JPH0257900B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION Field of Industrial Application The present invention provides a method for producing 2-formyl-quinoxaline-1,4-dioxidecarbomethoxyhydrazone (carbadox), propylene, which has a body weight increasing effect and is 1 to 25% by weight. Concerning feed concentrates containing glycol and the usual ingredients of feed concentrates.

PRIOR ART AND PROBLEMS TO BE SOLVED BY THE INVENTION Most of the known preparation methods for carbadoxes are
Gives needle-like crystals of 1-200 μm length that are prone to breakage (eg Belgian Patent (BE-P) No. 669353 and US Pat. No. 3,493,572). When preparing feed concentrates, processing of carbadox can even lead to explosions due to the formation of carbadox dust. According to Belgian Patent No. 833441, this explosion hazard can be eliminated by formulating the ingredients of the feed concentrate in the presence of 2 to 8% by weight of non-toxic oil, preferably soybean oil, corn oil or mineral oil. You can avoid it. However, the oil added in this concentrate easily goes rancid, so the feed concentrate can only be stored for a relatively short period of time, otherwise the animal feed prepared from this feed concentrate will It becomes inedible for pigs. A further difficulty during formulation is that the oil used is not soluble and that it hardly wets the active substance, ie carbadox.

According to Belgian Patent No. 854,945, amorphous carbadox crystals with a length of 30 to 100 μm containing 15 to 40% by weight of water are used for the preparation of feed concentrates.
In all other respects, Belgian patent no.
The method of No. 833441 is followed. The explosion hazard associated with the processing of carbadox has been attempted to be eliminated by the use of a water content of 15 to 40% by weight, the use of non-toxic oils, and the use of intermediate crystal sizes. However, the water content of this active substance favors the growth of bacteria, and in the presence of bacteria the oil easily becomes rancid.

According to Hungarian Patent No. 178838, amorphous Carbadox crystals precipitated from an aqueous medium and having a length of 10 to 60 μm according to Hungarian Patent No. 171738 are added to feed concentrates in the presence of propylene glycol. Combine with the ingredients. According to this method, the spark sensitivity of Carbadox is significantly reduced. A disadvantage of the process is that a relatively small amount of liquid propylene glycol must be mixed into a large amount of solid material. However, with the available economical blenders equipped with spray nozzles it is not possible to obtain a homogeneous mixture, and in some cases the product is sticky and contains lumps. Additionally, the moisture content of feed concentrates can be increased due to the high hygroscopicity of propylene glycol, which also encourages bacterial growth.

Means for Solving the Problems Now, the drawbacks listed above are solved by the use of feed concentrates containing from 1 to 25% by weight of carbadox, as well as propylene glycol and the usual constituents of feed concentrates, said propylene glycol is bound to a solid support consisting of magnesium oxide, magnesium carbonate, magnesium peroxide and/or silica and contains 25 to 75% by weight of propylene glycol, calculated based on the total amount of support and propylene glycol. It has been found that this can be eliminated by the feed concentrate of the present invention.

The carrier containing propylene glycol contains 25 to 75% by weight of propylene glycol.
It is prepared by mixing, preferably by spraying, with 25% by weight of magnesium oxide and/or magnesium peroxide and/or magnesium carbonate and/or silica. Typically, the 80% solid support has a particle size of less than 10 μm. The solid carrier preferably has an average particle size of 1 to 5 μm.
The solid mixture thus obtained containing a large amount of propylene glycol can be handled like solid propylene glycol during mixing;
And it does not deliquesce even when stored for long periods of time, for example 30 days, in air at 75% relative humidity.

Preferred supports are magnesium carbonate, a mixture of magnesium carbonate and silica or a mixture of magnesium oxide and silica.

The feed concentrate of the present invention can be mixed into the usual ingredients of a carbadox feed concentrate in the presence of a solid carrier containing propylene glycol to obtain a carbadox content of 1 to 25% by weight. Mix and prepare. The amount of propylene glycol-containing carrier in the feed concentrate is usually 1 to 15% by weight, preferably 2 to 8% by weight.

It is preferred to mix carbadox as the last component into a mixture of the other ingredients of the concentrate, then add some carbadox, then some propylene glycol-containing solid support, then add more carbadox, etc.

Typical ingredients of feed concentrates are as follows: carriers such as alf-alf meal, wheat feed meal, bran, rice bran with reduced oil content;
Corn meal, soybean meal, wheat starch, corn starch, kaolin, calcium carbonate, etc.;
Additives, such as antioxidants, preservatives, trace elements, vitamins and salts, such as sodium chloride, magnesium chloride, magnesium sulfate, iron salts, etc.

The feed concentrate of the present invention can be diluted with the usual ingredients of animal feed to give a feed containing typically 0.001 to 0.0075% by weight of carbadox. The animal feed thus obtained is suitable for breeding pigs.

The feed concentrate of the present invention can be easily manufactured in a conventional blender. This feed concentrate is not hygroscopic, so it can be stored for long periods of time without any damage.

The presence of a propylene glycol-containing solid support completely eliminates the risk of explosion associated with the processing of carbadox. This explosion hazard can be characterized by the spark sensitivity, ie the minimum energy value that can produce a spark discharge leading to ignition. This value is therefore a measure of the flame and explosion hazard caused by electrostatic charging. The spark sensitivity of Carbadox was determined according to Hungarian Standard No. 16040.

The value of the sensitivity of the spark in the case of suspended carbadox powder is equal to 5 mJ. The spark sensitivity for feed concentrates containing Carbadox powder and liquid propylene glycol is 350 mJ.
The spark sensitivity for the feed concentrate of the invention is:
It is 500mJ. (The higher this value, the lower the risk of explosion.) From the above values, the spark sensitivity of Carbadox is greater in the presence of "solid" propylene glycol than in the presence of regular liquid propylene glycol. It can be seen that it has a much higher value.

EXAMPLES The invention is further illustrated by the following examples.

Binding of propylene glycol to a solid support 40 parts by weight of magnesium carbonate (average particle size: 1-
2 μm, 80% of particles have a particle size of 0.5-5 μm)
Lo¨dige with spray nozzle
Transferred to a vortex blender. Start mixing;
50 parts by weight of propylene glycol was sprayed at a constant rate. After spraying had ended, mixing was continued for an additional hour, then 10 parts by weight of finely divided silica were added and the mixture was homogenized for a further 10 minutes. The resulting mixture contained 50% by weight propylene glycol, 40% by weight magnesium carbonate and 10% by weight silica.

The following powder mixtures were prepared in a similar manner: 60% by weight propylene glycol + 40% by weight magnesium oxide; 70% by weight propylene glycol + 30% by weight magnesium carbonate; 52% by weight propylene glycol + 48% by weight peroxide. Magnesium 75% by weight propylene glycol + 25% by weight silica; 50% by weight propylene glycol + 50% by weight magnesium carbonate; 25% by weight propylene glycol + 60% by weight magnesium carbonate + 15% by weight silica.

Example 1 In a 1 m ³ capacity blender, 420 Kg of alf-alf amil, 182 Kg of wheat starch, 28 Kg of a powder mixture containing 50% by weight of propylene glycol, 40% by weight of magnesium carbonate and 10% by weight of silica,
Then 70 kg of Carbadox was added under stirring. Homogenization was continued for an additional 8 minutes.

700Kg of feed concentrate was obtained, which contained 10% by weight of Carbadox.

Example 2 480Kg of extracted sunflower meal, 480Kg of corn flakes, 30Kg of a powder mixture containing 60% by weight of propylene glycol and 40% by weight of magnesium oxide, followed by 10Kg of carbomics and homogenized.

1000 Kg of feed concentrate was obtained, which contained 1% by weight of carbadox.

Example 3 300Kg of dried sugar beet slice meal, 100Kg of trefoil meal, 40Kg of a powder mixture containing 50% by weight propylene glycol and 50% by weight magnesium carbonate, followed by 60Kg of Carbadox.
Kg was homogenized as described in Example 1.

500Kg of feed concentrate was obtained, containing 12% by weight of Carbadox.

Example 4 In the blender used in Example 1, 280Kg of barley meal, 140Kg of potato starch, 70% by weight
50 Kg of a powder mixture containing propylene glycol and 30% by weight of magnesium carbonate and then 80 Kg of Carbadox were added under mixing. These ingredients were homogenized for a further 10 minutes and then a further 55 Kg of a powder mixture containing 70% by weight propylene glycol and 30% by weight magnesium carbonate and 95 Kg Carbadox were added.

Homogenization was continued for an additional 12 minutes.

700Kg of feed concentrate was obtained, containing 25% by weight of Carbadox.

Example 5 350 Kg oatmeal, 250 Kg corn starch with reduced oil content, 30 Kg powder mixture containing 52% by weight propylene glycol and 48% by weight magnesium peroxide, and 70 Kg Carbadox.
was homogenized as described in Example 1.

700Kg of feed concentrate was obtained, which contained 10% by weight of Carbadox.

Example 6 10Kg of the concentrate from Example 1 was mixed with the following ingredients: 19.9Kg of corn meal, 5Kg of wheat meal, and 5Kg of barley meal.
18Kg of oatmeal, 5Kg of oatmeal, 2Kg of rice bran, 16Kg of extracted soybeans, 4Kg of fish meal, 20Kg of milk powder, 6Kg of fat powder, and 4Kg of a mixture containing inorganic substances, vitamins and trace elements. Obtained 100Kg of animal feed,
It contained 0.001% by weight carbadox.

Example 7 75g of the concentrate from Example 2 was combined with the following ingredients: 37.825Kg of corn meal, 6Kg of wheat meal, 25Kg of barley meal, 5Kg of oatmeal, 2.4Kg of bran, 13Kg of extracted soybeans, 6Kg of fish meal, 1.5Kg of fat powder, 1Kg of feed lime. , mixed into 0.5Kg of feed salt, and 1.7Kg of a mixture containing mineral substances, vitamins and trace elements. Obtained 100Kg of animal feed, which is 0.0075% by weight
It contained carbadox.

Claims (1)

[Claims] 1. Having a body weight increasing effect, and 1 to 25% by weight 2.
- formyl-quinoxaline-1,4-dioxidecarbomethoxyhydrazone (Carbadox),
A feed concentrate containing propylene glycol and the usual ingredients of feed concentrates, wherein said propylene glycol is bound to a solid carrier consisting of magnesium oxide, magnesium carbonate, magnesium peroxide and/or silica, and the carrier and feed concentrates containing 25 to 75% by weight propylene glycol calculated on the total amount of propylene glycol. 2. The feed concentrate of claim 1, wherein the propylene glycol is bound to magnesium carbonate. 3. Feed concentrate according to claim 1, wherein the propylene glycol is bound to magnesium carbonate and silica or magnesium oxide and silica.