JPS6339566B2 - - Google Patents
Info
- Publication number
- JPS6339566B2 JPS6339566B2 JP15460978A JP15460978A JPS6339566B2 JP S6339566 B2 JPS6339566 B2 JP S6339566B2 JP 15460978 A JP15460978 A JP 15460978A JP 15460978 A JP15460978 A JP 15460978A JP S6339566 B2 JPS6339566 B2 JP S6339566B2
- Authority
- JP
- Japan
- Prior art keywords
- coenzyme
- solution
- soft capsules
- manufactured
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 45
- 239000007901 soft capsule Substances 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 15
- 238000011049 filling Methods 0.000 claims description 8
- 230000007935 neutral effect Effects 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 239000004094 surface-active agent Substances 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 4
- 235000017471 coenzyme Q10 Nutrition 0.000 claims description 3
- 239000003921 oil Substances 0.000 description 8
- 235000019198 oils Nutrition 0.000 description 8
- -1 medium-chain fatty acid triglycerides Chemical class 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 4
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 4
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 4
- 229920000053 polysorbate 80 Polymers 0.000 description 4
- 229940035044 sorbitan monolaurate Drugs 0.000 description 4
- 235000011069 sorbitan monooleate Nutrition 0.000 description 4
- 239000001593 sorbitan monooleate Substances 0.000 description 4
- 229940035049 sorbitan monooleate Drugs 0.000 description 4
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 150000004667 medium chain fatty acids Chemical class 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 238000004080 punching Methods 0.000 description 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 3
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 239000005515 coenzyme Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 235000005687 corn oil Nutrition 0.000 description 2
- 239000002285 corn oil Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- FDDZTBYOCCYZRR-UHFFFAOYSA-N 2-[2-(diethylamino)ethyl]-3-phenyl-3h-isoindol-1-one;phosphoric acid Chemical compound OP(O)(O)=O.C12=CC=CC=C2C(=O)N(CCN(CC)CC)C1C1=CC=CC=C1 FDDZTBYOCCYZRR-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 150000002711 medium chain fatty acid esters Chemical class 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920000259 polyoxyethylene lauryl ether Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
本発明は、ソフトカプセル充填用補酵素Q10含
有組成物およびその製法に関する。
補酵素Q10は生体内では電子伝達系に関与して
各種疾病に対して優れた薬理効果を示す物質であ
る。この補酵素Q10を医薬品として提供する場合
に種々の剤型が考えられるが、補酵素Q10の融点
がほぼ50℃と低いために例えば錠剤にした場合に
は打錠時に補酵素Q10が溶融して錠剤の表面に滲
出し商品価値を低下せしめる。また、ハードカプ
セルにした場合にも、賦形剤に吸着された薬物が
保存時に溶融分離するという欠点がある。そこで
本発明者らは、この補酵素Q10をソフトカプセル
化することを試みたが短時間において補酵素Q10
の結晶が析出して溶液の流動性が失われソフトカ
プセル化が不可能となり、あるいはソフトカプセ
ルが製造できたとしても、保存中に補酵素Q10の
結晶が析出して体内における吸収が悪くなるとい
うような欠点があつた。
そこで本発明者らは長期間安定な補酵素Q10の
溶液を得るべく研究を重ねた結果、補酵素Q10を
中性油に溶解するにあたり、界面活性剤を存在せ
しめることによつて長期間安定な溶液が得られる
ことを見出し、本発明を完成するに至つた。
本発明で云う中性油とは大豆油、とうもろこし
油、ピーナツツ油、綿実油等の植物性油、魚肝油
等の動物性油、ミグリオール（Dynamit Nobel
社製商品名）、ODO（日清製油株式会社製商品
名）、ホモテツクスRK（花王アトラス株式会社製
商品名）等の中鎖脂肪酸トリグリセライド類のよ
うな常温で液体状のものが挙げられる。この中性
油の使用量は補酵素Q10に対して５倍以上好まし
くは10〜20倍がよい。
また界面活性剤としてはソルビタンモノラウレ
ート、ソルビタンモノオレエート、ソルビタンセ
スキオレエート、ポリオキシエチレンソルビタン
モノオレエート、ポリオキシエチレンモノステア
レート、ポリオキシエチレンラウリルエーテル、
ポリオキシエチレン硬化ヒマシ油等の非イオン系
界面活性剤であり、このうち特にポリオキシエチ
レンソルビタンモノオレエート、ソルビタンモノ
ラウレート、ソルビタンモノオレエート、ソルビ
タンセスキオレエート等の常温で油状のものが好
ましい。界面活性剤の使用量は補酵素Q10に対し
て0.01〜２倍量、好ましくは0.05〜１倍量がよ
い。
補酵素Q10、中性油および界面活性剤の混合方
法としては三者が均一に溶解できる方法であれば
特に限定されるものではないが、特に補酵素Q10
を中性油に溶解せしめる際に70℃以上の加温を行
うと溶液の安定性は一層向上することが見出され
ている。
このようにして得られた補酵素Q10組成物は次
にソフトカプセルに充填されるが、その方法とし
ては例えば打ち抜き法、滴下法、浸漬法等が挙げ
られる。
本発明の補酵素Q10組成物は安定な溶液であ
り、長期間の保存あるいは保存環境の変化時にも
結晶が析出することがなく、また溶媒としての中
性油の量を減少することが可能であり、その結果
剤型を小さくできるという長所も有している。更
に、組成物自体が流動性に富むためにソフトカプ
セルへの充填の操作が非常に容易である。
次に本発明の効果を示す。なお下記の試験は試
験期間を短縮するため通常の保存状態より苛酷な
条件で行つた。
溶液の調整法
本発明(1)：補酵素Q100.2ｇ、中鎖脂肪酸トリグリ
セライド（ミグリオール812，Dynamit
Nobel社製）4.0ｇおよび界面活性剤（ソ
ルビタンモノオレエート）0.1ｇを室温で
撹拌混合して補酵素Q10の溶液を得る。
本発明(2)：本発明(1)と同様の配合割合で三者を撹
拌混合するがただし撹拌時に100℃におい
て５分間加熱する。
対照１：補酵素Q100.2ｇおよび中鎖脂肪酸トリグ
リセライド（ミグリオール812，Dynamit
Nobel社製）4.1ｇを室温で撹拌混合して
補酵素Q10の溶液を得る。
評価の方法
各々の方法で得られた補酵素Q10の溶液を−５
℃の冷蔵庫に保存し、３日ごとに12日目まで結晶
の析出状態を観察した。その試験結果を示せば下
表のとおりである。
The present invention relates to a coenzyme Q 10 -containing composition for filling soft capsules and a method for producing the same. Coenzyme Q10 is a substance that participates in the electron transport system in vivo and exhibits excellent pharmacological effects against various diseases. When providing this coenzyme Q 10 as a pharmaceutical, various dosage forms can be considered, but since the melting point of coenzyme Q 10 is as low as approximately 50°C, when it is made into a tablet, for example, coenzyme Q 10 is It melts and oozes onto the surface of the tablet, reducing its commercial value. Furthermore, even when hard capsules are used, there is a drawback that the drug adsorbed to the excipient melts and separates during storage. Therefore, the present inventors attempted to encapsulate coenzyme Q 10 into soft capsules, but in a short period of time, coenzyme Q 10
Coenzyme Q 10 crystals may precipitate and the fluidity of the solution is lost, making soft capsules impossible, or even if soft capsules can be produced, coenzyme Q 10 crystals may precipitate during storage, impairing absorption in the body. There was a drawback. Therefore, the present inventors conducted repeated research in order to obtain a solution of coenzyme Q 10 that is stable for a long period of time . It was discovered that a stable solution could be obtained, and the present invention was completed. The neutral oils referred to in the present invention include vegetable oils such as soybean oil, corn oil, peanut oil, and cottonseed oil, animal oils such as fish liver oil, and miglyol (Dynamit Nobel
Examples include medium-chain fatty acid triglycerides such as ODO (trade name, manufactured by Nisshin Oil Co., Ltd.), Homotex RK (trade name, manufactured by Kao Atlas Co., Ltd.), which are liquid at room temperature. The amount of neutral oil used is 5 times or more, preferably 10 to 20 times the amount of coenzyme Q10 . In addition, surfactants include sorbitan monolaurate, sorbitan monooleate, sorbitan sesquioleate, polyoxyethylene sorbitan monooleate, polyoxyethylene monostearate, polyoxyethylene lauryl ether,
Nonionic surfactants such as polyoxyethylene hydrogenated castor oil, among which those that are oily at room temperature such as polyoxyethylene sorbitan monooleate, sorbitan monolaurate, sorbitan monooleate, and sorbitan sesquioleate preferable. The amount of surfactant to be used is 0.01 to 2 times, preferably 0.05 to 1 times the amount of coenzyme Q10 . The method of mixing coenzyme Q 10 , neutral oil, and surfactant is not particularly limited as long as the three can be dissolved uniformly, but in particular coenzyme Q 10
It has been found that heating the solution to 70°C or higher when dissolving it in neutral oil further improves the stability of the solution. The coenzyme Q 10 composition thus obtained is then filled into soft capsules, for example by a punching method, a dropping method, a dipping method, and the like. The coenzyme Q 10 composition of the present invention is a stable solution, and crystals do not precipitate even during long-term storage or changes in the storage environment, and the amount of neutral oil as a solvent can be reduced. As a result, it also has the advantage that the dosage form can be made smaller. Furthermore, since the composition itself has high fluidity, filling it into soft capsules is very easy. Next, the effects of the present invention will be described. The following tests were conducted under more severe conditions than normal storage conditions in order to shorten the test period. Solution preparation method Invention (1): Coenzyme Q 10 0.2g, medium chain fatty acid triglyceride (miglyol 812, Dynamit
4.0 g (manufactured by Nobel) and 0.1 g of a surfactant (sorbitan monooleate) were mixed with stirring at room temperature to obtain a solution of coenzyme Q 10 . Present invention (2): The three components are stirred and mixed in the same proportion as in the present invention (1), except that during stirring, the mixture is heated at 100° C. for 5 minutes. Control 1: Coenzyme Q 10 0.2g and medium chain fatty acid triglycerides (Miglyol 812, Dynamit
4.1 g of Nobel Co., Ltd.) were stirred and mixed at room temperature to obtain a solution of coenzyme Q 10 . Evaluation method Coenzyme Q 10 solution obtained by each method was
It was stored in a refrigerator at ℃, and the state of crystal precipitation was observed every 3 days until the 12th day. The test results are shown in the table below.
【表】【table】
【表】
参考までに、上記の溶液の調整法および評価の
方法と同様にして補酵素Q10と中性油または補酵
素Q10と界面活性剤からなる組成物（対照２〜
５）を調製し、安定性を試験した。結果は次のと
おりであつた。
組 成
対照２：補酵素Q10 0.2ｇ
ゴマ油 4.1ｇ
対照３：補酵素Q10 0.2ｇ
ニツコールHCO―60※ 4.1ｇ
対照４：補酵素Q10 0.2ｇ
ポリオキシエチレンソルビタンモノオ
レエート 4.1ｇ
対照５：補酵素Q10 0.2ｇ
ソルビタンモノラウレート 4.1ｇ
※ 硬化ヒマシ油のポリオキシエチレン化誘
導体
（日光ケミカル社製）
結 果[Table] For reference, compositions consisting of coenzyme Q 10 and neutral oil or coenzyme Q 10 and surfactant (control 2 to
5) was prepared and tested for stability. The results were as follows. Composition Control 2: Coenzyme Q 10 0.2g Sesame oil 4.1g Control 3: Coenzyme Q 10 0.2g Nitsukor HCO-60* 4.1g Control 4: Coenzyme Q 10 0.2g Polyoxyethylene sorbitan monooleate 4.1g Control 5 : Coenzyme Q 10 0.2g Sorbitan monolaurate 4.1g * Polyoxyethylated derivative of hydrogenated castor oil (manufactured by Nikko Chemical Co., Ltd.) Results
【表】
以下に実施例により本発明を詳細に説明する。
実施例 １
補酵素Q100.2Kg、中鎖脂肪酸トリグリセライド
（ミグリオール812，Dynamit Nobel社製）2.00
Kg、およびソルビタンセスキオレエート（SO―
15、日光ケミカルズ(株)製）0.02Kgを室温で30分間
撹拌混合し、均一なソフトカプセル充填用補酵素
Q10組成物を得る。
この補酵素Q10の溶液をカプセル型Oval ３を
取りつけた打ち抜き法ソフトカプセル連続自動製
造機（Leiner ＆ Sons社製）に供給し、内容
物重量102mgのソフトカプセルを得た。なおソフ
トカプセルの製造に用いた剤皮配合組成物はゼラ
チン4.7Kg、グリセリン1.8Kgおよび水3.4Kgであ
り、剤皮の厚さは0.9mmとした。
実施例 ２
補酵素Q100.2Kg、とうもろこし油3.0Kgおよび
ソルビタンモノオレエート（TO―10、日光ケミ
カルズ(株)製）0.05Kgを撹拌混合しつつ100℃まで
加熱して補酵素Q10を溶解する。この溶液を約30
℃まで冷却しそしてソフトカプセル充填用補酵素
Q10組成物を得る。
次に実施例１と同様の剤皮配合組成のゼラチン
溶液を使用する二重円筒式カプセル製造機
（Globex International社製）によつて内容物重
量各162mgのシームレスカプセルを製造した。
実施例 ３
補酵素Q10 0.02Kgおよび大豆白絞油0.398Kgを
130℃に加熱しつつ撹拌する。補酵素Q10が溶解
したところで撹拌を止め、溶液を30℃に冷却した
後、ソルビタンモノラウレート（SL―10、日光
ケミカルズ(株)製）0.02Kgを加えて更に撹拌してソ
フトカプセル充填用補酵素Q10組成物を得る。
この補酵素Q10の溶液を加圧打抜法ソフトカプ
セル製造機（Leiner ＆ Sons社製）を用いて
内容物重量各300mgのソフトカプセルを得た。な
おソフトカプセルの製造に用いた剤皮配合はゼラ
チン２Kg、グリセリン0.4Kg、ソルビトール0.2Kg
および水2.5Kgであり、剤皮の厚さは1.0mmとし
た。
実施例 ４
補酵素Q10 10ｇ、中鎖脂肪酸トリグリセライ
ド（ミグリオール812、Dynamit Nobel社製）55
ｇおよびソルビタンセスキオレエート（SO―15、
日光ケミカルズ(株)製）0.2ｇを撹拌混合しつつ100
℃に加熱して補酵素Q10を溶解する。この溶液を
30℃に冷却してソフトカプセル充填用補酵素Q10
組成物を得る。
この補酵素Q10の溶液を打ち抜き法ソフトカプ
セル連続自動製造機（Leiner ＆ Sons社製）
で内容物重量各95.5mgのソフトカプセルを得た。
なおソフトカプセル製造に用いた剤皮は実施例３
と同様にした。
実施例 ５
補酵素Q10 10ｇ、中鎖脂肪酸エステル（ミグ
リオール812、Dynamit Nobel社製）150ｇおよ
びポリオキシエチレンソルビタンモノオレエート
１ｇを100℃で５分間撹拌混合して補酵素Q10を
完全に溶解させる。この液を室温まで冷却した後
平板打ち抜き法により１カプセル当り内容物161
mg含有するソフトカプセルを得た。[Table] The present invention will be explained in detail with reference to Examples below. Example 1 Coenzyme Q 10 0.2Kg, medium chain fatty acid triglyceride (Miglyol 812, manufactured by Dynamit Nobel) 2.00
Kg, and sorbitan sesquioleate (SO—
15, Nikko Chemicals Co., Ltd.) 0.02Kg was stirred and mixed at room temperature for 30 minutes to form a uniform coenzyme for filling soft capsules.
Obtain Q10 composition. This coenzyme Q 10 solution was supplied to a continuous automated punching method soft capsule manufacturing machine (manufactured by Leiner & Sons) equipped with a capsule type Oval 3 to obtain soft capsules with a content weight of 102 mg. The shell combination composition used to produce the soft capsules contained 4.7 kg of gelatin, 1.8 kg of glycerin, and 3.4 kg of water, and the thickness of the shell was 0.9 mm. Example 2 0.2 kg of coenzyme Q 10 , 3.0 kg of corn oil, and 0.05 kg of sorbitan monooleate (TO-10, manufactured by Nikko Chemicals Co., Ltd.) were mixed with stirring and heated to 100°C to dissolve coenzyme Q 10 . do. Approximately 30% of this solution
Cool to ℃ and coenzyme for soft capsule filling
Obtain Q10 composition. Next, seamless capsules each having a content weight of 162 mg were manufactured using a double cylindrical capsule manufacturing machine (manufactured by Globex International) using a gelatin solution having the same shell composition as in Example 1. Example 3 Coenzyme Q 10 0.02Kg and soybean white squeezed oil 0.398Kg
Stir while heating to 130°C. When Coenzyme Q 10 was dissolved, stirring was stopped and the solution was cooled to 30°C. After that, 0.02 kg of sorbitan monolaurate (SL-10, manufactured by Nikko Chemicals Co., Ltd.) was added and further stirred to prepare a supplement for soft capsule filling. Obtain Enzyme Q 10 composition. This coenzyme Q 10 solution was used to obtain soft capsules each having a content weight of 300 mg using a pressure punching method soft capsule manufacturing machine (manufactured by Leiner & Sons). The shell combination used to manufacture the soft capsules was 2 kg of gelatin, 0.4 kg of glycerin, and 0.2 kg of sorbitol.
and 2.5 kg of water, and the thickness of the coating was 1.0 mm. Example 4 Coenzyme Q 10 10g, medium chain fatty acid triglyceride (Miglyol 812, manufactured by Dynamit Nobel) 55
g and sorbitan sesquioleate (SO-15,
100 while stirring and mixing 0.2 g of Nikko Chemicals Co., Ltd.
Dissolve coenzyme Q10 by heating to 10°C. This solution
Coenzyme Q 10 for soft capsule filling after cooling to 30℃
Obtain a composition. This coenzyme Q 10 solution is punched out using a continuous automatic manufacturing machine for soft capsules (manufactured by Leiner & Sons).
Soft capsules each having a content weight of 95.5 mg were obtained.
The shell used for producing soft capsules was Example 3.
I did the same thing. Example 5 10 g of coenzyme Q 10 , 150 g of medium chain fatty acid ester (Miglyol 812, manufactured by Dynamit Nobel) and 1 g of polyoxyethylene sorbitan monooleate were stirred and mixed at 100°C for 5 minutes to completely dissolve coenzyme Q 10 . let After cooling this liquid to room temperature, the contents per capsule were 161
Soft capsules containing mg were obtained.
Claims (1)
することを特徴とする、ソフトカプセル充填用補
酵素Q10含有組成物。 ２ 補酵素Q10、中性油および界面活性剤を70℃
以上に加熱することを特徴とする、ソフトカプセ
ル充填用補酵素Q10含有組成物の製法。[Scope of Claims] 1. A coenzyme Q 10- containing composition for filling soft capsules, characterized by containing coenzyme Q 10 , a neutral oil, and a surfactant. 2 Coenzyme Q 10 , neutral oil and surfactant at 70℃
A method for producing a coenzyme Q 10 -containing composition for filling soft capsules, the method comprising heating to a temperature above.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15460978A JPS5581813A (en) | 1978-12-16 | 1978-12-16 | Composition containing coenzyme q10 and its perparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15460978A JPS5581813A (en) | 1978-12-16 | 1978-12-16 | Composition containing coenzyme q10 and its perparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5581813A JPS5581813A (en) | 1980-06-20 |
| JPS6339566B2 true JPS6339566B2 (en) | 1988-08-05 |
Family
ID=15587913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15460978A Granted JPS5581813A (en) | 1978-12-16 | 1978-12-16 | Composition containing coenzyme q10 and its perparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5581813A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0236472U (en) * | 1988-08-31 | 1990-03-09 | ||
| US10950329B2 (en) | 2015-03-13 | 2021-03-16 | Mmodal Ip Llc | Hybrid human and computer-assisted coding workflow |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5877810A (en) * | 1981-11-01 | 1983-05-11 | Taiho Yakuhin Kogyo Kk | Oral drug composition containing polyglycerol unsaturated fatty acid ester |
| JPS61221131A (en) * | 1985-03-28 | 1986-10-01 | Eisai Co Ltd | Ubidecarenone-containing composition having promoted absorption |
| JPH0665645B2 (en) * | 1985-09-18 | 1994-08-24 | 日清製粉株式会社 | Self-emulsifying soft capsule drug solution |
| US5258179A (en) * | 1989-10-27 | 1993-11-02 | Nestec S.A. | Protection of a food, cosmetic or pharmaceutical product against oxidation |
| IT1263840B (en) * | 1993-03-30 | 1996-09-04 | Giuseppe Furiosi | ORAL FORMULATIONS OF UBIDECARENONE IN THE FORM OF CAPSULES |
| US6616942B1 (en) * | 1999-03-29 | 2003-09-09 | Soft Gel Technologies, Inc. | Coenzyme Q10 formulation and process methodology for soft gel capsules manufacturing |
| US6623734B2 (en) * | 2000-06-22 | 2003-09-23 | Soft Gel Technologies, Inc. | Super absorption coenzyme Q10 |
| DE10133305B4 (en) * | 2001-07-12 | 2004-06-03 | Aquanova German Solubilisate Technologies (Agt) Gmbh | Ubiquinone concentrate |
| WO2003007928A1 (en) * | 2001-07-17 | 2003-01-30 | Idemitsu Kosan Co., Ltd. | Ascites preventives for poultry |
| TW200302056A (en) * | 2002-01-18 | 2003-08-01 | Kaneka Corp | Method for stabilizing reduced coenzyme Q10 and composition therefor |
| KR100724326B1 (en) * | 2003-01-17 | 2007-06-04 | 타이요 카가꾸 가부시키가이샤 | Coenzyme Ｑ10-containing composition |
| JP2005047851A (en) * | 2003-07-29 | 2005-02-24 | Nisshin Pharma Inc | Ubidecarenone-containing composition |
| US7169385B2 (en) | 2003-09-29 | 2007-01-30 | Ronald G. Udell | Solubilized CoQ-10 and carnitine |
| US8105583B2 (en) | 2003-09-29 | 2012-01-31 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 |
| US8124072B2 (en) | 2003-09-29 | 2012-02-28 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 |
| MY153288A (en) * | 2006-06-28 | 2015-01-29 | Hovid Berhad | An effective pharmaceutical carrier for poorly bioavailable drugs |
| JP2008005813A (en) * | 2006-06-30 | 2008-01-17 | Ezaki Glico Co Ltd | Coenzyme q10-containing chocolate |
-
1978
- 1978-12-16 JP JP15460978A patent/JPS5581813A/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0236472U (en) * | 1988-08-31 | 1990-03-09 | ||
| US10950329B2 (en) | 2015-03-13 | 2021-03-16 | Mmodal Ip Llc | Hybrid human and computer-assisted coding workflow |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5581813A (en) | 1980-06-20 |
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