JPS6317311B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a powder aerosol composition,
Conventional aerosol preparations, which are made by suspending powders together with main ingredients and auxiliary agents in liquefied chlorofluorocarbon gas (dichlorodifluoromethane, trichloromonofluoromethane) and spraying them, are used as antiperspirants, athlete's foot medicine, dry shampoo, baby powder, and sun protection. It is known as a powder, menstrual deodorant, external preparation, etc. However, these conventional products have strong scattering properties and have a low rate of adhesion to the skin, and liquefied chlorofluorocarbon gas has poor redispersibility and tends to aggregate when dichlorodifluoromethane, trichloromonofluoromethane, or hydrophobic powder is suspended. Liquefied Freon gas (F12,
It is difficult to mix large proportions of liquefied chlorofluorocarbon gas (F12, F11) to F11), and the powder and dispersant can only be filled in at a rate of 0.3 to 10 wt% of the total amount. This made it extremely uneconomical. In addition, conventional products use liquefied chlorofluorocarbon gas (F12, F11) as a propellant, which increases the price of the product and causes a cooling sensation when sprayed on the skin, which can also cause frostbite, inflammation, bruising, and rashes. There were cases where it caused pain etc. to the skin. The present invention relates to a powder aerosol composition which eliminates the above-mentioned drawbacks, and which enables inexpensive production and minimizes the cold sensation and inflammation of the skin.
In addition, it improves safety in use, prevents scattering, and improves drying properties when attached to the skin, making it possible to manufacture products with good quality stability without stickiness. . When water, alcohol, liquefied gas, etc. are mixed in powder or dosage form,
Even if a suspension is formed, it becomes highly concentrated and condenses, or forms a gel or sol, regardless of temperature or changes over time, and has poor redispersibility and cannot be spouted satisfactorily as an aerosol composition. This tends to cause clogging of valves, etc. The present invention makes it possible to obtain a satisfactory formulation without the above-mentioned drawbacks using water, alcohol, powder, and liquefied gas.
First, a hydrophobic powder with a pH of 5 to 9 is used as a powder with a particle size of 70 to 325 mesh. Talc for hydrophobic powder,
Celite, kaolin, red iron, rice starch, aluminum stearate, etc. can be used, and those with a pH outside the range of 5 to 9 can be treated with acid, and those with a pH of 5 to 9 can also be used. be. If a hydrophobic powder with a pH outside the range of 5 to 9 is used as it is, it will cause agglomeration, gel, or sol in the aerosol container, clogging the valve or button, which is not preferable as an aerosol dosage form. PH
Even if the hydrophobic powder is outside the range of 5 to 9, a stable suspension can be obtained by using a surfactant, but it may foam during injection or retain viscosity for a long time, giving a poor feeling of use. It is not desirable because it Furthermore, when the target drug is a powder, it may be hydrophilic if the amount is small. Also, alcohol has 1 carbon number
~7, and 95% ethyl alcohol, isopropyl alcohol, etc. can be used. It is formed by suspending emollients, disinfectants, target drugs, etc. in these. In particular, by mixing one or both of 1,1,2 trichlorotrifluoroethane and 1,2 dichlorotetrafluoroethane in the suspension, a good suspension can be obtained, and redispersion is good.
It becomes possible to create a drug with excellent fluidity. In addition, as propellants, compressed gases include carbon dioxide, laughing gas, nitrogen gas, argon gas, etc., and liquefied gases include:
A gas having a specific gravity lighter than the above suspension, such as liquefied petroleum gas or dimethyl ether, may be used alone or in combination. To form this suspension, first, a hydrophobic powder with a pH of 5 to 9 and a particle size in the range of 70 to 325 mesh is prepared.
60 wt%, preferably 5 to 30 wt%, alcohol having 1 to 7 carbon atoms, 5 to 80 wt%, preferably 25 to 35 wt%,
Water 1-80wt% preferably 10-40wt% and 1,
2 dichlorotetrafluoroethane, 1,1,2 trichlorotrifluoroethane or two
~90wt%, preferably 10~70wt%, and appropriate amounts of other emollients, bactericidal agents, and target chemicals are added and suspended in a homomixer. In this case, the viscosity of the suspension is 10 CPS to 1000 CPS, and when suspension is carried out at the above-mentioned preferred blending ratio, the viscosity is 40 CPS.
~400CPS, and PH is also formed in the range of 5.5 to 7.5. This suspension is formed by suspending it in an aerosol container with a propellant consisting of one or more liquefied gases or compressed gases having a lighter specific gravity than the suspension, such as liquefied petroleum gas or dimethyl ether. As mentioned above, the present invention uses liquefied petroleum gas, dimethyl ether, compressed gas, etc. as a propellant, so it can provide products at low cost, and the addition of water suppresses flammability even when the propellant is highly flammable. can. Furthermore, by adding water, the hydrophobic powder absorbs a small amount of water, which improves the adhesion of the powder to the skin and reduces the proportion of scattering, which provides a good feeling of use and is economical. This water also contains the alcohol added to the dosage form,
The water combined with 1,1,2 trichlorotrifluoroethane and/or 1,2 dichlorotetrafluoroethane is a low boiling point substance, 1, by the time it is ejected from the nozzle and reaches the skin. , 1,2 trichlorotrifluoroethane and or 1,2 dichlorotetrafluoroethane;
As the propellant evaporates, it evaporates rapidly, leaving behind only a small amount of moisture for good adhesion, so that the powder can be applied to the skin in a dry manner. Also, since this powder has a pH in the range of 5 to 9, it slightly absorbs alcohol and water in the suspension, and also contains one of 1,1,2 trichlorotrifluoroethane, 1,2 dichlorotetrafluoroethane, or By mixing the two types into a suspension, the redispersibility in the suspension is good, there is no agglomeration, there is no possibility of clogging of valves, etc., and there is no problem during manufacturing, storage, etc. Good stability. In addition, since no agglomeration occurs in the hydrophobic powder, the above suspension can be used in a large proportion to the propellant, and alcohol,
A suspension of water, a hydrophobic powder with a pH of 5 to 9, 1,1,2 trichlorotrifluoroethane, 1,2 dichlorotetrafluoroethane, etc., is made up to 95 wt% or less, preferably 60 to 80 wt%, and a propellant is added. 5wt%
More preferably 15 to 40 wt% can be used,
This blending ratio makes it possible to obtain a powder aerosol composition that is stable, has good texture, and maintains good flexibility. Even when the composition thus obtained is left for a long period of time, precipitation, floating, or condensation of the hydrophobic powder or the target drug is extremely unlikely to occur. Depending on the type of hydrophobic powder, target drug, preparation conditions, etc., a slight sedimentation phenomenon may occur, but unlike compositions using conventional liquefied chlorofluorocarbon gas, it does not condense strongly and A homogeneous suspension can be easily obtained by slightly shaking the suspension. Example

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[Table] The composition names of the above examples are: Example 1 Powder 〃 2 〃 〃 3 Skin medicine 〃 4 Deodorant 〃 5 〃 〃 6 Water medicine 〃 7 〃 〃 8 Antiperspirant 〃 9 〃 〃 10 〃 〃 11 Powder 〃 12 〃 〃 13 Antiperspirant 〃 14 〃 〃 15 〃 〃 16 〃 〃 17 〃 〃 18 〃 〃 19 〃 Examples 20 Antiperspirant 〃 21 Athlete's foot medicine 〃 22 〃 〃 23 〃 〃 24 〃 〃 25 Deolant Powder 26 27 28 29 Dry shampoo 30 31 32 33 Skin medicine 34 Furthermore, among the above Examples, 11 to 34 are examples according to the present invention, and Examples 1 to 10 are examples for comparison with the present invention. In addition, the redispersibility in the above examples is
Dispersibility was observed after being left in an atmosphere at 45°C for 6 months. ◎ indicates uniform dispersion △ indicates strong tendency to agglomerate × indicates at least partial formation of strong aggregates are doing. Fluidity is defined as ◎ when a glass bottle filled with a sample is shaken lightly in an upright position, when the contents move significantly, × when it does not move, and △ when it moves slightly.

Claims (1)

[Claims] 1 5-80wt% alcohol having 1-7 carbon atoms, 5-80wt% water, 0.5-60wt% hydrophobic powder with pH 5-9
%, 1,1,2 trichlorotrifluoroethane and or 1,2 dichlorotetrafluoroethane 5
A powder aerosol composition characterized in that it is formed by forming a suspension at ~90 wt% and suspending a propellant at 5~85 wt% in this suspension.