JPS6343369B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION BACKGROUND OF THE INVENTION Technical Field The present invention relates to carbohydrate infusions. More specifically, the object is to provide a carbohydrate infusion containing palatinose. Prior Art and its Problems Various carbohydrate infusions are commercially available, and are prepared using glucose, fructose, sorbitol, xylitol, and maltose as carbohydrates. With the exception of maltose, these carbohydrates are monosaccharides. In infusions where osmotic pressure must be considered, monosaccharides increase osmotic pressure by about twice as much as disaccharides when added in the same weight amount. Furthermore, since maltose is a reducing sugar, it has an acetal structure in which the aldehyde group is masked in terms of its chemical structure, and it is not necessarily preferable because it has instability peculiar to compounds having an aldehyde group. Purpose of the Invention As a result of extensive research, the present inventors succeeded in preparing an intravenous infusion containing palatinose, and discovered that the infusion had excellent properties as a nutritional infusion. I've reached it. DETAILED DESCRIPTION OF THE INVENTION That is, the present invention is a carbohydrate infusion characterized by containing palatinose in an aqueous solution. In the aqueous solution, the concentration range of sugar and elements in the electrolysis is Palatinose 50-350 g / Sodium 0-100 mmol / Potassium 10-60 mmol / Chlorine 0-100 mmol / Phosphorus 3-10 mmol / Magnesium 1-6 mmol / Calcium 1 It is desirable that the amount is ~6 mmol/zinc 0-40 micromol/chromium 0-1 micromol/. The palatinose used in the present invention is obtained by converting sugar with enzymes in certain bacteria. The carbohydrate infusion of the present invention can be obtained by adding palatinose and, if necessary, the electrolytes shown in Table 1 to distilled water for injection and stirring.

[Table] Electrolytes containing sodium in Table 1 include NaCl, sodium lactate, and sodium citrate, and potassium includes KCl, K ₂ HPO ₄ ,
KH ₂ PO ₄ , potassium gluconate, potassium acetate,
For potassium citrate, magnesium
MgCl ₂ , MgSO ₄ , calcium lactate, CaCl ₂ , calcium gluconate for calcium,
ZnSO ₄ and ZnCl ₂ can be used for zinc, and Cr(OAc) ₃ and CrCl ₃ can be used for chromium, and an appropriate one can be selected from these. The carbohydrate infusion of the present invention is filled into a vial or a plastic container inert to the infusion, the filling opening is then sealed, and the container is sterilized by high-pressure steam sterilization. As the container, it is preferable to use a plastic container that is inert to the infusion because it does not generate flakes. In addition, in order to prevent contamination of the infusion solution due to contact with the outside air during use, and to prevent deterioration of the infusion solution due to oxidation due to oxygen in the outside air, we use plastic containers that are inert to the infusion solution and do not require outside air to be introduced into the container. Buzz is desirable. The bag may be made of soft vinyl chloride resin, ethylene vinyl acetate copolymer, acid resin, or the like. The soft vinyl chloride resin is preferably one obtained by graft polymerizing or block polymerizing a plastic monomer onto vinyl chloride, or one obtained by blending a plastic polymer with polyvinyl chloride. Specific Effects of the Invention It was confirmed that the carbohydrate infusion of the present invention has an excellent nutritional supplementation effect when administered intravenously. Also,
Since this carbohydrate infusion does not directly administer glucose intravenously, a rapid rise in blood sugar is suppressed, and it can be used as a therapeutic infusion for diabetic patients with decreased glucose tolerance or post-operative diabetic patients. . The present invention will be specifically explained with reference to the following Examples and Test Examples, but the present invention is not limited thereto. Example The ingredients shown in Table 2 were dissolved in sterilized distilled water in the proportions listed under stirring. The resulting aqueous solution was adjusted to pH 4.7 with lactic acid. After the resulting aqueous solution has been sterilized, it is dispensed into plastic bags in 500 ml portions and sealed, followed by high-pressure steam sterilization at 115° for 30 minutes to obtain a carbohydrate infusion.

[Table] Test Example A catheter was placed in the jugular vein of a male Wistar rat weighing approximately 270 g. 1 group 5
The animals were divided into three groups and the first group received commercially available glucose.
20% of Haikaritsuku No. 2 (trade name of high-calorie infusion manufactured by Terumo Corporation), which is a carbohydrate infusion containing 25W/V%.
ml was continuously injected for 5 hours every day for 5 days, and 6 g (24.6 Kcal/day) of enteral nutrition was administered enterally for 5 consecutive days. In the second group, 20 ml of the carbohydrate infusion prepared in Example 1 was infused for 5 hours every day, and 6 g of the above enteral nutrition was administered enterally for 5 days. The third group received 6 g of the above enteral nutritional supplement under the same conditions as the first and second groups without infusion. Each group was allowed free access to water. Weight changes in each group were examined on the 6th day. The results are shown in Table 3. There was no significant difference between Group 1 and Group 2, and it was clear that weight loss was significantly suppressed compared to Group 3. .

[Table] Furthermore, in this example, no disorders or toxic signs that were considered to be caused by the carbohydrate infusion of the present invention were observed.

Claims (1)

[Scope of Claims] 1. A carbohydrate infusion, characterized in that the infusion contains palatinose in an aqueous solution. 2 The aqueous solution has a concentration range of sugar and electrolyte elements: Palatinose 50-350 g / Sodium 0-100 mmol / Potassium 10-60 mmol / Chlorine 0-100 mmol / Phosphorus 3-10 mmol / Magnesium 1-6 mmol / Calcium 1 The carbohydrate infusion according to claim 1, which has a content of ~6 mmol/zinc 0-40 micromol/chromium 0-1 micromol/.