JPS6346724B2 - - Google Patents

Description

[Detailed description of the invention] The present invention relates to a medicinal poultice base material.

Conventionally, various hydrophilic polymer substances have been used as thickeners in medicinal poultice base materials. Such hydrophilic polymeric substances are required to have a large thickening effect, shape-forming properties, and excellent water retention properties. If a thickening agent with a large thickening effect and excellent excipient properties is used, the poultice will not "sag" even in the hot and humid summer months or due to sweating. Research has already been carried out on the relationship between the water retention properties of poultices and their medicinal efficacy. For example, according to Japanese Patent Application Laid-Open No. 18618/1983, the more water there is in a poultice, the more the drug will penetrate into the skin, making it more effective at removing inflammation. be effective. Furthermore, even in the case of hot compresses, it is said that the higher the water retention capacity at high temperatures, and the more stable water the compresses contain, the greater the compressive effect. Conventionally, such hydrophilic polymer substances include, for example, natural or semi-synthetic natural products such as sodium alginate, gelatin,
Agar, carboxymethyl cellulose, starch derivatives, etc. are used, and as synthetic products, polyethylene glycol, polyvinyl alcohol, etc. are used. However, when these thickeners are incorporated into poultices, they have the drawbacks of insufficient thickening properties and poor water retention.

Other examples of such hydrophilic polymer substances include:
Examples include sodium polyacrylate. Sodium polyacrylate is produced stably industrially.
It is a high-molecular substance that has excellent water retention and is highly safe for the human body and is approved as a food additive. However, sodium polyacrylate is manufactured under alkaline conditions in order to obtain it industrially stably, and as a result, industrially obtained sodium polyacrylate exhibits a high PH value when it comes into contact with water or dissolves, making it difficult to use as a medicinal poultice. It is not preferable to use it as a base thickener or water retention agent because the poultice comes into direct contact with the skin and because of the stability of the drugs coexisting in the poultice. In order to eliminate some of the negative effects caused by this high PH value, attempts have been made to lower the PH value by using sodium polyacrylate in combination with organic acids or inorganic acids, but this has resulted in significant problems in thickening and water retention. The results have not been favorable. Further, although sodium polyacrylate has excellent water retention, it has an insufficient thickening effect on the medicinal poultice base, and has the drawback of being somewhat inferior in formability.

The present inventors have discovered that, as a thickener for medicinal poultice base materials,
As a result of intensive research to solve the above-mentioned problems when using sodium polyacrylate, which has excellent water retention properties, we have developed a compress using polyacrylate or polymethacrylate with a specific composition that has a cross-linked structure. As a thickener for medicinal base materials, we have discovered that it has excellent thickening properties, shaping properties, and water retention properties, and can be adjusted to a pH range that is safe for the skin, and we have completed the present invention. It has been reached.

That is, the present invention provides (a) 0 to 50 mol% of acrylic acid and/or methacrylic acid, (b) monovalent metal salts, divalent metal salts, and ammonium salts of acrylic acid or methacrylic acid. (c) ethylene glycol di(meth)acrylate, diethylene glycol di(meth)acrylate, triethylene glycol di(meth)acrylate, trimethylolpropane tri(meth)acrylate; ) acrylate, pentaerythritol tri(meth)acrylate, N,N'-
0.001 to 5 mol% of at least one crosslinkable monomer selected from the group consisting of methylene bis(meth)acrylamide, triallyl isocyanurate, and pentaerythritol di(meth)acrylate;
(d) 0 monomers copolymerizable with each component of (a), (b) and (c)
The present invention relates to a medicinal poultice base material containing ~10 mol% of polymer (1).

The polymer (1) used in the present invention is as described above (a),
This is derived from components (b), (c), and (d).

Component (a), acrylic acid and/or methacrylic acid, is used in an amount of 50 mol% or less based on the total monomer components. Acrylic acid and/or methacrylic acid
If it exceeds 50 mol%, the pH of the obtained poultice medicinal base material when it comes into contact with water or sweat is low, which is not preferable from the viewpoint of safety for the skin.

As component (b), one or more monomers selected from the group consisting of monovalent metal salts, divalent metal salts, and ammonium salts of acrylic acid or methacrylic acid are used. As the monovalent or divalent metal salt, alkali metal salts and alkaline earth metal salts are preferred.
(b) The amount of component used is 45 to 45% of the total monomer components.
The amount is 99.999 mol%.

Among such components (A) and (B), in the present invention, acrylic acid is used as the (A) component, sodium acrylate is used as the (B) component, and the ratio of acrylic acid and sodium acrylate is 5. ~50: It is preferable that the ratio is in the range of 50 to 95.

Component (c) is a crosslinkable monomer having two or more polymerizable double bonds in its molecule. Examples of such crosslinkable monomers include ethylene glycol diacrylate, ethylene glycol dimethacrylate, diethylene glycol diacrylate, diethylene glycol dimethacrylate, triethylene glycol diacrylate, triethylene glycol dimethacrylate, and trimethylolpropane triacrylate. , trimethylolpropane trimethacrylate, pentaerythritol triacrylate, pentaerythritol trimethacrylate, N,N'-methylenebisacrylamide, triallyl isocyanurate, pentaerythritol diacrylate, pentaerythritol dimethacrylate, etc. One type or two or more types selected from these can be used. The amount of the crosslinking monomer used is in the range of 0.001 to 5 mol% based on the total monomer components. If the amount of the crosslinking monomer used is less than 0.001 mol%, the thickening properties for the resulting poultice medicinal base material will not be sufficient, and even if it is used in an amount exceeding 5 mol%, the effect commensurate with the amount used will not be obtained. I can't.

Component (d) is a monomer copolymerizable with components (a), (b), and (c). Such monomers include methyl acrylate, 2-hydroxyethyl acrylate, 2-hydroxyethyl methacrylate, acrylamide, maleic acid and its salts, fumaric acid and its salts, acrylonitrile, vinyl acetate, etc. One or more selected types can be used. The amount of monomer used as component (d) is 10 mol% or less based on the total monomer components. If it is used in an amount exceeding 10 mol%, the thickening properties of the medicinal poultice base material will decrease.

Various conventionally known methods can be used to derive the polymer (1) from each of the components (a), (b), (c) and (d). For example, a method in which components (a), (b), (c), and (d) are mixed and dissolved in water, a radical polymerization initiator is added, and polymerization is performed without stirring; (a), (b), A method in which components (c) and (d) are mixed and dissolved in water and then emulsified or suspended in a hydrophobic organic solvent for polymerization; component (a), acid constituting component (b), and component (c). Component (d) is dissolved in an organic solvent and subjected to precipitation polymerization in the presence of a radical polymerization initiator, and the resulting polymer is treated with a monovalent metal, 2
A method such as neutralizing with a valent metal or ammonium to obtain a polymer (1) derived from each component (a), (b), (c) and (d) can be used. Of course, the scope of the present invention is not limited by such a polymerization method. The polymer (1) thus obtained is dried and pulverized to form a powder for better workability for obtaining the poultice medicinal base material of the present invention.

The medicinal poultice base material of the present invention contains the polymer (1) as an essential component, and contains bentonite, titanium oxide, kaolin,
Powdered substances such as zinc oxide; glycerin, sorbitol, polyvinyl alcohol, sodium alginate,
Adhesive, water-retaining, moisturizing, and shape-preserving agents such as gelatin, agar, sodium polyacrylate, polyacrylic acid, crosslinked polyacrylic acid, carboxymethyl cellulose sodium salt, polyethylene glycol, polyethylene oxide, and polybutene; water; and as necessary and other additives. The method and order of mixing these components are not particularly limited.

The amount of polymer (1) used is 0.5 to 0.5 in the poultice medicinal base material.
A proportion of 20% by weight is preferred. If the amount is less than 0.5% by weight, the thickening effect and water retention will not be sufficient.
Moreover, if the amount exceeds 20% by weight, the viscosity becomes too high and the workability when spreading onto pieces of cloth etc. becomes poor.

When obtaining a medicinal poultice base material based on the present invention, if the polymer (1) and a polyhydric alcohol are used together, the resulting medicated poultice base material will have a better thickening effect and workability for spreading onto pieces of cloth, etc. become something. Examples of such polyhydric alcohols include ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, glycerin, sorbitol, and mixtures thereof.

The poultice base material of the present invention can be made into a poultice by spreading it as it is on a piece of cloth such as a non-woven fabric and pasting a protective film such as polyethylene on the surface thereof. In addition, the poultice medicinal base material of the present invention contains l.
- By adding stimulants such as menthol, camphor, methyl salicylate, thymol, and pepper oil, and antiallergic agents such as diphenhydramine hydrochloride and chlorpheniramine maleate, the poultice becomes even more effective. Can be done. Such irritants and antiallergic agents may be added to and mixed with a poultice medicinal base material prepared in advance, or may be added and mixed with other components at the time of preparing the poultice medicinal base material.

The medicinal poultice base material of the present invention thus obtained has good shaping properties and does not "sag" even during high temperature and high humidity in summer or due to sweating. In addition, it has excellent water retention properties, and even when stored as a poultice for a long time, there is no movement of moisture into fabrics or hardening due to water evaporation. When using it, it is safe to use as there is no PH effect on the skin, and it has an excellent compressive effect due to the large amount of water it contains, and even when used as a warm compress, it has good water retention even at high temperatures and does not harden for a long time. It is something that can be used for hours.

Hereinafter, the present invention will be explained in more detail with reference to Examples.

Example 1 81.0 g of acrylic acid (25 mol% based on the total monomers), 316.8 g of sodium acrylate (74.9 mol%),
Trimethylolpropane triacrylate 1.33g
(0.1 mol%), 2 g of polyoxyethylene sorbitan fatty acid ester, and 599 g of water were mixed, placed in a closed container with an internal volume of 1 that can be opened and closed, and heated to 40°C under a nitrogen atmosphere. g and sodium bisulfite 0.05
g was added to carry out a polymerization reaction. After the polymerization reaction was completed, the obtained gel-like hydrous polymer was dried and then ground to obtain a polymer powder.

10g of this polymer powder, 40g of glycerin, 20g of kaolin, 10g of gelatin, 4g of sodium alginate
and 104 g of warm water were kneaded to prepare a poultice medicinal base material. The viscosity of this base material (B type viscosity, 2rm) is 4.0×
10 ⁶ cps or more, and the pH (measured by diluting the base material 10 times by weight with water) was 7.1.

For comparison, a medicinal poultice base material was prepared with the same composition except that a commercially available high molecular weight sodium polyacrylate was used instead of the crosslinked sodium polyacrylate powder, and the viscosity of this base material was 1.26 × 10 ⁶ cds. Yes, PH
(measured by diluting the base material 10 times by weight with water) is high;
It was 9.1. It is clear from this that the medicinal poultice base material of the present invention has a very large thickening effect and therefore has very excellent formability, and also shows a pH value that is safe for human skin.

Example 2 81.0 g of acrylic acid (25 mol% of the total monomers), 316.8 g of sodium acrylate (74.9 mol% of the total monomers),
0.69 g of methylene bisacrylamide (0.1 mol%) and 599 g of water were mixed, placed in an openable and closable airtight container with an internal volume of 1, heated to 40°C under a nitrogen atmosphere, and 0.15 g of ammonium persulfate was used as a polymerization initiator.
g and 0.05 g of sodium hydrogen sulfite were added to carry out a polymerization reaction. After the polymerization reaction was completed, the obtained gel-like hydrous polymer was dried and then ground to obtain a polymer powder.

10g of this polymer powder, 40g of glycerin, 20g of kaolin, 10g of gelatin, 4g of sodium alginate
and 104 g of warm water were kneaded to prepare a poultice medicinal base material. Viscosity of this base material (B type viscometer, 2 rpm) 4.0×
10 ⁶ cps or more, and the pH (measured by diluting the base material 10 times by weight with water) was 7.1.

Example 3 81.0 g of acrylic acid (25 mol% of the total monomers), 316.8 g of sodium acrylate (74.9 mol% of the total monomers),
Ethylene glycol diacrylate 0.76g (same
0.1 mol%) and water, 599 g were mixed, and the internal volume was 1
Place it in an airtight container that can be opened and closed under a nitrogen atmosphere.
The mixture was heated to 40° C., and 0.15 g of ammonium persulfate and 0.05 g of sodium bisulfite were added as polymerization initiators to carry out a polymerization reaction. After the polymerization reaction was completed, the obtained gel-like hydrous polymer was dried and then ground to obtain a polymer powder.

10g of this polymer powder, 40g of glycerin, 20g of kaolin, 10g of gelatin, 4g of sodium alginate
and 104 g of warm water were kneaded to prepare a poultice medicinal base material. The viscosity of this base material (B-type viscometer, 2 rpm) is
It was 4.0×10 ⁶ cps or more, and the pH (measured by diluting the base material 10 times by weight with water) was 7.1.

Example 4 81.0 g of acrylic acid (25 mol% based on the total monomers), 316.8 g of sodium acrylate (74.9 mol%),
Pentaerythritol triacrylate 1.3g
(0.1 mol%) and 599 g of water were mixed, placed in an openable and closable airtight container with an internal volume of 1, heated to 40°C under a nitrogen atmosphere, and added with 0.15 g of ammonium persulfate and 0.05 g of sodium bisulfite as polymerization initiators. was added to carry out a polymerization reaction. After the polymerization reaction is completed,
The obtained gel-like hydrous polymer was dried and then ground to obtain a polymer powder.

10g of this polymer powder, 40g of glycerin, 20g of kaolin, 10g of gelatin, 4g of sodium alginate
and 104 g of warm water were kneaded to prepare a poultice medicinal base material. The viscosity of this base material (B type viscometer, 2 rpm) is 4.0
×10 ⁶ cps or more, and the pH (measured by diluting the base material 10 times by weight with water) was 7.1.

Example 5 81.0 g of acrylic acid (25 mol% based on the total monomers), 316.8 g of sodium acrylate (74.9 mol%), 1.1 g of triallyl isocyanurate (0.1 mol%) and 599 g of water were mixed. , heated to 40°C in an open and closed container with an internal volume of 1, and added 0.15 g of ammonium persulfate as a polymerization initiator.
and 0.05 g of sodium bisulfite were added to carry out a polymerization reaction. After the polymerization reaction was completed, the resulting gel-like hydrous polymer was dried and then ground to obtain a polymer powder.

10g of this polymer powder, 40g of glycerin, 20g of kaolin, 10g of gelatin, 4g of sodium alginate
and 104 g of warm water were kneaded to prepare a poultice medicinal base material. The viscosity of this base material (B type viscometer, 2 rpm) is 4.0
×10 ⁶ cps or more, and the pH (measured by diluting the base material 10 times by weight with water) was 7.1.

Claims (1)

[Claims] 1 (a) 0 acrylic acid and/or methacrylic acid
~50 mol% (b) One or more monomers selected from the group consisting of monovalent metal salts, divalent metal salts, and ammonium salts of acrylic acid or methacrylic acid45~
99.999 mol% (c) Ethylene glycol di(meth)acrylate, diethylene glycol di(meth)acrylate, triethylene glycol di(meth)acrylate, trimethylolpropane tri(meth)acrylate, pentaerythritol tri(meth)acrylate, N,N At least one selected from the group consisting of '-methylenebis(meth)acrylamide, triallyl isocyanurate, and pentaerythritol di(meth)acrylate
A polymer ( A poultice medicinal base material characterized by containing 1). 2. The medicinal poultice base material according to claim 1, which contains the polymer (1) in a proportion of 0.5 to 20% by weight.