JPS6364984B2 - - Google Patents

Description

[Detailed description of the invention]

"Industrial Application Field" The present invention relates to a method for producing seamless capsules having a plurality of cores, and is used in pharmaceuticals, chemicals, agricultural chemicals, fragrances, foods, adhesives, and other fields. ``Prior art'' As disclosed in Japanese Patent Application Laid-Open No. 88027/1988, the conventional method for manufacturing a multi-nuclear seamless capsule involves the production of a fluid outer coating material from the outer tube nozzle of a double tube nozzle. By simultaneously extruding fluid capsule filling materials from the inner tube nozzle into the coolant flow along the flow, a state where one capsule filling material flow exists in the outer coating material is created. A composite jet stream is formed, the composite jet stream is cut from the tip to form a plurality of depressions at predetermined intervals, and the composite jet stream is cooled and solidified while being formed into an elongated capsule in the cooling liquid flow to form the depressions. Some manufacture seamless capsules having separate cores of capsule filling material for each section. It is said that manufacturing by this method has the effect of elongating the capsule into a rugby ball shape and determining the direction of rolling. ``Problems to be solved by the invention'' When several substances that are to be used at the same time are allowed to coexist for a certain period of time, such as by mixing them prior to use, they may react with each other, harden and polymerize, or generate gas. Otherwise, the effectiveness of the drug decreases due to decomposition, so it is not possible to mix it in advance, and there are many products that are mixed in by adjusting the amount at the time of use. Examples of such substances in the pharmaceutical field include those shown in Table 1. Furthermore, in many adhesives, the monomer and curing agent cannot be mixed in advance, such as urethane monomers (polyols) and toluene disocyanate.

[Table] By the way, in the conventional manufacturing method described above, there is only one flow of capsule filling material in the composite jet stream, so it is not possible to confine capsule filling materials of different components into one capsule as in the example above. It has drawbacks. SUMMARY OF THE INVENTION An object of the present invention is to overcome the drawbacks of the conventional manufacturing methods and provide a method for manufacturing a seamless capsule with multiple nuclei, which can independently encapsulate a plurality of substances in the same capsule. ``Means for Solving the Problems'' A composite jet flow in which multiple flows of a fluid capsule filling material are contained independently in a state of being wrapped in a fluid envelope material is The substance is continuously formed in a liquid flow of an insoluble medium liquid along the liquid flow, and the composite jet stream is sequentially cut into predetermined lengths from the tip in the flow direction in the liquid flow. This is the point that was constructed. "Operation" Since the capsule filling material in the composite jet stream is formed into a plurality of independent flows, when the composite jet stream is cut into a predetermined length, a plurality of independent nuclei are formed in each cut droplet. If different types of substances are used for each flow of capsule filling material, the plurality of independent cores will each have different components. "Embodiment" FIGS. 1 and 2 show an example of an apparatus for carrying out the method of the present invention. 1 is a tank for outer coating material A, 2 is a tank for capsule filling material B, and 3 is a tank for another capsule filling material C. Each tank 1, 2, and 3 adjusts each material A, B, and C to an appropriate temperature. It is equipped with a heating means (not shown) for heating, and is configured so that each substance A, B, and C can be replenished into the respective tanks 1, 2, and 3 at any time. 4 is a composite nozzle facing downward into the medium liquid a made of cooled liquid paraffin in the capsule forming tank 5; Inner tube nozzle 4
The outer tube nozzle 40 communicates with the tank 1 via the feed pipe 11, and the inner tube nozzle 41 communicates with the tank 2 via the feed pipe 21.
The other inner tube nozzle 42 communicates with the tank 3 via the feed pipe 31. The medium liquid a is sent from the recovery hopper 6 which also serves as a tank to the heat exchanger 62 by a pump 61, cooled to 0 to 5°C by the heat exchanger 62, and supplied to the upper part of the capsule forming tank 5. The liquid flows downward within the capsule recovery tube 5 and circulates back to the recovery hopper 6 via the capsule recovery pipe 51. Further, a part of the medium liquid a is supplied from the hopper 6 to the intermittent flow forming device 64 by the pump 62, and the intermittent flow forming device 6
4, it is made into a regular intermittent flow and is supplied to an intermittent flow nozzle 7 provided in a capsule forming tank 5. The intermittent flow nozzle 7 is an annular nozzle provided to surround the lower part of the composite nozzle 4, and the intermittent flow of the medium liquid from the nozzle 7 flows from the side periphery toward the center of the nozzle 7. In this example, the outer coating material A is gelatin.
Using a mixed solution of 27% glycerin, 10% glycerin, and 73% purified water, maintain the temperature at about 60°C and adjust the viscosity to about 350 CPS. Capsule filling material B also contains 31% sodium bicarbonate, medium chain fatty acid triglyceride (for example, commercially available under the trade name "Panasate 810").
61%, sorbitan monooleate (e.g., commercially available under the trade name "Nitsukor S0-10")8
% solution, keep the temperature at about 25℃ and reduce the viscosity to about
Adjust to 300CPS. In addition, capsule filling material C contains 23% tartaric acid, 69% medium chain fatty acid triglyceride (e.g., commercially available under the trade name "Panasate 810"), and sorbitan monooleate (e.g., commercially available under the trade name "Nitsukol").
Using an 8% solution (commercially available as "S0-10"), maintain the temperature at about 25℃ and adjust the viscosity to about 250 CPS. The composite nozzle 4 transfers a composite jet stream b in which two flows of capsule filling materials B and C are independently present in the outer coating material A to the liquid medium a in the capsule forming tank 5. A metering pump 1 is a means for forming the liquid along the flow, and is provided in the feeding pipes 11, 21, 31.
2, 22, and 32, the outer membrane material A and the capsule filling materials B and C are pumped at a constant speed to the respective nozzles 40, 41, and 42 constituting the composite nozzle 4, and the aforementioned The composite jet stream b is continuously and quantitatively extruded along the descending liquid flow of the medium liquid a in the capsule forming tank 5. The intermittent flow from the intermittent flow nozzle 7 constitutes means for sequentially cutting the composite jet flow b into predetermined lengths from the tip of the descending liquid flow in the flow direction, and the composite jet flow b extruded from the composite nozzle 4 b is subjected to the impact of a regular intermittent flow of medium liquid from the intermittent flow nozzle 7, which causes the
As shown in the figure, depressions are sequentially formed at regular intervals from the tip of the composite jet flow b, and are pulled downward by the descending flow of the medium liquid a and are sequentially cut from the depressions, so that the surface of the outer coating substance A is Due to tension, the second
As shown on an enlarged scale in the figure, two cores composed of filler materials B and C become droplets d that are independently present in outer coating material A. Each droplet d formed as described above is formed into a seamless capsule c with a smooth surface while descending in the flow of the medium liquid a, as in the conventional general seamless capsule manufacturing method,
While being cooled and solidified, it reaches the hopper 6 through the recovery pipe 51, is separated from the medium liquid a by the separator 60 of the hopper 6, and is supplied to the side conveyor 8, where it is subjected to the next known blow drying process (not shown). Sent and dried. In the seamless capsule c according to the above embodiment, since the outer coating material A is a water-soluble polymer, it can absorb carbon dioxide gas and salts generated by the reaction of sodium bicarbonate in the filling material B and tartaric acid in the filling material C. It is used as a laxative. When sodium hydrogen carbonate and tartaric acid are mixed as described above, they undergo a chemical reaction and generate carbon dioxide gas, making them difficult to handle. However, when produced by the method of the present invention, both of them form independent nuclei within the capsule. Therefore, there is no reaction between the two in the capsule, and if both are quantitatively filled in the same capsule, there is no need to mix the two in respective amounts at the time of use. Composite nozzle 4 used in the above embodiments
As shown in the enlarged view in FIG.
1,42, the resulting seamless capsule c is a rugby ball-shaped capsule with an elliptical cross section and two cores made of filling materials B and C, as shown in FIG. It has directionality in rolling. In the method of the present invention, as shown in FIG. 3 and FIG. It can also be carried out using the nozzle 4. That is, in this case, each outer tube nozzle 4
Mutual outer coating material A continuously extruded from 0
are extruded and simultaneously fused to each other as shown in Figure 3, so the composite jet flow b formed consists of two independent flows of capsule filling materials B and C wrapped in outer membrane material A. This is because there is an inherent jet flow. The other steps are the same as those in the previous embodiment, so their explanation will be omitted. To seal the adhesive into the seamless capsule in a manner similar to the previous example, for example, the outer skin material A
Carnauba is used as the capsule filling material B, an epoxy resin adhesive is used as the capsule filling material B, tetraethylene pentamine which is a hardening agent for the resin is used as the capsule filling material C, and glycerin is used as the medium liquid a.
The manufacturing method in this case is similar to the above example, so a detailed explanation will be omitted. However, since the outer coating material A is carnauba that melts with heat, water and solvent can be removed from the outer coating material without the need for a drying step. Become. In addition, when using a water-insoluble polymer material, such as a methanol solution of polyvinyl acetate resin, as the outer coating material, the methanol in the polyvinyl acetate resin, which is the outer coating material, is removed in glycerin after encapsulation. The outer coating material is cured and then dried. Furthermore, to produce a seamless capsule with, for example, three independent cores, a composite nozzle 4 as illustrated in FIGS. 7 and 9 is used. The composite nozzle 4 shown in FIG. 7 has three small-diameter inner tube nozzles 41, 42, and 43 spaced apart from each other in an outer tube nozzle 40 having an elongated elliptical shape at its tip end. When used in the apparatus shown in Figure 1, capsule filling materials B, C, and D are used as shown in Figure 8.
A capsule c having an elongated elliptical cross section and having three independent cores consisting of FIG. 9 shows a large-diameter outer tube nozzle 40 with a similar triangular tip surface, and three small-diameter inner tube nozzles 41 spaced apart therein.
42 and 43 constitute a composite nozzle 4,
When this nozzle 4 is used, a seamless capsule c having a cross-sectional shape as shown in FIG. 10 is manufactured. In order to manufacture a seamless capsule having a larger number of nuclei, a composite nozzle 4 having a tip end face shaped as shown in FIGS. 11 and 13, for example, is used. The composite nozzle shown in FIG. 11 has small-diameter inner tube nozzles 41 to 47 spaced apart from each other in a large-diameter cylindrical outer tube nozzle 40. When this nozzle 4 is used, As shown in FIG. 12, a seamless capsule c having a substantially spherical shape and having many cores made of filling materials B to H is manufactured. Further, the composite nozzle 4 shown in FIG. 13 includes an outer tube nozzle 40 having a cylindrical shape with an elongated tip surface, and inner tube nozzles 41 to 41 having a small diameter spaced apart from each other.
45, and when this nozzle 4 is used, an elongated seamless capsule c having five cores made of filling materials B to F as shown in FIG.
is manufactured. The manufacturing method when using the composite nozzle 4 shown in FIGS. 7, 9, 11, and 13 is also substantially the same as that described in FIGS. 1 and 2, so detailed explanation will be omitted. In each of the above embodiments, the capsule filling materials can be implemented with the same ingredients or with different ingredients. Further, the outer coating material may have a double layer, and when the outer coating material has a double layer, the composite nozzle 4
The outer tube nozzle 40 may have a double structure. Furthermore, in order to cut the composite jet flow b into a predetermined length from the tip in the flow direction, instead of providing an intermittent flow as in the above embodiment, the descending liquid flow of the medium liquid a is intermittently accelerated, and the speed is increased. It can also be carried out by intermittently pulling downward with a liquid stream to sequentially cut into predetermined lengths. "Effects of the Invention" According to the method for manufacturing a multi-nucleate seamless capsule according to the present invention, the composite jet flow of the shell material and the capsule filling material formed in the medium liquid is generated by the capsule filling material wrapped in the shell material. Because multiple flows of matter are in a state of being internalized independently, capsules not only have multiple independent cores of the same component, but also multiple independent cores each of capsule filling materials of different components. Seamless capsules can be manufactured. Therefore, it is possible to fill the same capsule with multiple substances that cannot be or are not appropriate to be blended prior to use, and used without blending at the time of use. Convenient multi-nuclear seamless capsules can be manufactured.

[Brief explanation of drawings]

FIG. 1 is an overall system diagram illustrating an example of an apparatus for carrying out the manufacturing method according to the present invention, with a partial cross section; FIG. 2 is an enlarged sectional view of the main parts of the apparatus of FIG. 1; and FIG. 4 is an enlarged sectional view of the compound nozzle in FIG. 3; FIG. 5 is an enlarged end view of the compound nozzle in the device in FIG. 1; The figures are cross-sectional views of seamless capsules when using the composite nozzle in Figure 5, Figures 7, 9, 11, and 13.
The figure is an enlarged end view showing another example of a composite nozzle.
10, 12 and 14 are cross-sectional views of seamless capsules manufactured using the composite nozzles of FIGS. 7, 9, 11 and 13, respectively. Explanation of main symbols in the figure: a: medium liquid; b: composite jet flow; c: seamless capsule; A: outer coating material; B to H: capsule filling material; 4: composite nozzle; 40: outer tube nozzle; 47 is an inner pipe nozzle, 5 is a capsule forming tank, and 51 is a capsule recovery pipe.

Claims (1)

[Claims] 1. A composite jet flow in which multiple flows of fluid capsule filling material are contained independently in a state of being wrapped in a fluid outer coating material is mixed with a medium liquid that is not dissolved in the outer coating material. The composite jet stream is continuously formed along the liquid stream, and while each substance in the composite jet stream maintains its fluidity, the composite jet stream is sequentially formed in the liquid stream from the tip in the flow direction. A method for producing a multi-nuclear seamless capsule, the method comprising the step of cutting into a predetermined length.