, synthetic binders such as polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, and polyvinylpyrrolidone, and inorganic binders such as silica gel, aluminum silica gel, veegum, and laponite. One or more of these may be blended (the amount usually
0.3-5%). Furthermore, in the production of pasty or liquid oral compositions such as toothpaste, sorbitol, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol (#400 to #4000), polypropylene are used as thickening agents. One or more of glycol, xyrite, maltite, lactite, etc. may be blended (the blending amount is usually 10 to 70%). Furthermore, in the present invention, in addition to POE hydrogenated castor oil having an average number of EO added moles of 50 moles or less and an anionic surfactant, other surfactants may be used as necessary, such as fatty acid mono- or diethanolamide such as lauric acid mono- or diethanolamide. , stearyl monoglyceride, sucrose fatty acid esters in which the fatty acid group has 12 to 18 carbon atoms such as sucrose mono- and dilaurate, lactose fatty acid ester, lactitol fatty acid ester, maltitol fatty acid ester, stearic acid monoglyceride, polyoxyethylene sorbitan monolaurate sorbitan monostearate condensate to which approximately 60 moles of ethylene glycol has been added, a polymer of ethylene oxide and propylene oxide, and a nonionic surfactant such as a derivative such as polyoxyethylene polyoxypropylene monolauryl ester; or There is no problem even if two or more types are blended. In this case, POE
(60 moles) Hydrogenated castor oil can also be used as long as it does not impair the effects of the present invention, and the average number of moles of EO added is
More than 60 moles, such as POE (80 moles or
100 mol) hydrogenated castor oil can be used. The oral composition of the present invention further contains sweeteners (from 0 to 1%, preferably 0.01
~0.5%), p-hydroxymethylbenzoitukaside, p-hydroxyethylbenzoitukaside, p-hydroxypropylbenzoitukaside, p-hydroxybutylbenzoitukaside,
Preservatives such as sodium benzoate and lower fatty acid monoglycerides, gelatin, peptone, arginine hydrochloride, albumin, casein, titanium dioxide, and other ingredients may be blended. Furthermore, in the present invention, the active ingredients include enzymes such as dextranase, amylase, protease, mutanase, lysozyme, lytic enzyme, and litetsu enzyme, and alkali metal monomers such as sodium monofluorophosphate and potassium monofluorophosphate. Fluorides such as fluorophosphate, sodium fluoride, and stannous fluoride, tranexamic acid and epsilon aminocaproic acid, chlorhexidine hydrochloride, chlorhexidine gluconate,
Tocopherol, aluminum chlorohydroxyallantoin, dihydrocholesterol, glycyrrhizinic acid, glycyrrhizin dipotassium, glycyrrhetinic acid, glycerophosphate, chlorophyll, sodium copper chlorophyllin, calopeptide, water-soluble inorganic phosphate compound, azulene, chamomile, toki, peony, river 〓 One or more kinds of active ingredients such as crude drugs such as , ginger, and soybeans can be blended. Next, experimental examples will be shown to specifically explain the effects of the present invention. Example 1 Sample solution 50 containing 5% dibasic calcium phosphate dihydrate and the surfactant shown in Table 1 at a predetermined concentration.
Add 0.01g of oil-soluble dye yellowAB per ml,
Stir with chemical stirrer (400 rpm, 1 minute)
After that, the solution was immediately filtered to remove undissolved components, and the absorbance of the solution was measured (layer length: 10 mm, wavelength: 450 nm). The results are shown in Table 1.

[Table] From the results in Table 1, by using POE (40 mol) hydrogenated castor oil together with SDS (anionic activator), these act synergistically and successfully solubilize oil-soluble components. was recognized. Experimental Example 2 A toothpaste with the following formulation was manufactured using the surfactants shown in Table 2.

[Table] Next, the liquid separation and foaming of this toothpaste were evaluated using the following methods. The results are shown in Table 2. Liquid separation After preparing the toothpaste, liquid separation was observed when it was stored at room temperature for one month. ○: No liquid separation △: Slight liquid separation ×: Foaming with liquid separation A sensory evaluation of foaming was performed when the toothpaste was actually used. 〇: Good foaming △: Slightly low foaming ×: Almost no foaming

[Table] From the results in Table 2, liquid separation occurred when POE (60 mol) hydrogenated castor oil was used in combination with SDS (anion activator), but POE (50 mol, 40 mol)
It was found that by using hydrogenated castor oil (mol, 30 mole, 20 mole, and 10 mole) in combination with an anionic activator, a toothpaste with good foaming properties without causing liquid separation could be obtained. Experimental Example 3 A sodium chloride-containing toothpaste having the following formulation was produced, and the presence or absence of liquid separation was evaluated in the same manner as in Experimental Example 2. The results are shown in Table 3. Calcium carbonate 40.0% Anhydrous silicic acid 2.0 Propylene glycol 2.0 Sorbit 16.0 Sodium carboxymethyl cellulose 1.2 Sodium satucalin 0.1 SDS 1.5 POE hydrogenated castor oil 0.5 Sodium chloride 5.0 Paraben 0.1 Fragrance 1.0 Purified water Balance 100.0

[Table] From the results in Table 3, POE (50 mol, 40 mol,
It was found that no liquid separation occurred when hydrogenated castor oil (30 mol, 20 mol, and 10 mol) was used. Experimental Example 4 In the toothpaste manufactured in Experimental Example 3,
The same formulation was used, except that 1.5% sodium α-olefin sulfonate having 14 carbon atoms was added instead of SDS, and POE hydrogenated castor oils with average EO addition moles of 60 mol, 40 mol, and 20 mol were used. A toothpaste was produced, and the presence or absence of liquid separation was evaluated in the same manner as in Experimental Example 2. The results are shown in Table 4.

[Table] From the results in Table 4, it was confirmed that liquid separation did not occur when POE (20 mol or 40 mol) hydrogenated castor oil and α-olefin sulfonate were used together. Experimental Example 5 A toothpaste containing sodium chloride with the following formulation was manufactured and its usability was evaluated. Calcium carbonate 40.0% Propylene glycol 2.0 Sorbitto 16.0 Sodium carboxymethyl cellulose 1.2 Sodium saccharin 0.05 SDS 2.0 POE hydrogenated castor oil 0.5 Sodium chloride 10.0 Paraben 0.1 Fragrance 1.0 Purified water Balance 100.0% Average number of moles of EO added as POE hydrogenated castor oil 60
moles and 50 moles, 40 moles, 30 moles, 20 moles,
Table 5 shows the results of a paired comparison test conducted by 10 expert panelists on toothpastes using 10 mol of each.

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[Table] From the results in Table 5-1 to 5, POE (50 mol,
Toothpaste using hydrogenated castor oil (40 mol, 30 mol, 20 mol, and 10 mol) has a much better aftertaste than toothpaste using hydrogenated castor oil (POE (60 mol)), has a faster foaming speed, and has a pleasant feeling of use. Recognized as excellent. From the results in Table 4, the toothpaste using POE (40 mol) hydrogenated castor oil has a much better aftertaste than the toothpaste using POE (60 mol) hydrogenated castor oil, has a faster foaming speed, and has a better feeling of use. Recognized as excellent. In addition, the results of a pairwise comparison test of toothpaste A using POE hydrogenated castor oil with an average number of moles of EO addition of 20 moles (toothpaste C) and toothpaste A also revealed that toothpaste C had a good aftertaste and a good feeling of use. It was excellent. Experimental Example 6 The toothpaste of Experimental Example 4 was filled into a laminated tube and stored at -5°C for one month, and then the ease of extrusion from the tube was sensory-evaluated at -5°C. The results are shown in Table 6. Evaluation criteria 〇: Extrudes smoothly △: Requires a little force to extrude ×: Requires a lot of force to extrude

[Table] From the results in Table 6, POE (50 mol, 40 mol,
It has been found that extrudability at low temperatures can be improved by using hydrogenated castor oil (30 mol, 20 mol and 10 mol). Examples are shown below. Examples 1 Calcium 2 phosphate 45.0 % hydrogy acid 2.0 Sorbitzo 18.0 Calvoxymethylcerous sodium 1.2 laurelil sodium sodium sodium sodium sodium 1.5 PoE (40 moles) hardened hemi oil 0.5 5 コ 酸 酸 酸 酸 酸 酸 酸 酸 0 0 0 0 0 0 0 0 0 0 0 Karin sodium 0.15 fragrance (peppermint system) 1.0 paraben 0.1 Purified water Balance total 100.0% Example 2 Toothpaste calcium carbonate 40.0% Sorbit 10.0 Glycerin 10.0 Sodium carboxymethylcellulose 0.5 Carrageenan 0.5 Sodium lauryl sulfate 1.5 POE (30 mol) Hydrogenated castor oil 1.0 Sodium monofluorophosphate 0.76 Sodium saccharin 0.2 Fragrance (Spearmint type) 1.0 Paraben 0.1 Purified water Balance 100.0% Example 3 Toothpaste aluminum hydroxide 50.0% Silicic anhydride 2.0 Sorbiturate 16.0 Propylene glycol 2.0 Sodium carboxymethyl cellulose 1.0 Sodium α-olefin sulfonate 2.0 POE (20 mol) hardening Castor oil 0.8 Glycyrrhetinic acid 0.03 Tranexamic acid 0.05 Satucalin sodium 0.2 Fragrance (spearmint type) 1.2 Paraben 0.15 Purified water Balance total 100.0% Example 4 Toothpaste calcium carbonate 35.0% Silicic anhydride 1.5 Sorbit 16.0 Propylene glycol 2.0 Carboxymethyl Cellulose Sodium 1.2 Lauryl Sodium sulfate 2.0 POE (40 mol) Hydrogenated castor oil 1.0 Sodium chloride 10.0 Allantoin chlorhydroxyaluminum
0.1 ε -aminocoproponic acid 0.03 Satsukarin sodium 0.05 fragrance (double mint system) 1.0 paraben 0.05 Refined water remaining 100.0 % metropolitan 1.0 % of denture Calvoxymethylcellulose natrium 0.6 Carrageenan 0.5 Sodium lauryl sulfate 1.0 POE (40 mol) Hydrogenated castor oil 0.5 Lauroyl sarcosinate 0.5 Glycyrrhizin dipotassium 0.1 Fragrance (peppermint type) 1.0 Paraben 0.2 Purified water Balance 100.0% Example 6 Toothpaste aluminum hydroxide 45.0% Sorbit 16.0 Propylene glycol 2.0 Sodium carboxymethyl cellulose 1.2 Sodium lauryl sulfate 1.8 POE (20 mol) Hydrogenated castor oil 0.3% Sodium satucalin 0.2 Fragrance (peppermint type) 1.2 Paraben 0.1 Purified water Balance 100.0% Example 7 Precipitated toothpaste silica 25.0% Sorbit 10.0 Glycerin 20.0 Sodium carboxymethyl cellulose 1.0 Sodium lauryl sulfate 1.5 POE (20 mol) Hydrogenated castor oil 0.5 Chlorhexidine gluconate 0.01 Sodium monofluorophosphate 0.76 Sodium saccharin 0.1 Flavor (peppermint type) 1.0 Purified water Remaining amount 100.0% Example 8 Toothpaste dicalcium phosphate 40.0% Silicic anhydride 2.0 Sorbit 16.0 Propylene glycol 2.0 Sodium carboxymethyl cellulose 1.2 Sodium lauryl sulfate 2.0 POE (40 mol) Hydrogenated castor oil 0.5 Sodium chloride 10.0 Tranexamic acid 0.05 Tocopheryl acetate 0.2 Saccharin sodium 0.05 Fragrance (spare) Mint type) 1.0 paraben 0.05 purified water surplus 100.0 % 100.0 % calcium carbonate 35.0 % sorbitzo 2.0 % sorbit 10.0 % sorbit 10.0 % glycirin 6.0 carboximethylcellulose natrium 0.8 Calaginan 0.4 laurelil sodium 1.5 Laurelicocarcocarcean Tate 0.5 PoE (20 mol) hard -cured castor oil 1.0 Sodium chloride 5.0 Glycyrrhizin dipotassium 0.05 Sodium glutamate 0.001 Fragrance (double mint type) 1.0 Paraben 0.05 Purified water Balance total 100.0% Example 10 Toothpaste Aluminum hydroxide 40.0% Sorbit 16.0 Propylene glycol 2.0 Sodium carboxymethyl cellulose 1.0 Sodium alginate 0.2% lauryl sulfate Sodium 2.5 POE (40 mol) Hydrogenated castor oil 1.0 Sodium chloride 15.0 ε-Aminocaproic acid 0.03 Saccharin sodium 0.05 Fragrance 1.0 Paraben 0.1 Purified water Balance 100.0% Example 11 Toothpaste calcium carbonate 45.0% Sorbit 16.0 Propylene glycol 2.0 Carboxymethyl cellulose Sodium 1.2 Sodium α-olefin sulfonate 2.0 POE (20 mol) Hydrogenated castor oil 0.3 Sodium chloride 10.0 Glycyrrhetinic acid 0.02 Sodium saccharin 0.05% Fragrance 1.0 Paraben 0.1 Purified water Balance 100.0% Example 12 Toothpaste dibasic calcium phosphate 35.0 % Sorbit 8.0 Glycerin 8.0 Sodium carboxymethylcellulose 1.2 Sodium lauryl sulfate 2.0 POE (40 mol) hydrogenated castor oil 1.5 Sodium chloride 20.0 Allantoin chlorhydroxyaluminum
0.1 Sodium inosinate 0.001 Sodium guanylate 0.001 Sodium saccharin 0.1 Fragrance 1.0 Paraben 0.05 Lauric diethanolic acid 0.5% Purified water Balance 100.0% Example 13 Toothpaste calcium carbonate 35.0% Silicic anhydride 2.0 Sorbit 16.0 Propylene glycol 2.0 carboxymethylcellulose Sodium 1.2 Sodium lauryl sulfate 1.8 POE (40 mol) hydrogenated castor oil 0.5 Sodium chloride 10.0 Tranexamic acid 0.05 Allantoin chlorohydroxyaluminum
0.1 Satucharin sodium 0.1 Fragrance 1.0 Paraben 0.05 Purified water Balance total 100.0% All of the toothpastes of Examples 1 to 13 have a good feeling of use, are resistant to liquid separation, and have excellent low-temperature extrudability.

Claims (1)

[Claims] 1. The average number of moles of ethylene oxide added is 50 moles,
At least one selected from 40 mol, 30 mol, 20 mol and 10 mol polyoxyethylene hydrogenated castor oil
The composition contains a water-soluble salt of a higher alkyl sulfate having an alkyl group of 8 to 18 carbon atoms and/or a water-soluble salt of α-olefin sulfonic acid. Total 0.5~
An oral cavity composition characterized by containing 5% by weight. 2 The average number of moles of ethylene oxide added is 50 moles,
At least one selected from 40 mol, 30 mol, 20 mol and 10 mol polyoxyethylene hydrogenated castor oil
The composition contains a water-soluble salt of a higher alkyl sulfate having an alkyl group of 8 to 18 carbon atoms and/or a water-soluble salt of α-olefin sulfonic acid. Total 0.5~
An oral composition comprising 5% by weight of sodium chloride. 3 The amount of sodium chloride in the entire composition is 3~
30% by weight of the oral composition according to claim 2.