JPH0229078B2 - - Google Patents
Info
- Publication number
- JPH0229078B2 JPH0229078B2 JP57036833A JP3683382A JPH0229078B2 JP H0229078 B2 JPH0229078 B2 JP H0229078B2 JP 57036833 A JP57036833 A JP 57036833A JP 3683382 A JP3683382 A JP 3683382A JP H0229078 B2 JPH0229078 B2 JP H0229078B2
- Authority
- JP
- Japan
- Prior art keywords
- present
- plants
- tannins
- novel
- effects
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Landscapes
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Description
本発明は医薬品として有用な新規タンニンに関
する。
タンニンは広く植物界に分布し、収斂作用のあ
ることが古くから知られ、収斂薬として、また皮
を革に変化させるなめし剤として多く用いられて
きた。
タンニンは分子量600〜2000ほどの植物の微量
成分で複雑な構造を有しており、単離精製の困難
さとあいまつて研究が遅れていた。
一方、従来より、地楡等の植物が、酵素阻害作
用等に基づく有用な医薬的効果を有することが知
られていた。
本発明者らは、これらの植物の薬効成分を検索
する目的で新規タンニンを単離取得して薬理効果
を調べた結果、幸運にも新規なるタンニンに酵素
阻害作用のあることを見出し本発明を完成した。
本発明に係る化合物は、体中酵素蛋白と結合す
ることによつてその活性を低下させる作用を有し
ている。
本発明に係る化合物は、地楡，キナ，釣藤鈎，
クスノキ，桂皮，シヤリンバイ等の植物から、ア
セトンによる抽出，酢酸エチル：水の分配，ある
いはカラムクロマト等の公知の方法により容易に
得ることができる。これらの方法を総括して示せ
ば、例えば次のようである。
The present invention relates to novel tannins useful as pharmaceuticals. Tannins are widely distributed in the plant kingdom, and have long been known to have astringent effects, and have been widely used as an astringent and as a tanning agent to transform hides into leather. Tannin is a trace component of plants with a molecular weight of about 600 to 2,000, and has a complex structure, which, combined with the difficulty of isolation and purification, has delayed research. On the other hand, it has been conventionally known that plants such as elms have useful medicinal effects based on enzyme inhibitory effects and the like. The present inventors isolated and obtained novel tannins for the purpose of searching for the medicinal components of these plants, and investigated their pharmacological effects. Fortunately, the present inventors discovered that the novel tannins had an enzyme-inhibiting effect and developed the present invention. completed. The compound according to the present invention has the effect of reducing the activity of enzyme proteins in the body by binding to them. The compounds according to the present invention include elm, cinchona, chutoga,
It can be easily obtained from plants such as camphor tree, cinnamon, and sycamore by known methods such as extraction with acetone, ethyl acetate:water partitioning, or column chromatography. These methods can be summarized as follows, for example.
【表】
↓
アセトン溶出液
〓 Sanguiin H〓5 〓
[Table] ↓
Acetone eluent
〓 Sanguiin H〓5 〓
Claims (1)
【式】を表す。） で表される化合物。[Claims] First-order general formula [] (R 8 represents hydrogen or [formula].) A compound represented by:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57036833A JPS58154571A (en) | 1982-03-08 | 1982-03-08 | Novel tannin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57036833A JPS58154571A (en) | 1982-03-08 | 1982-03-08 | Novel tannin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP20080286A Division JPS6242982A (en) | 1986-08-26 | 1986-08-26 | Novel tannin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58154571A JPS58154571A (en) | 1983-09-14 |
| JPH0229078B2 true JPH0229078B2 (en) | 1990-06-27 |
Family
ID=12480741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57036833A Granted JPS58154571A (en) | 1982-03-08 | 1982-03-08 | Novel tannin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58154571A (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6116982A (en) * | 1984-07-03 | 1986-01-24 | Kikkoman Corp | Antioxidant |
| JPS61205272A (en) * | 1985-03-08 | 1986-09-11 | Tsumura Juntendo Inc | Novel tannin |
| JP2724597B2 (en) * | 1988-09-22 | 1998-03-09 | 日本精化株式会社 | Purification method of alkyl glycosides |
| WO1997036497A2 (en) * | 1996-04-02 | 1997-10-09 | Mars, Incorporated | Cocoa extract compounds and methods for making and using the same |
| KR100773647B1 (en) * | 1996-04-02 | 2008-11-07 | 마아스 인코포레이티드 | Cocoa extract compounds and methods for making and using the same |
| US6207842B1 (en) | 1997-10-09 | 2001-03-27 | Mars Incorporated | Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives |
| US6156912A (en) * | 1999-04-09 | 2000-12-05 | Mars, Incorporated | 88, 66, and 68 catechin and epicatechin dimers and methods for their preparation |
| US7015338B1 (en) | 1999-04-15 | 2006-03-21 | Mars Incorporated | Synthetic methods for preparing procyanidin oligomers |
| US7067679B2 (en) | 2002-10-02 | 2006-06-27 | Mars, Inc. | Synthesis of dimeric, trimeric, tetrameric pentameric, and higher oligomeric epicatechin-derived procyanidins having 4,8-interflavan linkages and their use to inhibit cancer cell growth through cell cycle arrest |
| SG10201505752QA (en) * | 2010-09-14 | 2015-09-29 | Chengdu Keer Pharmaceutical Co Ltd | Use of proanthocyanidin b2 for preparing medicaments |
| CN104510810B (en) * | 2013-10-08 | 2017-11-03 | 成都百草和济科技有限公司 | The new application of garden burnet or its extract |
| CN107827940B (en) * | 2017-11-20 | 2020-10-09 | 中国科学院昆明植物研究所 | Uncaria amide A and its pharmaceutical composition and application |
-
1982
- 1982-03-08 JP JP57036833A patent/JPS58154571A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS58154571A (en) | 1983-09-14 |
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