JPH0225909B2 - - Google Patents
Info
- Publication number
- JPH0225909B2 JPH0225909B2 JP20080286A JP20080286A JPH0225909B2 JP H0225909 B2 JPH0225909 B2 JP H0225909B2 JP 20080286 A JP20080286 A JP 20080286A JP 20080286 A JP20080286 A JP 20080286A JP H0225909 B2 JPH0225909 B2 JP H0225909B2
- Authority
- JP
- Japan
- Prior art keywords
- present
- plants
- tannins
- novel
- effects
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 241000196324 Embryophyta Species 0.000 description 5
- 229920001864 tannin Polymers 0.000 description 5
- 239000001648 tannin Substances 0.000 description 5
- 235000018553 tannin Nutrition 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 235000002754 Acer pseudoplatanus Nutrition 0.000 description 1
- 240000004731 Acer pseudoplatanus Species 0.000 description 1
- 235000021513 Cinchona Nutrition 0.000 description 1
- 241000157855 Cinchona Species 0.000 description 1
- 241000723347 Cinnamomum Species 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 235000006485 Platanus occidentalis Nutrition 0.000 description 1
- 241000218220 Ulmaceae Species 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
本発明は医薬品として有用な新規タンニンに関
する。
タンニンは広く植物界に分布し、収斂作用のあ
ることが古くから知られ、収斂薬として、また皮
を革に変化させるなめし剤として多く用いられて
きた。
タンニンは分子量600〜2000ほどの植物の微量
成分で複雑な構造を有しており、単離精製の困難
さとあいまつて研究が遅れていた。
一方、従来より、地楡等の植物が、酵素阻害作
用等に基づく有用な医薬的効果を有することが知
られていた。
本発明者らは、これらの植物の薬効成分を検索
する目的で新規タンニンを単離取得して薬理効果
を調べた結果、幸運にも新規なるタンニンに酵素
阻害作用のあることを見出し本発明を完成した。
本発明に係る化合物は、体中酵素蛋白と結合す
ることによつてその活性を低下させる作用を有し
ている。
本発明に係る化合物は、地楡、キナ、釣藤鈎、
クスノキ、桂皮、シヤリンバイ等の植物から、ア
セトンによる抽出、酢酸エチル：水の分配、ある
いはカラムクロマト等の公知の方法により容易に
得ることができる。これらの方法を総括して示せ
ば、例えば次のようである。
The present invention relates to novel tannins useful as pharmaceuticals. Tannins are widely distributed in the plant kingdom, and have long been known to have astringent effects, and have been widely used as an astringent and as a tanning agent to transform hides into leather. Tannin is a trace component of plants with a molecular weight of about 600 to 2,000, and has a complex structure, which, combined with the difficulty of isolation and purification, has delayed research. On the other hand, it has been conventionally known that plants such as elms have useful medicinal effects based on enzyme inhibitory effects and the like. The present inventors isolated and obtained novel tannins for the purpose of searching for the medicinal components of these plants, and investigated their pharmacological effects. Fortunately, the present inventors discovered that the novel tannins had an enzyme-inhibiting effect and developed the present invention. completed. The compound according to the present invention has the effect of reducing the activity of enzyme proteins in the body by binding to them. The compound according to the present invention includes elm, cinchona, chutoga,
It can be easily obtained from plants such as camphor tree, cinnamon, and sycamore by known methods such as extraction with acetone, ethyl acetate:water partitioning, or column chromatography. These methods can be summarized as follows, for example.
【表】
アセトン溶出液
〓Sanguiin H〓5 〓
【table】
Acetone eluent
〓Sanguiin H〓5 〓
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20080286A JPS6242982A (en) | 1986-08-26 | 1986-08-26 | Novel tannin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20080286A JPS6242982A (en) | 1986-08-26 | 1986-08-26 | Novel tannin |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57036833A Division JPS58154571A (en) | 1982-03-08 | 1982-03-08 | Novel tannin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6242982A JPS6242982A (en) | 1987-02-24 |
| JPH0225909B2 true JPH0225909B2 (en) | 1990-06-06 |
Family
ID=16430433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP20080286A Granted JPS6242982A (en) | 1986-08-26 | 1986-08-26 | Novel tannin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6242982A (en) |
-
1986
- 1986-08-26 JP JP20080286A patent/JPS6242982A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6242982A (en) | 1987-02-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ITO et al. | A new method to synthesize α-aminoaldehydes | |
| US4108985A (en) | Dihydrocyclosporin c | |
| US4210581A (en) | Organic compounds | |
| JPH0229078B2 (en) | ||
| ES438946A2 (en) | Vincaminic acid esters | |
| Rao et al. | E-73: An antitumor substance. Part I. isolation and characterization1 | |
| Markkanen et al. | Antiherpetic Agent From Juniper Tree(Juniperus communis), its Purification, Identification, and Testing in Primary Human Amnion Cell Cultures. | |
| JPS62142181A (en) | Novel tannin | |
| JPS6248677A (en) | Novel tannin | |
| UENO et al. | Studies on the lupin alkaloids. VII. Isolation and structure of (-)-Δ7-dehydrosophoramine | |
| JPH0225909B2 (en) | ||
| IE39246L (en) | Preparing a purified extract of quillaia bark | |
| Kaslander et al. | On the transformation of the fungicide sodium dimethyldithiocarbamate into its alanine derivative by plant tissues | |
| JPS6353993B2 (en) | ||
| Boger et al. | Thermal, three-carbon+ two-atom cycloaddition of cyclopropenone ketals with carbon-heteroatom double bonds: Butenolide, furan, and γ-keto ester preparation. | |
| JPH0246598B2 (en) | SHINKINARUTANNIN | |
| JPS6249279B2 (en) | ||
| JPS61112089A (en) | Novel tannin | |
| US3002887A (en) | Method of purifying a dialyzable lipid mobilizer contained in blood | |
| JPS6249277B2 (en) | ||
| JPS6136826B2 (en) | ||
| ES8104992A1 (en) | 2-amino-1-(5-amino-1h-imidazol-4-yl)ethanone and method of preparation | |
| Gräsbeck et al. | Removal of R-type vitamin B12-binding protein from hog intrinsic factor preparations | |
| US3374252A (en) | Pharmaceutical product obtained from plants of the genus holarrhena (apocynaceae) | |
| Tomkeieff | Length of the Period of the Periodic System |