JPS6217967B2 - - Google Patents

Description

[Detailed description of the invention]

In the present invention, the average number of moles of ethylene oxide added is
The present invention relates to an oral composition comprising 80 moles and/or 100 moles of polyoxyethylene hydrogenated castor oil in combination with an anionic activator. Oral compositions such as toothpaste usually contain an anionic active agent such as sodium lauryl sulfate as a foaming agent, which also functions as a dispersant for fragrances and the like. However, using only an anionic activator such as sodium lauryl sulfate has little ability to solubilize perfumes, particularly low polarity perfume components and oil-soluble components. In other words, many fragrances are lipophilic, and especially hydrocarbon components contained in natural essential oils are weakly hydrophilic.
It is difficult to sufficiently dissolve and disperse these fragrances using only anionic activators. For this reason, peppermint oil and spearmint oil, which have traditionally been widely used as flavoring agents in oral compositions, contain a large amount of monoterpenes that are poorly soluble in water, and when used in large amounts, they can be solubilized only by the anionic activator. Since it is difficult to do this and there is a limit to the amount of menthol that can be used, comparatively hydrophilic menthol and carvone are added as supplements to prevent the flavor from deteriorating. Also,
Likewise, oil-soluble components such as pigments and oil-soluble vitamins cannot be sufficiently dissolved and dispersed using anionic activators alone. Therefore, in order to facilitate the dispersion and solubilization of these fragrances and oil-soluble components, it is desirable to further enhance the solubilizing power of oral compositions. In addition, from the viewpoint of commercial value, oral compositions such as toothpaste must have high storage stability and must not cause liquid separation during storage, and oral compositions must not be used in the oral cavity. Therefore, it is desirable that the usability is good. In view of the above circumstances, the present inventors have made efforts to develop an oral composition that has excellent ability to disperse and solubilize fragrances and oil-soluble ingredients, has good storage stability, is resistant to liquid separation, and is comfortable to use. As a result of research,
The average number of moles of ethylene oxide added is 80 moles and/or
or polyoxyethylene hydrogenated castor oil in an amount of 0.1 to 3% by weight of the entire composition, and a water-soluble salt of a higher alkyl sulfate having an alkyl group of 8 to 18 carbon atoms and/or α-olefin sulfonic acid as an anion activator. It has been found that the above object can be effectively achieved when a water-soluble salt of 0.5 to 5% by weight of the total composition is used in combination. That is, conventionally, polyoxyethylene hydrogenated castor oil (hereinafter referred to as POE (60 moles) hydrogenated castor oil) with an average number of moles of ethylene oxide added of 60 moles is used in combination with anionic activators such as acylamino acids and sodium lauryl sulfate. In addition, it is known that sodium chloride is added to this (Japanese Patent Publication No. 55-6611, JP-A No. 54-20142, 54-
59340, 56-113709, 57-106606). However, according to the results of the study by the present inventors, POE (60 mol)
Oral compositions containing hydrogenated castor oil in combination with an anionic activator tend to cause liquid separation, and especially in systems that do not contain sodium chloride, the liquid separation is so severe that they are unusable and reduce the product price. Furthermore, when POE (60 mol) hydrogenated castor oil was used in combination with an anionic activator, especially in the case of a sodium chloride compounded system, the feeling of use was poor, and especially the foaming was insufficient. However, polyoxyethylene (POE) hydrogenated castor oil with an average number of moles of ethylene oxide (EO) added of 80 moles or 100 moles is used in an amount of 0.1 to 3% by weight of the entire composition, and higher alkyl sulfuric acid with an alkyl group having 8 to 18 carbon atoms is used. The water-soluble salt of ester and/or the water-soluble salt of α-olefin sulfonic acid is added in an amount of 0.5 to 0.5% of the total composition.
When used in combination with 5% by weight, the disadvantages that occur when using POE (60 mol) hydrogenated castor oil as mentioned above are surprisingly solved, liquid separation is difficult to occur, foaming is very good, and the feeling of use is good. The inventors have discovered that it is possible to obtain an oral composition that has excellent dispersibility of fragrances and oil-soluble components, and has led to the present invention. The present invention will be explained in more detail below. The oral composition according to the present invention has an average number of added moles of ethylene oxide (EO) of 80 moles and/or 100 moles.
Contains 0.1 to 3% by weight of the entire composition of polyoxyethylene (POE) hydrogenated castor oil, and also contains higher alkyl sulfate esters having alkyl groups of 8 to 18 carbon atoms, such as sodium lauryl sulfate and sodium myristyl sulfate. water-soluble salt and/or α-
The composition contains a water-soluble salt (for example, sodium salt) of olefin sulfonic acid in an amount of 0.5 to 5% by weight based on the total composition. In addition, in the present invention, if necessary, other anion activators may be used, such as water-soluble higher fatty acid monoglyceride sulfonates whose fatty acid group has 10 to 18 carbon atoms, such as sodium lauryl monoglyceride sulfonate and sodium coconut monoglyceride sulfonate. salt, higher fatty acid sodium monoglyceride monosulfate, sodium-N
-Methyl-N-palmitoyl tauride, sodium-N-lauroyl sarcosinate, sodium-
A salt of an amide of a higher fatty acid having a fatty acid group having 12 to 18 carbon atoms such as N-lauroyl-β-alanine and a lower aliphatic amino acid may also be blended. The oral composition of the present invention has EO as described above.
By using POE hydrogenated castor oil with an added mole of 80 moles and/or 100 moles in combination with an anionic activator, liquid separation is difficult to occur, and even in systems that do not contain sodium chloride, POE (60 moles) ) It does not have the disadvantage of significant liquid separation that occurs when hydrogenated castor oil is used, and is therefore suitable for use in systems that do not contain sodium chloride. There is no problem even when sodium is added, and even when used in a system containing sodium chloride, it foams very well and has an excellent feeling of use, so it is also suitable for use in systems containing sodium chloride. . In addition, when blending sodium chloride, the blending amount is preferably 3 to 30% of the total composition. If the amount is less than 3%, the benefits of adding sodium chloride will not be fully exhibited, and in particular, the salty taste will not be imparted sufficiently. Moreover, if it is more than 30%, the usability may deteriorate. In addition, the oral composition of the present invention uses POE hydrogenated castor oil with an average EO addition mole number of 80 moles and/or 100 moles in combination with an anionic activator, thereby improving the dispersibility of fragrances and oil-soluble components. For this reason, fragrances, especially those containing a large amount of monoterpenes such as peppermint oil and spearmint oil, and lipophilic fragrances can be used in large quantities by increasing their solubilizing and dispersing power. Oil-soluble components can also be blended with good dispersibility. Incidentally, examples of fragrances suitably used in the present invention include peppermint oil, spearmint oil, menthol, carvone, anethole, eugenol, methyl salicylate, limonene, ocimene, n-desicyl alcohol, citronellol,
α-terpineol, methyl acetate, citronellyl acetate, methyl eugenol, cineole, linalool, ethyl linalool, vanillin, thymol, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, Examples include wintergreen oil, clove oil, eucalyptus oil, etc. In the present invention, these fragrances alone or in combination account for 0.1 to 10% of the total, preferably 0.5 to 5%.
% can be blended. The oral composition of the present invention is applied as a dentifrice such as a toothpaste, and in the present invention, appropriate commonly used ingredients may be further blended depending on the type of the oral composition. . For example, in the case of toothpaste, dibasic calcium phosphate dihydrate and anhydride, dibasic calcium phosphate, dibasic calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, silicic anhydride, silica gel, aluminum silicate , insoluble sodium metaphosphate, tertiary magnesium phosphate, magnesium carbonate, calcium sulfate, polymethyl methacrylate, bentonite, zirconium silicate, synthetic resin, etc. (the amount usually ranges from 20% to 60%). In addition, in the case of paste compositions such as toothpaste, cellulose derivatives such as carrageenan, sodium carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, sodium carboxymethylhydroxyethylcellulose, and alkali metal alginates such as sodium alginate are used as binders. , alginate propylene glycol ester,
Gums such as xanthan gum, tragacanth gum, karaya gum, gum arabic, synthetic binders such as polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, inorganic binders such as silica gel, aluminum silica gel, vegum, laponite, etc. species or two or more species may be blended (the amount usually
0.3-5%). Furthermore, in the production of pasty or liquid oral compositions such as toothpaste, sorbitol, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol (#400 to #4000), polypropylene are used as thickening agents. One or more of glycol, xyrite, maltite, lactite, etc. may be blended (the blending amount is usually 10 to 70%). Furthermore, in the present invention, in addition to POE hydrogenated castor oil having an average EO addition mole number of 80 moles or more and an anionic surfactant, other surfactants may be used as necessary, such as fatty acid mono- or diethanolamide such as lauric acid mono- or diethanolamide. , stearyl monoglyceride, sucrose fatty acid esters in which the fatty acid group has 12 to 18 carbon atoms such as sucrose mono- and dilaurate, lactose fatty acid ester, lactitol fatty acid ester, maltitol fatty acid ester, stearic acid monoglyceride, polyoxyethylene sorbitan monolaurate sorbitan monostearate condensate to which approximately 60 moles of ethylene glycol has been added, a polymer of ethylene oxide and propylene oxide, and a nonionic surfactant such as a derivative such as polyoxyethylene polyoxypropylene monolauryl ester; or There is no problem even if two or more types are blended. In this case, POE
(60 mol) Hydrogenated castor oil can also be used within the range that does not impair the effects of the present invention, and in addition, those with less than 50 mol of EO added, such as POE (20 mol or 40 mol)
mol) Hydrogenated castor oil can be used. In addition, when POE (20 mol or 40 mol) hydrogenated castor oil is used in combination with the activator of the present invention, the aftertaste is further improved, the feeling of use is further improved, and the low-temperature extrudability is improved, so its use is prohibited. This is preferable. The oral composition of the present invention further contains sweeteners (from 0 to 1%, preferably 0.01
~0.5%), p-hydroxymethylbenzoitukaside, p-hydroxyethylbenzoitukaside, p-hydroxypropylbenzoitukaside, p-hydroxybutylbenzoitukacid,
Preservatives such as sodium benzoate and lower fatty acid monoglycerides, gelatin, peptone, arginine hydrochloride, albumin, casein, titanium dioxide, and other ingredients may be blended. Furthermore, in the present invention, the active ingredients include enzymes such as dextranase, amylase, protease, mutanase, lysozyme, lytic enzyme, and lytic enzyme, and alkali metal monomers such as sodium monofluorophosphate and potassium monofluorophosphate. Fluorides such as fluorophosphate, sodium fluoride, and stannous fluoride, tranexamic acid and epsilon aminocaproic acid, chlorhexidine hydrochloride, chlorhexidine gluconate,
Tocopherol, aluminum chlorohydroxyallantoin, dihydrocholesterol, glycyrrhizic acid, dipotassium glycyrrhizin, glycyrrhetinic acid, glycerophosphate, chlorophyll, sodium copper chlorophyllin, calopeptide, water-soluble inorganic phosphate compound, azulene, chamomile, toki, peonies, river peonies One or more kinds of active ingredients such as crude drugs such as , ginger, and soybeans can be blended. Next, experimental examples will be shown to specifically explain the effects of the present invention. Experimental example 1 Sample solution 50 containing 5% dicalcium phosphate dihydrate and the surfactant shown in Table 1 at a predetermined concentration.
Add 0.01g of oil-soluble dye yellow AB per ml,
Stir with chemical stirrer (400 rpm, 1 minute)
Immediately after that, undissolved matter was removed by filtering, and the absorbance of the liquid was measured (layer length: 10 mm, wavelength: 450 nm). The results are shown in Table 1.

[Table] From the results in Table 1, by using POE (80 mol) hydrogenated castor oil together with SDS (anionic activator), these act synergistically and successfully solubilize oil-soluble components. was recognized. Experimental Example 2 A toothpaste with the following formulation was manufactured using the surfactants shown in Table 2. Dibasic calcium phosphate 45.0% Propylene glycol 2.0 Sorbit 8.0 Glycerin 8.0 Sodium carboxymethyl cellulose 1.1 Sodium saccharin 0.1 Parapen 0.1 Flavor Menthol 0.2 Peppermint oil 0.5 Others 0.3 Surfactant Amount shown in Table 2 Purified water Remaining 100.0% Next, use this toothpaste Liquid separation and foaming were evaluated by the following methods. The results are shown in Table 2. Liquid Separation After preparing the toothpaste, liquid separation was observed when it was stored at room temperature for one month. ○: No liquid separation △: Slight liquid separation ×: Foaming with liquid separation A sensory evaluation of foaming was performed when the toothpaste was actually used. 〇: Good foaming △: Slightly low foaming ×: Almost no foaming

[Table] From the results in Table 2, liquid separation occurred when POE (60 mol) hydrogenated castor oil was used in combination with SDS (anion activator), but POE (80 mol or
It was found that by using hydrogenated castor oil (100 mol) in combination with an anionic activator, a toothpaste with good foaming and no liquid separation could be obtained. Experimental Example 3 A sodium chloride-containing toothpaste having the following formulation was produced, and the presence or absence of liquid separation was evaluated in the same manner as in Experimental Example 2. The results are shown in Table 3. Calcium carbonate 40.0% Anhydrous silicic acid 2.0 Propylene glycol 2.0 Sorbit 16.0 Sodium carboxymethyl cellulose 1.2 Sodium saccharin 0.1 SDS 1.5 POE hydrogenated castor oil 0.5 Sodium chloride 5.0 Paraben 0.1 Fragrance 1.0 Purified water Balance 100.0

[Table] From the results in Table 3, it was confirmed that liquid separation did not occur when POE (80 mol or 100 mol) hydrogenated castor oil was used. Experimental Example 4 An aqueous solution containing 1% SDS or sodium α-olefin sulfonate (ADS) of carbon 14, 1% POE hydrogenated castor oil shown in Table 4, and 15% sodium chloride was prepared and used as a sample. 10 ml of this sample was placed in a 100 ml colorimetric tube, shaken vigorously 30 times, and left to stand for 1 minute after shaking to measure the amount of foam. The results are shown in Table 4.

[Table] From the results in Table 4, SDS or AOS and POE (80
It was observed that the foaming amount was large and the foaming was good when using hydrogenated castor oil (mol or 100 mol). Experimental Example 5 A sodium chloride-containing toothpaste having the following formulation was manufactured, and its usability was evaluated. Calcium carbonate 40.0% Propylene glycol 2.0 Sorbit 16.0 Sodium carboxymethylcellulose 1.2 Sodium saccharin 0.05 SDS 2.0 POE hydrogenated castor oil 0.5 Sodium chloride 10.0 Paraben 0.1 Fragrance 1.0 Purified water Remaining 100.0% Average number of moles of EO added as POE hydrogenated castor oil 60
Table 5 shows the results of a paired comparison test conducted by a panel of 10 experts on toothpastes using mol and 80 mol toothpastes, respectively.

[Table] From the results in Table 5, the toothpaste using POE (80 mol) hydrogenated castor oil has a much higher foaming amount and has a better feel than the toothpaste using POE (60 mol) hydrogenated castor oil. It was recognized that there was. In addition, the results of a pairwise comparison test of toothpaste A using a POE hydrogenated castor oil with an average number of moles of EO added of 100 moles (toothpaste C) and the above toothpaste A also showed that toothpaste C had good foaming properties and felt good when used. was excellent. Furthermore, as POE hydrogenated castor oil, the average EO
Even when using a mixture of 80 moles and 100 moles added at a ratio of 1:1 (weight ratio), the effect is equivalent to that of using 80 moles or 100 moles alone. Obtained. Examples are shown below. Example 1 Toothpaste Calcium carbonate 40.0% Sorbit 10.0 Glycerin 10.0 Sodium carboxymethyl cellulose 0.5 Carrageenan 0.5 Sodium lauryl sulfate 1.5 POE (100 mol) Hydrogenated castor oil 1.0 Sodium monofluorophosphate 0.76 Sodium saccharin 0.2 Fragrance (spearmint type) 1.0 Paraben 0.1 Purified water Balance 100.0% Example 2 Toothpaste calcium carbonate 35.0% Silicic anhydride 1.5 Sorbiturate 16.0 Propylene glycol 2.0 Sodium carboxymethyl cellulose 1.2 Sodium lauryl sulfate 2.0 POE (80 mol) Hydrogenated castor oil 1.0 Sodium chloride 10.0 Allantoin chlorohydroxy aluminum 0.1 ε -Aminocaproic acid 0.03 Satucharin sodium 0.05 Flavor (peppermint type) 1.0 Paraben 0.05 Purified water Balance 100.0% Example 3 Toothpaste aluminum hydroxide 45.0% Sorbit 16.0 Propylene glycol 2.0 Sodium carboxymethyl cellulose 1.2 Sodium lauryl sulfate 1.8 POE (80 mol) Hydrogenated castor oil 0.3 Satucharin sodium 0.2 Fragrance (double mint type) 1.2 Paraben 0.1 Purified water Balance 100.0% Example 4 Toothpaste aluminum hydroxide 40.0% Sorbit 10.0 Glycerin 6.0 Sodium carboxymethylcellulose 1.2 Sodium lauryl sulfate 2.0 POE (80 mol) Hydrogenated castor oil 1.0 Sodium chloride 10.0 ε-aminocaproic acid 0.03 Tocopherol acetate 0.2 Saccharin sodium 0.05 Fragrance 1.0 Paraben 0.1 Purified water Balance 100.0% Example 5 Toothpaste calcium carbonate 35.0% Silicic anhydride 1.5 Sorbit 16.0 Propylene glycol 2.0 Carbo Sodium oxymethylcellulose 0.6 Karaginan 0.5 Lauril sodium sodium sodium sulfate 2.3 lauric acid dipo -amide 0.5 PoE (100 mol) hardened pine oil 0.5 sodium chloride 0.0 tranexamic acid 0.05 Satsukarin sodium 0.05 fragrance 1.0 paraben 0.0 paraben 0.0 % 6 Calcium phosphate 40.0 denture 2 phosphate % Sorbit 20.0 Propylene glycol 2.0 Sodium carboxymethylcellulose 1.2 Sodium lauryl sulfate 1.5 Lauroyl sarcosinate 0.5 POE (80 mol) hydrogenated castor oil 0.3 Sodium chloride 5.0 Allantoin chlorhydroxyaluminum 0.1 Sodium satucalin 0.05 Sodium inosinate 0.001 Fragrance 1.0 Paraben 0. 1 purification Water remaining 100.0% Example 7 Toothpaste dicalcium phosphate 35.0% Silicic anhydride 1.5 Sorbit 8.0 Glycerin 8.0 Sodium carboxymethyl cellulose 1.0 Carrageenan 0.2 Sodium lauryl sulfate 1.8 POE (100 mol) Hydrogenated castor oil 0.8 Sodium chloride 15.0 ε-Aminocaproic acid 0.03 Glycyl Litin Dipotassium 0.1 Satucharin sodium 0.05 Sodium glutamate 0.001 Fragrance 1.0 Paraben 0.1 Purified water Remaining 100.0% Example 8 Toothpaste calcium carbonate 45.0% Sorbit 16.0 Propylene glycol 2.0 Sodium carboxymethyl cellulose 1.2 Sodium α-olefin sulfonate 1.5 POE (80 mol) Hydrogenated castor oil 1.0 Sodium chloride 10.0 Tranexamic acid 0.05 Glycyrrhizin dipotassium 0.1 Satucalin sodium 0.05 Fragrance 1.0 Paraben 0.1 Purified water Balance 100.0% Example 9 Toothpaste aluminum hydroxide 35.0% Silicic anhydride 1.5 Sorbit 10.0 Glycerin 8.0 Carbo Sodium oxymethylcellulose 1.0 Lauryl Sodium sulfate 2.5 POE (100 mol) hydrogenated castor oil 1.5 Sodium chloride 20.0 Glycyrrhizic acid 0.02 Tocopherol acetate 0.2 Sodium saccharin 0.05 Sodium guanylate 0.001 Fragrance 1.0 Paraben 0.1 Purified water Remaining 100.0% All toothpastes of Examples 1 to 9 It foams well, feels good when used, and is resistant to liquid separation.

Claims (1)

[Scope of Claims] 1 Contains 0.1 to 3% by weight of the entire composition of polyoxyethylene hydrogenated castor oil with an average number of added moles of ethylene oxide of 80 moles and/or 100 moles, and an alkyl group having 8 to 8 carbon atoms. The water-soluble salt of 18 higher alkyl sulfates and/or the water-soluble salt of α-olefin sulfonic acid is added to 0.5 of the total composition.
An oral cavity composition characterized by containing ~5% by weight. 2 Contains 0.1 to 3% by weight of the entire composition of polyoxyethylene hydrogenated castor oil with an average number of added moles of ethylene oxide of 80 moles and/or 100 moles, and a higher alkyl sulfate ester having an alkyl group with a carbon number of 8 to 18. and/or a water-soluble salt of α-olefin sulfonic acid in an amount of 0.5 of the total composition.
1. An oral cavity composition containing up to 5% by weight of sodium chloride. 3 The amount of sodium chloride in the entire composition is 3~
30% by weight of the oral composition according to claim 2.