JPH0438725B2 - - Google Patents

Description

[Detailed description of the invention]

[Industrial Field of Application] This invention relates to a base material for a poultice for use in a poultice. [Prior art] Poultices that are applied to bruises, sprains, neuralgia, muscle pain, and other inflamed areas of the human body must be absorbed into the affected area to perform its functions in order to have anti-inflammatory and analgesic effects. In addition to the type and amount of the medicinal ingredient, factors such as the water content of the base material in which the medicinal ingredient is dispersed and its ability to retain water (time) have a large influence. For example, it is said that the more water there is in a poultice, the more the drug will penetrate into the skin, and when used as a hot compress, the higher the water content, the greater its heat capacity, so the effect of the compress will last for a long time. It has the advantage of being able to be maintained. Due to these circumstances, sodium polyacrylate/
Polyhydric alcohol/gelatin/sodium algyl acid/
A combination of zinc oxide/kaolin/water, a combination of cellulose derivative/sodium polyacrylate/gelatin/polyhydric alcohol water, or a combination of sodium polyacrylate and crosslinked polyacrylic acid as water-soluble polymers. Proposals have also been made regarding methods of use. On the other hand, JP-A-55-122714 discloses a copolymer of acrylic acid and sodium acrylate, or a mixture of a part of acrylic acid with alkali metal bases and amines, or alkali metal bases and ammonia. Disclosed is a method for producing a cloth agent based on an acrylic copolymer made of a copolymer of partially neutralized acrylic acid neutralized with sodium acrylate and sodium acrylate. Further, JP-A-51-26217 discloses a poultice base material comprising a cellulose derivative, sodium polyacrylate, gelatin, polyhydric alcohol, and water. [Problems to be Solved by the Invention] All conventional poultice base materials have advantages and disadvantages, and in particular, the base material made of an acrylic copolymer described in JP-A No. 55-122714 has problems with the skin. It has excellent non-adhesion, elasticity, heat resistance, etc.
It has shortcomings in long-term storage, resulting in a decrease in adhesive strength and the phenomenon of so-called "sag". In addition, the poultice base material disclosed in JP-A-51-26217 is also excellent in that it has flexibility as a base material, but ``sagging'' occurs under high humidity, causing problems in long-term storage. There is. In view of these conventional problems, the present invention has developed a poultice base material that does not contain an excessively wide variety of ingredients, has appropriate consistency and water retention, and has a pH value that does not irritate the skin. This was completed as a result of various studies regarding the base material. [Means for Solving the Problems] The poultice base material of the present invention is an acrylic material comprising 10% by weight or less of a cellulose derivative and the following general formula [] and/or general formula [] based on the total weight of the base material. A poultice base material comprising 0.5 to 10% by weight of an acid and/or methacrylic acid copolymer, 20% by weight or less of gelatin, 5 to 50% by weight of a polyhydric alcohol, and the balance being water. General formula [] General formula [] (In the formula, R=H or CH ₃ , M=Na, K,
_NH4 , _C1-2 aminoalkyl group, _R1 = _C1-4 alkyl group, m/ _{l +} m=0.1-0.7, m/l+m
+n=0.1 to 0.7, = about 1000 to 100000). In this invention, as the cellulose derivative constituting a part of the base material, methyl cellulose, carboxymethyl cellulose, partially modified products thereof, or other materials having equivalent functions can be selected and used, and the desired group can be used. One or more of the cellulose derivatives described above are mixed and used under compounding conditions appropriate to the flexibility of the material. The amount of cellulose derivative used is 10% by weight or less, preferably 2 to 8% by weight based on the total weight of the base material. The acrylic acid and/or methacrylic acid copolymer represented by the general formula [] or [] is selected from those with an average polymer () of approximately 1,000 to 100,000, preferably 10,000 to 80,000, More preferably, the number is 15,000 to 60,000. If the average degree of polymerization is smaller than the above lower limit, sufficient viscosity and, therefore, sufficient adhesion and hiding power to the skin cannot be obtained, and if it is too large, the clay becomes too high, which may cause problems such as hindering spreadability. state. The copolymerization ratio of this acrylic acid copolymer is such that the proportion of allyl acid and/or methacrylic acid in the copolymer is 10 to 70 mol%, preferably 15 to 60 mol%. If the acrylic acid and/or methacrylic acid component is less than 10 mol%, the adhesion of the base material to the skin will be weak, and when mixed with water to obtain a poultice medicinal base material, a high PHZ value will be exhibited, and the It is also unfavorable from the standpoint of safety and stability of the drug in the poultice. On the other hand, if the acrylic acid and/or methacrylic acid component is 70 mol % or more, the pH value becomes too low and safety for the skin is impaired, which is not preferable. Such acrylic acid and/or methacrylic acid copolymer is contained in an amount of 0.5 to 10% by weight based on the total weight of the base material.
Preferably it is used in an amount of 1 to 8% by weight. If this amount is less than 0.5% by weight, the thickening effect and water retention will not be sufficient, and if it exceeds 10% by weight, the viscosity will be too high and the spreadability to supports such as fabric will be poor. In addition, polyhydric alcohols include glycerin,
One or more selected from propylene glycol, polyethylene glycol, etc. are used,
The amount used is in the range of 5 to 50% by weight based on the total weight of the base material. Other ingredients include 20% by weight or less of gelatin, and the remainder is water. Further, if necessary, a compound selected from alkaline earth metals and polyvalent metal compounds such as aluminum, iron, and zinc may be used in combination. In order to produce a poultice using the base material of the present invention, a suspension containing a medicinal ingredient such as salicylic acid ester, menthol, and camphor, a pigment such as zinc white, titanium oxide, and kaolin, and an emulsifier are added to the base material. It can be obtained by adding a suspension, kneading the mixture until it becomes uniform, spreading it on a support such as cloth, and polymerizing a release film on the exposed surface of the kneaded product. [Function] The poultice base material of the present invention has the general formula []
and/or a base material containing a predetermined amount of an acrylic acid-based copolymer consisting of the general formula It maintains an appropriate moisture content, does not cause so-called "dal" even in summer, and is weakly acidic to the extent that it does not cause a rash even if it is applied to the skin, which is naturally weakly acidic, for a long time. On the other hand, when using a base material containing a polymer such as sodium polyacrylate in conventional formulations, this material exhibits weak alkalinity, so there is a high risk of decomposing the salicic acid ester, which is a medicinal ingredient. However, the poultice base material of the present invention is weakly acidic as described above, so that the medicinal ingredients can be fully expected to be effective without the need for pre-decomposition effects. The acrylic acid and/or methacrylic acid component in this copolymer is capable of properly exerting its inherent water-soluble fisting motion on the base material, and has an excellent thickening effect. It can exhibit water retention and affinity for the skin. In particular, as a copolymer component, In addition to exhibiting an excellent thickening effect, the part shown by kaolin,
It is also effective as a binder for pigments such as zinc white, and can exhibit the effects of significantly improving water retention and maintaining appropriate flexibility and adhesion. [Example] Hereinafter, the poultice base material of the present invention will be explained in more detail with reference to Examples and Comparative Examples. Examples 1 to 7 and Comparative Examples 1 to 3 Using the copolymers shown in Table 1, base materials for poultices were made according to the formulations shown in Table 2, and their water retention and adhesive strength were evaluated. We investigated the movement. The results are shown in Table 2. The water retention property was measured after being left in air at a temperature of 37°C and a humidity of 64% RH for 10 hours. In addition, as for the adhesive strength, the adhesive strength test was performed on the products after 6 months had elapsed after placing them in an aluminum bag lined with polyethylene film and sealing them at a temperature of 25°C and 65% RH.

【table】 The symbols in Table 1 are as follows. Aa Acrylic acid MAa methacrylic acid MeMa methyl acrylate P (NaAa) Sodium polyacrylate

[Table] In Table 2, *1 indicates carboxymethyl cellulose, *2 indicates that A = glycerin, B = propylene glycol, and *3 indicates that "sag" occurred. As is clear from the results in Table 2, the poultice base material of the present invention has high water retention properties, has almost no change in adhesive strength even with changes in temperature and humidity, and is also sufficient for long-term storage. It is recognized that it can withstand Example 8 For the base materials obtained by the formulations of Examples 1 to 7,
The following medicinal ingredients (1) to (3) were added and mixed uniformly, and then spread on a support and the exposed surface of the drug was covered with a release film to prepare a poultice.

〔Effect of the invention〕

The poultice base material of this invention has as compounding ingredients:
This poultice base is composed of a cellulose derivative, an acrylic acid and/or methacrylic acid copolymer having the general formula [] and/or the general formula [], gelatin, and predetermined amounts of polyhydric alcohol and water. The poultice obtained by dispersing medicinal ingredients in wood and spreading it on cloth has excellent water retention and adhesion to the skin, and its weakly acidic liquid properties make it easy to apply to the skin. It not only ensures safety by not causing rash or loss of medicinal properties, but also has the excellent effect of not causing a decrease in adhesive strength or loss of efficacy such as "sag" during long-term storage. be.

Claims (1)

[Claims] 1. 10% by weight or less of a cellulose derivative based on the total weight of the base material, and 0.5 to 0.5 to 0.5% of an acrylic acid and/or methacrylic acid copolymer having the following general formula [] and/or general formula [] 10% by weight of gelatin, 20% by weight or less of gelatin, 5 to 50% by weight of polyhydric alcohol, and the remainder water. General formula [] General formula [] (In the formula, R=H or CH ₃ , M=Na, K,
_NH4 , _C1-2 aminoalkyl group, _R1 = _C1-4 alkyl group, m/ _l +m=0.1-0.7, m/l+m+
n=0.1~0.7, = approx. 1000~100000)