JPS6343368B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION BACKGROUND OF THE INVENTION Technical Field The present invention relates to sugar-loaded amino acid infusions. More specifically, the present invention provides a sugar-containing amino acid infusion containing maltitol and/or lactitol as the sugar. Prior Art and its Problems Glucose, a reducing sugar, is preferable as a heat source, but when mixed with amino acids, it has the disadvantage of browning of the infusion solution due to the Maillard reaction under autoclaving conditions.
Sugar-containing amino acid infusions have been prepared by mixing sugar alcohols such as sorbitol, xylitol, and amino acids, but these sugar alcohols are monosaccharide alcohols and have a lower weight than maltitol and lactitol, which are disaccharide alcohols. Since it increases the osmotic pressure by about twice the amount added, it is not necessarily preferable as a heat source. Purpose of the Invention As a result of extensive research, the present inventors have discovered that maltitol and/or lactitol, which are disaccharide alcohols whose osmotic pressure is approximately 1/2 of that of monosaccharide alcohols at the same weight, are mixed with amino acids. The present inventors have discovered that a new sugar-containing amino acid infusion is a stable new sugar-combined amino acid infusion that does not cause Maillard reaction, and has completed the present invention. DETAILED DESCRIPTION OF THE INVENTION That is, the present invention is an amino acid infusion containing a sugar, which is characterized in that the infusion contains maltitol and/or lactitol as sugar in an aqueous solution. In addition, the aqueous solution contains a range of concentrations of sugars, amino acids, and electrolyte elements such as maltitol and/or lactitol.
50-250g/L-isoleucine 2.0-10.7g/L-leucine 3.8-17.2g/L-valine 2.3-11.3g/L-phenylalanine 2.0-9.9g/L-tyrosine 0.1-0.9g/L-tryptophan 0.3 ~2.6g/L-cysteine 0-1.4g/L-methionine 1.0-5.0g/L-arginine 2.9-14.1g/L-histidine 1.1-6.3g/L-lysine 1.8-13.2g/L-aspartic acid 0- 1.3g / L-glutamic acid 0-1.3g / L-alanine 2.0-11.3g / Glycine 1.5-10.5g / L-proline 1.4-10.7g / L-serine 0.8-5.9g / L-threonine 1.2-7.2g / Sodium 0-100 mmol / Potassium 10-60 mmol / Chlorine 0-100 mmol / Phosphorus 3-20 mmol / Calcium 1-6 mmol / Magnesium 1-6 mmol / Zinc 0-40 μmol / Chromium 0-0 μmol / It is preferable that it is. Maltitol and lactitol used in the present invention can be obtained by catalytic reduction or NaBH ₄ reduction of maltose and lactose, respectively. The sugar-containing amino acid infusion of the present invention contains distilled water for injection and the electrolyte elements shown in Table 1. Electrolytes containing sodium in Table 1 include table salt, sodium lactate, and sodium citrate; for potassium, potassium chloride,
Potassium monohydrogen phosphate, potassium dihydrogen phosphate, potassium gluconate, potassium acetate,

【table】

[Table] For potassium citrate and magnesium, list magnesium chloride and magnesium sulfate. For calcium, list calcium lactate, calcium chloride, and calcium gluconate. For zinc, list zinc chloride and zinc sulfate. For chromium, list chromium acetate and chromium chloride. and can be appropriately selected and used from these. The sugar-containing amino acid infusion of the present invention is filled into a vial or a plastic container inert to the infusion, the filling opening is then sealed, and the container is sterilized by high-pressure steam sterilization. The container is preferably made of plastic, which is inert to infusions because it does not generate flakes. In addition, in order to prevent contamination of the infusion solution due to contact with the outside air during use, and to prevent deterioration such as oxidation of the infusion solution due to oxygen in the outside air, a plastic container that is inert to the infusion solution does not require introducing outside air into the container. Buzz is desirable. The bag may be made of soft vinyl chloride resin, ethylene/vinyl acetate copolymer, acid resin, or the like. The soft vinyl chloride resin is preferably one obtained by graft polymerizing or block polymerizing a plastic monomer onto vinyl chloride, or one obtained by blending a plastic polymer with polyvinyl chloride. Specific Effects of the Invention It was confirmed that the sugar-containing amino acid infusion of the present invention does not cause the Maillard reaction under high-pressure steam sterilization conditions at 121°C for 20 minutes. Furthermore, since the sugar-containing amino acid infusion does not involve direct intravenous administration of glucose, it is also preferable as a therapeutic infusion for patients with impaired glucose tolerance. Next, the present invention will be explained in detail with reference to Examples. Example 1 L-isoleucine in distilled water for injection at about 70°C
28g, L-leucine 48g, L-valine 30g, L-
Tryptophan 6g, L-phenylalanine 26g
g, L-tyrosine 2g, L-lysine hydrochloride 37g,
L-methionine 13g, L-threonine 18g, L-
Alanine 28g, L-arginine 38g, L-histidine 16g, L-proline 24g, L-serine 14g,
Add 25 g of glycine, 2 g of L-aspartic acid, 2 g of L-glutamic acid, and 3 g of L-cysteine hydrochloride and stir to dissolve. Furthermore, 85.4 g of 50W/W% sodium lactate, 20.4 g of potassium monohydrogen phosphate, 19.6 g of potassium acetate, 3 g of magnesium chloride hexahydrate, and 500 g of maltitol were added and stirred to dissolve. Next, add 3.7 g of calcium chloride dihydrate and stir to dissolve.
Finally, adjust the pH to 5.5 and make a solution of 10 with distilled water for injection. The solution was filtered, dispensed into plastic bags in 500 ml portions, filled with nitrogen, and sterilized with high-pressure steam at 120°C for 20 minutes to produce a sugar-containing amino acid infusion with an osmotic pressure ratio of 2.3. When the transmittance of the sugar-containing amino acid infusion was measured using a spectrophotometer at 420 nm, the transmittance was 99.8%, indicating that no Maillard reaction occurred. Example 2 L-isoleucine in distilled water for injection at about 70°C
32g, L-leucine 54g, L-valine 34g, L-
Tryptophan 7g, L-phenylalanine 30g
g, L-tyrosine 2g, L-lysine 35g, L-methionine 15g, L-threonine 20g, L-alanine 32g, L-arginine 43g, L-histidine 18
Add and stir to dissolve 27 g of L-proline, 16 g of L-serine, 28 g of glycine, 2 g of L-aspartic acid, 2 g of L-glutamic acid, and 2 g of L-cysteine. In addition, 50W/W% sodium lactate 85.4g, potassium dihydrogen phosphate 20.4g, potassium acetate 19.6g,
Magnesium chloride hexahydrate 3g, lactitol
Add 500g and stir to dissolve. Then, add 3.7 g of calcium chloride dihydrate to adjust the pH to 5.5 and make a solution with distilled water for injection. After evaporation, the solution was dispensed into 500 ml plastic bags, sealed, and autoclaved at 110°C for 60 minutes to obtain an amino acid infusion containing lactitol with an osmotic pressure ratio of 2.4. When the transmittance of the infusion at 420 nm was measured using a spectrophotometer, the transmittance was 99.6%, and it was clear and colorless. Example 3 Maltitol and lactitol were used alone or in a blend at a concentration within the range shown in Table 1, and amino acids and electrolytes were also set at concentrations within the range shown in Table 1. The sugar-containing amino acid infusion prepared as shown in Example 1 was clear and colorless, and no Maillard reaction occurred. Further, as a comparative example, when maltose, a disaccharide, was used in place of maltitol and lactitol in Examples 1 to 3, Maillard reaction occurred in all cases.

Claims (1)

[Scope of Claims] 1. An amino acid infusion containing sugar, characterized in that the infusion contains maltitol and/or lactitol as sugar in an aqueous solution. 2 The aqueous solution has a concentration range of sugars, amino acids and electrolyte elements such as maltitol and/or lactitol.
50-250g/L-isoleucine 2.0-10.7g/L-leucine 3.8-17.2g/L-valine 2.3-11.3g/L-phenylalanine 2.0-9.9g/L-tyrosine 0.1-0.9g/L-tryptophan 0.3 ~2.6g/L-cysteine 0-1.4g/L-methionine 1.0-5.0g/L-arginine 2.9-14.1g/L-histidine 1.1-6.3g/L-lysine 1.8-13.2g/L-aspartic acid 0- 1.3g / L-glutamic acid 0-1.3g / L-alanine 2.0-11.3g / Glycine 1.5-10.5g / L-proline 1.4-10.7g / L-serine 0.8-5.9g / L-threonine 1.2-7.2g / Sodium 0-100 mmol / Potassium 10-60 mmol / Chlorine 0-100 mmol / Phosphorus 3-20 mmol / Calcium 1-6 mmol / Magnesium 1-6 mmol / Zinc 0-40 μmol / Chromium 0-1 μmol / The sugar-containing amino acid infusion according to claim 1.