JPH0247228B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION (Industrial Field of Application) The present invention relates to an apparatus for dispensing a medical radiochemical solution from a container to a syringe.

(Prior Art) In recent years, radiological diagnosis, in which radioisotopes (RI) are administered into a patient's body and used as a tracer for diagnosis, has been actively carried out. In this case, since radioactivity is emitted from the chemical solution itself, there is an extremely high risk that the operator will be exposed to radiation during handling.

FIG. 5 shows a conventional method for dispensing this type of chemical solution. In Figure 5, 1 is a container (vial bottle) containing a radioactive drug solution (hereinafter referred to as RI), 2 is a shield made of lead etc. (vial shield) to prevent radioactivity from escaping, and 3
4 is a syringe for dispensing the required amount of RI, 4 is a shield made of lead etc. that is placed over the cylinder part of syringe 3 to prevent radioactivity from escaping, 5
is a lead glass that allows the scale of the syringe inside to be seen.

The operator holds the syringe 3 equipped with the shield 4 in his hand, sticks the needle into the stopper of the container 1, and inserts the piston 3.
After pulling a and dispensing the required amount of RI, the needle is removed and the patient is directly injected.

(Problems to be Solved by the Invention) However, in the conventional dispensing method described above, although the shields 2 and 4 are installed, they are not perfect, so radioactivity leaks, and furthermore, it is manual operation. However, it was unavoidable that the operator would be exposed to radiation during the dispensing process.

SUMMARY OF THE INVENTION An object of the present invention is to provide a radiopharmaceutical liquid dispensing device that automatically performs dispensing operations and minimizes radioactive exposure to the operator.

(Means for Solving the Problems) In order to achieve the above object, the radiopharmaceutical solution dispensing device of the present invention includes a container holder that holds a container containing a radiopharmaceutical solution in an inverted state, and a container holder for the container holder. a syringe holder disposed vertically movably below the syringe holder for holding a syringe with the needle facing upward; a first elevating mechanism for vertically moving the syringe holder; A piston end holding part that holds the piston end of the syringe, a second elevating mechanism that moves the piston end holding part up and down, and a first elevating mechanism based on a preset amount of drug solution dispensed. The syringe holder is raised, the syringe needle is inserted into the container stopper until the tip reaches the liquid in the container, and then the second elevating mechanism lowers the piston end holder to dispense the required amount of drug into the syringe. The system also includes a control section that controls a series of operations for dispensing the liquid, lowering the syringe holder using the first elevating mechanism, and removing the syringe needle from the stopper of the container.

(Function) According to the above configuration, the control section controls the first elevating mechanism and the second elevating mechanism according to the pre-installed program and based on the set drug solution dispensing amount, and the syringe holding section The necessary amount of RI can be automatically dispensed by raising the piston, lowering the piston end holder, and then lowering the syringe holder, minimizing the chance of radiation exposure for the operator. can be kept to a minimum.

(Example) Hereinafter, an example will be described in detail with reference to the drawings. First, FIG. 6 shows the appearance of a radiochemical liquid dispensing device according to an embodiment of the present invention. 51 is the main body of the dispensing device, 52 is the controller, and 53 is a cable connecting the two, including a power line and a signal line. 54 is a power cord. A container containing RI and a syringe for dispensing a desired amount of RI from the container are set in the dispensing device main body 51. The controller 52 includes an input section for setting a desired dispensing amount, a display section, a start button, etc., and also has a built-in CPU that controls all operations of the dispensing device.

1 to 4 show the internal structure of the dispensing device main body 51. As shown in FIG. First, in FIG. 1 showing the front and top surfaces of the device, 11 is a housing, 12 is a housing, and 12 is a housing.
14 is a syringe holder that holds the syringe 16 with the needle 15 facing upward; 17 is a button that covers the cylinder portion of the syringe 16; 18 is a lead glass provided so that the scale of the syringe can be seen; 19 is a piston end holder that holds the end of the piston 20 of the syringe. Shield 17 attached to the syringe
has an iron plate on the back, and the syringe holding part 14
A magnet is embedded in the part facing this, making it easy to attach and detach the syringe. 30 is a pulse motor.

Next, in FIG. 2 showing the back side of the device and the internal structure of the container holder 12, 21 is a rack fixed to the housing 11, and has a groove in the center as will be described later. 22 is a grooved rail fixed to the housing, 23 is a grooved rack fixed to the panel of the syringe holding part 14, and 24 is a grooved rail fixed to the panel of the syringe holding part 14. . 25a to 25d are rotatable wheels provided on the panel of the syringe holding part 14, and the grooves of the rack 21,
Or it is engaged with the groove of the rail 22. 26a-2
6d is a rotatable wheel provided on the panel of the piston end holding portion 19, and is engaged with a groove of the rack 23 or a groove of the rail 24. 27 and 28 are panel motors, and 29 is a limit switch.

The rack 21, the rail 22, the wheels 25a to 25d, and the panel motor 27 constitute a lifting mechanism (first lifting mechanism) for the syringe holder 14.
The main part is shown enlarged in FIG. That is, the rotatable 4 provided on the panel of the syringe holding part 14
The wheels 25a to 25d are engaged with the groove 31a of the rack 21 and the groove 31b of the rail 22, and are connected to a panel motor 27 fixed to the panel of the syringe holding part 14 via a built-in speed reducer. Since the pinion 32 meshes with the teeth of the rack 21, the rotation of the panel motor 27 causes the syringe holder 14 to move up and down. Similarly, Rack 23,
The rail 24, the wheels 26a to 26d, and the pulse motor 28 constitute an elevating mechanism (second elevating mechanism) for the piston end holding portion 19 relative to the holding portion 14. The elevating mechanism having the above-mentioned structure is characterized in that it moves smoothly and generates extremely little noise compared to a mechanism using a worm gear or the like.

Furthermore, in FIG. 2, 35 is a container holding plate;
6 is a moving plate, 37 is a needle position detection sensor section, 38,
39 is a pulse motor fixed to the top plate 40 of the casing for moving the moving plate 36.

The needle 15 attached to the syringe does not always align with the axis of the syringe, and the syringe attached by the magnetic chuck may be slightly misaligned. Therefore, if the needle tip is attached with the needle tip deviated from the axis, the syringe will be deviated from the mouth of the container 13 even if the syringe is raised as it is. Therefore, it is necessary to first detect the position of the needle tip and then move the container to match it. As the configuration of the needle position detection sensor section 37, for example, one in which a plurality of pairs of optical sensors (with a light emitting element and a light receiving element facing each other) are arranged side by side on two sets of mutually opposing sides of a square frame can be used. .

FIG. 4 shows a mechanism for moving the moving plate 36. The housing top plate 40 has arms 41a, 41
b and 41c are rotatably provided, and their rotation axes are driven by pulse motors 38 and 39, respectively, shown in FIG.
and is connected to a pulse motor 30 shown in FIG. The arms 41a, 41b, 41c are equipped with rotatable wheels 42a, 42b, 42c, respectively, and these wheels connect the long holes 4 formed in the moving plate 36.
3a, 43b, and 43c (see Figure 1).
The moving plate 36 includes rollers 44a arranged on the top plate 40,
44b, 44c, and is biased in the direction of arrow P by a spring or the like (not shown), and the initial position is set by limit switches 45a, 45b, 45c. When aligning the tip of the injection needle 15 with the opening of the container, the pulse motor 30 is driven to rotate the arm 41c to move the moving plate 36 by the necessary amount in the X direction, and then the pulse motors 38 and 39 are driven. The arms 41a and 41b are rotated to move the moving plate 36 by the required amount in the Y direction.

FIG. 7 shows the positioning control system, in which the needle position detection sensor section 37 includes a needle tip position detector in the vertical direction provided at the A level position, an X, It consists of a needle position detector in the Y direction, and these detection signals are sent to the controller 52.
The data is sent to the control unit 55 of. The control unit 55 controls the pulse motors 27 and 28 based on the detection signal,
The syringe holding part 14 and the piston end holding part 19 are driven. In addition, pulse motors 30, 38 and 3
9 to rotate the arms 41a, 41b, and 41c to match the position of the mouth of the container with the position of the needle.

Next, the operation of this embodiment will be explained with reference to the flowchart shown in FIG. First, as an initial setting, the container 13 containing RI is placed upside down on the holding plate 35, and the syringe 16 is placed on the syringe holding part 14.
Set to . Also, the dispensing capacity (e.g. 2.0ml)
is input at the input section of the controller 52. When the start button is pressed, the pulse motor 27 rotates and the first
The syringe holding part 14 is raised by the raising and lowering mechanism. When the needle tip reaches the upper chain line A shown in the needle position detection sensor section 37 in FIG. 2, the syringe holding section 14 temporarily stops. Therefore, the needle position in the X direction is first detected by the sensor disposed at the level of the lower chain line B shown in the needle position detection sensor section 37, and the pulse motor 30 operates according to the needle position, and the moving plate 36
The position is adjusted. Similarly, the needle position in the Y direction is detected, the pulse motors 38 and 39 are operated, and the position of the moving plate 36 is adjusted. After the needle position matches the position of the stopper of the container, the pulse motor 27 rotates again, the syringe holder 14 is raised a predetermined distance by the first elevating mechanism, and the needle is inserted into the stopper of the container. The needle tip reaches the RI in the container 13.

Next, the pulse motor 28 rotates, and the second elevating mechanism operates to lower the piston end holder 19, which holds the end of the piston of the syringe, by a distance corresponding to a preset dispensing volume to the desired level. Dispense the amount of RI into a syringe. In that state, pulse motor 2
7 rotates, the first elevating mechanism operates, the syringe holder 14 descends, and the needle is removed from the stopper of the container.
When the syringe holding part 14 returns to the initial position, the syringe is removed. Furthermore, the pulse motor 28 rotates, and the piston end holding part 19 returns to the initial position.
Dispensing work is completed.

The above operations are executed under the control of a pre-programmed controller.

It should be noted that if the needle position of the syringe set in the syringe holding part is provided with a mechanism that always maintains a constant position, there is no need to provide a needle position detection sensor part or a positioning mechanism part.

(Effects of the Invention) As explained above, according to the present invention, after the mouth of the drug solution container and the needle of the syringe are set facing each other, the first elevating mechanism operates according to the control of the control section. the syringe holder is raised a predetermined distance, the needle tip pierces the stopper of the container and reaches the drug solution, and then
The second elevating mechanism operates to lower the piston end holder by a distance necessary to inhale the preset dispensing device, and in this state, the first elevating mechanism operates to lower the syringe holder to a predetermined position. The operation of lowering the needle a distance and completely removing the needle tip from the stopper is performed automatically, and the necessary amount of radiochemical solution can be dispensed with high precision, minimizing radiation exposure to the operator and ensuring safety. It has the advantage of increasing sex.

[Brief explanation of the drawing]

FIG. 1 is a perspective view showing the internal front and top surfaces of the dispensing device main body according to an embodiment of the present invention, FIG. 2 is a view showing the back surface and the structure of the container holding part, and FIG. FIG. 4 is a perspective view showing the mechanism, FIG. 4 is a diagram showing the XY moving mechanism of the container holding part, FIG. 5 is a diagram showing the conventional dispensing method, and FIG. 6 is an example of the present invention. FIG. 7 is a block diagram of the alignment control system, and FIG. 8 is a flowchart of the dispensing operation. 12... Container holding part, 13... Container, 14...
Syringe holding part, 15... Needle, 16... Syringe, 1
9... Piston end holding part, 27, 28, 30, 3
8, 39... Pulse motor, 35... Container holding plate, 36... Moving plate, 37... Needle position detection sensor section, 51... Dispensing device main body, 52... Controller.

Claims (1)

[Claims] 1. A container holder 12 that holds a container 13 containing a radiochemical solution in an inverted state, and a syringe holder 14 that is arranged below the container holder so as to be movable up and down and holds a syringe 16 with a needle 15 facing upward. and a first elevating mechanism 2 that moves the syringe holder up and down.
1, 22, 25a to 25d, 27, a piston end holder 19 which is provided in the syringe holder so as to be movable up and down and holds the piston end of the syringe, and a second piston end holder which moves the piston end holder up and down. Based on the elevating mechanisms 23, 24, 26a to 26d, and 28, the first elevating mechanism raises the syringe holder 14 so that the tip of the syringe needle is inside the container. into the container stopper until reaching the liquid level, then the second elevating mechanism lowers the piston end holder 19 to dispense the required amount of drug into the syringe, and then the first elevating mechanism A radiopharmaceutical liquid dispensing device comprising: a control section that controls a series of operations of lowering the syringe holding section 14 and pulling out the syringe needle from the stopper of the container.