JPS6317310B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a powder aerosol composition,
Conventionally, aerosol products in which a powder is suspended in liquefied chlorofluorocarbon gas along with a main agent and an auxiliary agent and sprayed are known as antiperspirants, athlete's foot medicines, dry shampoos, baby powders, and the like. However, these conventional products have strong scattering properties and have a low rate of adhesion to the skin, and liquefied fluorocarbon gas tends to aggregate when hydrophobic powder is suspended, making it difficult to mix it in a large proportion with fluorocarbon gas. Powder and dispersant can only be filled in an amount of about 0.5 to 10 wt% of the total amount, and liquefied fluorocarbon gas must be used in an amount of 80 wt% or more of the total amount, making it extremely uneconomical. Furthermore, since conventional products use liquefied fluorocarbon gas as a propellant, the propellant is expensive, increasing the price of the product, and has a cooling effect, which can cause frostbite, inflammation, etc. on the skin. Studies have also been published that show that air pollution caused by fluorocarbon gas is undesirable. The present invention relates to a powder aerosol composition which eliminates the above-mentioned drawbacks, and which enables inexpensive production and minimizes the cold sensation and inflammation of the skin.
It also improves safety in use, prevents scattering, and provides good drying properties when applied to the skin, thereby preventing stickiness or the like.
Generally, when powder, water, alcohol, liquefied gas, etc. are mixed, even if a suspension is formed, it becomes highly concentrated and condenses, and redispersibility is poor, making it difficult to eject satisfactorily as an aerosol composition. This tends to cause nozzle clogging, etc. The present invention makes it possible to obtain a satisfactory composition free from the above-mentioned drawbacks by using water, alcohol, powder, water-soluble 1-chloro-1,1-difluoroethane and/or liquefied gas containing 1,1-difluoroethane. It is something. First, the powder is a hydrophobic powder with a pH of 5 to 9.
Use with a particle size of 325 mesh. Talc, celite, kaolin, red iron, rice starch, bentonite, aluminum stearate, etc. can be used as the hydrophobic powder, and if the powder is outside the pH range of 5 to 9, acid treatment is performed to improve the pH range of 5 to 9. It is also possible to use it as an internal item. This PH5~
If a hydrophobic powder outside the range of 9 is used as it is, it will aggregate in the aerosol container and clog the valve, making it undesirable as an aerosol dosage form. Even with hydrophobic powders outside the pH range of 5 to 9, a stable suspension can be obtained by using a surfactant, but this is not preferable because it foams during injection, giving a poor feeling of use. When the target drug is a powder, it may be hydrophilic if the amount is small. The alcohol has 1 to 7 carbon atoms, and 95 ethyl alcohol, isopropyl alcohol, etc. can be used. It is formed by suspending emollients, disinfectants, target drugs, etc. in these. As propellants, liquefied petroleum gas, dimethyl ether, etc., water-soluble 1-chloro-1,1-difluoroethane and/or
1.1-Difluoroethane is mixed and formed. The formation of this suspension begins with a hydrophobic powder with a pH of 5 to 9.
0.5 to 60 wt% of those in the range of 70 to 325 meshes, preferably 20 to 30 wt%, alcohols with 1 to 7 carbon atoms 5 to 80 wt%, preferably 25 to 35 wt%, water 5 to 80 wt%
% preferably 30-40wt% and emollient,
Appropriate amounts of bactericide and target drug are added and suspended in a homomixer. In this case, the viscosity of the suspension is
The viscosity is 20 CPS to 1000 CPS, and when suspension is carried out at the above preferred blending ratio, the viscosity is 50 CPS to 1000 CPS.
400CPS, and the pH is also formed in the range of 5.5 to 7.5. This suspension is mixed with water and soluble 1-
It is formed by suspending chloro-1,1-difluoroethane and/or 1,1-difluoroethane with a mixed propellant. As described above, the present invention uses a mixture of liquefied petroleum gas, dimethyl ether, etc., and one or both of water-soluble 1-chloro-1,1-difluoroethane and 1,1-difluoroethane as a propellant, so the product can be provided at a low price. In addition, by adding water, flammability can be suppressed even when the propellant is highly flammable. Furthermore, by adding water, the hydrophobic powder absorbs a small amount of water, which improves the adhesion of the powder to the skin and reduces the proportion of scattering, which provides a good feeling of use and is economical. This water also contains water-soluble 1 added to the dosage form.
-Chloro-1,1-difluoroethane, 1,1-difluoroethane, and alcohol are combined, and this combined alcohol and water releases 1-chloro-1,1-difluoroethane and/or 1,1-difluoroethane before it is ejected from the nozzle and reaches the skin. The powder evaporates rapidly as the propellant it contains evaporates, leaving behind only a small amount of moisture for good adhesion, so the powder can be applied to the skin in a dry manner. In addition, since this powder has a pH in the range of 5 to 9, it slightly absorbs alcohol and water in the suspension, has good dispersibility in the suspension, does not aggregate, and is suitable for valves. It does not cause clogging and has good stability during manufacturing and storage. In addition, since no aggregation occurs in the hydrophobic powder, the suspension can be used in a large proportion of the propellant.
The suspension is made from alcohol, water, hydrophobic powder, target drug, etc. to 95 wt% or less, preferably 40 to 75 wt%,
The propellant can be used in an amount of 5 wt% or more, preferably 20 to 30 wt%. The ratio of 1-chloro-1.1-difluoroethane and 1.1-difluoroethane in this propellant is 1-chloro-1.1-difluoroethane and/or 1.1 to 95 to 10 wt% of LPG or DME.
-Difluoroethane can be 10 to 90 wt%. This blending ratio makes it possible to obtain a stable powder aerosol composition. Even when the composition thus obtained is left for a long period of time, precipitation, floating, or condensation of the hydrophobic powder or the target drug is extremely unlikely to occur. Types of hydrophobic powder, target drug, etc.
Depending on the preparation conditions, a slight sedimentation phenomenon may occur, but unlike compositions using conventional liquefied chlorofluorocarbon gas, it does not condense strongly, and can be easily removed by shaking once or twice. It is possible to form a uniform suspension. Example

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[Table] The composition names of the above examples are: Example 1 Powder 〃 2 〃 〃 3 〃 〃 4 〃 〃 5 〃 〃 6 〃 〃 7 〃 〃 8 〃 〃 9 Skin medicine 〃 10 Antiperspirant 〃 11 Skin medicine 〃 12 Antiperspirant 〃 13 Athlete's foot medicine 〃 14 Skin medicine 〃 15 Dry shampoo 〃 16 Antiperspirant 〃 17 Athlete's foot medicine 〃 18 Powder 〃 19 〃 〃 20 〃 〃 21 〃 〃 22 〃 〃 23 〃 〃 24 〃 〃 25 〃 〃 26 Skin medicine 27 Antiperspirant 28 Skin medicine 29 Antiperspirant 30 Athlete's foot medicine 31 Skin medicine 32 Dry shampoo 33 Antiperspirant 34 Athlete's foot medicine 35 Antiperspirant 36 Dry shampoo 37 〃 〃 38 Skin medicine 〃 39 Shoe deodorant 〃 40 Athlete's foot medicine 〃 41 Powder 〃 42 〃 Further, among the above examples, 18 to 42 are examples according to the present invention, and examples 1 to 17 are examples for comparison with the present invention. In addition, the redispersibility in the above examples is
The dispersibility was observed after being left in an atmosphere at 45℃ for 3 months. ◎ indicates uniform dispersion △ indicates a strong tendency to agglomerate × indicates at least partially strong agglomeration are doing.

Claims (1)

[Claims] 1 5-80wt% alcohol having 1-7 carbon atoms, 5-80wt% water, 0.5-60wt% hydrophobic powder with pH 5-9
and an appropriate amount of the target drug to form a suspension, 1-
A powder aerosol composition characterized in that it is formed by suspending 5 to 40 wt% of a propellant containing chloro-1,1-difluoroethane and/or 1,1-difluoroethane.