JPS6320208B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for producing a stretchable transparent adhesive patch, and its purpose is to use a woven or nonwoven fabric as a support by using a polyurethane film as a support. The aim is to improve the shortcomings of conventional patch drugs.

The conventional patch medicine called Hatsuka gum plaster is
A woven or non-woven fabric such as sfumos, flannel, or flannel is used as a support, and a subbing layer is provided by coating a kneaded material such as crude rubber, zinc white, resin, or anti-aging agent on this support. It is manufactured by spreading a homogeneous kneaded material containing a softener, a tackifying resin, a filler, and a base ingredient on a layer. In this case, the softening agent is polybutene, process oil, etc., the tackifying resin is polyterpene resin, linear hydrocarbon resin, hydrogenated rosin ester, etc., and the filler is zinc oxide, titanium dioxide, etc. Each is used individually, and the main ingredients for the plaster include methyl salicylate, glycol salicylate, camphor, l-menthol, capsicum (extract), capsaicin, nonylic acid vanillylamide, adrenal corticosteroids, and skin protectants, which are usually used as a mixture of two or more. has been done.

However, since the support of the conventional patch medicines mentioned above is opaque, it is noticeable when applied to the affected area, and the ability to stretch vertically and horizontally is insufficient, making it difficult to adapt to the movement of the skin. There were some negative effects.

The present invention uses a polyurethane film as a support in place of conventional woven or nonwoven fabrics, thereby attempting to eliminate the above-mentioned drawbacks of conventional patch drugs at once.

Therefore, the method for manufacturing the transparent patch according to the present invention is as follows:
An organic solvent solution of a composition consisting of ~90% by weight of raw rubber and 60-10% by weight of triisocyanate is applied onto a polyurethane film and dried to form an undercoat layer. It consists of applying and spreading a kneaded material containing raw rubber, a softener, a tackifying resin, and a base ingredient for the paste.

When aiming to produce a stretchable transparent patch, it is natural to use a transparent and stretchable plastic film as the support instead of conventional woven or non-woven fabric. By nature, the support must be breathable. Therefore, in the present invention, a polyurethane film that does not contain a plasticizer and whose flexibility hardly changes due to temperature changes is used as a support. However, if a kneaded product containing a paste base ingredient is directly applied and spread on a polyurethane film, the adhesion between the two is insufficient, making it impossible to obtain a satisfactory patch.

According to the present invention, an undercoat layer is formed on the support polyurethane film. The undercoat layer is formed by applying an organic solvent solution of a composition consisting of 40 to 90% by weight of crude rubber and 60 to 10% by weight of triisocyanate onto a polyurethane film and drying it. As the organic solvent in this case, rubber volatile oil, n-hexane, benzene, etc. can be used.

Once the undercoat layer is formed on the polyurethane film in this way, a kneaded material containing a paste base agent is then applied and spread on the undercoat layer to form a drug layer. In the case of the present invention, this kneaded material for forming a drug layer contains polybutene as a softener, polyterpene resin (e.g. ys-resin), linear hydrocarbon resin (e.g. Escorets) and hydrogenated resin as tackifying resins. Rosin esters (e.g. ester gum) etc.
The main ingredients for the plaster include methyl salicylate, glycol salicylate, camphor, l-menthol, capsicum (extract), capsaicin, nonylic acid vanillylamide, adrenal corticosteroids, or skin protective agents, which are usually used in combination. Drug layer constituents conventionally used in the art can also be used in conventional amounts.

Examples will now be presented.

Examples Raw rubber 40~90% by weight, triisocyanate 60~
4.0 g of a 10% by weight composition was dissolved in 40 ml of n-hexane, and this solution was applied to a polyurethane film, dried at 50 to 60°C, and aged to form an undercoat layer on the polyurethane film. Next, a kneaded material containing a plaster base was applied and spread on the undercoat layer to obtain a stretchable transparent patch. A liner such as cellophane, polyethylene film, polypropylene film, or release paper was attached to the surface of the patch.

Each of the patch medicines obtained in this way was subjected to abuse at 80°C for more than 180 hours with the gear open, but no abnormality was observed in terms of efficacy or otherwise.

Claims (1)

[Claims] 1 An organic solvent solution of a composition consisting of 40 to 90% by weight of raw rubber and 60 to 10% by weight of triisocyanate is applied onto a polyurethane film and dried to form an undercoat layer. A method for manufacturing a transparent adhesive patch having elasticity, which comprises applying and spreading a kneaded material containing raw rubber, a softener, a tackifying resin, and a base agent on a pull layer.