JPS6353163B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a composition that improves the composition ratio of high-density lipoproteins in blood, and more specifically, to a composition containing a special egg containing iodine as an active ingredient. Over the past ten years, the consumption of eggs in the United States has been on a steady decline, and in recent years in Japan, the consumption has also been flat or on the decline. A two-step hypothesis has emerged that explains these causes: dietary cholesterol increases serum cholesterol, and an increase in serum cholesterol in the human body increases the risk of coronary heart disease. This seems to be due to the development of the idea of inviting people. On the other hand, as a counter-argument, there is a study report that shows that there is no significant difference in the average level of serum cholesterol when people are given one to three eggs a day for several months in addition to their normal diet. The nutritional value of eggs is clear, and as a means of preventing heart disease.
The government cites the lack of proof that restricting the intake of chicken eggs is appropriate, but the trend of declining egg consumption has not been stopped. However, recent studies by many researchers have shown that the issue of serum cholesterol should not be a question of the total content, but rather what type and how much of it is included. . That is, a high level of high-density lipoprotein protects against coronary atherosclerosis, and a high level of low-density lipoprotein is a sign of the development and progression of heart disease.
The majority of people now believe that this is the case, and the effects of exercise, alcohol, and various drugs are being discussed as influences on this. When the amount of high-density lipoprotein decreases, an increase in low-density lipoprotein is often observed at the same time, but in order to suppress the progression of arteriosclerosis, it is necessary to reduce low-density lipoprotein as well as high-density lipoprotein. It is desired to increase the value, that is, to improve the composition ratio of high-density lipoproteins in the blood. Various measures to increase the blood concentration of high-density lipoproteins have been studied in dietary therapy, and egg yolk has also been taken up as one of the research topics. It has been reported that while protein increases markedly, the increase in high-density lipoprotein is mild (Nihon University Medical Journal 38, 1295, '76). In addition, dietary therapy for hyperlipidemia includes optimizing energy, restricting carbohydrates appropriately, and improving the balance between polyunsaturated fatty acids and saturated fatty acids, which increase high-density lipoproteins. Are known. However, if the balance is disrupted and the amount of polyunsaturated fatty acids is increased, both low-density lipoprotein and high-density lipoprotein will decrease, and diet therapy cannot be carried out over a long period without strong will from the individual. However, there is a need for the development of something that can be easily and reasonably ingested in daily life in the same way as food, and that can reliably improve the above composition ratio. Under these circumstances, the present inventor is currently researching the effects of trace ingredients added to feed on egg components, as well as the effects of egg components on lipid metabolism and blood cholesterol. The present invention was completed by discovering that the present invention has the effect of improving the composition ratio of high-density lipoproteins in the blood. That is, the gist of the composition of the present invention is to transfer 550 μg or more of iodine per egg into eggs, to enable intake of 550 to 200 μg of iodine per day, and to improve the composition ratio of high-density proteins in the blood. be. In the investigation conducted by the present inventor, there have been no reports that iodine or foods or compositions containing high iodine have the effect of improving the composition ratio of high-density lipoproteins in the blood, and the present invention is a pioneering invention. It can be said that there is. Iodine, which is an active ingredient of the composition according to the present invention,
Eggs containing 550 μg or more are usually obtained as follows. Namely, iodine compounds such as calcium iodate, potassium iodate, sodium iodate, potash iodide, sodium iodide, copper iodide, thymol iodide, calcium iodobehemate, diiodosalicylic acid, calcium periodate, or kelp. By mixing more than a certain amount of iodine-rich seaweed or its processed products into the feed,
This is administered to birds to increase the iodine content in their eggs. In this case, it is preferable to use calcium iodate as the iodine compound in terms of the health of the birds and the transfer rate of iodine to eggs, and it is even more preferable to use seaweed such as kelp in combination. The amount of iodine administered to birds varies depending on the type of bird, e.g. chickens, quails, etc., but in the case of egg-laying hens, it is approximately 10 to 250 mg per bird per day, and in the case of feeding mainly on eggs, it is approximately 10 to 15 mg. Preferably, it is administered. It is usually administered by mixing with feed, but in that case 1
Assuming that one bird ingests approximately 100g of feed per day, 100 g of feed is consumed per day.
~2,500 ppm of iodine may be blended, and when the composition of the present invention is made from eggs as they are, 100 to 150 ppm of iodine may be blended. When an iodine compound or a substance containing a large amount of iodine is administered to birds in this manner, the desired eggs containing a large amount of iodine are produced approximately one week later. For example, in the case of laying hens,
When feed containing about 100 ppm of iodine is administered, eggs containing about 600 to 800 μg of iodine per egg are produced. Normally, the iodine requirement for laying hens is 0.30 per kg of feed.
~0.35 mg (NRC), and the actual amount of iodine in commercial feed is 0.3 to 2.0 mg/Kg, but the amount of iodine in ordinary eggs produced by chickens raised on this commercial feed is 1. Approximately 6μg per piece (American
(Egg Board), each one contains about 30μg at most. Compared to ordinary eggs, the eggs obtained as described above have a much higher content of iodine. Eggs obtained by transferring 550 μg or more of iodine per egg in this way can be used as they are as the composition of the present invention, or they can be dried,
It may be subjected to treatments such as concentration, powdering, and granulation, and may also be used in the form of tablets, powders, etc. by mixing with various excipients or binders. If these eggs are not used in their raw form as a composition and a processed egg product is used as a composition, the content of iodine administered to birds can be increased to increase the iodine content in the eggs. It is desirable to be able to ingest 2000 μg. The toxicity test results for this composition are roughly as follows. Acute toxicity test Animals used Wister female rats Body weight 100-110 g (n=10) Using egg powder with high iodine content, orally administer up to 50 mg of iodine per 1 kg of rat body weight using a geometric series of doses. and observed 7 days later. As a result, not a single animal died, and no weight loss was observed. As mentioned above, no acute toxicity was observed in this composition. Furthermore, the results of an animal test regarding the effect of this composition on improving the composition ratio of high-density lipoproteins in blood are as follows. Experimental Example 1 Twenty-eight 3-week-old SD male rats were preliminarily fed with a commercially available solid basal diet for the first 10 days in a cage with a locomotor device, and then fed with a powdered basal diet (manufactured by Nihon Nosan Kogyo Co., Ltd.). Change, feeding time is 8-9am, 9pm-
The animals were fed with two meals at 10pm. At 7 weeks of age, the animals were divided into 14 groups so that their body weight and locomotor activity were averaged, and the animals were divided into two groups: a test group and a control group. The test feed was prepared by adding 2% of egg powder with a high content of
% (control feed) was added to the feed, and the animals were kept for an additional 10 weeks. The component compositions of the iodine-rich egg powder and regular egg powder obtained in Example 2 are shown in Table 1, and the component compositions of the test feed and control feed prepared by adding each egg powder are shown in Table 2. It is as shown in the table.

【table】

[Table] The animals were kept in a breeding room at a temperature of 25±2°C and a humidity of 50 to 80%. After administering the test and control diets to rats in each group for 10 weeks,
The rats were sacrificed by decapitation at 3:00 p.m., 9:00 p.m., and 24:00, and the total cholesterol and high-density lipoprotein cholesterol levels in the blood were measured, and the composition ratio of high-density lipoproteins in the blood (HDL ratio) was calculated. Since no differences were observed between each slaughter time, the performance results are based on the third
They are summarized as shown in the table. As is clear from the results, the composition ratio of high-density lipoproteins in the blood was improved.

【table】

[Table] Experimental Example 2 Twenty-six 3-week-old SD male rats were kept in a cage without a locomotor device, and once a week, water temperature was 30°C and flow rate was approximately 40 m/min without exercise using the locomotor device. A rearing test was carried out in exactly the same manner as in Experiment 1, except that the rats were subjected to exercise until they were exhausted using a forced swimming exercise device set at min.
Total cholesterol and high-density lipoprotein cholesterol levels in the blood of 14 animals in the experimental group and 12 animals in the second control group were measured in the same manner as in Example 1. The results are shown in Table 4, and it is clear that the composition ratio of high-density lipoproteins in the blood is improved.

[Table] Furthermore, the clinical results regarding the effect of this composition on improving the composition ratio of high-density lipoproteins in blood are as follows. Clinical example: Ten patients with hypercholesterolemia were given egg powder containing high iodine, obtained in Example 2 below, for about 2 to 30 minutes.
3 g per day was administered for 3 months, and the total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein amount in the blood were measured before and after administration. The results are shown in Table 5, and it is clear that high-density lipoprotein cholesterol increased and low-density lipoprotein decreased.

[Table] From the above experimental examples and clinical examples, it is clear that the composition of the present invention has the effect of improving the composition ratio of high-density lipoproteins in blood. Although the mechanism of action of the present invention to improve the composition ratio of high-density lipoproteins in the blood is not clear, iodine that passes through the chicken's body and transfers to eggs combines with egg components and is directly transferred to lipoproteins or lipoprotein lipase. It is presumed that it acts indirectly or improves the composition ratio based on the specific gravity of lipoproteins. The composition of the present invention is nutritionally excellent, has no side effects, and has slow-acting rather than quick-acting effects, so it is desirable to take it continuously.
According to the findings of the present inventor, if the amount of iodine per egg is about 550 to 1000 μg and if you eat 1 to 2 eggs per day, the amount of iodine per day is 550 to 2000 μg. It is extremely easy to ingest iodine in daily life, and if eggs are processed into a composition such as powdered or granulated, a small amount of the composition with high iodine content is ingested and the amount of iodine is 550 to 2000 μg per day. Just do it like this. Approximately 1
The improvement effect will appear after about a few months. Furthermore, even if ingested over a long period of time, the composition of high-density lipoproteins in the blood will not become abnormal, so the composition of the present invention can be consumed without worrying about heart disease or the like. Example 1 Calcium iodate was added to a commercially available feed for adult chickens to give an iodine content of 100 ppm, and this feed was fed to chickens 3 months after they started laying eggs and raised. After 10 days, eggs containing an average of 550 μg of iodine were obtained. Example 2 Calcium iodate was added to commercially available adult chicken feed to give an iodine content of 2000 ppm, and 1% seaweed powder was added, and this feed was fed to 100 chickens 7 months after they started laying eggs. I bred them. The iodine content per egg obtained by the above breeding was 5300 μg. 170 kg of these eggs were dried using a spray dryer to obtain 35 kg of the composition of the present invention. The iodine content of this egg powder composition is 411mg/
It was Kg. Example 3 Calcium periodate was added to a commercially available feed for adult chickens so that the amount of iodine was 150 ppm, and eggs containing an average of 1250 μg/piece of iodine were obtained in the same manner as in Example 1. After breaking these eggs, 10% dextrin was added, water was added, and the mixture was thoroughly mixed and spray-dried using a spray dryer to obtain the composition of the present invention. Example 4 Diiodosalicylic acid was added to a commercially available feed for adult chickens so that the iodine content was 100 ppm, and 1% of kelp powder was added, and this feed was given to laying hens in the same manner as in Example 1. Eggs containing iodine were obtained.

Claims (1)

[Claims] 1. Eggs or egg-processed products that are made by administering a certain amount or more of iodine compounds and/or seaweed to birds so that 550 μg or more of iodine is transferred to each egg, allowing them to ingest 550 to 2000 μg of iodine per day. 1. A composition for improving the composition ratio of high-density proteins in the blood, characterized in that the composition contains the following: